James A. Wells, Ph.D. - Publications

Affiliations: 
Pharmaceutical Chemistry University of California, San Francisco, San Francisco, CA 
Area:
molecular recognition
Website:
http://profiles.ucsf.edu/james.wells

192 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Muller YD, Nguyen DP, Ferreira LMR, Ho P, Raffin C, Valencia RVB, Congrave-Wilson Z, Roth TL, Eyquem J, Van Gool F, Marson A, Perez L, Wells JA, Bluestone JA, Tang Q. The CD28-Transmembrane Domain Mediates Chimeric Antigen Receptor Heterodimerization With CD28. Frontiers in Immunology. 12: 639818. PMID 33833759 DOI: 10.3389/fimmu.2021.639818  0.44
2021 Elledge SK, Zhou XX, Byrnes JR, Martinko AJ, Lui I, Pance K, Lim SA, Glasgow JE, Glasgow AA, Turcios K, Iyer NS, Torres L, Peluso MJ, Henrich TJ, Wang TT, ... ... Wells JA, et al. Engineering luminescent biosensors for point-of-care SARS-CoV-2 antibody detection. Nature Biotechnology. PMID 33767397 DOI: 10.1038/s41587-021-00878-8  0.44
2021 Weeks AM, Byrnes JR, Lui I, Wells JA. Mapping proteolytic neo-N termini at the surface of living cells. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33536314 DOI: 10.1073/pnas.2018809118  0.96
2021 Cotton AD, Nguyen DP, Gramespacher JA, Seiple IB, Wells JA. Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1. Journal of the American Chemical Society. PMID 33395526 DOI: 10.1021/jacs.0c10008  0.44
2020 Bracken CJ, Lim SA, Solomon P, Rettko NJ, Nguyen DP, Zha BS, Schaefer K, Byrnes JR, Zhou J, Lui I, Liu J, Pance K, Zhou XX, Leung KK, ... Wells JA, et al. Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2. Nature Chemical Biology. PMID 33082574 DOI: 10.1038/s41589-020-00679-1  0.44
2020 Elledge SK, Zhou XX, Byrnes JR, Martinko AJ, Lui I, Pance K, Lim SA, Glasgow JE, Glasgow AA, Turcios K, Iyer N, Torres L, Peluso MJ, Henrich TJ, Wang TT, ... ... Wells JA, et al. Engineering luminescent biosensors for point-of-care SARS-CoV-2 antibody detection. Medrxiv : the Preprint Server For Health Sciences. PMID 32839788 DOI: 10.1101/2020.08.17.20176925  0.44
2020 Bracken CJ, Lim SA, Solomon P, Rettko NJ, Nguyen DP, Zha BS, Schaefer K, Byrnes JR, Zhou J, Lui I, Liu J, Pance K, Zhou XX, Leung KK, Wells JA. Bi-paratopic and multivalent human VH domains neutralize SARS-CoV-2 by targeting distinct epitopes within the ACE2 binding interface of Spike. Biorxiv : the Preprint Server For Biology. PMID 32817948 DOI: 10.1101/2020.08.08.242511  0.44
2020 Lim DC, Joukov V, Rettenmaier TJ, Kumagai A, Dunphy WG, Wells JA, Yaffe MB. Redox priming promotes Aurora A activation during mitosis. Science Signaling. 13. PMID 32694171 DOI: 10.1126/Scisignal.Abb6707  0.44
2020 Harvey EP, Hauseman ZJ, Cohen DT, Rettenmaier TJ, Lee S, Huhn AJ, Wales TE, Seo HS, Luccarelli J, Newman CE, Guerra RM, Bird GH, Dhe-Paganon S, Engen JR, Wells JA, et al. Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering. Cell Chemical Biology. PMID 32413285 DOI: 10.1016/J.Chembiol.2020.04.004  0.44
2020 Moroz A, Wang YH, Sharib JM, Wei J, Zhao N, Huang Y, Chen Z, Martinko AJ, Zhou J, Lim SA, Zhang LH, Seo Y, Carlin S, Leung KK, Collisson EA, ... ... Wells JA, et al. Theranostic targeting of CUB domain containing protein 1 (CDCP1) in pancreatic cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 32341034 DOI: 10.1158/1078-0432.Ccr-20-0268  0.44
2020 Elledge SK, Tran HL, Christian AH, Steri V, Hann B, Toste FD, Chang CJ, Wells JA. Systematic identification of engineered methionines and oxaziridines for efficient, stable, and site-specific antibody bioconjugation. Proceedings of the National Academy of Sciences of the United States of America. PMID 32123103 DOI: 10.1073/Pnas.1920561117  0.36
2020 Weeks AM, Wells JA. N-Terminal Modification of Proteins with Subtiligase Specificity Variants. Current Protocols in Chemical Biology. 12: e79. PMID 32074409 DOI: 10.1002/Cpch.79  0.96
2019 Weeks AM, Wells JA. Subtiligase-Catalyzed Peptide Ligation. Chemical Reviews. PMID 31663725 DOI: 10.1021/Acs.Chemrev.9B00372  0.96
2019 Hertz NT, Adams EL, Weber RA, Shen RJ, O'Rourke MK, Simon DJ, Zebroski H, Olsen O, Morgan CW, Mileur TR, Hitchcock AM, Sinnott Armstrong NA, Wainberg M, Bassik MC, Molina H, ... Wells JA, et al. Neuronally Enriched RUFY3 Is Required for Caspase-Mediated Axon Degeneration. Neuron. PMID 31221560 DOI: 10.1016/J.Neuron.2019.05.030  0.36
2018 Mou Y, Zhou X, Leung K, Martinko AJ, Yu JY, Chen W, Wells JA. Engineering improved anti-phosphotyrosine antibodies based on immuno-convergent binding motif. Journal of the American Chemical Society. PMID 30398859 DOI: 10.1021/jacs.8b08402  0.44
2018 Henderson AR, Henley MJ, Foster NJ, Peiffer AL, Beyersdorf MS, Stanford KD, Sturlis SM, Linhares BM, Hill ZB, Wells JA, Cierpicki T, Brooks CL, Fierke CA, Mapp AK. Conservation of coactivator engagement mechanism enables small-molecule allosteric modulators. Proceedings of the National Academy of Sciences of the United States of America. PMID 30127017 DOI: 10.1073/Pnas.1806202115  0.44
2018 Hill ME, Kumar A, Wells JA, Hobman TC, Julien O, Hardy JA. The unique cofactor region of Zika virus NS2B-NS3 protease facilitates cleavage of key host proteins. Acs Chemical Biology. PMID 30080377 DOI: 10.1021/Acschembio.8B00508  0.32
2018 Keedy DA, Hill ZB, Biel JT, Kang E, Rettenmaier TJ, Brandao-Neto J, Pearce NM, von Delft F, Wells JA, Fraser JS. An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering. Elife. 7. PMID 29877794 DOI: 10.7554/Elife.36307  0.44
2018 Spangler B, Kline T, Hanson J, Li X, Zhou S, Wells JA, Sato AK, Renslo AR. Toward a Ferrous Iron-Cleavable Linker for Antibody-Drug Conjugates. Molecular Pharmaceutics. PMID 29569925 DOI: 10.1021/Acs.Molpharmaceut.8B00242  0.36
