Richard Novick, M.D. - Publications

Microbiology New York University, New York, NY, United States 
Staphylococcus aureus; superantigens; mobile genes; pathogenicity islands, signal transduction, regulation of virulence, microbial pathogenesis; MRSA; bacterial genetics

72 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Haag AF, Podkowik M, Ibarra-Chávez R, Gallego Del Sol F, Ram G, Chen J, Marina A, Novick RP, Penadés JR. A regulatory cascade controls Staphylococcus aureus pathogenicity island activation. Nature Microbiology. PMID 34518655 DOI: 10.1038/s41564-021-00956-2  0.309
2020 Xie Q, Wiedmann MM, Zhao A, Pagan IR, Novick RP, Suga H, Muir TW. Discovery of quorum quenchers targeting the membrane-embedded sensor domain of the Staphylococcus aureus receptor histidine kinase, AgrC. Chemical Communications (Cambridge, England). PMID 32820778 DOI: 10.1039/D0Cc04873A  0.481
2019 Novick R. Targeted killing of virulent Vibrio cholerae. Nature Biomedical Engineering. PMID 31209355 DOI: 10.1038/S41551-019-0419-Y  0.375
2019 Xie Q, Zhao A, Jeffrey PD, Kim MK, Bassler BL, Stone HA, Novick RP, Muir TW. Identification of a Molecular Latch that Regulates Staphylococcal Virulence. Cell Chemical Biology. PMID 30773482 DOI: 10.1016/J.Chembiol.2019.01.006  0.574
2017 Wang B, Zhao A, Xie Q, Olinares PD, Chait BT, Novick RP, Muir TW. Functional Plasticity of the AgrC Receptor Histidine Kinase Required for Staphylococcal Virulence. Cell Chemical Biology. 24: 76-86. PMID 28065658 DOI: 10.1016/J.Chembiol.2016.12.008  0.571
2015 Wang B, Zhao A, Novick RP, Muir TW. Key driving forces in the biosynthesis of autoinducing peptides required for staphylococcal virulence. Proceedings of the National Academy of Sciences of the United States of America. 112: 10679-84. PMID 26261307 DOI: 10.1073/Pnas.1506030112  0.518
2015 Johnson JG, Wang B, Debelouchina GT, Novick RP, Muir TW. Increasing AIP Macrocycle Size Reveals Key Features of agr Activation in Staphylococcus aureus. Chembiochem : a European Journal of Chemical Biology. 16: 1093-100. PMID 25801678 DOI: 10.1002/Cbic.201500006  0.577
2015 Wang B, Zhao A, Novick RP, Muir TW. Key driving forces in the biosynthesis of autoinducing peptides required for staphylococcal virulence Proceedings of the National Academy of Sciences of the United States of America. 112: 10679-10684. DOI: 10.1073/pnas.1506030112  0.457
2014 Ram G, Chen J, Ross HF, Novick RP. Precisely modulated pathogenicity island interference with late phage gene transcription. Proceedings of the National Academy of Sciences of the United States of America. 111: 14536-41. PMID 25246539 DOI: 10.1073/pnas.1406749111  0.313
2014 Wang B, Zhao A, Novick RP, Muir TW. Activation and inhibition of the receptor histidine kinase AgrC occurs through opposite helical transduction motions. Molecular Cell. 53: 929-40. PMID 24656130 DOI: 10.1016/J.Molcel.2014.02.029  0.524
2013 Quiles-Puchalt N, Tormo-Más MÁ, Campoy S, Toledo-Arana A, Monedero V, Lasa I, Novick RP, Christie GE, Penadés JR. A super-family of transcriptional activators regulates bacteriophage packaging and lysis in Gram-positive bacteria. Nucleic Acids Research. 41: 7260-75. PMID 23771138 DOI: 10.1093/Nar/Gkt508  0.668
