Yechiel Shai - Publications

Biological Chemistry Weizmann Institute of Science, Rehovot, Israel 
Membrane Research and Biophysics

155 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Shmuel-Galia L, Aychek T, Fink A, Porat Z, Zarmi B, Bernshtein B, Brenner O, Jung S, Shai Y. Neutralization of pro-inflammatory monocytes by targeting TLR2 dimerization ameliorates colitis. The Embo Journal. PMID 26884587 DOI: 10.15252/embj.201592649  0.6
2016 Rotem E, Reuven EM, Klug YA, Shai Y. The transmembrane domain of HIV-1 gp41 inhibits T-cell activation by targeting multiple TCR complex components through its GxxxG-motif. Biochemistry. PMID 26828096 DOI: 10.1021/acs.biochem.5b01307  0.6
2015 Ghosh A, Bera S, Shai Y, Mangoni ML, Bhunia A. NMR structure and binding of esculentin-1a (1-21)NH2 and its diastereomer to lipopolysaccharide: Correlation with biological functions. Biochimica Et Biophysica Acta. PMID 26724203 DOI: 10.1016/j.bbamem.2015.12.027  0.6
2015 Sahl HG, Shai Y. Bacterial resistance to antimicrobial peptides. Biochimica Et Biophysica Acta. 1848: 3019-20. PMID 26342677 DOI: 10.1016/j.bbamem.2015.08.009  0.6
2015 Di Grazia A, Cappiello F, Cohen H, Casciaro B, Luca V, Pini A, Di YP, Shai Y, Mangoni ML. D-Amino acids incorporation in the frog skin-derived peptide esculentin-1a(1-21)NH2 is beneficial for its multiple functions. Amino Acids. PMID 26162435 DOI: 10.1007/s00726-015-2041-y  0.6
2015 Nuri R, Shprung T, Shai Y. Defensive remodeling: How bacterial surface properties and biofilm formation promote resistance to antimicrobial peptides. Biochimica Et Biophysica Acta. PMID 26051126 DOI: 10.1016/j.bbamem.2015.05.022  0.6
2015 Saar Dover R, Bitler A, Shimoni E, Trieu-Cuot P, Shai Y. Multiparametric AFM reveals turgor-responsive net-like peptidoglycan architecture in live streptococci. Nature Communications. 6: 7193. PMID 26018339 DOI: 10.1038/ncomms8193  0.6
2015 Segev-Zarko L, Saar-Dover R, Brumfeld V, Mangoni ML, Shai Y. Mechanisms of biofilm inhibition and degradation by antimicrobial peptides. The Biochemical Journal. 468: 259-70. PMID 25761937 DOI: 10.1042/BJ20141251  0.6
2014 Eckhard LH, Sol A, Abtew E, Shai Y, Domb AJ, Bachrach G, Beyth N. Biohybrid polymer-antimicrobial peptide medium against Enterococcus faecalis. Plos One. 9: e109413. PMID 25279943 DOI: 10.1371/journal.pone.0109413  0.6
2014 Reuven EM, Ali M, Rotem E, Schwarzter R, Gramatica A, Futerman AH, Shai Y. The HIV-1 envelope transmembrane domain binds TLR2 through a distinct dimerization motif and inhibits TLR2-mediated responses. Plos Pathogens. 10: e1004248. PMID 25121610 DOI: 10.1371/journal.ppat.1004248  0.6
2014 Sal-Man N, Gerber D, Shai Y. Proline localized to the interaction interface can mediate self-association of transmembrane domains. Biochimica Et Biophysica Acta. 1838: 2313-8. PMID 24841754 DOI: 10.1016/j.bbamem.2014.05.006  0.6
2014 Klug YA, Ashkenazi A, Viard M, Porat Z, Blumenthal R, Shai Y. Early and late HIV-1 membrane fusion events are impaired by sphinganine lipidated peptides that target the fusion site. The Biochemical Journal. 461: 213-22. PMID 24766462 DOI: 10.1042/BJ20140189  0.6
2014 Di Grazia A, Luca V, Segev-Zarko LA, Shai Y, Mangoni ML. Temporins A and B stimulate migration of HaCaT keratinocytes and kill intracellular Staphylococcus aureus. Antimicrobial Agents and Chemotherapy. 58: 2520-7. PMID 24514087 DOI: 10.1128/AAC.02801-13  0.6
2014 Reuven EM, Fink A, Shai Y. Regulation of innate immune responses by transmembrane interactions: lessons from the TLR family. Biochimica Et Biophysica Acta. 1838: 1586-93. PMID 24480409 DOI: 10.1016/j.bbamem.2014.01.020  0.6
2013 Faingold O, Ashkenazi A, Kaushansky N, Ben-Nun A, Shai Y. An immunomodulating motif of the HIV-1 fusion protein is chirality-independent: implications for its mode of action. The Journal of Biological Chemistry. 288: 32852-60. PMID 24078631 DOI: 10.1074/jbc.M113.512038  0.6
2013 Saar-Dover R, Ashkenazi A, Shai Y. Peptide interaction with and insertion into membranes. Methods in Molecular Biology (Clifton, N.J.). 1033: 173-83. PMID 23996178 DOI: 10.1007/978-1-62703-487-6_12  0.6
2013 Qiu J, Ashkenazi A, Liu S, Shai Y. Structural and functional properties of the membranotropic HIV-1 glycoprotein gp41 loop region are modulated by its intrinsic hydrophobic core. The Journal of Biological Chemistry. 288: 29143-50. PMID 23960077 DOI: 10.1074/jbc.M113.496646  0.6
2013 Ott M, Shai Y, Haran G. Single-particle tracking reveals switching of the HIV fusion peptide between two diffusive modes in membranes. The Journal of Physical Chemistry. B. 117: 13308-21. PMID 23915358 DOI: 10.1021/jp4039418  0.6
2013 Matalon E, Faingold O, Eisenstein M, Shai Y, Goldfarb D. The topology, in model membranes, of the core peptide derived from the T-cell receptor transmembrane domain. Chembiochem : a European Journal of Chemical Biology. 14: 1867-75. PMID 23881822 DOI: 10.1002/cbic.201300191  0.6
