Timothy M. Lohman - Publications

Affiliations: 
Washington University, Saint Louis, St. Louis, MO 
Area:
DNA helises, SSB proteins, DNA repair
Website:
http://biochem.wustl.edu/faculty/faculty/timothy-lohman

154 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Ordabayev YA, Nguyen B, Niedziela-Majka A, Lohman TM. Regulation of UvrD Helicase Activity by MutL. Journal of Molecular Biology. PMID 30171840 DOI: 10.1016/j.jmb.2018.08.022  0.6
2018 Antony E, Lohman TM. Dynamics of E. coli single stranded DNA binding (SSB) protein-DNA complexes. Seminars in Cell & Developmental Biology. PMID 29588158 DOI: 10.1016/j.semcdb.2018.03.017  0.6
2017 Tomko EJ, Lohman TM. Modulation of Escherichia coli UvrD Single-Stranded DNA Translocation by DNA Base Composition. Biophysical Journal. 113: 1405-1415. PMID 28978435 DOI: 10.1016/j.bpj.2017.08.023  1
2016 Simon MJ, Sokoloski J, Hao L, Weiland E, Lohman TM. Processive DNA Unwinding by RecBCD Helicase in the Absence of Canonical Motor Translocation. Journal of Molecular Biology. PMID 27422010 DOI: 10.1016/j.jmb.2016.07.002  1
2016 Sokoloski JE, Kozlov AG, Galletto R, Lohman TM. Chemo-mechanical pushing of proteins along single-stranded DNA. Proceedings of the National Academy of Sciences of the United States of America. PMID 27185951 DOI: 10.1073/pnas.1602878113  1
2015 Suksombat S, Khafizov R, Kozlov AG, Lohman TM, Chemla YR. Structural dynamics of E. coli single-stranded DNA binding protein reveal DNA wrapping and unwrapping pathways. Elife. 4. PMID 26305498 DOI: 10.7554/eLife.08193  1
2015 Comstock MJ, Whitley KD, Jia H, Sokoloski J, Lohman TM, Ha T, Chemla YR. Protein structure. Direct observation of structure-function relationship in a nucleic acid-processing enzyme. Science (New York, N.Y.). 348: 352-4. PMID 25883359 DOI: 10.1126/science.aaa0130  1
2015 Kozlov AG, Weiland E, Mittal A, Waldman V, Antony E, Fazio N, Pappu RV, Lohman TM. Intrinsically disordered C-terminal tails of E. coli single-stranded DNA binding protein regulate cooperative binding to single-stranded DNA. Journal of Molecular Biology. 427: 763-74. PMID 25562210 DOI: 10.1016/j.jmb.2014.12.020  1
2014 Nguyen B, Sokoloski J, Galletto R, Elson EL, Wold MS, Lohman TM. Diffusion of human replication protein A along single-stranded DNA. Journal of Molecular Biology. 426: 3246-61. PMID 25058683 DOI: 10.1016/j.jmb.2014.07.014  1
2014 Lee KS, Marciel AB, Kozlov AG, Schroeder CM, Lohman TM, Ha T. Ultrafast redistribution of E. coli SSB along long single-stranded DNA via intersegment transfer. Journal of Molecular Biology. 426: 2413-21. PMID 24792418 DOI: 10.1016/j.jmb.2014.04.023  1
2013 Antony E, Weiland E, Yuan Q, Manhart CM, Nguyen B, Kozlov AG, McHenry CS, Lohman TM. Multiple C-terminal tails within a single E. coli SSB homotetramer coordinate DNA replication and repair. Journal of Molecular Biology. 425: 4802-19. PMID 24021816 DOI: 10.1016/j.jmb.2013.08.021  1
2013 Qiu Y, Antony E, Doganay S, Koh HR, Lohman TM, Myong S. Srs2 prevents Rad51 filament formation by repetitive motion on DNA. Nature Communications. 4: 2281. PMID 23939144 DOI: 10.1038/ncomms3281  1
2013 Lee KS, Balci H, Jia H, Lohman TM, Ha T. Direct imaging of single UvrD helicase dynamics on long single-stranded DNA. Nature Communications. 4: 1878. PMID 23695672 DOI: 10.1038/ncomms2882  1
2013 Xie F, Wu CG, Weiland E, Lohman TM. Asymmetric regulation of bipolar single-stranded DNA translocation by the two motors within Escherichia coli RecBCD helicase. The Journal of Biological Chemistry. 288: 1055-64. PMID 23192341 DOI: 10.1074/jbc.M112.423384  1
2012 Kozlov AG, Galletto R, Lohman TM. SSB-DNA binding monitored by fluorescence intensity and anisotropy. Methods in Molecular Biology (Clifton, N.J.). 922: 55-83. PMID 22976177 DOI: 10.1007/978-1-62703-032-8_4  1
2012 Kozlov AG, Lohman TM. SSB binding to ssDNA using isothermal titration calorimetry. Methods in Molecular Biology (Clifton, N.J.). 922: 37-54. PMID 22976176 DOI: 10.1007/978-1-62703-032-8_3  1
2012 Wu CG, Xie F, Lohman TM. The primary and secondary translocase activities within E. coli RecBC helicase are tightly coupled to ATP hydrolysis by the RecB motor. Journal of Molecular Biology. 423: 303-14. PMID 22820092 DOI: 10.1016/j.jmb.2012.07.009  1
2012 Fischer CJ, Tomko EJ, Wu CG, Lohman TM. Fluorescence methods to study DNA translocation and unwinding kinetics by nucleic acid motors. Methods in Molecular Biology (Clifton, N.J.). 875: 85-104. PMID 22573437 DOI: 10.1007/978-1-61779-806-1_5  1
