Craig M. Crews, Ph.D. - Publications

Affiliations: 
Molecular, Cellular & Developmental Biology Yale University, New Haven, CT 
Area:
organic synthesis, pharmacology, molecular biology
Website:
http://crewslab.yale.edu/

141 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Burslem GM, Schultz AR, Bondeson DP, Eide CA, Savage Stevens SL, Druker BJ, Crews CM. Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-mediated Targeted Protein Degradation. Cancer Research. PMID 31311809 DOI: 10.1158/0008-5472.CAN-19-1236  0.64
2019 Hellerschmied D, Serebrenik YV, Shao L, Burslem GM, Crews CM. Protein Folding State-dependent Sorting at the Golgi Apparatus. Molecular Biology of the Cell. mbcE19010069. PMID 31166830 DOI: 10.1091/mbc.E19-01-0069  0.64
2019 Smith BE, Wang SL, Jaime-Figueroa S, Harbin A, Wang J, Hamman BD, Crews CM. Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase. Nature Communications. 10: 131. PMID 30631068 DOI: 10.1038/s41467-018-08027-7  0.64
2018 Cromm PM, Samarasinghe K, Hines J, Crews CM. Addressing Kinase-Independent Functions of Fak via PROTAC-mediated Degradation. Journal of the American Chemical Society. PMID 30444612 DOI: 10.1021/jacs.8b08008  0.48
2018 Burslem GM, Song J, Chen X, Hines J, Crews CM. Enhancing Anti-Proliferative Activity and Selectivity of a FLT-3 Inhibitor by PROTAC Conversion. Journal of the American Chemical Society. PMID 30427680 DOI: 10.1021/jacs.8b10320  0.64
2018 Hines J, Lartigue S, Dong H, Qian Y, Crews CM. MDM2-recruiting PROTAC Offers Superior, Synergistic Anti-proliferative Activity via Simultaneous Degradation of BRD4 and Stabilization of p53. Cancer Research. PMID 30385614 DOI: 10.1158/0008-5472.CAN-18-2918  0.48
2018 Burslem GM, Ottis P, Jaime-Figueroa S, Morgan A, Cromm P, Toure M, Crews C. Efficient Synthesis of Immunomodulatory Drug Analogues Enables Exploration of Structure Degradation Relationships. Chemmedchem. PMID 29870139 DOI: 10.1002/cmdc.201800271  1
2018 Serebrenik YV, Hellerschmied D, Toure M, López-Giráldez F, Brookner D, Crews CM. Targeted protein unfolding uncovers a Golgi-specific transcriptional stress response. Molecular Biology of the Cell. 29: 1284-1298. PMID 29851555 DOI: 10.1091/mbc.E17-11-0693  0.68
2018 Buhimschi AD, Armstrong HA, Toure M, Jaime-Figueroa S, Chen TL, Lehman AM, Woyach JA, Johnson AJ, Byrd JC, Crews CM. Targeting the C481S Ibrutinib-Resistance Mutation in Bruton's Tyrosine Kinase using PROTAC-mediated Degradation. Biochemistry. PMID 29851337 DOI: 10.1021/acs.biochem.8b00391  0.68
2018 Flowers GP, Crews CM. Regeneration writ large. Nature. 554: 34-35. PMID 29388980 DOI: 10.1038/d41586-017-09008-4  1
2017 Bondeson DP, Smith BE, Burslem GM, Buhimschi AD, Hines J, Jaime-Figueroa S, Wang J, Hamman BD, Ishchenko A, Crews CM. Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead. Cell Chemical Biology. PMID 29129718 DOI: 10.1016/j.chembiol.2017.09.010  0.64
2017 Burslem GM, Smith BE, Lai AC, Jaime-Figueroa S, McQuaid DC, Bondeson DP, Toure M, Dong H, Qian Y, Wang J, Crew AP, Hines J, Crews CM. The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study. Cell Chemical Biology. PMID 29129716 DOI: 10.1016/j.chembiol.2017.09.009  0.68
2017 Flowers GP, Sanor LD, Crews CM. Lineage tracing of genome-edited alleles reveals high fidelity axolotl limb regeneration. Elife. 6. PMID 28917058 DOI: 10.7554/eLife.25726  1
2017 Cromm PM, Crews CM. The Proteasome in Modern Drug Discovery: Second Life of a Highly Valuable Drug Target. Acs Central Science. 3: 830-838. PMID 28852696 DOI: 10.1021/acscentsci.7b00252  0.36
2017 Burslem GM, Crews CM. Small-Molecule Modulation of Protein Homeostasis. Chemical Reviews. PMID 28777566 DOI: 10.1021/acs.chemrev.7b00077  0.64
2017 Ottis P, Toure M, Cromm PM, Ko E, Gustafson JL, Crews CM. Assessing Different E3 Ligases for Small Molecule-induced Protein Ubiquitination and Degradation. Acs Chemical Biology. PMID 28767222 DOI: 10.1021/acschembio.7b00485  1
2017 Crew AP, Raina K, Dong H, Qian Y, Wang J, Vigil D, Serebrenik YV, Hamman BD, Morgan A, Ferraro C, Siu K, Neklesa TK, Winkler JD, Coleman KG, Crews CM. Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1. Journal of Medicinal Chemistry. PMID 28692295 DOI: 10.1021/acs.jmedchem.7b00635  0.64
