| Year |
Citation |
Score |
| 2022 |
Amin TU, Emara R, Pal A, Aldawod H, Jiang G, Liang D, Haque Tuhin MT, Balgoname A, Patel AD, Alhamadsheh MM. Enhancing the Safety and Efficacy of PSMA-Based Small-Molecule Drug Conjugates by Linker Stabilization and Conjugation to Transthyretin Binding Ligand. Journal of Medicinal Chemistry. PMID 36327103 DOI: 10.1021/acs.jmedchem.2c01423 |
0.695 |
|
| 2019 |
Pal A, Albusairi W, Liu F, Tuhin MTH, Miller M, Liang D, Joo H, Amin TU, Wilson EA, Faridi JS, Park M, Alhamadsheh MM. Hydrophilic Small Molecules that Harness Transthyretin to Enhance the Safety and Efficacy of Targeted Chemotherapeutic Agents. Molecular Pharmaceutics. PMID 31136717 DOI: 10.1021/Acs.Molpharmaceut.9B00432 |
0.705 |
|
| 2018 |
Miller M, Pal A, Albusairi W, Joo H, Pappas B, Haque Tuhin MT, Liang D, Jampala R, Liu F, Khan J, Faaij M, Park M, Chan W, Graef I, Zamboni R, ... ... Alhamadsheh M, et al. Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. Journal of Medicinal Chemistry. PMID 30133284 DOI: 10.1021/Acs.Jmedchem.8B00817 |
0.707 |
|
| 2017 |
Alhamadsheh M, Miller M, Pal A, Albusairi W, Graef I, Sinha U, Fox J, Zamboni R, Kumar N. P5846AG10, an orally available, novel transthyretin (TTR) stabilizer: integrated preclinical evaluation predicts a highly effective treatment for TTR amyloid cardiomyopathy European Heart Journal. 38. DOI: 10.1093/Eurheartj/Ehx493.P5846 |
0.687 |
|
| 2015 |
Penchala SC, Miller MR, Pal A, Dong J, Madadi NR, Xie J, Joo H, Tsai J, Batoon P, Samoshin V, Franz A, Cox T, Miles J, Chan WK, Park MS, ... Alhamadsheh MM, et al. A biomimetic approach for enhancing the in vivo half-life of peptides. Nature Chemical Biology. 11: 793-8. PMID 26344696 DOI: 10.1038/Nchembio.1907 |
0.669 |
|
| 2015 |
Penchala SC, Miller MR, Pal A, Dong J, Madadi NR, Xie J, Joo H, Tsai J, Batoon P, Samoshin V, Franz A, Cox T, Miles J, Chan WK, Park MS, ... Alhamadsheh MM, et al. A biomimetic approach for enhancing the in vivo half-life of peptides Nature Chemical Biology. DOI: 10.1038/nchembio.1907 |
0.7 |
|
| 2013 |
Penchala SC, Connelly S, Wang Y, Park MS, Zhao L, Baranczak A, Rappley I, Vogel H, Liedtke M, Witteles RM, Powers ET, Reixach N, Chan WK, Wilson IA, Kelly JW, ... ... Alhamadsheh MM, et al. AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin. Proceedings of the National Academy of Sciences of the United States of America. 110: 9992-7. PMID 23716704 DOI: 10.1073/Pnas.1300761110 |
0.698 |
|
| 2011 |
Papireddy K, Smilkstein M, Kelly JX, Shweta, Salem SM, Alhamadsheh M, Haynes SW, Challis GL, Reynolds KA. Antimalarial activity of natural and synthetic prodiginines. Journal of Medicinal Chemistry. 54: 5296-306. PMID 21736388 DOI: 10.1021/Jm200543Y |
0.522 |
|
| 2011 |
Whicher JR, Florova G, Sydor PK, Singh R, Alhamadsheh M, Challis GL, Reynolds KA, Smith JL. Structure and function of the RedJ protein, a thioesterase from the prodiginine biosynthetic pathway in Streptomyces coelicolor. The Journal of Biological Chemistry. 286: 22558-69. PMID 21543318 DOI: 10.1074/Jbc.M110.213512 |
0.58 |
|
| 2009 |
Eustáquio AS, McGlinchey RP, Liu Y, Hazzard C, Beer LL, Florova G, Alhamadsheh MM, Lechner A, Kale AJ, Kobayashi Y, Reynolds KA, Moore BS. Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine. Proceedings of the National Academy of Sciences of the United States of America. 106: 12295-300. PMID 19590008 DOI: 10.1073/Pnas.0901237106 |
0.521 |
|
| 2009 |
Ghatge MS, Palaniappan N, Alhamadsheh MM, DiBari J, Reynolds KA. Application of a newly identified and characterized 18-o-acyltransferase in chemoenzymatic synthesis of selected natural and nonnatural bioactive derivatives of phoslactomycins. Applied and Environmental Microbiology. 75: 3469-76. PMID 19304832 DOI: 10.1128/Aem.02590-08 |
0.506 |
|
| 2008 |