2018 Pollock SB, Hu A, Mou Y, Martinko AJ, Julien O, Hornsby M, Ploder L, Adams JJ, Geng H, Müschen M, Sidhu SS, Moffat J, Wells JA. Highly multiplexed and quantitative cell-surface protein profiling using genetically barcoded antibodies. Proceedings of the National Academy of Sciences of the United States of America. PMID 29476010 DOI: 10.1073/Pnas.1721899115  0.44
2018 Martinko AJ, Truillet C, Julien O, Diaz J, Horlbeck MA, Whiteley G, Blonder J, Weissman JS, Bandyopadhyay S, Evans M, Wells JA. Targeting RAS driven human cancer cells with antibodies to upregulated and essential cell-surface proteins. Elife. 7. PMID 29359686 DOI: 10.7554/Elife.31098  0.44
2017 Hill ZB, Martinko AJ, Nguyen DP, Wells JA. Human antibody-based chemically induced dimerizers for cell therapeutic applications. Nature Chemical Biology. PMID 29200207 DOI: 10.1038/Nchembio.2529  0.44
2017 Weeks AM, Wells JA. Engineering peptide ligase specificity by proteomic identification of ligation sites. Nature Chemical Biology. PMID 29155430 DOI: 10.1038/Nchembio.2521  0.96
2017 Srinivasan SR, Cesa LC, Li X, Julien O, Zhuang M, Shao H, Chung J, Maillard I, Wells JA, Duckett C, Gestwicki JE. Heat Shock Protein 70 (Hsp70) Suppresses RIP1-dependent Apoptotic and Necroptotic Cascades. Molecular Cancer Research : McR. PMID 28970360 DOI: 10.1158/1541-7786.Mcr-17-0408  0.32
2017 Diaz JE, Morgan CW, Minogue CE, Hebert AS, Coon JJ, Wells JA. A Split-Abl Kinase for Direct Activation in Cells. Cell Chemical Biology. PMID 28919041 DOI: 10.1016/J.Chembiol.2017.08.007  0.36
2017 Smart AD, Pache RA, Thomsen ND, Kortemme T, Davis GW, Wells JA. Engineering a light-activated caspase-3 for precise ablation of neurons in vivo. Proceedings of the National Academy of Sciences of the United States of America. PMID 28893998 DOI: 10.1073/Pnas.1705064114  0.44
2017 Julien O, Wells JA. Caspases and their substrates. Cell Death and Differentiation. PMID 28498362 DOI: 10.1038/Cdd.2017.44  0.32
2017 Lin S, Yang X, Jia S, Weeks AM, Hornsby M, Lee PS, Nichiporuk RV, Iavarone AT, Wells JA, Toste FD, Chang CJ. Redox-based reagents for chemoselective methionine bioconjugation. Science (New York, N.Y.). 355: 597-602. PMID 28183972 DOI: 10.1126/Science.Aal3316  0.96
2017 Tran HL, Lexa KW, Julien O, Young TS, Walsh CT, Jacobson MP, Wells JA. SAR and molecular mechanics reveal the importance of ring entropy in the biosynthesis and activity of a natural product. Journal of the American Chemical Society. PMID 28170244 DOI: 10.1021/Jacs.6B10792  0.68
2017 Calvo SE, Julien O, Clauser KR, Shen H, Kamer KJ, Wells JA, Mootha VK. Comparative analysis of mitochondrial N-termini from mouse, human, and yeast. Molecular & Cellular Proteomics : McP. PMID 28122942 DOI: 10.1074/Mcp.M116.063818  0.32
2016 Spangler B, Fontaine SD, Shi Y, Sambucetti L, Mattis AN, Hann B, Wells JA, Renslo AR. A Novel Tumor-Activated Prodrug Strategy Targeting Ferrous Iron Is Effective in Multiple Preclinical Cancer Models. Journal of Medicinal Chemistry. PMID 27936709 DOI: 10.1021/Acs.Jmedchem.6B01470  0.36
2016 Hill ZB, Pollock SB, Zhuang M, Wells JA. Direct proximity tagging of small molecule protein targets using an engineered NEDD8 ligase. Journal of the American Chemical Society. PMID 27626304 DOI: 10.1021/Jacs.6B06828  0.44
2016 Wang W, Nguyen LT, Burlak C, Chegini F, Guo F, Chataway T, Ju S, Fisher OS, Miller DW, Datta D, Wu F, Wu CX, Landeru A, Wells JA, Cookson MR, et al. Caspase-1 causes truncation and aggregation of the Parkinson's disease-associated protein α-synuclein. Proceedings of the National Academy of Sciences of the United States of America. PMID 27482083 DOI: 10.1073/Pnas.1610099113  0.36
2016 Spangler B, Morgan CW, Fontaine SD, Vander Wal MN, Chang CJ, Wells JA, Renslo AR. A reactivity-based probe of the intracellular labile ferrous iron pool. Nature Chemical Biology. PMID 27376690 DOI: 10.1038/Nchembio.2116  0.36
2016 Seaman JE, Julien O, Lee PS, Rettenmaier TJ, Thomsen ND, Wells JA. Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues. Cell Death and Differentiation. PMID 27367566 DOI: 10.1038/Cdd.2016.62  1
2016 Nguyen DP, Miyaoka Y, Gilbert LA, Mayerl SJ, Lee BH, Weissman JS, Conklin BR, Wells JA. Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity. Nature Communications. 7: 12009. PMID 27363581 DOI: 10.1038/Ncomms12009  0.44
2016 Hill ME, MacPherson DJ, Wu P, Julien O, Wells JA, Hardy JA. Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition. Acs Chemical Biology. PMID 27032039 DOI: 10.1021/Acschembio.5B00971  0.32
2016 Julien O, Zhuang M, Wiita AP, O'Donoghue AJ, Knudsen GM, Craik CS, Wells JA. Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles. Proceedings of the National Academy of Sciences of the United States of America. PMID 27006500 DOI: 10.1073/Pnas.1524900113  1
2016 Cimermancic P, Weinkam P, Rettenmaier TJ, Bichmann L, Keedy DA, Woldeyes RA, Schneidmann D, Demerdash ON, Mitchell JC, Wells JA, Fraser JS, Sali A. CryptoSite: Expanding the Druggable Proteome by Characterization and Prediction of Cryptic Binding Sites. Journal of Molecular Biology. PMID 26854760 DOI: 10.1016/J.Jmb.2016.01.029  0.44
2016 Bressler SB, Glassman A, Almukhtar T, Bressler N, Ferris FL, Googe JM, Gupta SK, Jampol LM, Melia M, Wells JA. Five Year Outcomes of Ranibizumab with Prompt or Deferred Laser versus Laser or Triamcinolone Plus Deferred Ranibizumab for Diabetic Macular Edema. American Journal of Ophthalmology. PMID 26802783 DOI: 10.1016/j.ajo.2015.12.025  0.32
