Benjamin Turk - Publications

Affiliations: 
Yale University School of Medicine, New Haven, CT 

124 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Ghosh C, Uppala JK, Sathe L, Hammond CI, Anshu A, Pokkuluri PR, Turk BE, Dey M. Phosphorylation of Pal2 by the protein kinases Kin1 and Kin2 modulates mRNA splicing in the unfolded protein response in yeast. Science Signaling. 14. PMID 34035143 DOI: 10.1126/scisignal.aaz4401  1
2021 Yuan Q, Basit A, Liang W, Qu R, Luan Y, Ren C, Li A, Xu X, Liu X, Yang C, Kuo A, Pierce R, Zhang L, Turk B, Hu X, et al. Pazopanib ameliorates acute lung injuries via inhibition of MAP3K2 and MAP3K3. Science Translational Medicine. 13. PMID 33910977 DOI: 10.1126/scitranslmed.abc2499  1
2021 Cho E, Lou HJ, Kuruvilla L, Calderwood DA, Turk BE. PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK. Cell Reports. 34: 108928. PMID 33789117 DOI: 10.1016/j.celrep.2021.108928  1
2021 Torres-Ayuso P, An E, Nyswaner KM, Bensen RC, Ritt DA, Specht SI, Das S, Andresson T, Cachau RE, Liang RJ, Ries AL, Robinson CM, Difilippantonio S, Gouker B, Bassel L, ... ... Turk BE, et al. TNIK is a therapeutic target in Lung Squamous Cell Carcinoma and regulates FAK activation through Merlin. Cancer Discovery. PMID 33495197 DOI: 10.1158/2159-8290.CD-20-0797  1
2020 Komolov KE, Sulon SM, Bhardwaj A, van Keulen SC, Duc NM, Laurinavichyute DK, Lou HJ, Turk BE, Chung KY, Dror RO, Benovic JL. Structure of a GRK5-Calmodulin Complex Reveals Molecular Mechanism of GRK Activation and Substrate Targeting. Molecular Cell. PMID 33321095 DOI: 10.1016/j.molcel.2020.11.026  1
2020 Zhou M, Kuruvilla L, Shi X, Viviano S, Ahearn IM, Amendola CR, Su W, Badri S, Mahaffey J, Fehrenbacher N, Skok J, Schlessinger J, Turk BE, Calderwood DA, Philips MR. Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association. Proceedings of the National Academy of Sciences of the United States of America. PMID 33257571 DOI: 10.1073/pnas.2005712117  1
2020 Terekhov SS, Mokrushina YA, Nazarov AS, Zlobin A, Zalevsky A, Bourenkov G, Golovin A, Belogurov A, Osterman IA, Kulikova AA, Mitkevich VA, Lou HJ, Turk BE, Wilmanns M, Smirnov IV, et al. A kinase bioscavenger provides antibiotic resistance by extremely tight substrate binding. Science Advances. 6: eaaz9861. PMID 32637600 DOI: 10.1126/Sciadv.Aaz9861  1
2020 Chetty AK, Sexton JA, Hak Ha B, Turk BE, Boggon TJ. Recognition of physiological phosphorylation sites by p21-activated kinase 4. Journal of Structural Biology. 107553. PMID 32585314 DOI: 10.1016/j.jsb.2020.107553  1
2019 Sang D, Pinglay S, Wiewiora RP, Selvan ME, Lou HJ, Chodera JD, Turk BE, Gümüş ZH, Holt LJ. Ancestral reconstruction reveals mechanisms of ERK regulatory evolution. Elife. 8. PMID 31407663 DOI: 10.7554/Elife.38805  1
2019 Santini CC, Longden J, Schoof EM, Simpson CD, Jeschke GR, Creixell P, Kim J, Wu X, Turk BE, Rosen N, Poulikakos PI, Linding R. Global view of the RAF-MEK-ERK module and its immediate downstream effectors. Scientific Reports. 9: 10865. PMID 31350469 DOI: 10.1038/S41598-019-47245-X  1
2019 van de Kooij B, Creixell P, van Vlimmeren A, Joughin B, Miller CJ, Haider N, Simpson CD, Linding R, Stambolic V, Turk BE, Yaffe MB. Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs. Elife. 8. PMID 31124786 DOI: 10.7554/Elife.44635  1
2019 Miller CJ, Lou HJ, Simpson C, van de Kooij B, Ha BH, Fisher OS, Pirman NL, Boggon TJ, Rinehart J, Yaffe MB, Linding R, Turk BE. Comprehensive profiling of the STE20 kinase family defines features essential for selective substrate targeting and signaling output. Plos Biology. 17: e2006540. PMID 30897078 DOI: 10.1371/Journal.Pbio.2006540  1
