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Year Citation  Score
2019 Reinhard NR, Van Der Niet S, Chertkova A, Postma M, Hordijk PL, Gadella TWJ, Goedhart J. Identification of guanine nucleotide exchange factors that increase Cdc42 activity in primary human endothelial cells. Small Gtpases. 1-15. PMID 31469028 DOI: 10.1080/21541248.2019.1658509  1
2018 Long Y, Stahl Y, Weidtkamp-Peters S, Smet W, Du Y, Gadella TWJ, Goedhart J, Scheres B, Blilou I. Optimizing FRET-FLIM Labeling Conditions to Detect Nuclear Protein Interactions at Native Expression Levels in Living Arabidopsis Roots. Frontiers in Plant Science. 9: 639. PMID 29868092 DOI: 10.3389/fpls.2018.00639  1
2018 Mastop M, Reinhard NR, Zuconelli CR, Terwey F, Gadella TWJ, van Unen J, Adjobo-Hermans MJW, Goedhart J. Correction: A FRET-based biosensor for measuring Gα13 activation in single cells. Plos One. 13: e0195649. PMID 29617442 DOI: 10.1371/journal.pone.0195649  1
2018 Mastop M, Reinhard NR, Zuconelli CR, Terwey F, Gadella TWJ, van Unen J, Adjobo-Hermans MJW, Goedhart J. A FRET-based biosensor for measuring Gα13 activation in single cells. Plos One. 13: e0193705. PMID 29505611 DOI: 10.1371/journal.pone.0193705  1
2017 Reinhard NR, Mastop M, Yin T, Wu Y, Bosma EK, Gadella TWJ, Goedhart J, Hordijk PL. The balance between Gαi-Cdc42/Rac and Gα12/13-RhoA pathways determines endothelial barrier regulation by Sphingosine-1-Phosphate. Molecular Biology of the Cell. PMID 28954861 DOI: 10.1091/mbc.E17-03-0136  1
2017 Mastop M, Bindels DS, Shaner NC, Postma M, Gadella TWJ, Goedhart J. Characterization of a spectrally diverse set of fluorescent proteins as FRET acceptors for mTurquoise2. Scientific Reports. 7: 11999. PMID 28931898 DOI: 10.1038/s41598-017-12212-x  1
2017 Long Y, Stahl Y, Weidtkamp-Peters S, Postma M, Zhou W, Goedhart J, Sánchez-Pérez MI, Gadella TWJ, Simon R, Scheres B, Blilou I. In vivo FRET-FLIM reveals cell-type-specific protein interactions in Arabidopsis roots. Nature. PMID 28746306 DOI: 10.1038/nature23317  1
2017 Vermeer JE, Wijk RV, Goedhart J, Geldner N, Chory J, Gadella TW, Munnik T. In Vivo Imaging of Diacylglycerol at the Cytoplasmic Leaflet of Plant Membranes. Plant & Cell Physiology. PMID 28158855 DOI: 10.1093/pcp/pcx012  1
2017 Bindels DS, Haarbosch L, van Weeren L, Postma M, Wiese KE, Mastop M, Aumonier S, Gotthard G, Royant A, Hink MA, Gadella TW. mScarlet: a bright monomeric red fluorescent protein for cellular imaging. Nature Methods. 14: 53-56. PMID 27869816 DOI: 10.1038/nmeth.4074  1
2016 van Unen J, Yin T, Wu YI, Mastop M, Gadella TW, Goedhart J. Kinetics of recruitment and allosteric activation of ARHGEF25 isoforms by the heterotrimeric G-protein Gαq. Scientific Reports. 6: 36825. PMID 27833100 DOI: 10.1038/srep36825  1
2016 van Unen J, Rashidfarrokhi A, Hoogendoorn E, Postma M, Gadella TW, Goedhart J. Quantitative Single-Cell Analysis of Signaling Pathways Activated Immediately Downstream of Histamine Receptor Subtypes. Molecular Pharmacology. 90: 162-76. PMID 27358232 DOI: 10.1124/mol.116.104505  1
