| Year |
Citation |
Score |
| 2024 |
Ceccarelli G, Goracci L, Carotti A, Paccoia F, Passeri D, Cipolloni M, Di Bona S, Cruciani G, Pellicciari R, Gioiello A. Discovery and Structure-Activity Relationships of Novel DAF-12 Receptor Modulators. Journal of Medicinal Chemistry. PMID 38417155 DOI: 10.1021/acs.jmedchem.3c02421 |
0.726 |
|
| 2023 |
Rosatelli E, Carotti A, Cerra B, De Franco F, Passeri D, Pellicciari R, Gioiello A. Chemical exploration of TGR5 functional hot-spots: Synthesis and structure-activity relationships of C7- and C23-Substituted cholic acid derivatives. European Journal of Medicinal Chemistry. 261: 115851. PMID 37813065 DOI: 10.1016/j.ejmech.2023.115851 |
0.762 |
|
| 2023 |
Bianconi E, Riccio A, Ruta L, Bigiotti C, Carotti A, Moretti S, Cerra B, Gioiello A, Ferlin S, Puxeddu E, Macchiarulo A. Turning a Tumor Microenvironment Pitfall into Opportunity: Discovery of Benzamidoxime as PD-L1 Ligand with pH-Dependent Potency. International Journal of Molecular Sciences. 24. PMID 36982608 DOI: 10.3390/ijms24065535 |
0.488 |
|
| 2022 |
Cerra B, Venturoni F, Souma M, Ceccarelli G, Lozza AM, Passeri D, De Franco F, Baxendale IR, Pellicciari R, Macchiarulo A, Gioiello A. Development of 3α,7α-dihydroxy-6α-ethyl-24-nor-5β-cholan-23-sulfate sodium salt (INT-767): Process optimization, synthesis and characterization of metabolites. European Journal of Medicinal Chemistry. 242: 114652. PMID 36049273 DOI: 10.1016/j.ejmech.2022.114652 |
0.775 |
|
| 2021 |
Mancino V, Ceccarelli G, Carotti A, Goracci L, Sardella R, Passeri D, Pellicciari R, Gioiello A. Synthesis and biological activity of cyclopropyl Δ7-dafachronic acids as DAF-12 receptor ligands. Organic & Biomolecular Chemistry. PMID 34056641 DOI: 10.1039/d1ob00912e |
0.744 |
|
| 2021 |
Perino A, Velázquez-Villegas LA, Bresciani N, Sun Y, Huang Q, Fénelon VS, Castellanos-Jankiewicz A, Zizzari P, Bruschetta G, Jin S, Baleisyte A, Gioiello A, Pellicciari R, Ivanisevic J, Schneider BL, et al. Central anorexigenic actions of bile acids are mediated by TGR5. Nature Metabolism. 3: 595-603. PMID 34031591 DOI: 10.1038/s42255-021-00398-4 |
0.686 |
|
| 2020 |
Riccio A, Coletti A, Dolciami D, Mammoli A, Cerra B, Moretti S, Gioiello A, Ferlin S, Puxeddu E, Macchiarulo A. The Stone Guest: How Does pH Affect Binding Properties of PD-1/PD-L1 Inhibitors ? Chemmedchem. PMID 33085193 DOI: 10.1002/cmdc.202000760 |
0.488 |
|
| 2020 |
Dvorak Z, Klapholz M, Burris TP, Willing BP, Gioiello A, Pellicciari R, Galli F, March J, Sartor RB, Kim C, Levy M, Mani S, O'Keefe SJ. . Molecular Pharmacology. PMID 32764096 DOI: 10.1124/Molpharm.120.000035 |
0.71 |
|
| 2020 |
Ianni F, Cerra B, Shandiz ST, Michele AD, Saluti G, Galarini R, Gioiello A, Sardella R, Carotti A. Integrating experimental and computational techniques to study chromatographic enantioresolutions of chiral tetrahydroindazole derivatives. Journal of Chromatography. A. 1625: 461310. PMID 32709352 DOI: 10.1016/J.Chroma.2020.461310 |
0.332 |
|
| 2020 |
Marinelli R, Torquato P, Bartolini D, Mas-Bargues C, Bellezza G, Gioiello A, Borras C, De Luca A, Fallarino F, Sebastiani B, Mani S, Sidoni A, Vina J, Leri M, Bucciantini M, et al. Garcinoic acid prevents β-amyloid (Aβ) deposition in the mouse brain. The Journal of Biological Chemistry. PMID 32616652 DOI: 10.1074/Jbc.Ra120.013303 |
