Sankar K. Guchhait - Publications

Affiliations: 
2007- National Institute of Pharmaceutical Education and Research, Mohali 
Area:
Synthetic organic chemistry, natural products chemistry, medicinal chemistry, anticancer drugs
Website:
https://www.skguchhait.com/home

68 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Saini M, Paul S, Acharya A, Acharya SS, Kundu CN, Guchhait SK. Scaffold overlay of flavonoid-inspired molecules: Discovery of 2,3-diaryl-pyridopyrimidin-4-imine/ones as dual hTopo-II and tubulin targeting anticancer agents. Bioorganic Chemistry. 152: 107738. PMID 39182257 DOI: 10.1016/j.bioorg.2024.107738  0.8
2024 Yadav M, Roy N, Mandal K, Nagpure M, Santra MK, Guchhait SK. Rutaecarpine-inspired scaffold-hopping strategy and Ullmann cross-coupling based synthetic approach: Identification of pyridopyrimidinone-indole based novel anticancer chemotypes. Bioorganic & Medicinal Chemistry. 109: 117799. PMID 38897138 DOI: 10.1016/j.bmc.2024.117799  0.375
2024 Krishna Rao V, Paul S, Gulkis M, Shen Z, Nair H, Singh A, Li C, Sharma AK, Çağlayan M, Das C, Das B, Kundu CN, Narayan S, Guchhait SK. Molecular editing of enabling discovery of benzodithiazinedioxide-guanidines as anticancer agents. Rsc Medicinal Chemistry. 15: 937-962. PMID 38516586 DOI: 10.1039/d3md00648d  0.329
2023 Acharya A, Yadav M, Nagpure M, Kumarsan S, Guchhait SK. Molecular medicinal insights into scaffold hopping-based drug discovery success. Drug Discovery Today. 103845. PMID 38013043 DOI: 10.1016/j.drudis.2023.103845  0.772
2023 Rao VK, Ashtam A, Panda D, Guchhait SK. Natural product-inspired discovery of trimethoxyphenyl-1,2,4-triazolo-sulfonamides as potent tubulin polymerization inhibitors. Chemmedchem. e202300562. PMID 37975190 DOI: 10.1002/cmdc.202300562  0.38
2023 Giri P, Batra PJ, Kumari A, Hura N, Adhikary R, Acharya A, Guchhait SK, Panda D. Development of QTMP: A promising anticancer agent through NP-Privileged Motif-Driven structural modulation. Bioorganic & Medicinal Chemistry. 95: 117489. PMID 37816266 DOI: 10.1016/j.bmc.2023.117489  0.808
2022 Sisodiya S, Acharya A, Nagpure M, Roy N, Giri SK, Yadav HR, R Choudhury A, Guchhait SK. A cascade reaction of indolyl-migratory isocyanide insertion, scaffold rearrangement and redox-neutral event with isocyanide as a CH-N synthon efficiently constructs indolylisoindolinones. Chemical Communications (Cambridge, England). 58: 11827-11830. PMID 36190521 DOI: 10.1039/d2cc04273h  0.758
2022 Shah AP, Hura N, Babu NK, Roy N, Rao VK, Paul A, Roy PK, Singh S, Guchhait SK. A "Core-Linker-Polyamine (CLP)" strategy enabling rapid discovery of antileishmanial aminoalkyl-quinoline-carboxamides that target oxidative stress mechanism. Chemmedchem. PMID 35638162 DOI: 10.1002/cmdc.202200109  0.81
2022 Kumar G, Das C, Acharya A, Bhal S, Joshi M, Kundu CN, Choudhury AR, Guchhait SK. Organocatalyzed umpolung addition for synthesis of heterocyclic-fused arylidene-imidazolones as anticancer agents. Bioorganic & Medicinal Chemistry. 67: 116835. PMID 35617791 DOI: 10.1016/j.bmc.2022.116835  0.813
