Matthew D. Scharff - Publications

Affiliations: 
Cell Biology Albert Einstein College of Medicine, New York, New York, United States 
Area:
molecular and biochemical mechanisms of antibody variable region hypermutation and class switch recombination
Website:
http://www.einstein.yu.edu/faculty/1450/matthew-scharff/

227 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Wei L, Chahwan R, Wang S, Wang X, Pham PT, Goodman MF, Bergman A, Scharff MD, MacCarthy T. Overlapping hotspots in CDRs are critical sites for V region diversification. Proceedings of the National Academy of Sciences of the United States of America. 112: E728-37. PMID 25646473 DOI: 10.1073/pnas.1500788112  1
2014 Wang X, Fan M, Kalis S, Wei L, Scharff MD. A source of the single-stranded DNA substrate for activation-induced deaminase during somatic hypermutation. Nature Communications. 5: 4137. PMID 24923561 DOI: 10.1038/ncomms5137  1
2014 Varshney AK, Wang X, Aguilar JL, Scharff MD, Fries BC. Isotype switching increases efficacy of antibody protection against staphylococcal enterotoxin B-induced lethal shock and Staphylococcus aureus sepsis in mice. Mbio. 5: e01007-14. PMID 24917594 DOI: 10.1128/mBio.01007-14  1
2014 Aguilar JL, Varshney AK, Wang X, Stanford L, Scharff M, Fries BC. Detection and measurement of staphylococcal enterotoxin-like K (SEl-K) secretion by Staphylococcus aureus clinical isolates. Journal of Clinical Microbiology. 52: 2536-43. PMID 24808237 DOI: 10.1128/JCM.00387-14  1
2014 van Oers JM, Edwards Y, Chahwan R, Zhang W, Smith C, Pechuan X, Schaetzlein S, Jin B, Wang Y, Bergman A, Scharff MD, Edelmann W. The MutSβ complex is a modulator of p53-driven tumorigenesis through its functions in both DNA double-strand break repair and mismatch repair. Oncogene. 33: 3939-46. PMID 24013230 DOI: 10.1038/onc.2013.365  1
2013 Varshney AK, Wang X, Scharff MD, MacIntyre J, Zollner RS, Kovalenko OV, Martinez LR, Byrne FR, Fries BC. Staphylococcal Enterotoxin B-specific monoclonal antibody 20B1 successfully treats diverse Staphylococcus aureus infections. The Journal of Infectious Diseases. 208: 2058-66. PMID 23922375 DOI: 10.1093/infdis/jit421  1
2013 Schaetzlein S, Chahwan R, Avdievich E, Roa S, Wei K, Eoff RL, Sellers RS, Clark AB, Kunkel TA, Scharff MD, Edelmann W. Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes. Proceedings of the National Academy of Sciences of the United States of America. 110: E2470-9. PMID 23754438 DOI: 10.1073/pnas.1308512110  1
2013 Zhao R, Chinai JM, Buhl S, Scandiuzzi L, Ray A, Jeon H, Ohaegbulam KC, Ghosh K, Zhao A, Scharff MD, Zang X. HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T-cell function. Proceedings of the National Academy of Sciences of the United States of America. 110: 9879-84. PMID 23716685 DOI: 10.1073/pnas.1303524110  1
2013 Jaszczur M, Bertram JG, Pham P, Scharff MD, Goodman MF. AID and Apobec3G haphazard deamination and mutational diversity. Cellular and Molecular Life Sciences : Cmls. 70: 3089-108. PMID 23178850 DOI: 10.1007/s00018-012-1212-1  1
2012 Patten PE, Chu CC, Albesiano E, Damle RN, Yan XJ, Kim D, Zhang L, Magli AR, Barrientos J, Kolitz JE, Allen SL, Rai KR, Roa S, Mongini PK, MacCarthy T, ... Scharff MD, et al. IGHV-unmutated and IGHV-mutated chronic lymphocytic leukemia cells produce activation-induced deaminase protein with a full range of biologic functions. Blood. 120: 4802-11. PMID 23071276 DOI: 10.1182/blood-2012-08-449744  1
2012 Chahwan R, Edelmann W, Scharff MD, Roa S. AIDing antibody diversity by error-prone mismatch repair. Seminars in Immunology. 24: 293-300. PMID 22703640 DOI: 10.1016/j.smim.2012.05.005  1
2012 Chahwan R, van Oers JM, Avdievich E, Zhao C, Edelmann W, Scharff MD, Roa S. The ATPase activity of MLH1 is required to orchestrate DNA double-strand breaks and end processing during class switch recombination. The Journal of Experimental Medicine. 209: 671-8. PMID 22451719 DOI: 10.1084/jem.20111531  1
2012 Volpi SA, Verma-Gaur J, Hassan R, Ju Z, Roa S, Chatterjee S, Werling U, Hou H, Will B, Steidl U, Scharff M, Edelman W, Feeney AJ, Birshtein BK. Germline deletion of Igh 3' regulatory region elements hs 5, 6, 7 (hs5-7) affects B cell-specific regulation, rearrangement, and insulation of the Igh locus. Journal of Immunology (Baltimore, Md. : 1950). 188: 2556-66. PMID 22345664 DOI: 10.4049/jimmunol.1102763  1
2012 Sroubek J, Krishnan Y, Chinai J, Buhl S, Scharff MD, McDonald TV. The use of Bcl-2 over-expression to stabilize hybridomas specific to the HERG potassium channel. Journal of Immunological Methods. 375: 215-22. PMID 22107967 DOI: 10.1016/j.jim.2011.10.014  1
2011 Chahwan R, Edelmann W, Scharff MD, Roa S. Mismatch-mediated error prone repair at the immunoglobulin genes. Biomedicine & Pharmacotherapy = BioméDecine & PharmacothéRapie. 65: 529-36. PMID 22100214 DOI: 10.1016/j.biopha.2011.09.001  1
2011 Baughn LB, Kalis SL, MacCarthy T, Wei L, Fan M, Bergman A, Scharff MD. Recombinase-mediated cassette exchange as a novel method to study somatic hypermutation in Ramos cells. Mbio. 2. PMID 21990614 DOI: 10.1128/mBio.00186-11  1
2011 Calissano C, Damle RN, Marsilio S, Yan XJ, Yancopoulos S, Hayes G, Emson C, Murphy EJ, Hellerstein MK, Sison C, Kaufman MS, Kolitz JE, Allen SL, Rai KR, Ivanovic I, ... ... Scharff MD, et al. Intraclonal complexity in chronic lymphocytic leukemia: fractions enriched in recently born/divided and older/quiescent cells. Molecular Medicine (Cambridge, Mass.). 17: 1374-82. PMID 21968788 DOI: 10.2119/molmed.2011.00360  1
2011 Varshney AK, Wang X, Cook E, Dutta K, Scharff MD, Goger MJ, Fries BC. Generation, characterization, and epitope mapping of neutralizing and protective monoclonal antibodies against staphylococcal enterotoxin B-induced lethal shock. The Journal of Biological Chemistry. 286: 9737-47. PMID 21233204 DOI: 10.1074/jbc.M110.212407  1
2010 Peled JU, Sellers RS, Iglesias-Ussel MD, Shin DM, Montagna C, Zhao C, Li Z, Edelmann W, Morse HC, Scharff MD. Msh6 protects mature B cells from lymphoma by preserving genomic stability. The American Journal of Pathology. 177: 2597-608. PMID 20934970 DOI: 10.2353/ajpath.2010.100234  1
2010 Abboud N, Chow SK, Saylor C, Janda A, Ravetch JV, Scharff MD, Casadevall A. A requirement for FcγR in antibody-mediated bacterial toxin neutralization. The Journal of Experimental Medicine. 207: 2395-405. PMID 20921285 DOI: 10.1084/jem.20100995  1