2013 Ashkenazi A, Faingold O, Shai Y. HIV-1 fusion protein exerts complex immunosuppressive effects. Trends in Biochemical Sciences. 38: 345-9. PMID 23685134 DOI: 10.1016/j.tibs.2013.04.003  0.6
2013 Fink A, Reuven EM, Arnusch CJ, Shmuel-Galia L, Antonovsky N, Shai Y. Assembly of the TLR2/6 transmembrane domains is essential for activation and is a target for prevention of sepsis. Journal of Immunology (Baltimore, Md. : 1950). 190: 6410-22. PMID 23677476 DOI: 10.4049/jimmunol.1202033  0.6
2013 Ashkenazi A, Faingold O, Kaushansky N, Ben-Nun A, Shai Y. A highly conserved sequence associated with the HIV gp41 loop region is an immunomodulator of antigen-specific T cells in mice. Blood. 121: 2244-52. PMID 23325839 DOI: 10.1182/blood-2012-11-468900  0.6
2013 Matalon E, Kaminker I, Zimmermann H, Eisenstein M, Shai Y, Goldfarb D. Topology of the trans-membrane peptide WALP23 in model membranes under negative mismatch conditions. The Journal of Physical Chemistry. B. 117: 2280-93. PMID 23311473 DOI: 10.1021/jp310056h  0.6
2013 Shai Y. ATR-FTIR studies in pore forming and membrane induced fusion peptides. Biochimica Et Biophysica Acta. 1828: 2306-13. PMID 23201348 DOI: 10.1016/j.bbamem.2012.11.027  0.6
2013 Ashkenazi A, Shai Y. Viral Fusion Peptides Handbook of Biologically Active Peptides. 1904-1911. DOI: 10.1016/B978-0-12-385095-9.00260-8  0.6
2012 Saar-Dover R, Bitler A, Nezer R, Shmuel-Galia L, Firon A, Shimoni E, Trieu-Cuot P, Shai Y. D-alanylation of lipoteichoic acids confers resistance to cationic peptides in group B streptococcus by increasing the cell wall density. Plos Pathogens. 8: e1002891. PMID 22969424 DOI: 10.1371/journal.ppat.1002891  0.6
2012 Ulm H, Wilmes M, Shai Y, Sahl HG. Antimicrobial host defensins - specific antibiotic activities and innate defense modulation. Frontiers in Immunology. 3: 249. PMID 22912635 DOI: 10.3389/fimmu.2012.00249  0.6
2012 Ashkenazi A, Merklinger E, Shai Y. Intramolecular interactions within the human immunodeficiency virus-1 gp41 loop region and their involvement in lipid merging. Biochemistry. 51: 6981-9. PMID 22894130 DOI: 10.1021/bi300868f  0.6
2012 Ashkenazi A, Viard M, Unger L, Blumenthal R, Shai Y. Sphingopeptides: dihydrosphingosine-based fusion inhibitors against wild-type and enfuvirtide-resistant HIV-1. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 4628-36. PMID 22872679 DOI: 10.1096/fj.12-215111  0.6
2012 Faingold O, Cohen T, Shai Y. A GxxxG-like motif within HIV-1 fusion peptide is critical to its immunosuppressant activity, structure, and interaction with the transmembrane domain of the T-cell receptor. The Journal of Biological Chemistry. 287: 33503-11. PMID 22872636 DOI: 10.1074/jbc.M112.370817  0.6
2012 Bitler A, Dover R, Shai Y. Fractal properties of macrophage membrane studied by AFM. Micron (Oxford, England : 1993). 43: 1239-45. PMID 22633851 DOI: 10.1016/j.micron.2012.04.009  0.6
2012 Reuven EM, Dadon Y, Viard M, Manukovsky N, Blumenthal R, Shai Y. HIV-1 gp41 transmembrane domain interacts with the fusion peptide: implication in lipid mixing and inhibition of virus-cell fusion. Biochemistry. 51: 2867-78. PMID 22413880 DOI: 10.1021/bi201721r  0.6
2012 Arnusch CJ, Albada HB, van Vaardegem M, Liskamp RM, Sahl HG, Shadkchan Y, Osherov N, Shai Y. Trivalent ultrashort lipopeptides are potent pH dependent antifungal agents. Journal of Medicinal Chemistry. 55: 1296-302. PMID 22243686 DOI: 10.1021/jm2014474  0.6
2012 Shprung T, Peleg A, Rosenfeld Y, Trieu-Cuot P, Shai Y. Effect of PhoP-PhoQ activation by broad repertoire of antimicrobial peptides on bacterial resistance. The Journal of Biological Chemistry. 287: 4544-51. PMID 22158870 DOI: 10.1074/jbc.M111.278523  0.6
2012 Fink A, Sal-Man N, Gerber D, Shai Y. Transmembrane domains interactions within the membrane milieu: principles, advances and challenges. Biochimica Et Biophysica Acta. 1818: 974-83. PMID 22155642 DOI: 10.1016/j.bbamem.2011.11.029  0.6
2012 Merklinger E, Gofman Y, Kedrov A, Driessen AJ, Ben-Tal N, Shai Y, Rapaport D. Membrane integration of a mitochondrial signal-anchored protein does not require additional proteinaceous factors. The Biochemical Journal. 442: 381-9. PMID 22142226 DOI: 10.1042/BJ20111363  0.6
2012 Gordon-Grossman M, Zimmermann H, Wolf SG, Shai Y, Goldfarb D. Investigation of model membrane disruption mechanism by melittin using pulse electron paramagnetic resonance spectroscopy and cryogenic transmission electron microscopy. The Journal of Physical Chemistry. B. 116: 179-88. PMID 22091896 DOI: 10.1021/jp207159z  0.6
2012 Arnusch CJ, Ulm H, Josten M, Shadkchan Y, Osherov N, Sahl HG, Shai Y. Ultrashort peptide bioconjugates are exclusively antifungal agents and synergize with cyclodextrin and amphotericin B. Antimicrobial Agents and Chemotherapy. 56: 1-9. PMID 22006001 DOI: 10.1128/AAC.00468-11  0.6
2011 Al-Benna S, Shai Y, Jacobsen F, Steinstraesser L. Oncolytic activities of host defense peptides. International Journal of Molecular Sciences. 12: 8027-51. PMID 22174648 DOI: 10.3390/ijms12118027  0.6