2017 Cromm PM, Crews CM. Targeted Protein Degradation: from Chemical Biology to Drug Discovery. Cell Chemical Biology. PMID 28648379 DOI: 10.1016/j.chembiol.2017.05.024  0.36
2017 Ottis P, Crews CM. PROTACs: Induced Protein Degradation as a Therapeutic Strategy. Acs Chemical Biology. PMID 28263557 DOI: 10.1021/acschembio.6b01068  1
2016 Toure M, Jaime-Figueroa S, Burslem GM, Crews CM. Expeditious Synthesis of Isoquinolones and Isocoumarins with a Vinyl Borane as an Acetylene Equivalent. European Journal of Organic Chemistry. 2016: 4171-4175. PMID 28781577 DOI: 10.1002/ejoc.201600575  0.68
2016 Raina K, Lu J, Qian Y, Altieri M, Gordon D, Rossi AM, Wang J, Chen X, Dong H, Siu K, Winkler JD, Crew AP, Crews CM, Coleman KG. PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer. Proceedings of the National Academy of Sciences of the United States of America. PMID 27274052 DOI: 10.1073/pnas.1521738113  1
2016 Al-Obaidi N, Mitchison TJ, Crews CM, Mayer TU. Identification of MAC1: A Small Molecule That Rescues Spindle Bipolarity in Monastrol-Treated Cells. Acs Chemical Biology. PMID 27121275 DOI: 10.1021/acschembio.6b00203  1
2016 Toure M, Crews CM. Small-Molecule PROTACS: New Approaches to Protein Degradation. Angewandte Chemie (International Ed. in English). PMID 26756721 DOI: 10.1002/anie.201507978  1
2015 Lai AC, Toure M, Hellerschmied D, Salami J, Jaime-Figueroa S, Ko E, Hines J, Crews CM. Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL. Angewandte Chemie (International Ed. in English). PMID 26593377 DOI: 10.1002/anie.201507634  1
2015 Lim SM, Xie T, Westover KD, Ficarro SB, Tae HS, Gurbani D, Sim T, Marto JA, Jänne PA, Crews CM, Gray NS. Development of small molecules targeting the pseudokinase Her3. Bioorganic & Medicinal Chemistry Letters. 25: 3382-9. PMID 26094118 DOI: 10.1016/j.bmcl.2015.04.103  1
2015 Gustafson JL, Neklesa TK, Cox CS, Roth AG, Buckley DL, Tae HS, Sundberg TB, Stagg DB, Hines J, McDonnell DP, Norris JD, Crews CM. Small-Molecule-Mediated Degradation of the Androgen Receptor Through Hydrophobic Tagging. Angewandte Chemie (International Ed. in English). PMID 26083457 DOI: 10.1002/anie.201503720  1
2015 Bondeson DP, Mares A, Smith IE, Ko E, Campos S, Miah AH, Mulholland KE, Routly N, Buckley DL, Gustafson JL, Zinn N, Grandi P, Shimamura S, Bergamini G, Faelth-Savitski M, ... ... Crews CM, et al. Catalytic in vivo protein knockdown by small-molecule PROTACs. Nature Chemical Biology. 11: 611-7. PMID 26075522 DOI: 10.1038/nchembio.1858  1
2015 Buckley DL, Raina K, Darricarrere N, Hines J, Gustafson JL, Smith IE, Miah AH, Harling JD, Crews CM. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins. Acs Chemical Biology. PMID 26070106 DOI: 10.1021/acschembio.5b00442  1
2015 Lu J, Qian Y, Altieri M, Dong H, Wang J, Raina K, Hines J, Winkler JD, Crew AP, Coleman K, Crews CM. Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4. Chemistry & Biology. 22: 755-63. PMID 26051217 DOI: 10.1016/j.chembiol.2015.05.009  1
2015 Flowers GP, Crews CM. Generating and identifying axolotls with targeted mutations using Cas9 RNA-guided nuclease. Methods in Molecular Biology (Clifton, N.J.). 1290: 279-95. PMID 25740494 DOI: 10.1007/978-1-4939-2495-0_22  1
2014 Xie T, Lim SM, Westover KD, Dodge ME, Ercan D, Ficarro SB, Udayakumar D, Gurbani D, Tae HS, Riddle SM, Sim T, Marto JA, Jänne PA, Crews CM, Gray NS. Pharmacological targeting of the pseudokinase Her3. Nature Chemical Biology. 10: 1006-12. PMID 25326665 DOI: 10.1038/nchembio.1658  1
2014 Raina K, Noblin DJ, Serebrenik YV, Adams A, Zhao C, Crews CM. Targeted protein destabilization reveals an estrogen-mediated ER stress response. Nature Chemical Biology. 10: 957-62. PMID 25242550 DOI: 10.1038/nchembio.1638  1
2014 Crews C, Hertweck C, Shokat K, Suga H, Kostic M. Reflecting on the past and looking forward to the future of bridging chemistry and biology. Chemistry & Biology. 21: 1035-6. PMID 25237850 DOI: 10.1016/j.chembiol.2014.09.004  1