2010 van Oers JM, Roa S, Werling U, Liu Y, Genschel J, Hou H, Sellers RS, Modrich P, Scharff MD, Edelmann W. PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance. Proceedings of the National Academy of Sciences of the United States of America. 107: 13384-9. PMID 20624957 DOI: 10.1073/pnas.1008589107  1
2010 Roa S, Li Z, Peled JU, Zhao C, Edelmann W, Scharff MD. MSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sites. Plos One. 5: e11182. PMID 20567595 DOI: 10.1371/journal.pone.0011182  1
2010 Peled JU, Yu JJ, Venkatesh J, Bi E, Ding BB, Krupski-Downs M, Shaknovich R, Sicinski P, Diamond B, Scharff MD, Ye BH. Requirement for cyclin D3 in germinal center formation and function. Cell Research. 20: 631-46. PMID 20404856 DOI: 10.1038/cr.2010.55  1
2010 Ramachandran S, Chahwan R, Nepal RM, Frieder D, Panier S, Roa S, Zaheen A, Durocher D, Scharff MD, Martin A. The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination. Proceedings of the National Academy of Sciences of the United States of America. 107: 809-14. PMID 20080757 DOI: 10.1073/pnas.0913790107  1
2009 Iglesias-Ussel MD, Zavadil J, Scharff MD. Molecular characterization of hybridoma subclones spontaneously switching at high frequencies in vitro. Journal of Immunological Methods. 350: 71-8. PMID 19619554 DOI: 10.1016/j.jim.2009.07.003  1
2009 MacCarthy T, Kalis SL, Roa S, Pham P, Goodman MF, Scharff MD, Bergman A. V-region mutation in vitro, in vivo, and in silico reveal the importance of the enzymatic properties of AID and the sequence environment. Proceedings of the National Academy of Sciences of the United States of America. 106: 8629-34. PMID 19443686 DOI: 10.1073/pnas.0903803106  1
2009 Kuang FL, Luo Z, Scharff MD. H3 trimethyl K9 and H3 acetyl K9 chromatin modifications are associated with class switch recombination. Proceedings of the National Academy of Sciences of the United States of America. 106: 5288-93. PMID 19276123 DOI: 10.1073/pnas.0901368106  1
2009 Maccarthy T, Roa S, Scharff MD, Bergman A. SHMTool: a webserver for comparative analysis of somatic hypermutation datasets. Dna Repair. 8: 137-41. PMID 18952008 DOI: 10.1016/j.dnarep.2008.09.006  1
2008 Roa S, Avdievich E, Peled JU, Maccarthy T, Werling U, Kuang FL, Kan R, Zhao C, Bergman A, Cohen PE, Edelmann W, Scharff MD. Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression. Proceedings of the National Academy of Sciences of the United States of America. 105: 16248-53. PMID 18854411 DOI: 10.1073/pnas.0808182105  1
2008 Roa S, Kuang FL, Scharff MD. Does antisense make sense of AID targeting? Proceedings of the National Academy of Sciences of the United States of America. 105: 3661-2. PMID 18322011 DOI: 10.1073/pnas.0800935105  1
2008 Peled JU, Kuang FL, Iglesias-Ussel MD, Roa S, Kalis SL, Goodman MF, Scharff MD. The biochemistry of somatic hypermutation. Annual Review of Immunology. 26: 481-511. PMID 18304001 DOI: 10.1146/annurev.immunol.26.021607.090236  1
2008 Batova I, Kowal C, May R, Scharff MD, Diamond B. Human recombinant Fab fragments with sub-nanomolar affinities for acetylated histones. Journal of Immunological Methods. 329: 1-10. PMID 17976637 DOI: 10.1016/j.jim.2007.08.019  1
2007 Goodman MF, Scharff MD, Romesberg FE. AID-initiated purposeful mutations in immunoglobulin genes. Advances in Immunology. 94: 127-55. PMID 17560274 DOI: 10.1016/S0065-2776(06)94005-X  1
2007 Li Z, Luo Z, Ronai D, Kuang FL, Peled JU, Iglesias-Ussel MD, Scharff MD. Targeting AID to the Ig genes. Advances in Experimental Medicine and Biology. 596: 93-109. PMID 17338179 DOI: 10.1007/0-387-46530-8_9  1
2007 Ronai D, Iglesias-Ussel MD, Fan M, Li Z, Martin A, Scharff MD. Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation. The Journal of Experimental Medicine. 204: 181-90. PMID 17227912 DOI: 10.1084/jem.20062032  1
2007 Iglesias-Ussel MD, Ziqiang L, Scharff MD. Mouse Models revealed the Mechanisms for Somatic Hypermutation and Class Switch Recombination of Immunoglobulin Genes The Mouse in Biomedical Research. 4: 155-168. DOI: 10.1016/B978-012369454-6/50083-2  1
2006 Iglesias-Ussel MD, Fan M, Li Z, Martin A, Scharff MD. Forced expression of AID facilitates the isolation of class switch variants from hybridoma cells. Journal of Immunological Methods. 316: 59-66. PMID 16997317 DOI: 10.1016/j.jim.2006.08.002  1
2006 Li Z, Zhao C, Iglesias-Ussel MD, Polonskaya Z, Zhuang M, Yang G, Luo Z, Edelmann W, Scharff MD. The mismatch repair protein Msh6 influences the in vivo AID targeting to the Ig locus. Immunity. 24: 393-403. PMID 16618598 DOI: 10.1016/j.immuni.2006.02.011  1
2006 Li Z, Peled JU, Zhao C, Svetlanov A, Ronai D, Cohen PE, Scharff MD. A role for Mlh3 in somatic hypermutation. Dna Repair. 5: 675-82. PMID 16564751 DOI: 10.1016/j.dnarep.2006.02.003  1
2006 Laskov R, Berger N, Scharff MD, Horwitz MS. Tumor necrosis factor-alpha and CD40L modulate cell surface morphology and induce aggregation in Ramos Burkitt's lymphoma cells. Leukemia & Lymphoma. 47: 507-19. PMID 16523591 DOI: 10.1080/10428190500221454  1
2005 Ronai D, Iglesias-Ussel MD, Fan M, Shulman MJ, Scharff MD. Complex regulation of somatic hypermutation by cis-acting sequences in the endogenous IgH gene in hybridoma cells. Proceedings of the National Academy of Sciences of the United States of America. 102: 11829-34. PMID 16087866 DOI: 10.1073/pnas.0505449102  1
2005 Goodman MF, Scharff MD. Identifying protein-protein interactions in somatic hypermutation. The Journal of Experimental Medicine. 201: 493-6. PMID 15710655 DOI: 10.1084/jem.20050161  1
2005 Torres M, May R, Scharff MD, Casadevall A. Variable-region-identical antibodies differing in isotype demonstrate differences in fine specificity and idiotype. Journal of Immunology (Baltimore, Md. : 1950). 174: 2132-42. PMID 15699144  1
2005 Larijani M, Frieder D, Sonbuchner TM, Bransteitter R, Goodman MF, Bouhassira EE, Scharff MD, Martin A. Methylation protects cytidines from AID-mediated deamination. Molecular Immunology. 42: 599-604. PMID 15607819 DOI: 10.1016/j.molimm.2004.09.007  1
2004 Li Z, Luo Z, Scharff MD. Differential regulation of histone acetylation and generation of mutations in switch regions is associated with Ig class switching. Proceedings of the National Academy of Sciences of the United States of America. 101: 15428-33. PMID 15486086 DOI: 10.1073/pnas.0406827101  1
2004 Luo Z, Ronai D, Scharff MD. The role of activation-induced cytidine deaminase in antibody diversification, immunodeficiency, and B-cell malignancies. The Journal of Allergy and Clinical Immunology. 114: 726-35; quiz 736. PMID 15480307 DOI: 10.1016/j.jaci.2004.07.049  1
