Tom Brown - Publications

University of Oxford, Oxford, United Kingdom 

135 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Taemaitree L, Shivalingam A, El-Sagheer AH, Brown T. "Split-and-Click" sgRNA. Methods in Molecular Biology (Clifton, N.J.). 2162: 61-78. PMID 32926378 DOI: 10.1007/978-1-0716-0687-2_5  0.44
2020 Fantoni N, McGorman B, Molphy Z, Singleton D, Walsh S, El-Sagheer AH, McKee V, Brown T, Kellett A. Development of Gene-Targeted Polypyridyl Triplex Forming Oligonucleotide Hybrids. Chembiochem : a European Journal of Chemical Biology. PMID 32755000 DOI: 10.1002/cbic.202000408  0.44
2020 Wypijewska Del Nogal A, Füchtbauer AF, Bood M, Nilsson JR, Wranne MS, Sarangamath S, Pfeiffer P, Rajan VS, El-Sagheer AH, Dahlén A, Brown T, Grøtli M, Wilhelmsson LM. Getting DNA and RNA out of the dark with 2CNqA: a bright adenine analogue and interbase FRET donor. Nucleic Acids Research. PMID 32558908 DOI: 10.1093/nar/gkaa525  0.44
2020 Oudelaar AM, Beagrie RA, Gosden M, de Ornellas S, Georgiades E, Kerry J, Hidalgo D, Carrelha J, Shivalingam A, El-Sagheer AH, Telenius JM, Brown T, Buckle VJ, Socolovsky M, Higgs DR, et al. Dynamics of the 4D genome during in vivo lineage specification and differentiation. Nature Communications. 11: 2722. PMID 32483172 DOI: 10.1038/s41467-020-16598-7  0.44
2020 Epple S, Thorpe C, Baker YR, El-Sagheer AH, Brown T. Consecutive 5'- and 3'-amide linkages stabilise antisense oligonucleotides and elicit an efficient RNase H response. Chemical Communications (Cambridge, England). PMID 32292963 DOI: 10.1039/d0cc00444h  0.44
2020 Shivalingam A, Taemaitree L, El-Sagheer AH, Brown T. Squaramides and Ureas: A Flexible Approach to Polymerase-Compatible Nucleic Acid Assembly. Angewandte Chemie (International Ed. in English). PMID 32153132 DOI: 10.1002/anie.202000209  0.44
2020 Hardwick JS, Haugland MM, El-Sagheer AH, Ptchelkine D, Beierlein FR, Lane AN, Brown T, Lovett JE, Anderson EA. 2'-Alkynyl spin-labelling is a minimally perturbing tool for DNA structural analysis. Nucleic Acids Research. PMID 32052020 DOI: 10.1093/nar/gkaa086  0.44
2020 Füchtbauer AF, Wranne MS, Sarangamath S, Bood M, El-Sagheer AH, Brown T, Gradén H, Grøtli M, Wilhelmsson LM. Lighting Up DNA with the Environment-Sensitive Bright Adenine Analogue qAN4. Chempluschem. 85: 319-326. PMID 32045137 DOI: 10.1002/cplu.201900712  0.44
2020 Sayoh I, Rusling DA, Brown T, Fox KR. DNA Structural Changes Induced by Intermolecular Triple Helix Formation. Acs Omega. 5: 1679-1687. PMID 32010842 DOI: 10.1021/acsomega.9b03776  0.32
2020 Paoletti F, El-Sagheer AH, Allard J, Brown T, Dushek O, Esashi F. Molecular flexibility of DNA as a key determinant of RAD51 recruitment. The Embo Journal. e103002. PMID 31943278 DOI: 10.15252/embj.2019103002  0.44
2019 Panattoni A, El-Sagheer AH, Brown T, Kellett A, Hocek M. Oxidative DNA Cleavage with Clip-Phenanthroline Triplex Forming Oligonucleotide Hybrids. Chembiochem : a European Journal of Chemical Biology. PMID 31680391 DOI: 10.1002/cbic.201900670  0.44
2019 Thomas AM, Brolih S, McGouran JF, El-Sagheer AH, Ptchelkine D, Jones M, McDonald NQ, McHugh PJ, Brown T. Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors. Chemical Communications (Cambridge, England). PMID 31497827 DOI: 10.1039/c9cc05476f  0.44
2019 Jackson MR, Bavelaar BM, Waghorn PA, Gill MR, El-Sagheer AH, Brown T, Tarsounas M, Vallis KA. Radiolabeled oligonucleotides targeting the RNA subunit of telomerase inhibit telomerase and induce DNA damage in telomerase-positive cancer cells. Cancer Research. PMID 31311806 DOI: 10.1158/0008-5472.CAN-18-3594  0.44
2019 Klimkowski P, De Ornellas S, Singleton D, El-Sagheer AH, Brown T. Design of thiazole orange oligonucleotide probes for detection of DNA and RNA by fluorescence and duplex melting. Organic & Biomolecular Chemistry. PMID 31157811 DOI: 10.1039/c9ob00885c  0.44
2019 Thorpe C, Epple S, Woods B, El-Sagheer AH, Brown T. Synthesis and biophysical properties of carbamate-locked nucleic acid (LNA) oligonucleotides with potential antisense applications. Organic & Biomolecular Chemistry. PMID 31099373 DOI: 10.1039/c9ob00691e  0.44
2019 Taemaitree L, Shivalingam A, El-Sagheer AH, Brown T. An artificial triazole backbone linkage provides a split-and-click strategy to bioactive chemically modified CRISPR sgRNA. Nature Communications. 10: 1610. PMID 30962447 DOI: 10.1038/s41467-019-09600-4  0.44
