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Andrew D. Miranker - Publications

Affiliations: 
Molecular Biophysics and Biochemistry Yale University, New Haven, CT 
Area:
Protein Folding and Dynamics, Structural Biology
Website:
http://medicine.yale.edu/mbb/faculty/andrew_miranker.profile

78 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Wójcik S, Birol M, Rhoades E, Miranker AD, Levine ZA. Targeting the Intrinsically Disordered Proteome Using Small-Molecule Ligands. Methods in Enzymology. 611: 703-734. PMID 30471705 DOI: 10.1016/Bs.Mie.2018.09.036  0.317
2018 Birol M, Kumar S, Rhoades E, Miranker AD. Conformational switching within dynamic oligomers underpins toxic gain-of-function by diabetes-associated amyloid. Nature Communications. 9: 1312. PMID 29615609 DOI: 10.1038/S41467-018-03651-9  0.463
2017 Birol M, Kumar S, Rhoades E, Miranker A. Toxic and Non-Toxic Forms of Membrane Poration are Mediated by Structurally Distinct States of Islet Amyloid Polypeptide Biophysical Journal. 112: 503a. DOI: 10.1016/J.Bpj.2016.11.2724  0.449
2016 Kumar S, Birol M, Schlamadinger DE, Wojcik SP, Rhoades E, Miranker AD. Foldamer-mediated manipulation of a pre-amyloid toxin. Nature Communications. 7: 11412. PMID 27108700 DOI: 10.1038/Ncomms11412  0.5
2016 Kumar S, Birol M, Miranker AD. Foldamer scaffolds suggest distinct structures are associated with alternative gains-of-function in a preamyloid toxin. Chemical Communications (Cambridge, England). PMID 27079937 DOI: 10.1039/C6Cc01248E  0.401
2016 Junghans A, Watkins EB, Majewski J, Miranker AD, Stroe I. Influence of the Human and Rat Islet Amyloid Polypeptides on Structure of Phospholipid Bilayers: Neutron Reflectometry and Fluorescence Microscopy Studies. Langmuir : the Acs Journal of Surfaces and Colloids. PMID 27065348 DOI: 10.1021/Acs.Langmuir.6B00825  0.502
2016 Khemtemourian L, Gazit E, Miranker A. Recent Insight in Islet Amyloid Polypeptide Morphology, Structure, Membrane Interaction, and Toxicity in Type 2 Diabetes. Journal of Diabetes Research. 2016: 2535878. PMID 26770986 DOI: 10.1155/2016/2535878  0.366
2015 White EM, Miranker AD. A solenoid design for assessing determinants of parallel β-sheet registration. Protein Engineering, Design & Selection : Peds. PMID 26487712 DOI: 10.1093/Protein/Gzv053  0.35
2015 Witten J, Ruschak A, Poterba T, Jaramillo A, Miranker AD, Jaswal SS. Mapping Protein Conformational Landscapes under Strongly Native Conditions with Hydrogen Exchange Mass Spectrometry. The Journal of Physical Chemistry. B. 119: 10016-24. PMID 26146955 DOI: 10.1021/Acs.Jpcb.5B04528  0.789
2015 Nath A, Schlamadinger DE, Rhoades E, Miranker AD. Structure-Based Small Molecule Modulation of a Pre-Amyloid State: Pharmacological Enhancement of IAPP Membrane-Binding and Toxicity. Biochemistry. 54: 3555-64. PMID 25966003 DOI: 10.1021/Acs.Biochem.5B00052  0.444
2015 Kumar S, Schlamadinger DE, Brown MA, Dunn JM, Mercado B, Hebda JA, Saraogi I, Rhoades E, Hamilton AD, Miranker AD. Islet amyloid-induced cell death and bilayer integrity loss share a molecular origin targetable with oligopyridylamide-based α-helical mimetics. Chemistry & Biology. 22: 369-78. PMID 25754474 DOI: 10.1016/J.Chembiol.2015.01.006  0.794
2015 Rubio MA, Schlamadinger DE, White EM, Miranker AD. Peptide amyloid surface display. Biochemistry. 54: 987-93. PMID 25541905 DOI: 10.1021/Bi5011442  0.662
2015 Kulikov OV, Kumar S, Magzoub M, Knipe PC, Saraogi I, Thompson S, Miranker AD, Hamilton AD. Amphiphilic oligoamide α-helix peptidomimetics inhibit islet amyloid polypeptide aggregation Tetrahedron Letters. DOI: 10.1016/J.Tetlet.2015.02.132  0.499
