Stephen Cusack - Publications

EMBL, Heidelberg, Baden-Württemberg, Germany 

69 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Koliopoulos MG, Lethier M, van der Veen AG, Haubrich K, Hennig J, Kowalinski E, Stevens RV, Martin SR, Reis E Sousa C, Cusack S, Rittinger K. Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition. Nature Communications. 9: 1820. PMID 29739942 DOI: 10.1038/S41467-018-04214-8  0.64
2016 Reguera J, Gerlach P, Rosenthal M, Gaudon S, Coscia F, Günther S, Cusack S. Comparative Structural and Functional Analysis of Bunyavirus and Arenavirus Cap-Snatching Endonucleases. Plos Pathogens. 12: e1005636. PMID 27304209 DOI: 10.1371/Journal.Ppat.1005636  0.4
2016 Sonoiki E, Palencia A, Guo D, Ahyong V, Dong C, Li X, Hernandez VS, Zhang YK, Choi W, Gut J, Legac J, Cooper R, Alley MR, Freund YR, DeRisi J, ... Cusack S, et al. Anti-malarial benzoxaboroles target P. falciparum leucyl-tRNA synthetase. Antimicrobial Agents and Chemotherapy. PMID 27270277 DOI: 10.1128/Aac.00820-16  0.4
2016 Uchikawa E, Lethier M, Malet H, Brunel J, Gerlier D, Cusack S. Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5. Molecular Cell. 62: 586-602. PMID 27203181 DOI: 10.1016/J.Molcel.2016.04.021  0.64
2015 Thierry E, Guilligay D, Kosinski J, Bock T, Gaudon S, Round A, Pflug A, Hengrung N, El Omari K, Baudin F, Hart DJ, Beck M, Cusack S. Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains. Molecular Cell. PMID 26711008 DOI: 10.1016/J.Molcel.2015.11.016  0.4
2015 Hengrung N, El Omari K, Serna Martin I, Vreede FT, Cusack S, Rambo RP, Vonrhein C, Bricogne G, Stuart DI, Grimes JM, Fodor E. Crystal structure of the RNA-dependent RNA polymerase from influenza C virus. Nature. 527: 114-7. PMID 26503046 DOI: 10.1038/Nature15525  0.4
2015 Roch FF, Hinterkörner G, Menke J, Tang GQ, Cusack S, Butzendobler B, Buschmann H, Datta K, Wolkerstorfer A. An RNA Hybridization Assay for Screening Influenza A Virus Polymerase Inhibitors Using the Entire Ribonucleoprotein Complex. Assay and Drug Development Technologies. 13: 488-506. PMID 26461433 DOI: 10.1089/Adt.2015.668  0.4
2015 Louber J, Brunel J, Uchikawa E, Cusack S, Gerlier D. Kinetic discrimination of self/non-self RNA by the ATPase activity of RIG-I and MDA5. Bmc Biology. 13: 54. PMID 26215161 DOI: 10.1186/S12915-015-0166-9  0.64
2015 Zhao H, Palencia A, Seiradake E, Ghaemi Z, Cusack S, Luthey-Schulten Z, Martinis S. Analysis of the Resistance Mechanism of a Benzoxaborole Inhibitor Reveals Insight into the Leucyl-tRNA Synthetase Editing Mechanism Acs Chemical Biology. 10: 2277-2285. DOI: 10.1021/acschembio.5b00291  0.4
2014 Reich S, Guilligay D, Pflug A, Malet H, Berger I, Crépin T, Hart D, Lunardi T, Nanao M, Ruigrok RW, Cusack S. Structural insight into cap-snatching and RNA synthesis by influenza polymerase. Nature. 516: 361-6. PMID 25409151 DOI: 10.1038/Nature14009  0.4
2014 Bousset L, Mary C, Brooks MA, Scherrer A, Strub K, Cusack S. Crystal structure of a signal recognition particle Alu domain in the elongation arrest conformation. Rna (New York, N.Y.). 20: 1955-62. PMID 25336584 DOI: 10.1261/Rna.047209.114  0.4