2016 Reinhard NR, van Helden SF, Anthony EC, Yin T, Wu YI, Goedhart J, Gadella TW, Hordijk PL. Spatiotemporal analysis of RhoA/B/C activation in primary human endothelial cells. Scientific Reports. 6: 25502. PMID 27147504 DOI: 10.1038/srep25502  1
2016 Raspe M, Kedziora KM, van den Broek B, Zhao Q, de Jong S, Herz J, Mastop M, Goedhart J, Gadella TW, Young IT, Jalink K. siFLIM: single-image frequency-domain FLIM provides fast and photon-efficient lifetime data. Nature Methods. PMID 27088314 DOI: 10.1038/nmeth.3836  1
2016 van Unen J, Stumpf AD, Schmid B, Reinhard NR, Hordijk PL, Hoffmann C, Gadella TW, Goedhart J. A New Generation of FRET Sensors for Robust Measurement of Gαi1, Gαi2 and Gαi3 Activation Kinetics in Single Cells. Plos One. 11: e0146789. PMID 26799488 DOI: 10.1371/journal.pone.0146789  1
2015 van Unen J, Reinhard NR, Yin T, Wu YI, Postma M, Gadella TW, Goedhart J. Plasma membrane restricted RhoGEF activity is sufficient for RhoA-mediated actin polymerization. Scientific Reports. 5: 14693. PMID 26435194 DOI: 10.1038/srep14693  1
2015 Long Y, Goedhart J, Schneijderberg M, Terpestra I, Shimotohno A, Bouchet BP, Akhmanova A, Gadella TW, Heidstra R, Scheres B, Blilou I. SCARECROW-LIKE23 and SCARECROW jointly specify endodermal cell fate but distinctly control SHORT-ROOT movement. The Plant Journal : For Cell and Molecular Biology. PMID 26415082 DOI: 10.1111/tpj.13038  1
2015 Timmerman I, Heemskerk N, Kroon J, Schaefer A, van Rijssel J, Hoogenboezem M, van Unen J, Goedhart J, Gadella TW, Yin T, Wu Y, Huveneers S, van Buul JD. A local VE-cadherin and Trio-based signaling complex stabilizes endothelial junctions through Rac1. Journal of Cell Science. 128: 3514. PMID 26374854 DOI: 10.1242/jcs.179424  1
2015 Timmerman I, Heemskerk N, Kroon J, Schaefer A, van Rijssel J, Hoogenboezem M, van Unen J, Goedhart J, Gadella TW, Yin T, Wu Y, Huveneers S, van Buul JD. A local VE-cadherin/Trio-based signaling complex stabilizes endothelial junctions through Rac1. Journal of Cell Science. PMID 26116572 DOI: 10.1242/jcs.168674  1
2014 Moling S, Pietraszewska-Bogiel A, Postma M, Fedorova E, Hink MA, Limpens E, Gadella TW, Bisseling T. Nod factor receptors form heteromeric complexes and are essential for intracellular infection in medicago nodules. The Plant Cell. 26: 4188-99. PMID 25351493 DOI: 10.1105/tpc.114.129502  1
2014 Hoogendoorn E, Crosby KC, Leyton-Puig D, Breedijk RM, Jalink K, Gadella TW, Postma M. The fidelity of stochastic single-molecule super-resolution reconstructions critically depends upon robust background estimation. Scientific Reports. 4: 3854. PMID 24458236 DOI: 10.1038/srep03854  1
2014 Bindels DS, Goedhart J, Hink MA, van Weeren L, Joosen L, Gadella TW. Optimization of fluorescent proteins. Methods in Molecular Biology (Clifton, N.J.). 1076: 371-417. PMID 24108635 DOI: 10.1007/978-1-62703-649-8_16  1
2013 Goedhart J, van Unen J, Adjobo-Hermans MJ, Gadella TW. Signaling efficiency of Gαq through its effectors p63RhoGEF and GEFT depends on their subcellular location. Scientific Reports. 3: 2284. PMID 23884432 DOI: 10.1038/srep02284  1