2012 Antony E, Kozlov AG, Nguyen B, Lohman TM. Plasmodium falciparum SSB tetramer binds single-stranded DNA only in a fully wrapped mode. Journal of Molecular Biology. 420: 284-95. PMID 22543238 DOI: 10.1016/j.jmb.2012.04.022  1
2012 Antony E, Weiland EA, Korolev S, Lohman TM. Plasmodium falciparum SSB tetramer wraps single-stranded DNA with similar topology but opposite polarity to E. coli SSB. Journal of Molecular Biology. 420: 269-83. PMID 22543099 DOI: 10.1016/j.jmb.2012.04.021  1
2012 Ha T, Kozlov AG, Lohman TM. Single-molecule views of protein movement on single-stranded DNA. Annual Review of Biophysics. 41: 295-319. PMID 22404684 DOI: 10.1146/annurev-biophys-042910-155351  1
2012 Tomko EJ, Fischer CJ, Lohman TM. Single-stranded DNA translocation of E. coli UvrD monomer is tightly coupled to ATP hydrolysis. Journal of Molecular Biology. 418: 32-46. PMID 22342931 DOI: 10.1016/j.jmb.2012.02.013  1
2011 Balci H, Arslan S, Myong S, Lohman TM, Ha T. Single-molecule nanopositioning: structural transitions of a helicase-DNA complex during ATP hydrolysis. Biophysical Journal. 101: 976-84. PMID 21843490 DOI: 10.1016/j.bpj.2011.07.010  1
2011 Niedziela-Majka A, Maluf NK, Antony E, Lohman TM. Self-assembly of Escherichia coli MutL and its complexes with DNA. Biochemistry. 50: 7868-80. PMID 21793594 DOI: 10.1021/bi200753b  1
2011 Zhou R, Kozlov AG, Roy R, Zhang J, Korolev S, Lohman TM, Ha T. SSB functions as a sliding platform that migrates on DNA via reptation. Cell. 146: 222-32. PMID 21784244 DOI: 10.1016/j.cell.2011.06.036  1
2011 Jia H, Korolev S, Niedziela-Majka A, Maluf NK, Gauss GH, Myong S, Ha T, Waksman G, Lohman TM. Rotations of the 2B sub-domain of E. coli UvrD helicase/translocase coupled to nucleotide and DNA binding. Journal of Molecular Biology. 411: 633-48. PMID 21704638 DOI: 10.1016/j.jmb.2011.06.019  1
2011 Kozlov AG, Lohman TM. E. coli SSB tetramer binds the first and second molecules of (dT)(35) with heat capacities of opposite sign. Biophysical Chemistry. 159: 48-57. PMID 21636209 DOI: 10.1016/j.bpc.2011.05.005  1
2010 Tomko EJ, Jia H, Park J, Maluf NK, Ha T, Lohman TM. 5'-Single-stranded/duplex DNA junctions are loading sites for E. coli UvrD translocase. The Embo Journal. 29: 3826-39. PMID 20877334 DOI: 10.1038/emboj.2010.242  1
2010 Wu CG, Bradford C, Lohman TM. Escherichia coli RecBC helicase has two translocase activities controlled by a single ATPase motor. Nature Structural & Molecular Biology. 17: 1210-7. PMID 20852646 DOI: 10.1038/nsmb.1901  1
2010 Park J, Myong S, Niedziela-Majka A, Lee KS, Yu J, Lohman TM, Ha T. PcrA helicase dismantles RecA filaments by reeling in DNA in uniform steps. Cell. 142: 544-55. PMID 20723756 DOI: 10.1016/j.cell.2010.07.016  1
2010 Lohman TM. Clipping along. Journal of Molecular Biology. 399: 663-4. PMID 20447403 DOI: 10.1016/j.jmb.2010.04.063  1
2010 Tomko EJ, Fischer CJ, Lohman TM. Ensemble methods for monitoring enzyme translocation along single stranded nucleic acids. Methods (San Diego, Calif.). 51: 269-76. PMID 20371288 DOI: 10.1016/j.ymeth.2010.03.010  1
2010 Kozlov AG, Jezewska MJ, Bujalowski W, Lohman TM. Binding specificity of Escherichia coli single-stranded DNA binding protein for the chi subunit of DNA pol III holoenzyme and PriA helicase. Biochemistry. 49: 3555-66. PMID 20329707 DOI: 10.1021/bi100069s  1
2010 Fischer CJ, Wooten L, Tomko EJ, Lohman TM. Kinetics of motor protein translocation on single-stranded DNA. Methods in Molecular Biology (Clifton, N.J.). 587: 45-56. PMID 20225141 DOI: 10.1007/978-1-60327-355-8_4  1
2009 Roy R, Kozlov AG, Lohman TM, Ha T. SSB protein diffusion on single-stranded DNA stimulates RecA filament formation. Nature. 461: 1092-7. PMID 19820696 DOI: 10.1038/nature08442  1
2009 Antony E, Tomko EJ, Xiao Q, Krejci L, Lohman TM, Ellenberger T. Srs2 disassembles Rad51 filaments by a protein-protein interaction triggering ATP turnover and dissociation of Rad51 from DNA. Molecular Cell. 35: 105-15. PMID 19595720 DOI: 10.1016/j.molcel.2009.05.026  1
2008 Wu CG, Lohman TM. Influence of DNA end structure on the mechanism of initiation of DNA unwinding by the Escherichia coli RecBCD and RecBC helicases. Journal of Molecular Biology. 382: 312-26. PMID 18656489 DOI: 10.1016/j.jmb.2008.07.012  1
2008 Lohman TM, Tomko EJ, Wu CG. Non-hexameric DNA helicases and translocases: mechanisms and regulation. Nature Reviews. Molecular Cell Biology. 9: 391-401. PMID 18414490 DOI: 10.1038/nrm2394  1