2012 Ram G, Chen J, Kumar K, Ross HF, Ubeda C, Damle PK, Lane KD, Penadés JR, Christie GE, Novick RP. Staphylococcal pathogenicity island interference with helper phage reproduction is a paradigm of molecular parasitism. Proceedings of the National Academy of Sciences of the United States of America. 109: 16300-5. PMID 22991467 DOI: 10.1073/Pnas.1204615109  0.654
2012 Mir-Sanchis I, Martínez-Rubio R, Martí M, Chen J, Lasa Í, Novick RP, Tormo-Más MÁ, Penadés JR. Control of Staphylococcus aureus pathogenicity island excision. Molecular Microbiology. 85: 833-45. PMID 22742067 DOI: 10.1111/j.1365-2958.2012.08145.x  0.305
2012 Damle PK, Wall EA, Spilman MS, Dearborn AD, Ram G, Novick RP, Dokland T, Christie GE. The roles of SaPI1 proteins gp7 (CpmA) and gp6 (CpmB) in capsid size determination and helper phage interference. Virology. 432: 277-82. PMID 22709958 DOI: 10.1016/J.Virol.2012.05.026  0.592
2012 Geisinger E, Chen J, Novick RP. Allele-dependent differences in quorum-sensing dynamics result in variant expression of virulence genes in Staphylococcus aureus. Journal of Bacteriology. 194: 2854-64. PMID 22467783 DOI: 10.1128/Jb.06685-11  0.76
2012 Geisinger E, George EA, Chen J, Muir TW, Novick RP. Identification of ligand specificity determinants in AgrC, the Staphylococcus aureus quorum-sensing receptor (Journal of Biological Chemistry (2012) 283, (8930-8938)) Journal of Biological Chemistry. 287: 18588. DOI: 10.1074/jbc.A112.710227  0.761
2011 Benson MA, Lilo S, Wasserman GA, Thoendel M, Smith A, Horswill AR, Fraser J, Novick RP, Shopsin B, Torres VJ. Staphylococcus aureus regulates the expression and production of the staphylococcal superantigen-like secreted proteins in a Rot-dependent manner. Molecular Microbiology. 81: 659-75. PMID 21651625 DOI: 10.1111/J.1365-2958.2011.07720.X  0.317
2011 Ferrer MD, Quiles-Puchalt N, Harwich MD, Tormo-Más MÁ, Campoy S, Barbé J, Lasa I, Novick RP, Christie GE, Penadés JR. RinA controls phage-mediated packaging and transfer of virulence genes in Gram-positive bacteria. Nucleic Acids Research. 39: 5866-78. PMID 21450808 DOI: 10.1093/Nar/Gkr158  0.665
2010 Christie GE, Matthews AM, King DG, Lane KD, Olivarez NP, Tallent SM, Gill SR, Novick RP. The complete genomes of Staphylococcus aureus bacteriophages 80 and 80α--implications for the specificity of SaPI mobilization. Virology. 407: 381-90. PMID 20869739 DOI: 10.1016/J.Virol.2010.08.036  0.598
2010 Viana D, Blanco J, Tormo-Más MA, Selva L, Guinane CM, Baselga R, Corpa J, Lasa I, Novick RP, Fitzgerald JR, Penadés JR. Adaptation of Staphylococcus aureus to ruminant and equine hosts involves SaPI-carried variants of von Willebrand factor-binding protein. Molecular Microbiology. 77: 1583-94. PMID 20860091  0.328
2010 Novick RP, Christie GE, Penadés JR. The phage-related chromosomal islands of Gram-positive bacteria. Nature Reviews. Microbiology. 8: 541-51. PMID 20634809 DOI: 10.1038/Nrmicro2393  0.64
2010 Tormo-Más MA, Mir I, Shrestha A, Tallent SM, Campoy S, Lasa I, Barbé J, Novick RP, Christie GE, Penadés JR. Moonlighting bacteriophage proteins derepress staphylococcal pathogenicity islands. Nature. 465: 779-82. PMID 20473284 DOI: 10.1038/Nature09065  0.645