2015 Rettenmaier TJ, Fan H, Karpiak J, Doak A, Sali A, Shoichet BK, Wells JA. Small-Molecule Allosteric Modulators of the Protein Kinase PDK1 from Structure-Based Docking. Journal of Medicinal Chemistry. 58: 8285-91. PMID 26443011 DOI: 10.1021/Acs.Jmedchem.5B01216  1
2015 Hornsby M, Paduch M, Miersch S, Sääf A, Matsuguchi T, Lee B, Wypisniak K, Doak A, King D, Usatyuk S, Perry K, Lu V, Thomas W, Luke J, Goodman J, ... ... Wells J, et al. A High Through-put Platform for Recombinant Antibodies to Folded Proteins. Molecular & Cellular Proteomics : McP. PMID 26290498 DOI: 10.1074/Mcp.O115.052209  1
2015 Morgan CW, Diaz JE, Zeitlin SG, Gray DC, Wells JA. Engineered cellular gene-replacement platform for selective and inducible proteolytic profiling. Proceedings of the National Academy of Sciences of the United States of America. PMID 26106156 DOI: 10.1073/Pnas.1504141112  1
2015 Koerber JT, Hornsby MJ, Wells JA. An improved single-chain Fab platform for efficient display and recombinant expression. Journal of Molecular Biology. 427: 576-86. PMID 25481745 DOI: 10.1016/J.Jmb.2014.11.017  1
2014 Rettenmaier TJ, Sadowsky JD, Thomsen ND, Chen SC, Doak AK, Arkin MR, Wells JA. A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1. Proceedings of the National Academy of Sciences of the United States of America. 111: 18590-5. PMID 25518860 DOI: 10.1073/Pnas.1415365112  1
2014 Julien O, Kampmann M, Bassik MC, Zorn JA, Venditto VJ, Shimbo K, Agard NJ, Shimada K, Rheingold AL, Stockwell BR, Weissman JS, Wells JA. Unraveling the mechanism of cell death induced by chemical fibrils. Nature Chemical Biology. 10: 969-76. PMID 25262416 DOI: 10.1038/Nchembio.1639  1
2014 Arkin MR, Tang Y, Wells JA. Small-molecule inhibitors of protein-protein interactions: progressing toward the reality. Chemistry & Biology. 21: 1102-14. PMID 25237857 DOI: 10.1016/J.Chembiol.2014.09.001  1
2014 Wiita AP, Seaman JE, Wells JA. Global analysis of cellular proteolysis by selective enzymatic labeling of protein N-termini. Methods in Enzymology. 544: 327-58. PMID 24974296 DOI: 10.1016/B978-0-12-417158-9.00013-3  1
2014 Morgan CW, Julien O, Unger EK, Shah NM, Wells JA. Turning on caspases with genetics and small molecules. Methods in Enzymology. 544: 179-213. PMID 24974291 DOI: 10.1016/B978-0-12-417158-9.00008-X  1
2014 Wells JA, Kossiakoff AA. Cell biology. New tricks for an old dimer. Science (New York, N.Y.). 344: 703-4. PMID 24833381 DOI: 10.1126/Science.1254799  1
2014 Wiita AP, Hsu GW, Lu CM, Esensten JH, Wells JA. Circulating proteolytic signatures of chemotherapy-induced cell death in humans discovered by N-terminal labeling. Proceedings of the National Academy of Sciences of the United States of America. 111: 7594-9. PMID 24821784 DOI: 10.1073/Pnas.1405987111  1
2014 Lodge JM, Rettenmaier TJ, Wells JA, Pomerantz WC, Mapp AK. FP Tethering: a screening technique to rapidly identify compounds that disrupt protein-protein interactions. Medchemcomm. 5: 370-375. PMID 24795804 DOI: 10.1039/C3Md00356F  1
2013 Wiita AP, Ziv E, Wiita PJ, Urisman A, Julien O, Burlingame AL, Weissman JS, Wells JA. Global cellular response to chemotherapy-induced apoptosis. Elife. 2: e01236. PMID 24171104 DOI: 10.7554/Elife.01236  1
2013 Koerber JT, Thomsen ND, Hannigan BT, Degrado WF, Wells JA. Nature-inspired design of motif-specific antibody scaffolds. Nature Biotechnology. 31: 916-21. PMID 23955275 DOI: 10.1038/Nbt.2672  1
2013 Carter PJ, Hazuda D, Wells JA. Next generation therapeutics. Current Opinion in Chemical Biology. 17: 317-9. PMID 23683350 DOI: 10.1016/J.Cbpa.2013.04.022  1
2013 Yang CF, Chiang MC, Gray DC, Prabhakaran M, Alvarado M, Juntti SA, Unger EK, Wells JA, Shah NM. Sexually dimorphic neurons in the ventromedial hypothalamus govern mating in both sexes and aggression in males. Cell. 153: 896-909. PMID 23663785 DOI: 10.1016/J.Cell.2013.04.017  1
2013 Thomsen ND, Koerber JT, Wells JA. Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation. Proceedings of the National Academy of Sciences of the United States of America. 110: 8477-82. PMID 23650375 DOI: 10.1073/Pnas.1306759110  1
2013 Datta D, McClendon CL, Jacobson MP, Wells JA. Substrate and inhibitor-induced dimerization and cooperativity in caspase-1 but not caspase-3. The Journal of Biological Chemistry. 288: 9971-81. PMID 23386603 DOI: 10.1074/Jbc.M112.426460  1
2013 Wang N, Majmudar CY, Pomerantz WC, Gagnon JK, Sadowsky JD, Meagher JL, Johnson TK, Stuckey JA, Brooks CL, Wells JA, Mapp AK. Ordering a dynamic protein via a small-molecule stabilizer. Journal of the American Chemical Society. 135: 3363-6. PMID 23384013 DOI: 10.1021/Ja3122334  1
2013 Crawford ED, Seaman JE, Agard N, Hsu GW, Julien O, Mahrus S, Nguyen H, Shimbo K, Yoshihara HA, Zhuang M, Chalkley RJ, Wells JA. The DegraBase: a database of proteolysis in healthy and apoptotic human cells. Molecular & Cellular Proteomics : McP. 12: 813-24. PMID 23264352 DOI: 10.1074/Mcp.O112.024372  1
2013 Zhuang M, Guan S, Wang H, Burlingame AL, Wells JA. Substrates of IAP ubiquitin ligases identified with a designed orthogonal E3 ligase, the NEDDylator. Molecular Cell. 49: 273-82. PMID 23201124 DOI: 10.1016/J.Molcel.2012.10.022  1
2013 Gao J, Wells JA. Caspase-4 and Caspase-5 Handbook of Proteolytic Enzymes. 2: 2265-2269. DOI: 10.1016/B978-0-12-382219-2.00508-1  1
2012 Crawford ED, Seaman JE, Barber AE, David DC, Babbitt PC, Burlingame AL, Wells JA. Conservation of caspase substrates across metazoans suggests hierarchical importance of signaling pathways over specific targets and cleavage site motifs in apoptosis. Cell Death and Differentiation. 19: 2040-8. PMID 22918439 DOI: 10.1038/Cdd.2012.99  1