2018 Waldt N, Seifert A, Demiray YE, Devroe E, Turk BE, Reichardt P, Mix C, Reinhold A, Freund C, Müller AJ, Schraven B, Stork O, Kliche S. Filamin A Phosphorylation at Serine 2152 by the Serine/Threonine Kinase Ndr2 Controls TCR-Induced LFA-1 Activation in T Cells. Frontiers in Immunology. 9: 2852. PMID 30568657 DOI: 10.3389/Fimmu.2018.02852  0.01
2018 Govindasamy K, Khan R, Snyder M, Lou HJ, Du P, Kudyba HM, Muralidharan V, Turk BE, Bhanot P. falciparum cGMP-dependent protein kinase interacts with a subunit of the parasite proteasome. Infection and Immunity. PMID 30323024 DOI: 10.1128/IAI.00523-18  1
2018 Jeschke GR, Lou HJ, Weise K, Hammond CI, Demonch M, Brennwald P, Turk BE. Substrate priming enhances phosphorylation by the budding yeast kinases Kin1 and Kin2. The Journal of Biological Chemistry. PMID 30305396 DOI: 10.1074/jbc.RA118.005651  1
2018 Turk BE. Exceptionally Selective Substrate Targeting by the Metalloprotease Anthrax Lethal Factor. Advances in Experimental Medicine and Biology. PMID 30267305 DOI: 10.1007/5584_2018_273  0.01
2018 Barber KW, Miller CJ, Jun JW, Lou HJ, Turk BE, Rinehart J. Kinase Substrate Profiling Using a Proteome-wide Serine-Oriented Human Peptide Library. Biochemistry. PMID 29920078 DOI: 10.1021/Acs.Biochem.8B00410  1
2018 Miller CJ, Turk BE. Homing in: Mechanisms of Substrate Targeting by Protein Kinases. Trends in Biochemical Sciences. PMID 29544874 DOI: 10.1016/j.tibs.2018.02.009  1
2018 Marholz LJ, Zeringo NA, Lou HJ, Turk BE, Parker LL. In Silico Design and in Vitro Characterization of Universal Tyrosine Kinase Peptide Substrates. Biochemistry. PMID 29528224 DOI: 10.1021/Acs.Biochem.8B00044  1
2018 Hara M, Lourido S, Petrova B, Lou HJ, Von Stetina JR, Kashevsky H, Turk BE, Orr-Weaver TL. Identification of PNG kinase substrates uncovers interactions with the translational repressor TRAL in the oocyte-to-embryo transition. Elife. 7. PMID 29480805 DOI: 10.7554/Elife.33150  1
2018 Turk BE. Glycogen synthase kinase-3β regulation: another kinase gets in on the AKT. Febs Letters. PMID 29417553 DOI: 10.1002/1873-3468.12995  0.01
2017 Escobar GJ, Baker JM, Turk BJ, Draper D, Liu V, Kipnis P. Comparing Hospital Processes and Outcomes in California Medicare Beneficiaries: Simulation Prompts Reconsideration. The Permanente Journal. 21. PMID 29035176 DOI: 10.7812/TPP/16-084  0.01
2017 Advani G, Lim YC, Catimel B, Lio DSS, Ng NLY, Chüeh AC, Tran M, Anasir MI, Verkade H, Zhu HJ, Turk BE, Smithgall TE, Ang CS, Griffin M, Cheng HC. Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine. Cell Communication and Signaling : Ccs. 15: 29. PMID 28784162 DOI: 10.1186/S12964-017-0186-X  1
2017 Miller CJ, Muftuoglu Y, Turk BE. A high throughput assay to identify substrate-selective inhibitors of the ERK protein kinases. Biochemical Pharmacology. PMID 28647489 DOI: 10.1016/j.bcp.2017.06.127  1
2017 Cobbaut M, Derua R, Döppler H, Lou HJ, Vandoninck S, Storz P, Turk BE, Seufferlein T, Waelkens E, Janssens V, Van Lint J. Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop. Scientific Reports. 7: 887. PMID 28428613 DOI: 10.1038/S41598-017-00800-W  1
2017 Chen C, Nimlamool W, Miller CJ, Lou HJ, Turk BE. Rational redesign of a functional protein kinase-substrate interaction. Acs Chemical Biology. PMID 28314095 DOI: 10.1021/acschembio.7b00089  1
2017 Tio CW, Omerza G, Phillips T, Lou HJ, Turk BE, Winter E. Ssp2 binding activates the Smk1 MAPK. Molecular and Cellular Biology. PMID 28223369 DOI: 10.1128/Mcb.00607-16  1