2004 Li Z, Scherer SJ, Ronai D, Iglesias-Ussel MD, Peled JU, Bardwell PD, Zhuang M, Lee K, Martin A, Edelmann W, Scharff MD. Examination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversification. The Journal of Experimental Medicine. 200: 47-59. PMID 15238604 DOI: 10.1084/jem.20040355  1
2004 Li Z, Woo CJ, Iglesias-Ussel MD, Ronai D, Scharff MD. The generation of antibody diversity through somatic hypermutation and class switch recombination. Genes & Development. 18: 1-11. PMID 14724175 DOI: 10.1101/gad.1161904  1
2004 Bardwell PD, Woo CJ, Wei K, Li Z, Martin A, Sack SZ, Parris T, Edelmann W, Scharff MD. Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice. Nature Immunology. 5: 224-9. PMID 14716311 DOI: 10.1038/ni1031  1
2003 Martin A, Li Z, Lin DP, Bardwell PD, Iglesias-Ussel MD, Edelmann W, Scharff MD. Msh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombination. The Journal of Experimental Medicine. 198: 1171-8. PMID 14568978 DOI: 10.1084/jem.20030880  1
2003 May RJ, Beenhouwer DO, Scharff MD. Antibodies to keyhole limpet hemocyanin cross-react with an epitope on the polysaccharide capsule of Cryptococcus neoformans and other carbohydrates: implications for vaccine development. Journal of Immunology (Baltimore, Md. : 1950). 171: 4905-12. PMID 14568972  1
2003 Woo CJ, Martin A, Scharff MD. Induction of somatic hypermutation is associated with modifications in immunoglobulin variable region chromatin. Immunity. 19: 479-89. PMID 14563313 DOI: 10.1016/S1074-7613(03)00261-9  1
2003 Li Z, Woo CJ, Scharff MD. Mutations in AID and UNG extend the function of AID. Nature Immunology. 4: 945-6. PMID 14515126 DOI: 10.1038/ni1003-945  1
2003 Bardwell PD, Martin A, Wong E, Li Z, Edelmann W, Scharff MD. Cutting edge: the G-U mismatch glycosylase methyl-CpG binding domain 4 is dispensable for somatic hypermutation and class switch recombination. Journal of Immunology (Baltimore, Md. : 1950). 170: 1620-4. PMID 12574322  1
2002 Beenhouwer DO, May RJ, Valadon P, Scharff MD. High affinity mimotope of the polysaccharide capsule of Cryptococcus neoformans identified from an evolutionary phage peptide library. Journal of Immunology (Baltimore, Md. : 1950). 169: 6992-9. PMID 12471134  1
2002 Martin A, Scharff MD. Somatic hypermutation of the AID transgene in B and non-B cells. Proceedings of the National Academy of Sciences of the United States of America. 99: 12304-8. PMID 12202747 DOI: 10.1073/pnas.192442899  1
2002 Song X, Shapiro S, Goldman DL, Casadevall A, Scharff M, Lee SC. Fcgamma receptor I- and III-mediated macrophage inflammatory protein 1alpha induction in primary human and murine microglia. Infection and Immunity. 70: 5177-84. PMID 12183568 DOI: 10.1128/IAI.70.9.5177-5184.2002  1
2002 Martin A, Scharff MD. AID and mismatch repair in antibody diversification. Nature Reviews. Immunology. 2: 605-14. PMID 12154379 DOI: 10.1038/nri858  1
2002 Bardwell PD, Martin A, Scharff MD. Mutation detection of immunoglobulin V-regions by DHPLC. Journal of Immunological Methods. 266: 165-73. PMID 12133633 DOI: 10.1016/S0022-1759(02)00147-3  1
2002 Shapiro S, Beenhouwer DO, Feldmesser M, Taborda C, Carroll MC, Casadevall A, Scharff MD. Immunoglobulin G monoclonal antibodies to Cryptococcus neoformans protect mice deficient in complement component C3. Infection and Immunity. 70: 2598-604. PMID 11953401 DOI: 10.1128/IAI.70.5.2598-2604.2002  1
2002 Martin A, Bardwell PD, Woo CJ, Fan M, Shulman MJ, Scharff MD. Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas. Nature. 415: 802-6. PMID 11823785 DOI: 10.1038/nature714  1
2001 Sack SZ, Bardwell PD, Scharff MD. Testing the reverse transcriptase model of somatic mutation. Molecular Immunology. 38: 303-11. PMID 11566323 DOI: 10.1016/S0161-5890(01)00058-X  1
2001 Beenhouwer DO, Shapiro S, Feldmesser M, Casadevall A, Scharff MD. Both Th1 and Th2 cytokines affect the ability of monoclonal antibodies to protect mice against Cryptococcus neoformans. Infection and Immunity. 69: 6445-55. PMID 11553589 DOI: 10.1128/IAI.69.10.6445-6455.2001  1
2001 Martin A, Scharff MD. Immunology. Antibody alterations. Nature. 412: 870-1. PMID 11528462 DOI: 10.1038/35091184  1
2001 Zhang W, Bardwell PD, Woo CJ, Poltoratsky V, Scharff MD, Martin A. Clonal instability of V region hypermutation in the Ramos Burkitt's lymphoma cell line. International Immunology. 13: 1175-84. PMID 11526098  1
2001 Poltoratsky V, Woo CJ, Tippin B, Martin A, Goodman MF, Scharff MD. Expression of error-prone polymerases in BL2 cells activated for Ig somatic hypermutation. Proceedings of the National Academy of Sciences of the United States of America. 98: 7976-81. PMID 11427727 DOI: 10.1073/pnas.141222198  1
2000 Zuckier LS, Berkowitz EZ, Sattenberg RJ, Zhao QH, Deng HF, Scharff MD. Influence of affinity and antigen density on antibody localization in a modifiable tumor targeting model. Cancer Research. 60: 7008-13. PMID 11156404  1
2000 Poltoratsky V, Goodman MF, Scharff MD. Error-prone candidates vie for somatic mutation. The Journal of Experimental Medicine. 192: F27-30. PMID 11085756  1
2000 Wiesendanger M, Kneitz B, Edelmann W, Scharff MD. Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern. The Journal of Experimental Medicine. 191: 579-84. PMID 10662804 DOI: 10.1084/jem.191.3.579  1
1999 Nussbaum G, Anandasabapathy S, Mukherjee J, Fan M, Casadevall A, Scharff MD. Molecular and idiotypic analyses of the antibody response to Cryptococcus neoformans glucuronoxylomannan-protein conjugate vaccine in autoimmune and nonautoimmune mice. Infection and Immunity. 67: 4469-76. PMID 10456888  1
1998 Zuckier LS, Chang CJ, Scharff MD, Morrison SL. Chimeric human-mouse IgG antibodies with shuffled constant region exons demonstrate that multiple domains contribute to in vivo half-life. Cancer Research. 58: 3905-8. PMID 9731501  1
1998 Wiesendanger M, Scharff MD, Edelmann W. Somatic hypermutation, transcription, and DNA mismatch repair. Cell. 94: 415-8. PMID 9727483  1
1998 Lin MM, Green NS, Zhang W, Scharff MD. The effects of E mu, 3'alpha (hs 1,2) and 3'kappa enhancers on mutation of an Ig-VDJ-Cgamma2a Ig heavy gene in cultured B cells. International Immunology. 10: 1121-9. PMID 9723698 DOI: 10.1093/intimm/10.8.1121  1
1998 Valadon P, Nussbaum G, Oh J, Scharff MD. Aspects of antigen mimicry revealed by immunization with a peptide mimetic of Cryptococcus neoformans polysaccharide. Journal of Immunology (Baltimore, Md. : 1950). 161: 1829-36. PMID 9712050  1
