Gregory Stephanopoulos - Related publications

Chemical Engineering Department Massachusetts Institute of Technology, Cambridge, MA, United States 
metabolic and biochemical engineering, biotechnology, bioinformatics
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50 most relevant papers in past 60 days:
Year Citation  Score
2019 Biz A, Proulx S, Xu Z, Siddartha K, Indrayanti AM, Mahadevan R. Systems biology based metabolic engineering for non-natural chemicals. Biotechnology Advances. PMID 30953683 DOI: 10.1016/j.biotechadv.2019.04.001   
2019 Kukurugya MA, Mendonca CM, Solhtalab M, Wilkes RA, Thannhauser TW, Aristilde L. Multi-omics analysis unravels a segregated metabolic flux network that tunes co-utilization of sugar and aromatic carbons in . The Journal of Biological Chemistry. PMID 30936206 DOI: 10.1074/jbc.RA119.007885   
2019 Bergman A, Vitay D, Hellgren J, Chen Y, Nielsen J, Siewers V. Effects of overexpression of STB5 in Saccharomyces cerevisiae on fatty acid biosynthesis, physiology and transcriptome. Fems Yeast Research. PMID 30924859 DOI: 10.1093/femsyr/foz027   
2019 Martien JI, Hebert AS, Stevenson DM, Regner MR, Khana DB, Coon JJ, Amador-Noguez D. Systems-Level Analysis of Oxygen Exposure in : Implications for Isoprenoid Production. Msystems. 4. PMID 30801024 DOI: 10.1128/mSystems.00284-18   
2019 Dudley QM, Nash CJ, Jewett MC. Cell-free biosynthesis of limonene using enzyme-enriched lysates. Synthetic Biology (Oxford, England). 4: ysz003. PMID 30873438 DOI: 10.1093/synbio/ysz003   
2019 Saavedra E, Encalada R, Vázquez C, Olivos-García A, Michels PAM, Moreno-Sánchez R. Control and regulation of the pyrophosphate-dependent glucose metabolism in Entamoeba histolytica. Molecular and Biochemical Parasitology. PMID 30772421 DOI: 10.1016/j.molbiopara.2019.02.002   
2019 Liu X, Niu H, Li Q, Gu P. Metabolic engineering for the production of l-phenylalanine in . 3 Biotech. 9: 85. PMID 30800596 DOI: 10.1007/s13205-019-1619-6   
2019 Amin SA, Gopinarayanan VE, Nair NU, Hassoun S. Establishing Synthesis Pathway-Host Compatibility via Enzyme Solubility. Biotechnology and Bioengineering. PMID 30802311 DOI: 10.1002/bit.26959   
2019 de Paula RG, Antoniêto ACC, Ribeiro LFC, Srivastava N, O'Donovan A, Mishra PK, Gupta VK, Silva RN. Engineered microbial host selection for value-added bioproducts from lignocellulose. Biotechnology Advances. PMID 30771467 DOI: 10.1016/j.biotechadv.2019.02.003   
2019 Jha RK, Narayanan N, Pandey N, Bingen J, Kern TL, Johnson CW, Strauss CEM, Beckham GT, Hennelly SP, Dale T. Sensor-enabled alleviation of product inhibition in chorismate pyruvate-lyase. Acs Synthetic Biology. PMID 30861344 DOI: 10.1021/acssynbio.8b00465   
2019 Zuo R, Ding Y. Direct Aromatic Nitration System for Synthesis of Nitrotryptophans in Escherichia coli. Acs Synthetic Biology. PMID 30865826 DOI: 10.1021/acssynbio.8b00534   
2019 Seo EJ, Kang CW, Woo JM, Jang S, Yeon YJ, Jung GY, Park JB. Multi-level engineering of Baeyer-Villiger monooxygenase-based Escherichia coli biocatalysts for the production of C9 chemicals from oleic acid. Metabolic Engineering. PMID 30953778 DOI: 10.1016/j.ymben.2019.03.012   