2015 Brown MA, Rhoades E, Miranker AD. A Role for Unstructured Residues in the Induction of Membrane Poration by Pre-Amyloid Assemblies of Islet Amyloid Polypeptide Biophysical Journal. 108: 496a. DOI: 10.1016/J.Bpj.2014.11.2712  0.486
2015 Kumar S, Schlamadinger D, Miranker A. Foldamer-Based Enantioselective Targeting of Islet Amyloid Polypeptide Biophysical Journal. 108: 217a. DOI: 10.1016/J.Bpj.2014.11.1198  0.553
2014 Schlamadinger DE, Miranker AD. Fiber-dependent and -independent toxicity of islet amyloid polypeptide. Biophysical Journal. 107: 2559-66. PMID 25468335 DOI: 10.1016/J.Bpj.2014.09.047  0.494
2014 Hebda JA, Magzoub M, Miranker AD. Small molecule screening in context: lipid-catalyzed amyloid formation. Protein Science : a Publication of the Protein Society. 23: 1341-8. PMID 25043951 DOI: 10.1002/Pro.2518  0.82
2014 Kumar S, Brown MA, Nath A, Miranker AD. Folded small molecule manipulation of islet amyloid polypeptide. Chemistry & Biology. 21: 775-81. PMID 24930968 DOI: 10.1016/J.Chembiol.2014.05.007  0.497
2014 Rubio M, Miranker AD. Surface-Catalyzed Nucleation of Amyloidogenic Peptides by Peptide-Specific Templates Biophysical Journal. 106: 39a. DOI: 10.1016/J.Bpj.2013.11.293  0.683
2013 Last NB, Schlamadinger DE, Miranker AD. A common landscape for membrane-active peptides. Protein Science : a Publication of the Protein Society. 22: 870-82. PMID 23649542 DOI: 10.1002/Pro.2274  0.782
2013 Kumar S, Miranker AD. A foldamer approach to targeting membrane bound helical states of islet amyloid polypeptide. Chemical Communications (Cambridge, England). 49: 4749-51. PMID 23579860 DOI: 10.1039/C3Cc41452C  0.498
2013 Last NB, Miranker AD. Common mechanism unites membrane poration by amyloid and antimicrobial peptides. Proceedings of the National Academy of Sciences of the United States of America. 110: 6382-7. PMID 23576726 DOI: 10.1073/Pnas.1219059110  0.795
2013 Nath A, Schlamadinger DE, Dodhia S, Rhoades E, Miranker AD. Screening and Design of New Modulators of IAPP Membrane-Binding and Toxicity Biophysical Journal. 104: 56a-57a. DOI: 10.1016/J.Bpj.2012.11.351  0.494
2013 Schlamadinger DE, Kumar S, Magzoub M, Hebda JA, Miranker AD. Inhibition and Mechanism of Islet Amyloid Polypeptide Toxicity Biophysical Journal. 104: 56a. DOI: 10.1016/J.Bpj.2012.11.350  0.809
2013 Dodhia S, Nath A, Miranker AD. Design and Characterization of Peptide Modulators of IAPP-Membrane Binding Biophysical Journal. 104: 592a. DOI: 10.1016/J.Bpj.2012.11.3288  0.463
2013 Dunn JM, Miranker AD, Rhoades E. Membrane Geometry Alters the Interaction between Islet Amyloid Polypeptide and Lipid Bilayers Biophysical Journal. 104: 592a. DOI: 10.1016/J.Bpj.2012.11.3287  0.424
2013 White EM, Kishore Inampudi K, Wilson CJ, Miranker AD. Designing Self Assembling Beta Helices Biophysical Journal. 104: 568a-569a. DOI: 10.1016/J.Bpj.2012.11.3155  0.438
2013 Kumar S, Schlamadinger DE, Miranker A. Targeting Protein Misfolding(Islet Amyloid Polypeptide) using Helical Mimetics Biophysical Journal. 104: 379a. DOI: 10.1016/J.Bpj.2012.11.2112  0.505
2012 Magzoub M, Miranker AD. Concentration-dependent transitions govern the subcellular localization of islet amyloid polypeptide. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 1228-38. PMID 22183778 DOI: 10.1096/Fj.11-194613  0.456
2011 Nath A, Miranker AD, Rhoades E. A membrane-bound antiparallel dimer of rat islet amyloid polypeptide. Angewandte Chemie (International Ed. in English). 50: 10859-62. PMID 21948544 DOI: 10.1002/Anie.201102887  0.442