2022 Kumari A, Jaiswal T, Kumar V, Hura N, Kumar G, Babu NK, Acharya A, Roy PK, Guchhait SK, Singh S. Identification of 2-arylquinazolines with alkyl-polyamine motifs as potent antileishmanial agents: synthesis and biological evaluation studies. Rsc Medicinal Chemistry. 13: 320-326. PMID 35434631 DOI: 10.1039/d1md00336d  0.793
2021 Sisodiya S, Paul S, Chaudhary H, Grewal P, Kumar G, Daniel DP, Das B, Nayak D, Guchhait SK, Kundu CN, Banerjee UC. Exploration of Benzo[b]carbazole-6,11-diones as anticancer agents: Synthesis and studies of hTopoIIα inhibition and Apoptotic effects. Bioorganic & Medicinal Chemistry Letters. 128274. PMID 34303812 DOI: 10.1016/j.bmcl.2021.128274  0.811
2021 Guchhait SK, Saini M, Khivsara VJ, Giri SK. Annulation of Conjugated Azine-Imine with a Sulfoxonium Ylide in a Noncarbenoid Route to Synthesize Multisubstituted Imidazole-Fused Heterocycles. The Journal of Organic Chemistry. PMID 33759525 DOI: 10.1021/acs.joc.1c00052  0.805
2021 Kumari A, Shriwas O, Sisodiya S, Santra MK, Guchhait SK, Dash R, Panda D. Microtubule-targeting agents impair kinesin-2-dependent nuclear transport of β-catenin: Evidence of inhibition of Wnt/β-catenin signaling as an important antitumor mechanism of microtubule-targeting agents. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 35: e21539. PMID 33742719 DOI: 10.1096/fj.202002594R  0.573
2020 Guchhait SK, Saini M. Chan–Lam N-arylation and C–H amination with heteroaromatic ring-NH: an approach to access extended-fused imidazo[1,2-a]-pyridines/pyrazines New Journal of Chemistry. 44: 308-312. DOI: 10.1039/C9Nj04966E  0.493
2019 Kumari A, Srivastava S, Manne RK, Sisodiya S, Santra MK, Guchhait SK, Panda D. C12, a combretastatin-A4 analog, exerts anticancer activity by targeting microtubules. Biochemical Pharmacology. 113663. PMID 31606408 DOI: 10.1016/J.Bcp.2019.113663  0.668
2018 Hura N, Sawant AV, Kumari A, Guchhait SK, Panda D. Combretastatin-Inspired Heterocycles as Antitubulin Anticancer Agents. Acs Omega. 3: 9754-9769. PMID 31459105 DOI: 10.1021/acsomega.8b00996  0.797
2018 Tripathi N, Guchhait SK, Bharatam PV. Pharmacoinformatics analysis of merbarone binding site in human topoisomerase IIα. Journal of Molecular Graphics & Modelling. 86: 1-18. PMID 30296751 DOI: 10.1016/J.Jmgm.2018.09.013  0.758
2018 Hura N, Naaz A, Prassanawar SS, Guchhait SK, Panda D. Drug-Clinical Agent Molecular Hybrid: Synthesis of Diaryl(trifluoromethyl)pyrazoles as Tubulin Targeting Anticancer Agents. Acs Omega. 3: 1955-1969. PMID 30023819 DOI: 10.1021/acsomega.7b01784  0.826
2018 Guchhait SK, Sisodiya S, Saini M, Shah YV, Kumar G, Daniel DP, Hura N, Chaudhary V. Synthesis of polyfunctionalized pyrroles via a tandem reaction of Michael addition and intramolecular cyanide-mediated nitrile-to-nitrile condensation. The Journal of Organic Chemistry. PMID 29671317 DOI: 10.1021/Acs.Joc.8B00465  0.792
2018 Kumari A, Srivastava S, Shyam Prassanawar S, Sisodiya S, Guchhait SK, Panda D. A Combretastatin Analogue C12 Binds to Colchicine Site in Tubulin, Inhibits Spindle Microtubule Dynamics, Activates Mitotic Checkpoint and Induces Apoptosis in Cancer Cells Biophysical Journal. 114: 415a. DOI: 10.1016/J.Bpj.2017.11.2303  0.655