2014 Flowers GP, Timberlake AT, McLean KC, Monaghan JR, Crews CM. Highly efficient targeted mutagenesis in axolotl using Cas9 RNA-guided nuclease. Development (Cambridge, England). 141: 2165-71. PMID 24764077 DOI: 10.1242/dev.105072  1
2014 Buckley DL, Crews CM. Small-molecule control of intracellular protein levels through modulation of the ubiquitin proteasome system. Angewandte Chemie (International Ed. in English). 53: 2312-30. PMID 24459094 DOI: 10.1002/anie.201307761  1
2013 Neklesa TK, Noblin DJ, Kuzin A, Lew S, Seetharaman J, Acton TB, Kornhaber G, Xiao R, Montelione GT, Tong L, Crews CM. A bidirectional system for the dynamic small molecule control of intracellular fusion proteins. Acs Chemical Biology. 8: 2293-300. PMID 23978068 DOI: 10.1021/cb400569k  1
2013 Hines J, Gough JD, Corson TW, Crews CM. Posttranslational protein knockdown coupled to receptor tyrosine kinase activation with phosphoPROTACs. Proceedings of the National Academy of Sciences of the United States of America. 110: 8942-7. PMID 23674677 DOI: 10.1073/pnas.1217206110  1
2013 Kim KB, Crews CM. From epoxomicin to carfilzomib: chemistry, biology, and medical outcomes. Natural Product Reports. 30: 600-4. PMID 23575525 DOI: 10.1039/c3np20126k  1
2012 Crews C, Shokat K, Suga H, Kostic M. News from the Chemistry & Biology editorial team. Chemistry & Biology. 19: 1355. PMID 23177188 DOI: 10.1016/j.chembiol.2012.11.003  1
2012 Van Molle I, Thomann A, Buckley DL, So EC, Lang S, Crews CM, Ciulli A. Dissecting fragment-based lead discovery at the von Hippel-Lindau protein:hypoxia inducible factor 1α protein-protein interface. Chemistry & Biology. 19: 1300-12. PMID 23102223 DOI: 10.1016/j.chembiol.2012.08.015  1
2012 Buckley DL, Gustafson JL, Van Molle I, Roth AG, Tae HS, Gareiss PC, Jorgensen WL, Ciulli A, Crews CM. Small-molecule inhibitors of the interaction between the E3 ligase VHL and HIF1α. Angewandte Chemie (International Ed. in English). 51: 11463-7. PMID 23065727 DOI: 10.1002/anie.201206231  1
2012 Holman EC, Campbell LJ, Hines J, Crews CM. Microarray analysis of microRNA expression during axolotl limb regeneration. Plos One. 7: e41804. PMID 23028429 DOI: 10.1371/journal.pone.0041804  1
2012 Noblin DJ, Page CM, Tae HS, Gareiss PC, Schneekloth JS, Crews CM. A HaloTag-based small molecule microarray screening methodology with increased sensitivity and multiplex capabilities. Acs Chemical Biology. 7: 2055-63. PMID 23013033 DOI: 10.1021/cb300453k  1
2012 Neklesa TK, Crews CM. Chemical biology: Greasy tags for protein removal. Nature. 487: 308-9. PMID 22810693 DOI: 10.1038/487308a  1
2012 Buckley DL, Van Molle I, Gareiss PC, Tae HS, Michel J, Noblin DJ, Jorgensen WL, Ciulli A, Crews CM. Targeting the von Hippel-Lindau E3 ubiquitin ligase using small molecules to disrupt the VHL/HIF-1α interaction. Journal of the American Chemical Society. 134: 4465-8. PMID 22369643 DOI: 10.1021/ja209924v  1
2012 Tae HS, Sundberg TB, Neklesa TK, Noblin DJ, Gustafson JL, Roth AG, Raina K, Crews CM. Identification of hydrophobic tags for the degradation of stabilized proteins. Chembiochem : a European Journal of Chemical Biology. 13: 538-41. PMID 22271667 DOI: 10.1002/cbic.201100793  1
2012 Aberle N, Crews CM. Exploring biology with small organic molecules Chemical Genomics. 10-25. DOI: 10.1017/CBO9781139021500.004  1
2011 Sundberg TB, Darricarrere N, Cirone P, Li X, McDonald L, Mei X, Westlake CJ, Slusarski DC, Beynon RJ, Crews CM. Disruption of Wnt planar cell polarity signaling by aberrant accumulation of the MetAP-2 substrate Rab37. Chemistry & Biology. 18: 1300-11. PMID 22035799 DOI: 10.1016/j.chembiol.2011.07.020  1
2011 Neklesa TK, Tae HS, Schneekloth AR, Stulberg MJ, Corson TW, Sundberg TB, Raina K, Holley SA, Crews CM. Small-molecule hydrophobic tagging-induced degradation of HaloTag fusion proteins. Nature Chemical Biology. 7: 538-43. PMID 21725302 DOI: 10.1038/nchembio.597  1
2011 Fedeles SV, Tian X, Gallagher AR, Mitobe M, Nishio S, Lee SH, Cai Y, Geng L, Crews CM, Somlo S. A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation. Nature Genetics. 43: 639-47. PMID 21685914 DOI: 10.1038/ng.860  1