2012 Zorn JA, Wolan DW, Agard NJ, Wells JA. Fibrils colocalize caspase-3 with procaspase-3 to foster maturation. The Journal of Biological Chemistry. 287: 33781-95. PMID 22872644 DOI: 10.1074/Jbc.M112.386128  1
2012 Shimbo K, Hsu GW, Nguyen H, Mahrus S, Trinidad JC, Burlingame AL, Wells JA. Quantitative profiling of caspase-cleaved substrates reveals different drug-induced and cell-type patterns in apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 109: 12432-7. PMID 22802652 DOI: 10.1073/Pnas.1208616109  1
2012 Agard NJ, Mahrus S, Trinidad JC, Lynn A, Burlingame AL, Wells JA. Global kinetic analysis of proteolysis via quantitative targeted proteomics. Proceedings of the National Academy of Sciences of the United States of America. 109: 1913-8. PMID 22308409 DOI: 10.1073/Pnas.1117158109  1
2012 Gao J, Wells JA. Identification of specific tethered inhibitors for caspase-5. Chemical Biology & Drug Design. 79: 209-15. PMID 22014003 DOI: 10.1111/J.1747-0285.2011.01261.X  1
2011 Zorn JA, Wille H, Wolan DW, Wells JA. Self-assembling small molecules form nanofibrils that bind procaspase-3 to promote activation. Journal of the American Chemical Society. 133: 19630-3. PMID 22066605 DOI: 10.1021/Ja208350U  1
2011 Tang Y, Wells JA, Arkin MR. Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis. The Journal of Biological Chemistry. 286: 34147-54. PMID 21828056 DOI: 10.1074/Jbc.M111.247627  1
2011 Crawford ED, Wells JA. Caspase substrates and cellular remodeling. Annual Review of Biochemistry. 80: 1055-87. PMID 21456965 DOI: 10.1146/Annurev-Biochem-061809-121639  1
2011 Sadowsky JD, Burlingame MA, Wolan DW, McClendon CL, Jacobson MP, Wells JA. Turning a protein kinase on or off from a single allosteric site via disulfide trapping. Proceedings of the National Academy of Sciences of the United States of America. 108: 6056-61. PMID 21430264 DOI: 10.1073/Pnas.1102376108  1
2011 Pérez-Payá E, Orzáez M, Mondragón L, Wolan D, Wells JA, Messeguer A, Vicent MJ. Molecules that modulate Apaf-1 activity. Medicinal Research Reviews. 31: 649-75. PMID 20099266 DOI: 10.1002/Med.20198  1
2010 Gray DC, Mahrus S, Wells JA. Activation of specific apoptotic caspases with an engineered small-molecule-activated protease. Cell. 142: 637-46. PMID 20723762 DOI: 10.1016/J.Cell.2010.07.014  1
2010 Barkan DT, Hostetter DR, Mahrus S, Pieper U, Wells JA, Craik CS, Sali A. Prediction of protease substrates using sequence and structure features. Bioinformatics (Oxford, England). 26: 1714-22. PMID 20505003 DOI: 10.1093/Bioinformatics/Btq267  1
2010 Agard NJ, Maltby D, Wells JA. Inflammatory stimuli regulate caspase substrate profiles. Molecular & Cellular Proteomics : McP. 9: 880-93. PMID 20173201 DOI: 10.1074/Mcp.M900528-Mcp200  1
2010 Wildes D, Wells JA. Sampling the N-terminal proteome of human blood. Proceedings of the National Academy of Sciences of the United States of America. 107: 4561-6. PMID 20173099 DOI: 10.1073/Pnas.0914495107  1
2010 Zorn JA, Wells JA. Turning enzymes ON with small molecules. Nature Chemical Biology. 6: 179-188. PMID 20154666 DOI: 10.1038/Nchembio.318  1
2009 Wolan DW, Zorn JA, Gray DC, Wells JA. Small-molecule activators of a proenzyme. Science (New York, N.Y.). 326: 853-8. PMID 19892984 DOI: 10.1126/Science.1177585  1
2009 Agard NJ, Wells JA. Methods for the proteomic identification of protease substrates. Current Opinion in Chemical Biology. 13: 503-9. PMID 19729334 DOI: 10.1016/J.Cbpa.2009.07.026  1
2009 Hardy JA, Wells JA. Dissecting an allosteric switch in caspase-7 using chemical and mutational probes. The Journal of Biological Chemistry. 284: 26063-9. PMID 19581639 DOI: 10.1074/Jbc.M109.001826  1
2009 Gao J, Sidhu SS, Wells JA. Two-state selection of conformation-specific antibodies. Proceedings of the National Academy of Sciences of the United States of America. 106: 3071-6. PMID 19208804 DOI: 10.1073/Pnas.0812952106  1
2008 Wells J, Woolley M. A populist movement for health? Science. 322: 15. PMID 18832612 DOI: 10.1126/Science.1163960  1
2008 Yoshihara HA, Mahrus S, Wells JA. Tags for labeling protein N-termini with subtiligase for proteomics. Bioorganic & Medicinal Chemistry Letters. 18: 6000-3. PMID 18762420 DOI: 10.1016/J.Bmcl.2008.08.044  1
2008 Mahrus S, Trinidad JC, Barkan DT, Sali A, Burlingame AL, Wells JA. Global sequencing of proteolytic cleavage sites in apoptosis by specific labeling of protein N termini. Cell. 134: 866-76. PMID 18722006 DOI: 10.1016/J.Cell.2008.08.012  1
2008 Datta D, Scheer JM, Romanowski MJ, Wells JA. An allosteric circuit in caspase-1. Journal of Molecular Biology. 381: 1157-67. PMID 18590738 DOI: 10.1016/J.Jmb.2008.06.040  1
2007 Wells JA, McClendon CL. Reaching for high-hanging fruit in drug discovery at protein-protein interfaces. Nature. 450: 1001-9. PMID 18075579 DOI: 10.1038/Nature06526  1
2007 Tóth G, Mukhyala K, Wells JA. Computational approach to site-directed ligand discovery. Proteins. 68: 551-60. PMID 17444517 DOI: 10.1002/Prot.21402  1
2006 Thanos CD, DeLano WL, Wells JA. Hot-spot mimicry of a cytokine receptor by a small molecule. Proceedings of the National Academy of Sciences of the United States of America. 103: 15422-7. PMID 17032757 DOI: 10.1073/Pnas.0607058103  1
2006 Scheer JM, Romanowski MJ, Wells JA. A common allosteric site and mechanism in caspases. Proceedings of the National Academy of Sciences of the United States of America. 103: 7595-600. PMID 16682620 DOI: 10.1073/Pnas.0602571103  1
2005 Scheer JM, Wells JA, Romanowski MJ. Malonate-assisted purification of human caspases. Protein Expression and Purification. 41: 148-53. PMID 15802232 DOI: 10.1016/J.Pep.2005.01.008  1