2014 Louber J, Kowalinski E, Bloyet LM, Brunel J, Cusack S, Gerlier D. RIG-I self-oligomerization is either dispensable or very transient for signal transduction. Plos One. 9: e108770. PMID 25259935 DOI: 10.1371/Journal.Pone.0108770  0.64
2014 Xiol J, Spinelli P, Laussmann MA, Homolka D, Yang Z, Cora E, Couté Y, Conn S, Kadlec J, Sachidanandam R, Kaksonen M, Cusack S, Ephrussi A, Pillai RS. RNA clamping by Vasa assembles a piRNA amplifier complex on transposon transcripts. Cell. 157: 1698-711. PMID 24910301 DOI: 10.1016/J.Cell.2014.05.018  0.4
2014 Dias J, Van Nguyen N, Georgiev P, Gaub A, Brettschneider J, Cusack S, Kadlec J, Akhtar A. Structural analysis of the KANSL1/WDR5/ KANSL2 complex reveals that WDR5 is required for efficient assembly and chromatin targeting of the NSL complex Genes and Development. 28: 929-942. PMID 24788516 DOI: 10.1101/Gad.240200.114  0.4
2014 Kyrieleis OJ, Chang J, de la Peña M, Shuman S, Cusack S. Crystal structure of vaccinia virus mRNA capping enzyme provides insights into the mechanism and evolution of the capping apparatus. Structure (London, England : 1993). 22: 452-65. PMID 24607143 DOI: 10.1016/J.Str.2013.12.014  0.4
2014 Reguera J, Cusack S, Kolakofsky D. Segmented negative strand RNA virus nucleoprotein structure. Current Opinion in Virology. 5: 7-15. PMID 24486721 DOI: 10.1016/J.Coviro.2014.01.003  0.44
2014 Louber J, Kowalinski E, Bloyet L, Brunel J, Cusack S, Gerlier D. Lack of RNA induced RIG-I oligomerization in cellula as detected using PCA. Plos One. DOI: 10.1371/Journal.Pone.0108770.G005  0.64
2013 Pautus S, Sehr P, Lewis J, Fortuné A, Wolkerstorfer A, Szolar O, Guilligay D, Lunardi T, Décout JL, Cusack S. New 7-methylguanine derivatives targeting the influenza polymerase PB2 cap-binding domain. Journal of Medicinal Chemistry. 56: 8915-30. PMID 24134208 DOI: 10.1021/Jm401369Y  0.4
2013 Datta K, Wolkerstorfer A, Szolar OH, Cusack S, Klumpp K. Characterization of PA-N terminal domain of Influenza A polymerase reveals sequence specific RNA cleavage. Nucleic Acids Research. 41: 8289-99. PMID 23847103 DOI: 10.1093/Nar/Gkt603  0.4
2013 Li L, Palencia A, Lukk T, Li Z, Luthey-Schulten ZA, Cusack S, Martinis SA, Boniecki MT. Leucyl-tRNA synthetase editing domain functions as a molecular rheostat to control codon ambiguity in Mycoplasma pathogens. Proceedings of the National Academy of Sciences of the United States of America. 110: 3817-22. PMID 23431144 DOI: 10.1073/Pnas.1218374110  0.4
2013 Hernandez V, Crépin T, Palencia A, Cusack S, Akama T, Baker SJ, Bu W, Feng L, Freund YR, Liu L, Meewan M, Mohan M, Mao W, Rock FL, Sexton H, et al. Discovery of a novel class of boron-based antibacterials with activity against gram-negative bacteria. Antimicrobial Agents and Chemotherapy. 57: 1394-403. PMID 23295920 DOI: 10.1128/Aac.02058-12  0.4
2012 Kolakofsky D, Kowalinski E, Cusack S. A structure-based model of RIG-I activation. Rna (New York, N.Y.). 18: 2118-27. PMID 23118418 DOI: 10.1261/Rna.035949.112  0.64