2011 Ashkenazi A, Wexler-Cohen Y, Shai Y. Multifaceted action of Fuzeon as virus-cell membrane fusion inhibitor. Biochimica Et Biophysica Acta. 1808: 2352-8. PMID 21762676 DOI: 10.1016/j.bbamem.2011.06.020  0.6
2011 Mangoni ML, Shai Y. Short native antimicrobial peptides and engineered ultrashort lipopeptides: similarities and differences in cell specificities and modes of action. Cellular and Molecular Life Sciences : Cmls. 68: 2267-80. PMID 21573781 DOI: 10.1007/s00018-011-0718-2  0.6
2011 Gordon-Grossman M, Kaminker I, Gofman Y, Shai Y, Goldfarb D. W-Band pulse EPR distance measurements in peptides using Gd(3+)-dipicolinic acid derivatives as spin labels. Physical Chemistry Chemical Physics : Pccp. 13: 10771-80. PMID 21552622 DOI: 10.1039/c1cp00011j  0.6
2011 Papasergi S, Brega S, Mistou MY, Firon A, Oxaran V, Dover R, Teti G, Shai Y, Trieu-Cuot P, Dramsi S. The GBS PI-2a pilus is required for virulence in mice neonates. Plos One. 6: e18747. PMID 21525979 DOI: 10.1371/journal.pone.0018747  0.6
2011 Steinstraesser L, Hauk J, Schubert C, Al-Benna S, Stricker I, Hatt H, Shai Y, Steinau HU, Jacobsen F. Suppression of soft tissue sarcoma growth by a host defense-like lytic peptide. Plos One. 6: e18321. PMID 21483840 DOI: 10.1371/journal.pone.0018321  0.6
2011 Ashkenazi A, Viard M, Wexler-Cohen Y, Blumenthal R, Shai Y. Viral envelope protein folding and membrane hemifusion are enhanced by the conserved loop region of HIV-1 gp41. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 2156-66. PMID 21429941 DOI: 10.1096/fj.10-175752  0.6
2011 Ashkenazi A, Shai Y. Insights into the mechanism of HIV-1 envelope induced membrane fusion as revealed by its inhibitory peptides. European Biophysics Journal : Ebj. 40: 349-57. PMID 21258789 DOI: 10.1007/s00249-010-0666-z  0.6
2011 Steinstraesser L, Schubert C, Hauk J, Becerikli M, Stricker I, Koeller M, Hatt H, von Duering M, Shai Y, Steinau HU, Jacobsen F. Oncolytic designer host defense peptide suppresses growth of human liposarcoma. International Journal of Cancer. Journal International Du Cancer. 128: 2994-3004. PMID 20734391 DOI: 10.1002/ijc.25627  0.6
2010 Cohen T, Cohen SJ, Antonovsky N, Cohen IR, Shai Y. HIV-1 gp41 and TCRalpha trans-membrane domains share a motif exploited by the HIV virus to modulate T-cell proliferation. Plos Pathogens. 6: e1001085. PMID 20824090 DOI: 10.1371/journal.ppat.1001085  0.6
2010 Wexler-Cohen Y, Ashkenazi A, Viard M, Blumenthal R, Shai Y. Virus-cell and cell-cell fusion mediated by the HIV-1 envelope glycoprotein is inhibited by short gp41 N-terminal membrane-anchored peptides lacking the critical pocket domain. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 4196-202. PMID 20605950 DOI: 10.1096/fj.09-151704  0.6
2010 Kumar TA, Bardea A, Shai Y, Yoffe A, Naaman R. Patterning gradient properties from sub-micrometers to millimeters by magnetolithography. Nano Letters. 10: 2262-7. PMID 20491500 DOI: 10.1021/nl1013635  0.6
2010 Bitler A, Lev N, Fridmann-Sirkis Y, Blank L, Cohen SR, Shai Y. Kinetics of interaction of HIV fusion protein (gp41) with lipid membranes studied by real-time AFM imaging. Ultramicroscopy. 110: 694-700. PMID 20399563 DOI: 10.1016/j.ultramic.2010.02.034  0.6
2010 Epand RM, Epand RF, Arnusch CJ, Papahadjopoulos-Sternberg B, Wang G, Shai Y. Lipid clustering by three homologous arginine-rich antimicrobial peptides is insensitive to amino acid arrangement and induced secondary structure. Biochimica Et Biophysica Acta. 1798: 1272-80. PMID 20302840 DOI: 10.1016/j.bbamem.2010.03.012  0.6
2010 Sackett K, Nethercott MJ, Epand RF, Epand RM, Kindra DR, Shai Y, Weliky DP. Comparative analysis of membrane-associated fusion peptide secondary structure and lipid mixing function of HIV gp41 constructs that model the early pre-hairpin intermediate and final hairpin conformations. Journal of Molecular Biology. 397: 301-15. PMID 20080102 DOI: 10.1016/j.jmb.2010.01.018  0.6
2010 Rosenfeld Y, Lev N, Shai Y. Effect of the hydrophobicity to net positive charge ratio on antibacterial and anti-endotoxin activities of structurally similar antimicrobial peptides. Biochemistry. 49: 853-61. PMID 20058937 DOI: 10.1021/bi900724x  0.6
2009 Gordon-Grossman M, Gofman Y, Zimmermann H, Frydman V, Shai Y, Ben-Tal N, Goldfarb D. A combined pulse EPR and Monte Carlo simulation study provides molecular insight on peptide-membrane interactions. The Journal of Physical Chemistry. B. 113: 12687-95. PMID 19725508 DOI: 10.1021/jp905129b  0.6
2009 Wexler-Cohen Y, Shai Y. Membrane-anchored HIV-1 N-heptad repeat peptides are highly potent cell fusion inhibitors via an altered mode of action. Plos Pathogens. 5: e1000509. PMID 19593361 DOI: 10.1371/journal.ppat.1000509  0.6
2009 Brotman Y, Makovitzki A, Shai Y, Chet I, Viterbo A. Synthetic ultrashort cationic lipopeptides induce systemic plant defense responses against bacterial and fungal pathogens. Applied and Environmental Microbiology. 75: 5373-9. PMID 19542326 DOI: 10.1128/AEM.00724-09  0.6