2011 Last NB, Rhoades E, Miranker AD. Islet amyloid polypeptide demonstrates a persistent capacity to disrupt membrane integrity. Proceedings of the National Academy of Sciences of the United States of America. 108: 9460-5. PMID 21606325 DOI: 10.1073/Pnas.1102356108  0.817
2011 Magzoub M, Miranker AD. Protein aggregation: p53 succumbs to peer pressure. Nature Chemical Biology. 7: 248-9. PMID 21502944 DOI: 10.1038/Nchembio.569  0.328
2011 Nath A, O'Hern C, Miranker AD, Rhoades E. Single molecule studies of unstructured protein function and dynamics Optics Infobase Conference Papers. DOI: 10.1364/Fio.2011.Ftuh1  0.341
2011 Last NB, Rhoades E, Miranker AD. Evolution of Membrane Leakage by Pre-Amyloidogenic Oligomers of Islet Amyloid Polypeptide Biophysical Journal. 100: 350a. DOI: 10.1016/J.Bpj.2010.12.2110  0.495
2010 Wolfe LS, Calabrese MF, Nath A, Blaho DV, Miranker AD, Xiong Y. Protein-induced photophysical changes to the amyloid indicator dye thioflavin T. Proceedings of the National Academy of Sciences of the United States of America. 107: 16863-8. PMID 20826442 DOI: 10.1073/Pnas.1002867107  0.777
2010 Nath A, Trexler AJ, Koo P, Miranker AD, Atkins WM, Rhoades E. Single-molecule fluorescence spectroscopy using phospholipid bilayer nanodiscs. Methods in Enzymology. 472: 89-117. PMID 20580961 DOI: 10.1016/S0076-6879(10)72014-0  0.382
2010 Saraogi I, Hebda JA, Becerril J, Estroff LA, Miranker AD, Hamilton AD. Synthetic alpha-helix mimetics as agonists and antagonists of islet amyloid polypeptide aggregation. Angewandte Chemie (International Ed. in English). 49: 736-9. PMID 20029853 DOI: 10.1002/Anie.200901694  0.807
2010 Nath A, Miranker AD, Rhoades E. Pre-Amyloid States of Islet Amyloid Polypeptide Examined by Single-Particle Fluorescence Biophysical Journal. 98: 650a-651a. DOI: 10.1016/J.Bpj.2009.12.3566  0.52
2010 Magzoub M, Hebda JA, Miranker A. Small Molecule Inhibitors of Islet Amyloid Polypeptide Fibrillogenesis and Cytotoxicity Biophysical Journal. 98: 255a. DOI: 10.1016/J.Bpj.2009.12.1387  0.838
2009 Hebda JA, Saraogi I, Magzoub M, Hamilton AD, Miranker AD. A peptidomimetic approach to targeting pre-amyloidogenic states in type II diabetes. Chemistry & Biology. 16: 943-50. PMID 19778722 DOI: 10.1016/J.Chembiol.2009.08.013  0.82
2009 Williamson JA, Loria JP, Miranker AD. Helix stabilization precedes aqueous and bilayer-catalyzed fiber formation in islet amyloid polypeptide. Journal of Molecular Biology. 393: 383-96. PMID 19647750 DOI: 10.1016/J.Jmb.2009.07.077  0.733
2009 Ruschak AM, Miranker AD. The role of prefibrillar structures in the assembly of a peptide amyloid. Journal of Molecular Biology. 393: 214-26. PMID 19524594 DOI: 10.1016/J.Jmb.2009.06.026  0.83
2009 Blaho DV, Miranker AD. Delineating the conformational elements responsible for Cu(2+)-induced oligomerization of beta-2 microglobulin. Biochemistry. 48: 6610-7. PMID 19518133 DOI: 10.1021/Bi900540J  0.791
2009 Hebda JA, Miranker AD. The interplay of catalysis and toxicity by amyloid intermediates on lipid bilayers: insights from type II diabetes. Annual Review of Biophysics. 38: 125-52. PMID 19416063 DOI: 10.1146/Annurev.Biophys.050708.133622  0.827
2009 Calabrese MF, Miranker AD. Metal binding sheds light on mechanisms of amyloid assembly. Prion. 3: 1-4. PMID 19377278 DOI: 10.4161/Pri.3.1.8601  0.76
2009 Last NB, Rhoades E, Miranker AD. Single Particle Analysis of Liposome Leakage Induced by Islet Amyloid Polypeptide Biophysical Journal. 96: 158a. DOI: 10.1016/J.Bpj.2008.12.718  0.472
