Cyrus H. Chothia - Publications

Affiliations: 
MRC Laboratory of Molecular Biology University of Cambridge, Cambridge, England, United Kingdom 
Area:
Computational Molecular Biology
Website:
https://www2.mrc-lmb.cam.ac.uk/group-leaders/emeritus/cyrus-chothia/

157 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Andreeva A, Howorth D, Chothia C, Kulesha E, Murzin AG. Investigating Protein Structure and Evolution with SCOP2. Current Protocols in Bioinformatics / Editoral Board, Andreas D. Baxevanis ... [Et Al.]. 49: 1.26.1-1.26.21. PMID 25754991 DOI: 10.1002/0471250953.Bi0126S49  0.8
2015 Lewis TE, Sillitoe I, Andreeva A, Blundell TL, Buchan DW, Chothia C, Cozzetto D, Dana JM, Filippis I, Gough J, Jones DT, Kelley LA, Kleywegt GJ, Minneci F, Mistry J, et al. Genome3D: exploiting structure to help users understand their sequences. Nucleic Acids Research. 43: D382-6. PMID 25348407 DOI: 10.1093/Nar/Gku973  0.8
2014 Andreeva A, Howorth D, Chothia C, Kulesha E, Murzin AG. SCOP2 prototype: a new approach to protein structure mining. Nucleic Acids Research. 42: D310-4. PMID 24293656 DOI: 10.1093/Nar/Gkt1242  0.8
2013 Lewis TE, Sillitoe I, Andreeva A, Blundell TL, Buchan DW, Chothia C, Cuff A, Dana JM, Filippis I, Gough J, Hunter S, Jones DT, Kelley LA, Kleywegt GJ, Minneci F, et al. Genome3D: a UK collaborative project to annotate genomic sequences with predicted 3D structures based on SCOP and CATH domains. Nucleic Acids Research. 41: D499-507. PMID 23203986 DOI: 10.1093/Nar/Gks1266  0.8
2012 Perica T, Chothia C, Teichmann SA. Evolution of oligomeric state through geometric coupling of protein interfaces. Proceedings of the National Academy of Sciences of the United States of America. 109: 8127-32. PMID 22566652 DOI: 10.1073/Pnas.1120028109  0.8
2011 de Lima Morais DA, Fang H, Rackham OJ, Wilson D, Pethica R, Chothia C, Gough J. SUPERFAMILY 1.75 including a domain-centric gene ontology method. Nucleic Acids Research. 39: D427-34. PMID 21062816 DOI: 10.1093/Nar/Gkq1130  0.8
2010 Perica T, Chothia C. Ubiquitin-molecular mechanisms for recognition of different structures Current Opinion in Structural Biology. 20: 367-376. PMID 20456943 DOI: 10.1016/J.Sbi.2010.03.007  0.8
2009 Chothia C, Gough J. Genomic and structural aspects of protein evolution. The Biochemical Journal. 419: 15-28. PMID 19272021 DOI: 10.1042/Bj20090122  0.8
2009 Wilson D, Pethica R, Zhou Y, Talbot C, Vogel C, Madera M, Chothia C, Gough J. SUPERFAMILY--sophisticated comparative genomics, data mining, visualization and phylogeny. Nucleic Acids Research. 37: D380-6. PMID 19036790 DOI: 10.1093/Nar/Gkn762  0.8
2008 Andreeva A, Howorth D, Chandonia JM, Brenner SE, Hubbard TJ, Chothia C, Murzin AG. Data growth and its impact on the SCOP database: new developments. Nucleic Acids Research. 36: D419-25. PMID 18000004 DOI: 10.1093/Nar/Gkm993  0.8
2007 Sasidharan R, Chothia C. The selection of acceptable protein mutations Proceedings of the National Academy of Sciences of the United States of America. 104: 10080-10085. PMID 17540730 DOI: 10.1073/Pnas.0703737104  0.8
2007 Bashton M, Chothia C. The generation of new protein functions by the combination of domains. Structure (London, England : 1993). 15: 85-99. PMID 17223535 DOI: 10.1016/J.Str.2006.11.009  0.8
2007 Wilson D, Madera M, Vogel C, Chothia C, Gough J. The SUPERFAMILY database in 2007: Families and functions Nucleic Acids Research. 35: D308-D313. PMID 17098927 DOI: 10.1093/Nar/Gkl910  0.8
2006 Levy ED, Pereira-Leal JB, Chothia C, Teichmann SA. 3D complex: a structural classification of protein complexes. Plos Computational Biology. 2: e155. PMID 17112313 DOI: 10.1371/Journal.Pcbi.0020155  0.8
2006 Vogel C, Chothia C. Protein family expansions and biological complexity Plos Computational Biology. 2: 370-382. PMID 16733546 DOI: 10.1371/Journal.Pcbi.0020048  0.8
2006 Han JH, Kerrison N, Chothia C, Teichmann SA. Divergence of interdomain geometry in two-domain proteins. Structure (London, England : 1993). 14: 935-45. PMID 16698554 DOI: 10.1016/J.Str.2006.01.016  0.8