2019 De Fazio AF, El-Sagheer AH, Kahn JS, Nandhakumar I, Burton MR, Brown T, Muskens OL, Gang O, Kanaras AG. Light-Induced Reversible DNA Ligation of Gold Nanoparticle Superlattices. Acs Nano. PMID 30958671 DOI: 10.1021/acsnano.9b01294  0.44
2018 Dürr EM, Doherty W, Lee SY, El-Sagheer AH, Shivalingam A, McHugh PJ, Brown T, McGouran JF. Squaramide-Based 5'-Phosphate Replacements Bind to the DNA Repair Exonuclease SNM1A. Chemistryselect. 3: 12824-12829. PMID 31414040 DOI: 10.1002/slct.201803375  0.44
2018 Chen J, Baker YR, Brown A, El-Sagheer AH, Brown T. Enzyme-free synthesis of cyclic single-stranded DNA constructs containing a single triazole, amide or phosphoramidate backbone linkage and their use as templates for rolling circle amplification and nanoflower formation. Chemical Science. 9: 8110-8120. PMID 30542561 DOI: 10.1039/c8sc02952k  0.44
2018 Moros M, Kyriazi ME, El-Sagheer AH, Brown T, Tortiglione C, Kanaras AG. DNA-Coated Gold Nanoparticles for the Detection of mRNA in Live Hydra Vulgaris Animals. Acs Applied Materials & Interfaces. PMID 30525369 DOI: 10.1021/acsami.8b17846  0.44
2018 Walsh S, El-Sagheer AH, Brown T. Fluorogenic thiazole orange TOTFO probes stabilise parallel DNA triplexes at pH 7 and above. Chemical Science. 9: 7681-7687. PMID 30393529 DOI: 10.1039/c8sc02418a  0.44
2018 Baker YR, Chen J, Brown J, El-Sagheer AH, Wiseman P, Johnson E, Goddard P, Brown T. Preparation and characterization of manganese, cobalt and zinc DNA nanoflowers with tuneable morphology, DNA content and size. Nucleic Acids Research. PMID 30010979 DOI: 10.1093/nar/gky630  0.44
2018 Kumar P, Truong L, Baker YR, El-Sagheer AH, Brown T. Synthesis, Affinity for Complementary RNA and DNA, and Enzymatic Stability of Triazole-Linked Locked Nucleic Acids (t-LNAs). Acs Omega. 3: 6976-6987. PMID 29978149 DOI: 10.1021/acsomega.8b01086  0.44
2018 Amunugama R, Willcox S, Wu RA, Abdullah UB, El-Sagheer AH, Brown T, McHugh PJ, Griffith JD, Walter JC. Replication Fork Reversal during DNA Interstrand Crosslink Repair Requires CMG Unloading. Cell Reports. 23: 3419-3428. PMID 29924986 DOI: 10.1016/j.celrep.2018.05.061  0.44
2018 Giust D, Lucío MI, El-Sagheer AH, Brown T, Williams LE, Muskens OL, Kanaras AG. Graphene Oxide-Upconversion Nanoparticle Based Portable Sensors for Assessing Nutritional Deficiencies in Crops. Acs Nano. PMID 29873479 DOI: 10.1021/acsnano.8b03261  0.44
2018 Bood M, Füchtbauer AF, Wranne MS, Ro JJ, Sarangamath S, El-Sagheer AH, Rupert DLM, Fisher RS, Magennis SW, Jones AC, Höök F, Brown T, Kim BH, Dahlén A, Wilhelmsson LM, et al. Pentacyclic adenine: a versatile and exceptionally bright fluorescent DNA base analogue. Chemical Science. 9: 3494-3502. PMID 29780479 DOI: 10.1039/c7sc05448c  0.44
2018 Shishodia S, Zhang D, El-Sagheer AH, Brown T, Claridge TDW, Schofield CJ, Hopkinson RJ. NMR analyses on N-hydroxymethylated nucleobases - implications for formaldehyde toxicity and nucleic acid demethylases. Organic & Biomolecular Chemistry. PMID 29767200 DOI: 10.1039/c8ob00734a  0.44
2018 Manuguerra I, Croce S, El-Sagheer AH, Krissanaprasit A, Brown T, Gothelf KV, Manetto A. Gene assembly via one-pot chemical ligation of DNA promoted by DNA nanostructures. Chemical Communications (Cambridge, England). PMID 29662975 DOI: 10.1039/c8cc00738a  0.44
2018 Kyriazi ME, Giust D, El-Sagheer AH, Lackie PM, Muskens OL, Brown T, Kanaras AG. Multiplexed mRNA Sensing and Combinatorial-Targeted Drug Delivery Using DNA-Gold Nanoparticle Dimers. Acs Nano. PMID 29557641 DOI: 10.1021/acsnano.7b08620  0.44
2018 Midelet J, El-Sagheer AH, Brown T, Kanaras AG, Débarre A, Werts MHV. Spectroscopic and Hydrodynamic Characterisation of DNA-Linked Gold Nanoparticle Dimers in Solution using Two-Photon Photoluminescence. Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. PMID 29465817 DOI: 10.1002/cphc.201701228  0.44
2018 Piccoli J, Hein R, El-Sagheer AH, Brown T, Cilli EM, Bueno PR, Davis JJ. Redox Capacitive Assaying of CRP at a Peptide Supported Aptamer Interface. Analytical Chemistry. PMID 29411973 DOI: 10.1021/acs.analchem.7b05374  0.44
2018 Hardwick JS, Lane AN, Brown T. Epigenetic Modifications of Cytosine: Biophysical Properties, Regulation, and Function in Mammalian DNA. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. PMID 29369386 DOI: 10.1002/bies.201700199  0.4