2008 Calabrese MF, Eakin CM, Wang JM, Miranker AD. A regulatable switch mediates self-association in an immunoglobulin fold. Nature Structural & Molecular Biology. 15: 965-71. PMID 19172750 DOI: 10.1038/Nsmb.1483  0.813
2008 Knight JD, Williamson JA, Miranker AD. Interaction of membrane-bound islet amyloid polypeptide with soluble and crystalline insulin. Protein Science : a Publication of the Protein Society. 17: 1850-6. PMID 18765820 DOI: 10.1110/Ps.036350.108  0.75
2008 Koo BW, Hebda JA, Miranker AD. Amide inequivalence in the fibrillar assembly of islet amyloid polypeptide. Protein Engineering, Design & Selection : Peds. 21: 147-54. PMID 18299291 DOI: 10.1093/Protein/Gzm076  0.821
2007 Jaswal SS, Miranker AD. Scope and utility of hydrogen exchange as a tool for mapping landscapes. Protein Science : a Publication of the Protein Society. 16: 2378-90. PMID 17962401 DOI: 10.1110/Ps.072994207  0.328
2007 Ruschak AM, Miranker AD. Fiber-dependent amyloid formation as catalysis of an existing reaction pathway. Proceedings of the National Academy of Sciences of the United States of America. 104: 12341-6. PMID 17640888 DOI: 10.1073/Pnas.0703306104  0.819
2007 Calabrese MF, Miranker AD. Formation of a stable oligomer of beta-2 microglobulin requires only transient encounter with Cu(II). Journal of Molecular Biology. 367: 1-7. PMID 17254602 DOI: 10.1016/J.Jmb.2006.12.034  0.779
2007 Williamson JA, Miranker AD. Direct detection of transient alpha-helical states in islet amyloid polypeptide. Protein Science : a Publication of the Protein Society. 16: 110-7. PMID 17123962 DOI: 10.1110/Ps.062486907  0.697
2007 Williamson J, Miranker A. Backbone 1H, 13C, and 15N and CB Assignments for Rat Islet Amyloid Polypeptide Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr7311  0.578
2006 Knight JD, Hebda JA, Miranker AD. Conserved and cooperative assembly of membrane-bound alpha-helical states of islet amyloid polypeptide. Biochemistry. 45: 9496-508. PMID 16878984 DOI: 10.1021/Bi060579Z  0.833
2006 Eakin CM, Berman AJ, Miranker AD. A native to amyloidogenic transition regulated by a backbone trigger. Nature Structural & Molecular Biology. 13: 202-8. PMID 16491088 DOI: 10.1038/Nsmb1068  0.753
2005 Eakin CM, Miranker AD. From chance to frequent encounters: origins of beta2-microglobulin fibrillogenesis. Biochimica Et Biophysica Acta. 1753: 92-9. PMID 16226064 DOI: 10.1016/J.Bbapap.2005.09.002  0.745
2005 Miranker AD. Structural biology: fibres hinge on swapped domains. Nature. 437: 197-8. PMID 16148916 DOI: 10.1038/437197A  0.328
2005 Miranker AD. Quantitative measurement of fibrillogenesis by mass spectrometry. Methods in Molecular Biology (Clifton, N.J.). 299: 185-94. PMID 15980602 DOI: 10.1385/1-59259-874-9:185  0.444
2005 Koo BW, Miranker AD. Contribution of the intrinsic disulfide to the assembly mechanism of islet amyloid. Protein Science : a Publication of the Protein Society. 14: 231-9. PMID 15576552 DOI: 10.1110/Ps.041051205  0.74
2004 Knight JD, Miranker AD. Phospholipid catalysis of diabetic amyloid assembly. Journal of Molecular Biology. 341: 1175-87. PMID 15321714 DOI: 10.1016/J.Jmb.2004.06.086  0.701
2004 Eakin CM, Attenello FJ, Morgan CJ, Miranker AD. Oligomeric assembly of native-like precursors precedes amyloid formation by beta-2 microglobulin. Biochemistry. 43: 7808-15. PMID 15196023 DOI: 10.1021/Bi049792Q  0.75