1998 Green NS, Lin MM, Scharff MD. Somatic hypermutation of antibody genes: a hot spot warms up. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 20: 227-34. PMID 9631650 DOI: 10.1002/(SICI)1521-1878(199803)20:3<227::AID-BIES6>3.0.CO;2-O  1
1998 Casadevall A, Cleare W, Feldmesser M, Glatman-Freedman A, Goldman DL, Kozel TR, Lendvai N, Mukherjee J, Pirofski LA, Rivera J, Rosas AL, Scharff MD, Valadon P, Westin K, Zhong Z. Characterization of a murine monoclonal antibody to Cryptococcus neoformans polysaccharide that is a candidate for human therapeutic studies. Antimicrobial Agents and Chemotherapy. 42: 1437-46. PMID 9624491  1
1998 Green NS, Lin MM, Scharff MD. Immunoglobulin hypermutation in cultured cells. Immunological Reviews. 162: 77-87. PMID 9602354 DOI: 10.1111/j.1600-065X.1998.tb01431.x  1
1998 Yuan RR, Spira G, Oh J, Paizi M, Casadevall A, Scharff MD. Isotype switching increases efficacy of antibody protection against Cryptococcus neoformans infection in mice. Infection and Immunity. 66: 1057-62. PMID 9488395  1
1998 Yuan R, Clynes R, Oh J, Ravetch JV, Scharff MD. Antibody-mediated modulation of Cryptococcus neoformans infection is dependent on distinct Fc receptor functions and IgG subclasses. The Journal of Experimental Medicine. 187: 641-8. PMID 9463414 DOI: 10.1084/jem.187.4.641  1
1997 Young AC, Valadon P, Casadevall A, Scharff MD, Sacchettini JC. The three-dimensional structures of a polysaccharide binding antibody to Cryptococcus neoformans and its complex with a peptide from a phage display library: implications for the identification of peptide mimotopes. Journal of Molecular Biology. 274: 622-34. PMID 9417940 DOI: 10.1006/jmbi.1997.1407  1
1997 Lin MM, Zhu M, Scharff MD. Sequence dependent hypermutation of the immunoglobulin heavy chain in cultured B cells. Proceedings of the National Academy of Sciences of the United States of America. 94: 5284-9. PMID 9144229 DOI: 10.1073/pnas.94.10.5284  1
1997 Yuan RR, Casadevall A, Oh J, Scharff MD. T cells cooperate with passive antibody to modify Cryptococcus neoformans infection in mice. Proceedings of the National Academy of Sciences of the United States of America. 94: 2483-8. PMID 9122221 DOI: 10.1073/pnas.94.6.2483  1
1997 Gaynor B, Putterman C, Valadon P, Spatz L, Scharff MD, Diamond B. Peptide inhibition of glomerular deposition of an anti-DNA antibody. Proceedings of the National Academy of Sciences of the United States of America. 94: 1955-60. PMID 9050886 DOI: 10.1073/pnas.94.5.1955  1
1997 Nussbaum G, Cleare W, Casadevall A, Scharff MD, Valadon P. Epitope location in the Cryptococcus neoformans capsule is a determinant of antibody efficacy. The Journal of Experimental Medicine. 185: 685-94. PMID 9034147 DOI: 10.1084/jem.185.4.685  1
1997 Scharff MD, Poltoratsky V, Green NS. The promotion of V region hypermutation. The Journal of Experimental Medicine. 185: 185-8. PMID 9016867 DOI: 10.1084/jem.185.2.185  1
1996 Lin M, Spira G, Scharff MD. Molecular comparison of cultured hybridoma cells that switch isotypes at high and low rates. Somatic Cell and Molecular Genetics. 22: 329-40. PMID 9000175 DOI: 10.1007/BF02369570  1
1996 Valadon P, Scharff MD. Enhancement of ELISAs for screening peptides in epitope phage display libraries. Journal of Immunological Methods. 197: 171-9. PMID 8890904 DOI: 10.1016/0022-1759(96)00133-0  1
1996 Valadon P, Nussbaum G, Boyd LF, Margulies DH, Scharff MD. Peptide libraries define the fine specificity of anti-polysaccharide antibodies to Cryptococcus neoformans. Journal of Molecular Biology. 261: 11-22. PMID 8760499 DOI: 10.1006/jmbi.1996.0438  1
1996 Nussbaum G, Yuan R, Casadevall A, Scharff MD. Immunoglobulin G3 blocking antibodies to the fungal pathogen Cryptococcus neoformans. The Journal of Experimental Medicine. 183: 1905-9. PMID 8666947 DOI: 10.1084/jem.183.4.1905  1
1996 Zhu M, Green NS, Rabinowitz JL, Scharff MD. Differential V region mutation of two transfected Ig genes and their interaction in cultured B cell lines. The Embo Journal. 15: 2738-47. PMID 8654371  1
1995 Yuan R, Casadevall A, Spira G, Scharff MD. Isotype switching from IgG3 to IgG1 converts a nonprotective murine antibody to Cryptococcus neoformans into a protective antibody. Journal of Immunology (Baltimore, Md. : 1950). 154: 1810-6. PMID 7836766  1
1995 Mukherjee J, Nussbaum G, Scharff MD, Casadevall A. Protective and nonprotective monoclonal antibodies to Cryptococcus neoformans originating from one B cell. The Journal of Experimental Medicine. 181: 405-9. PMID 7807020 DOI: 10.1084/jem.181.1.405  1
1995 Zhu M, Rabinowitz JL, Green NS, Kobrin BJ, Scharff MD. A well-differentiated B-cell line is permissive for somatic mutation of a transfected immunoglobulin heavy-chain gene. Proceedings of the National Academy of Sciences of the United States of America. 92: 2810-4. PMID 7708729 DOI: 10.1073/pnas.92.7.2810  1
1995 Mukherjee J, Scharff MD, Casadevall A. Variable efficacy of passive antibody administration against diverse Cryptococcus neoformans strains. Infection and Immunity. 63: 3353-9. PMID 7642262  1
1995 Green NS, Rabinowitz JL, Zhu M, Kobrin BJ, Scharff MD. Immunoglobulin variable region hypermutation in hybrids derived from a pre-B- and a myeloma cell line. Proceedings of the National Academy of Sciences of the United States of America. 92: 6304-8. PMID 7603987 DOI: 10.1073/pnas.92.14.6304  1
1995 Casadevall A, Scharff MD. Return to the past: the case for antibody-based therapies in infectious diseases. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 21: 150-61. PMID 7578724 DOI: 10.1093/clinids/21.1.150  1
1995 Mukherjee J, Feldmesser M, Scharff MD, Casadevall A. Monoclonal antibodies to Cryptococcus neoformans glucuronoxylomannan enhance fluconazole efficacy. Antimicrobial Agents and Chemotherapy. 39: 1398-405. PMID 7492075  1
1994 Zuckier LS, Georgescu L, Chang CJ, Scharff MD, Morrison SL. The use of severe combined immunodeficiency mice to study the metabolism of human immunoglobulin G. Cancer. 73: 794-9. PMID 8306262  1
1994 Mukherjee J, Zuckier LS, Scharff MD, Casadevall A. Therapeutic efficacy of monoclonal antibodies to Cryptococcus neoformans glucuronoxylomannan alone and in combination with amphotericin B. Antimicrobial Agents and Chemotherapy. 38: 580-7. PMID 8203858  1
1994 Spira G, Gregor P, Aguila HL, Scharff MD. Clonal variants of hybridoma cells that switch isotype at a high frequency. Proceedings of the National Academy of Sciences of the United States of America. 91: 3423-7. PMID 8159763  1
1994 Mukherjee S, Lee S, Mukherjee J, Scharff MD, Casadevall A. Monoclonal antibodies to Cryptococcus neoformans capsular polysaccharide modify the course of intravenous infection in mice. Infection and Immunity. 62: 1079-88. PMID 8112842  1
