Mamoun Alhamadsheh - Publications

Affiliations: 
2011 University of the Pacific, Stockton, CA, United States 
Area:
Chemistry, Biochemistry, Chemical Biology, Molecular Biology, Medicinal Chemistry, Pharmacokinetics
Website:
https://pharmacy.pacific.edu/campus-directory/mamoun-alhamadsheh

24 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Amin TU, Emara R, Pal A, Aldawod H, Jiang G, Liang D, Haque Tuhin MT, Balgoname A, Patel AD, Alhamadsheh MM. Enhancing the Safety and Efficacy of PSMA-Based Small-Molecule Drug Conjugates by Linker Stabilization and Conjugation to Transthyretin Binding Ligand. Journal of Medicinal Chemistry. PMID 36327103 DOI: 10.1021/acs.jmedchem.2c01423  0.695
2019 Pal A, Albusairi W, Liu F, Tuhin MTH, Miller M, Liang D, Joo H, Amin TU, Wilson EA, Faridi JS, Park M, Alhamadsheh MM. Hydrophilic Small Molecules that Harness Transthyretin to Enhance the Safety and Efficacy of Targeted Chemotherapeutic Agents. Molecular Pharmaceutics. PMID 31136717 DOI: 10.1021/Acs.Molpharmaceut.9B00432  0.705
2018 Miller M, Pal A, Albusairi W, Joo H, Pappas B, Haque Tuhin MT, Liang D, Jampala R, Liu F, Khan J, Faaij M, Park M, Chan W, Graef I, Zamboni R, ... ... Alhamadsheh M, et al. Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. Journal of Medicinal Chemistry. PMID 30133284 DOI: 10.1021/Acs.Jmedchem.8B00817  0.707
2017 Alhamadsheh M, Miller M, Pal A, Albusairi W, Graef I, Sinha U, Fox J, Zamboni R, Kumar N. P5846AG10, an orally available, novel transthyretin (TTR) stabilizer: integrated preclinical evaluation predicts a highly effective treatment for TTR amyloid cardiomyopathy European Heart Journal. 38. DOI: 10.1093/Eurheartj/Ehx493.P5846  0.687
2015 Penchala SC, Miller MR, Pal A, Dong J, Madadi NR, Xie J, Joo H, Tsai J, Batoon P, Samoshin V, Franz A, Cox T, Miles J, Chan WK, Park MS, ... Alhamadsheh MM, et al. A biomimetic approach for enhancing the in vivo half-life of peptides. Nature Chemical Biology. 11: 793-8. PMID 26344696 DOI: 10.1038/Nchembio.1907  0.669
2015 Penchala SC, Miller MR, Pal A, Dong J, Madadi NR, Xie J, Joo H, Tsai J, Batoon P, Samoshin V, Franz A, Cox T, Miles J, Chan WK, Park MS, ... Alhamadsheh MM, et al. A biomimetic approach for enhancing the in vivo half-life of peptides Nature Chemical Biology. DOI: 10.1038/nchembio.1907  0.7
2013 Penchala SC, Connelly S, Wang Y, Park MS, Zhao L, Baranczak A, Rappley I, Vogel H, Liedtke M, Witteles RM, Powers ET, Reixach N, Chan WK, Wilson IA, Kelly JW, ... ... Alhamadsheh MM, et al. AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin. Proceedings of the National Academy of Sciences of the United States of America. 110: 9992-7. PMID 23716704 DOI: 10.1073/Pnas.1300761110  0.698
2011 Papireddy K, Smilkstein M, Kelly JX, Shweta, Salem SM, Alhamadsheh M, Haynes SW, Challis GL, Reynolds KA. Antimalarial activity of natural and synthetic prodiginines. Journal of Medicinal Chemistry. 54: 5296-306. PMID 21736388 DOI: 10.1021/Jm200543Y  0.522
2011 Whicher JR, Florova G, Sydor PK, Singh R, Alhamadsheh M, Challis GL, Reynolds KA, Smith JL. Structure and function of the RedJ protein, a thioesterase from the prodiginine biosynthetic pathway in Streptomyces coelicolor. The Journal of Biological Chemistry. 286: 22558-69. PMID 21543318 DOI: 10.1074/Jbc.M110.213512  0.58
2009 Eustáquio AS, McGlinchey RP, Liu Y, Hazzard C, Beer LL, Florova G, Alhamadsheh MM, Lechner A, Kale AJ, Kobayashi Y, Reynolds KA, Moore BS. Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine. Proceedings of the National Academy of Sciences of the United States of America. 106: 12295-300. PMID 19590008 DOI: 10.1073/Pnas.0901237106  0.521
2009 Ghatge MS, Palaniappan N, Alhamadsheh MM, DiBari J, Reynolds KA. Application of a newly identified and characterized 18-o-acyltransferase in chemoenzymatic synthesis of selected natural and nonnatural bioactive derivatives of phoslactomycins. Applied and Environmental Microbiology. 75: 3469-76. PMID 19304832 DOI: 10.1128/Aem.02590-08  0.506