2008 Wong CJ, Lohman TM. Kinetic control of Mg2+-dependent melting of duplex DNA ends by Escherichia coli RecBC. Journal of Molecular Biology. 378: 761-77. PMID 18395743 DOI: 10.1016/j.jmb.2008.03.023  1
2007 Niedziela-Majka A, Chesnik MA, Tomko EJ, Lohman TM. Bacillus stearothermophilus PcrA monomer is a single-stranded DNA translocase but not a processive helicase in vitro. The Journal of Biological Chemistry. 282: 27076-85. PMID 17631491 DOI: 10.1074/jbc.M704399200  1
2007 Tomko EJ, Fischer CJ, Niedziela-Majka A, Lohman TM. A nonuniform stepping mechanism for E. coli UvrD monomer translocation along single-stranded DNA. Molecular Cell. 26: 335-47. PMID 17499041 DOI: 10.1016/j.molcel.2007.03.024  1
2007 Roy R, Kozlov AG, Lohman TM, Ha T. Dynamic structural rearrangements between DNA binding modes of E. coli SSB protein. Journal of Molecular Biology. 369: 1244-57. PMID 17490681 DOI: 10.1016/j.jmb.2007.03.079  1
2006 Kumaran S, Kozlov AG, Lohman TM. Saccharomyces cerevisiae replication protein A binds to single-stranded DNA in multiple salt-dependent modes. Biochemistry. 45: 11958-73. PMID 17002295 DOI: 10.1021/bi060994r  1
2006 Wong CJ, Rice RL, Baker NA, Ju T, Lohman TM. Probing 3'-ssDNA loop formation in E. coli RecBCD/RecBC-DNA complexes using non-natural DNA: a model for "Chi" recognition complexes. Journal of Molecular Biology. 362: 26-43. PMID 16901504 DOI: 10.1016/j.jmb.2006.07.016  1
2006 Kuznetsov SV, Kozlov AG, Lohman TM, Ansari A. Microsecond dynamics of protein-DNA interactions: direct observation of the wrapping/unwrapping kinetics of single-stranded DNA around the E. coli SSB tetramer. Journal of Molecular Biology. 359: 55-65. PMID 16677671 DOI: 10.1016/j.jmb.2006.02.070  1
2006 Kozlov AG, Lohman TM. Effects of monovalent anions on a temperature-dependent heat capacity change for Escherichia coli SSB tetramer binding to single-stranded DNA. Biochemistry. 45: 5190-205. PMID 16618108 DOI: 10.1021/bi052543x  1
2005 Myong S, Rasnik I, Joo C, Lohman TM, Ha T. Repetitive shuttling of a motor protein on DNA. Nature. 437: 1321-5. PMID 16251956 DOI: 10.1038/nature04049  1
2005 Wong CJ, Lucius AL, Lohman TM. Energetics of DNA end binding by E.coli RecBC and RecBCD helicases indicate loop formation in the 3'-single-stranded DNA tail. Journal of Molecular Biology. 352: 765-82. PMID 16126227 DOI: 10.1016/j.jmb.2005.07.056  1
2005 Brendza KM, Cheng W, Fischer CJ, Chesnik MA, Niedziela-Majka A, Lohman TM. Autoinhibition of Escherichia coli Rep monomer helicase activity by its 2B subdomain. Proceedings of the National Academy of Sciences of the United States of America. 102: 10076-81. PMID 16009938 DOI: 10.1073/pnas.0502886102  1
2004 Fischer CJ, Maluf NK, Lohman TM. Mechanism of ATP-dependent translocation of E.coli UvrD monomers along single-stranded DNA. Journal of Molecular Biology. 344: 1287-309. PMID 15561144 DOI: 10.1016/j.jmb.2004.10.005  1
2004 Fischer CJ, Lohman TM. ATP-dependent translocation of proteins along single-stranded DNA: models and methods of analysis of pre-steady state kinetics. Journal of Molecular Biology. 344: 1265-86. PMID 15561143 DOI: 10.1016/j.jmb.2004.10.004  1
2004 Savvides SN, Raghunathan S, Fütterer K, Kozlov AG, Lohman TM, Waksman G. The C-terminal domain of full-length E. coli SSB is disordered even when bound to DNA. Protein Science : a Publication of the Protein Society. 13: 1942-7. PMID 15169953 DOI: 10.1110/ps.04661904  1
2004 Lucius AL, Lohman TM. Effects of temperature and ATP on the kinetic mechanism and kinetic step-size for E.coli RecBCD helicase-catalyzed DNA unwinding. Journal of Molecular Biology. 339: 751-71. PMID 15165848 DOI: 10.1016/j.jmb.2004.04.010  1
2004 Lucius AL, Wong CJ, Lohman TM. Fluorescence stopped-flow studies of single turnover kinetics of E.coli RecBCD helicase-catalyzed DNA unwinding. Journal of Molecular Biology. 339: 731-50. PMID 15165847 DOI: 10.1016/j.jmb.2004.04.009  1
2004 Murphy MC, Rasnik I, Cheng W, Lohman TM, Ha T. Probing single-stranded DNA conformational flexibility using fluorescence spectroscopy. Biophysical Journal. 86: 2530-7. PMID 15041689 DOI: 10.1016/S0006-3495(04)74308-8  1
2004 Rasnik I, Myong S, Cheng W, Lohman TM, Ha T. DNA-binding orientation and domain conformation of the E. coli rep helicase monomer bound to a partial duplex junction: single-molecule studies of fluorescently labeled enzymes. Journal of Molecular Biology. 336: 395-408. PMID 14757053 DOI: 10.1016/j.jmb.2003.12.031  1