2017 Matysiak S, Hellmuth K, El-Sagheer AH, Shivalingam A, Ariyurek Y, de Jong M, Hollestelle MJ, Out R, Brown T. Searching for avidity by chemical ligation of combinatorially self-assembled DNA-encoded ligand libraries. Organic & Biomolecular Chemistry. PMID 29215120 DOI: 10.1039/c7ob02119d  0.44
2017 Kukwikila M, Gale N, El-Sagheer AH, Brown T, Tavassoli A. Assembly of a biocompatible triazole-linked gene by one-pot click-DNA ligation. Nature Chemistry. 9: 1089-1098. PMID 29064492 DOI: 10.1038/nchem.2850  0.44
2017 El-Sagheer AH, Brown T. Single tube gene synthesis by phosphoramidate chemical ligation. Chemical Communications (Cambridge, England). PMID 28913522 DOI: 10.1039/c7cc00858a  0.44
2017 Kumar P, El-Sagheer AH, Truong L, Brown T. Locked nucleic acid (LNA) enhances binding affinity of triazole-linked DNA towards RNA. Chemical Communications (Cambridge, England). PMID 28748236 DOI: 10.1039/c7cc05159j  0.44
2017 Wang H, Zhang Y, Li R, Nie J, El-Sagheer AH, Brown T, Liu Z, Xiao W. Instrument-free quantitative gold nanoparticle-based liquid-phase colorimetric assays for use in resource-poor environments. Chemical Communications (Cambridge, England). PMID 28677697 DOI: 10.1039/c7cc03240d  0.44
2017 Wranne MS, Füchtbauer AF, Dumat B, Bood MSR, El-Sagheer AH, Brown T, Gradén H, Grøtli M, Wilhelmsson LM. Towards complete sequence flexibility of nucleic acid base analogue FRET. Journal of the American Chemical Society. PMID 28613885 DOI: 10.1021/jacs.7b04517  0.44
2017 Abdullah UB, McGouran JF, Brolih S, Ptchelkine D, El-Sagheer AH, Brown T, McHugh PJ. RPA activates the XPF-ERCC1 endonuclease to initiate processing of DNA interstrand crosslinks. The Embo Journal. PMID 28607004 DOI: 10.15252/embj.201796664  0.44
2017 Hardwick JS, Ptchelkine D, El-Sagheer AH, Tear I, Singleton D, Phillips SEV, Lane AN, Brown T. 5-Formylcytosine does not change the global structure of DNA. Nature Structural & Molecular Biology. PMID 28504696 DOI: 10.1038/nsmb.3411  0.44
2017 Shivalingam A, Tyburn AE, El-Sagheer AH, Brown T. Molecular Requirements of High-Fidelity Replication-Competent DNA Backbones for Orthogonal Chemical Ligation. Journal of the American Chemical Society. PMID 28097865 DOI: 10.1021/jacs.6b11530  0.44
2016 Plochowietz A, El-Sagheer AH, Brown T, Kapanidis AN. Stable end-sealed DNA as robust nano-rulers for single-molecule fluorescence. Chemical Science. 7: 4418-4422. PMID 30155088 DOI: 10.1039/c6sc00639f  0.44
2016 Heuer-Jungemann A, El-Sagheer AH, Lackie PM, Brown T, Kanaras AG. Selective killing of cells triggered by their mRNA signature in the presence of smart nanoparticles. Nanoscale. 8: 16857-16861. PMID 27714148 DOI: 10.1039/c6nr06154k  0.44
2016 Haugland MM, El-Sagheer AH, Porter RJ, Pena J, Brown T, Anderson EA, Lovett JE. 2'-Alkynylnucleotides: A sequence- and spin label-flexible strategy for EPR spectroscopy in DNA. Journal of the American Chemical Society. PMID 27409454 DOI: 10.1021/jacs.6b05421  0.44
2016 Qiu J, Wilson A, El-Sagheer AH, Brown T. Combination probes with intercalating anchors and proximal fluorophores for DNA and RNA detection. Nucleic Acids Research. PMID 27369379 DOI: 10.1093/nar/gkw579  0.44
2016 Abdallah HO, Ohayon YP, Chandrasekaran AR, Sha R, Fox KR, Brown T, Rusling DA, Mao C, Seeman NC. Stabilisation of self-assembled DNA crystals by triplex-directed photo-cross-linking. Chemical Communications (Cambridge, England). PMID 27265774 DOI: 10.1039/c6cc03695c  0.32
2016 Meng W, Muscat RA, McKee ML, Milnes PJ, El-Sagheer AH, Bath J, Davis BG, Brown T, O'Reilly RK, Turberfield AJ. An autonomous molecular assembler for programmable chemical synthesis. Nature Chemistry. 8: 542-548. PMID 27219697 DOI: 10.1038/nchem.2495  0.44
2016 Ren X, El-Sagheer AH, Brown T. Efficient enzymatic synthesis and dual-colour fluorescent labelling of DNA probes using long chain azido-dUTP and BCN dyes. Nucleic Acids Research. PMID 26819406 DOI: 10.1093/nar/gkw028  0.44
2015 El-Sagheer AH, Brown T. A triazole linkage that mimics the DNA phosphodiester group in living systems. Quarterly Reviews of Biophysics. 48: 429-36. PMID 26537402 DOI: 10.1017/S0033583515000141  0.44
2015 Kimber ST, Brown T, Fox KR. The effect of sequence context on the activity of cytosine DNA glycosylases. Molecular Biosystems. PMID 26463365 DOI: 10.1039/c5mb00532a  0.44