2008 Alhamadsheh MM, Waters NC, Sachdeva S, Lee P, Reynolds KA. Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors. Bioorganic & Medicinal Chemistry Letters. 18: 6402-5. PMID 18996691 DOI: 10.1016/J.Bmcl.2008.10.097  0.723
2008 Palaniappan N, Alhamadsheh MM, Reynolds KA. cis-Delta(2,3)-double bond of phoslactomycins is generated by a post-PKS tailoring enzyme. Journal of the American Chemical Society. 130: 12236-7. PMID 18714992 DOI: 10.1021/Ja8044162  0.471
2008 Turos E, Revell KD, Ramaraju P, Gergeres DA, Greenhalgh K, Young A, Sathyanarayan N, Dickey S, Lim D, Alhamadsheh MM, Reynolds K. Unsymmetric aryl-alkyl disulfide growth inhibitors of methicillin-resistant Staphylococcus aureus and Bacillus anthracis. Bioorganic & Medicinal Chemistry. 16: 6501-8. PMID 18524602 DOI: 10.1016/J.Bmc.2008.05.032  0.525
2008 Sachdeva S, Musayev FN, Alhamadsheh MM, Scarsdale JN, Wright HT, Reynolds KA. Separate entrance and exit portals for ligand traffic in Mycobacterium tuberculosis FabH. Chemistry & Biology. 15: 402-12. PMID 18420147 DOI: 10.1016/J.Chembiol.2008.03.007  0.73
2008 Mo S, Sydor PK, Corre C, Alhamadsheh MM, Stanley AE, Haynes SW, Song L, Reynolds KA, Challis GL. Elucidation of the Streptomyces coelicolor pathway to 2-undecylpyrrole, a key intermediate in undecylprodiginine and streptorubin B biosynthesis. Chemistry & Biology. 15: 137-48. PMID 18291318 DOI: 10.1016/J.Chembiol.2007.11.015  0.473
2008 Sachdeva S, Musayev F, Alhamadsheh MM, Neel Scarsdale J, Tonie Wright H, Reynolds KA. Probing reactivity and substrate specificity of both subunits of the dimeric Mycobacterium tuberculosis FabH using alkyl-CoA disulfide inhibitors and acyl-CoA substrates. Bioorganic Chemistry. 36: 85-90. PMID 18096200 DOI: 10.1016/J.Bioorg.2007.11.001  0.73
2008 Alhamadsheh MM, Gupta S, Hudson RA, Perera L, Tillekeratne LM. Total synthesis and selective activity of a new class of conformationally restrained epothilones. Chemistry (Weinheim An Der Bergstrasse, Germany). 14: 570-81. PMID 17955508 DOI: 10.1002/Chem.200701143  0.746
2008 Gupta S, Rajagopalan M, Alhamadsheh MM, Tillekeratne LMV, Hudson RA. ChemInform Abstract: First Total Synthesis and Absolute Configuration of the Styryl Lactone Gonioheptolide A. Cheminform. 39. DOI: 10.1002/chin.200813202  0.542
2007 Alhamadsheh MM, Musayev F, Komissarov AA, Sachdeva S, Wright HT, Scarsdale N, Florova G, Reynolds KA. Alkyl-CoA disulfides as inhibitors and mechanistic probes for FabH enzymes. Chemistry & Biology. 14: 513-24. PMID 17524982 DOI: 10.1016/J.Chembiol.2007.03.013  0.738
2007 Alhamadsheh MM, Palaniappan N, Daschouduri S, Reynolds KA. Modular polyketide synthases and cis double bond formation: establishment of activated cis-3-cyclohexylpropenoic acid as the diketide intermediate in phoslactomycin biosynthesis. Journal of the American Chemical Society. 129: 1910-1. PMID 17256943 DOI: 10.1021/Ja068818T  0.463
2007 Alhamadsheh MM, Waters NC, Huddler DP, Kreishman-Deitrick M, Florova G, Reynolds KA. Synthesis and biological evaluation of thiazolidine-2-one 1,1-dioxide as inhibitors of Escherichia coli beta-ketoacyl-ACP-synthase III (FabH). Bioorganic & Medicinal Chemistry Letters. 17: 879-83. PMID 17189694 DOI: 10.1016/J.Bmcl.2006.11.067  0.495
2007 Gupta S, Rajagopalan M, Alhamadsheh MM, Tillekeratne LMV, Hudson RA. First total synthesis and absolute configuration of the styryl lactone gonioheptolide A Synthesis. 3512-3518. DOI: 10.1055/S-2007-990862  0.559
2006 Alhamadsheh MM, Hudson RA, Viranga Tillekeratne LM. Design, total synthesis, and evaluation of novel open-chain epothilone analogues. Organic Letters. 8: 685-8. PMID 16468742 DOI: 10.1021/Ol0528787  0.582
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