2010 Herbert S, Ziebandt AK, Ohlsen K, Schäfer T, Hecker M, Albrecht D, Novick R, Götz F. Repair of global regulators in Staphylococcus aureus 8325 and comparative analysis with other clinical isolates. Infection and Immunity. 78: 2877-89. PMID 20212089 DOI: 10.1128/Iai.00088-10  0.417
2009 George Cisar EA, Geisinger E, Muir TW, Novick RP. Symmetric signalling within asymmetric dimers of the Staphylococcus aureus receptor histidine kinase AgrC. Molecular Microbiology. 74: 44-57. PMID 19708918 DOI: 10.1111/J.1365-2958.2009.06849.X  0.778
2009 Ubeda C, Olivarez NP, Barry P, Wang H, Kong X, Matthews A, Tallent SM, Christie GE, Novick RP. Specificity of staphylococcal phage and SaPI DNA packaging as revealed by integrase and terminase mutations. Molecular Microbiology. 72: 98-108. PMID 19347993 DOI: 10.1111/J.1365-2958.2009.06634.X  0.706
2009 Geisinger E, Muir TW, Novick RP. agr receptor mutants reveal distinct modes of inhibition by staphylococcal autoinducing peptides. Proceedings of the National Academy of Sciences of the United States of America. 106: 1216-21. PMID 19147840 DOI: 10.1073/Pnas.0807760106  0.788
2008 Novick RP, Geisinger E. Quorum sensing in staphylococci. Annual Review of Genetics. 42: 541-64. PMID 18713030 DOI: 10.1146/Annurev.Genet.42.110807.091640  0.759
2008 Traber KE, Lee E, Benson S, Corrigan R, Cantera M, Shopsin B, Novick RP. agr function in clinical Staphylococcus aureus isolates. Microbiology (Reading, England). 154: 2265-74. PMID 18667559 DOI: 10.1099/Mic.0.2007/011874-0  0.729
2008 George EA, Novick RP, Muir TW. Cyclic peptide inhibitors of staphylococcal virulence prepared by Fmoc-based thiolactone peptide synthesis. Journal of the American Chemical Society. 130: 4914-24. PMID 18335939 DOI: 10.1021/Ja711126E  0.561
2008 Geisinger E, George EA, Chen J, Muir TW, Novick RP. Identification of ligand specificity determinants in AgrC, the Staphylococcus aureus quorum-sensing receptor. The Journal of Biological Chemistry. 283: 8930-8. PMID 18222919 DOI: 10.1074/Jbc.M710227200  0.782
2008 Ubeda C, Maiques E, Barry P, Matthews A, Tormo MA, Lasa I, Novick RP, Penadés JR. SaPI mutations affecting replication and transfer and enabling autonomous replication in the absence of helper phage. Molecular Microbiology. 67: 493-503. PMID 18086210 DOI: 10.1111/J.1365-2958.2007.06027.X  0.542
2007 Ubeda C, Barry P, Penadés JR, Novick RP. A pathogenicity island replicon in Staphylococcus aureus replicates as an unstable plasmid. Proceedings of the National Academy of Sciences of the United States of America. 104: 14182-8. PMID 17693549 DOI: 10.1073/Pnas.0705994104  0.537
2007 Chen J, Novick RP. svrA, a multi-drug exporter, does not control agr. Microbiology (Reading, England). 153: 1604-8. PMID 17464075 DOI: 10.1099/mic.0.2007/006247-0  0.308
2006 Geisinger E, Adhikari RP, Jin R, Ross HF, Novick RP. Inhibition of rot translation by RNAIII, a key feature of agr function. Molecular Microbiology. 61: 1038-48. PMID 16879652 DOI: 10.1111/J.1365-2958.2006.05292.X  0.721