2013 Pietraszewska-Bogiel A, Lefebvre B, Koini MA, Klaus-Heisen D, Takken FL, Geurts R, Cullimore JV, Gadella TW. Interaction of Medicago truncatula lysin motif receptor-like kinases, NFP and LYK3, produced in Nicotiana benthamiana induces defence-like responses. Plos One. 8: e65055. PMID 23750228 DOI: 10.1371/journal.pone.0065055  1
2013 Crosby KC, Postma M, Hink MA, Zeelenberg CH, Adjobo-Hermans MJ, Gadella TW. Quantitative analysis of self-association and mobility of annexin A4 at the plasma membrane. Biophysical Journal. 104: 1875-85. PMID 23663830 DOI: 10.1016/j.bpj.2013.02.057  1
2013 Bilan DS, Pase L, Joosen L, Gorokhovatsky AY, Ermakova YG, Gadella TW, Grabher C, Schultz C, Lukyanov S, Belousov VV. HyPer-3: a genetically encoded H(2)O(2) probe with improved performance for ratiometric and fluorescence lifetime imaging. Acs Chemical Biology. 8: 535-42. PMID 23256573 DOI: 10.1021/cb300625g  0.32
2013 Adjobo-Hermans MJ, Crosby KC, Putyrski M, Bhageloe A, van Weeren L, Schultz C, Goedhart J, Gadella TW. PLCβ isoforms differ in their subcellular location and their CT-domain dependent interaction with Gαq. Cellular Signalling. 25: 255-63. PMID 23006664 DOI: 10.1016/j.cellsig.2012.09.022  1
2012 von Stetten D, Noirclerc-Savoye M, Goedhart J, Gadella TW, Royant A. Structure of a fluorescent protein from Aequorea victoria bearing the obligate-monomer mutation A206K. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 68: 878-82. PMID 22869113 DOI: 10.1107/S1744309112028667  1
2012 Shcherbakova DM, Hink MA, Joosen L, Gadella TW, Verkhusha VV. An orange fluorescent protein with a large Stokes shift for single-excitation multicolor FCCS and FRET imaging. Journal of the American Chemical Society. 134: 7913-23. PMID 22486524 DOI: 10.1021/ja3018972  1
2012 Goedhart J, von Stetten D, Noirclerc-Savoye M, Lelimousin M, Joosen L, Hink MA, van Weeren L, Gadella TW, Royant A. Structure-guided evolution of cyan fluorescent proteins towards a quantum yield of 93%. Nature Communications. 3: 751. PMID 22434194 DOI: 10.1038/ncomms1738  1
2012 Lefebvre B, Klaus-Heisen D, Pietraszewska-Bogiel A, Hervé C, Camut S, Auriac MC, Gasciolli V, Nurisso A, Gadella TW, Cullimore J. Role of N-glycosylation sites and CXC motifs in trafficking of medicago truncatula Nod factor perception protein to plasma membrane. The Journal of Biological Chemistry. 287: 10812-23. PMID 22334694 DOI: 10.1074/jbc.M111.281634  1
2011 Goedhart J, van Weeren L, Adjobo-Hermans MJ, Elzenaar I, Hink MA, Gadella TW. Quantitative co-expression of proteins at the single cell level--application to a multimeric FRET sensor. Plos One. 6: e27321. PMID 22114669 DOI: 10.1371/journal.pone.0027321  1
2011 Crosby KC, Pietraszewska-Bogiel A, Gadella TW, Winkel BS. Förster resonance energy transfer demonstrates a flavonoid metabolon in living plant cells that displays competitive interactions between enzymes. Febs Letters. 585: 2193-8. PMID 21669202 DOI: 10.1016/j.febslet.2011.05.066  1
2011 Adjobo-Hermans MJ, Goedhart J, van Weeren L, Nijmeijer S, Manders EM, Offermanns S, Gadella TW. Real-time visualization of heterotrimeric G protein Gq activation in living cells. Bmc Biology. 9: 32. PMID 21619590 DOI: 10.1186/1741-7007-9-32  1