2019 Rantasalo A, Vitikainen M, Paasikallio T, Jäntti J, Landowski CP, Mojzita D. Novel genetic tools that enable highly pure protein production in Trichoderma reesei. Scientific Reports. 9: 5032. PMID 30902998 DOI: 10.1038/s41598-019-41573-8   
2019 Snider JM, Luberto C, Hannun YA. Approaches for probing and evaluating mammalian sphingolipid metabolism. Analytical Biochemistry. PMID 30917945 DOI: 10.1016/j.ab.2019.03.014   
2019 Da Y, Li W, Shi L, Li Z. [Microbial production of poly (glycolate-co-lactate-co-3-hydroxybutyrate) from glucose and xylose by Escherichia coli]. Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology. 35: 254-262. PMID 30806055 DOI: 10.13345/j.cjb.180199   
2019 Xu JM, Li JQ, Zhang B, Liu ZQ, Zheng YG. Fermentative production of the unnatural amino acid L-2-aminobutyric acid based on metabolic engineering. Microbial Cell Factories. 18: 43. PMID 30819198 DOI: 10.1186/s12934-019-1095-z   
2019 Luo Y, Zhao Q, Liu Q, Feng Y. An artificial biosynthetic pathway for 2-amino-1,3-propanediol production using metabolically engineered Escherichia coli. Acs Synthetic Biology. PMID 30781944 DOI: 10.1021/acssynbio.8b00466   
2019 Jeffryes J, Strutz J, Henry C, Tyo KEJ. Metabolic In Silico Network Expansions to Predict and Exploit Enzyme Promiscuity. Methods in Molecular Biology (Clifton, N.J.). 1927: 11-21. PMID 30788782 DOI: 10.1007/978-1-4939-9142-6_2   
2019 Xu H, Zhang Z, Li H, Yan Y, Shi J, Xu Z. Comparative proteomic analysis revealed the metabolic mechanism of excessive exopolysaccharide synthesis by Bacillus mucilaginosus under CaCO addition. Preparative Biochemistry & Biotechnology. 1-9. PMID 30861358 DOI: 10.1080/10826068.2018.1541806   
2019 Shumar SA, Kerr EW, Fagone P, Infante AM, Leonardi R. Overexpression of Nudt7 decreases bile acid levels and peroxisomal fatty acid oxidation in the liver. Journal of Lipid Research. PMID 30846528 DOI: 10.1194/jlr.M092676   
2019 Bouillaut L, Dubois T, Francis MB, Daou N, Monot M, Sorg JA, Sonenshein AL, Dupuy B. Role of the Global Regulator Rex in Control of NAD -Regeneration in Clostridioides (Clostridium) difficile. Molecular Microbiology. PMID 30882947 DOI: 10.1111/mmi.14245   
2019 Liu J, Sun Z, Mao X, Gerken H, Wang X, Yang W. Multi-omics analysis reveals distinct mechanism of oleaginousness in the emerging model alga Chromochloris zofingiensis. The Plant Journal : For Cell and Molecular Biology. PMID 30828893 DOI: 10.1111/tpj.14302   
2019 Zhong W, Zhang Y, Wu W, Liu D, Chen Z. Metabolic engineering of a homoserine-derived non-natural pathway for the de novo production of 1,3-propanediol from glucose. Acs Synthetic Biology. PMID 30802034 DOI: 10.1021/acssynbio.9b00003   
2019 Muchowska KB, Chevallot-Beroux E, Moran J. Recreating ancient metabolic pathways before enzymes. Bioorganic & Medicinal Chemistry. PMID 30871860 DOI: 10.1016/j.bmc.2019.03.012   
2019 Schilling B, Basisty N, Christensen DG, Sorensen D, Orr JS, Wolfe AJ, Rao CV. Global lysine acetylation in results from growth conditions that favor acetate fermentation. Journal of Bacteriology. PMID 30782634 DOI: 10.1128/JB.00768-18   
2019 Scott PM, Erickson KM, Troutman JM. Identification of the functional roles of six key proteins in the biosynthesis of Enterobacteriaceae colanic acid. Biochemistry. PMID 30821147 DOI: 10.1021/acs.biochem.9b00040   