2011 Corson TW, Cavga H, Aberle N, Crews CM. Triptolide directly inhibits dCTP pyrophosphatase. Chembiochem : a European Journal of Chemical Biology. 12: 1767-73. PMID 21671327 DOI: 10.1002/cbic.201100007  1
2011 Campbell LJ, Suárez-Castillo EC, Ortiz-Zuazaga H, Knapp D, Tanaka EM, Crews CM. Gene expression profile of the regeneration epithelium during axolotl limb regeneration. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 240: 1826-40. PMID 21648017 DOI: 10.1002/dvdy.22669  1
2011 Schneekloth JS, Crews CM. Natural product inhibitors of the ubiquitin-proteasome pathway. Current Drug Targets. 12: 1581-94. PMID 21561423 DOI: 10.2174/138945011798109491  1
2011 Crews C, Shokat K, Wohlleben W, Kostic M. Chemistry & Biology editors announce changes to the editorial team. Chemistry & Biology. 18: 141. PMID 21338910 DOI: 10.1016/j.chembiol.2011.02.004  1
2011 Tae HS, Hines J, Schneekloth AR, Crews CM. Unexpected stereochemical tolerance for the biological activity of tyroscherin. Bioorganic & Medicinal Chemistry. 19: 1708-13. PMID 21315614 DOI: 10.1016/j.bmc.2011.01.027  1
2011 Buckley DL, Corson TW, Aberle N, Crews CM. HIV protease-mediated activation of sterically capped proteasome inhibitors and substrates. Journal of the American Chemical Society. 133: 698-700. PMID 21186803 DOI: 10.1021/ja109377p  1
2010 Tae HS, Hines J, Schneekloth AR, Crews CM. Total synthesis and biological evaluation of tyroscherin. Organic Letters. 12: 4308-11. PMID 20831175 DOI: 10.1021/ol101801u  1
2010 Crews CM. Targeting the undruggable proteome: the small molecules of my dreams. Chemistry & Biology. 17: 551-5. PMID 20609404 DOI: 10.1016/j.chembiol.2010.05.011  1
2010 Hines J, Ju R, Dutschman GE, Cheng YC, Crews CM. Reversal of TNP-470-induced endothelial cell growth arrest by guanine and guanine nucleosides. The Journal of Pharmacology and Experimental Therapeutics. 334: 729-38. PMID 20571059 DOI: 10.1124/jpet.110.169110  1
2010 Ju R, Cirone P, Lin S, Griesbach H, Slusarski DC, Crews CM. Activation of the planar cell polarity formin DAAM1 leads to inhibition of endothelial cell proliferation, migration, and angiogenesis. Proceedings of the National Academy of Sciences of the United States of America. 107: 6906-11. PMID 20351293 DOI: 10.1073/pnas.1001075107  1
2010 Raina K, Crews CM. Chemical inducers of targeted protein degradation. The Journal of Biological Chemistry. 285: 11057-60. PMID 20147751 DOI: 10.1074/jbc.R109.078105  1
2010 Leuenroth SJ, Bencivenga N, Chahboune H, Hyder F, Crews CM. Triptolide reduces cyst formation in a neonatal to adult transition Pkd1 model of ADPKD. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. 25: 2187-94. PMID 20139063 DOI: 10.1093/ndt/gfp777  1
2010 Gareiss PC, Schneekloth AR, Salcius MJ, Seo SY, Crews CM. Identification and characterization of a peptidic ligand for Ras. Chembiochem : a European Journal of Chemical Biology. 11: 517-22. PMID 20082398 DOI: 10.1002/cbic.200900547  1
2009 Custar DW, Zabawa TP, Hines J, Crews CM, Scheidt KA. Total synthesis and structure-activity investigation of the marine natural product neopeltolide. Journal of the American Chemical Society. 131: 12406-14. PMID 19663512 DOI: 10.1021/ja904604x  1
2009 Leuenroth SJ, Crews CM. Targeting cyst initiation in ADPKD. Journal of the American Society of Nephrology : Jasn. 20: 1-3. PMID 19118147 DOI: 10.1681/ASN.2008101118  1
2009 Crews C, Famulok M, Shokat K, Wohlleben W, Kostic M. Something Old, Something New Chemistry and Biology. 16: 909. DOI: 10.1016/j.chembiol.2009.09.007  1
2008 Corson TW, Aberle N, Crews CM. Design and Applications of Bifunctional Small Molecules: Why Two Heads Are Better Than One. Acs Chemical Biology. 3: 677-692. PMID 19112665 DOI: 10.1021/cb8001792  1
2008 Cirone P, Lin S, Griesbach HL, Zhang Y, Slusarski DC, Crews CM. A role for planar cell polarity signaling in angiogenesis. Angiogenesis. 11: 347-60. PMID 18798004 DOI: 10.1007/s10456-008-9116-2  1
2008 Rodriguez-Gonzalez A, Cyrus K, Salcius M, Kim K, Crews CM, Deshaies RJ, Sakamoto KM. Targeting steroid hormone receptors for ubiquitination and degradation in breast and prostate cancer. Oncogene. 27: 7201-11. PMID 18794799 DOI: 10.1038/onc.2008.320  1