2015 Harimech PK, Gerrard SR, El-Sagheer AH, Brown T, Kanaras AG. Reversible Ligation of Programmed DNA-Gold Nanoparticle Assemblies. Journal of the American Chemical Society. 137: 9242-5. PMID 26192342 DOI: 10.1021/jacs.5b05683  0.44
2015 Papadopoulou E, Meneghello M, Marafini P, Johnson RP, Brown T, Bartlett PN. The effect of temperature on electrochemically driven denaturation monitored by SERS. Bioelectrochemistry (Amsterdam, Netherlands). PMID 26145815 DOI: 10.1016/j.bioelechem.2015.06.007  0.44
2015 French DJ, Richardson JA, Howard RL, Brown T, Debenham PG. Synthesis and use of universal sequence probes in fluorogenic multi-strand hybridisation complexes for economical nucleic acid testing. Molecular and Cellular Probes. PMID 25981184 DOI: 10.1016/j.mcp.2015.05.007  0.44
2015 Ren X, El-Sagheer AH, Brown T. Azide and trans-cyclooctene dUTPs: incorporation into DNA probes and fluorescent click-labelling. The Analyst. 140: 2671-8. PMID 25734317 DOI: 10.1039/c5an00158g  0.44
2015 Alonso-Cristobal P, Vilela P, El-Sagheer A, Lopez-Cabarcos E, Brown T, Muskens OL, Rubio-Retama J, Kanaras AG. Highly Sensitive DNA Sensor Based on Upconversion Nanoparticles and Graphene Oxide. Acs Applied Materials & Interfaces. 7: 12422-9. PMID 25622622 DOI: 10.1021/am507591u  0.44
2015 Papadopoulou E, Goodchild SA, Cleary DW, Weller SA, Gale N, Stubberfield MR, Brown T, Bartlett PN. Using surface-enhanced Raman spectroscopy and electrochemically driven melting to discriminate Yersinia pestis from Y. pseudotuberculosis based on single nucleotide polymorphisms within unpurified polymerase chain reaction amplicons. Analytical Chemistry. 87: 1605-12. PMID 25551670 DOI: 10.1021/ac503063c  0.44
2015 Howard RL, French DJ, Richardson JA, O'Neill CE, Andreou MP, Brown T, Clark D, Clarke IN, Holloway JW, Marsh P, Debenham PG. Rapid detection of diagnostic targets using isothermal amplification and HyBeacon probes--a homogenous system for sequence-specific detection. Molecular and Cellular Probes. 29: 92-8. PMID 25542839 DOI: 10.1016/j.mcp.2014.12.001  0.44
2015 Heuer-Jungemann A, Kiessling L, Stratakis E, Kymakis E, El-Sagheer AH, Brown T, Kanaras AG. Programming the assembly of gold nanoparticles on graphene oxide sheets using DNA Journal of Materials Chemistry C. 3: 9379-9384. DOI: 10.1039/c5tc01999k  0.44
2015 Harimech PK, Gerrard SR, El-Sagheer AH, Brown T, Kanaras AG. Reversible Ligation of Programmed DNA-Gold Nanoparticle Assemblies Journal of the American Chemical Society. 137: 9242-9245. DOI: 10.1021/jacs.5b05683  0.44
2014 Ren X, Gerowska M, El-Sagheer AH, Brown T. Enzymatic incorporation and fluorescent labelling of cyclooctyne-modified deoxyuridine triphosphates in DNA. Bioorganic & Medicinal Chemistry. 22: 4384-90. PMID 24953951 DOI: 10.1016/j.bmc.2014.05.050  0.44
2014 Chen X, El-Sagheer AH, Brown T. Reverse transcription through a bulky triazole linkage in RNA: implications for RNA sequencing. Chemical Communications (Cambridge, England). 50: 7597-600. PMID 24889467 DOI: 10.1039/c4cc03027c  0.44
2014 Bosaeus N, El-Sagheer AH, Brown T, Ã…kerman B, Nordén B. Force-induced melting of DNA--evidence for peeling and internal melting from force spectra on short synthetic duplex sequences. Nucleic Acids Research. 42: 8083-91. PMID 24838568 DOI: 10.1093/nar/gku441  0.44
2014 Kimber ST, Brown T, Fox KR. A mutant of uracil DNA glycosylase that distinguishes between cytosine and 5-methylcytosine. Plos One. 9: e95394. PMID 24740413 DOI: 10.1371/journal.pone.0095394  0.44
2014 Rusling DA, Chandrasekaran AR, Ohayon YP, Brown T, Fox KR, Sha R, Mao C, Seeman NC. Functionalizing designer DNA crystals with a triple-helical veneer. Angewandte Chemie (International Ed. in English). 53: 3979-82. PMID 24615910 DOI: 10.1002/anie.201309914  0.44
2014 Birts CN, Sanzone AP, El-Sagheer AH, Blaydes JP, Brown T, Tavassoli A. Transcription of click-linked DNA in human cells. Angewandte Chemie (International Ed. in English). 53: 2362-5. PMID 24452865 DOI: 10.1002/anie.201308691  0.44
2014 Riley JA, Brown T, Gale N, Herniman J, Langley GJ. Self-reporting hybridisation assay for miRNA analysis. The Analyst. 139: 1088-92. PMID 24404560 DOI: 10.1039/c3an01825c  0.44