2017 Guchhait SK, Saini M, Sumkaria D, Chaudhary V. A nitrile-stabilized ammonium ylide as a masked C-C[double bond, length as m-dash]N synthon in heterocyclization with amidine-imine: 3-component assembly to fused pyrimidine scaffolds. Chemical Communications (Cambridge, England). 53: 6941-6944. PMID 28612882 DOI: 10.1039/C7Cc02946B  0.791
2017 Guchhait SK, Hura N, Shah AP. Synthesis of polysubstituted 2-aminoimidazoles via alkene-diamination of guanidine with conjugated α-bromoalkenones. The Journal of Organic Chemistry. PMID 28195472 DOI: 10.1021/Acs.Joc.6B03021  0.813
2017 Guchhait SK, Hura N, Sinha K, Panda D. Pyridine C3-arylation of nicotinic acids accessible via a multicomponent reaction: an entry to all-substituted-3,4-diarylated pyridines Rsc Advances. 7: 8323-8331. DOI: 10.1039/C6Ra28299G  0.511
2016 Priyadarshani G, Nayak A, Amrutkar SM, Das S, Guchhait SK, Kundu CN, Banerjee UC. Scaffold-Hopping of Aurones: 2-Arylideneimidazo[1,2-a]pyridinones as Topoisomerase IIα-Inhibiting Anticancer Agents. Acs Medicinal Chemistry Letters. 7: 1056-1061. PMID 27994737 DOI: 10.1021/Acsmedchemlett.6B00242  0.812
2016 Priyadarshani G, Amrutkar S, Nayak A, Banerjee UC, Kundu CN, Guchhait SK. Scaffold-hopping of bioactive flavonoids: Discovery of aryl-pyridopyrimidinones as potent anticancer agents that inhibit catalytic role of topoisomerase IIα. European Journal of Medicinal Chemistry. 122: 43-54. PMID 27343852 DOI: 10.1016/J.Ejmech.2016.06.024  0.822
2016 Nandekar PP, Khomane K, Chaudhary V, Rathod VP, Borkar RM, Bhandi MM, Srinivas R, Sangamwar AT, Guchhait SK, Bansal AK. Identification of leads for antiproliferative activity on MDA-MB-435 human breast cancer cells through pharmacophore and CYP1A1-mediated metabolism. European Journal of Medicinal Chemistry. 115: 82-93. PMID 26994845 DOI: 10.1016/J.Ejmech.2016.02.061  0.496
2016 Guchhait SK, Chaudhary V, Rana VA, Priyadarshani G, Kandekar S, Kashyap M. Oxidative Dearomatization of Indoles via Pd-Catalyzed C-H Oxygenation: An Entry to C2-Quaternary Indolin-3-ones. Organic Letters. 18: 1534-7. PMID 26986450 DOI: 10.1021/Acs.Orglett.6B00244  0.781
2016 Chaudhary V, Venghateri JB, Dhaked HP, Bhoyar AS, Guchhait SK, Panda D. Novel Combretastatin-2-aminoimidazole Analogues as Potent Tubulin Assembly Inhibitors: Exploration of Unique Pharmacophoric Impact of Bridging Skeleton and Aryl Moiety. Journal of Medicinal Chemistry. 59: 3439-51. PMID 26938120 DOI: 10.1021/Acs.Jmedchem.6B00101  0.514
2016 Guchhait SK, Priyadarshani G, Gulghane NM. A reaction of 1,2-diamines and aldehydes with silyl cyanide as cyanide pronucleophile to access 2-aminopyrazines and 2-aminoquinoxalines Rsc Advances. 6: 56056-56063. DOI: 10.1039/C6Ra12028H  0.501
2015 Guchhait SK, Priyadarshani G. Pd-Catalyzed Ag(I)-Promoted C3-Arylation of Pyrido[1,2-a]pyrimidin-4-ones with Bromo/Iodo-Arenes Journal of Organic Chemistry. 80: 8482-8488. PMID 26247916 DOI: 10.1021/Acs.Joc.5B01573  0.802
2015 Guchhait SK, Priyadarshani G. Synthesis of 2-Arylpyridopyrimidinones, 6-Aryluracils, and Tri- and Tetrasubstituted Conjugated Alkenes via Pd-Catalyzed Enolic C-O Bond Activation-Arylation Journal of Organic Chemistry. 80: 6342-6349. PMID 25996549 DOI: 10.1021/Acs.Joc.5B00771  0.82