2009 Chen L, Merzlyakov M, Cohen T, Shai Y, Hristova K. Energetics of ErbB1 transmembrane domain dimerization in lipid bilayers. Biophysical Journal. 96: 4622-30. PMID 19486684 DOI: 10.1016/j.bpj.2009.03.004  0.6
2009 Antcheva N, Morgera F, Creatti L, Vaccari L, Pag U, Pacor S, Shai Y, Sahl HG, Tossi A. Artificial beta-defensin based on a minimal defensin template. The Biochemical Journal. 421: 435-47. PMID 19453294 DOI: 10.1042/BJ20082242  0.6
2009 Mangoni ML, Shai Y. Temporins and their synergism against Gram-negative bacteria and in lipopolysaccharide detoxification. Biochimica Et Biophysica Acta. 1788: 1610-9. PMID 19422786 DOI: 10.1016/j.bbamem.2009.04.021  0.6
2009 Makovitzki A, Fink A, Shai Y. Suppression of human solid tumor growth in mice by intratumor and systemic inoculation of histidine-rich and pH-dependent host defense-like lytic peptides. Cancer Research. 69: 3458-63. PMID 19351852 DOI: 10.1158/0008-5472.CAN-08-3021  0.6
2009 Shai Y. Kinetics and thermodynamics of the microgene polymerization reaction. Biophysical Journal. 96: 1673-4. PMID 19254529 DOI: 10.1016/j.bpj.2008.11.010  0.6
2009 Sackett K, Nethercott MJ, Shai Y, Weliky DP. Hairpin folding of HIV gp41 abrogates lipid mixing function at physiologic pH and inhibits lipid mixing by exposed gp41 constructs. Biochemistry. 48: 2714-22. PMID 19222185 DOI: 10.1021/bi8019492  0.6
2009 Lev N, Fridmann-Sirkis Y, Blank L, Bitler A, Epand RF, Epand RM, Shai Y. Conformational stability and membrane interaction of the full-length ectodomain of HIV-1 gp41: implication for mode of action. Biochemistry. 48: 3166-75. PMID 19206186 DOI: 10.1021/bi802243j  0.6
2009 Klocek G, Schulthess T, Shai Y, Seelig J. Thermodynamics of melittin binding to lipid bilayers. Aggregation and pore formation. Biochemistry. 48: 2586-96. PMID 19173655 DOI: 10.1021/bi802127h  0.6
2008 Chou LC, Jang CY, Wu YH, Tsai WC, Wang SK, Chen J, Chang SC, Liu CC, Shai Y, Wen CR. Photon-exposure-dependent photon-stimulated desorption for obtaining photolysis cross section of molecules adsorbed on surface by monochromatic soft x-ray photons. The Journal of Chemical Physics. 129: 214104. PMID 19063541 DOI: 10.1063/1.3026598  0.6
2008 Makovitzki A, Baram J, Shai Y. Antimicrobial lipopolypeptides composed of palmitoyl Di- and tricationic peptides: in vitro and in vivo activities, self-assembly to nanostructures, and a plausible mode of action. Biochemistry. 47: 10630-6. PMID 18783248 DOI: 10.1021/bi8011675  0.6
2008 Vallon-Eberhard A, Makovitzki A, Beauvais A, Latgé JP, Jung S, Shai Y. Efficient clearance of Aspergillus fumigatus in murine lungs by an ultrashort antimicrobial lipopeptide, palmitoyl-lys-ala-DAla-lys. Antimicrobial Agents and Chemotherapy. 52: 3118-26. PMID 18606837 DOI: 10.1128/AAC.00526-08  0.6
2008 Mangoni ML, Epand RF, Rosenfeld Y, Peleg A, Barra D, Epand RM, Shai Y. Lipopolysaccharide, a key molecule involved in the synergism between temporins in inhibiting bacterial growth and in endotoxin neutralization. The Journal of Biological Chemistry. 283: 22907-17. PMID 18550541 DOI: 10.1074/jbc.M800495200  0.6
2008 Rosenfeld Y, Sahl HG, Shai Y. Parameters involved in antimicrobial and endotoxin detoxification activities of antimicrobial peptides. Biochemistry. 47: 6468-78. PMID 18498177 DOI: 10.1021/bi800450f  0.6
2008 Cohen T, Pevsner-Fischer M, Cohen N, Cohen IR, Shai Y. Characterization of the interacting domain of the HIV-1 fusion peptide with the transmembrane domain of the T-cell receptor. Biochemistry. 47: 4826-33. PMID 18376816 DOI: 10.1021/bi800100p  0.6
2008 Pag U, Oedenkoven M, Sass V, Shai Y, Shamova O, Antcheva N, Tossi A, Sahl HG. Analysis of in vitro activities and modes of action of synthetic antimicrobial peptides derived from an alpha-helical 'sequence template'. The Journal of Antimicrobial Chemotherapy. 61: 341-52. PMID 18174202 DOI: 10.1093/jac/dkm479  0.6
2007 Biggs JS, Rosenfeld Y, Shai Y, Olivera BM. Conolysin-Mt: a conus peptide that disrupts cellular membranes. Biochemistry. 46: 12586-93. PMID 17927208 DOI: 10.1021/bi700775p  0.6
2007 Lev N, Shai Y. Fatty acids can substitute the HIV fusion peptide in lipid merging and fusion: an analogy between viral and palmitoylated eukaryotic fusion proteins. Journal of Molecular Biology. 374: 220-30. PMID 17919659 DOI: 10.1016/j.jmb.2007.09.008  0.6
2007 Wen CR, Jang CY, Chou LC, Chen J, Wu YH, Chang SC, Tsai WC, Liu CC, Wang SK, Shai Y. Soft x-ray photoreactions of CF3Cl adsorbed on Si(111)-7x7 studied by continuous-time photon-stimulated desorption spectroscopy near F(1s) edge. The Journal of Chemical Physics. 127: 114704. PMID 17887867 DOI: 10.1063/1.2772257  0.6
2007 Makovitzki A, Viterbo A, Brotman Y, Chet I, Shai Y. Inhibition of fungal and bacterial plant pathogens in vitro and in planta with ultrashort cationic lipopeptides. Applied and Environmental Microbiology. 73: 6629-36. PMID 17720828 DOI: 10.1128/AEM.01334-07  0.6
