Chang-Guo Zhan - Publications

Affiliations: 
Chemistry Pacific Northwest National Laboratory, USA 

56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 McNeill AS, Zhan CG, Appel AM, Stanbury DM, Dixon DA. The H•/H Redox Couple and Absolute Hydration Energy of H. The Journal of Physical Chemistry. A. PMID 32574051 DOI: 10.1021/acs.jpca.0c03833  1
2016 Wang G, Zhang T, Huang H, Hou S, Chen X, Zheng F, Zhan CG. Plant expression of cocaine hydrolase-Fc fusion protein for treatment of cocaine abuse. Bmc Biotechnology. 16: 72. PMID 27756365 DOI: 10.1186/s12896-016-0302-9  1
2016 Jang CH, Piao YL, Huang X, Yoon EJ, Park SH, Lee K, Zhan CG, Cho H. Modeling and Re-Engineering of Azotobacter vinelandii Alginate Lyase to Enhance Its Catalytic Efficiency for Accelerating Biofilm Degradation. Plos One. 11: e0156197. PMID 27253324 DOI: 10.1371/journal.pone.0156197  1
2016 Chen X, Zheng X, Zhan M, Zhou ZY, Zhan CG, Zheng F. Metabolic Enzymes of Cocaine Metabolite Benzoylecgonine. Acs Chemical Biology. PMID 27224254 DOI: 10.1021/acschembio.6b00277  1
2015 Chen X, Xue L, Hou S, Jin Z, Zhang T, Zheng F, Zhan CG. Long-acting cocaine hydrolase for addiction therapy. Proceedings of the National Academy of Sciences of the United States of America. PMID 26712009 DOI: 10.1073/pnas.1517713113  1
2015 Sviripa VM, Burikhanov R, Obiero JM, Yuan Y, Nickell JR, Dwoskin LP, Zhan CG, Liu C, Tsodikov OV, Rangnekar VM, Watt DS. Par-4 secretion: stoichiometry of 3-arylquinoline binding to vimentin. Organic & Biomolecular Chemistry. PMID 26548370 DOI: 10.1039/c5ob01980j  1
2015 Daffu GK, Lopez P, Katz F, Vinogradov M, Zhan CG, Landry DW, Macdonald J. Sulfhydryl-specific PEGylation of phosphotriesterase cysteine mutants for organophosphate detoxification. Protein Engineering, Design & Selection : Peds. 28: 501-6. PMID 26243887 DOI: 10.1093/protein/gzv036  1
2015 Wei D, Tang M, Zhan CG. Fundamental reaction pathway and free energy profile of proteasome inhibition by syringolin A (SylA). Organic & Biomolecular Chemistry. 13: 6857-65. PMID 26018983 DOI: 10.1039/c5ob00737b  1
2015 Yao M, Chen X, Zhan CG. Reaction Pathway and Free Energy Barrier for Urea Elimination in Aqueous Solution. Chemical Physics Letters. 625: 143-146. PMID 25821238 DOI: 10.1016/j.cplett.2015.02.048  1
2015 Yuan Y, Huang X, Midde NM, Quizon PM, Sun WL, Zhu J, Zhan CG. Molecular mechanism of HIV-1 Tat interacting with human dopamine transporter. Acs Chemical Neuroscience. 6: 658-65. PMID 25695767 DOI: 10.1021/acschemneuro.5b00001  1
2015 Miller Z, Kim KS, Lee DM, Kasam V, Baek SE, Lee KH, Zhang YY, Ao L, Carmony K, Lee NR, Zhou S, Zhao Q, Jang Y, Jeong HY, Zhan CG, et al. Proteasome inhibitors with pyrazole scaffolds from structure-based virtual screening. Journal of Medicinal Chemistry. 58: 2036-41. PMID 25658656 DOI: 10.1021/jm501344n  1
2015 Chen X, Huang X, Geng L, Xue L, Hou S, Zheng X, Brimijoin S, Zheng F, Zhan CG. Kinetic characterization of a cocaine hydrolase engineered from mouse butyrylcholinesterase. The Biochemical Journal. 466: 243-51. PMID 25486543 DOI: 10.1042/BJ20141266  1
2014 Hamza A, Wagner JM, Wei NN, Kwiatkowski S, Zhan CG, Watt DS, Korotkov KV. Application of the 4D fingerprint method with a robust scoring function for scaffold-hopping and drug repurposing strategies. Journal of Chemical Information and Modeling. 54: 2834-45. PMID 25229183 DOI: 10.1021/ci5003872  1
2014 Burikhanov R, Sviripa VM, Hebbar N, Zhang W, Layton WJ, Hamza A, Zhan CG, Watt DS, Liu C, Rangnekar VM. Arylquins target vimentin to trigger Par-4 secretion for tumor cell apoptosis. Nature Chemical Biology. 10: 924-6. PMID 25218743 DOI: 10.1038/nchembio.1631  1