2003 Lucius AL, Maluf NK, Fischer CJ, Lohman TM. General methods for analysis of sequential "n-step" kinetic mechanisms: application to single turnover kinetics of helicase-catalyzed DNA unwinding. Biophysical Journal. 85: 2224-39. PMID 14507688 DOI: 10.1016/S0006-3495(03)74648-7  1
2003 Maluf NK, Ali JA, Lohman TM. Kinetic mechanism for formation of the active, dimeric UvrD helicase-DNA complex. The Journal of Biological Chemistry. 278: 31930-40. PMID 12788954 DOI: 10.1074/jbc.M304223200  1
2003 Maluf NK, Fischer CJ, Lohman TM. A Dimer of Escherichia coli UvrD is the active form of the helicase in vitro. Journal of Molecular Biology. 325: 913-35. PMID 12527299 DOI: 10.1016/S0022-2836(02)01277-9  1
2003 Maluf NK, Lohman TM. Self-association equilibria of Escherichia coli UvrD helicase studied by analytical ultracentrifugation. Journal of Molecular Biology. 325: 889-912. PMID 12527298 DOI: 10.1016/S0022-2836(02)01276-7  1
2003 Lohman TM, Hsieh J, Maluf NK, Cheng W, Lucius AL, Fischer CJ, Brendza KM, Korolev S, Waksman G. DNA helicases, motors that move along nucleic acids: Lessons from the SF1 helicase superfamily Enzymes. 23: 303-369,III-VII. DOI: 10.1016/S1874-6047(04)80008-8  1
2002 Lucius AL, Vindigni A, Gregorian R, Ali JA, Taylor AF, Smith GR, Lohman TM. DNA unwinding step-size of E. coli RecBCD helicase determined from single turnover chemical quenched-flow kinetic studies. Journal of Molecular Biology. 324: 409-28. PMID 12445778  1
2002 Cheng W, Brendza KM, Gauss GH, Korolev S, Waksman G, Lohman TM. The 2B domain of the Escherichia coli Rep protein is not required for DNA helicase activity. Proceedings of the National Academy of Sciences of the United States of America. 99: 16006-11. PMID 12441398 DOI: 10.1073/pnas.242479399  1
2002 Ha T, Rasnik I, Cheng W, Babcock HP, Gauss GH, Lohman TM, Chu S. Initiation and re-initiation of DNA unwinding by the Escherichia coli Rep helicase. Nature. 419: 638-41. PMID 12374984 DOI: 10.1038/nature01083  1
2002 Kozlov AG, Lohman TM. Kinetic mechanism of direct transfer of Escherichia coli SSB tetramers between single-stranded DNA molecules. Biochemistry. 41: 11611-27. PMID 12269804 DOI: 10.1021/bi020361m  1
2002 Kozlov AG, Lohman TM. Stopped-flow studies of the kinetics of single-stranded DNA binding and wrapping around the Escherichia coli SSB tetramer. Biochemistry. 41: 6032-44. PMID 11993998 DOI: 10.1021/bi020122z  1
2001 Cheng W, Hsieh J, Brendza KM, Lohman TM. E. coli Rep oligomers are required to initiate DNA unwinding in vitro. Journal of Molecular Biology. 310: 327-50. PMID 11428893 DOI: 10.1006/jmbi.2001.4758  1
2000 Courtenay ES, Capp MW, Saecker RM, Record MT. Thermodynamic analysis of interactions between denaturants and protein surface exposed on unfolding: interpretation of urea and guanidinium chloride m-values and their correlation with changes in accessible surface area (ASA) using preferential interaction coefficients and the local-bulk domain model. Proteins. 72-85. PMID 11013402 DOI: 10.1002/1097-0134(2000)41:4+<72::AID-PROT70>3.0.CO;2-7  1
2000 Kozlov AG, Lohman TM. Large contributions of coupled protonation equilibria to the observed enthalpy and heat capacity changes for ssDNA binding to Escherichia coli SSB protein. Proteins. 8-22. PMID 11013397 DOI: 10.1002/1097-0134(2000)41:4+<8::AID-PROT20>3.0.CO;2-H  1
2000 Raghunathan S, Kozlov AG, Lohman TM, Waksman G. Structure of the DNA binding domain of E. coli SSB bound to ssDNA. Nature Structural Biology. 7: 648-52. PMID 10932248 DOI: 10.1038/77943  1
2000 Ha T, Babcock HP, Cheng W, Lohman TM, Chu S. Single molecule fluorescence study of DNA helicase activity Pacific Rim Conference On Lasers and Electro-Optics, Cleo - Technical Digest. 589-590.  1
1999 Ali JA, Maluf NK, Lohman TM. An oligomeric form of E. coli UvrD is required for optimal helicase activity. Journal of Molecular Biology. 293: 815-34. PMID 10543970 DOI: 10.1006/jmbi.1999.3185  1
1999 Kozlov AG, Lohman TM. Adenine base unstacking dominates the observed enthalpy and heat capacity changes for the Escherichia coli SSB tetramer binding to single-stranded oligoadenylates. Biochemistry. 38: 7388-97. PMID 10353851 DOI: 10.1021/bi990309z  1
1999 Hsieh J, Moore KJ, Lohman TM. A two-site kinetic mechanism for ATP binding and hydrolysis by E. coli Rep helicase dimer bound to a single-stranded oligodeoxynucleotide. Journal of Molecular Biology. 288: 255-74. PMID 10329141 DOI: 10.1006/jmbi.1999.2666  1