2007 Wexler-Cohen Y, Shai Y. Demonstrating the C-terminal boundary of the HIV 1 fusion conformation in a dynamic ongoing fusion process and implication for fusion inhibition. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 3677-84. PMID 17575260 DOI: 10.1096/fj.07-8582com  0.6
2007 Huberman L, Gollop N, Mumcuoglu KY, Breuer E, Bhusare SR, Shai Y, Galun R. Antibacterial substances of low molecular weight isolated from the blowfly, Lucilia sericata. Medical and Veterinary Entomology. 21: 127-31. PMID 17550431 DOI: 10.1111/j.1365-2915.2007.00668.x  0.6
2007 Sal-Man N, Gerber D, Bloch I, Shai Y. Specificity in transmembrane helix-helix interactions mediated by aromatic residues. The Journal of Biological Chemistry. 282: 19753-61. PMID 17488729 DOI: 10.1074/jbc.M610368200  0.6
2007 Lorin A, Charloteaux B, Fridmann-Sirkis Y, Thomas A, Shai Y, Brasseur R. Mode of membrane interaction and fusogenic properties of a de novo transmembrane model peptide depend on the length of the hydrophobic core. The Journal of Biological Chemistry. 282: 18388-96. PMID 17459883 DOI: 10.1074/jbc.M700099200  0.6
2007 Quintana FJ, Gerber D, Bloch I, Cohen IR, Shai Y. A structurally altered D,L-amino acid TCRalpha transmembrane peptide interacts with the TCRalpha and inhibits T-cell activation in vitro and in an animal model. Biochemistry. 46: 2317-25. PMID 17288453 DOI: 10.1021/bi061849g  0.6
2007 Kristian SA, Timmer AM, Liu GY, Lauth X, Sal-Man N, Rosenfeld Y, Shai Y, Gallo RL, Nizet V. Impairment of innate immune killing mechanisms by bacteriostatic antibiotics. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 1107-16. PMID 17215486 DOI: 10.1096/fj.06-6802com  0.6
2007 Bloch I, Quintana FJ, Gerber D, Cohen T, Cohen IR, Shai Y. T-cell inactivation and immunosuppressive activity induced by HIV gp41 via novel interacting motif. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 393-401. PMID 17185749 DOI: 10.1096/fj.06-7061com  0.6
2007 Quintana FJ, Gerber D, Bloch I, Cohen IR, Shai Y. Response to "Interaction between HIV gp41 fusion peptide and T cell receptor: Putting the puzzle pieces back together" [2] Faseb Journal. 21: 1635. DOI: 10.1096/fj.07-0604ltr  0.6
2006 Shai Y, Makovitzky A, Avrahami D. Host defense peptides and lipopeptides: modes of action and potential candidates for the treatment of bacterial and fungal infections. Current Protein & Peptide Science. 7: 479-86. PMID 17168781 DOI: 10.2174/138920306779025620  0.6
2006 Korazim O, Sackett K, Shai Y. Functional and structural characterization of HIV-1 gp41 ectodomain regions in phospholipid membranes suggests that the fusion-active conformation is extended. Journal of Molecular Biology. 364: 1103-17. PMID 17045292 DOI: 10.1016/j.jmb.2006.08.091  0.6
2006 Makovitzki A, Avrahami D, Shai Y. Ultrashort antibacterial and antifungal lipopeptides. Proceedings of the National Academy of Sciences of the United States of America. 103: 15997-6002. PMID 17038500 DOI: 10.1073/pnas.0606129103  0.6
2006 Rosenfeld Y, Barra D, Simmaco M, Shai Y, Mangoni ML. A synergism between temporins toward Gram-negative bacteria overcomes resistance imposed by the lipopolysaccharide protective layer. The Journal of Biological Chemistry. 281: 28565-74. PMID 16867990 DOI: 10.1074/jbc.M606031200  0.6
2006 Rosenfeld Y, Shai Y. Lipopolysaccharide (Endotoxin)-host defense antibacterial peptides interactions: role in bacterial resistance and prevention of sepsis. Biochimica Et Biophysica Acta. 1758: 1513-22. PMID 16854372 DOI: 10.1016/j.bbamem.2006.05.017  0.6
2006 Sackett K, Wexler-Cohen Y, Shai Y. Characterization of the HIV N-terminal fusion peptide-containing region in context of key gp41 fusion conformations. The Journal of Biological Chemistry. 281: 21755-62. PMID 16751188 DOI: 10.1074/jbc.M603135200  0.6
2006 Papo N, Seger D, Makovitzki A, Kalchenko V, Eshhar Z, Degani H, Shai Y. Inhibition of tumor growth and elimination of multiple metastases in human prostate and breast xenografts by systemic inoculation of a host defense-like lytic peptide. Cancer Research. 66: 5371-8. PMID 16707464 DOI: 10.1158/0008-5472.CAN-05-4569  0.6
2006 Mangoni ML, Papo N, Saugar JM, Barra D, Shai Y, Simmaco M, Rivas L. Effect of natural L- to D-amino acid conversion on the organization, membrane binding, and biological function of the antimicrobial peptides bombinins H. Biochemistry. 45: 4266-76. PMID 16566601 DOI: 10.1021/bi052150y  0.6
2006 Wexler-Cohen Y, Johnson BT, Puri A, Blumenthal R, Shai Y. Structurally altered peptides reveal an important role for N-terminal heptad repeat binding and stability in the inhibitory action of HIV-1 peptide DP178. The Journal of Biological Chemistry. 281: 9005-10. PMID 16455666 DOI: 10.1074/jbc.M512475200  0.6
2006 Rosenfeld Y, Papo N, Shai Y. Endotoxin (lipopolysaccharide) neutralization by innate immunity host-defense peptides. Peptide properties and plausible modes of action. The Journal of Biological Chemistry. 281: 1636-43. PMID 16293630 DOI: 10.1074/jbc.M504327200  0.6