2012 Hallacli E, Lipp M, Georgiev P, Spielman C, Cusack S, Akhtar A, Kadlec J. Msl1-Mediated Dimerization of the Dosage Compensation Complex Is Essential for Male X-Chromosome Regulation in Drosophila Molecular Cell. 48: 587-600. PMID 23084835 DOI: 10.1016/J.Molcel.2012.09.014  0.4
2012 Szolajska E, Burmeister WP, Zochowska M, Nerlo B, Andreev I, Schoehn G, Andrieu JP, Fender P, Naskalska A, Zubieta C, Cusack S, Chroboczek J. The structural basis for the integrity of adenovirus Ad3 dodecahedron. Plos One. 7: e46075. PMID 23049939 DOI: 10.1371/Journal.Pone.0046075  0.4
2012 Kowalinski E, Zubieta C, Wolkerstorfer A, Szolar OH, Ruigrok RW, Cusack S. Structural analysis of specific metal chelating inhibitor binding to the endonuclease domain of influenza pH1N1 (2009) polymerase. Plos Pathogens. 8: e1002831. PMID 22876177 DOI: 10.1371/Journal.Ppat.1002831  0.4
2012 Palencia A, Crépin T, Vu MT, Lincecum TL, Martinis SA, Cusack S. Structural dynamics of the aminoacylation and proofreading functional cycle of bacterial leucyl-tRNA synthetase Nature Structural and Molecular Biology. 19: 677-684. PMID 22683997 DOI: 10.1038/Nsmb.2317  0.4
2012 Kowalinski E, Louber J, Gerlier D, Cusack S. [RIG-I: a viral RNA detector molecular switch]. Medecine Sciences : M/S. 28: 136-8. PMID 22377296 DOI: 10.1051/Medsci/2012282006  0.64
2011 Kowalinski E, Lunardi T, McCarthy AA, Louber J, Brunel J, Grigorov B, Gerlier D, Cusack S. Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA. Cell. 147: 423-35. PMID 22000019 DOI: 10.1016/J.Cell.2011.09.039  0.64
2011 Russi S, Juers DH, Sanchez-Weatherby J, Pellegrini E, Mossou E, Forsyth VT, Huet J, Gobbo A, Felisaz F, Moya R, McSweeney SM, Cusack S, Cipriani F, Bowler MW. Inducing phase changes in crystals of macromolecules: status and perspectives for controlled crystal dehydration. Journal of Structural Biology. 175: 236-43. PMID 21385612 DOI: 10.1016/J.Jsb.2011.03.002  0.4
2011 Crepin T, Peterson F, Haertlein M, Jensen D, Wang C, Cusack S, Kron M. A hybrid structural model of the complete Brugia malayi cytoplasmic asparaginyl-tRNA synthetase Journal of Molecular Biology. 405: 1056-1069. PMID 21134380 DOI: 10.1016/J.Jmb.2010.11.049  0.4
2010 Mourão A, Varrot A, Mackereth CD, Cusack S, Sattler M. Structure and RNA recognition by the snRNA and snoRNA transport factor PHAX. Rna (New York, N.Y.). 16: 1205-16. PMID 20430857 DOI: 10.1261/Rna.2009910  0.4
2010 Chenavas S, Guilligay D, Cusack S, Hart DJ, Ruigrok RWH, Crepin T. Avancées dans l'étude structurale et la compréhension moléculaire du mécanisme de transcription du virus de la grippe Virologie. 14: 435-445. DOI: 10.1684/Vir.2010.0328  0.4
2007 Rock FL, Mao W, Yaremchuk A, Tukalo M, Crépin T, Zhou H, Zhang YK, Hernandez V, Akama T, Baker SJ, Plattner JJ, Shapiro L, Martinis SA, Benkovic SJ, Cusack S, et al. An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site. Science (New York, N.Y.). 316: 1759-61. PMID 17588934 DOI: 10.1126/Science.1142189  0.4