2014 Lercher L, McDonough MA, El-Sagheer AH, Thalhammer A, Kriaucionis S, Brown T, Schofield CJ. Structural insights into how 5-hydroxymethylation influences transcription factor binding. Chemical Communications (Cambridge, England). 50: 1794-6. PMID 24287551 DOI: 10.1039/c3cc48151d  0.44
2014 Lou C, Dallmann A, Marafini P, Gao R, Brown T. Enhanced H-bonding and π-stacking in DNA: A potent duplex-stabilizing and mismatch sensing nucleobase analogue Chemical Science. 5: 3836-3844. DOI: 10.1039/c4sc00948g  0.44
2013 Heuer-Jungemann A, Harimech PK, Brown T, Kanaras AG. Gold nanoparticles and fluorescently-labelled DNA as a platform for biological sensing. Nanoscale. 5: 9503-10. PMID 23982570 DOI: 10.1039/c3nr03707j  0.44
2013 Heuer-Jungemann A, Kirkwood R, El-Sagheer AH, Brown T, Kanaras AG. Copper-free click chemistry as an emerging tool for the programmed ligation of DNA-functionalised gold nanoparticles. Nanoscale. 5: 7209-12. PMID 23828172 DOI: 10.1039/c3nr02362a  0.44
2013 Qiu J, El-Sagheer AH, Brown T. Solid phase click ligation for the synthesis of very long oligonucleotides. Chemical Communications (Cambridge, England). 49: 6959-61. PMID 23814786 DOI: 10.1039/c3cc42451k  0.44
2013 Fonvielle M, Li de La Sierra-Gallay I, El-Sagheer AH, Lecerf M, Patin D, Mellal D, Mayer C, Blanot D, Gale N, Brown T, van Tilbeurgh H, Ethève-Quelquejeu M, Arthur M. The structure of FemX(Wv) in complex with a peptidyl-RNA conjugate: mechanism of aminoacyl transfer from Ala-tRNA(Ala) to peptidoglycan precursors. Angewandte Chemie (International Ed. in English). 52: 7278-81. PMID 23744707 DOI: 10.1002/anie.201301411  0.44
2013 Milton JA, Patole S, Yin H, Xiao Q, Brown T, Melvin T. Efficient self-assembly of DNA-functionalized fluorophores and gold nanoparticles with DNA functionalized silicon surfaces: the effect of oligomer spacers. Nucleic Acids Research. 41: e80. PMID 23361467 DOI: 10.1093/nar/gkt031  0.44
2013 Crawford R, Erben CM, Periz J, Hall LM, Brown T, Turberfield AJ, Kapanidis AN. Non-covalent single transcription factor encapsulation inside a DNA cage. Angewandte Chemie (International Ed. in English). 52: 2284-8. PMID 23325751 DOI: 10.1002/anie.201207914  0.44
2013 Hannestad JK, Brune R, Czolkos I, Jesorka A, El-Sagheer AH, Brown T, Albinsson B, Orwar O. Kinetics of diffusion-mediated DNA hybridization in lipid monolayer films determined by single-molecule fluorescence spectroscopy. Acs Nano. 7: 308-15. PMID 23215045 DOI: 10.1021/nn304010p  0.44
2013 Johnson RP, Gale N, Richardson JA, Brown T, Bartlett PN. Denaturation of dsDNA immobilised at a negatively charged gold electrode is not caused by electrostatic repulsion Chemical Science. 4: 1625-1632. DOI: 10.1039/c3sc22147d  0.44
2012 Riley JA, Brown T, Gale N, Herniman J, Langley GJ. Self reporting RNA probes as an alternative to cleavable small molecule mass tags. The Analyst. 137: 5817-22. PMID 23096125 DOI: 10.1039/c2an36086a  0.44
2012 Bosaeus N, El-Sagheer AH, Brown T, Smith SB, Akerman B, Bustamante C, Nordén B. Tension induces a base-paired overstretched DNA conformation. Proceedings of the National Academy of Sciences of the United States of America. 109: 15179-84. PMID 22949705 DOI: 10.1073/pnas.1213172109  0.44
2012 Rusling DA, Nandhakumar IS, Brown T, Fox KR. Triplex-directed covalent cross-linking of a DNA nanostructure. Chemical Communications (Cambridge, England). 48: 9592-4. PMID 22911369 DOI: 10.1039/c2cc35407a  0.44
2012 Sanzone AP, El-Sagheer AH, Brown T, Tavassoli A. Assessing the biocompatibility of click-linked DNA in Escherichia coli. Nucleic Acids Research. 40: 10567-75. PMID 22904087 DOI: 10.1093/nar/gks756  0.44
2012 Shelbourne M, Brown T, El-Sagheer AH, Brown T. Fast and efficient DNA crosslinking and multiple orthogonal labelling by copper-free click chemistry. Chemical Communications (Cambridge, England). 48: 11184-6. PMID 22892959 DOI: 10.1039/c2cc35084j  0.44
2012 Johnson RP, Richardson JA, Brown T, Bartlett PN. A label-free, electrochemical SERS-based assay for detection of DNA hybridization and discrimination of mutations. Journal of the American Chemical Society. 134: 14099-107. PMID 22835041 DOI: 10.1021/ja304663t  0.44
2012 Hall LM, Gerowska M, Brown T. A highly fluorescent DNA toolkit: synthesis and properties of oligonucleotides containing new Cy3, Cy5 and Cy3B monomers. Nucleic Acids Research. 40: e108. PMID 22495935 DOI: 10.1093/nar/gks303  0.44