2014 Fang L, Chow KM, Hou S, Xue L, Chen X, Rodgers DW, Zheng F, Zhan CG. Rational design, preparation, and characterization of a therapeutic enzyme mutant with improved stability and function for cocaine detoxification. Acs Chemical Biology. 9: 1764-72. PMID 24919140 DOI: 10.1021/cb500257s  1
2014 Kasam V, Lee NR, Kim KB, Zhan CG. Selective immunoproteasome inhibitors with non-peptide scaffolds identified from structure-based virtual screening. Bioorganic & Medicinal Chemistry Letters. 24: 3614-7. PMID 24913713 DOI: 10.1016/j.bmcl.2014.05.025  1
2014 Hou S, Zhan M, Zheng X, Zhan CG, Zheng F. Kinetic characterization of human butyrylcholinesterase mutants for the hydrolysis of cocaethylene. The Biochemical Journal. 460: 447-57. PMID 24870023 DOI: 10.1042/BJ20140360  1
2014 Zheng F, Xue L, Hou S, Liu J, Zhan M, Yang W, Zhan CG. A highly efficient cocaine-detoxifying enzyme obtained by computational design. Nature Communications. 5: 3457. PMID 24643289 DOI: 10.1038/ncomms4457  1
2014 Hamza A, Wagner JM, Evans TJ, Frasinyuk MS, Kwiatkowski S, Zhan CG, Watt DS, Korotkov KV. Novel mycosin protease MycP₁ inhibitors identified by virtual screening and 4D fingerprints. Journal of Chemical Information and Modeling. 54: 1166-73. PMID 24628123 DOI: 10.1021/ci500025r  1
2014 Wang X, Elshahawi SI, Shaaban KA, Fang L, Ponomareva LV, Zhang Y, Copley GC, Hower JC, Zhan CG, Kharel MK, Thorson JS. Ruthmycin, a new tetracyclic polyketide from Streptomyces sp. RM-4-15. Organic Letters. 16: 456-9. PMID 24341358 DOI: 10.1021/ol4033418  1
2013 Midde NM, Huang X, Gomez AM, Booze RM, Zhan CG, Zhu J. Mutation of tyrosine 470 of human dopamine transporter is critical for HIV-1 Tat-induced inhibition of dopamine transport and transporter conformational transitions. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 8: 975-87. PMID 23645138 DOI: 10.1007/s11481-013-9464-6  1
2013 Zheng G, Smith AM, Huang X, Subramanian KL, Siripurapu KB, Deaciuc A, Zhan CG, Dwoskin LP. Structural modifications to tetrahydropyridine-3-carboxylate esters en route to the discovery of M5-preferring muscarinic receptor orthosteric antagonists. Journal of Medicinal Chemistry. 56: 1693-703. PMID 23379472 DOI: 10.1021/jm301774u  1
2013 Zhang W, Sviripa V, Chen X, Shi J, Yu T, Hamza A, Ward ND, Kril LM, Vander Kooi CW, Zhan CG, Evers BM, Watt DS, Liu C. Fluorinated N,N-dialkylaminostilbenes repress colon cancer by targeting methionine S-adenosyltransferase 2A. Acs Chemical Biology. 8: 796-803. PMID 23363077 DOI: 10.1021/cb3005353  1
2013 Zhou M, Hamza A, Zhan CG, Thorson JS. Assessing the regioselectivity of OleD-catalyzed glycosylation with a diverse set of acceptors. Journal of Natural Products. 76: 279-86. PMID 23360118 DOI: 10.1021/np300890h  1
2013 Larrimore KE, Barcus M, Kannan L, Gao Y, Zhan CG, Brimijoin S, Mor T. Plants as a source of butyrylcholinesterase variants designed for enhanced cocaine hydrolase activity. Chemico-Biological Interactions. 203: 217-20. PMID 23000451 DOI: 10.1016/j.cbi.2012.09.004  1
2013 Wei NN, Hamza A, Hao C, Johnson-Scalise T, Xiu Z, Naftolin F, Zhan CG. Protein flexibility and conformational states of Leishmania antigen eIF-4A: identification of a novel plausible protein adjuvant using comparative genomics and molecular modeling. Journal of Biomolecular Structure & Dynamics. 31: 841-53. PMID 22963753 DOI: 10.1080/07391102.2012.713781  1
2012 Zhou M, Hou Y, Hamza A, Pain C, Zhan CG, Bugni TS, Thorson JS. Probing the regiospecificity of enzyme-catalyzed steroid glycosylation. Organic Letters. 14: 5424-7. PMID 23075289 DOI: 10.1021/ol3024924  1