0.302 |
|
| 2020 |
Sorrentino G, Perino A, Yildiz E, El Alam G, Sleiman MB, Gioiello A, Pellicciari R, Schoonjans K. Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration. Gastroenterology. PMID 32485177 DOI: 10.1053/J.Gastro.2020.05.067 |
0.706 |
|
| 2020 |
Bartolini D, De Franco F, Torquato P, Marinelli R, Cerra B, Ronchetti R, Schön A, Fallarino F, De Luca A, Bellezza G, Ferri I, Sidoni A, Walton WG, Pellock SJ, Redinbo MR, ... ... Gioiello A, et al. Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. Journal of Medicinal Chemistry. PMID 32160459 DOI: 10.1021/Acs.Jmedchem.0C00012.S001 |
0.759 |
|
| 2020 |
Gioiello A, Piccinno A, Lozza AM, Cerra B. The Medicinal Chemistry in the Era of Machines and Automation: Recent Advances in Continuous Flow Technology. Journal of Medicinal Chemistry. PMID 32049517 DOI: 10.1021/Acs.Jmedchem.9B01956 |
0.341 |
|
| 2020 |
Cerra B, Macchiarulo A, Carotti A, Camaioni E, Varfaj I, Sardella R, Gioiello A. Enantioselective HPLC Analysis to Assist the Chemical Exploration of Chiral Imidazolines. Molecules (Basel, Switzerland). 25. PMID 32024219 DOI: 10.3390/Molecules25030640 |
0.582 |
|
| 2020 |
Sardella R, Camaioni E, Macchiarulo A, Gioiello A, Marinozzi M, Carotti A. Computational studies in enantioselective liquid chromatography: Forty years of evolution in docking- and molecular dynamics-based simulations Trac Trends in Analytical Chemistry. 122: 115703. DOI: 10.1016/J.Trac.2019.115703 |
0.55 |
|
| 2019 |
Passeri D, Carotti A, Pittol JMR, Ciaccioli G, Pellicciari R, van Mil SWC, Gioiello A. Dissecting the allosteric FXR modulation: a chemical biology approach using guggulsterone as a chemical tool. Medchemcomm. 10: 1412-1419. PMID 31673308 DOI: 10.1039/C9Md00264B |
0.736 |
|
| 2019 |
Giusepponi D, Galarini R, Barola C, Torquato P, Bartolini D, Moretti S, Saluti G, Gioiello A, Libetta C, Galli F. LC-MS/MS assay for the simultaneous determination of tocopherols, polyunsaturated fatty acids and their metabolites in human plasma and serum. Free Radical Biology & Medicine. PMID 31009660 DOI: 10.1016/J.Freeradbiomed.2019.04.017 |
0.342 |
|
| 2019 |
Cerra B, Carotti A, Passeri D, Sardella R, Moroni G, Di Michele A, Macchiarulo A, Pellicciari R, Gioiello A. Exploiting Chemical Toolboxes for the Expedited Generation of Tetracyclic Quinolines as a Novel Class of PXR Agonists. Acs Medicinal Chemistry Letters. 10: 677-681. PMID 30996817 DOI: 10.1021/Acsmedchemlett.8B00459 |
0.773 |
|
| 2019 |
Schoubben A, Vivani R, Paolantoni M, Perinelli DR, Gioiello A, Macchiarulo A, Ricci M. D-leucine microparticles as an excipient to improve the aerosolization performances of dry powders for inhalation. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. PMID 30677523 DOI: 10.1016/J.Ejps.2019.01.018 |
0.536 |
|
| 2019 |
Franco P, Porru E, Fiori J, Gioiello A, Cerra B, Roda G, Caliceti C, Simoni P, Roda A. Identification and quantification of oxo-bile acids in human faeces with liquid chromatography-mass spectrometry: A potent tool for human gut acidic sterolbiome studies. Journal of Chromatography A. 1585: 70-81. PMID 30482431 DOI: 10.1016/J.Chroma.2018.11.038 |