2019 D'Arcy BM, Swingle MR, Schambeau L, Pannell L, Prakash A, Honkanen RE. Development of a Synthetic 3-ketosteroid Δ-dehydrogenase for the Generation of a Novel Catabolic Pathway Enabling Cholesterol Degradation in Human Cells. Scientific Reports. 9: 5969. PMID 30979909 DOI: 10.1038/s41598-019-42046-8   
2019 Liu C, Knudsen GM, Pedley AM, He J, Johnson JL, Yaron TM, Cantley LC, Benkovic SJ. Mapping post-translational modifications of de novo purine biosynthetic enzymes: Implications for pathway regulation. Journal of Proteome Research. PMID 30964683 DOI: 10.1021/acs.jproteome.8b00969   
2019 Xu JZ, Ruan HZ, Liu LM, Wang LP, Zhang WG. Overexpression of thermostable meso-diaminopimelate dehydrogenase to redirect diaminopimelate pathway for increasing L-lysine production in Escherichia coli. Scientific Reports. 9: 2423. PMID 30787467 DOI: 10.1038/s41598-018-37974-w   
2019 Luo X, Reiter MA, d'Espaux L, Wong J, Denby CM, Lechner A, Zhang Y, Grzybowski AT, Harth S, Lin W, Lee H, Yu C, Shin J, Deng K, Benites VT, et al. Complete biosynthesis of cannabinoids and their unnatural analogues in yeast. Nature. PMID 30814733 DOI: 10.1038/s41586-019-0978-9   
2019 Grocholski T, Yamada K, Sinkkonen J, Tirkkonen H, Niemi J, Metsä-Ketelä M. Evolutionary Trajectories for the Functional Diversification of Anthracycline Methyltransferases. Acs Chemical Biology. PMID 30995392 DOI: 10.1021/acschembio.9b00238   
2019 Guzmán GI, Sandberg TE, LaCroix RA, Nyerges Á, Papp H, de Raad M, King ZA, Hefner Y, Northen TR, Notebaart RA, Pál C, Palsson BO, Papp B, Feist AM. Enzyme promiscuity shapes adaptation to novel growth substrates. Molecular Systems Biology. 15: e8462. PMID 30962359 DOI: 10.15252/msb.20188462   
2019 Milanes JE, Suryadi J, Abendroth J, Van Voorhis WC, Barrett KF, Dranow DM, Phan IQ, Patrick SL, Rozema SD, Khalifa MM, Golden JE, Morris JC. Enzymatic and structural characterization of the glucokinase. Antimicrobial Agents and Chemotherapy. PMID 30783001 DOI: 10.1128/AAC.02410-18   
2019 Abdallah II, Pramastya H, van Merkerk R, Sukrasno, Quax WJ. Metabolic Engineering of Toward Taxadiene Biosynthesis as the First Committed Step for Taxol Production. Frontiers in Microbiology. 10: 218. PMID 30842758 DOI: 10.3389/fmicb.2019.00218   
2019 Xie SS, Qiu XY, Zhu LY, Zhu CS, Liu CY, Wu XM, Zhu L, Zhang DY. Assembly of TALE-based DNA scaffold for the enhancement of exogenous multi-enzymatic pathway. Journal of Biotechnology. PMID 30885657 DOI: 10.1016/j.jbiotec.2019.03.008   
2019 Lim SD, Lee S, Choi WG, Yim WC, Cushman JC. Laying the Foundation for Crassulacean Acid Metabolism (CAM) Biodesign: Expression of the C Metabolism Cycle Genes of CAM in . Frontiers in Plant Science. 10: 101. PMID 30804970 DOI: 10.3389/fpls.2019.00101   
2019 Yu X, Niks D, Ge X, Liu H, Hille R, Mulchandani A. Synthesis of Formate from CO Gas Catalyzed by an O-tolerant NAD-Dependent Formate Dehydrogenase and Glucose Dehydrogenase. Biochemistry. PMID 30839197 DOI: 10.1021/acs.biochem.8b01301   
