Michael R. Williams - Publications
Affiliations: | 2011-2017 | Chemistry and Biochemistry | University of Arizona, Tucson, AZ |
Year | Citation | Score | |||
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2019 | Szatkowski L, Lynn ML, Holeman T, Williams MR, Baldo AP, Tardiff JC, Schwartz SD. Proof of Principle that Molecular Modeling Followed by a Biophysical Experiment Can Develop Small Molecules that Restore Function to the Cardiac Thin Filament in the Presence of Cardiomyopathic Mutations. Acs Omega. 4: 6492-6501. PMID 31342001 DOI: 10.1021/acsomega.8b03340 | 0.503 | |||
2018 | Williams MR, Tardiff JC, Schwartz SD. The Mechanism of Cardiac Tropomyosin Transitions on Filamentous Actin as Revealed by all Atom Steered Molecular Dynamics Simulations. The Journal of Physical Chemistry Letters. PMID 29863359 DOI: 10.1021/Acs.Jpclett.8B00958 | 0.488 | |||
2017 | McConnell M, Tal Grinspan L, Williams MR, Lynn ML, Schwartz BA, Fass OZ, Schwartz SD, Tardiff JC. Clinically Divergent Mutation Effects on the Structure and Function of the Human Cardiac Tropomyosin Overlap. Biochemistry. PMID 28603979 DOI: 10.1021/Acs.Biochem.7B00266 | 0.528 | |||
2016 | Williams MR, Lehman SJ, Tardiff JC, Schwartz SD. Atomic resolution probe for allostery in the regulatory thin filament. Proceedings of the National Academy of Sciences of the United States of America. PMID 26957598 DOI: 10.1073/Pnas.1519541113 | 0.558 | |||
2015 | Williams MR, Lehman SJ, Tardiff JC, Schwartz SD. An Explicitly Solvated Full Atomistic Model of the Cardiac Thin Filament and Application on the Calcium Binding Affinity Effects from Familial Hypertrophic Cardiomyopathy Linked Mutations Biophysical Journal. 108: 447a. DOI: 10.1016/J.Bpj.2014.11.2441 | 0.551 | |||
2014 | Williams MR, Tardiff J, Schwartz S. A Revised Atomistic Model of the Cardiac Thin Filament and Application to a Specific Disease Causing Mutation Biophysical Journal. 106: 32a. DOI: 10.1016/J.Bpj.2013.11.247 | 0.567 | |||
2014 | Jayasundar JJ, Brooks K, Lehman S, Williams MR, Tardiff JC. The Cardiac Troponin T R92L Hcm Mutation Alters Cardiac Troponin I Dynamics and PKA Phosphorylation Potential Biophysical Journal. 106: 348a. DOI: 10.1016/J.Bpj.2013.11.1983 | 0.422 | |||
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