2015 Baviskar AT, Amrutkar SM, Trivedi N, Chaudhary V, Nayak A, Guchhait SK, Banerjee UC, Bharatam PV, Kundu CN. Switch in Site of Inhibition: A Strategy for Structure-Based Discovery of Human Topoisomerase IIα Catalytic Inhibitors. Acs Medicinal Chemistry Letters. 6: 481-5. PMID 25941559 DOI: 10.1021/Acsmedchemlett.5B00040  0.786
2015 Chaudhary V, Das S, Nayak A, Guchhait SK, Kundu CN. Scaffold-hopping and hybridization based design and building block strategic synthesis of pyridine-annulated purines: Discovery of novel apoptotic anticancer agents Rsc Advances. 5: 26051-26060. DOI: 10.1039/C5Ra00052A  0.582
2014 Guchhait SK, Chaudhary V. Desilylative activation of TMSCN in chemoselective Strecker-Ugi type reaction: Functional fused imidazoles as building blocks as an entry route to annulated purines Organic and Biomolecular Chemistry. 12: 6694-6705. PMID 25032666 DOI: 10.1039/C4Ob00882K  0.544
2014 Guchhait SK, Priyadarshani G, Hura N. α,β-Epoxy esters in multiple C-O/C-N bond-breaking/formation with 2-aminopyridines; Synthesis of biologically relevant (Z)-2- methyleneimidazo[1,2- a ]pyridin-3-ones Synlett. 25: 1692-1696. DOI: 10.1055/S-0033-1339105  0.482
2014 Sanghai N, Jain V, Preet R, Kandekar S, Das S, Trivedi N, Mohapatra P, Priyadarshani G, Kashyap M, Das D, Satapathy SR, Siddharth S, Guchhait SK, Kundu CN, Bharatam PV. Combretastatin A-4 inspired novel 2-aryl-3-arylamino-imidazo-pyridines/ pyrazines as tubulin polymerization inhibitors, antimitotic and anticancer agents Medchemcomm. 5: 766-782. DOI: 10.1039/C3Md00357D  0.821
2013 Kandekar S, Preet R, Kashyap M, Prasad M. U. R, Mohapatra P, Das D, Satapathy SR, Siddharth S, Jain V, Choudhuri M, Kundu CN, Guchhait SK, Bharatam PV. Structural elaboration of a natural product: Identification of 3,3′-diindolylmethane aminophosphonate and urea derivatives as potent anticancer agents Chemmedchem. 8: 1873-1884. PMID 23983049 DOI: 10.1002/Cmdc.201300273  0.827
2013 Kashyap M, Kandekar S, Baviskar AT, Das D, Preet R, Mohapatra P, Satapathy SR, Siddharth S, Guchhait SK, Kundu CN, Banerjee UC. Indenoindolone derivatives as topoisomerase II-inhibiting anticancer agents. Bioorganic & Medicinal Chemistry Letters. 23: 934-8. PMID 23321564 DOI: 10.1016/J.Bmcl.2012.12.063  0.787
2013 Guchhait SK, Priyadarshani G, Chaudhary V, Seladiya DR, Shah TM, Bhogayta NP. One-pot preparation of isocyanides from amines and their multicomponent reactions: Crucial role of dehydrating agent and base Rsc Advances. 3: 10867-10874. DOI: 10.1039/C3Ra40347E  0.498
2012 Guchhait SK, Chaudhary V, Madaan C. A chemoselective Ugi-type reaction in water using TMSCN as a functional isonitrile equivalent: Generation of heteroaromatic molecular diversity Organic and Biomolecular Chemistry. 10: 9271-9277. PMID 23104509 DOI: 10.1039/C2Ob26733K  0.814
2012 Guchhait SK, Kandekar S, Kashyap M, Taxak N, Bharatam PV. C - H bond functionalization under metalation - Deprotonation process: Regioselective direct arylation of 3-aminoimidazo[1,2-a]pyrazine Journal of Organic Chemistry. 77: 8321-8328. PMID 22928611 DOI: 10.1021/Jo301065S  0.801
2012 Guchhait SK, Chandgude AL, Priyadarshani G. CuSO4-glucose for in situ generation of controlled Cu(I)-Cu(II) bicatalysts: multicomponent reaction of heterocyclic azine and aldehyde with alkyne, and cycloisomerization toward synthesis of N-fused imidazoles. The Journal of Organic Chemistry. 77: 4438-44. PMID 22486279 DOI: 10.1021/Jo3003024  0.789