2012 Rusling DA, Nandhakumar IS, Brown T, Fox KR. Triplex-directed recognition of a DNA nanostructure assembled by crossover strand exchange. Acs Nano. 6: 3604-13. PMID 22443318 DOI: 10.1021/nn300718z  0.44
2012 El-Sagheer AH, Brown T. Click nucleic acid ligation: applications in biology and nanotechnology. Accounts of Chemical Research. 45: 1258-67. PMID 22439702 DOI: 10.1021/ar200321n  0.44
2012 Johnson RP, Richardson JA, Brown T, Bartlett PN. Real-time surface-enhanced Raman spectroscopy monitoring of surface pH during electrochemical melting of double-stranded DNA. Langmuir : the Acs Journal of Surfaces and Colloids. 28: 5464-70. PMID 22369584 DOI: 10.1021/la204794g  0.44
2012 Johnson RP, Gao R, Brown T, Bartlett PN. The effect of base-pair sequence on electrochemically driven denaturation. Bioelectrochemistry (Amsterdam, Netherlands). 85: 7-13. PMID 22192638 DOI: 10.1016/j.bioelechem.2011.11.003  0.44
2012 Cardew AS, Brown T, Fox KR. Secondary binding sites for heavily modified triplex forming oligonucleotides. Nucleic Acids Research. 40: 3753-62. PMID 22180535 DOI: 10.1093/nar/gkr1119  0.44
2011 Dallmann A, El-Sagheer AH, Dehmel L, Mügge C, Griesinger C, Ernsting NP, Brown T. Structure and dynamics of triazole-linked DNA: Biocompatibility explained Chemistry - a European Journal. 17: 14714-14717. PMID 22131102 DOI: 10.1002/chem.201102979  0.44
2011 Lou C, Shelbourne M, Fox KR, Brown T. 2'-Aminoethoxy-2-amino-3-methylpyridine in triplex-forming oligonucleotides: high affinity, selectivity and resistance to enzymatic degradation. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 14851-6. PMID 22127905 DOI: 10.1002/chem.201102287  0.44
2011 el-Sagheer AH, Brown T. Efficient RNA synthesis by in vitro transcription of a triazole-modified DNA template. Chemical Communications (Cambridge, England). 47: 12057-8. PMID 21961113 DOI: 10.1039/c1cc14316f  0.44
2011 El-Sagheer AH, Sanzone AP, Gao R, Tavassoli A, Brown T. Biocompatible artificial DNA linker that is read through by DNA polymerases and is functional in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 108: 11338-43. PMID 21709264 DOI: 10.1073/pnas.1101519108  0.44
2011 Shelbourne M, Chen X, Brown T, El-Sagheer AH. Fast copper-free click DNA ligation by the ring-strain promoted alkyne-azide cycloaddition reaction. Chemical Communications (Cambridge, England). 47: 6257-9. PMID 21547301 DOI: 10.1039/c1cc10743g  0.44
2011 Walsh JM, Bouamaied I, Brown T, Wilhelmsson LM, Beuning PJ. Discrimination against the cytosine analog tC by Escherichia coli DNA polymerase IV DinB. Journal of Molecular Biology. 409: 89-100. PMID 21477595 DOI: 10.1016/j.jmb.2011.03.069  0.44
2011 Thalhammer A, Hansen AS, El-Sagheer AH, Brown T, Schofield CJ. Hydroxylation of methylated CpG dinucleotides reverses stabilisation of DNA duplexes by cytosine 5-methylation. Chemical Communications (Cambridge, England). 47: 5325-7. PMID 21451870 DOI: 10.1039/c0cc05671e  0.44
2011 Fox KR, Brown T. Formation of stable DNA triplexes. Biochemical Society Transactions. 39: 629-34. PMID 21428952 DOI: 10.1042/BST0390629  0.44
2011 Dierckx A, Dinér P, El-Sagheer AH, Kumar JD, Brown T, Grøtli M, Wilhelmsson LM. Characterization of photophysical and base-mimicking properties of a novel fluorescent adenine analogue in DNA. Nucleic Acids Research. 39: 4513-24. PMID 21278417 DOI: 10.1093/nar/gkr010  0.44
2011 Hansen AS, Thalhammer A, El-Sagheer AH, Brown T, Schofield CJ. Improved synthesis of 5-hydroxymethyl-2'-deoxycytidine phosphoramidite using a 2'-deoxyuridine to 2'-deoxycytidine conversion without temporary protecting groups. Bioorganic & Medicinal Chemistry Letters. 21: 1181-4. PMID 21256007 DOI: 10.1016/j.bmcl.2010.12.098  0.44
2011 El-Sagheer AH, Cheong VV, Brown T. Rapid chemical ligation of oligonucleotides by the Diels-Alder reaction. Organic & Biomolecular Chemistry. 9: 232-5. PMID 21072410 DOI: 10.1039/c0ob00451k  0.44
2010 Gerrard SR, Edrees MM, Bouamaied I, Fox KR, Brown T. CG base pair recognition within DNA triple helices by modified N-methylpyrrolo-dC nucleosides. Organic & Biomolecular Chemistry. 8: 5087-96. PMID 20835452 DOI: 10.1039/c0ob00119h  0.44
2010 Börjesson K, Wiberg J, El-Sagheer AH, Ljungdahl T, Mårtensson J, Brown T, Nordén B, Albinsson B. Functionalized nanostructures: redox-active porphyrin anchors for supramolecular DNA assemblies. Acs Nano. 4: 5037-46. PMID 20809571 DOI: 10.1021/nn100667b  0.44