0.371 |
|
| 2018 |
Nocentini A, Bonardi A, Gratteri P, Cerra B, Gioiello A, Supuran CT. Steroids interfere with human carbonic anhydrase activity by using alternative binding mechanisms. Journal of Enzyme Inhibition and Medicinal Chemistry. 33: 1453-1459. PMID 30221552 DOI: 10.1080/14756366.2018.1512597 |
0.316 |
|
| 2018 |
Moretti S, Lega F, Rigoni L, Saluti G, Giusepponi D, Gioiello A, Manuali E, Rossi R, Galarini R. Multiclass screening method to detect more than fifty banned substances in bovine bile and urine. Analytica Chimica Acta. 1032: 56-67. PMID 30143222 DOI: 10.1016/J.Aca.2018.06.037 |
0.314 |
|
| 2018 |
Massafra V, Pellicciari R, Gioiello A, van Mil SWC. Progress and challenges of selective Farnesoid X receptor modulation. Pharmacology & Therapeutics. PMID 29933033 DOI: 10.1016/J.Pharmthera.2018.06.009 |
0.764 |
|
| 2018 |
Ianni F, Pucciarini L, Carotti A, Gioiello A, Galarini R, Natalini S, Sardella R, Lindner W, Natalini B. Improved chromatographic diastereoresolution of cyclopropyl dafachronic acid derivatives using chiral anion exchangers. Journal of Chromatography. A. PMID 29724644 DOI: 10.1016/J.Chroma.2018.04.062 |
0.346 |
|
| 2018 |
Venturoni F, Cerra B, Marinozzi M, Camaioni E, Gioiello A, Pellicciari R. BF3·Et2O-Promoted Decomposition of Cyclic α-Diazo-β-Hydroxy Ketones: Novel Insights into Mechanistic Aspects Catalysts. 8: 600. DOI: 10.3390/Catal8120600 |
0.707 |
|
| 2017 |
Mostarda S, Passeri D, Carotti A, Cerra B, Colliva C, Benicchi T, Macchiarulo A, Pellicciari R, Gioiello A. Synthesis, physicochemical properties, and biological activity of bile acids 3-glucuronides: Novel insights into bile acid signalling and detoxification. European Journal of Medicinal Chemistry. 144: 349-358. PMID 29275233 DOI: 10.1016/J.Ejmech.2017.12.034 |
0.814 |
|
| 2017 |
Gatticchi L, Cerra B, Scarpelli P, Macchioni L, Sebastiani B, Gioiello A, Roberti R. Selected cholesterol biosynthesis inhibitors produce accumulation of the intermediate FF-MAS that targets nucleus and activates LXRα in HepG2 cells. Biochimica Et Biophysica Acta. PMID 28499814 DOI: 10.1016/J.Bbalip.2017.05.004 |
0.346 |
|
| 2017 |
Cerra B, Mangiavacchi F, Santi C, Lozza AM, Gioiello A. Selective continuous flow synthesis of hydroxy lactones from alkenoic acids Reaction Chemistry & Engineering. 2: 467-471. DOI: 10.1039/C7Re00083A |
0.401 |
|
| 2017 |
Sancineto L, Mangiavacchi F, Tidei C, Bagnoli L, Marini F, Gioiello A, Scianowski J, Santi C. Selenium-Catalyzed Oxacyclization of Alkenoic Acids and Alkenols Asian Journal of Organic Chemistry. 6: 988-992. DOI: 10.1002/Ajoc.201700193 |
0.365 |
|
| 2016 |
Pellicciari R, Passeri D, De Franco F, Mostarda S, Filipponi P, Colliva C, Gadaleta R, Franco P, Carotti A, Macchiarulo A, Roda A, Moschetta A, Gioiello A. Discovery of 3α,7α,11β-Trihydroxy-6α-ethyl-5β-cholan-24-oic Acid (TC-100), a Novel Bile Acid as Potent and Highly Selective FXR Agonist for Enterohepatic Disorders. Journal of Medicinal Chemistry. PMID 27652492 DOI: 10.1021/Acs.Jmedchem.6B01126 |
0.801 |
|
| 2016 |
Margheritis E, Castellani B, Magotti P, Peruzzi S, Romeo E, Natali F, Mostarda S, Gioiello A, Piomelli D, Garau G. Bile Acid Recognition by NAPE-PLD. Acs Chemical Biology. PMID 27571266 DOI: 10.1021/Acschembio.6B00624 |