1999 Zhang W, Ni H, Capp MW, Anderson CF, Lohman TM, Record MT. The importance of coulombic end effects: experimental characterization of the effects of oligonucleotide flanking charges on the strength and salt dependence of oligocation (L8+) binding to single-stranded DNA oligomers. Biophysical Journal. 76: 1008-17. PMID 9916032 DOI: 10.1016/S0006-3495(99)77265-6  1
1998 Kozlov AG, Lohman TM. Calorimetric studies of E. coli SSB protein-single-stranded DNA interactions. Effects of monovalent salts on binding enthalpy. Journal of Molecular Biology. 278: 999-1014. PMID 9600857 DOI: 10.1006/jmbi.1998.1738  1
1998 Lohman TM, Thorn K, Vale RD. Staying on track: common features of DNA helicases and microtubule motors. Cell. 93: 9-12. PMID 9546385 DOI: 10.1016/S0092-8674(00)81139-3  1
1998 Korolev S, Yao N, Lohman TM, Weber PC, Waksman G. Comparisons between the structures of HCV and Rep helicases reveal structural similarities between SF1 and SF2 super-families of helicases. Protein Science : a Publication of the Protein Society. 7: 605-10. PMID 9541392 DOI: 10.1002/pro.5560070309  1
1998 Bjornson KP, Hsieh J, Amaratunga M, Lohman TM. Kinetic mechanism for the sequential binding of two single-stranded oligodeoxynucleotides to the Escherichia coli Rep helicase dimer. Biochemistry. 37: 891-9. PMID 9454579 DOI: 10.1021/bi9719307  1
1997 Korolev S, Hsieh J, Gauss GH, Lohman TM, Waksman G. Major domain swiveling revealed by the crystal structures of complexes of E. coli Rep helicase bound to single-stranded DNA and ADP. Cell. 90: 635-47. PMID 9288744 DOI: 10.1016/S0092-8674(00)80525-5  1
1997 Raghunathan S, Ricard CS, Lohman TM, Waksman G. Crystal structure of the homo-tetrameric DNA binding domain of Escherichia coli single-stranded DNA-binding protein determined by multiwavelength x-ray diffraction on the selenomethionyl protein at 2.9-A resolution. Proceedings of the National Academy of Sciences of the United States of America. 94: 6652-7. PMID 9192620 DOI: 10.1073/pnas.94.13.6652  1
1997 Mascotti DP, Lohman TM. Thermodynamics of oligoarginines binding to RNA and DNA. Biochemistry. 36: 7272-9. PMID 9188729 DOI: 10.1021/bi970272n  1
1997 Ferrari ME, Fang J, Lohman TM. A mutation in E. coli SSB protein (W54S) alters intra-tetramer negative cooperativity and inter-tetramer positive cooperativity for single-stranded DNA binding. Biophysical Chemistry. 64: 235-51. PMID 9127948 DOI: 10.1016/S0301-4622(96)02223-5  1
1997 Wong I, Lohman TM. A two-site mechanism for ATP hydrolysis by the asymmetric Rep dimer P2S as revealed by site-specific inhibition with ADP-A1F4. Biochemistry. 36: 3115-25. PMID 9115987 DOI: 10.1021/bi9621977  1
1997 Ali JA, Lohman TM. Kinetic measurement of the step size of DNA unwinding by Escherichia coli UvrD helicase. Science (New York, N.Y.). 275: 377-80. PMID 8994032 DOI: 10.1126/science.275.5298.377  1
1996 Bjornson KP, Wong I, Lohman TM. ATP hydrolysis stimulates binding and release of single stranded DNA from alternating subunits of the dimeric E. coli Rep helicase: implications for ATP-driven helicase translocation. Journal of Molecular Biology. 263: 411-22. PMID 8918597 DOI: 10.1006/jmbi.1996.0585  1
1996 Wong I, Lohman TM. ATPase activity of Escherichia coli Rep helicase crosslinked to single-stranded DNA: implications for ATP driven helicase translocation. Proceedings of the National Academy of Sciences of the United States of America. 93: 10051-6. PMID 8816749  1
1996 Lohman TM, Bjornson KP. Mechanisms of helicase-catalyzed DNA unwinding. Annual Review of Biochemistry. 65: 169-214. PMID 8811178 DOI: 10.1146/annurev.bi.65.070196.001125  1
1996 Bjornson KP, Moore KJ, Lohman TM. Kinetic mechanism of DNA binding and DNA-induced dimerization of the Escherichia coli Rep helicase. Biochemistry. 35: 2268-82. PMID 8652567 DOI: 10.1021/bi9522763  1
1996 Wong I, Moore KJ, Bjornson KP, Hsieh J, Lohman TM. ATPase activity of Escherichia coli Rep helicase is dramatically dependent on DNA ligation and protein oligomeric states. Biochemistry. 35: 5726-34. PMID 8639532 DOI: 10.1021/bi952959i  1
1996 Zhang W, Bond JP, Anderson CF, Lohman TM, Record MT. Large electrostatic differences in the binding thermodynamics of a cationic peptide to oligomeric and polymeric DNA. Proceedings of the National Academy of Sciences of the United States of America. 93: 2511-6. PMID 8637905 DOI: 10.1073/pnas.93.6.2511  1
1996 Lohman TM, Overman LB, Ferrari ME, Kozlov AG. A highly salt-dependent enthalpy change for Escherichia coli SSB protein-nucleic acid binding due to ion-protein interactions. Biochemistry. 35: 5272-9. PMID 8611514 DOI: 10.1021/bi9527606  1