2012 Kashyap M, Das D, Preet R, Mohapatra P, Satapathy SR, Siddharth S, Kundu CN, Guchhait SK. Scaffold hybridization in generation of indenoindolones as anticancer agents that induce apoptosis with cell cycle arrest at G2/M phase Bioorganic and Medicinal Chemistry Letters. 22: 2474-2479. PMID 22381050 DOI: 10.1016/J.Bmcl.2012.02.007  0.807
2012 K.Guchhait S, Das S, N. Jana R. Combined Effect of Hall Current and Rotation on MHDmixed Convection Oscillating Flow in a Rotating Vertical Channel International Journal of Computer Applications. 49: 1-11. DOI: 10.5120/7684-0990  0.186
2012 Madaan C, Saraf S, Priyadarshani G, Reddy PP, Guchhait SK, Kunwar AC, Sridhar B. One-pot, three-step copper-catalyzed five-/four-component reaction constructs polysubstituted oxa(thia)zolidin-2-imines Synlett. 23: 1955-1959. DOI: 10.1055/S-0032-1316606  0.817
2012 Guchhait SK, Kashyap M. Friedel-crafts 3-(2-bromobenzoylation) of indoles and intramolecular direct arylation: An efficient route to indenoindolones Synthesis. 44: 619-627. DOI: 10.1055/S-0031-1289663  0.83
2012 Guchhait SK, Kashyap M, Kandekar S. Intramolecular oxidative coupling of 3-indolylarylketones with Pd(II)-catalysis under air: Convenient access to indenoindolones Tetrahedron Letters. 53: 3919-3922. DOI: 10.1016/J.Tetlet.2012.05.076  0.804
2011 Baviskar AT, Madaan C, Preet R, Mohapatra P, Jain V, Agarwal A, Guchhait SK, Kundu CN, Banerjee UC, Bharatam PV. N-fused imidazoles as novel anticancer agents that inhibit catalytic activity of topoisomerase IIα and induce apoptosis in G1/S phase. Journal of Medicinal Chemistry. 54: 5013-30. PMID 21644529 DOI: 10.1021/Jm200235U  0.81
2011 Guchhait SK, Kashyap M, Kamble H. ZrCl4-mediated regio- and chemoselective friedel-crafts acylation of indole Journal of Organic Chemistry. 76: 4753-4758. PMID 21526849 DOI: 10.1021/Jo200561F  0.807
2011 Guchhait S, Das S, Jana RN, Ghosh SK. Combined Effects of Hall Current and Rotation on Unsteady Couette Flow in a Porous Channel World Journal of Mechanics. 1: 87-99. DOI: 10.4236/WJM.2011.13013  0.191
2011 Guchhait SK, Madaan C. Groebke-Blackburn-Bienaymé multicomponent reaction in scaffold-modification of adenine, guanine, and cytosine: Synthesis of aminoimidazole-condensed nucleobases Tetrahedron Letters. 52: 56-58. DOI: 10.1016/J.Tetlet.2010.10.143  0.819
2010 Guchhait SK, Madaan C. Towards molecular diversity: Dealkylation of tert-butyl amine in Ugi-type multicomponent reaction product establishes tert-butyl isocyanide as a useful convertible isonitrile Organic and Biomolecular Chemistry. 8: 3631-3634. PMID 20574586 DOI: 10.1039/C0Ob00022A  0.81
2010 Guchhait SK, Kashyap M, Saraf S. Direct C-H bond arylation of (Hetero)arenes with Aryl and heteroarylboronic acids Synthesis. 1166-1170. DOI: 10.1055/S-0029-1219234  0.791
2009 Guchhait SK, Madaan C, Thakkar BS. A highly flexible and efficient ugi-type multicomponent synthesis of versatile n-fused aminoimidazoles Synthesis. 3293-3300. DOI: 10.1055/S-0029-1216916  0.815