2004 De Bono B, Madera M, Chothia C. V H gene segments in the mouse and human genomes Journal of Molecular Biology. 342: 131-143. PMID 15313612 DOI: 10.1016/J.Jmb.2004.06.055  0.8
2004 Gough J, Chothia C. The linked conservation of structure and function in a family of high diversity: The monomeric cupredoxins Structure. 12: 917-925. PMID 15274913 DOI: 10.1016/J.Str.2004.03.029  0.8
2004 Vogel C, Bashton M, Kerrison ND, Chothia C, Teichmann SA. Structure, function and evolution of multidomain proteins. Current Opinion in Structural Biology. 14: 208-16. PMID 15093836 DOI: 10.1016/J.Sbi.2004.03.011  0.8
2004 Madera M, Vogel C, Kummerfeld SK, Chothia C, Gough J. The SUPERFAMILY database in 2004: Additions and improvements Nucleic Acids Research. 32: D235-D239. PMID 14681402 DOI: 10.1093/Nar/Gkh117  0.8
2004 Andreeva A, Howorth D, Brenner SE, Hubbard TJ, Chothia C, Murzin AG. SCOP database in 2004: refinements integrate structure and sequence family data. Nucleic Acids Research. 32: D226-9. PMID 14681400 DOI: 10.1093/Nar/Gkh039  0.8
2003 Vogel C, Teichmann SA, Chothia C. The immunoglobulin superfamily in Drosophila melanogaster and Caenorhabditis elegans and the evolution of complexity. Development (Cambridge, England). 130: 6317-28. PMID 14623821 DOI: 10.1242/Dev.00848  0.8
2003 de Bono B, Chothia C. Exegesis: A procedure to improve gene predictions and its use to find immunoglobulin superfamily proteins in the human and mouse genomes Nucleic Acids Research. 31: 6096-6103. PMID 14576296 DOI: 10.1093/Nar/Gkg828  0.8
2003 Chothia C, Gough J, Vogel C, Teichmann SA. Evolution of the protein repertoire. Science (New York, N.Y.). 300: 1701-3. PMID 12805536 DOI: 10.1126/Science.1085371  0.8
2002 Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, ... ... Chothia C, et al. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 420: 563-73. PMID 12466851 DOI: 10.1038/Nature01266  0.8
2002 Hill EE, Morea V, Chothia C. Sequence conservation in families whose members have little or no sequence similarity: the four-helical cytokines and cytochromes. Journal of Molecular Biology. 322: 205-33. PMID 12215425 DOI: 10.1016/S0022-2836(02)00653-8  0.8
2002 Jardine O, Gough J, Chothia C, Teichmann SA. Comparison of the small molecule metabolic enzymes of Escherichia coli and Saccharomyces cerevisiae. Genome Research. 12: 916-29. PMID 12045145 DOI: 10.1101/Gr.228002  0.8
2002 Bashton M, Chothia C. The geometry of domain combination in proteins. Journal of Molecular Biology. 315: 927-39. PMID 11812158 DOI: 10.1006/Jmbi.2001.5288  0.8
2002 Gough J, Chothia C. SUPERFAMILY: HMMs representing all proteins of known structure. SCOP sequence searches, alignments and genome assignments Nucleic Acids Research. 30: 268-272. PMID 11752312 DOI: 10.1093/Nar/30.1.268  0.8
2002 Lo Conte L, Brenner SE, Hubbard TJ, Chothia C, Murzin AG. SCOP database in 2002: refinements accommodate structural genomics. Nucleic Acids Research. 30: 264-7. PMID 11752311 DOI: 10.1093/Nar/30.1.264  0.8
2001 Teichmann SA, Rison SC, Thornton JM, Riley M, Gough J, Chothia C. Small-molecule metabolism: an enzyme mosaic. Trends in Biotechnology. 19: 482-6. PMID 11711174 DOI: 10.1016/S0167-7799(01)01813-3  0.8
2001 Gough J, Karplus K, Hughey R, Chothia C. Assignment of homology to genome sequences using a library of hidden Markov models that represent all proteins of known structure Journal of Molecular Biology. 313: 903-919. PMID 11697912 DOI: 10.1006/Jmbi.2001.5080  0.8
2001 Teichmann SA, Rison SC, Thornton JM, Riley M, Gough J, Chothia C. The evolution and structural anatomy of the small molecule metabolic pathways in Escherichia coli. Journal of Molecular Biology. 311: 693-708. PMID 11518524 DOI: 10.1006/Jmbi.2001.4912  0.8
2001 Kister AE, Roytberg MA, Chothia C, Vasiliev JM, Gelfand IM. The sequence determinants of cadherin molecules Protein Science. 10: 1801-1810. PMID 11514671 DOI: 10.1110/Ps.37001  0.8
2001 Teichmann SA, Murzin AG, Chothia C. Determination of protein function, evolution and interactions by structural genomics. Current Opinion in Structural Biology. 11: 354-63. PMID 11406387 DOI: 10.1016/S0959-440X(00)00215-3  0.8