2012 Liu J, Zhan CG. Reaction Pathway and Free Energy Profile for Cocaine Hydrolase-Catalyzed Hydrolysis of (-)-Cocaine. Journal of Chemical Theory and Computation. 8: 1426-1435. PMID 23066354 DOI: 10.1021/ct200810d  1
2012 Zheng F, Zhan CG. Modeling of pharmacokinetics of cocaine in human reveals the feasibility for development of enzyme therapies for drugs of abuse. Plos Computational Biology. 8: e1002610. PMID 22844238 DOI: 10.1371/journal.pcbi.1002610  1
2012 Sharma LK, Lee NR, Jang ER, Lei B, Zhan CG, Lee W, Kim KB. Activity-based near-infrared fluorescent probe for LMP7: a chemical proteomics tool for the immunoproteasome in living cells. Chembiochem : a European Journal of Chemical Biology. 13: 1899-903. PMID 22807337 DOI: 10.1002/cbic.201200307  1
2012 Zheng F, Zhan CG. Are pharmacokinetic approaches feasible for treatment of cocaine addiction and overdose? Future Medicinal Chemistry. 4: 125-8. PMID 22300091 DOI: 10.4155/fmc.11.171  1
2012 Hamza A, Wei NN, Johnson-Scalise T, Naftolin F, Cho H, Zhan CG. Unveiling the unfolding pathway of F5F8D disorder-associated D81H/V100D mutant of MCFD2 via multiple molecular dynamics simulations. Journal of Biomolecular Structure & Dynamics. 29: 699-714. PMID 22208273 DOI: 10.1080/07391102.2012.10507410  1
2012 Bargagna-Mohan P, Paranthan RR, Hamza A, Zhan CG, Lee DM, Kim KB, Lau DL, Srinivasan C, Nakayama K, Nakayama KI, Herrmann H, Mohan R. Corneal antifibrotic switch identified in genetic and pharmacological deficiency of vimentin. The Journal of Biological Chemistry. 287: 989-1006. PMID 22117063 DOI: 10.1074/jbc.M111.297150  1
2012 Carmony KC, Lee DM, Wu Y, Lee NR, Wehenkel M, Lee J, Lei B, Zhan CG, Kim KB. A bright approach to the immunoproteasome: development of LMP2/β1i-specific imaging probes. Bioorganic & Medicinal Chemistry. 20: 607-13. PMID 21741845 DOI: 10.1016/j.bmc.2011.06.039  1
2011 Zheng F, Zhan CG. Enzyme-therapy approaches for the treatment of drug overdose and addiction. Future Medicinal Chemistry. 3: 9-13. PMID 21428822 DOI: 10.4155/fmc.10.275  1
2011 Xue L, Ko MC, Tong M, Yang W, Hou S, Fang L, Liu J, Zheng F, Woods JH, Tai HH, Zhan CG. Design, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaine. Molecular Pharmacology. 79: 290-7. PMID 20971807 DOI: 10.1124/mol.110.068494  1
2010 Brim RL, Nance MR, Youngstrom DW, Narasimhan D, Zhan CG, Tesmer JJ, Sunahara RK, Woods JH. A thermally stable form of bacterial cocaine esterase: a potential therapeutic agent for treatment of cocaine abuse. Molecular Pharmacology. 77: 593-600. PMID 20086035 DOI: 10.1124/mol.109.060806  1
2010 Bargagna-Mohan P, Paranthan RR, Hamza A, Dimova N, Trucchi B, Srinivasan C, Elliott GI, Zhan CG, Lau DL, Zhu H, Kasahara K, Inagaki M, Cambi F, Mohan R. Withaferin A targets intermediate filaments glial fibrillary acidic protein and vimentin in a model of retinal gliosis. The Journal of Biological Chemistry. 285: 7657-69. PMID 20048155 DOI: 10.1074/jbc.M109.093765  1
2009 Zhan CG. Novel pharmacological approaches to treatment of drug overdose and addiction. Expert Review of Clinical Pharmacology. 2: 1-4. PMID 21072135 DOI: 10.1586/17512433.2.1.1  1
2009 Collins GT, Brim RL, Narasimhan D, Ko MC, Sunahara RK, Zhan CG, Woods JH. Cocaine esterase prevents cocaine-induced toxicity and the ongoing intravenous self-administration of cocaine in rats. The Journal of Pharmacology and Experimental Therapeutics. 331: 445-55. PMID 19710369 DOI: 10.1124/jpet.108.150029  1
2009 Hamza A, Zhan CG. Determination of the structure of human phosphodiesterase-2 in a bound state and its binding with inhibitors by molecular modeling, docking, and dynamics simulation. The Journal of Physical Chemistry. B. 113: 2896-908. PMID 19708117 DOI: 10.1021/jp8082612  1