2009 Guchhait SK, Madaan C. An efficient, regioselective, versatile synthesis of N-fused 2- and 3-aminoimidazoles via Ugi-type multicomponent reaction mediated by zirconium(IV) chloride in polyethylene glycol-400 Synlett. 628-632. DOI: 10.1055/S-0028-1087915  0.816
2009 Guchhait SK, Jadeja K, Madaan C. A new process of multicomponent Povarov reaction-aerobic dehydrogenation: synthesis of polysubstituted quinolines Tetrahedron Letters. 50: 6861-6865. DOI: 10.1016/J.Tetlet.2009.09.125  0.811
2008 Beshir AB, Guchhait SK, Gascón JA, Fenteany G. Synthesis and structure-activity relationships of metal-ligand complexes that potently inhibit cell migration. Bioorganic & Medicinal Chemistry Letters. 18: 498-504. PMID 18240381 DOI: 10.1016/J.Bmcl.2007.11.099  0.774
2004 Kabalka GW, Guchhait SK, Naravane A. Convenient synthesis of α,β-unsaturated phosphonates via a Mizoroki-Heck reaction of arylboronic acids with diethyl vinylphosphonate Tetrahedron Letters. 45: 4685-4687. DOI: 10.1016/J.Tetlet.2004.04.094  0.545
2004 Kabalka GW, Guchhait SK. Convenient synthesis of α,β-unsaturated sulfones via a Mizoroki-Heck reaction of arylboronic acids with phenyl vinyl sulfones Tetrahedron Letters. 45: 4021-4022. DOI: 10.1016/J.Tetlet.2004.03.179  0.553
2003 Kabalka GW, Guchhait SK. Synthesis of diprotected monosubstituted hydrazine derivatives from tert-butyl carbazates and boronic acids. Organic Letters. 5: 4129-31. PMID 14572266 DOI: 10.1021/Ol035544V  0.581
2003 Kabalka GW, Guchhait SK. Synthesis of (e)- and (z)- alkenylphosphonates using vinylboronates. Organic Letters. 5: 729-31. PMID 12605501 DOI: 10.1021/Ol027515A  0.552
2002 Ranu BC, Samanta S, Guchhait SK. Zinc tetrafluoroborate catalyzed Mannich-type reaction of aldimines and silyl enol ethers in aqueous medium Tetrahedron. 58: 983-988. DOI: 10.1016/S0040-4020(01)01177-2  0.764
2001 Ranu BC, Dutta J, Guchhait SK. Selective reduction of terminal alkynes to alkenes by indium metal. The Journal of Organic Chemistry. 66: 5624-6. PMID 11485495 DOI: 10.1021/Jo010262Z  0.612
2001 Ranu BC, Dutta J, Guchhait SK. Indium metal as a reducing agent. Selective reduction of the carbon-carbon double bond in highly activated conjugated alkenes. Organic Letters. 3: 2603-5. PMID 11483071 DOI: 10.1021/Ol016296A  0.644
2001 Ranu BC, Samanta S, Guchhait SK. Stereoselective reduction of aryl-substituted gem-dibromides to vinyl bromides by indium metal Journal of Organic Chemistry. 66: 4102-4103. PMID 11375049 DOI: 10.1021/Jo0102314  0.754
2000 Ranu BC, Guchhait SK, Ghosh K, Patra A. Construction of bicyclo[2.2.2]octanone systems by microwave-assisted solid phase Michael addition followed by Al2O3-mediated intramolecular aldolisation. An eco-friendly approach Green Chemistry. 2: 5-6. DOI: 10.1039/A907689A  0.634
1998 Ranu BC, Guchhait SK, Sarkar A. Stereoselective debromination of aryl-substituted vic-dibromide with indium metal Chemical Communications. 2113-2114. DOI: 10.1039/A806530F  0.643
1998 Ranu BC, Guchhait SK, Ghosh K. Chemoselective Hydrogenation of α,β-Unsaturated Sulfones and Phosphonates via Palladium-Assisted Hydrogen Transfer by Ammonium Formate The Journal of Organic Chemistry. 63: 5250-5251. DOI: 10.1021/Jo980128N  0.604
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