2006 Yao J, Zhong J, Fang Y, Geisinger E, Novick RP, Lambowitz AM. Use of targetrons to disrupt essential and nonessential genes in Staphylococcus aureus reveals temperature sensitivity of Ll.LtrB group II intron splicing. Rna (New York, N.Y.). 12: 1271-81. PMID 16741231 DOI: 10.1261/Rna.68706  0.727
2006 Traber K, Novick R. A slipped-mispairing mutation in AgrA of laboratory strains and clinical isolates results in delayed activation of agr and failure to translate delta- and alpha-haemolysins. Molecular Microbiology. 59: 1519-30. PMID 16468992 DOI: 10.1111/J.1365-2958.2006.04986.X  0.74
2005 Wright JS, Traber KE, Corrigan R, Benson SA, Musser JM, Novick RP. The agr radiation: an early event in the evolution of staphylococci. Journal of Bacteriology. 187: 5585-94. PMID 16077103 DOI: 10.1128/Jb.187.16.5585-5594.2005  0.735
2005 Ji G, Pei W, Zhang L, Qiu R, Lin J, Benito Y, Lina G, Novick RP. Staphylococcus intermedius produces a functional agr autoinducing peptide containing a cyclic lactone. Journal of Bacteriology. 187: 3139-50. PMID 15838041 DOI: 10.1128/JB.187.9.3139-3150.2005  0.313
2005 Ubeda C, Maiques E, Knecht E, Lasa I, Novick RP, Penadés JR. Antibiotic-induced SOS response promotes horizontal dissemination of pathogenicity island-encoded virulence factors in staphylococci. Molecular Microbiology. 56: 836-44. PMID 15819636 DOI: 10.1111/j.1365-2958.2005.04584.x  0.316
2005 Wright JS, Jin R, Novick RP. Transient interference with staphylococcal quorum sensing blocks abscess formation. Proceedings of the National Academy of Sciences of the United States of America. 102: 1691-6. PMID 15665088 DOI: 10.1073/pnas.0407661102  0.312
2004 Weinrick B, Dunman PM, McAleese F, Murphy E, Projan SJ, Fang Y, Novick RP. Effect of mild acid on gene expression in Staphylococcus aureus. Journal of Bacteriology. 186: 8407-23. PMID 15576791 DOI: 10.1128/Jb.186.24.8407-8423.2004  0.767
2004 Wright JS, Lyon GJ, George EA, Muir TW, Novick RP. Hydrophobic interactions drive ligand-receptor recognition for activation and inhibition of staphylococcal quorum sensing. Proceedings of the National Academy of Sciences of the United States of America. 101: 16168-73. PMID 15528279 DOI: 10.1073/Pnas.0404039101  0.711
2004 Charpentier E, Anton AI, Barry P, Alfonso B, Fang Y, Novick RP. Novel cassette-based shuttle vector system for gram-positive bacteria. Applied and Environmental Microbiology. 70: 6076-85. PMID 15466553 DOI: 10.1128/Aem.70.10.6076-6085.2004  0.699
2004 Mangold M, Siller M, Roppenser B, Vlaminckx BJ, Penfound TA, Klein R, Novak R, Novick RP, Charpentier E. Synthesis of group A streptococcal virulence factors is controlled by a regulatory RNA molecule. Molecular Microbiology. 53: 1515-27. PMID 15387826 DOI: 10.1111/j.1365-2958.2004.04222.x  0.601
2004 Lyon GJ, Novick RP. Peptide signaling in Staphylococcus aureus and other Gram-positive bacteria. Peptides. 25: 1389-403. PMID 15374643 DOI: 10.1016/J.Peptides.2003.11.026  0.606
2002 Lyon GJ, Wright JS, Muir TW, Novick RP. Key determinants of receptor activation in the agr autoinducing peptides of Staphylococcus aureus. Biochemistry. 41: 10095-104. PMID 12146974 DOI: 10.1021/Bi026049U  0.712