1994 Mukherjee J, Scharff MD, Casadevall A. Cryptococcus neoformans infection can elicit protective antibodies in mice. Canadian Journal of Microbiology. 40: 888-92. PMID 8000967  1
1994 Casadevall A, Scharff MD. Serum therapy revisited: animal models of infection and development of passive antibody therapy. Antimicrobial Agents and Chemotherapy. 38: 1695-702. PMID 7985997  1
1994 Zebedee SL, Koduri RK, Mukherjee J, Mukherjee S, Lee S, Sauer DF, Scharff MD, Casadevall A. Mouse-human immunoglobulin G1 chimeric antibodies with activities against Cryptococcus neoformans. Antimicrobial Agents and Chemotherapy. 38: 1507-14. PMID 7979280  1
1994 Kobrin BJ, Schiff C, Zivion D, Scharff MD, Spira G. In vitro activation of a nonproductive immunoglobulin allele by a single base pair insertion. Hybridoma. 13: 257-61. PMID 7806247  1
1993 Mukherjee J, Pirofski LA, Scharff MD, Casadevall A. Antibody-mediated protection in mice with lethal intracerebral Cryptococcus neoformans infection. Proceedings of the National Academy of Sciences of the United States of America. 90: 3636-40. PMID 8475112  1
1993 Mukherjee J, Casadevall A, Scharff MD. Molecular characterization of the humoral responses to Cryptococcus neoformans infection and glucuronoxylomannan-tetanus toxoid conjugate immunization. The Journal of Experimental Medicine. 177: 1105-16. PMID 8459205  1
1993 Mukherjee J, Casadevall A, Scharff MD. Mu switch region deletion is associated with both T cell independent and T cell dependent responses. Molecular Immunology. 30: 1049-55. PMID 8350875 DOI: 10.1016/0161-5890(93)90130-4  1
1993 Spira G, Gregor PD, Scharff MD. The use of chemiluminescence and the ELISA spot assay to identify and enumerate rare immunoglobulin switch variants. Journal of Immunological Methods. 165: 263-8. PMID 8228276 DOI: 10.1016/0022-1759(93)90352-8  1
1993 Pirofski LA, Thomas EK, Scharff MD. Variable region gene utilization and mutation in a group of neutralizing murine anti-human immunodeficiency virus type 1 principal neutralizing determinant antibodies. Aids Research and Human Retroviruses. 9: 41-9. PMID 7678971  1
1992 Rabinowitz JL, Green NS, Scharff MD. How to zap a kappa. Current Biology : Cb. 2: 10-2. PMID 15336060 DOI: 10.1016/0960-9822(92)90401-U  1
1992 Diamond B, Katz JB, Paul E, Aranow C, Lustgarten D, Scharff MD. The role of somatic mutation in the pathogenic anti-DNA response. Annual Review of Immunology. 10: 731-57. PMID 1591002 DOI: 10.1146/annurev.iy.10.040192.003503  1
1992 Casadevall A, Mukherjee J, Devi SJ, Schneerson R, Robbins JB, Scharff MD. Antibodies elicited by a Cryptococcus neoformans-tetanus toxoid conjugate vaccine have the same specificity as those elicited in infection. The Journal of Infectious Diseases. 165: 1086-93. PMID 1583327 DOI: 10.1093/infdis/165.6.1086  1
1992 Spira G, Scharff MD. Identification of rare immunoglobulin switch variants using the ELISA spot assay. Journal of Immunological Methods. 148: 121-9. PMID 1564322 DOI: 10.1016/0022-1759(92)90165-P  1
1992 Casadevall A, Mukherjee J, Scharff MD. Monoclonal antibody based ELISAs for cryptococcal polysaccharide. Journal of Immunological Methods. 154: 27-35. PMID 1401941 DOI: 10.1016/0022-1759(92)90209-C  1
1992 Mukherjee J, Scharff MD, Casadevall A. Protective murine monoclonal antibodies to Cryptococcus neoformans. Infection and Immunity. 60: 4534-41. PMID 1398966  1
1992 Casadevall A, Freundlich LF, Marsh L, Scharff MD. Extensive allelic variation in Cryptococcus neoformans. Journal of Clinical Microbiology. 30: 1080-4. PMID 1349897  1
1991 Kobrin BJ, Buhl S, Shulman MJ, Scharff MD. A V region mutation in a phosphocholine-binding monoclonal antibody results in loss of antigen binding. Journal of Immunology (Baltimore, Md. : 1950). 146: 2017-20. PMID 2005389  1
1991 Shin SU, DePinho R, Zack DJ, Rudikoff S, Scharff MD. Instability of immunoglobulin genes in S107 cell line. Somatic Cell and Molecular Genetics. 17: 259-76. PMID 1904631 DOI: 10.1007/BF01232821  1
1991 Behar SM, Lustgarten DL, Corbet S, Scharff MD. Characterization of somatically mutated S107 VH11-encoded anti-DNA autoantibodies derived from autoimmune (NZB x NZW)F1 mice. The Journal of Experimental Medicine. 173: 731-41. PMID 1900082  1
1991 Pirofski L, Horwitz MS, Scharff MD, Factor SM. Murine adenovirus infection of SCID mice induces hepatic lesions that resemble human Reye syndrome. Proceedings of the National Academy of Sciences of the United States of America. 88: 4358-62. PMID 1852004  1
1991 Casadevall A, Scharff MD. The mouse antibody response to infection with Cryptococcus neoformans: VH and VL usage in polysaccharide binding antibodies. The Journal of Experimental Medicine. 174: 151-60. PMID 1676047  1
1991 French DL, Pollock RR, Aguila HL, Scharff MD. The molecular and biochemical characterization of mutant monoclonal antibodies with increased antigen binding. Journal of Immunology (Baltimore, Md. : 1950). 146: 2010-6. PMID 1672339  1
1990 Pollock RR, French DL, Metlay JP, Birshtein BK, Scharff MD. Intravascular metabolism of normal and mutant mouse immunoglobulin molecules. European Journal of Immunology. 20: 2021-7. PMID 2120072 DOI: 10.1002/eji.1830200921  1
1990 Pirofski L, Casadevall A, Rodriguez L, Zuckier LS, Scharff MD. Current state of the hybridoma technology. Journal of Clinical Immunology. 10: 5S-12S; discussion 1. PMID 2081790 DOI: 10.1007/BF00918686  1
1989 Chien NC, Roberts VA, Giusti AM, Scharff MD, Getzoff ED. Significant structural and functional change of an antigen-binding site by a distant amino acid substitution: proposal of a structural mechanism. Proceedings of the National Academy of Sciences of the United States of America. 86: 5532-6. PMID 2748602  1
1989 Zuckier LS, Rodriguez LD, Scharff MD. Immunologic and pharmacologic concepts of monoclonal antibodies. Seminars in Nuclear Medicine. 19: 166-86. PMID 2669128 DOI: 10.1016/S0001-2998(89)80012-1  1
1989 French DL, Laskov R, Scharff MD. The role of somatic hypermutation in the generation of antibody diversity. Science (New York, N.Y.). 244: 1152-7. PMID 2658060  1
1989 Behar SM, Chien NC, Corbet S, Diamond B, Getzoff ED, Lustgarten D, Roberts VA, Scharff MD, Shin SU. Impact of somatic mutation on the S107(T15) heavy-chain V region of antibodies reactive with self and nonself. Cold Spring Harbor Symposia On Quantitative Biology. 54: 921-31. PMID 2518013  1