2005 Buck E, Wells JA. Disulfide trapping to localize small-molecule agonists and antagonists for a G protein-coupled receptor. Proceedings of the National Academy of Sciences of the United States of America. 102: 2719-24. PMID 15710877 DOI: 10.1073/Pnas.0500016102  1
2005 Buck E, Bourne H, Wells JA. Site-specific disulfide capture of agonist and antagonist peptides on the C5a receptor. The Journal of Biological Chemistry. 280: 4009-12. PMID 15550394 DOI: 10.1074/Jbc.C400500200  1
2004 Hardy JA, Wells JA. Searching for new allosteric sites in enzymes. Current Opinion in Structural Biology. 14: 706-15. PMID 15582395 DOI: 10.1016/J.Sbi.2004.10.009  1
2004 Hardy JA, Lam J, Nguyen JT, O'Brien T, Wells JA. Discovery of an allosteric site in the caspases. Proceedings of the National Academy of Sciences of the United States of America. 101: 12461-6. PMID 15314233 DOI: 10.1073/Pnas.0404781101  1
2004 Martin AG, Nguyen J, Wells JA, Fearnhead HO. Apo cytochrome c inhibits caspases by preventing apoptosome formation. Biochemical and Biophysical Research Communications. 319: 944-50. PMID 15184073 DOI: 10.1016/J.Bbrc.2004.05.084  1
2004 Erlanson DA, Wells JA, Braisted AC. Tethering: fragment-based drug discovery. Annual Review of Biophysics and Biomolecular Structure. 33: 199-223. PMID 15139811 DOI: 10.1146/Annurev.Biophys.33.110502.140409  1
2004 Stroud RM, Wells JA. Mechanistic diversity of cytokine receptor signaling across cell membranes. Science's Stke : Signal Transduction Knowledge Environment. 2004: re7. PMID 15126678 DOI: 10.1126/Stke.2312004Re7  1
2004 Arkin MR, Wells JA. Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nature Reviews. Drug Discovery. 3: 301-17. PMID 15060526 DOI: 10.1038/Nrd1343  1
2003 Thanos CD, Randal M, Wells JA. Potent small-molecule binding to a dynamic hot spot on IL-2. Journal of the American Chemical Society. 125: 15280-1. PMID 14664558 DOI: 10.1021/Ja0382617  1
2003 Nguyen JT, Wells JA. Direct activation of the apoptosis machinery as a mechanism to target cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 100: 7533-8. PMID 12808146 DOI: 10.1073/Pnas.1031631100  1
2003 Wells J, Arkin M, Braisted A, DeLano W, McDowell B, Oslob J, Raimundo B, Randal M. Drug discovery at signaling interfaces. Ernst Schering Research Foundation Workshop. 19-27. PMID 12664533 DOI: 10.1007/978-3-662-05314-0_3  1
2003 Arkin MR, Randal M, DeLano WL, Hyde J, Luong TN, Oslob JD, Raphael DR, Taylor L, Wang J, McDowell RS, Wells JA, Braisted AC. Binding of small molecules to an adaptive protein-protein interface. Proceedings of the National Academy of Sciences of the United States of America. 100: 1603-8. PMID 12582206 DOI: 10.1073/Pnas.252756299  1
2002 Cancilla MT, Erlanson DA, Braisted AC, Randal M, Arkin M, Gordon EM, Wells JA. Discovering antagonists of enzymes and protein: Protein interactions using a high throughput screening mass spectrometry method termed "tethering" Proceedings 50th Asms Conference On Mass Spectrometry and Allied Topics. 89-90.  1
2000 Sidhu SS, Lowman HB, Cunningham BC, Wells JA. Phage display for selection of novel binding peptides Methods in Enzymology. 328: 333-363. PMID 11075354 DOI: 10.1016/S0076-6879(00)28406-1  1
2000 Erlanson DA, Braisted AC, Raphael DR, Randal M, Stroud RM, Gordon EM, Wells JA. Site-directed ligand discovery. Proceedings of the National Academy of Sciences of the United States of America. 97: 9367-72. PMID 10944209 DOI: 10.1073/Pnas.97.17.9367  1
2000 Weiss GA, Wells JA, Sidhu SS. Mutational analysis of the major coat protein of M13 identifies residues that control protein display. Protein Science : a Publication of the Protein Society. 9: 647-54. PMID 10794407 DOI: 10.1110/Ps.9.4.647  1
2000 DeLano WL, Ultsch MH, De Vos AM, Wells JA. Convergent solutions to binding at a protein-protein interface Science. 287: 1279-1283. PMID 10678837 DOI: 10.1126/Science.287.5456.1279  1
2000 Sidhu SS, Weiss GA, Wells JA. High copy display of large proteins on phage for functional selections. Journal of Molecular Biology. 296: 487-95. PMID 10669603 DOI: 10.1006/Jmbi.1999.3465  1
1999 Atwell S, Wells JA. Selection for improved subtiligases by phage display Proceedings of the National Academy of Sciences of the United States of America. 96: 9497-9502. PMID 10449721 DOI: 10.1073/Pnas.96.17.9497  1
1999 Pearce KH, Cunningham BC, Fuh G, Teeri T, Wells JA. Growth hormone binding affinity for its receptor surpasses the requirements for cellular activity Biochemistry. 38: 81-89. PMID 9890885 DOI: 10.1021/Bi9817008  1
1998 Fairbrother WJ, Christinger HW, Cochran AG, Fuh G, Keenan CJ, Quan C, Shriver SK, Tom JYK, Wells JA, Cunningham BC. Novel peptides selected to bind vascular endothelial growth factor target the receptor-binding site Biochemistry. 37: 17754-17764. PMID 9922141 DOI: 10.1021/Bi981931E  1
1998 Arkin MR, Wells JA. Probing the importance of second sphere residues in an esterolytic antibody by phage display Journal of Molecular Biology. 284: 1083-1094. PMID 9837728 DOI: 10.1006/Jmbi.1998.2234  1
1998 Ballinger MD, Wells JA. Will any dimer do? Nature Structural Biology. 5: 938-940. PMID 9808034 DOI: 10.1038/2911  1
1998 Clackson T, Ultsch MH, Wells JA, De Vos AM. Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity Journal of Molecular Biology. 277: 1111-1128. PMID 9571026 DOI: 10.1006/Jmbi.1998.1669  1
1998 Ballinger MD, Jones JT, Lofgren JA, Fairbrother WJ, Akita RW, Sliwkowski MX, Wells JA. Selection of heregulin variants having higher affinity for the ErbB3 receptor by monovalent phage display Journal of Biological Chemistry. 273: 11675-11684. PMID 9565588 DOI: 10.1074/Jbc.273.19.11675  1