2001 Hill E, Broadbent ID, Chothia C, Pettitt J. Cadherin superfamily proteins in Caenorhabditis elegans and Drosophila melanogaster Journal of Molecular Biology. 305: 1011-1024. PMID 11162110 DOI: 10.1006/Jmbi.2000.4361  0.8
2000 Stoyanov O, Kister A, Gelfand I, Kulikowski C, Chothia C. Geometric invariant core for the CL and CH1 domains of immunoglobulin molecules Journal of Computational Biology. 7: 673-684. PMID 11153093 DOI: 10.1089/106652701446143  0.8
2000 Park J, Holm L, Heger A, Chothia C. RSDB: Representative protein sequence databases have high information content Bioinformatics. 16: 458-464. PMID 10871268 DOI: 10.1093/Bioinformatics/16.5.458  0.8
2000 Teichmann SA, Chothia C, Church GM, Park J. Fast assignment of protein structures to sequences using the intermediate sequence library PDB-ISL. Bioinformatics (Oxford, England). 16: 117-24. PMID 10842732 DOI: 10.1093/Bioinformatics/16.2.117  0.8
2000 Park J, Holm L, Chothia C. Sequence search algorithm assessment and testing toolkit (SAT) Bioinformatics. 16: 104-110. PMID 10842730 DOI: 10.1093/Bioinformatics/16.2.104  0.8
2000 Teichmann SA, Chothia C. Immunoglobulin superfamily proteins in Caenorhabditis elegans. Journal of Molecular Biology. 296: 1367-83. PMID 10698639 DOI: 10.1006/Jmbi.1999.3497  0.8
2000 Al-Lazikani B, Lesk AM, Chothia C. Canonical structures for the hypervariable regions of T cell alphabeta receptors. Journal of Molecular Biology. 295: 979-95. PMID 10656805 DOI: 10.1006/Jmbi.1999.3358  0.8
2000 Hamill SJ, Cota E, Chothia C, Clarke J. Conservation of folding and stability within a protein family: the tyrosine corner as an evolutionary cul-de-sac. Journal of Molecular Biology. 295: 641-9. PMID 10623553 DOI: 10.1006/Jmbi.1999.3360  0.8
2000 Lo Conte L, Ailey B, Hubbard TJ, Brenner SE, Murzin AG, Chothia C. SCOP: a structural classification of proteins database. Nucleic Acids Research. 28: 257-9. PMID 10592240 DOI: 10.1093/Nar/25.1.236  0.8
2000 Chothia C. The Evolution of Protein Repertoires Biochemical Society Transactions. 28. DOI: 10.1042/Bst028A107A  0.52
2000 Teichmann SA, Chothia C, Church GM, Park J. PDB_ISL: An intermediate sequence library for protein structure assignment Proceedings of the Annual International Conference On Computational Molecular Biology, Recomb. 283-289.  0.8
1999 Gerstein M, Chothia C. Proteins in motion Science. 285: 1682-1683. PMID 10523185 DOI: 10.1126/Science.285.5434.1682  0.8
1999 Tsai J, Taylor R, Chothia C, Gerstein M. The packing density in proteins: Standard radii and volumes Journal of Molecular Biology. 290: 253-266. PMID 10388571 DOI: 10.1006/Jmbi.1999.2829  0.8
1999 Teichmann SA, Chothia C, Gerstein M. Advances in structural genomics Current Opinion in Structural Biology. 9: 390-399. PMID 10361097 DOI: 10.1016/S0959-440X(99)80053-0  0.8
1999 Conte LL, Chothia C, Janin J. The atomic structure of protein-protein recognition sites Journal of Molecular Biology. 285: 2177-2198. PMID 9925793 DOI: 10.1006/Jmbi.1998.2439  0.8
1999 Bycroft M, Bateman A, Clarke J, Hamill SJ, Sandford R, Thomas RL, Chothia C. The structure of a PKD domain from polycystin-1: implications for polycystic kidney disease. The Embo Journal. 18: 297-305. PMID 9889186 DOI: 10.1093/Emboj/18.2.297  0.8
1999 Hubbard TJ, Ailey B, Brenner SE, Murzin AG, Chothia C. SCOP: a Structural Classification of Proteins database. Nucleic Acids Research. 27: 254-6. PMID 9847194 DOI: 10.1093/nar/27.1.254  0.8
1999 Teichmann S, Park J, Chothia C. Genome sequences and protein structures Proceedings of the Annual International Conference On Computational Molecular Biology, Recomb. p 1. DOI: 10.1042/Bst028A023C  0.8
1998 Hubbard TJ, Ailey B, Brenner SE, Murzin AG, Chothia C. SCOP, Structural Classification of Proteins database: applications to evaluation of the effectiveness of sequence alignment methods and statistics of protein structural data. Acta Crystallographica. Section D, Biological Crystallography. 54: 1147-54. PMID 10089491 DOI: 10.1107/S0907444998009172  0.8