1989 Behar SM, Corbet S, Diamond B, Scharff MD. The molecular origin of anti-DNA antibodies. International Reviews of Immunology. 5: 23-42. PMID 2491158 DOI: 10.3109/08830188909086988  1
1988 Pollock RR, French DL, Gefter ML, Scharff MD. Identification of mutant monoclonal antibodies with increased antigen binding. Proceedings of the National Academy of Sciences of the United States of America. 85: 2298-302. PMID 3267219 DOI: 10.1073/pnas.85.7.2298  1
1988 Behar SM, Scharff MD. Somatic diversification of the S107 (T15) VH11 germ-line gene that encodes the heavy-chain variable region of antibodies to double-stranded DNA in (NZB x NZW)F1 mice. Proceedings of the National Academy of Sciences of the United States of America. 85: 3970-4. PMID 3131767  1
1988 Behar SM, Fischer B, Diamond B, Scharff MD. Variable region gene utilization and environmental antigens in autoimmunity. Monographs in Allergy. 24: 297-306. PMID 3129650  1
1988 Spira G, Aguila HL, Scharff MD. T15 PC-binding monoclonal antibodies retain specificity when they switch from IgM to IgG. Journal of Immunology (Baltimore, Md. : 1950). 140: 2675-80. PMID 3128603  1
1988 Chien NC, Pollock RR, Desaymard C, Scharff MD. Point mutations cause the somatic diversification of IgM and IgG2a antiphosphorylcholine antibodies. The Journal of Experimental Medicine. 167: 954-73. PMID 3127529  1
1988 Behar SM, Scharff MD. Somatic diversification of anti-DNA antibodies Annals of the New York Academy of Sciences. 546: 188.  1
1987 Albright JF, Scharff MD. Generation and maintenance of hybridomas. Immunology Today. 8: 256-7. PMID 25344275 DOI: 10.1016/0167-5699(87)90179-4  1
1987 French D, Kelly T, Buhl S, Scharff MD. Somatic cell genetic analysis of myelomas and hybridomas. Methods in Enzymology. 151: 50-66. PMID 3431452  1
1987 Burchiel SW, Pollock RR, Covell DG, Fuller G, Scharff MD. Pharmacokinetic analysis of biosynthetically radiolabeled mouse monoclonal antibodies in normal rhesus monkeys. International Journal of Immunopharmacology. 9: 913-8. PMID 3429078 DOI: 10.1016/0192-0561(87)90007-5  1
1987 Scharff MD, Aguila HL, Behar SM, Chien NC, DePinho R, French DL, Pollock RR, Shin SU. Studies on the somatic instability of immunoglobulin genes in vivo and in cultured cells. Immunological Reviews. 96: 75-90. PMID 3298011  1
1987 Giusti AM, Chien NC, Zack DJ, Shin SU, Scharff MD. Somatic diversification of S107 from an antiphosphocholine to an anti-DNA autoantibody is due to a single base change in its heavy chain variable region. Proceedings of the National Academy of Sciences of the United States of America. 84: 2926-30. PMID 3106981 DOI: 10.1073/pnas.84.9.2926  1
1986 Agulla HL, Pollock RR, Spira G, Scharff MD. The production of more useful monoclonal antibodies 2. The use of somatic-cell genetic and recombinant-DNA technology to tailor-make monoclonal antibodies. Immunology Today. 7: 380-3. PMID 25291336 DOI: 10.1016/0167-5699(86)90031-9  1
1986 French D, Fischberg E, Buhl S, Scharff MD. The production of more useful monoclonal antibodies I. Modifications of the basic technology. Immunology Today. 7: 344-6. PMID 25291104 DOI: 10.1016/0167-5699(86)90142-8  1
1986 Scharff MD, DePinho RA, Behar S, Beychok C, Shin SU, French D. The role of monoclonal antibodies and the recombinant DNA technology in studying autoantibody production. Cellular Immunology. 99: 29-37. PMID 3093101 DOI: 10.1016/0008-8749(86)90212-1  1
1986 DePinho RA, Feldman LB, Scharff MD. Tailor-made monoclonal antibodies. Annals of Internal Medicine. 104: 225-33. PMID 3080934  1
1986 Chien N, Giusti AM, Zack D, French D, Shin SU, Diamond B, Scharff MD. Effect of somatic mutation on antibody affinity and specificity. The Mount Sinai Journal of Medicine, New York. 53: 181-6. PMID 2422550  1
1986 Scharff MD. Introduction Cellular Immunology. 99: 1.  1
1985 Teillaud JL, Diamond B, Pollock RR, Fajtova V, Scharff MD. Fc receptors on cultured myeloma and hybridoma cells. Journal of Immunology (Baltimore, Md. : 1950). 134: 1774-9. PMID 3155773  1
1985 Spira G, Pollock RR, Bargellesi A, Scharff MD. Monoclonal antibodies: a potentially powerful tool in the diagnosis and treatment of infectious diseases. European Journal of Clinical Microbiology. 4: 251-6. PMID 2410264 DOI: 10.1007/BF02013647  1
1984 Spira G, Bargellesi A, Teillaud JL, Scharff MD. The identification of monoclonal class switch variants by sib selection and an ELISA assay. Journal of Immunological Methods. 74: 307-15. PMID 6438240 DOI: 10.1016/0022-1759(84)90298-9  1
1984 Diamond B, Scharff MD. Somatic mutation of the T15 heavy chain gives rise to an antibody with autoantibody specificity. Proceedings of the National Academy of Sciences of the United States of America. 81: 5841-4. PMID 6435121  1
1984 Desaymard C, Giusti AM, Scharff MD. Rat anti-T15 monoclonal antibodies with specificity for VH- and VH-VL epitopes. Molecular Immunology. 21: 961-7. PMID 6209566 DOI: 10.1016/0161-5890(84)90154-8  1
1984 Pollock RR, Teillaud JL, Scharff MD. Monoclonal antibodies: a powerful tool for selecting and analyzing mutations in antigens and antibodies. Annual Review of Microbiology. 38: 389-417. PMID 6208844 DOI: 10.1146/annurev.mi.38.100184.002133  1
1984 Pollock RR, Metlay JP, Scharff MD. Serum half life or normal and mutant monoclonal murine antibodies Federation Proceedings. 43: no. 1550.  1
1983 Thammana P, Scharff MD. Immunoglobulin heavy chain class switch from IgM to IgG in a hybridoma. European Journal of Immunology. 13: 614-9. PMID 6884421 DOI: 10.1002/eji.1830130803  1
1983 Teillaud JL, Desaymard C, Giusti AM, Haseltine B, Pollock RR, Yelton DE, Zack DJ, Scharff MD. Monoclonal antibodies reveal the structural basis of antibody diversity. Science (New York, N.Y.). 222: 721-6. PMID 6356353  0.32
1982 Diamond B, Scharff MD. Monoclonal antibodies. Jama. 248: 3165-9. PMID 7143696 DOI: 10.1001/jama.1982.03330230065038  1
1982 Scharff MD. Somatic cell genetics of immunoglobulin production. Cellular Immunology. 66: 29-33. PMID 7044566  1
1982 Yelton DE, Scharff MD. Mutant monoclonal antibodies with alterations in biological functions. The Journal of Experimental Medicine. 156: 1131-48. PMID 6818317  1
1982 Rudikoff S, Giusti AM, Cook WD, Scharff MD. Single amino acid substitution altering antigen-binding specificity. Proceedings of the National Academy of Sciences of the United States of America. 79: 1979-83. PMID 6804947  1
1982 Cook WD, Rudikoff S, Giusti AM, Scharff MD. Somatic mutation in a cultured mouse myeloma cell affects antigen binding. Proceedings of the National Academy of Sciences of the United States of America. 79: 1240-4. PMID 6803237  1