2006 Banci L, Bertini I, Cusack S, de Jong RN, Heinemann U, Jones EY, Kozielski F, Maskos K, Messerschmidt A, Owens R, Perrakis A, Poterszman A, Schneider G, Siebold C, Silman I, et al. First steps towards effective methods in exploiting high-throughput technologies for the determination of human protein structures of high biomedical value. Acta Crystallographica. Section D, Biological Crystallography. 62: 1208-17. PMID 17001097 DOI: 10.1107/S0907444906029350  0.4
2006 Beteva A, Cipriani F, Cusack S, Delageniere S, Gabadinho J, Gordon EJ, Guijarro M, Hall DR, Larsen S, Launer L, Lavault CB, Leonard GA, Mairs T, McCarthy A, McCarthy J, et al. High-throughput sample handling and data collection at synchrotrons: embedding the ESRF into the high-throughput gene-to-structure pipeline. Acta Crystallographica. Section D, Biological Crystallography. 62: 1162-9. PMID 17001093 DOI: 10.1107/S0907444906032859  0.4
2006 Zubieta C, Blanchoin L, Cusack S. Structural and biochemical characterization of a human adenovirus 2/12 penton base chimera. The Febs Journal. 273: 4336-45. PMID 16939624 DOI: 10.1111/J.1742-4658.2006.05430.X  0.4
2006 Sukuru SC, Crepin T, Milev Y, Marsh LC, Hill JB, Anderson RJ, Morris JC, Rohatgi A, O'Mahony G, Grøtli M, Danel F, Page MG, Härtlein M, Cusack S, Kron MA, et al. Discovering new classes of Brugia malayi asparaginyl-tRNA synthetase inhibitors and relating specificity to conformational change. Journal of Computer-Aided Molecular Design. 20: 159-78. PMID 16645791 DOI: 10.1007/S10822-006-9043-5  0.4
2005 Tukalo M, Yaremchuk A, Fukunaga R, Yokoyama S, Cusack S. The crystal structure of leucyl-tRNA synthetase complexed with tRNALeu in the post-transfer-editing conformation. Nature Structural & Molecular Biology. 12: 923-30. PMID 16155583 DOI: 10.1038/Nsmb986  0.4
2005 Fabry CM, Rosa-Calatrava M, Conway JF, Zubieta C, Cusack S, Ruigrok RW, Schoehn G. A quasi-atomic model of human adenovirus type 5 capsid. The Embo Journal. 24: 1645-54. PMID 15861131 DOI: 10.1038/Sj.Emboj.7600653  0.4
2005 Zubieta C, Schoehn G, Chroboczek J, Cusack S. The structure of the human adenovirus 2 penton. Molecular Cell. 17: 121-35. PMID 15629723 DOI: 10.1016/J.Molcel.2004.11.041  0.4
2004 Kadlec J, Izaurralde E, Cusack S. The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3. Nature Structural & Molecular Biology. 11: 330-7. PMID 15004547 DOI: 10.1038/Nsmb741  0.4
2003 Lincecum TL, Tukalo M, Yaremchuk A, Mursinna RS, Williams AM, Sproat BS, Van Den Eynde W, Link A, Van Calenbergh S, Grøtli M, Martinis SA, Cusack S. Structural and mechanistic basis of pre- and posttransfer editing by leucyl-tRNA synthetase. Molecular Cell. 11: 951-63. PMID 12718881 DOI: 10.1016/S1097-2765(03)00098-4  0.4
2002 Mazza C, Segref A, Mattaj LW, Cusack S. Co-crystallization of the human nuclear cap-binding complex with a m7GpppG cap analogue using protein engineering Acta Crystallographica Section D: Biological Crystallography. 58: 2194-2197. PMID 12454499 DOI: 10.1107/S0907444902015445  0.4
2002 Zeth K, Ravelli RB, Paal K, Cusack S, Bukau B, Dougan DA. Structural analysis of the adaptor protein ClpS in complex with the N-terminal domain of ClpA Nature Structural Biology. 9: 906-911. PMID 12426582 DOI: 10.1038/Nsb869  0.4