2006 Carmieli R, Papo N, Zimmermann H, Potapov A, Shai Y, Goldfarb D. Utilizing ESEEM spectroscopy to locate the position of specific regions of membrane-active peptides within model membranes. Biophysical Journal. 90: 492-505. PMID 16258052 DOI: 10.1529/biophysj.105.062992  0.6
2006 Tomasinsig L, Skerlavaj B, Papo N, Giabbai B, Shai Y, Zanetti M. Mechanistic and functional studies of the interaction of a proline-rich antimicrobial peptide with mammalian cells. The Journal of Biological Chemistry. 281: 383-91. PMID 16257969 DOI: 10.1074/jbc.M510354200  0.6
2006 Shai Y. Mechanism of Membrane Permeation and Pore Formation by Antimicrobial Peptides Protein-Lipid Interactions: From Membrane Domains to Cellular Networks. 187-217. DOI: 10.1002/3527606769.ch9  0.6
2005 Makovitzki A, Shai Y. pH-dependent antifungal lipopeptides and their plausible mode of action. Biochemistry. 44: 9775-84. PMID 16008362 DOI: 10.1021/bi0502386  0.6
2005 Quintana FJ, Gerber D, Kent SC, Cohen IR, Shai Y. HIV-1 fusion peptide targets the TCR and inhibits antigen-specific T cell activation. The Journal of Clinical Investigation. 115: 2149-58. PMID 16007266 DOI: 10.1172/JCI23956  0.6
2005 Sackett K, Shai Y. The HIV fusion peptide adopts intermolecular parallel beta-sheet structure in membranes when stabilized by the adjacent N-terminal heptad repeat: a 13C FTIR study. Journal of Molecular Biology. 350: 790-805. PMID 15964015 DOI: 10.1016/j.jmb.2005.05.030  0.6
2005 Sal-Man N, Gerber D, Shai Y. The identification of a minimal dimerization motif QXXS that enables homo- and hetero-association of transmembrane helices in vivo. The Journal of Biological Chemistry. 280: 27449-57. PMID 15911619 DOI: 10.1074/jbc.M503095200  0.6
2005 Malina A, Shai Y. Conjugation of fatty acids with different lengths modulates the antibacterial and antifungal activity of a cationic biologically inactive peptide. The Biochemical Journal. 390: 695-702. PMID 15907192 DOI: 10.1042/BJ20050520  0.6
2005 Papo N, Shai Y. Host defense peptides as new weapons in cancer treatment. Cellular and Molecular Life Sciences : Cmls. 62: 784-90. PMID 15868403 DOI: 10.1007/s00018-005-4560-2  0.6
2005 Gerber D, Quintana FJ, Bloch I, Cohen IR, Shai Y. D-enantiomer peptide of the TCRalpha transmembrane domain inhibits T-cell activation in vitro and in vivo. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 1190-2. PMID 15837719 DOI: 10.1096/fj.04-3498fje  0.6
2005 Zelezetsky I, Pacor S, Pag U, Papo N, Shai Y, Sahl HG, Tossi A. Controlled alteration of the shape and conformational stability of alpha-helical cell-lytic peptides: effect on mode of action and cell specificity. The Biochemical Journal. 390: 177-88. PMID 15836439 DOI: 10.1042/BJ20042138  0.6
2005 Wexler-Cohen Y, Sackett K, Shai Y. The role of the N-terminal heptad repeat of HIV-1 in the actual lipid mixing step as revealed by its substitution with distant coiled coils. Biochemistry. 44: 5853-61. PMID 15823044 DOI: 10.1021/bi047666g  0.6
2005 Papo N, Shai Y. A molecular mechanism for lipopolysaccharide protection of Gram-negative bacteria from antimicrobial peptides. The Journal of Biological Chemistry. 280: 10378-87. PMID 15632151 DOI: 10.1074/jbc.M412865200  0.6
2005 Sal-Man N, Shai Y. Arginine mutations within a transmembrane domain of Tar, an Escherichia coli aspartate receptor, can drive homodimer dissociation and heterodimer association in vivo. The Biochemical Journal. 385: 29-36. PMID 15330757 DOI: 10.1042/BJ20041022  0.6
2004 Sal-Man N, Gerber D, Shai Y. Hetero-assembly between all-L- and all-D-amino acid transmembrane domains: forces involved and implication for inactivation of membrane proteins. Journal of Molecular Biology. 344: 855-64. PMID 15533450 DOI: 10.1016/j.jmb.2004.09.066  0.6
2004 Gerber D, Pritsker M, Gunther-Ausborn S, Johnson B, Blumenthal R, Shai Y. Inhibition of HIV-1 envelope glycoprotein-mediated cell fusion by a DL-amino acid-containing fusion peptide: possible recognition of the fusion complex. The Journal of Biological Chemistry. 279: 48224-30. PMID 15339935 DOI: 10.1074/jbc.M403436200  0.6
2004 Papo N, Braunstein A, Eshhar Z, Shai Y. Suppression of human prostate tumor growth in mice by a cytolytic D-, L-amino Acid Peptide: membrane lysis, increased necrosis, and inhibition of prostate-specific antigen secretion. Cancer Research. 64: 5779-86. PMID 15313920 DOI: 10.1158/0008-5472.CAN-04-1438  0.6
2004 Braunstein A, Papo N, Shai Y. In vitro activity and potency of an intravenously injected antimicrobial peptide and its DL amino acid analog in mice infected with bacteria. Antimicrobial Agents and Chemotherapy. 48: 3127-9. PMID 15273131 DOI: 10.1128/AAC.48.8.3127-3129.2004  0.6
2004 Gallo SA, Sackett K, Rawat SS, Shai Y, Blumenthal R. The stability of the intact envelope glycoproteins is a major determinant of sensitivity of HIV/SIV to peptidic fusion inhibitors Journal of Molecular Biology. 340: 9-14. PMID 15184018 DOI: 10.1016/j.jmb.2004.04.027  0.6
2004 Papo N, Shai Y. Effect of drastic sequence alteration and D-amino acid incorporation on the membrane binding behavior of lytic peptides Biochemistry. 43: 6393-6403. PMID 15157073 DOI: 10.1021/bi049944h  0.6