2010 El-Sagheer AH, Brown T. New strategy for the synthesis of chemically modified RNA constructs exemplified by hairpin and hammerhead ribozymes. Proceedings of the National Academy of Sciences of the United States of America. 107: 15329-34. PMID 20713730 DOI: 10.1073/pnas.1006447107  0.44
2010 Lou C, Xiao Q, Brennan L, Light ME, Vergara-Irigaray N, Atkinson EM, Holden-Dye LM, Fox KR, Brown T. Synthesis and properties of triplex-forming oligonucleotides containing 2'-O-(2-methoxyethyl)-5-(3-aminoprop-1-ynyl)-uridine. Bioorganic & Medicinal Chemistry. 18: 6389-97. PMID 20674370 DOI: 10.1016/j.bmc.2010.07.005  0.44
2010 Corrigan DK, Gale N, Brown T, Bartlett PN. Analysis of short tandem repeats by using SERS monitoring and electrochemical melting Angewandte Chemie - International Edition. 49: 5917-5920. PMID 20623816 DOI: 10.1002/anie.201001389  0.44
2010 Brown T, Charlier P, Herman R, Schofield CJ, Sauvage E. Structural basis for the interaction of lactivicins with serine beta-lactamases. Journal of Medicinal Chemistry. 53: 5890-4. PMID 20593835 DOI: 10.1021/jm100437u  0.44
2010 Gambinossi F, Banchelli M, Durand A, Berti D, Brown T, Caminati G, Baglioni P. Modulation of density and orientation of amphiphilic DNA anchored to phospholipid membranes. I. Supported lipid bilayers. The Journal of Physical Chemistry. B. 114: 7338-47. PMID 20446700 DOI: 10.1021/jp100730x  0.44
2010 Banchelli M, Gambinossi F, Durand A, Caminati G, Brown T, Berti D, Baglioni P. Modulation of density and orientation of amphiphilic DNA on phospholipid membranes. II. Vesicles. The Journal of Physical Chemistry. B. 114: 7348-58. PMID 20446699 DOI: 10.1021/jp100731c  0.44
2010 Ben Gaied N, Richardson JA, Singleton DG, Zhao Z, French D, Brown T. End-capped HyBeacon probes for the analysis of human genetic polymorphisms related to warfarin metabolism. Organic & Biomolecular Chemistry. 8: 2728-34. PMID 20393654 DOI: 10.1039/c001177k  0.44
2010 Lundberg EP, El-Sagheer AH, Kocalka P, Wilhelmsson LM, Brown T, Nordén B. A new fixation strategy for addressable nano-network building blocks. Chemical Communications (Cambridge, England). 46: 3714-6. PMID 20386862 DOI: 10.1039/c001513j  0.44
2010 El-Sagheer AH, Brown T. Click chemistry with DNA. Chemical Society Reviews. 39: 1388-405. PMID 20309492 DOI: 10.1039/b901971p  0.44
2010 Iqbal A, Arunlanantham H, Brown T, Chowdhury R, Clifton IJ, Kershaw NJ, Hewitson KS, McDonough MA, Schofield CJ. Crystallographic and mass spectrometric analyses of a tandem GNAT protein from the clavulanic acid biosynthesis pathway. Proteins. 78: 1398-407. PMID 20014241 DOI: 10.1002/prot.22653  0.44
2009 Chernatynskaya AV, Deleeuw L, Trent JO, Brown T, Lane AN. Structural analysis of the DNA target site and its interaction with Mbp1. Organic & Biomolecular Chemistry. 7: 4981-91. PMID 19907790 DOI: 10.1039/b912309a  0.4
2009 Ben Gaied N, Zhao Z, Gerrard SR, Fox KR, Brown T. Potent triple helix stabilization by 5',3'-modified triplex-forming oligonucleotides. Chembiochem : a European Journal of Chemical Biology. 10: 1839-51. PMID 19554592 DOI: 10.1002/cbic.200900232  0.44
2009 Börjesson K, Preus S, El-Sagheer AH, Brown T, Albinsson B, Wilhelmsson LM. Nucleic acid base analog FRET-pair facilitating detailed structural measurements in nucleic acid containing systems. Journal of the American Chemical Society. 131: 4288-93. PMID 19317504 DOI: 10.1021/ja806944w  0.44
2009 El-Sagheer AH, Brown T. Synthesis and polymerase chain reaction amplification of DNA strands containing an unnatural triazole linkage. Journal of the American Chemical Society. 131: 3958-64. PMID 19292490 DOI: 10.1021/ja8065896  0.44
2009 Rusling DA, Peng G, Srinivasan N, Fox KR, Brown T. DNA triplex formation with 5-dimethylaminopropargyl deoxyuridine. Nucleic Acids Research. 37: 1288-96. PMID 19139069 DOI: 10.1093/nar/gkn1060  0.44
2009 Baldelli Bombelli F, Betti F, Gambinossi F, Caminati G, Brown T, Baglioni P, Berti D. Closed nanoconstructs assembled by step-by-step ss-DNA coupling assisted by phospholipid membranes Soft Matter. 5: 1639-1645. DOI: 10.1039/b816716h  0.44