1998 Teichmann SA, Parkt J, Chothia C. Structural assignments to the Mycoplasma genitalium proteins show extensive gene duplications and domain rearrangements Proceedings of the National Academy of Sciences of the United States of America. 95: 14658-14663. PMID 9843945 DOI: 10.1073/Pnas.95.25.14658  0.8
1998 Park J, Karplus K, Barrett C, Hughey R, Haussler D, Hubbard T, Chothia C. Sequence comparisons using multiple sequences detect three times as many remote homologues as pairwise methods Journal of Molecular Biology. 284: 1201-1210. PMID 9837738 DOI: 10.1006/Jmbi.1998.2221  0.8
1998 Brenner SE, Chothia C, Hubbard TJ. Assessing sequence comparison methods with reliable structurally identified distant evolutionary relationships. Proceedings of the National Academy of Sciences of the United States of America. 95: 6073-8. PMID 9600919 DOI: 10.1073/Pnas.95.11.6073  0.8
1998 Chothia C, Gelfand I, Kister A. Structural determinants in the sequences of immunoglobulin variable domain Journal of Molecular Biology. 278: 457-479. PMID 9571064 DOI: 10.1006/Jmbi.1998.1653  0.8
1998 Morea V, Tramontano A, Rustici M, Chothia C, Lesk AM. Conformations of the third hypervariable region in the VH domain of immunoglobulins. Journal of Molecular Biology. 275: 269-94. PMID 9466909 DOI: 10.1006/Jmbi.1997.1442  0.8
1997 Morea V, Tramontano A, Rustici M, Chothia C, Lesk AM. Antibody structure, prediction and redesign. Biophysical Chemistry. 68: 9-16. PMID 9468606 DOI: 10.1016/S0301-4622(96)02266-1  0.8
1997 Al-Lazikani B, Lesk AM, Chothia C. Standard conformations for the canonical structures of immunoglobulins. Journal of Molecular Biology. 273: 927-48. PMID 9367782 DOI: 10.1006/Jmbi.1997.1354  0.8
1997 Park J, Teichmann SA, Hubbard T, Chothia C. Intermediate sequences increase the detection of homology between sequences Journal of Molecular Biology. 273: 349-354. PMID 9367767 DOI: 10.1006/Jmbi.1997.1288  0.8
1997 Sandford R, Sgotto B, Aparicio S, Brenner S, Vaudin M, Wilson RK, Chissoe S, Pepin K, Bateman A, Chothia C, Hughes J, Harris P. Comparative analysis of the polycystic kidney disease 1 (PKD1) gene reveals an integral membrane glycoprotein with multiple evolutionary conserved domains Human Molecular Genetics. 6: 1483-1489. PMID 9285785 DOI: 10.1093/Hmg/6.9.1483  0.8
1997 Chothia C, Jones EY. The molecular structure of cell adhesion molecules Annual Review of Biochemistry. 66: 823-862. PMID 9242926 DOI: 10.1146/Annurev.Biochem.66.1.823  0.8
1997 Chothia C, Hubbard T, Brenner S, Barns H, Murzin A. Protein folds in the all-β and all-α classes Annual Review of Biophysics and Biomolecular Structure. 26: 597-627. PMID 9241431 DOI: 10.1146/Annurev.Biophys.26.1.597  0.8
1997 Brenner SE, Chothia C, Hubbard TJ. Population statistics of protein structures: lessons from structural classifications. Current Opinion in Structural Biology. 7: 369-76. PMID 9204279 DOI: 10.1016/S0959-440X(97)80054-1  0.8
1997 Chothia C, Gerstein M. How far can sequences diverge? Nature. 385: 579+581. PMID 9024652 DOI: 10.1038/385579A0  0.8
1996 Bateman A, Chothia C. Fibronectin type III domains in yeast detected by a hidden Markov model [2] Current Biology. 6: 1544-1547. PMID 8994808 DOI: 10.1016/S0960-9822(02)70765-3  0.8
1996 Fong S, Hamill SJ, Proctor M, Freund SM, Benian GM, Chothia C, Bycroft M, Clarke J. Structure and stability of an immunoglobulin superfamily domain from twitchin, a muscle protein of the nematode Caenorhabditis elegans. Journal of Molecular Biology. 264: 624-39. PMID 8969309 DOI: 10.1006/Jmbi.1996.0665  0.8
1996 Bateman A, Jouet M, MacFarlane J, Du JS, Kenwrick S, Chothia C. Outline structure of the human L1 cell adhesion molecule and the sites where mutations cause neurological disorders. The Embo Journal. 15: 6050-9. PMID 8947027  0.8
1996 Bateman A, Eddy SR, Chothia C. Members of the immunoglobulin superfamily in bacteria Protein Science. 5: 1939-1941. PMID 8880921 DOI: 10.1002/Pro.5560050923  0.8
1996 Gerstein M, Chothia C. Packing at the protein-water interface Proceedings of the National Academy of Sciences of the United States of America. 93: 10167-10172. PMID 8816770 DOI: 10.1073/Pnas.93.19.10167  0.8