2002 Mazza C, Segref A, Mattaj IW, Cusack S. Large-scale induced fit recognition of an m7GpppG cap analogue by the human nuclear cap-binding complex Embo Journal. 21: 5548-5557. PMID 12374755 DOI: 10.1093/Emboj/Cdf538  0.4
2002 Zeth K, Dougan DA, Cusack S, Bukau B, Ravelli RB. Crystallization and preliminary X-ray analysis of the Escherichia coli adaptor protein ClpS, free and in complex with the N-terminal domain of ClpA Acta Crystallographica Section D: Biological Crystallography. 58: 1207-1210. PMID 12077445 DOI: 10.1107/S0907444902006960  0.4
2000 Van Raaij MJ, Chouin E, Van der Zandt H, Bergelson JM, Cusack S. Dimeric structure of the coxsackievirus and adenovirus receptor D1 domain at 1.7 Å resolution Structure. 8: 1147-1155. PMID 11080637 DOI: 10.1016/S0969-2126(00)00528-1  0.4
2000 Monaco-Malbet S, Berthet-Colominas C, Novelli A, Battaï N, Piga N, Cheynet V, Mallet F, Cusack S. Mutual conformational adaptations in antigen and antibody upon complex formation between an Fab and HIV-1 capsid protein p24. Structure (London, England : 1993). 8: 1069-77. PMID 11080628 DOI: 10.1016/S0969-2126(00)00507-4  0.4
1999 Perrakis A, Cipriani F, Castagna JC, Claustre L, Burghammer M, Riekel C, Cusack S. Protein microcrystals and the design of a microdiffractometer: Current experience and plans at EMBL and ESRF/ID13 Acta Crystallographica Section D: Biological Crystallography. 55: 1765-1770. PMID 10531527 DOI: 10.1107/S0907444999009348  0.4
1994 Elster C, Fourest E, Baudin F, Larsen K, Cusack S, Ruigrok RWH. A small percentage of influenza virus M1 protein contains zinc but zinc does not influence in vitro M1-RNA interaction Journal of General Virology. 75: 37-42. PMID 8113738 DOI: 10.1099/0022-1317-75-1-37  0.4
1994 Nardi F, Doster W, Tidor B, Karplus M, Cusack S, Smith J. Dynamics of tRNA: Experimental Neutron Spectra Compared with a Normal Mode Analysis Israel Journal of Chemistry. 34: 233-238. DOI: 10.1002/Ijch.199400026  0.48
1993 Burmeister WP, Henrissat B, Bosso C, Cusack S, Ruigrok RW. Influenza B virus neuraminidase can synthesize its own inhibitor. Structure (London, England : 1993). 1: 19-26. PMID 8069621 DOI: 10.1016/0969-2126(93)90005-2  0.4
1992 Stouten PFW, Sander C, Ruigrok RWH, Cusack S. New triple-helical model for the shaft of the adenovirus fibre Journal of Molecular Biology. 226: 1073-1084. PMID 1518045 DOI: 10.1016/0022-2836(92)91053-R  0.4
1991 Doster W, Cusack S, Petry W. Structural dynamics of proteins, scaling behaviour and liquid glass transition Journal of Non-Crystalline Solids. 357-361. DOI: 10.1016/0022-3093(91)90328-4  0.32
1990 Doster W, Cusack S, Petry W. Dynamic instability of liquidlike motions in a globular protein observed by inelastic neutron scattering. Physical Review Letters. 65: 1080-1083. PMID 10043100 DOI: 10.1103/Physrevlett.65.1080  0.32
1990 Smith J, Cusack S, Tidor B, Karplus M. Inelastic neutron scattering analysis of low‐frequency motions in proteins: Harmonic and damped harmonic models of bovine pancreatic tryspin inhibitor The Journal of Chemical Physics. 93: 2974-2991. DOI: 10.1063/1.458885  0.48