2002 Zhang L, Gray L, Novick RP, Ji G. Transmembrane topology of AgrB, the protein involved in the post-translational modification of AgrD in Staphylococcus aureus Journal of Biological Chemistry. 277: 34736-34742. PMID 12122003 DOI: 10.1074/jbc.M205367200  0.337
2002 Vojtov N, Ross HF, Novick RP. Global repression of exotoxin synthesis by staphylococcal superantigens. Proceedings of the National Academy of Sciences of the United States of America. 99: 10102-7. PMID 12110733 DOI: 10.1073/Pnas.152152499  0.731
2002 Lyon GJ, Wright JS, Christopoulos A, Novick RP, Muir TW. Reversible and specific extracellular antagonism of receptor-histidine kinase signaling. The Journal of Biological Chemistry. 277: 6247-53. PMID 11733525 DOI: 10.1074/Jbc.M109989200  0.702
2001 Herbert S, Barry P, Novick RP. Subinhibitory clindamycin differentially inhibits transcription of exoprotein genes in Staphylococcus aureus. Infection and Immunity. 69: 2996-3003. PMID 11292717 DOI: 10.1128/Iai.69.5.2996-3003.2001  0.533
2000 Lyon GJ, Mayville P, Muir TW, Novick RP. Rational design of a global inhibitor of the virulence response in Staphylococcus aureus, based in part on localization of the site of inhibition to the receptor-histidine kinase, AgrC. Proceedings of the National Academy of Sciences of the United States of America. 97: 13330-5. PMID 11087872 DOI: 10.1073/Pnas.97.24.13330  0.729
2000 Jarraud S, Lyon GJ, Figueiredo AM, Lina G, Gérard L, Vandenesch F, Etienne J, Muir TW, Novick RP. Exfoliatin-producing strains define a fourth agr specificity group in Staphylococcus aureus. Journal of Bacteriology. 182: 6517-22. PMID 11053400 DOI: 10.1128/Jb.182.22.6517-6522.2000  0.7
1999 Novick RP, Muir TW. Virulence gene regulation by peptides in staphylococci and other Gram-positive bacteria. Current Opinion in Microbiology. 2: 40-5. PMID 10047551 DOI: 10.1016/S1369-5274(99)80007-1  0.527
1999 Mayville P, Ji G, Beavis R, Yang H, Goger M, Novick RP, Muir TW. Structure-activity analysis of synthetic autoinducing thiolactone peptides from Staphylococcus aureus responsible for virulence. Proceedings of the National Academy of Sciences of the United States of America. 96: 1218-23. PMID 9990004 DOI: 10.1073/Pnas.96.4.1218  0.55
1998 Lindsay JA, Ruzin A, Ross HF, Kurepina N, Novick RP. The gene for toxic shock toxin is carried by a family of mobile pathogenicity islands in Staphylococcus aureus Molecular Microbiology. 29: 527-543. PMID 9720870 DOI: 10.1046/j.1365-2958.1998.00947.x  0.309
1998 Lina G, Jarraud S, Ji G, Greenland T, Pedraza A, Etienne J, Novick RP, Vandenesch F. Transmembrane topology and histidine protein kinase activity of AgrC, the agr signal receptor in Staphylococcus aureus Molecular Microbiology. 28: 655-662. PMID 9632266 DOI: 10.1046/j.1365-2958.1998.00830.x  0.302
1997 Ji G, Beavis R, Novick RP. Bacterial interference caused by autoinducing peptide variants Science. 276: 2027-2030. PMID 9197262 DOI: 10.1126/science.276.5321.2027  0.334
1997 Novick R. The biology of plasmids Trends in Genetics. 13: 82-83. DOI: 10.1016/S0168-9525(97)84646-X  0.304
1995 Ji G, Beavis RC, Novick RP. Cell density control of staphylococcal virulence mediated by an octapeptide pheromone Proceedings of the National Academy of Sciences of the United States of America. 92: 12055-12059. PMID 8618843 DOI: 10.1073/pnas.92.26.12055  0.307