2011 Klarenbeek JB, Goedhart J, Hink MA, Gadella TW, Jalink K. A mTurquoise-based cAMP sensor for both FLIM and ratiometric read-out has improved dynamic range. Plos One. 6: e19170. PMID 21559477 DOI: 10.1371/journal.pone.0019170  1
2011 Klaus-Heisen D, Nurisso A, Pietraszewska-Bogiel A, Mbengue M, Camut S, Timmers T, Pichereaux C, Rossignol M, Gadella TW, Imberty A, Lefebvre B, Cullimore JV. Structure-function similarities between a plant receptor-like kinase and the human interleukin-1 receptor-associated kinase-4. The Journal of Biological Chemistry. 286: 11202-10. PMID 21205819 DOI: 10.1074/jbc.M110.186171  1
2010 Subach FV, Zhang L, Gadella TW, Gurskaya NG, Lukyanov KA, Verkhusha VV. Red fluorescent protein with reversibly photoswitchable absorbance for photochromic FRET. Chemistry & Biology. 17: 745-55. PMID 20659687 DOI: 10.1016/j.chembiol.2010.05.022  0.12
2010 Schultz C, Neef AB, Gadella TW, Goedhart J. Imaging lipids in living cells. Cold Spring Harbor Protocols. 2010: pdb.top83. PMID 20647368  1
2010 Schultz C, Neef AB, Gadella TW, Goedhart J. Labeling lipids for imaging in live cells. Cold Spring Harbor Protocols. 2010: pdb.prot5459. PMID 20647363  1
2010 Schultz C, Neef AB, Gadella TW, Goedhart J. Labeling lipids for imaging in fixed cells. Cold Spring Harbor Protocols. 2010: pdb.prot5458. PMID 20647362  1
2010 Schultz C, Neef AB, Gadella TW, Goedhart J. Transfection of cells with DNA encoding a visible fluorescent protein-tagged lipid-binding domain. Cold Spring Harbor Protocols. 2010: pdb.prot5457. PMID 20647361  1
2010 Alexeeva S, Gadella TW, Verheul J, Verhoeven GS, den Blaauwen T. Direct interactions of early and late assembling division proteins in Escherichia coli cells resolved by FRET. Molecular Microbiology. 77: 384-98. PMID 20497333 DOI: 10.1111/j.1365-2958.2010.07211.x  0.01
2010 Goedhart J, van Weeren L, Hink MA, Vischer NO, Jalink K, Gadella TW. Bright cyan fluorescent protein variants identified by fluorescence lifetime screening. Nature Methods. 7: 137-9. PMID 20081836 DOI: 10.1038/nmeth.1415  1
2009 Shcherbo D, Souslova EA, Goedhart J, Chepurnykh TV, Gaintzeva A, Shemiakina II, Gadella TW, Lukyanov S, Chudakov DM. Practical and reliable FRET/FLIM pair of fluorescent proteins. Bmc Biotechnology. 9: 24. PMID 19321010 DOI: 10.1186/1472-6750-9-24  1
2009 Vermeer JE, Thole JM, Goedhart J, Nielsen E, Munnik T, Gadella TW. Imaging phosphatidylinositol 4-phosphate dynamics in living plant cells. The Plant Journal : For Cell and Molecular Biology. 57: 356-72. PMID 18785997 DOI: 10.1111/j.1365-313X.2008.03679.x  1
2008 Adjobo-Hermans MJ, Goedhart J, Gadella TW. Regulation of PLCbeta1a membrane anchoring by its substrate phosphatidylinositol (4,5)-bisphosphate. Journal of Cell Science. 121: 3770-7. PMID 18957514 DOI: 10.1242/jcs.029785  1
2008 Schenning M, Goedhart J, Gadella TW, Avram D, Wirtz KW, Snoek GT. The anti-apoptotic activity associated with phosphatidylinositol transfer protein alpha activates the MAPK and Akt/PKB pathway. Biochimica Et Biophysica Acta. 1783: 1700-6. PMID 18501717 DOI: 10.1016/j.bbamcr.2008.04.014  1