1996 Brenner SE, Chothia C, Hubbard TJP, Murzin AG. [37] Understanding protein structure: Using scop for fold interpretation Methods in Enzymology. 266: 635-642. PMID 8743710 DOI: 10.1016/S0076-6879(96)66039-X  0.8
1996 Bateman A, Jouet M, MacFarlane J, Du JS, Kenwrick S, Chothia C. Outline Structure Of The Human L1 Cell Adhesion Molecule And The Sites Where Mutations Cause Neurological Disorders The Embo Journal. 15: 6050-6059. DOI: 10.1002/J.1460-2075.1996.Tb00993.X  0.6
1995 Bateman A, Chothia C. Outline structures for the extracellular domains of the fibroblast growth factor receptors Nature Structural Biology. 2: 1068-1074. PMID 8846218 DOI: 10.1038/Nsb1295-1068  0.8
1995 Murzin AG, Brenner SE, Hubbard T, Chothia C. SCOP: A structural classification of proteins database for the investigation of sequences and structures Journal of Molecular Biology. 247: 536-540. PMID 7723011 DOI: 10.1016/S0022-2836(05)80134-2  0.8
1995 Tomlinson IM, Cox JP, Gherardi E, Lesk AM, Chothia C. The structural repertoire of the human V kappa domain. The Embo Journal. 14: 4628-38. PMID 7556106 DOI: 10.1002/J.1460-2075.1995.Tb00142.X  0.8
1995 Brenner SE, Hubbard T, Murzin A, Chothia C. Gene duplications in H. influenzae [7] Nature. 378: 140. PMID 7477316 DOI: 10.1038/378140A0  0.8
1994 Gerstein M, Lesk AM, Chothia C. Structural mechanisms for domain movements in proteins. Biochemistry. 33: 6739-49. PMID 8204609 DOI: 10.1021/Bi00188A001  0.8
1994 Harpaz Y, Chothia C. Many of the immunoglobulin superfamily domains in cell adhesion molecules and surface receptors belong to a new structural set which is close to that containing variable domains Journal of Molecular Biology. 238: 528-539. PMID 8176743 DOI: 10.1006/Jmbi.1994.1312  0.8
1994 Murzin AG, Lesk AM, Chothia C. Principles determining the structure of beta-sheet barrels in proteins. II. The observed structures. Journal of Molecular Biology. 236: 1382-400. PMID 8126727 DOI: 10.1016/0022-2836(94)90065-5  0.8
1994 Murzin AG, Lesk AM, Chothia C. Principles determining the structure of beta-sheet barrels in proteins. I. A theoretical analysis. Journal of Molecular Biology. 236: 1369-81. PMID 8126726 DOI: 10.1016/0022-2836(94)90064-7  0.8
1994 Gerstein M, Sonnhammer ELL, Chothia C. Volume changes in protein evolution Journal of Molecular Biology. 236: 1067-1078. PMID 8120887 DOI: 10.1016/0022-2836(94)90012-4  0.8
1994 Harpaz Y, Gerstein M, Chothia C. Volume changes on protein folding Structure. 2: 641-649. PMID 7922041 DOI: 10.1016/S0969-2126(00)00065-4  0.8
1994 Barré S, Greenberg AS, Flajnik MF, Chothia C. Structural conservation of hypervariable regions in immunoglobulins evolution. Nature Structural Biology. 1: 915-20. PMID 7773781 DOI: 10.1038/Nsb1294-915  0.8
1994 Chothia C, Taylor WR. Editorial overview Current Opinion in Structural Biology. 4: 381-382. DOI: 10.1016/S0959-440X(94)90107-4  0.8
1994 Chothia C. Protein families in the metazoan genome Development. 120: 27-33.  0.8
1993 Gerstein M, Schulz G, Chothia C. Domain closure in adenylate kinase. Joints on either side of two helices close like neighboring fingers Journal of Molecular Biology. 229: 494-501. PMID 8429559 DOI: 10.1006/Jmbi.1993.1048  0.8
1993 Gerstein M, Anderson BF, Norris GE, Baker EN, Lesk AM, Chothia C. Domain closure in lactoferrin. Two hinges produce a see-saw motion between alternative close-packed interfaces. Journal of Molecular Biology. 234: 357-72. PMID 8230220 DOI: 10.1006/Jmbi.1993.1592  0.8
1993 Chothia C, Murzin AG. New folds for all-β proteins Structure. 1: 217-222. PMID 8081735 DOI: 10.1016/0969-2126(93)90010-E  0.8
1992 Murzin AG, Lesk AM, Chothia C. beta-Trefoil fold. Patterns of structure and sequence in the Kunitz inhibitors interleukins-1 beta and 1 alpha and fibroblast growth factors. Journal of Molecular Biology. 223: 531-43. PMID 1738162 DOI: 10.1016/0022-2836(92)90668-A  0.8
1992 Chothia C. One thousand families for the molecular biologist Nature. 357: 543-544. PMID 1608464 DOI: 10.1038/357543A0  0.8
1992 McPhalen CA, Vincent MG, Picot D, Jansonius JN, Lesk AM, Chothia C. Domain closure in mitochondrial aspartate aminotransferase. Journal of Molecular Biology. 227: 197-213. PMID 1522585 DOI: 10.1016/0022-2836(92)90691-C  0.8