2008 Schneekloth AR, Pucheault M, Tae HS, Crews CM. Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics. Bioorganic & Medicinal Chemistry Letters. 18: 5904-8. PMID 18752944 DOI: 10.1016/j.bmcl.2008.07.114  1
2008 Leuenroth SJ, Bencivenga N, Igarashi P, Somlo S, Crews CM. Triptolide reduces cystogenesis in a model of ADPKD. Journal of the American Society of Nephrology : Jasn. 19: 1659-62. PMID 18650476 DOI: 10.1681/ASN.2008030259  1
2008 Leuenroth SJ, Crews CM. Triptolide-induced transcriptional arrest is associated with changes in nuclear substructure. Cancer Research. 68: 5257-66. PMID 18593926 DOI: 10.1158/0008-5472.CAN-07-6207  1
2008 Hines J, Groll M, Fahnestock M, Crews CM. Proteasome inhibition by fellutamide B induces nerve growth factor synthesis. Chemistry & Biology. 15: 501-12. PMID 18482702 DOI: 10.1016/j.chembiol.2008.03.020  1
2008 Kim KB, Crews CM. Chemical genetics: exploring the role of the proteasome in cell biology using natural products and other small molecule proteasome inhibitors. Journal of Medicinal Chemistry. 51: 2600-5. PMID 18393403 DOI: 10.1021/jm070421s  1
2008 Campbell LJ, Crews CM. Wound epidermis formation and function in urodele amphibian limb regeneration. Cellular and Molecular Life Sciences : Cmls. 65: 73-9. PMID 18030417 DOI: 10.1007/s00018-007-7433-z  1
2008 Gough JD, Crews CM. Using Natural Products to Unravel Biological Mechanisms: Using Natural Products to Unravel Cell Biology Chemical Biology: From Small Molecules to Systems Biology and Drug Design, Volume 1-3. 1: 95-114. DOI: 10.1002/9783527619375.ch2b  1
2007 Corson TW, Crews CM. Molecular understanding and modern application of traditional medicines: triumphs and trials. Cell. 130: 769-74. PMID 17803898 DOI: 10.1016/j.cell.2007.08.021  1
2007 Petri AF, Schneekloth JS, Mandal AK, Crews CM. Synthesis of the C3-C18 fragment of amphidinolides G and H. Organic Letters. 9: 3001-4. PMID 17616200 DOI: 10.1021/ol071024e  1
2007 Leuenroth SJ, Okuhara D, Shotwell JD, Markowitz GS, Yu Z, Somlo S, Crews CM. Triptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney disease. Proceedings of the National Academy of Sciences of the United States of America. 104: 4389-94. PMID 17360534 DOI: 10.1073/pnas.0700499104  1
2007 Schneekloth JS, Pucheault M, Crews CM. Construction of highly substituted stereodefined dienes by cross-coupling of α-allenic acetates European Journal of Organic Chemistry. 40-43. DOI: 10.1002/ejoc.200600721  1
2006 Zhang Y, Yeh JR, Mara A, Ju R, Hines JF, Cirone P, Griesbach HL, Schneider I, Slusarski DC, Holley SA, Crews CM. A chemical and genetic approach to the mode of action of fumagillin. Chemistry & Biology. 13: 1001-9. PMID 16984890 DOI: 10.1016/j.chembiol.2006.07.010  1
2006 Hines J, Roy M, Cheng H, Agapakis CM, Taylor R, Crews CM. Myriaporone 3/4 structure--activity relationship studies define a pharmacophore targeting eukaryotic protein synthesis. Molecular Biosystems. 2: 371-9. PMID 16880957 DOI: 10.1039/b602936a  1
2006 Yeh JR, Ju R, Brdlik CM, Zhang W, Zhang Y, Matyskiela ME, Shotwell JD, Crews CM. Targeted gene disruption of methionine aminopeptidase 2 results in an embryonic gastrulation defect and endothelial cell growth arrest. Proceedings of the National Academy of Sciences of the United States of America. 103: 10379-84. PMID 16790550 DOI: 10.1073/pnas.0511313103  1
2006 Gough JD, Crews CM. Probing protein function with small molecules. Ernst Schering Research Foundation Workshop. 61-74. PMID 16708999  1
2006 Schneekloth JS, Sanders JL, Hines J, Crews CM. Neurotrophic peptide aldehydes: solid phase synthesis of fellutamide B and a simplified analog. Bioorganic & Medicinal Chemistry Letters. 16: 3855-8. PMID 16697191 DOI: 10.1016/j.bmcl.2006.04.029  1
2006 Mandal AK, Schneekloth JS, Kuramochi K, Crews CM. Synthetic studies on amphidinolide B1. Organic Letters. 8: 427-30. PMID 16435851 DOI: 10.1021/ol052620g  1
2005 Leuenroth SJ, Crews CM. Studies on calcium dependence reveal multiple modes of action for triptolide. Chemistry & Biology. 12: 1259-68. PMID 16356843 DOI: 10.1016/j.chembiol.2005.09.009  1