2008 Kremers GJ, van Munster EB, Goedhart J, Gadella TW. Quantitative lifetime unmixing of multiexponentially decaying fluorophores using single-frequency fluorescence lifetime imaging microscopy. Biophysical Journal. 95: 378-89. PMID 18359789 DOI: 10.1529/biophysj.107.125229  1
2008 Dhonukshe P, Grigoriev I, Fischer R, Tominaga M, Robinson DG, Hasek J, Paciorek T, Petrásek J, Seifertová D, Tejos R, Meisel LA, Zazímalová E, Gadella TW, Stierhof YD, Ueda T, et al. Auxin transport inhibitors impair vesicle motility and actin cytoskeleton dynamics in diverse eukaryotes. Proceedings of the National Academy of Sciences of the United States of America. 105: 4489-94. PMID 18337510 DOI: 10.1073/pnas.0711414105  0.08
2008 Rino J, Desterro JM, Pacheco TR, Gadella TW, Carmo-Fonseca M. Splicing factors SF1 and U2AF associate in extraspliceosomal complexes. Molecular and Cellular Biology. 28: 3045-57. PMID 18285458 DOI: 10.1128/MCB.02015-07  0.01
2008 Thole JM, Vermeer JE, Zhang Y, Gadella TW, Nielsen E. Root hair defective4 encodes a phosphatidylinositol-4-phosphate phosphatase required for proper root hair development in Arabidopsis thaliana. The Plant Cell. 20: 381-95. PMID 18281508 DOI: 10.1105/tpc.107.054304  0.01
2007 Goedhart J, Vermeer JE, Adjobo-Hermans MJ, van Weeren L, Gadella TW. Sensitive detection of p65 homodimers using red-shifted and fluorescent protein-based FRET couples. Plos One. 2: e1011. PMID 17925859 DOI: 10.1371/journal.pone.0001011  1
2007 van Leeuwen W, Vermeer JE, Gadella TW, Munnik T. Visualization of phosphatidylinositol 4,5-bisphosphate in the plasma membrane of suspension-cultured tobacco BY-2 cells and whole Arabidopsis seedlings. The Plant Journal : For Cell and Molecular Biology. 52: 1014-26. PMID 17908156 DOI: 10.1111/j.1365-313X.2007.03292.x  1
2007 Merzlyak EM, Goedhart J, Shcherbo D, Bulina ME, Shcheglov AS, Fradkov AF, Gaintzeva A, Lukyanov KA, Lukyanov S, Gadella TW, Chudakov DM. Bright monomeric red fluorescent protein with an extended fluorescence lifetime. Nature Methods. 4: 555-7. PMID 17572680 DOI: 10.1038/nmeth1062  1
2007 Kremers GJ, Goedhart J, van den Heuvel DJ, Gerritsen HC, Gadella TW. Improved green and blue fluorescent proteins for expression in bacteria and mammalian cells. Biochemistry. 46: 3775-83. PMID 17323929 DOI: 10.1021/bi0622874  1
2006 Adjobo-Hermans MJ, Goedhart J, Gadella TW. Plant G protein heterotrimers require dual lipidation motifs of Galpha and Ggamma and do not dissociate upon activation. Journal of Cell Science. 119: 5087-97. PMID 17158913 DOI: 10.1242/jcs.03284  1
2006 Vermeer JE, van Leeuwen W, Tobeña-Santamaria R, Laxalt AM, Jones DR, Divecha N, Gadella TW, Munnik T. Visualization of PtdIns3P dynamics in living plant cells. The Plant Journal : For Cell and Molecular Biology. 47: 687-700. PMID 16856980 DOI: 10.1111/j.1365-313X.2006.02830.x  1
2006 Kremers GJ, Goedhart J, van Munster EB, Gadella TW. Cyan and yellow super fluorescent proteins with improved brightness, protein folding, and FRET Förster radius. Biochemistry. 45: 6570-80. PMID 16716067 DOI: 10.1021/bi0516273  1
2006 Dhonukshe P, Baluska F, Schlicht M, Hlavacka A, Samaj J, Friml J, Gadella TW. Endocytosis of cell surface material mediates cell plate formation during plant cytokinesis. Developmental Cell. 10: 137-50. PMID 16399085 DOI: 10.1016/j.devcel.2005.11.015  1