1992 Chothia C, Lesk AM, Gherardi E, Tomlinson IM, Walter G, Marks JD, Llewelyn MB, Winter G. Structural repertoire of the human VH segments. Journal of Molecular Biology. 227: 799-817. PMID 1404389 DOI: 10.1016/0022-2836(92)90224-8  0.8
1992 Murzin AG, Chothia C. Protein architecture: new superfamilies Current Opinion in Structural Biology. 2: 895-903. DOI: 10.1016/0960-9822(92)90106-K  0.8
1991 Gerstein M, Chothia C. Analysis of protein loop closure. Two types of hinges produce one motion in lactate dehydrogenase Journal of Molecular Biology. 220: 133-149. PMID 2067013 DOI: 10.1016/0022-2836(91)90387-L  0.8
1991 Stein P, Chothia C. Serpin tertiary structure transformation Journal of Molecular Biology. 221: 615-621. PMID 1920436 DOI: 10.1016/0022-2836(91)80076-7  0.8
1991 Chothia C. Asymmetry in protein structures Ciba Foundation Symposium. 162: 36-49; discussion 49. PMID 1802649  0.8
1991 Chothia C. Antigen recognition: Current opinion in structural biology 1991, 1:53–59 Current Opinion in Structural Biology. 1: 53-59. DOI: 10.1016/0959-440X(91)90011-H  0.52
1990 Tramontano A, Chothia C, Lesk AM. Framework residue 71 is a major determinant of the position and conformation of the second hypervariable region in the VH domains of immunoglobulins. Journal of Molecular Biology. 215: 175-82. PMID 2118959 DOI: 10.1016/S0022-2836(05)80102-0  0.8
1990 Tramontane A, Chothia C, Lesk A. Conformations of loops in immunoglobulins and other proteins Journal of Molecular Graphics. 8: 232-233. DOI: 10.1016/0263-7855(90)80020-G  0.52
1989 Chothia C. Polyhedra for helical proteins. Nature. 337: 204-205. PMID 2911358 DOI: 10.1038/337204A0  0.32
1989 Creighton TE, Chothia C. Protein structure. Selecting buried residues. Nature. 339: 14-5. PMID 2716825 DOI: 10.1038/339014A0  0.8
1989 Chothia C, Lesk AM, Tramontano A, Levitt M, Smith-Gill SJ, Air G, Sheriff S, Padlan EA, Davies D, Tulip WR. Conformations of immunoglobulin hypervariable regions. Nature. 342: 877-83. PMID 2687698 DOI: 10.1038/342877A0  0.8
1989 Lesk AM, Brändén CI, Chothia C. Structural principles of alpha/beta barrel proteins: the packing of the interior of the sheet. Proteins. 5: 139-48. PMID 2664768 DOI: 10.1002/Prot.340050208  0.8
1989 Tramontano A, Chothia C, Lesk AM. Structural determinants of the conformations of medium-sized loops in proteins. Proteins. 6: 382-94. PMID 2622909 DOI: 10.1002/Prot.340060405  0.8
1988 Lesk AM, Chothia C. Elbow motion in the immunoglobulins involves a molecular ball-and-socket joint. Nature. 335: 188-90. PMID 3412476 DOI: 10.1038/335188A0  0.8
1988 Janin J, Miller S, Chothia C. Surface, subunit interfaces and interior of oligomeric proteins Journal of Molecular Biology. 204: 155-164. PMID 3216390 DOI: 10.1016/0022-2836(88)90606-7  0.8
1988 Chothia C, Boswell DR, Lesk AM. The outline structure of the T-cell alpha beta receptor. The Embo Journal. 7: 3745-55. PMID 3208747 DOI: 10.1002/J.1460-2075.1988.Tb03258.X  0.8
1987 Chothia C, Lesk AM. Canonical structures for the hypervariable regions of immunoglobulins. Journal of Molecular Biology. 196: 901-17. PMID 3681981 DOI: 10.1016/0022-2836(87)90412-8  0.8
1987 Miller S, Janin J, Lesk AM, Chothia C. Interior and surface of monomeric proteins. Journal of Molecular Biology. 196: 641-56. PMID 3681970 DOI: 10.1016/0022-2836(87)90038-6  0.8
1987 Bashford D, Chothia C, Lesk AM. Determinants of a protein fold. Unique features of the globin amino acid sequences. Journal of Molecular Biology. 196: 199-216. PMID 3656444 DOI: 10.1016/0022-2836(87)90521-3  0.8
1987 Miller S, Lesk AM, Janin J, Chothia C. The accessible surface area and stability of oligomeric proteins. Nature. 328: 834-6. PMID 3627230 DOI: 10.1038/328834A0  0.8
1987 Chothia C, Lesk AM. The evolution of protein structures. Cold Spring Harbor Symposia On Quantitative Biology. 52: 399-405. PMID 3454269 DOI: 10.1101/Sqb.1987.052.01.046  0.8
1986 Janin J, Chothia C. Domains in proteins: definitions, location, and structural principles. Methods in Enzymology. 115: 420-30. PMID 4079796 DOI: 10.1016/0076-6879(85)15030-5  0.8