1994 Rasooly A, Wang P, Novick R. Replication-specific conversion of the Staphylococcus aureus pT181 initiator protein from an active homodimer to an inactive heterodimer. The Embo Journal. 13: 5245-5251. DOI: 10.1002/J.1460-2075.1994.Tb06856.X  0.356
1993 Bargonetti J, Wang P, Novick R. Measurement of gene expression by translational coupling: effect of copy mutations on pT181 initiator synthesis. The Embo Journal. 12: 3659-3667. DOI: 10.1002/j.1460-2075.1993.tb06040.x  0.603
1992 Patel AH, Kornblum J, Kreiswirth B, Novick R, Foster TJ. Regulation of the protein A-encoding gene in Staphylococcus aureus Gene. 114: 25-34. PMID 1587482 DOI: 10.1016/0378-1119(92)90703-R  0.442
1991 Sloane R, Azavedo JC, Arbuthnott JP, Hartigan PJ, Kreiswirth B, Novick R, Foster TJ. A toxic shock syndrome toxin mutant ofStaphylococcus aureusisolated by allelic replacement lacks virulence in a rabbit uterine model Fems Microbiology Letters. 78: 239-244. DOI: 10.1111/J.1574-6968.1991.Tb04449.X  0.372
1990 Noirot P, Bargonetti J, Novick RP. Initiation of rolling-circle replication in pT181 plasmid: Initiator protein enhances cruciform extrusion at the origin Proceedings of the National Academy of Sciences of the United States of America. 87: 8560-8564. PMID 2236066 DOI: 10.1073/Pnas.87.21.8560  0.593
1988 Projan SJ, Novick R. Comparative analysis of five related Staphylococcal plasmids. Plasmid. 19: 203-221. PMID 2852816 DOI: 10.1016/0147-619X(88)90039-X  0.369
1988 Peng HL, Novick RP, Kreiswirth B, Kornblum J, Schlievert P. Cloning, characterization, and sequencing of an accessory gene regulator (agr) in Staphylococcus aureus. Journal of Bacteriology. 170: 4365-72. PMID 2457579 DOI: 10.1128/Jb.170.9.4365-4372.1988  0.309
1980 Novick R, Sanchez-Rivas C, Gruss A, Edelman I. Involvement of the cell envelope in plasmid maintenance: plasmid curing during the regeneration of protoplasts. Plasmid. 3: 348-358. PMID 6927765 DOI: 10.1016/0147-619X(80)90048-7  0.328
1978 Novick RP, Hoppensteadt FC. On plasmid incompatibility. Plasmid. 1: 421-34. PMID 372974 DOI: 10.1016/0147-619X(78)90001-X  0.532
1975 Novick R, Zouzias D, Rush M. Nucleic acid hybridization analysis of an integrated plasmid in Staphylococcus aureus. Journal of Bacteriology. 124: 1424-1428. PMID 1194240 DOI: 10.1128/Jb.124.3.1424-1428.1975  0.334
1975 Rush M, Novick R, DeLap R. Detection and quantitation of Staphylococcus aureus penicillinase plasmid deoxyribonucleic acid by reassociation kinetics. Journal of Bacteriology. 124: 1417-1423. PMID 1194239 DOI: 10.1128/Jb.124.3.1417-1423.1975  0.325
1973 Zouzias D, Rush M, Murphy E, Novick R. Studies on plasmid replication. II. In vivo transcription and its control in penicillinase plasmids from Staphylococcus aureus. Journal of Molecular Biology. 79: 471-480. PMID 4758063 DOI: 10.1016/0022-2836(73)90399-9  0.38
1967 Novick R. Properties of a cryptic high-frequency transducing phage in Staphylococcus aureus. Virology. 33: 155-166. PMID 4227577 DOI: 10.1016/0042-6822(67)90105-5  0.373
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