0.44 |
|
| 2016 |
Greco FA, Coletti A, Camaioni E, Carotti A, Marinozzi M, Gioiello A, Macchiarulo A. The Janus-faced nature of IDO1 in infectious diseases: challenges and therapeutic opportunities. Future Medicinal Chemistry. 8: 39-54. PMID 26692277 DOI: 10.4155/Fmc.15.165 |
0.544 |
|
| 2016 |
Cerra B, Mostarda S, Custodi C, Macchiarulo A, Gioiello A. Integrating multicomponent flow synthesis and computational approaches for the generation of a tetrahydroquinoline compound based library Medchemcomm. 7: 439-446. DOI: 10.1039/C5Md00455A |
0.566 |
|
| 2015 |
Giorgio C, Russo S, Incerti M, Bugatti A, Vacondio F, Barocelli E, Mor M, Pala D, Hassan-Mohamed I, Gioiello A, Rusnati M, Lodola A, Tognolini M. Biochemical characterization of EphA2 antagonists with improved physico-chemical properties by cell-based assays and surface plasmon resonance analysis. Biochemical Pharmacology. PMID 26462575 DOI: 10.1016/J.Bcp.2015.10.006 |
0.385 |
|
| 2015 |
Passeri D, Camaioni E, Liscio P, Sabbatini P, Ferri M, Carotti A, Giacchè N, Pellicciari R, Gioiello A, Macchiarulo A. Concepts and Molecular Aspects in the Polypharmacology of PARP-1 Inhibitors. Chemmedchem. PMID 26424664 DOI: 10.1002/Cmdc.201500391 |
0.742 |
|
| 2015 |
Bijsmans IT, Guercini C, Ramos Pittol JM, Omta W, Milona A, Lelieveld D, Egan DA, Pellicciari R, Gioiello A, van Mil SW. The glucocorticoid mometasone furoate is a novel FXR ligand that decreases inflammatory but not metabolic gene expression. Scientific Reports. 5: 14086. PMID 26369990 DOI: 10.1038/Srep14086 |
0.713 |
|
| 2015 |
Zhang W, Jha P, Wolfe B, Gioiello A, Pellicciari R, Wang J, Heubi J, Setchell KD. Tandem Mass Spectrometric Determination of Atypical 3β-Hydroxy-Δ5-Bile Acids in Patients with 3β-Hydroxy-Δ5-C27-Steroid Oxidoreductase Deficiency: Application to Diagnosis and Monitoring of Bile Acid Therapeutic Response. Clinical Chemistry. 61: 955-63. PMID 25931455 DOI: 10.1373/Clinchem.2015.238238 |
0.735 |
|
| 2014 |
Ianni F, Sardella R, Lisanti A, Gioiello A, Cenci Goga BT, Lindner W, Natalini B. Achiral-chiral two-dimensional chromatography of free amino acids in milk: A promising tool for detecting different levels of mastitis in cows Journal of Pharmaceutical and Biomedical Analysis. 116: 40-46. PMID 25617178 DOI: 10.1016/J.Jpba.2014.12.041 |
0.312 |
|
| 2014 |
Carotti A, Marinozzi M, Custodi C, Cerra B, Pellicciari R, Gioiello A, Macchiarulo A. Beyond bile acids: targeting Farnesoid X Receptor (FXR) with natural and synthetic ligands. Current Topics in Medicinal Chemistry. 14: 2129-42. PMID 25388537 DOI: 10.2174/1568026614666141112094058 |
0.793 |
|
| 2014 |
Gioiello A, Cerra B, Mostarda S, Guercini C, Pellicciari R, Macchiarulo A. Bile acid derivatives as ligands of the farnesoid x receptor: molecular determinants for bile acid binding and receptor modulation. Current Topics in Medicinal Chemistry. 14: 2159-74. PMID 25388535 DOI: 10.2174/1568026614666141112100208 |
0.815 |
|
| 2014 |
Mostarda S, Filipponi P, Sardella R, Venturoni F, Natalini B, Pellicciari R, Gioiello A. Glucuronidation of bile acids under flow conditions: design of experiments and Koenigs-Knorr reaction optimization. Organic & Biomolecular Chemistry. 12: 9592-600. PMID 25338931 DOI: 10.1039/C4Ob01911C |