1995 Wong I, Lohman TM. Linkage of protein assembly to protein-DNA binding. Methods in Enzymology. 259: 95-127. PMID 8538477 DOI: 10.1016/0076-6879(95)59040-4  1
1995 Mascotti DP, Lohman TM. Thermodynamics of charged oligopeptide-heparin interactions. Biochemistry. 34: 2908-15. PMID 7893705  1
1995 Moore KJ, Lohman TM. Helicase-catalyzed DNA unwinding: energy coupling by DNA motor proteins. Biophysical Journal. 68: 180S-184S; discussio. PMID 7787063  1
1994 Lohman TM, Bujalowski W. Effects of base composition on the negative cooperativity and binding mode transitions of Escherichia coli SSB-single-stranded DNA complexes. Biochemistry. 33: 6167-76. PMID 8193130  1
1994 Overman LB, Lohman TM. Linkage of pH, anion and cation effects in protein-nucleic acid equilibria. Escherichia coli SSB protein-single stranded nucleic acid interactions. Journal of Molecular Biology. 236: 165-78. PMID 8107102 DOI: 10.1006/jmbi.1994.1126  1
1994 Ferrari ME, Bujalowski W, Lohman TM. Co-operative binding of Escherichia coli SSB tetramers to single-stranded DNA in the (SSB)35 binding mode. Journal of Molecular Biology. 236: 106-23. PMID 8107097 DOI: 10.1006/jmbi.1994.1122  1
1994 Moore KJ, Lohman TM. Kinetic mechanism of adenine nucleotide binding to and hydrolysis by the Escherichia coli Rep monomer. 2. Application of a kinetic competition approach. Biochemistry. 33: 14565-78. PMID 7981218  1
1994 Moore KJ, Lohman TM. Kinetic mechanism of adenine nucleotide binding to and hydrolysis by the Escherichia coli Rep monomer. 1. Use of fluorescent nucleotide analogues. Biochemistry. 33: 14550-64. PMID 7981217 DOI: 10.1021/bi00252a023  1
1994 Lohman TM, Ferrari ME. Escherichia coli single-stranded DNA-binding protein: multiple DNA-binding modes and cooperativities. Annual Review of Biochemistry. 63: 527-70. PMID 7979247 DOI: 10.1146/annurev.bi.63.070194.002523  1
1994 Bjornson KP, Amaratunga M, Moore KJ, Lohman TM. Single-turnover kinetics of helicase-catalyzed DNA unwinding monitored continuously by fluorescence energy transfer. Biochemistry. 33: 14306-16. PMID 7947840 DOI: 10.1021/bi00251a044  1
1994 Ferrari ME, Lohman TM. Apparent heat capacity change accompanying a nonspecific protein-DNA interaction. Escherichia coli SSB tetramer binding to oligodeoxyadenylates. Biochemistry. 33: 12896-910. PMID 7947696  1
1993 Wong I, Lohman TM. A double-filter method for nitrocellulose-filter binding: application to protein-nucleic acid interactions. Proceedings of the National Academy of Sciences of the United States of America. 90: 5428-32. PMID 8516284  1
1993 Amaratunga M, Lohman TM. Escherichia coli rep helicase unwinds DNA by an active mechanism. Biochemistry. 32: 6815-20. PMID 8392863  1
1993 Lohman TM. Helicase-catalyzed DNA unwinding. The Journal of Biological Chemistry. 268: 2269-72. PMID 8381400  1
1993 Runyon GT, Wong I, Lohman TM. Overexpression, purification, DNA binding, and dimerization of the Escherichia coli uvrD gene product (helicase II). Biochemistry. 32: 602-12. PMID 8380701 DOI: 10.1021/bi00053a028  1
1993 Wong I, Amaratunga M, Lohman TM. Heterodimer formation between Escherichia coli Rep and UvrD proteins. The Journal of Biological Chemistry. 268: 20386-91. PMID 8376396  1
1993 Mascotti DP, Lohman TM. Thermodynamics of single-stranded RNA and DNA interactions with oligolysines containing tryptophan. Effects of base composition. Biochemistry. 32: 10568-79. PMID 7691177  1
1992 Wei TF, Bujalowski W, Lohman TM. Cooperative binding of polyamines induces the Escherichia coli single-strand binding protein-DNA binding mode transitions. Biochemistry. 31: 6166-74. PMID 1627560  1
1992 Wong I, Lohman TM. Allosteric effects of nucleotide cofactors on Escherichia coli Rep helicase-DNA binding. Science (New York, N.Y.). 256: 350-5. PMID 1533057  1
1992 Lohman TM, Mascotti DP. Nonspecific ligand-DNA equilibrium binding parameters determined by fluorescence methods. Methods in Enzymology. 212: 424-58. PMID 1518458 DOI: 10.1016/0076-6879(92)12027-N  1
1992 Lohman TM, Mascotti DP. Thermodynamics of ligand-nucleic acid interactions. Methods in Enzymology. 212: 400-24. PMID 1518457 DOI: 10.1016/0076-6879(92)12026-M  1
1992 Mascotti DP, Lohman TM. Thermodynamics of single-stranded RNA binding to oligolysines containing tryptophan. Biochemistry. 31: 8932-46. PMID 1382582  1
1992 Wong I, Chao KL, Bujalowski W, Lohman TM. DNA-induced dimerization of the Escherichia coli rep helicase. Allosteric effects of single-stranded and duplex DNA. The Journal of Biological Chemistry. 267: 7596-610. PMID 1313807  1