2004 Gerber D, Sal-Man N, Shai Y. Structural adaptation of the glycophorin A transmembrane homodimer to D-amino acid modifications Journal of Molecular Biology. 339: 243-250. PMID 15123435 DOI: 10.1016/j.jmb.2004.03.004  0.6
2004 Gerber D, Sal-Man N, Shai Y. Two motifs within a transmembrane domain, one for homodimerization and the other for heterodimerization Journal of Biological Chemistry. 279: 21177-21182. PMID 14985340 DOI: 10.1074/jbc.M400847200  0.6
2004 Shnaper S, Sackett K, Gallo SA, Blumenthal R, Shai Y. The C- and the N-terminal Regions of Glycoprotein 41 Ectodomain Fuse Membranes Enriched and Not Enriched with Cholesterol, Respectively Journal of Biological Chemistry. 279: 18526-18534. PMID 14981088 DOI: 10.1074/jbc.M304950200  0.6
2004 Sal-Man N, Gerber D, Shai Y. The Composition Rather than Position of Polar Residues (QxxS) Drives Aspartate Receptor Transmembrane Domain Dimerization in Vivo Biochemistry. 43: 2309-2313. PMID 14979727 DOI: 10.1021/bi0356294  0.6
2004 Pag U, Oedenkoven M, Papo N, Oren Z, Shai Y, Sahl HG. In vitro activity and mode of action of diastereomeric antimicrobial peptides against bacterial clinical isolates Journal of Antimicrobial Chemotherapy. 53: 230-239. PMID 14729742 DOI: 10.1093/jac/dkh083  0.6
2004 Avrahami D, Shai Y. A New Group of Antifungal and Antibacterial Lipopeptides Derived from Non-membrane Active Peptides Conjugated to Palmitic Acid Journal of Biological Chemistry. 279: 12277-12285. PMID 14709550 DOI: 10.1074/jbc.M312260200  0.6
2003 Papo N, Shai Y. Can we predict biological activity of antimicrobial peptides from their interactions with model phospholipid membranes? Peptides. 24: 1693-1703. PMID 15019200 DOI: 10.1016/j.peptides.2003.09.013  0.6
2003 Avrahami D, Shai Y. Bestowing Antifungal and Antibacterial Activities by Lipophilic Acid Conjugation to D,L-Amino Acid-Containing Antimicrobial Peptides: A Plausible Mode of Action Biochemistry. 42: 14946-14956. PMID 14674771 DOI: 10.1021/bi035142v  0.6
2003 Mangoni ML, Papo N, Mignogna G, Andreu D, Shai Y, Barra D, Simmaco M. Ranacyclins, a New Family of Short Cyclic Antimicrobial Peptides: Biological Function, Mode of Action, and Parameters Involved in Target Specificity Biochemistry. 42: 14023-14035. PMID 14636071 DOI: 10.1021/bi034521l  0.6
2003 Peisajovich SG, Shai Y. Liposomes in Identification and Characterization of Viral Fusogenic Peptides Methods in Enzymology. 372: 361-373. PMID 14610824 DOI: 10.1016/S0076-6879(03)72021-7  0.6
2003 Sackett K, Shai Y. How structure correlates to function for membrane associated HIV-1 gp41 constructs corresponding to the N-terminal half of the ectodomain Journal of Molecular Biology. 333: 47-58. PMID 14516742 DOI: 10.1016/j.jmb.2003.07.008  0.6
2003 Papo N, Shai Y. New lytic peptides based on the D,L-amphipathic helix motif preferentially kill tumor cells compared to normal cells Biochemistry. 42: 9346-9354. PMID 12899621 DOI: 10.1021/bi027212o  0.6
2003 Peisajovich SG, Shai Y. Viral fusion proteins: Multiple regions contribute to membrane fusion Biochimica Et Biophysica Acta - Biomembranes. 1614: 122-129. PMID 12873773 DOI: 10.1016/S0005-2736(03)00170-6  0.6
2003 Papo N, Shahar M, Eisenbach L, Shai Y. A novel lytic peptide composed of DL-amino acids selectively kills cancer cells in culture and in mice Journal of Biological Chemistry. 278: 21018-21023. PMID 12646578 DOI: 10.1074/jbc.M211204200  0.6
2003 Peisajovich SG, Gallo SA, Blumenthal R, Shai Y. C-terminal octylation rescues an inactive T20 mutant. Implications for the mechanism of HIV/simian immunodeficiency virus-induced membrane fusion Journal of Biological Chemistry. 278: 21012-21017. PMID 12646555 DOI: 10.1074/jbc.M212773200  0.6
2003 Peisajovich SG, Blank L, Epand RF, Epand RM, Shai Y. On the interaction between gp41 and membranes: The immunodominant loop stabilizes gp41 helical hairpin conformation Journal of Molecular Biology. 326: 1489-1501. PMID 12595260 DOI: 10.1016/S0022-2836(03)00040-8  0.6
2003 Papo N, Shai Y. Exploring peptide membrane interaction using surface plasmon resonance: Differentiation between pore formation versus membrane disruption by lytic peptides Biochemistry. 42: 458-466. PMID 12525173 DOI: 10.1021/bi0267846  0.6
2003 Shai Y. Biochimica et biophysica acta - Biomembranes: Preface Biochimica Et Biophysica Acta - Biomembranes. 1614: 1-2. DOI: 10.1016/S0005-2736(03)00157-3  0.6
2002 Shai Y. Mode of action of membrane active antimicrobial peptides Biopolymers - Peptide Science Section. 66: 236-248. PMID 12491537 DOI: 10.1002/bip.10260  0.6
2002 Sal-Man N, Oren Z, Shai Y. Preassembly of membrane-active peptides is an important factor in their selectivity toward target cells Biochemistry. 41: 11921-11930. PMID 12269837 DOI: 10.1021/bi0260482  0.6
2002 Gerber D, Shai Y. Chirality-independent protein-protein recognition between transmembrane domains in vivo Journal of Molecular Biology. 322: 491-495. PMID 12225743 DOI: 10.1016/S0022-2836(02)00807-0  0.6