0.723 |
|
| 2014 |
Marchand JR, Carotti A, Passeri D, Filipponi P, Liscio P, Camaioni E, Pellicciari R, Gioiello A, Macchiarulo A. Investigating the allosteric reverse signalling of PARP inhibitors with microsecond molecular dynamic simulations and fluorescence anisotropy. Biochimica Et Biophysica Acta. 1844: 1765-72. PMID 25062913 DOI: 10.1016/J.Bbapap.2014.07.012 |
0.739 |
|
| 2014 |
Gioiello A, Cerra B, Zhang W, Vallerini GP, Costantino G, De Franco F, Passeri D, Pellicciari R, Setchell KD. Synthesis of atypical bile acids for use as investigative tools for the genetic defect of 3β-hydroxy-Δ(5)-C27-steroid oxidoreductase deficiency. The Journal of Steroid Biochemistry and Molecular Biology. 144: 348-60. PMID 24954360 DOI: 10.1016/J.Jsbmb.2014.06.008 |
0.754 |
|
| 2014 |
Roda A, Pellicciari R, Gioiello A, Neri F, Camborata C, Passeri D, De Franco F, Spinozzi S, Colliva C, Adorini L, Montagnani M, Aldini R. Semisynthetic bile acid FXR and TGR5 agonists: physicochemical properties, pharmacokinetics, and metabolism in the rat. The Journal of Pharmacology and Experimental Therapeutics. 350: 56-68. PMID 24784847 DOI: 10.1124/Jpet.114.214650 |
0.727 |
|
| 2014 |
Sardella R, Carotti A, Gioiello A, Lisanti A, Ianni F, Lindner W, Natalini B. Chromatographic separation of free dafachronic acid epimers with a novel triazole click quinidine-based chiral stationary phase Journal of Chromatography A. 1339: 96-102. PMID 24647100 DOI: 10.1016/J.Chroma.2014.02.080 |
0.355 |
|
| 2014 |
Natalini B, Sardella R, Gioiello A, Ianni F, Di Michele A, Marinozzi M. Determination of bile salt critical micellization concentration on the road to drug discovery Journal of Pharmaceutical and Biomedical Analysis. 87: 62-81. PMID 23870107 DOI: 10.1016/J.Jpba.2013.06.029 |
0.396 |
|
| 2014 |
Gioiello A, Venturoni F, Tamimi S, Custodi C, Pellicciari R, MacChiarulo A. Conformational properties of cholic acid, a lead compound at the crossroads of bile acid inspired drug discovery Medchemcomm. 5: 750-757. DOI: 10.1039/C4Md00024B |
0.794 |
|
| 2014 |
Filipponi P, Ostacolo C, Novellino E, Pellicciari R, Gioiello A. Continuous flow synthesis of thieno[2,3-c ]isoquinolin-5(4 H)-one scaffold: A valuable source of PARP-1 inhibitors Organic Process Research and Development. 18: 1345-1353. DOI: 10.1021/Op500074H |
0.698 |
|
| 2013 |
Macchiarulo A, Gioiello A, Thomas C, Pols TW, Nuti R, Ferrari C, Giacchè N, De Franco F, Pruzanski M, Auwerx J, Schoonjans K, Pellicciari R. Probing the Binding Site of Bile Acids in TGR5. Acs Medicinal Chemistry Letters. 4: 1158-62. PMID 24900622 DOI: 10.1021/Ml400247K |
0.789 |
|
| 2013 |
Russo S, Incerti M, Tognolini M, Castelli R, Pala D, Hassan-Mohamed I, Giorgio C, De Franco F, Gioiello A, Vicini P, Barocelli E, Rivara S, Mor M, Lodola A. Synthesis and structure-activity relationships of amino acid conjugates of cholanic acid as antagonists of the EphA2 receptor. Molecules (Basel, Switzerland). 18: 13043-60. PMID 24152675 DOI: 10.3390/Molecules181013043 |
0.48 |
|
| 2013 |