1986 Chothia C, Lesk AM. The relation between the divergence of sequence and structure in proteins. The Embo Journal. 5: 823-6. PMID 3709526 DOI: 10.1002/J.1460-2075.1986.Tb04288.X  0.8
1986 Lesk AM, Levitt M, Chothia C. Alignment of the amino acid sequences of distantly related proteins using variable gap penalties. Protein Engineering. 1: 77-8. PMID 3507691 DOI: 10.1093/Protein/1.1.77  0.8
1986 Chothia C, Lesk AM, Levitt M, Amit AG, Mariuzza RA, Phillips SE, Poljak RJ. The predicted structure of immunoglobulin D1.3 and its comparison with the crystal structure. Science (New York, N.Y.). 233: 755-8. PMID 3090684 DOI: 10.1126/Science.3090684  0.8
1986 Lesk AM, Chothia C. Modelling of related proteins Journal of Molecular Graphics. 4: 180. DOI: 10.1016/0263-7855(86)80025-X  0.52
1985 Lesk AM, Janin J, Wodak S, Chothia C. Haemoglobin: The surface buried between the α1β1 and α2β2 dimers in the deoxy and oxy structures Journal of Molecular Biology. 183: 267-270. PMID 4009726 DOI: 10.1016/0022-2836(85)90219-0  0.8
1985 Chothia C, Lesk AM. Helix movements and the reconstruction of the haem pocket during the evolution of the cytochrome c family Journal of Molecular Biology. 182: 151-158. PMID 2987508 DOI: 10.1016/0022-2836(85)90033-6  0.8
1985 Chothia C, Lesk AM. Helix movements in proteins Trends in Biochemical Sciences. 10: 116-118. DOI: 10.1016/0968-0004(85)90270-1  0.8
1984 Chothia C. Principles that determine the structure of proteins Annual Review of Biochemistry. 53: 537-572. PMID 6383199 DOI: 10.1146/Annurev.Bi.53.070184.002541  0.4
1984 Lesk AM, Chothia C. Mechanisms of domain closure in proteins Journal of Molecular Biology. 174: 175-191. PMID 6371249 DOI: 10.1016/0022-2836(84)90371-1  0.8
1983 Chothia C, Lesk AM, Dodson GG, Hodgkin DC. Transmission of conformational change in insulin Nature. 302: 500-505. PMID 6339948 DOI: 10.1038/302500A0  0.8
1982 Lesk AM, Chothia C. Evolution of proteins formed by β-sheets. II. The core of the immunoglobulin domains Journal of Molecular Biology. 160: 325-342. PMID 7175935 DOI: 10.1016/0022-2836(82)90179-6  0.8
1982 Mauguen Y, Hartley RW, Dodson EJ, Dodson GG, Bricogne G, Chothia C, Jack A. Molecular structure of a new family of ribonucleases. Nature. 297: 162-4. PMID 7078632 DOI: 10.1038/297162A0  0.8
1982 Chothia C, Lesk AM. Evolution of proteins formed by β-sheets. I. Plastocyanin and azurin Journal of Molecular Biology. 160: 309-323. PMID 6816943 DOI: 10.1016/0022-2836(82)90178-4  0.8
1982 Chothia C, Janin J. Orthogonal packing of beta-pleated sheets in proteins. Biochemistry. 21: 3955-65. PMID 6751382 DOI: 10.1021/Bi00260A009  0.84
1981 Chothia C, Janin J. Relative orientation of close-packed beta-pleated sheets in proteins. Proceedings of the National Academy of Sciences of the United States of America. 78: 4146-4150. PMID 16593054 DOI: 10.1073/Pnas.78.7.4146  0.72
1981 Chothia C, Levitt M, Richardson D. Helix to helix packing in proteins Journal of Molecular Biology. 145: 215-250. PMID 7265198 DOI: 10.1016/0022-2836(81)90341-7  0.52
1980 Lesk AM, Chothia C. How different amino acid sequences determine similar protein structures: The structure and evolutionary dynamics of the globins Journal of Molecular Biology. 136: 225-230,IN1-IN2,231-. PMID 7373651 DOI: 10.1016/0022-2836(80)90373-3  0.8
1980 Lesk AM, Chothia C. Solvent accessibility, protein surfaces, and protein folding Biophysical Journal. 32: 35-47. PMID 7248454 DOI: 10.1016/S0006-3495(80)84914-9  0.8
1980 Janin J, Chothia C. Packing of α-Helices onto β-Pleated sheets and the anatomy of αβ proteins☆ Journal of Molecular Biology. 143: 95-128. PMID 7003165 DOI: 10.1016/0022-2836(80)90126-6  0.72
1978 Janin J, Chothia C. Role of hydrophobicity in the binding of coenzymes. Appendix. Translational and rotational contribution to the free energy of dissociation. Biochemistry. 17: 2943-8. PMID 212096 DOI: 10.1021/Bi00608A001  0.76
1977 Chothia C, Wodak S, Janin J. Role of subunit interfaces in the allosteric mechanism of hemoglobin. Proceedings of the National Academy of Sciences of the United States of America. 73: 3793-7. PMID 1069263 DOI: 10.1073/Pnas.73.11.3793  0.52