1998 Fuh G, Li B, Crowley C, Cunningham B, Wells JA. Requirements for binding and signaling of the kinase domain receptor for vascular endothelial growth factor Journal of Biological Chemistry. 273: 11197-11204. PMID 9556609 DOI: 10.1074/Jbc.273.18.11197  1
1998 Jones JT, Ballinger MD, Pisacane PI, Lofgren JA, Fitzpatrick VD, Fairbrother WJ, Wells JA, Sliwkowski MX. Binding interaction of the heregulinβ egf domain with ErbB3 and ErbB4 receptors assessed by alanine scanning mutagenesis Journal of Biological Chemistry. 273: 11667-11674. DOI: 10.1074/Jbc.273.19.11667  1
1998 Erlanson DA, Wells JA. Facile synthesis of cyclic peptides containing di-, tri-, tetra-, and pentasulfides Tetrahedron Letters. 39: 6799-6802. DOI: 10.1016/S0040-4039(98)01461-0  1
1997 Wiesmann C, Fuh G, Christinger HW, Eigenbrot C, Wells JA, De Vos AM. Crystal structure at 1.7 Å resolution f VEGF in complex with domain 2 of the Fit-1 receptor Cell. 91: 695-704. PMID 9393862 DOI: 10.1016/S0092-8674(00)80456-0  1
1997 Braisted AC, Judice JK, Wells JA. Synthesis of proteins by subtiligase Methods in Enzymology. 289: 298-313. PMID 9353727 DOI: 10.1016/S0076-6879(97)89053-2  1
1997 Atwell S, Ultsch M, De Vos AM, Wells JA. Structural plasticity in a remodeled protein-protein interface Science. 278: 1125-1128. PMID 9353194 DOI: 10.1126/Science.278.5340.1125  1
1997 Scheidig AJ, Hynes TR, Pelletier LA, Wells JA, Kossiakoff AA. Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities. Protein Science : a Publication of the Protein Society. 6: 1806-24. PMID 9300481 DOI: 10.1002/Pro.5560060902  1
1997 Starovasnik MA, Braisted AC, Wells JA. Structural mimicry of a native protein by a minimized binding domain Proceedings of the National Academy of Sciences of the United States of America. 94: 10080-10085. PMID 9294166 DOI: 10.1073/Pnas.94.19.10080  1
1997 Baca M, Scanlan TS, Stephenson RC, Wells JA. Phage display of a catalytic antibody to optimize affinity for transition-state analog binding. Proceedings of the National Academy of Sciences of the United States of America. 94: 10063-8. PMID 9294163 DOI: 10.1073/Pnas.94.19.10063  1
1997 Cunningham BC, Wells JA. Minimized proteins Current Opinion in Structural Biology. 7: 457-462. PMID 9266165 DOI: 10.1016/S0959-440X(97)80107-8  1
1997 Pearce KH, Potts BJ, Presta LG, Bald LN, Fendly BM, Wells JA. Mutational analysis of thrombopoietin for identification of receptor and neutralizing antibody sites Journal of Biological Chemistry. 272: 20595-20602. PMID 9252374 DOI: 10.1074/Jbc.272.33.20595  1
1997 Atwell S, Ridgway JBB, Wells JA, Carter P. Stable heterodimers from remodeling the domain interface of a homodimer using a phage display library Journal of Molecular Biology. 270: 26-35. PMID 9231898 DOI: 10.1006/Jmbi.1997.1116  1
1997 Muller YA, Li B, Christinger HW, Wells JA, Cunningham BC, De Vos AM. Vascular endothelial growth factor: Crystal structure and functional mapping of the kinase domain receptor binding site Proceedings of the National Academy of Sciences of the United States of America. 94: 7192-7197. PMID 9207067 DOI: 10.1073/Pnas.94.14.7192  1
1997 Baca M, Presta LG, O'Connor SJ, Wells JA. Antibody humanization using monovalent phage display Journal of Biological Chemistry. 272: 10678-10684. PMID 9099717 DOI: 10.1074/Jbc.272.16.10678  1
1997 Wells JA, Cunningham BC, Braisled A, Ullsch M, Starovasnik M, De Vos B. "from big molecules to smaller ones" Faseb Journal. 11: A1294.  1
1996 Ballinger MD, Tom J, Wells JA. Furilisin: A variant of subtilisin BPN' engineered for cleaving tribasic substrates Biochemistry. 35: 13579-13585. PMID 8885837 DOI: 10.1021/Bi961543H  1
1996 Wells JA, De Vos AM. Hematopoietic receptor complexes Annual Review of Biochemistry. 65: 609-634. PMID 8811191 DOI: 10.1146/ANNUREV.BI.65.070196.003141  1
1996 Pearce KH, Ultsch MH, Kelley RF, de Vos AM, Wells JA. Structural and mutational analysis of affinity-inert contact residues at the growth hormone-receptor interface. Biochemistry. 35: 10300-7. PMID 8756685 DOI: 10.1021/Bi960513B  1
1996 Clark R, Olson K, Fuh G, Marian M, Mortensen D, Teshima G, Chang S, Chu H, Mukku V, Canova-Davis E, Somers T, Cronin M, Winkler M, Wells JA. Long-acting growth hormones produced by conjugation with polyethylene glycol Journal of Biological Chemistry. 271: 21969-21977. PMID 8703002 DOI: 10.1074/Jbc.271.36.21969  1
1996 Braisted AC, Wells JA. Minimizing a binding domain from protein A Proceedings of the National Academy of Sciences of the United States of America. 93: 5688-5692. PMID 8650153 DOI: 10.1073/Pnas.93.12.5688  1
1996 Chang TK, Chiang Y, Guo HX, Kresge AJ, Mathew L, Powell MF, Wells JA. Solvent isotope effects in H2O-D2O mixtures (proton inventories) on serine-protease-catalyzed hydrolysis reactions. Influence of oxyanion hole interactions and medium effects Journal of the American Chemical Society. 118: 8802-8807. DOI: 10.1021/ja9614326  1
1996 Suich DJ, Ballinger MD, Wells JA, DeGrado WF. Fmoc-based synthesis of glycolate ester peptides for the assembly of de novo designed multimeric proteins using subtiligase Tetrahedron Letters. 37: 6653-6656. DOI: 10.1016/S0040-4039(96)01444-X  1
1996 Wells JA, Cunnmgham BC, Li B, Starovasnik M, Fairbrother W, Braisted A. Molecular recognition in protein complexes Faseb Journal. 10: A1419.  1
1995 Wells JA. Structural and functional epitopes in the growth hormone receptor complex: Can information from large molecules lead to the design of small molecule mimetics? Bio/Technology. 13: 647-651. PMID 9634801 DOI: 10.1038/Nbt0795-647  1