Sabbatini P, Filipponi P, Sardella R, Natalini B, Nuti R, Macchiarulo A, Pellicciari R, Gioiello A. Synthesis and quantitative structure-property relationships of side chain-modified hyodeoxycholic acid derivatives. Molecules (Basel, Switzerland). 18: 10497-513. PMID 23999724 DOI: 10.3390/Molecules180910497 |
0.82 |
|
| 2013 |
Gioiello A, Rosatelli E, Teofrasti M, Filipponi P, Pellicciari R. Building a sulfonamide library by eco-friendly flow synthesis. Acs Combinatorial Science. 15: 235-9. PMID 23514257 DOI: 10.1021/Co400012M |
0.692 |
|
| 2013 |
Macchiarulo A, Carotti A, Cellanetti M, Sardella R, Gioiello A. Navigations of chemical space to further the understanding of polypharmacology in human nuclear receptors Medchemcomm. 4: 216-227. DOI: 10.1039/C2Md20157G |
0.586 |
|
| 2012 |
Pellicciari R, Gioiello A, Sabbatini P, Venturoni F, Nuti R, Colliva C, Rizzo G, Adorini L, Pruzanski M, Roda A, Macchiarulo A. Avicholic Acid: A Lead Compound from Birds on the Route to Potent TGR5 Modulators. Acs Medicinal Chemistry Letters. 3: 273-7. PMID 24900463 DOI: 10.1021/Ml200256D |
0.812 |
|
| 2012 |
Sardella R, Gioiello A, Ianni F, Venturoni F, Natalini B. HPLC/ELSD analysis of amidated bile acids: An effective and rapid way to assist continuous flow chemistry processes Talanta. 100: 364-371. PMID 23141350 DOI: 10.1016/J.Talanta.2012.07.092 |
0.403 |
|
| 2012 |
Gioiello A, Rosatelli E, Nuti R, Macchiarulo A, Pellicciari R. Patented TGR5 modulators: a review (2006 - present). Expert Opinion On Therapeutic Patents. 22: 1399-414. PMID 23039746 DOI: 10.1517/13543776.2012.733000 |
0.775 |
|
| 2012 |
Venturoni F, Gioiello A, Sardella R, Natalini B, Pellicciari R. Continuous flow synthesis and scale-up of glycine- and taurine-conjugated bile salts. Organic & Biomolecular Chemistry. 10: 4109-15. PMID 22517166 DOI: 10.1039/C2Ob25528F |
0.703 |
|
| 2012 |
Gioiello A, Sardella R, Rosatelli E, Sadeghpour BM, Natalini B, Pellicciari R. Novel stereoselective synthesis and chromatographic evaluation of E-guggulsterone. Steroids. 77: 250-4. PMID 22155267 DOI: 10.1016/J.Steroids.2011.11.012 |
0.686 |
|
| 2011 |
Pols TW, Nomura M, Harach T, Lo Sasso G, Oosterveer MH, Thomas C, Rizzo G, Gioiello A, Adorini L, Pellicciari R, Auwerx J, Schoonjans K. TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading. Cell Metabolism. 14: 747-57. PMID 22152303 DOI: 10.1016/J.Cmet.2011.11.006 |
0.708 |
|
| 2011 |
Gioiello A, Venturoni F, Marinozzi M, Natalini B, Pellicciari R. Exploring the synthetic versatility of the Lewis acid induced decomposition reaction of α-diazo-β-hydroxy esters. The case of ethyl diazo(3-hydroxy-2-oxo-2,3-dihydro-1H-indol-3-yl)acetate. The Journal of Organic Chemistry. 76: 7431-7. PMID 21800851 DOI: 10.1021/Jo201205U |
0.725 |
|
| 2011 |
Natalini B, Sardella R, Gioiello A, Rosatelli E, Ianni F, Camaioni E, Pellicciari R. Fast chromatographic determination of the bile salt critical micellar concentration. Analytical and Bioanalytical Chemistry. 401: 267-74. PMID 21573726 DOI: 10.1007/S00216-011-5082-4 |
0.738 |
|
| 2011 |
Gioiello A, Macchiarulo A, Carotti A, Filipponi P, Costantino G, Rizzo G, Adorini L, Pellicciari R. Extending SAR of bile acids as FXR ligands: discovery of 23-N-(carbocinnamyloxy)-3α,7α-dihydroxy-6α-ethyl-24-nor-5β-cholan-23-amine. Bioorganic & Medicinal Chemistry. 19: 2650-8. PMID 21459580 DOI: 10.1016/J.Bmc.2011.03.004 |