2005 van Munster EB, Gadella TW. Fluorescence lifetime imaging microscopy (FLIM). Advances in Biochemical Engineering/Biotechnology. 95: 143-75. PMID 16080268  1
2005 Schultz C, Schleifenbaum A, Goedhart J, Gadella TW. Multiparameter imaging for the analysis of intracellular signaling. Chembiochem : a European Journal of Chemical Biology. 6: 1323-30. PMID 16010697 DOI: 10.1002/cbic.200500012  1
2005 Goedhart J, Gadella TW. Analysis of oligonucleotide annealing by electrophoresis in agarose gels using sodium borate conductive medium. Analytical Biochemistry. 343: 186-7. PMID 15950908 DOI: 10.1016/j.ab.2005.04.048  1
2004 Lansbergen G, Komarova Y, Modesti M, Wyman C, Hoogenraad CC, Goodson HV, Lemaitre RP, Drechsel DN, van Munster E, Gadella TW, Grosveld F, Galjart N, Borisy GG, Akhmanova A. Conformational changes in CLIP-170 regulate its binding to microtubules and dynactin localization. The Journal of Cell Biology. 166: 1003-14. PMID 15381688 DOI: 10.1083/jcb.200402082  1
2004 Goedhart J, Gadella TW. Photolysis of caged phosphatidic acid induces flagellar excision in Chlamydomonas. Biochemistry. 43: 4263-71. PMID 15065870 DOI: 10.1021/bi0351460  1
2004 van Munster EB, Gadella TW. Suppression of photobleaching-induced artifacts in frequency-domain FLIM by permutation of the recording order. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. 58: 185-94. PMID 15057972 DOI: 10.1002/cyto.a.20013  1
2003 Postma M, Roelofs J, Goedhart J, Gadella TW, Visser AJ, Van Haastert PJ. Uniform cAMP stimulation of Dictyostelium cells induces localized patches of signal transduction and pseudopodia. Molecular Biology of the Cell. 14: 5019-27. PMID 14595105 DOI: 10.1091/mbc.E03-08-0566  1
2003 Goedhart J, Bono JJ, Bisseling T, Gadella TW. Identical accumulation and immobilization of sulfated and nonsulfated Nod factors in host and nonhost root hair cell walls. Molecular Plant-Microbe Interactions : Mpmi. 16: 884-92. PMID 14558690 DOI: 10.1094/MPMI.2003.16.10.884  1
2003 Dhonukshe P, Laxalt AM, Goedhart J, Gadella TW, Munnik T. Phospholipase d activation correlates with microtubule reorganization in living plant cells. The Plant Cell. 15: 2666-79. PMID 14508002 DOI: 10.1105/tpc.014977  1
2003 de la Fuente van Bentem S, Vossen JH, Vermeer JE, de Vroomen MJ, Gadella TW, Haring MA, Cornelissen BJ. The subcellular localization of plant protein phosphatase 5 isoforms is determined by alternative splicing. Plant Physiology. 133: 702-12. PMID 12972652 DOI: 10.1104/pp.103.026617  1
2002 Goedhart J, Bono JJ, Gadella TWJ. Rapid colorimetric quantification of lipo-chitooligosaccharides from Mesorhizobium loti and Sinorhizobium meliloti Molecular Plant-Microbe Interactions. 15: 859-865. PMID 12236592  1
2002 Shah K, Russinova E, Gadella TW, Willemse J, De Vries SC. The Arabidopsis kinase-associated protein phosphatase controls internalization of the somatic embryogenesis receptor kinase 1. Genes & Development. 16: 1707-20. PMID 12101128 DOI: 10.1101/gad.220402  1
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