2019 Lu X, Liu Y, Yang Y, Wang S, Wang Q, Wang X, Yan Z, Cheng J, Liu C, Yang X, Luo H, Yang S, Gou J, Ye L, Lu L, et al. Constructing a synthetic pathway for acetyl-coenzyme A from one-carbon through enzyme design. Nature Communications. 10: 1378. PMID 30914637 DOI: 10.1038/s41467-019-09095-z   
2019 Jabłońska J, Tawfik DS. The number and type of oxygen-utilizing enzymes indicates aerobic vs. anaerobic phenotype. Free Radical Biology & Medicine. PMID 30935870 DOI: 10.1016/j.freeradbiomed.2019.03.031   
2019 Su H, Guo Z, Wu X, Xu P, Li N, Zong M, Lou W. Efficient bioconversion of sucrose to high-value-added glucaric acid by in vitro metabolic engineering. Chemsuschem. PMID 30791217 DOI: 10.1002/cssc.201900185   
2019 Zang Y, Zha J, Wu X, Zheng Z, Ouyang J, Koffas MAG. In vitro Naringenin Biosynthesis from p-Coumaric Acid Using Recombinant Enzymes. Journal of Agricultural and Food Chemistry. PMID 30919618 DOI: 10.1021/acs.jafc.9b00413   
2019 Zhang Y, Ma C, Dischert W, Soucaille P, Zeng AP. Engineering of phosphoserine aminotransferase increases the conversion of L-homoserine to 4-hydroxy-2-ketobutyrate in a glycerol-independent pathway of 1,3-propanediol production from glucose. Biotechnology Journal. e1900003. PMID 30925016 DOI: 10.1002/biot.201900003   
2019 Muso Cachumba JJ, Terán Hilares R, Brumano LP, Marcelino PRF, Antunes FAF, Santos JC, da Silva SS. Extracellular L-asparaginase production in solid-state fermentation by using sugarcane bagasse as support material. Preparative Biochemistry & Biotechnology. 1-6. PMID 30712449 DOI: 10.1080/10826068.2019.1566152   
2019 Srivastava I, Sar D, Mukherjee P, Schwartz-Duval AS, Huang Z, Jaramillo C, Civantos A, Tripathi I, Allain JP, Bhargava R, Pan D. Enzyme-catalysed biodegradation of carbon dots follows sequential oxidation in a time dependent manner. Nanoscale. PMID 30973556 DOI: 10.1039/c9nr00194h   
2019 Erkal NA, Eser MG, Özgür E, Gündüz U, Eroglu I, Yücel M. Transcriptome analysis of Rhodobacter capsulatus grown on different nitrogen sources. Archives of Microbiology. PMID 30796473 DOI: 10.1007/s00203-019-01635-x   
2019 Zhao KJ, Chen Y, Hong SJ, Yang YT, Xu J, Yang HY, Zhu L, Liu M, Xie QS, Tang XG, Yang TT, Zhou YQ, Liu L, Liu XD. Characteristics of β-oxidative and reductive metabolism on the acyl side chain of cinnamic acid and its analogues in rats. Acta Pharmacologica Sinica. PMID 30792487 DOI: 10.1038/s41401-019-0218-8   
2019 Li Y, Wang M, Liu Z, Zhang K, Cui F, Sun W. Towards understanding the biosynthetic pathway for ustilaginoidin mycotoxins in Ustilaginoidea virens. Environmental Microbiology. PMID 30807673 DOI: 10.1111/1462-2920.14572   
2019 Haque RU, Paradisi F, Allers T. Haloferax volcanii as immobilised whole cell biocatalyst: new applications for halophilic systems. Applied Microbiology and Biotechnology. PMID 30877354 DOI: 10.1007/s00253-019-09725-y   
2019 Guo H, Han J, Wu J, Chen H. Heteroexpression and functional characterization of glucose 6-phosphate dehydrogenase from industrial . Journal of Microbiology and Biotechnology. PMID 30786701 DOI: 10.4014/jmb.1812.12064   
2019 Gissibl A, Care A, Sun A, Hobba G, Nevalainen H, Sunna A. Development of screening strategies for the identification of paramylon-degrading enzymes. Journal of Industrial Microbiology & Biotechnology. PMID 30806871 DOI: 10.1007/s10295-019-02157-7