2005 Bo Kim K, Fonseca FN, Crews CM. Development and characterization of proteasome inhibitors. Methods in Enzymology. 399: 585-609. PMID 16338383 DOI: 10.1016/S0076-6879(05)99039-3  1
2005 Mandal AK, Schneekloth JS, Crews CM. Stereoselective assembly of a 1,3-diene via coupling between an allenic acetate and a (B)-alkylborane: synthetic studies on amphidinolide B1. Organic Letters. 7: 3645-8. PMID 16092840 DOI: 10.1021/ol051175m  1
2005 Mandal AK, Hines J, Kuramochi K, Crews CM. Developing microcolin A analogs as biological probes. Bioorganic & Medicinal Chemistry Letters. 15: 4043-7. PMID 15993592 DOI: 10.1016/j.bmcl.2005.06.020  1
2005 Schneekloth JS, Crews CM. Chemical approaches to controlling intracellular protein degradation. Chembiochem : a European Journal of Chemical Biology. 6: 40-6. PMID 15532104 DOI: 10.1002/cbic.200400274  1
2004 Lin S, Yang ZQ, Kwok BH, Koldobskiy M, Crews CM, Danishefsky SJ. Total synthesis of TMC-95A and -B via a new reaction leading to Z-enamides. Some preliminary findings as to SAR. Journal of the American Chemical Society. 126: 6347-55. PMID 15149232 DOI: 10.1021/ja049821k  1
2004 Schneekloth JS, Fonseca FN, Koldobskiy M, Mandal A, Deshaies R, Sakamoto K, Crews CM. Chemical genetic control of protein levels: selective in vivo targeted degradation. Journal of the American Chemical Society. 126: 3748-54. PMID 15038727 DOI: 10.1021/ja039025z  1
2004 Brdlik CM, Crews CM. A single amino acid residue defines the difference in ovalicin sensitivity between type I and II methionine aminopeptidases. The Journal of Biological Chemistry. 279: 9475-80. PMID 14676204 DOI: 10.1074/jbc.M307246200  1
2003 Crews CM, Shotwell JB. Small-molecule inhibitors of the cell cycle: an overview. Progress in Cell Cycle Research. 5: 125-33. PMID 14593706  1
2003 Crews CM. Feeding the machine: mechanisms of proteasome-catalyzed degradation of ubiquitinated proteins. Current Opinion in Chemical Biology. 7: 534-9. PMID 14580555 DOI: 10.1016/j.cbpa.2003.08.002  1
2003 Sakamoto KM, Kim KB, Verma R, Ransick A, Stein B, Crews CM, Deshaies RJ. Development of Protacs to target cancer-promoting proteins for ubiquitination and degradation. Molecular & Cellular Proteomics : McP. 2: 1350-8. PMID 14525958 DOI: 10.1074/mcp.T300009-MCP200  1
2003 Yeh JR, Crews CM. Chemical genetics: adding to the developmental biology toolbox. Developmental Cell. 5: 11-9. PMID 12852848 DOI: 10.1016/S1534-5807(03)00200-4  1
2003 Yang ZQ, Kwok BH, Lin S, Koldobskiy MA, Crews CM, Danishefsky SJ. Simplified synthetic TMC-95A/B analogues retain the potency of proteasome inhibitory activity. Chembiochem : a European Journal of Chemical Biology. 4: 508-13. PMID 12794861 DOI: 10.1002/cbic.200300560  1
2003 Garrett IR, Chen D, Gutierrez G, Zhao M, Escobedo A, Rossini G, Harris SE, Gallwitz W, Kim KB, Hu S, Crews CM, Mundy GR. Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro. The Journal of Clinical Investigation. 111: 1771-82. PMID 12782679 DOI: 10.1172/JCI16198  1
2002 Koh B, Crews CM. Chemical genetics: a small molecule approach to neurobiology. Neuron. 36: 563-6. PMID 12441047 DOI: 10.1016/S0896-6273(02)01059-0  1
2002 Shotwell JB, Koh B, Choi HW, Wood JL, Crews CM. Inhibitors of NF-kappaB signaling: design and synthesis of a biotinylated isopanepoxydone affinity reagent. Bioorganic & Medicinal Chemistry Letters. 12: 3463-6. PMID 12419384 DOI: 10.1016/S0960-894X(02)00769-2  1
2002 Shotwell JB, Krygowski ES, Hines J, Koh B, Huntsman EW, Choi HW, Schneekloth JS, Wood JL, Crews CM. Total synthesis of luminacin D. Organic Letters. 4: 3087-9. PMID 12201723 DOI: 10.1021/ol026382q  1
2002 Ndubuisil MI, Kwok BH, Vervoort J, Koh BD, Elofsson M, Crews CM. Characterization of a novel mammalian phosphatase having sequence similarity to Schizosaccharomyces pombe PHO2 and Saccharomyces cerevisiae PHO13. Biochemistry. 41: 7841-8. PMID 12056916 DOI: 10.1021/bi0255064  1
2001 Kwok BH, Koh B, Ndubuisi MI, Elofsson M, Crews CM. The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase. Chemistry & Biology. 8: 759-66. PMID 11514225 DOI: 10.1016/S1074-5521(01)00049-7  1