1977 Chothia C, Levitt M, Richardson D. Structure of proteins: packing of alpha-helices and pleated sheets. Proceedings of the National Academy of Sciences of the United States of America. 74: 4130-4134. PMID 270659 DOI: 10.1073/Pnas.74.10.4130  0.52
1976 Chothia C. The nature of the accessible and buried surfaces in proteins Journal of Molecular Biology. 105: 1-12. PMID 994183 DOI: 10.1016/0022-2836(76)90191-1  0.4
1976 Chothia C, Baker RW, Pauling P. Conformation of acetylcholine at muscarinic nerve receptors: crystal and molecular structure of 2-trimethylammoniummethyl-5-methyl furan iodide (5-methylfurmethide iodide). Journal of Molecular Biology. 105: 517-526. PMID 972394 DOI: 10.1016/0022-2836(76)90232-1  0.32
1976 Janin J, Chothia C. Stability and specificity of protein-protein interactions: the case of the trypsin-trypsin inhibitor complexes. Journal of Molecular Biology. 100: 197-211. PMID 943547 DOI: 10.1016/S0022-2836(76)80148-9  0.56
1976 Levitt M, Chothia C. Structural patterns in globular proteins. Nature. 261: 552-8. PMID 934293 DOI: 10.1038/261552A0  0.6
1975 Chothia C, Janin J. Principles of protein–protein recognition Nature. 256: 705-708. PMID 1153006 DOI: 10.1038/256705A0  0.72
1975 Chothia C. Structural invariants in protein folding. Nature. 254: 304-308. PMID 1118010 DOI: 10.1038/254304A0  0.44
1974 Chothia C. Hydrophobic bonding and accessible surface area in proteins. Nature. 248: 338-339. PMID 4819639 DOI: 10.1038/248338A0  0.36
1974 Sweet RM, Wright HT, Janin J, Chothia CH, Blow DM. Crystal structure of the complex of porcine trypsin with soybean trypsin inhibitor (Kunitz) at 2.6-A resolution. Biochemistry. 13: 4212-28. PMID 4472048 DOI: 10.1021/Bi00717A024  0.8
1973 Chothia C. Conformation of twisted β-pleated sheets in proteins Journal of Molecular Biology. 75: 295-302. PMID 4728692 DOI: 10.1016/0022-2836(73)90022-3  0.44
1972 Baker RW, Chothia C, Pauling P, Weber HP. Molecular Structure of LSD Science. 178: 614-615. PMID 5086393 DOI: 10.1126/Science.178.4061.614  0.32
1971 Baker RW, Chothia CH, Pauling P, Petcher TJ. Structure and activity of muscarinic stimulants. Nature. 230: 439-45. PMID 4324858 DOI: 10.1038/230439A0  0.8
1971 Baker RW, Chothia CH, Pauling P, Petcher TJ. Struktur Und Aktivitaet Von Muscarinischen Stimulantien Cheminform. 2. DOI: 10.1002/Chin.197130098  0.32
1970 Chothia C. Structure Activity Relationships of some Muscarinic Agonists: a Reply to Shefter and Triggle Nature. 227: 1355-1356. PMID 5455144 DOI: 10.1038/2271355A0  0.36
1970 Chothia C, Pauling P. Biological Sciences: Absolute Configuration of Cholinergic Molecules; the Crystal Structure of (+)- trans -2-Acetoxy Cyclopropyl Trimethylammonium Iodide Nature. 226: 541-542. PMID 5442347 DOI: 10.1038/226541A0  0.32
1970 Chothia C, Pauling P. The conformation of cholinergic molecules at nicotinic nerve receptors. Proceedings of the National Academy of Sciences of the United States of America. 65: 477-482. PMID 5267133 DOI: 10.1073/Pnas.65.3.477  0.52
1969 Chothia C, Pauling P. Conformation of cholinergic molecules relevant to acetylcholinesterase. Nature. 223: 919-921. PMID 5803395 DOI: 10.1038/223919A0  0.32
1969 Chothia C, Pauling P. On The Conformations Of Hallucinogenic Molecules And Their Correlation Proceedings of the National Academy of Sciences of the United States of America. 63: 1063-1070. PMID 4311249 DOI: 10.1073/Pnas.63.4.1063  0.52
1969 Chothia C, Pauling P. Two conformations of the cholinergic agonist acetyl-α-methylcholine: a new conformation of cholinergic molecules Journal of the Chemical Society D: Chemical Communications. 746-747. DOI: 10.1039/C29690000746  0.52
1969 Chothia C, Pauling P. The structure of the potent muscarinic agonist L-(+)-acetyl-β-methylcholine iodide Journal of the Chemical Society D: Chemical Communications. 626-627. DOI: 10.1039/C29690000626  0.52
1968 Chothia C, Pauling P. Conformations of Acetylcholine Nature. 219: 1156-1157. PMID 5675631 DOI: 10.1038/2191156A0  0.32
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