1981 Zack DJ, Morrison SL, Cook WD, Dackowski W, Scharff MD. Somatically generated mouse myeloma variants synthesizing IgA half-molecules. The Journal of Experimental Medicine. 154: 1554-69. PMID 7299348  1
1981 Scharff MD, Roberts S. Present status and future prospects for the hybridoma technology. In Vitro. 17: 1072-7. PMID 6976303 DOI: 10.1007/BF02618605  1
1981 Yelton DE, Desaymard C, Scharff MD. Use of monoclonal anti-mouse immunoglobulin to detect mouse antibodies. Hybridoma. 1: 5-11. PMID 6821395  1
1981 Morrison SL, Scharff MD. Mutational events in mouse myeloma cells. Critical Reviews in Immunology. 3: 1-22. PMID 6807601  1
1981 Kwan SP, Max EE, Seidman JG, Leder P, Scharff MD. Two kappa immunoglobulin genes are expressed in the myeloma S107. Cell. 26: 57-66. PMID 6799208 DOI: 10.1016/0092-8674(81)90033-7  1
1981 Yelton DE, Scharff MD. Monoclonal antibodies: a powerful new tool in biology and medicine. Annual Review of Biochemistry. 50: 657-80. PMID 6791578 DOI: 10.1146/annurev.bi.50.070181.003301  1
1981 Kwan SP, Rudikoff S, Seidman JG, Leder P, Scharff MD. Nucleic acid and protein sequences of phosphocholine-binding light chains. The Journal of Experimental Medicine. 153: 1366-70. PMID 6788890 DOI: 10.1084/jem.153.5.1366  1
1981 Scharff MD, Roberts S, Thammana P. Hybridomas as a source of antibodies. Hospital Practice (Office Ed.). 16: 61-6. PMID 6786973  1
1981 Diamond BA, Yelton DE, Scharff MD. Monoclonal antibodies. A new technique for producing serologic reagents. The New England Journal of Medicine. 304: 1344-9. PMID 6783911 DOI: 10.1056/NEJM198105283042208  1
1981 Scharff MD, Roberts S, Thammana P. Monoclonal antibodies. The Journal of Infectious Diseases. 143: 346-51. PMID 6164738  1
1980 Cieplinski W, Scharff MD. Membrane-associated ribosomes in producing and nonproducing mouse myeloma cells. Journal of Cellular Physiology. 103: 447-53. PMID 7400226 DOI: 10.1002/jcp.1041030310  1
1980 Diamond B, Scharff MD. IgG1 and IgG2b share the Fc receptor on mouse macrophages. Journal of Immunology (Baltimore, Md. : 1950). 125: 631-3. PMID 7391572  1
1980 Yelton DE, Cook WD, Scharff MD. Somatic variants in mouse myeloma and hybridoma cell lines. Transplantation Proceedings. 12: 439-42. PMID 6784302  1
1980 Yelton DE, Scharff MD. Monoclonal antibodies. American Scientist. 68: 510-6. PMID 6775567  1
1980 Cook WD, Rudikoff S, Giusti AM, Zack DJ, Kelly T, Scharff MD. Antigen binding variants of the S107 mouse myeloma cell line. Progress in Clinical and Biological Research. 42: 217-30. PMID 6771769  1
1979 Diamond B, Birshtein BK, Scharff MD. Site of binding of mouse IgG2b to the Fc receptor on mouse macrophages. The Journal of Experimental Medicine. 150: 721-6. PMID 479765  1
1979 Newman W, Diamond B, Flomenberg P, Scharff MD, Bloom BR. Response of a continuous macrophage-like cell line to MIF. Journal of Immunology (Baltimore, Md. : 1950). 123: 2292-7. PMID 385779  1
1979 Morrison SL, Scharff MD. A mouse myeloma variant with a defect in light chain synthesis. European Journal of Immunology. 9: 461-5. PMID 115696 DOI: 10.1002/eji.1830090609  1
1979 Scharff MD. Cell hybrids in immunology Federation Proceedings. 38: 2442-2443.  1
1978 Diamond B, Bloom BR, Scharff MD. The Fc receptors of primary and cultured phagocytic cells studied with homogeneous antibodies. Journal of Immunology (Baltimore, Md. : 1950). 121: 1329-33. PMID 701797  1
1978 Yelton DE, Diamond BA, Kwan SP, Scharff MD. Fusion of mouse myeloma and spleen cells. Current Topics in Microbiology and Immunology. 81: 1-7. PMID 567551  1
1978 Hurley JN, Fu SM, Kunkel HG, McKenna G, Scharff MD. Lymphoblastoid cell lines from patients with chronic lymphocytic leukemia: identification of tumor origin by idiotypic analysis. Proceedings of the National Academy of Sciences of the United States of America. 75: 5706-10. PMID 82971  1
1978 Francus T, Dharmgrongartama B, Campbell R, Scharff MD, Birshtein BK. IgG2a-producing variants of an IgG2b-producing mouse myeloma cell line. The Journal of Experimental Medicine. 147: 1535-50. PMID 79633  0.6
1977 Gefter ML, Margulies DH, Scharff MD. A simple method for polyethylene glycol-promoted hybridization of mouse myeloma cells. Somatic Cell Genetics. 3: 231-6. PMID 605383 DOI: 10.1007/BF01551818  1
1977 Margulies DH, Cieplinski W, Dharmgrongartama B, Gefter ML, Morrison SL, Kelly T, Scharff MD. Regulation of immunoglobulin expression in mouse myeloma cells. Cold Spring Harbor Symposia On Quantitative Biology. 41: 781-91. PMID 408077  1
1977 Weitzman S, Nathenson SG, Scharff MD. Abnormalities in the glycosylation of immunoglobulin heavy chain and an h-2 transplantation antigen in a mouse myeloma mutant. Cell. 10: 679-87. PMID 405105 DOI: 10.1016/0092-8674(77)90101-5  1
1977 Cook WD, Scharff MD. Antigen-binding mutants of mouse myeloma cells. Proceedings of the National Academy of Sciences of the United States of America. 74: 5687-91. PMID 271995  1
1976 Rajan TV, Nathenson SG, Scharff MD. Regulatory variants for the expression of H-2 antigens. I. Isolation and characterization. Journal of the National Cancer Institute. 56: 1221-7. PMID 994223  1
1976 Margulies DH, Kuehl WM, Scharff MD. Somatic cell hybridization of mouse myeloma cells. Cell. 8: 405-15. PMID 821618 DOI: 10.1016/0092-8674(76)90153-7  1
1976 Weitzman S, Margulies DH, Scharff MD. Mutations in mouse myeloma cells: implications for human multiple myeloma and the production of immunoglobulins. Annals of Internal Medicine. 85: 110-6. PMID 820230  1
1976 Weitzman S, Scharff MD. Mouse myeloma mutants blocked in the assembly, glycosylation and secretion of immunoglobulin. Journal of Molecular Biology. 102: 237-52. PMID 818392 DOI: 10.1016/S0022-2836(76)80051-4  1
1976 Bargellesi A, Damiani G, Kuehl WM, Scharff MD. Synthesis of immunoglobulin by substrate attached mouse myeloma cells. Journal of Cellular Physiology. 88: 247-51. PMID 818094 DOI: 10.1002/jcp.1040880214  1
1976 Baumal R, Scharff MD. Immunoglobulin biosynthesis by the MOPC 173 mouse myeloma tumor and a variant spleen clone. Journal of Immunology (Baltimore, Md. : 1950). 116: 65-74. PMID 812916  1
1975 Kuehl WM, Kaplan BA, Scharff MD. Characterization of light chain and light chain constant region fragment mRNAs in MPC 11 mouse myeloma cells and variants. Cell. 5: 139-47. PMID 806346 DOI: 10.1016/0092-8674(75)90022-7  1