0.792 |
|
| 2011 |
Pellicciari R, Camaioni E, Gilbert AM, Macchiarulo A, Bikker JA, Shah F, Bard J, Costantino G, Gioiello A, Robertson GM, Sabbatini P, Venturoni F, Liscio P, Carotti A, Bellocchi D, et al. Discovery and characterization of novel potent PARP-1 inhibitors endowed with neuroprotective properties: From TIQ-A to HYDAMTIQ Medchemcomm. 2: 559-565. DOI: 10.1039/C1Md00021G |
0.757 |
|
| 2011 |
Gioiello A, Sabbatini P, Rosatelli E, MacChiarulo A, Pellicciari R. Divergent and stereoselective synthesis of dafachronic acids Tetrahedron. 67: 1924-1929. DOI: 10.1016/J.Tet.2011.01.022 |
0.796 |
|
| 2010 |
Roberti M, Natalini B, Andrisano V, Seraglia R, Gioiello A, Pellicciari R. Thermal and catalytic reactions of ethyl diazopyruvate with [60]fullerene Tetrahedron. 66: 7329-7332. DOI: 10.1016/J.Tet.2010.06.067 |
0.662 |
|
| 2009 |
Pellicciari R, Gioiello A, Macchiarulo A, Thomas C, Rosatelli E, Natalini B, Sardella R, Pruzanski M, Roda A, Pastorini E, Schoonjans K, Auwerx J. Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity. Journal of Medicinal Chemistry. 52: 7958-61. PMID 20014870 DOI: 10.1021/Jm901390P |
0.792 |
|
| 2009 |
Thomas C, Gioiello A, Noriega L, Strehle A, Oury J, Rizzo G, Macchiarulo A, Yamamoto H, Mataki C, Pruzanski M, Pellicciari R, Auwerx J, Schoonjans K. TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metabolism. 10: 167-77. PMID 19723493 DOI: 10.1016/J.Cmet.2009.08.001 |
0.771 |
|
| 2009 |
Natalini B, Sardella R, Gioiello A, Carbone G, Dawgul M, Pellicciari R. Side-chain modified bile acids: chromatographic separation of 23-methyl epimers. Journal of Separation Science. 32: 2022-33. PMID 19548211 DOI: 10.1002/Jssc.200900080 |
0.732 |
|
| 2009 |
Gioiello A, Venturoni F, Natalini B, Pellicciari R. BF(3).Et(2)O-induced decomposition of ethyl 2-diazo-3-hydroxy-3,3-diarylpropanoates in acetonitrile: a novel approach to 2,3-diaryl beta-enamino ester derivatives. The Journal of Organic Chemistry. 74: 3520-3. PMID 19341244 DOI: 10.1021/Jo802775Q |
0.683 |
|
| 2009 |
Natalini B, Sardella R, Camaioni E, Macchiarulo A, Gioiello A, Carbone G, Pellicciari R. Derived chromatographic indices as effective tools to study the self-aggregation process of bile acids. Journal of Pharmaceutical and Biomedical Analysis. 50: 613-21. PMID 19081222 DOI: 10.1016/J.Jpba.2008.10.035 |
0.782 |
|
| 2009 |
Gioiello A, Khamidullina A, Fulco MC, Venturoni F, Zlotsky S, Pellicciari R. New one-pot synthesis of pyrazole-5-carboxylates by 1,3-dipole cycloadditions of ethyl diazoacetate with α-methylene carbonyl compounds Tetrahedron Letters. 50: 5978-5980. DOI: 10.1016/J.Tetlet.2009.07.152 |
0.71 |
|
| 2008 |
Macchiarulo A, Gioiello A, Thomas C, Massarotti A, Nuti R, Rosatelli E, Sabbatini P, Schoonjans K, Auwerx J, Pellicciari R. Molecular field analysis and 3D-quantitative structure-activity relationship study (MFA 3D-QSAR) unveil novel features of bile acid recognition at TGR5. Journal of Chemical Information and Modeling. 48: 1792-801. PMID 18698841 DOI: 10.1021/Ci800196H |
0.799 |
|
| 2008 |