Alhamadsheh MM, Waters NC, Sachdeva S, Lee P, Reynolds KA. Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors. Bioorganic & Medicinal Chemistry Letters. 18: 6402-5. PMID 18996691 DOI: 10.1016/J.Bmcl.2008.10.097 |
0.723 |
|
| 2008 |
Palaniappan N, Alhamadsheh MM, Reynolds KA. cis-Delta(2,3)-double bond of phoslactomycins is generated by a post-PKS tailoring enzyme. Journal of the American Chemical Society. 130: 12236-7. PMID 18714992 DOI: 10.1021/Ja8044162 |
0.471 |
|
| 2008 |
Turos E, Revell KD, Ramaraju P, Gergeres DA, Greenhalgh K, Young A, Sathyanarayan N, Dickey S, Lim D, Alhamadsheh MM, Reynolds K. Unsymmetric aryl-alkyl disulfide growth inhibitors of methicillin-resistant Staphylococcus aureus and Bacillus anthracis. Bioorganic & Medicinal Chemistry. 16: 6501-8. PMID 18524602 DOI: 10.1016/J.Bmc.2008.05.032 |
0.525 |
|
| 2008 |
Sachdeva S, Musayev FN, Alhamadsheh MM, Scarsdale JN, Wright HT, Reynolds KA. Separate entrance and exit portals for ligand traffic in Mycobacterium tuberculosis FabH. Chemistry & Biology. 15: 402-12. PMID 18420147 DOI: 10.1016/J.Chembiol.2008.03.007 |
0.73 |
|
| 2008 |
Mo S, Sydor PK, Corre C, Alhamadsheh MM, Stanley AE, Haynes SW, Song L, Reynolds KA, Challis GL. Elucidation of the Streptomyces coelicolor pathway to 2-undecylpyrrole, a key intermediate in undecylprodiginine and streptorubin B biosynthesis. Chemistry & Biology. 15: 137-48. PMID 18291318 DOI: 10.1016/J.Chembiol.2007.11.015 |
0.473 |
|
| 2008 |
Sachdeva S, Musayev F, Alhamadsheh MM, Neel Scarsdale J, Tonie Wright H, Reynolds KA. Probing reactivity and substrate specificity of both subunits of the dimeric Mycobacterium tuberculosis FabH using alkyl-CoA disulfide inhibitors and acyl-CoA substrates. Bioorganic Chemistry. 36: 85-90. PMID 18096200 DOI: 10.1016/J.Bioorg.2007.11.001 |
0.73 |
|
| 2008 |
Alhamadsheh MM, Gupta S, Hudson RA, Perera L, Tillekeratne LM. Total synthesis and selective activity of a new class of conformationally restrained epothilones. Chemistry (Weinheim An Der Bergstrasse, Germany). 14: 570-81. PMID 17955508 DOI: 10.1002/Chem.200701143 |
0.746 |
|
| 2008 |
Gupta S, Rajagopalan M, Alhamadsheh MM, Tillekeratne LMV, Hudson RA. ChemInform Abstract: First Total Synthesis and Absolute Configuration of the Styryl Lactone Gonioheptolide A. Cheminform. 39. DOI: 10.1002/chin.200813202 |
0.542 |
|
| 2007 |
Alhamadsheh MM, Musayev F, Komissarov AA, Sachdeva S, Wright HT, Scarsdale N, Florova G, Reynolds KA. Alkyl-CoA disulfides as inhibitors and mechanistic probes for FabH enzymes. Chemistry & Biology. 14: 513-24. PMID 17524982 DOI: 10.1016/J.Chembiol.2007.03.013 |
0.738 |
|
| 2007 |
Alhamadsheh MM, Palaniappan N, Daschouduri S, Reynolds KA. Modular polyketide synthases and cis double bond formation: establishment of activated cis-3-cyclohexylpropenoic acid as the diketide intermediate in phoslactomycin biosynthesis. Journal of the American Chemical Society. 129: 1910-1. PMID 17256943 DOI: 10.1021/Ja068818T |
0.463 |
|
| 2007 |
Alhamadsheh MM, Waters NC, Huddler DP, Kreishman-Deitrick M, Florova G, Reynolds KA. Synthesis and biological evaluation of thiazolidine-2-one 1,1-dioxide as inhibitors of Escherichia coli beta-ketoacyl-ACP-synthase III (FabH). Bioorganic & Medicinal Chemistry Letters. 17: 879-83. PMID 17189694 DOI: 10.1016/J.Bmcl.2006.11.067 |
0.495 |
|
| 2007 |
Gupta S, Rajagopalan M, Alhamadsheh MM, Tillekeratne LMV, Hudson RA. First total synthesis and absolute configuration of the styryl lactone gonioheptolide A Synthesis. 3512-3518. DOI: 10.1055/S-2007-990862 |
0.559 |
|
| 2006 |
Alhamadsheh MM, Hudson RA, Viranga Tillekeratne LM. Design, total synthesis, and evaluation of novel open-chain epothilone analogues. Organic Letters. 8: 685-8. PMID 16468742 DOI: 10.1021/Ol0528787 |
0.582 |
|
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