2004 Miranker AD. Unzipping the mysteries of amyloid fiber formation. Proceedings of the National Academy of Sciences of the United States of America. 101: 4335-6. PMID 15070716 DOI: 10.1073/Pnas.0401163101  0.537
2004 Larson JL, Miranker AD. The mechanism of insulin action on islet amyloid polypeptide fiber formation. Journal of Molecular Biology. 335: 221-31. PMID 14659752 DOI: 10.1016/J.Jmb.2003.10.045  0.413
2002 Eakin CM, Knight JD, Morgan CJ, Gelfand MA, Miranker AD. Formation of a copper specific binding site in non-native states of beta-2-microglobulin. Biochemistry. 41: 10646-56. PMID 12186550 DOI: 10.1021/Bi025944A  0.755
2002 Padrick SB, Miranker AD. Islet amyloid: phase partitioning and secondary nucleation are central to the mechanism of fibrillogenesis. Biochemistry. 41: 4694-703. PMID 11926832 DOI: 10.1021/Bi0160462  0.759
2001 Morgan CJ, Gelfand M, Atreya C, Miranker AD. Kidney dialysis-associated amyloidosis: a molecular role for copper in fiber formation. Journal of Molecular Biology. 309: 339-45. PMID 11371157 DOI: 10.1006/Jmbi.2001.4661  0.468
2001 Padrick SB, Miranker AD. Islet amyloid polypeptide: identification of long-range contacts and local order on the fibrillogenesis pathway. Journal of Molecular Biology. 308: 783-94. PMID 11350174 DOI: 10.1006/Jmbi.2001.4608  0.79
2000 Miranker AD. Protein complexes and analysis of their assembly by mass spectrometry. Current Opinion in Structural Biology. 10: 601-6. PMID 11042460 DOI: 10.1016/S0959-440X(00)00137-8  0.306
2000 Larson JL, Ko E, Miranker AD. Direct measurement of islet amyloid polypeptide fibrillogenesis by mass spectrometry. Protein Science : a Publication of the Protein Society. 9: 427-31. PMID 10716196 DOI: 10.1110/Ps.9.2.427  0.427
1999 Weber-Ban EU, Reid BG, Miranker AD, Horwich AL. Global unfolding of a substrate protein by the Hsp100 chaperone ClpA. Nature. 401: 90-3. PMID 10485712 DOI: 10.1038/43481  0.38
1999 Canet D, Sunde M, Last AM, Miranker A, Spencer A, Robinson CV, Dobson CM. Mechanistic studies of the folding of human lysozyme and the origin of amyloidogenic behavior in its disease-related variants. Biochemistry. 38: 6419-27. PMID 10350460 DOI: 10.1021/Bi983037T  0.604
1998 Morgan CJ, Miranker A, Dobson CM. Characterization of collapsed states in the early stages of the refolding of hen lysozyme Biochemistry. 37: 8473-8480. PMID 9622499 DOI: 10.1021/Bi9731504  0.422
1996 Miranker AD, Dobson CM. Collapse and cooperativity in protein folding. Current Opinion in Structural Biology. 6: 31-42. PMID 8696971 DOI: 10.1016/S0959-440X(96)80092-3  0.435
1996 Miranker A, Robinson CV, Radford SE, Dobson CM. Investigation of protein folding by mass spectrometry. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 10: 93-101. PMID 8566553 DOI: 10.1096/Fasebj.10.1.8566553  0.521
1996 Miranker A, Kruppa GH, Robinson CV, Aplin RT, Dobson CM. Isotope-Labeling Strategy for the Assignment of Protein Fragments Generated for Mass Spectrometry Journal of the American Chemical Society. 118: 7402-7403. DOI: 10.1021/Ja9531236  0.515
1995 Hooke SD, Eyles SJ, Miranker A, Radford SE, Robinson CV, Dobson CM. Cooperative Elements in Protein Folding Monitored by Electrospray Ionization Mass Spectrometry Journal of the American Chemical Society. 117: 7548-7549. DOI: 10.1021/Ja00133A030  0.748
1993 Miranker A, Robinson CV, Radford SE, Aplin RT, Dobson CM. Detection of transient protein folding populations by mass spectrometry. Science (New York, N.Y.). 262: 896-900. PMID 8235611 DOI: 10.1126/Science.8235611  0.497
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