2002 Peisajovich SG, Epand RF, Epand RM, Shai Y. Sendai virus N-terminal fusion peptide consists of two similar repeats, both of which contribute to membrane fusion European Journal of Biochemistry. 269: 4342-4350. PMID 12199713 DOI: 10.1046/j.1432-1033.2002.03132.x  0.6
2002 Oren Z, Ramesh J, Avrahami D, Suryaprakash N, Shai Y, Jelinek R. Structures and mode of membrane interaction of a short α helical lytic peptide and its diastereomer determined by NMR, FTIR, and fluorescence spectroscopy European Journal of Biochemistry. 269: 3869-3880. PMID 12180963 DOI: 10.1046/j.1432-1033.2002.03080.x  0.6
2001 Kliger Y, Gallo SA, Peisajovich SG, Munoz-Barroso I, Avkin S, Blumenthal R, Shai Y. Mode of action of an antiviral peptide from HIV-1. Inhibition at a post-lipid mixing stage. The Journal of Biological Chemistry. 276: 1391-7. PMID 11027678 DOI: 10.1074/jbc.M004113200  1
2000 Kliger Y, Peisajovich SG, Blumenthal R, Shai Y. Membrane-induced conformational change during the activation of HIV-1 gp41. Journal of Molecular Biology. 301: 905-14. PMID 10966795 DOI: 10.1006/jmbi.2000.4004  1
2000 Kliger Y, Shai Y. Inhibition of HIV-1 entry before gp41 folds into its fusion-active conformation. Journal of Molecular Biology. 295: 163-8. PMID 10623516 DOI: 10.1006/jmbi.1999.3368  1
1999 Ben-Efraim I, Kliger Y, Hermesh C, Shai Y. Membrane-induced step in the activation of Sendai virus fusion protein. Journal of Molecular Biology. 285: 609-25. PMID 9878433 DOI: 10.1006/jmbi.1998.2370  1
1998 Gazit E, La Rocca P, Sansom MS, Shai Y. The structure and organization within the membrane of the helices composing the pore-forming domain of Bacillus thuringiensis delta-endotoxin are consistent with an "umbrella-like" structure of the pore. Proceedings of the National Academy of Sciences of the United States of America. 95: 12289-94. PMID 9770479  1
1997 Gazit E, Burshtein N, Ellar DJ, Sawyer T, Shai Y. Bacillus thuringiensis cytolytic toxin associates specifically with its synthetic helices A and C in the membrane bound state. Implications for the assembly of oligomeric transmembrane pores. Biochemistry. 36: 15546-54. PMID 9398283 DOI: 10.1021/bi9707584  1
1997 Kliger Y, Aharoni A, Rapaport D, Jones P, Blumenthal R, Shai Y. Fusion peptides derived from the HIV type 1 glycoprotein 41 associate within phospholipid membranes and inhibit cell-cell Fusion. Structure-function study. The Journal of Biological Chemistry. 272: 13496-505. PMID 9153194  1
1997 Kliger Y, Shai Y. A leucine zipper-like sequence from the cytoplasmic tail of the HIV-1 envelope glycoprotein binds and perturbs lipid bilayers. Biochemistry. 36: 5157-69. PMID 9136877 DOI: 10.1021/bi962935r  1
1996 Gazit E, Miller IR, Biggin PC, Sansom MS, Shai Y. Structure and orientation of the mammalian antibacterial peptide cecropin P1 within phospholipid membranes. Journal of Molecular Biology. 258: 860-70. PMID 8637016 DOI: 10.1006/jmbi.1996.0293  0.6
1995 Gazit E, Shai Y. The assembly and organization of the alpha 5 and alpha 7 helices from the pore-forming domain of Bacillus thuringiensis delta-endotoxin. Relevance to a functional model. The Journal of Biological Chemistry. 270: 2571-8. PMID 7852320  1
1995 Gazit E, Boman A, Boman HG, Shai Y. Interaction of the mammalian antibacterial peptide cecropin P1 with phospholipid vesicles. Biochemistry. 34: 11479-88. PMID 7547876  1
1994 Gazit E, Lee WJ, Brey PT, Shai Y. Mode of action of the antibacterial cecropin B2: a spectrofluorometric study. Biochemistry. 33: 10681-92. PMID 8075068  1
1994 Gazit E, Bach D, Kerr ID, Sansom MS, Chejanovsky N, Shai Y. The alpha-5 segment of Bacillus thuringiensis delta-endotoxin: in vitro activity, ion channel formation and molecular modelling. The Biochemical Journal. 304: 895-902. PMID 7529493  1
1993 Gazit E, Shai Y. Structural and functional characterization of the alpha 5 segment of Bacillus thuringiensis delta-endotoxin. Biochemistry. 32: 3429-36. PMID 8384882  1
1993 Gazit E, Shai Y. Structural characterization, membrane interaction, and specific assembly within phospholipid membranes of hydrophobic segments from Bacillus thuringiensis var. israelensis cytolytic toxin. Biochemistry. 32: 12363-71. PMID 8241124  1
1992 Rapaport D, Danin M, Gazit E, Shai Y. Membrane interactions of the sodium channel S4 segment and its fluorescently-labeled analogues. Biochemistry. 31: 8868-75. PMID 1327106  1
1989 Shai Y, Brunck TK, Chaiken IM. Antisense peptide recognition of sense peptides: sequence simplification and evaluation of forces underlying the interaction. Biochemistry. 28: 8804-11. PMID 2605221  0.6
1987 Shai Y, Flashner M, Chaiken IM. Anti-sense peptide recognition of sense peptides: direct quantitative characterization with the ribonuclease S-peptide system using analytical high-performance affinity chromatography. Biochemistry. 26: 669-75. PMID 3567139  0.6
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