1975 Preud'Homme JL, Birshtein BK, Scharff MD. Variants of a mouse myeloma cell line that synthesize immunoglobulin heavy chains having an altered serotype. Proceedings of the National Academy of Sciences of the United States of America. 72: 1427-30. PMID 805428  1
1975 Morrison SL, Scharff MD. Heavy chain-producing variants of a mouse myeloma cell line. Journal of Immunology (Baltimore, Md. : 1950). 114: 655-9. PMID 804509  1
1974 Buxbaum JN, Zolla S, Scharff MD, Franklin EC. The synthesis and assembly of immunoglobulins by malignant human plasmacytes. 3. Heterogeneity in IgA polymer assembly. European Journal of Immunology. 4: 367-9. PMID 4855105 DOI: 10.1002/eji.1830040512  1
1974 Morrison SL, Baumal R, Birshtein BK, Kuehl UM, Preud'homme JL, Frank L, Jasek T, Scharff MD. The identification of mouse myeloma cells which have undergone mutations in immunoglobulin production. Society of General Physiologists Series. 29: 233-44. PMID 4215140  1
1974 Preud'homme JL, Scharff MD. The capping of surface immunoglobulin on mouse myeloma cells. Journal of Immunology (Baltimore, Md. : 1950). 113: 702-4. PMID 4210889  0.6
1974 Birshtein BK, Preud'homme JL, Scharff MD. Variants of mouse myeloma cells that produce short immunoglobulin heavy chains. Proceedings of the National Academy of Sciences of the United States of America. 71: 3478-82. PMID 4139712  0.6
1973 Baumal R, Scharff MD. Synthesis, assembly and secretion of mouse immunoglobulin. Transplantation Reviews. 14: 163-83. PMID 4728820  0.32
1973 Scharff MD, Baumal R, Coffino P, Birshtein B, Kuehl WM. The use of mouse and human cell lines in studying the regulation of immunoglobulin production. Birth Defects Original Article Series. 9: 73-89. PMID 4688449  1
1973 Baumal R, Birshtein BK, Coffino P, Scharff MD. Mutations in immunoglobulin-producing mouse myeloma cells. Science (New York, N.Y.). 182: 164-6. PMID 4354174  1
1973 Baumal R, Scharff MD. Synthesis, assembly and secretion of gamma-globulin by mouse myeloma cells. V. Balanced and unbalanced synthesis of heavy and light chains by IgG-producing tumors and cell lines. Journal of Immunology (Baltimore, Md. : 1950). 111: 448-56. PMID 4123978  0.32
1972 Coffino P, Baumal R, Laskov R, Scharff MD. Cloning of mouse myeloma cells and detection of rare variants. Journal of Cellular Physiology. 79: 429-40. PMID 4625122 DOI: 10.1002/jcp.1040790313  1
1971 Baumal R, Coffino P, Bargellesi A, Buxbaum J, Laskov R, Scharff MD. The regulation of immunoglobulin synthesis and assembly. Annals of the New York Academy of Sciences. 190: 235-49. PMID 5290017  1
1971 Coffino P, Scharff MD. Rate of somatic mutation in immunoglobulin production by mouse myeloma cells. Proceedings of the National Academy of Sciences of the United States of America. 68: 219-23. PMID 5276293  1
1971 Baumal R, Potter M, Scharff MD. Synthesis, assembly, and secretion of gamma globulin by mouse myeloma cells. 3. Assembly of the three subclasses of IgG. The Journal of Experimental Medicine. 134: 1316-34. PMID 5112205  0.32
1971 Baumal R, Bloom B, Scharff MD. Induction of long term lymphocyte lines from delayed hypersensitive human donors using specific antigen plus Epstein-Barr virus. Nature: New Biology. 230: 20-1. PMID 4326813  0.32
1971 Coffino P, Knowles B, Nathenson SG, Scharff MD. Suppression of immunoglobulin synthesis by cellular hybridization. Nature: New Biology. 231: 87-90. PMID 4103301  1
1970 Horwitz MS, Maizel JV, Scharff MD. Molecular weight of Adenovirus type 2 hexon polypeptide. Journal of Virology. 6: 569-71. PMID 5497905  0.4
1970 Darnell JE, Levintow L, Scharff MD. Harry Eagle. Journal of Cellular Physiology. 76: 241-52. PMID 4925975 DOI: 10.1002/jcp.1040760304  1
1970 Maizel JV, Summers DF, Scharff MD. SDS-acrylamide gel electrophoresis and its application to the proteins of poliovirus- and adenovirus-infected human cells. Journal of Cellular Physiology. 76: 273-87. PMID 4322980 DOI: 10.1002/jcp.1040760307  0.56
1970 Coffino P, Laskov R, Scharff MD. Immunoglobulin production: method for quantitatively detecting variant myeloma cells. Science (New York, N.Y.). 167: 186-8. PMID 4188146  1
1970 Scharff MD, Bargellesi A, Baumal R, Buxbaum J, Coffino P, Laskov R. Variations in the synthesis and assembly of immunoglobulins by mouse myeloma cells: a genetic and biochemical analysis. Journal of Cellular Physiology. 76: 331-48. PMID 4100579 DOI: 10.1002/jcp.1040760311  1
1969 Horwitz MS, Scharff MD, Maizel JV. Synthesis and assembly of adenovirus 2. I. Polypeptide synthesis, assembly of capsomeres, and morphogenesis of the virion. Virology. 39: 682-94. PMID 5358824  0.4
1969 White DO, Scharff MD, Maizel JV. The polypeptides of adenovirus. 3. Synthesis in infected cells. Virology. 38: 395-406. PMID 4240554  0.4
1968 Maizel JV, White DO, Scharff MD. The polypeptides of adenovirus. II. Soluble proteins, cores, top components and the structure of the virion. Virology. 36: 126-36. PMID 5669983  0.4
1968 Maizel JV, White DO, Scharff MD. The polypeptides of adenovirus. I. Evidence for multiple protein components in the virion and a comparison of types 2, 7A, and 12. Virology. 36: 115-25. PMID 5669982  0.4
1966 Shapiro AL, Scharff MD, Maizel JV, Uhr JW. Synthesis of excess light chains of gamma globulin by rabbit lymph node cells. Nature. 211: 243-5. PMID 5965538  0.4
1966 Shapiro AL, Scharff MD, Maizel JV, Uhr JW. Polyribosomal synthesis and assembly of the H and L chains of gamma globulin. Proceedings of the National Academy of Sciences of the United States of America. 56: 216-21. PMID 4165344  0.4
1965 Scharff MD, Summers DF, Levintow L. Further studies on the effect of p-fluorophenylalanine and puromycin on polio virus replication. Annals of the New York Academy of Sciences. 130: 282-90. PMID 4285576  1
1964 SCHARFF MD, MAIZEL JV, LEVINTOW L. PHYSICAL AND IMMUNOLOGICAL PROPERTIES OF A SOLUBLE PRECURSOR OF THE POLIOVIRUS CAPSID. Proceedings of the National Academy of Sciences of the United States of America. 51: 329-37. PMID 14124331  1
1963 SCHARFF MD, SHATKIN AJ, LEVINTOW L. ASSOCIATION OF NEWLY FORMED VIRAL PROTEIN WITH SPECIFIC POLYRIBOSOMES. Proceedings of the National Academy of Sciences of the United States of America. 50: 686-94. PMID 14077498  1
1963 SCHARFF MD, LEVINTOW L. Quantitative study of the formation of poliovirus antigens in infected HeLa cells. Virology. 19: 491-500. PMID 13976714  1
1963 SCHARFF MD, THOREN MM, McELVAIN NF, LEVINTOW L. Interruption of poliovirus RNA synthesis by p-fluorophenylalanine and puromycin. Biochemical and Biophysical Research Communications. 10: 127-32. PMID 13976712  1
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