Sato H, Macchiarulo A, Thomas C, Gioiello A, Une M, Hofmann AF, Saladin R, Schoonjans K, Pellicciari R, Auwerx J. Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies. Journal of Medicinal Chemistry. 51: 1831-41. PMID 18307294 DOI: 10.1021/Jm7015864 |
0.814 |
|
| 2007 |
Pellicciari R, Sato H, Gioiello A, Costantino G, Macchiarulo A, Sadeghpour BM, Giorgi G, Schoonjans K, Auwerx J. Nongenomic actions of bile acids. Synthesis and preliminary characterization of 23- and 6,23-alkyl-substituted bile acid derivatives as selective modulators for the G-protein coupled receptor TGR5. Journal of Medicinal Chemistry. 50: 4265-8. PMID 17685603 DOI: 10.1021/Jm070633P |
0.804 |
|
| 2007 |
Natalini B, Sardella R, Camaioni E, Gioiello A, Pellicciari R. Correlation between CMC and chromatographic index: simple and effective evaluation of the hydrophobic/hydrophilic balance of bile acids. Analytical and Bioanalytical Chemistry. 388: 1681-8. PMID 17572887 DOI: 10.1007/S00216-007-1360-6 |
0.718 |
|
| 2007 |
Pellicciari R, Amori L, Kuznetsova N, Zlotsky S, Gioiello A. Indium triflate catalyzed reaction of diisopropyl diazomethylphosphonate with imines as a new approach to cis- and trans-aziridine-2-phosphonates Tetrahedron Letters. 48: 4911-4914. DOI: 10.1016/J.Tetlet.2007.05.042 |
0.693 |
|
| 2006 |
Pellicciari R, Gioiello A, Costantino G, Sadeghpour BM, Rizzo G, Meyer U, Parks DJ, Entrena-Guadix A, Fiorucci S. Back door modulation of the farnesoid X receptor: design, synthesis, and biological evaluation of a series of side chain modified chenodeoxycholic acid derivatives. Journal of Medicinal Chemistry. 49: 4208-15. PMID 16821780 DOI: 10.1021/Jm060294K |
0.741 |
|
| 2006 |
Rizzo G, Disante M, Mencarelli A, Renga B, Gioiello A, Pellicciari R, Fiorucci S. The farnesoid X receptor promotes adipocyte differentiation and regulates adipose cell function in vivo. Molecular Pharmacology. 70: 1164-73. PMID 16778009 DOI: 10.1124/Mol.106.023820 |
0.698 |
|
| 2006 |
Pellicciari R, Gioiello A, Costantino G. Potential therapeutic applications of farnesoid X receptor (FXR) modulators Expert Opinion On Therapeutic Patents. 16: 333-341. DOI: 10.1517/13543776.16.3.333 |
0.75 |
|
| 2005 |
Costantino G, Entrena-Guadix A, Macchiarulo A, Gioiello A, Pellicciari R. Molecular dynamics simulation of the ligand binding domain of farnesoid X receptor. Insights into helix-12 stability and coactivator peptide stabilization in response to agonist binding. Journal of Medicinal Chemistry. 48: 3251-9. PMID 15857131 DOI: 10.1021/Jm049182O |
0.734 |
|
| 2004 |
Pellicciari R, Costantino G, Camaioni E, Sadeghpour BM, Entrena A, Willson TM, Fiorucci S, Clerici C, Gioiello A. Bile acid derivatives as ligands of the farnesoid X receptor. Synthesis, evaluation, and structure-activity relationship of a series of body and side chain modified analogues of chenodeoxycholic acid. Journal of Medicinal Chemistry. 47: 4559-69. PMID 15317466 DOI: 10.1021/Jm049904B |
0.765 |
|
| 2003 |
Ruzziconi R, Ricci G, Gioiello A, Couthon-Gourvès H, Gourvès JP. First general approach to cyclohex-3-ene-1,1-bis(phosphonates) by Diels-Alder cycloaddition of tetraethyl vinylidenebis(phosphonate) to 1,3-dienes. The Journal of Organic Chemistry. 68: 736-42. PMID 12558393 DOI: 10.1021/Jo0205154 |
0.357 |
|
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