1992 Lohman TM. Escherichia coli DNA helicases: mechanisms of DNA unwinding. Molecular Microbiology. 6: 5-14. PMID 1310794  1
1991 Bujalowski W, Lohman TM. Monomers of the Escherichia coli SSB-1 mutant protein bind single-stranded DNA. Journal of Molecular Biology. 217: 63-74. PMID 1988680 DOI: 10.1016/0022-2836(91)90611-9  1
1991 Bujalowski W, Lohman TM. Monomer-tetramer equilibrium of the Escherichia coli ssb-1 mutant single strand binding protein. The Journal of Biological Chemistry. 266: 1616-26. PMID 1988441  1
1991 Lohman TM, Bujalowski W. Thermodynamic methods for model-independent determination of equilibrium binding isotherms for protein-DNA interactions: spectroscopic approaches to monitor binding. Methods in Enzymology. 208: 258-90. PMID 1779838  1
1991 Chao KL, Lohman TM. DNA-induced dimerization of the Escherichia coli Rep helicase. Journal of Molecular Biology. 221: 1165-81. PMID 1658335 DOI: 10.1016/0022-2836(91)90926-W  1
1990 Mascotti DP, Lohman TM. Thermodynamic extent of counterion release upon binding oligolysines to single-stranded nucleic acids. Proceedings of the National Academy of Sciences of the United States of America. 87: 3142-6. PMID 2326273  1
1990 Runyon GT, Bear DG, Lohman TM. Escherichia coli helicase II (UvrD) protein initiates DNA unwinding at nicks and blunt ends. Proceedings of the National Academy of Sciences of the United States of America. 87: 6383-7. PMID 2166955 DOI: 10.1073/pnas.87.16.6383  1
1990 Chao K, Lohman TM. DNA and nucleotide-induced conformational changes in the Escherichia coli Rep and helicase II (UvrD) proteins. The Journal of Biological Chemistry. 265: 1067-76. PMID 2153101  1
1989 Bujalowski W, Lohman TM, Anderson CF. On the cooperative binding of large ligands to a one-dimensional homogeneous lattice: the generalized three-state lattice model. Biopolymers. 28: 1637-43. PMID 2775853 DOI: 10.1002/bip.360280912  1
1989 Bujalowski W, Lohman TM. Negative co-operativity in Escherichia coli single strand binding protein-oligonucleotide interactions. II. Salt, temperature and oligonucleotide length effects Journal of Molecular Biology. 207: 269-288. PMID 2661833 DOI: 10.1016/0022-2836(89)90455-5  1
1989 Bujalowski W, Lohman TM. Negative co-operativity in Escherichia coli single strand binding protein-oligonucleotide interactions. I. Evidence and a quantitative model Journal of Molecular Biology. 207: 249-268. PMID 2661832 DOI: 10.1016/0022-2836(89)90454-3  1
1989 Runyon GT, Lohman TM. Escherichia coli helicase II (uvrD) protein can completely unwind fully duplex linear and nicked circular DNA. The Journal of Biological Chemistry. 264: 17502-12. PMID 2529260  1
1989 Lohman TM, Chao K, Green JM, Sage S, Runyon GT. Large-scale purification and characterization of the Escherichia coli rep gene product. The Journal of Biological Chemistry. 264: 10139-47. PMID 2524489  1
1989 Jezewska MJ, Bujalowski W, Lohman TM. Iron(II)-ethylenediaminetetraacetic acid catalyzed cleavage of DNA is highly specific for duplex DNA. Biochemistry. 28: 6161-4. PMID 2506924  1
1988 Lohman TM, Bujalowski W. Negative cooperativity within individual tetramers of Escherichia coli single strand binding protein is responsible for the transition between the (SSB)35 and (SSB)56 DNA binding modes Biochemistry®. 27: 2260-2265. PMID 3289611  1
1988 Lohman TM, Bujalowski W, Overman LB, Wei TF. Interactions of the E. coli Single Strand Binding (SSB) protein with ss nucleic acids. Binding mode transitions and equilibrium binding studies Biochemical Pharmacology. 37: 1781-1782. PMID 3288214  1
1988 Bujalowski W, Overman LB, Lohman TM. Binding mode transitions of Escherichia coli single strand binding protein-single-stranded DNA complexes Journal of Biological Chemistry. 263: 4629-4640. PMID 3280566  1
1988 Overman LB, Bujalowski W, Lohman TM. Equilibrium binding of Escherichia coli single-strand binding protein to single-stranded nucleic acids in the (SSB)65 binding mode. Cation and anion effects and polynucleotide specificity Biochemistry. 27: 456-471. PMID 3280021  1
1988 Lohman TM, Bujalowski W, Overman LB. E. coli single strand binding protein: a new look at helix-destabilizing proteins Trends in Biochemical Sciences. 13: 250-255. PMID 2855682  1
1987 Bujalowski W, Lohman TM. Limited co-operativity in protein-nucleic acid interactions. A thermodynamic model for the interactions of Escherichia coli single strand binding protein with single-stranded nucleic acids in the "beaded", (SSB)65 mode Journal of Molecular Biology. 195: 897-907. PMID 3309344 DOI: 10.1016/0022-2836(87)90493-1  1