1995 Fuh G, Wells JA. Prolactin receptor antagonists that inhibit the growth of breast cancer cell lines Journal of Biological Chemistry. 270: 13133-13137. PMID 7768908 DOI: 10.1074/Jbc.270.22.13133  1
1995 Ballinger MD, Tom J, Wells JA. Designing subtilisin BPN' to cleave substrates containing dibasic residues Biochemistry. 34: 13312-13319. PMID 7577915 DOI: 10.1021/Bi00041A006  1
1995 Clackson T, Wells JA. A hot spot of binding energy in a hormone-receptor interface Science. 267: 383-386. PMID 7529940 DOI: 10.1126/Science.7529940  1
1995 Chiang Y, Kresge AJ, Chang TK, Powell F, Wells JA. Solvent isotope effects on a hydrolysis reaction catalysed by subtilisin and its N155G mutant. Failure of the proton inventory method to report hydrogen-bonding interactions in the oxyanion hole Journal of the Chemical Society, Chemical Communications. 1587-1588. DOI: 10.1039/C39950001587  1
1995 Jackson DY, Burnier JP, Wells JA. Enzymatic cyclization of linear peptide esters using subtiligase Journal of the American Chemical Society. 117: 819-820. DOI: 10.1021/Ja00107A027  1
1994 Matthews DJ, Wells JA. Engineering an interfacial zinc site to increase hormone-receptor affinity Chemistry and Biology. 1: 25-30. PMID 9383367 DOI: 10.1016/1074-5521(94)90037-X  1
1994 Jamieson AC, Kim SH, Wells JA. In vitro selection of zinc fingers with altered DNA-binding specificity Biochemistry®. 33: 5689-5695. PMID 8180194 DOI: 10.1021/Bi00185A004  1
1994 Cunningham BC, Lowe DG, Li B, Bennett BD, Wells JA. Production of an atrial natriuretic peptide variant that is specific for type A receptor. The Embo Journal. 13: 2508-15. PMID 8013451 DOI: 10.1002/J.1460-2075.1994.Tb06540.X  1
1994 Jackson DY, Burnier J, Quan C, Stanley M, Tom J, Wells JA. A designed peptide ligase for total synthesis of ribonuclease A with unnatural catalytic residues. Science (New York, N.Y.). 266: 243-7. PMID 7939659 DOI: 10.1126/Science.7939659  0.6
1994 Chang TK, Jackson DY, Burnier JP, Wells JA. Subtiligase: a tool for semisynthesis of proteins. Proceedings of the National Academy of Sciences of the United States of America. 91: 12544-8. PMID 7809074 DOI: 10.1073/Pnas.91.26.12544  0.6
1994 Clackson T, Wells JA. In vitro selection from protein and peptide libraries Trends in Biotechnology. 12: 173-184. PMID 7764900 DOI: 10.1016/0167-7799(94)90079-5  1
1994 Jin L, Wells JA. Dissecting the energetics of an antibody-antigen interface by alanine shaving and molecular grafting Protein Science. 3: 2351-2357. PMID 7538848 DOI: 10.1002/Pro.5560031219  1
1994 Jin L, Cohen FE, Wells JA. Structure from function: Screening structural models with functional data Proceedings of the National Academy of Sciences of the United States of America. 91: 113-117. PMID 7506411 DOI: 10.1073/Pnas.91.1.113  1
1993 Matthews DJ, Wells JA. Substrate phage: Selection of protease substrates by monovalent phage display Science. 260: 1113-1117. PMID 8493554 DOI: 10.1126/Science.8493554  1
1993 Feldman M, Ruan W, Cunningham BC, Wells JA, Kleinberg DL. Evidence that the growth hormone receptor mediates differentiation and development of the mammary gland Endocrinology. 133: 1602-1608. PMID 8404600 DOI: 10.1210/Endo.133.4.8404600  1
1993 Lowman HB, Wells JA. Affinity maturation of human growth hormone by monovalent phage display Journal of Molecular Biology. 234: 564-478. PMID 8254660 DOI: 10.1006/Jmbi.1993.1612  1
1993 Cunningham BC, Wells JA. Comparison of a structural and a functional epitope Journal of Molecular Biology. 234: 554-563. PMID 7504735 DOI: 10.1006/Jmbi.1993.1611  1
1992 Fuh G, Cunningham BC, Fukunaga R, Nagata S, Goeddel DV, Wells JA. Rational design of potent antagonists to the human growth hormone receptor. Science (New York, N.Y.). 256: 1677-80. PMID 1535167 DOI: 10.1126/Science.256.5064.1677  1
1992 Braxton S, Wells JA. Incorporation of a stabilizing Ca(2+)-binding loop into subtilisin BPN'. Biochemistry. 31: 7796-801. PMID 1510966 DOI: 10.1021/Bi00149A008  1
1992 Weber JR, Nelson C, Cunningham BC, Wells JA, Fong S. Immunodominant structures of human growth hormone identified by homolog-scanning mutagenesis. Molecular Immunology. 29: 1081-8. PMID 1495498 DOI: 10.1016/0161-5890(92)90040-5  1
1992 Jin L, Fendly BM, Wells JA. High resolution functional analysis of antibody-antigen interactions Journal of Molecular Biology. 226: 851-865. PMID 1380563 DOI: 10.1016/0022-2836(92)90636-X  1
1991 Carter P, Abrahmsén L, Wells JA. Probing the mechanism and improving the rate of substrate-assisted catalysis in subtilisin BPN′ Biochemistry. 30: 6142-6148. PMID 2059622 DOI: 10.1021/Bi00239A009  1
1991 Wells JA. Engineering subtilisin and its substrates for efficient ligation of peptide bonds in aqueous solution Biochemistry. 30: 4151-4159. PMID 2021606 DOI: 10.1021/Bi00231A007  1
1991 Cunningham BC, Wells JA. Rational design of receptor-specific variants of human growth hormone Proceedings of the National Academy of Sciences of the United States of America. 88: 3407-3411. PMID 2014261 DOI: 10.1073/Pnas.88.8.3407  1
1991 Cunningham BC, Mulkerrin MG, Wells JA. Dimerization of human growth hormone by zinc Science. 253: 545-548. PMID 1907025 DOI: 10.1126/Science.1907025  1
1991 Wells JA. Systematic mutational analyses of protein-protein interfaces Methods in Enzymology. 202: 390-411. PMID 1723781 DOI: 10.1016/0076-6879(91)02020-A  1
1991 Lowman HB, Wells JA. Monovalent phage display: A method for selecting variant proteins from random libraries Methods. 3: 205-216. DOI: 10.1016/S1046-2023(05)80173-2  1
1990 Cunningham BC, Henner DJ, Wells JA. Engineering human prolactin to bind to the human growth hormone receptor Science. 247: 1461-1465. PMID 2321008 DOI: 10.1126/Science.2321008  1