2001 Sakamoto KM, Kim KB, Kumagai A, Mercurio F, Crews CM, Deshaies RJ. Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation. Proceedings of the National Academy of Sciences of the United States of America. 98: 8554-9. PMID 11438690 DOI: 10.1073/pnas.141230798  1
2001 Myung J, Kim KB, Crews CM. The ubiquitin-proteasome pathway and proteasome inhibitors. Medicinal Research Reviews. 21: 245-73. PMID 11410931 DOI: 10.1002/med.1009  1
2001 Myung J, Kim KB, Lindsten K, Dantuma NP, Crews CM. Lack of proteasome active site allostery as revealed by subunit-specific inhibitors. Molecular Cell. 7: 411-20. PMID 11239469 DOI: 10.1016/S1097-2765(01)00188-5  1
2001 Princiotta MF, Schubert U, Chen W, Bennink JR, Myung J, Crews CM, Yewdell JW. Cells adapted to the proteasome inhibitor 4-hydroxy- 5-iodo-3-nitrophenylacetyl-Leu-Leu-leucinal-vinyl sulfone require enzymatically active proteasomes for continued survival. Proceedings of the National Academy of Sciences of the United States of America. 98: 513-8. PMID 11149939 DOI: 10.1073/pnas.021132398  1
2000 Yeh JR, Mohan R, Crews CM. The antiangiogenic agent TNP-470 requires p53 and p21CIP/WAF for endothelial cell growth arrest. Proceedings of the National Academy of Sciences of the United States of America. 97: 12782-7. PMID 11070090 DOI: 10.1073/pnas.97.23.12782  1
2000 Schwarz K, de Giuli R, Schmidtke G, Kostka S, van den Broek M, Kim KB, Crews CM, Kraft R, Groettrup M. The selective proteasome inhibitors lactacystin and epoxomicin can be used to either up- or down-regulate antigen presentation at nontoxic doses. Journal of Immunology (Baltimore, Md. : 1950). 164: 6147-57. PMID 10843664  1
2000 Crews CM, Mohan R. Small-molecule inhibitors of the cell cycle. Current Opinion in Chemical Biology. 4: 47-53. PMID 10679374 DOI: 10.1016/S1367-5931(99)00050-2  1
2000 Groll M, Kim KB, Kairies N, Huber R, Crews CM. Crystal structure of epoxomicin:20S proteasome reveals a molecular basis for selectivity of α',β'-epoxyketone proteasome inhibitors [12] Journal of the American Chemical Society. 122: 1237-1238. DOI: 10.1021/ja993588m  1
2000 Shotwell JB, Hu S, Medina E, Abe M, Cole R, Crews CM, Wood JL. Efficient stereoselective syntheses of isopanepoxydone and panepoxydone: A re-assignment of relative configuration Tetrahedron Letters. 41: 9639-9643.  1
1999 Kim KB, Myung J, Sin N, Crews CM. Proteasome inhibition by the natural products epoxomicin and dihydroeponemycin: insights into specificity and potency. Bioorganic & Medicinal Chemistry Letters. 9: 3335-40. PMID 10612595  1
1999 Elofsson M, Splittgerber U, Myung J, Mohan R, Crews CM. Towards subunit-specific proteasome inhibitors: synthesis and evaluation of peptide alpha',beta'-epoxyketones. Chemistry & Biology. 6: 811-22. PMID 10574782 DOI: 10.1016/S1074-5521(99)80128-8  1
1999 Meng L, Mohan R, Kwok BH, Elofsson M, Sin N, Crews CM. Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity. Proceedings of the National Academy of Sciences of the United States of America. 96: 10403-8. PMID 10468620 DOI: 10.1073/pnas.96.18.10403  1
1999 Sin N, Kim KB, Elofsson M, Meng L, Auth H, Kwok BH, Crews CM. Total synthesis of the potent proteasome inhibitor epoxomicin: a useful tool for understanding proteasome biology. Bioorganic & Medicinal Chemistry Letters. 9: 2283-8. PMID 10465562 DOI: 10.1016/S0960-894X(99)00376-5  1
1999 Crews CM, Splittgerber U. Chemical genetics: exploring and controlling cellular processes with chemical probes. Trends in Biochemical Sciences. 24: 317-20. PMID 10431176 DOI: 10.1016/S0968-0004(99)01425-5  1
1999 Meng L, Kwok BH, Sin N, Crews CM. Eponemycin exerts its antitumor effect through the inhibition of proteasome function. Cancer Research. 59: 2798-801. PMID 10383134  1
1998 Liu S, Widom J, Kemp CW, Crews CM, Clardy J. Structure of human methionine aminopeptidase-2 complexed with fumagillin. Science (New York, N.Y.). 282: 1324-7. PMID 9812898  1
1998 Sin N, Meng L, Auth H, Crews CM. Eponemycin analogues: syntheses and use as probes of angiogenesis. Bioorganic & Medicinal Chemistry. 6: 1209-17. PMID 9784862 DOI: 10.1016/S0968-0896(98)00089-3  1