2009 Mahajan S, Richardson J, Gaied NB, Zhao Z, Brown T, Bartlett PN. The use of an electroactive marker as a SERS label in an E-melting mutation discrimination assay Electroanalysis. 21: 2190-2197. DOI: 10.1002/elan.200904681  0.44
2008 Gale N, French DJ, Howard RL, McDowell DG, Debenham PG, Brown T. Rapid typing of STRs in the human genome by HyBeacon melting. Organic & Biomolecular Chemistry. 6: 4553-9. PMID 19039363 DOI: 10.1039/b813431f  0.44
2008 Mahajan S, Richardson J, Brown T, Bartlett PN. SERS-melting: A new method for discriminating mutations in DNA sequences Journal of the American Chemical Society. 130: 15589-15601. PMID 19006412 DOI: 10.1021/ja805517q  0.44
2008 Bombelli FB, Gambinossi F, Lagi M, Berti D, Caminati G, Brown T, Sciortino F, Norden B, Baglioni P. DNA closed nanostructures: a structural and Monte Carlo simulation study. The Journal of Physical Chemistry. B. 112: 15283-94. PMID 18989907 DOI: 10.1021/jp804544u  0.44
2008 French DJ, McDowell DG, Debenham P, Gale N, Brown T. HyBeacon probes for rapid DNA sequence detection and allele discrimination Methods in Molecular Biology (Clifton, N.J.). 429: 171-185. PMID 18695966 DOI: 10.1007/978-1-60327-040-3_12  0.44
2008 Banchelli M, Betti F, Berti D, Caminati G, Bombelli FB, Brown T, Wilhelmsson LM, Nordén B, Baglioni P. Phospholipid membranes decorated by cholesterol-based oligonucleotides as soft hybrid nanostructures. The Journal of Physical Chemistry. B. 112: 10942-52. PMID 18693696 DOI: 10.1021/jp802415t  0.44
2008 Stevenson R, Baxter HC, Aitken A, Brown T, Baxter RL. Binding of 14-3-3 proteins to a single stranded oligodeoxynucleotide aptamer Bioorganic Chemistry. 36: 215-219. PMID 18279908 DOI: 10.1016/j.bioorg.2007.12.005  0.44
2007 Rachwal PA, Findlow IS, Werner JM, Brown T, Fox KR. Intramolecular DNA quadruplexes with different arrangements of short and long loops. Nucleic Acids Research. 35: 4214-22. PMID 17576685 DOI: 10.1093/nar/gkm316  0.44
2007 Tumpane J, Sandin P, Kumar R, Powers VEC, Lundberg EP, Gale N, Baglioni P, Lehn JM, Albinsson B, Lincoln P, Wilhelmsson LM, Brown T, Nordén B. Addressable high-information-density DNA nanostructures Chemical Physics Letters. 440: 125-129. DOI: 10.1016/j.cplett.2007.04.018  0.44
2005 May JP, Brown LJ, van Delft I, Thelwell N, Harley K, Brown T. Synthesis and evaluation of a new non-fluorescent quencher in fluorogenic oligonucleotide probes for real-time PCR. Organic & Biomolecular Chemistry. 3: 2534-42. PMID 15999185 DOI: 10.1039/b504759e  0.44
2003 Dobson N, McDowell DG, French DJ, Brown LJ, Mellor JM, Brown T. Synthesis of HyBeacons and dual-labelled probes containing 2′-fluorescent groups for use in genetic analysis Chemical Communications. 1234-1235. PMID 12809207 DOI: 10.1039/B302855K  0.44
2003 May JP, Brown LJ, Rudloff I, Brown T. A new dark quencher for use in genetic analysis. Chemical Communications (Cambridge, England). 970-1. PMID 12744324 DOI: 10.1039/B300934C  0.44
2003 Gyi JI, Gao D, Conn GL, Trent JO, Brown T, Lane AN. The solution structure of a DNA*RNA duplex containing 5-propynyl U and C; comparison with 5-Me modifications. Nucleic Acids Research. 31: 2683-93. PMID 12736318  0.4
2002 Pinheiro P, Scarlett G, Rodger A, Rodger PM, Murray A, Brown T, Newbury SF, McClellan JA. Structures of CUG repeats in RNA. Potential implications for human genetic diseases. The Journal of Biological Chemistry. 277: 35183-90. PMID 12077125 DOI: 10.1074/jbc.M202235200  0.44
2002 Sollogoub M, Darby RA, Cuenoud B, Brown T, Fox KR. Stable DNA triple helix formation using oligonucleotides containing 2'-aminoethoxy,5-propargylamino-U. Biochemistry. 41: 7224-31. PMID 12044153 DOI: 10.1021/bi020164n  0.44
2002 Darby RA, Sollogoub M, McKeen C, Brown L, Risitano A, Brown N, Barton C, Brown T, Fox KR. High throughput measurement of duplex, triplex and quadruplex melting curves using molecular beacons and a LightCycler. Nucleic Acids Research. 30: e39. PMID 11972354  0.44
2002 Sollogoub M, Fox KR, Powers VEC, Brown T. First synthesis of 1-deazacytidine, the C-nucleoside analogue of cytidine Tetrahedron Letters. 43: 3121-3123. DOI: 10.1016/S0040-4039(02)00481-1  0.44
2001 Brown LJ, May JP, Brown T. Synthesis of a modified thymidine monomer for site-specific incorporation of reporter groups into oligonucleotides Tetrahedron Letters. 42: 2587-2591. DOI: 10.1016/S0040-4039(01)00224-6  0.44
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