1986 Bujalowski W, Lohman TM. Escherichia coli single-strand binding protein forms multiple, distinct complexes with single-stranded DNA Biochemistry. 25: 7799-7802. PMID 3542037  1
1986 Lohman TM, Overman LB, Datta S. Salt-dependent changes in the DNA binding co-operativity of Escherichia coli single strand binding protein Journal of Molecular Biology. 187: 603-615. PMID 3519979 DOI: 10.1016/0022-2836(86)90338-4  1
1986 Lohman TM. Kinetics of protein-nucleic acid interactions: use of salt effects to probe mechanisms of interaction Crc Critical Reviews in Biochemistry. 19: 191-245. PMID 3512164  1
1986 Lohman TM, Michael Green J, Beyer RS. Large-scale overproduction and rapid purification of the Escherichia coli ssb gene product. Expression of the ssb gene under λ PL control Biochemistry. 25: 21-25. PMID 3006753  1
1985 Lohman TM, Overman LB. Two binding modes in Escherichia coli single strand binding protein-single stranded DNA complexes. Modulation by NaCl concentration Journal of Biological Chemistry. 260: 3594-3603. PMID 3882711  1
1984 Lohman TM. Kinetics and mechanism of dissociation of cooperatively bound T4 gene 32 protein-single-stranded nucleic acid complexes. 2. Changes in mechanism as a function of sodium chloride concentration and other solution variables Biochemistry. 23: 4665-4675. PMID 6388632  1
1984 Lohman TM. Kinetics and mechanism of dissociation of cooperatively bound T4 gene 32 protein-single-stranded nucleic acid complexes. 1. Irreversible dissociation induced by sodium chloride concentration jumps Biochemistry. 23: 4656-4665. PMID 6388631  1
1983 Lohman TM. Model for the irreversible dissociation kinetics of cooperatively bound protein-nucleic acid complexes Biopolymers - Peptide Science Section. 22: 1697-1713. PMID 6882871  1
1981 Lohman TM, Kowalczykowski SC. Kinetics and mechanism of the association of the bacteriophage T4 gene 32 (helix destabilizing) protein with single-stranded nucleic acids. Evidence for protein translocation Journal of Molecular Biology. 152: 67-109. PMID 6279865 DOI: 10.1016/0022-2836(81)90096-6  1
1980 Lohman TM, DeHaseth PL, Record MT. Pentalysine-deoxyribonucleic acid interactions: A model for the general effects of ion concentrations on the interactions of proteins with nucleic acids Biochemistry. 19: 3522-3530. PMID 7407056  1
1980 Lohman TM, Wensley CG, Cina J, Burgess RR, Record MT. Use of difference boundary sedimentation velocity to investigate nonspecific protein-nucleic acid interactions Biochemistry. 19: 3516-3522. PMID 6250571  1
1978 Lohman TM, DeHaseth PL, Record MT. Analysis of ion concentration effects on the kinetics of protein-nucleic acid interactions. Application to lac repressor-operator interactions Biophysical Chemistry. 8: 281-294. PMID 728535 DOI: 10.1016/0301-4622(78)80011-8  1
1978 Record MT, Anderson CF, Lohman TM. Thermodynamic analysis of ion effects on the binding and conformational equilibria of proteins and nucleic acids: the roles of ion association or release, screening, and ion effects on water activity Quarterly Reviews of Biophysics. 11: 103-178. PMID 353875  1
1978 DeHaseth PL, Lohman TM, Burgess RR, Record MT. Nonspecific interactions of Escherichia coli RNA polymerase with native and denatured DNA: Differences in the binding behavior of core and holoenzyme Biochemistry. 17: 1612-1622. PMID 350271  1
1978 Record MT, Lohman TM. A semiempirical extension of polyelectrolyte theory to the treatment of oligoelectrolytes: application to oligonucleotide helix-coil transitions Biopolymers. 17: 159-166.  1
1977 Record MT, DeHaseth PL, Lohman TM. Interpretation of monovalent and divalent cation effects on the lac repressor-operator interaction Biochemistry. 16: 4791-4796. PMID 911790  1
1977 DeHaseth PL, Lohman TM, Record MT. Nonspecific interaction of lac repressor with DNA: An association reaction driven by counterion release Biochemistry. 16: 4783-4790. PMID 911789  1
1976 Record MT, Lohman TM, Haseth Pd. Ion effects on ligand-nucleic acid interactions Journal of Molecular Biology. 107: 145-158. PMID 1003464 DOI: 10.1016/S0022-2836(76)80023-X  1
1976 Record MT, Woodbury CP, Lohman TM. Na+ effects on transitions of DNA and polynucleotides of variable linear charge density Biopolymers. 15: 893-915. PMID 4169  1
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