1990 Cunningham BC, Bass S, Fuh G, Wells JA. Zinc mediation of the binding of human growth hormone to the human prolactin receptor Science. 250: 1709-1712. PMID 2270485 DOI: 10.1126/Science.2270485  1
1990 Carter P, Wells JA. Functional interaction among catalytic residues in subtilisin BPN' Proteins: Structure, Function and Genetics. 7: 335-342. PMID 2199971 DOI: 10.1002/Prot.340070405  1
1989 Carter P, Nilsson B, Burnier JP, Burdick D, Wells JA. Engineering subtilisin BPN' for site-specific proteolysis Proteins: Structure, Function and Genetics. 6: 240-248. PMID 2516317 DOI: 10.1002/Prot.340060306  1
1989 Mitchinson C, Wells JA. Protein engineering of bisulfide bonds in subtilisin BPN′ Biochemistry. 28: 4807-4815. PMID 2504281 DOI: 10.1021/Bi00437A043  1
1989 Cunningham BC, Wells JA. High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis Science. 244: 1081-1085. PMID 2471267 DOI: 10.1126/Science.2471267  1
1989 Cunningham BC, Jhurani P, Ng P, Wells JA. Receptor and antibody epitopes in human growth hormone identified by homolog-scanning mutagenesis Science. 243: 1330-1336. PMID 2466339 DOI: 10.1126/Science.2466339  1
1988 Carter P, Wells JA. Dissecting the catalytic triad of a serine protease Nature. 332: 564-568. PMID 3282170 DOI: 10.1038/332564A0  1
1988 Wells JA, Estell DA. Subtilisin - an enzyme designed to be engineered Trends in Biochemical Sciences. 13: 291-297. PMID 3154281 DOI: 10.1016/0968-0004(88)90121-1  1
1987 Cunningham BC, Wells JA. Improvement in the alkaline stability of subtilisin using an efficient random mutagenesis and screening procedure Protein Engineering, Design and Selection. 1: 319-325. PMID 3334089 DOI: 10.1093/Protein/1.4.319  1
1987 Carter P, Wells JA. Engineering enzyme specificity by 'substrate-assisted catalysis' Science. 237: 394-399. PMID 3299704 DOI: 10.1126/Science.3299704  1
1987 Wells JA, Cunningham BC, Graycar TP, Estell DA. Recruitment of substrate-specificity properties from one enzyme into a related one by protein engineering Proceedings of the National Academy of Sciences of the United States of America. 84: 5167-5171. PMID 3299378 DOI: 10.1073/Pnas.84.15.5167  1
1986 Power SD, Adams RM, Wells JA. Secretion and autoproteolytic maturation of subtilisin. Proceedings of the National Academy of Sciences of the United States of America. 83: 3096-100. PMID 3517850 DOI: 10.1073/Pnas.83.10.3096  1
1985 Nakamaye KL, Wells JA, Bridenbaugh RL, Okamoto Y, Yount RG. 2-[(4-Azido-2-nitrophenyl)amino]ethyl triphosphate, a novel chromophoric and photoaffinity analogue of ATP. Synthesis, characterization, and interaction with myosin subfragment 1. Biochemistry. 24: 5226-35. PMID 4074691 DOI: 10.1021/Bi00340A041  1
1985 Wells JA, Vasser M, Powers DB. Cassette mutagenesis: an efficient method for generation of multiple mutations at defined sites Gene. 34: 315-323. PMID 3891521 DOI: 10.1016/0378-1119(85)90140-4  1
1984 Perkins WJ, Wells JA, Yount RG. Characterization of the properties of ethenoadenosine nucleotides bound or trapped at the active site of myosin subfragment 1. Biochemistry. 23: 3994-4002. PMID 6237680 DOI: 10.1021/Bi00312A029  1
1983 Dalbey RE, Wells JA, Yount RG. Trapping of transition metal-nucleotide complexes in myosin subfragment 1 by cross-linking thiols; divalent transition metal probes of the active site. Biochemistry. 22: 490-6. PMID 6824640 DOI: 10.1021/Bi00271A036  1
1983 Wells JA, Ferrari E, Henner DJ, Estell DA, Chen EY. Cloning, sequencing, and secretion of bacillus amyloliquefaciens subtillisin in Bacillus subtilis Nucleic Acids Research. 11: 7911-7925. DOI: 10.1093/Nar/11.22.7911  1
1982 Wells JA, Yount RG. Chemical modification of myosin by active-site trapping of metal-nucleotides with thiol crosslinking reagents. Methods in Enzymology. 85: 93-116. PMID 7121292 DOI: 10.1016/0076-6879(82)85013-1  1
1980 Wells JA, Knoeber C, Sheldon MC, Werber MM, Yount RG. Cross-linking of myosin subfragment 1. Nucleotide-enhanced modification by a variety of bifunctional reagents. The Journal of Biological Chemistry. 255: 11135-40. PMID 7440533  1
1980 Wells JA, Werber MM, Yount RG. Mechanism of inactivation of myosin subfragment 1 by Co(III)phenATP. A reinvestigation. The Journal of Biological Chemistry. 255: 7552-5. PMID 6447149  1
1980 Wells JA, Yount RG. Reaction of 5,5'-dithiobis(2-nitrobenzoic acid) with myosin subfragment one: evidence for formation of a single protein disulfide with trapping of metal nucleotide at the active site. Biochemistry. 19: 1711-7. PMID 6445748 DOI: 10.1021/Bi00549A030  1
1980 Wells JA, Sheldon M, Yount RG. Magnesium nucleotide is stoichiometrically trapped at the active site of myosin and its active proteolytic fragments by thiol cross-linking reagents. The Journal of Biological Chemistry. 255: 1598-602. PMID 6444414  1
1979 Wells JA, Werber MM, Yount RG. Inactivation of myosin subfragment one by cobalt(II)/cobalt(III) phenanthroline complexes. 2. Cobalt chelation of two critical SH groups. Biochemistry. 18: 4800-5. PMID 159719 DOI: 10.1021/Bi00589A006  1
1979 Wells JA, Yount RG. Active site trapping of nucleotides by crosslinking two sulfhydryls in myosin subfragment 1. Proceedings of the National Academy of Sciences of the United States of America. 76: 4966-70. PMID 159451 DOI: 10.1073/Pnas.76.10.4966  1
1979 Wells JA, Werber MM, Legg JI, Yount RG. Inactivation of myosin subfragment one by cobalt(II)/cobalt(III) phenanthroline complexes. I. Incorporation of Co(III) by in situ oxidation of Co(II). Biochemistry. 18: 4793-9. PMID 41570  1
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