2009 Zheng F, McConnell MJ, Zhan CG, Dwoskin LP, Crooks PA. QSAR study on maximal inhibition (Imax) of quaternary ammonium antagonists for S-(-)-nicotine-evoked dopamine release from dopaminergic nerve terminals in rat striatum. Bioorganic & Medicinal Chemistry. 17: 4477-85. PMID 19477134 DOI: 10.1016/j.bmc.2009.05.010  1
2009 Gao D, Narasimhan DL, Macdonald J, Brim R, Ko MC, Landry DW, Woods JH, Sunahara RK, Zhan CG. Thermostable variants of cocaine esterase for long-time protection against cocaine toxicity. Molecular Pharmacology. 75: 318-23. PMID 18987161 DOI: 10.1124/mol.108.049486  1
2008 Zheng F, Zhan CG. Structure-and-mechanism-based design and discovery of therapeutics for cocaine overdose and addiction Organic and Biomolecular Chemistry. 6: 836-843. PMID 18292872 DOI: 10.1039/b716268e  1
2008 Zheng F, Zhan CG. Rational design of an enzyme mutant for anti-cocaine therapeutics Journal of Computer-Aided Molecular Design. 22: 661-671. PMID 17989928 DOI: 10.1007/s10822-007-9144-9  1
2007 Bargagna-Mohan P, Hamza A, Kim YE, Khuan Abby Ho Y, Mor-Vaknin N, Wendschlag N, Liu J, Evans RM, Markovitz DM, Zhan CG, Kim KB, Mohan R. The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin. Chemistry & Biology. 14: 623-34. PMID 17584610 DOI: 10.1016/j.chembiol.2007.04.010  1
2005 Zhan CG, Gao D. Catalytic mechanism and energy barriers for butyrylcholinesterase-catalyzed hydrolysis of cocaine Biophysical Journal. 89: 3863-3872. PMID 16319079 DOI: 10.1529/biophysj.105.070276  1
2005 Gao D, Zhan CG. Modeling effects of oxyanion hole on the ester hydrolysis catalyzed by human cholinesterases Journal of Physical Chemistry B. 109: 23070-23076. DOI: 10.1021/jp053736x  1
2003 Zhan CG, Nichols JA, Dixon DA. Ionization potential, electron affinity, electronegativity, hardness, and electron excitation energy: Molecular properties from density functional theory orbital energies Journal of Physical Chemistry A. 107: 4184-4195. DOI: 10.1021/jp0225774  1
2002 Zhan CG, Zheng F, Dixon DA. Electron affinities of Al(n) clusters and multiple-fold aromaticity of the square Al4(2-) structure. Journal of the American Chemical Society. 124: 14795-803. PMID 12465993 DOI: 10.1002/chin.200309001  1
2002 Zhan CG, Dixon DA, Sabri MI, Kim MS, Spencer PS. Theoretical determination of chromophores in the chromogenic effects of aromatic neurotoxicants. Journal of the American Chemical Society. 124: 2744-52. PMID 11890826  1
2002 Zhan CG, Dixon DA. A density functional theory approach to the development of Q-e parameters for the prediction of reactivity in free-radical copolymerizations Journal of Physical Chemistry A. 106: 10311-10325. DOI: 10.1021/jp020497u  1
2002 Zhan CG, Dixon DA. First-principles determination of the absolute hydration free energy of the hydroxide ion Journal of Physical Chemistry A. 106: 9737-9744. DOI: 10.1021/jp014533l  1
2002 Zhan CG, Dixon DA. Electronic excitations in pyrrole: A test case for determination of chromophores in the chromogenic effects of neurotoxic hydrocarbons by time-dependent density functional theory and single-excitation configuration interaction methods Journal of Molecular Spectroscopy. 216: 81-89. DOI: 10.1006/jmsp.2002.8622  1
2001 Zhan CG, Dixon DA. Absolute hydration free energy of the proton from first-principles electronic structure calculations Journal of Physical Chemistry A. 105: 11534-11540. DOI: 10.1021/jp012536s  1
1991 Zhan CG. The maximum overlap symmetry orbital method and the group overlap method Journal of Molecular Structure: Theochem. 231: 57-61. DOI: 10.1016/0166-1280(91)85203-J  1
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