1998 Meng L, Sin N, Crews CM. The antiproliferative agent didemnin B uncompetitively inhibits palmitoyl protein thioesterase. Biochemistry. 37: 10488-92. PMID 9671519 DOI: 10.1021/bi9804479  1
1998 Wen JJ, Crews CM. Synthesis of 9-fluorenylmethoxycarbonyl-protected amino aldehydes Tetrahedron Asymmetry. 9: 1855-1858. DOI: 10.1016/S0957-4166(98)00183-9  1
1998 Elofsson M, Crews CM. Tightening the nuts and bolts Trends in Biotechnology. 16: 147-149. DOI: 10.1016/S0167-7799(97)86280-4  1
1998 Wen JJ, Crews CM. Towards the semi-synthesis of didemnin M. solution and solid phase synthesis of the pseudotetrapeptide: pGlu-Glnψ[COO]Ala-Pro-OH Tetrahedron Letters. 39: 779-782. DOI: 10.1016/S0040-4039(97)10609-8  1
1997 Sin N, Meng L, Wang MQ, Wen JJ, Bornmann WG, Crews CM. The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2. Proceedings of the National Academy of Sciences of the United States of America. 94: 6099-103. PMID 9177176 DOI: 10.1073/pnas.94.12.6099  1
1996 Crews CM. Deciphering isozyme function: exploring cell biology with chemistry in the post-genomic era. Chemistry & Biology. 3: 961-5. PMID 9000005  1
1996 Crews CM, Lane WS, Schreiber SL. Didemnin binds to the protein palmitoyl thioesterase responsible for infantile neuronal ceroid lipofuscinosis. Proceedings of the National Academy of Sciences of the United States of America. 93: 4316-9. PMID 8633062 DOI: 10.1073/pnas.93.9.4316  1
1994 Crews CM, Collins JL, Lane WS, Snapper ML, Schreiber SL. GTP-dependent binding of the antiproliferative agent didemnin to elongation factor 1 alpha. The Journal of Biological Chemistry. 269: 15411-4. PMID 8195179  1
1993 Macdonald SG, Crews CM, Wu L, Driller J, Clark R, Erikson RL, McCormick F. Reconstitution of the Raf-1-MEK-ERK signal transduction pathway in vitro. Molecular and Cellular Biology. 13: 6615-20. PMID 8413257  1
1993 Crews CM, Erikson RL. Extracellular signals and reversible protein phosphorylation: what to Mek of it all. Cell. 74: 215-7. PMID 8343948 DOI: 10.1016/0092-8674(93)90411-I  1
1993 Brott BK, Alessandrini A, Largaespada DA, Copeland NG, Jenkins NA, Crews CM, Erikson RL. MEK2 is a kinase related to MEK1 and is differentially expressed in murine tissues. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 4: 921-9. PMID 8297798  1
1993 Huang W, Alessandrini A, Crews CM, Erikson RL. Raf-1 forms a stable complex with Mek1 and activates Mek1 by serine phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. 90: 10947-51. PMID 8248196  1
1992 Alessandrini A, Crews CM, Erikson RL. Phorbol ester stimulates a protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product. Proceedings of the National Academy of Sciences of the United States of America. 89: 8200-4. PMID 1518847  1
1992 Crews CM, Alessandrini A, Erikson RL. Erks: their fifteen minutes has arrived. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 3: 135-42. PMID 1504018  1
1992 Crews CM, Alessandrini A, Erikson RL. The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product. Science (New York, N.Y.). 258: 478-80. PMID 1411546  1
1992 Crews CM, Erikson RL. Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product. Proceedings of the National Academy of Sciences of the United States of America. 89: 8205-9. PMID 1381507  1
1992 Calvo V, Crews CM, Vik TA, Bierer BE. Interleukin 2 stimulation of p70 S6 kinase activity is inhibited by the immunosuppressant rapamycin. Proceedings of the National Academy of Sciences of the United States of America. 89: 7571-5. PMID 1380162  1
1991 Crews CM, Alessandrini AA, Erikson RL. Mouse Erk-1 gene product is a serine/threonine protein kinase that has the potential to phosphorylate tyrosine. Proceedings of the National Academy of Sciences of the United States of America. 88: 8845-9. PMID 1717989 DOI: 10.1073/pnas.88.19.8845  1
1989 Alcorta DA, Crews CM, Sweet LJ, Bankston L, Jones SW, Erikson RL. Sequence and expression of chicken and mouse rsk: homologs of Xenopus laevis ribosomal S6 kinase. Molecular and Cellular Biology. 9: 3850-9. PMID 2779569  1
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