1989 Smith J, Kuczera K, Tidor B, Doster W, Cusack S, Karplus M. Internal dynamics of globular proteins: Comparison of neutron scattering measurements and theoretical models Physica B: Physics of Condensed Matter. 156: 437-443. DOI: 10.1016/0921-4526(89)90699-6  0.4
1988 Weis W, Brown JH, Cusack S, Paulson JC, Skehel JJ, Wiley DC. Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid Nature. 333: 426-431. PMID 3374584 DOI: 10.1038/333426A0  0.4
1988 Cusack S, Smith J, Finney J, Tidor B, Karplus M. Inelastic neutron scattering analysis of picosecond internal protein dynamics. Comparison of harmonic theory with experiment. Journal of Molecular Biology. 202: 903-8. PMID 2459399 DOI: 10.1016/0022-2836(88)90566-9  0.4
1987 Smith J, Cusack S, Poole P, Finney J. Direct measurement of hydration-related dynamic changes in lysozyme using inelastic neutron scattering spectroscopy. Journal of Biomolecular Structure & Dynamics. 4: 583-588. PMID 3271457 DOI: 10.1080/07391102.1987.10507662  0.48
1986 Smith J, Cusack S, Pezzeca U, Brooks B, Karplus M. Inelastic neutron scattering analysis of low frequency motion in proteins: A normal mode study of the bovine pancreatic trypsin inhibitor The Journal of Chemical Physics. 85: 3636-3654. DOI: 10.1063/1.450935  0.48
1986 Cusack S, Smith J, Finney J, Karplus M, Trewhella J. Low frequency dynamics of proteins studied by neutron time-of-flight spectroscopy Physica B+C. 136: 256-259. DOI: 10.1016/S0378-4363(86)80069-9  0.48
1986 Cusack S, Smith J, Finney J, Karplus M, Trewhella J. Low frequency dynamics of proteins studied by neutron time-of-flight spectroscopy Physica B+C. 136: 256-259. DOI: 10.1016/S0378-4363(86)80069-9  0.4
1985 Cusack S, Ruigrok RWH, Krygsman PCJ, Mellema JE. Structure and composition of influenza virus: A small-angle neutron scattering study Journal of Molecular Biology. 186: 565-582. PMID 4093979 DOI: 10.1016/0022-2836(85)90131-7  0.4
1984 Hewat EA, Cusack S, Ruigrok RWH, Verwey C. Low resolution structure of the influenza C glycoprotein determined by electron microscopy Journal of Molecular Biology. 175: 175-193. PMID 6726808 DOI: 10.1016/0022-2836(84)90473-X  0.4
1984 Engelman DM, Dianoux AJ, Cusack S, Jacrot B. Inelastic neutron scattering studies of hexokinase in solution Basic Life Sciences. 27: 365-380. PMID 6712571 DOI: 10.1007/978-1-4899-0375-4_22  0.4
1983 Oostergetel GT, Mellema JE, Cusack S, Klug A. Solution scattering study on the structure of alfalfa mosaic virus strain VRU Journal of Molecular Biology. 171: 157-173. PMID 6655691 DOI: 10.1016/S0022-2836(83)80351-9  0.4
1983 Cusack S, Oostergetel GT, Krijgsman PCJ, Mellema JE, Klug A. Structure of the top a-t component of alfalfa mosaic virus a non-icosahedral virion Journal of Molecular Biology. 171: 139-155. PMID 6655690 DOI: 10.1016/S0022-2836(83)80350-7  0.4
1982 Jacrot B, Cusack S, Dianoux AJ, Engelman DM. Inelastic neutron scattering analysis of hexokinase dynamics and its modification on binding of glucose Nature. 300: 84-86. PMID 6752726 DOI: 10.1038/300084A0  0.4
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