2016 Goldberg AB, Cho E, Miller CJ, Lou HJ, Turk BE. Identification of a substrate-selective exosite within the metalloproteinase anthrax lethal factor. The Journal of Biological Chemistry. PMID 27909054 DOI: 10.1074/jbc.M116.761734  1
2016 Escobar GJ, Turk BJ, Ragins A, Ha J, Hoberman B, LeVine SM, Ballesca MA, Liu V, Kipnis P. Piloting electronic medical record-based early detection of inpatient deterioration in community hospitals. Journal of Hospital Medicine. 11: S18-S24. PMID 27805795 DOI: 10.1002/jhm.2652  0.01
2016 Kipnis P, Turk BJ, Wulf DA, Carlos LaGuardia J, XLiu V, Churpek MM, Romero-Brufau S, Escobar GJ. DEVELOPMENT AND VALIDATION OF AN ELECTRONIC MEDICAL RECORD-BASED ALERT SCORE FOR DETECTION OF INPATIENT DETERIORATION OUTSIDE THE ICU. Journal of Biomedical Informatics. PMID 27658885 DOI: 10.1016/j.jbi.2016.09.013  0.01
2016 Shi X, Mihaylova VT, Kuruvilla L, Chen F, Viviano S, Baldassarre M, Sperandio D, Martinez R, Yue P, Bates JG, Breckenridge DG, Schlessinger J, Turk BE, Calderwood DA. Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-β-dependent mechanisms. Proceedings of the National Academy of Sciences of the United States of America. PMID 27432991 DOI: 10.1073/Pnas.1608319113  1
2016 Hamill S, Lou HJ, Turk BE, Boggon TJ. Structural Basis for Noncanonical Substrate Recognition of Cofilin/ADF Proteins by LIM Kinases. Molecular Cell. 62: 397-408. PMID 27153537 DOI: 10.1016/j.molcel.2016.04.001  1
2016 Zhang YW, Turk BE, Rudnick G. Control of serotonin transporter phosphorylation by conformational state. Proceedings of the National Academy of Sciences of the United States of America. PMID 27140629 DOI: 10.1073/Pnas.1603282113  1
2016 Goldberg AB, Turk BE. Inhibitors of the Metalloproteinase Anthrax Lethal Factor. Current Topics in Medicinal Chemistry. PMID 27072692  1
2016 Mathea S, Abdul Azeez KR, Salah E, Tallant C, Wolfreys F, Konietzny R, Fischer R, Lou HJ, Brennan PE, Schnapp G, Pautsch A, Kessler BM, Turk BE, Knapp S. Structure of the Human Protein Kinase ZAK in Complex with Vemurafenib. Acs Chemical Biology. PMID 26999302 DOI: 10.1021/Acschembio.6B00043  1
2016 Miller CJ, Turk BE. Rapid Identification of Protein Kinase Phosphorylation Site Motifs Using Combinatorial Peptide Libraries. Methods in Molecular Biology (Clifton, N.J.). 1360: 203-16. PMID 26501912 DOI: 10.1007/978-1-4939-3073-9_15  1
2016 Deng Y, Turk BE. Analysis of Protein Tyrosine Kinase Specificity Using Positional Scanning Peptide Microarrays. Methods in Molecular Biology (Clifton, N.J.). 1352: 27-34. PMID 26490465 DOI: 10.1007/978-1-4939-3037-1_3  1
2015 Liu V, Herbert D, Foss-Durant A, Marelich GP, Patel A, Whippy A, Turk BJ, Ragins AI, Kipnis P, Escobar GJ. Evaluation Following Staggered Implementation of the "Rethinking Critical Care" ICU Care Bundle in a Multicenter Community Setting. Critical Care Medicine. PMID 26540402 DOI: 10.1097/CCM.0000000000001462  1
2015 Agarwal D, Qi Y, Jiang T, Liu X, Shi W, Wali VB, Turk B, Ross JS, Fraser Symmans W, Pusztai L, Hatzis C. Characterization of DNA variants in the human kinome in breast cancer. Scientific Reports. 5: 14736. PMID 26420498 DOI: 10.1038/Srep14736  1
2015 Creixell P, Palmeri A, Miller CJ, Lou HJ, Santini CC, Nielsen M, Turk BE, Linding R. Unmasking Determinants of Specificity in the Human Kinome. Cell. 163: 187-201. PMID 26388442 DOI: 10.1016/J.Cell.2015.08.057  1
2015 Creixell P, Schoof EM, Simpson CD, Longden J, Miller CJ, Lou HJ, Perryman L, Cox TR, Zivanovic N, Palmeri A, Wesolowska-Andersen A, Helmer-Citterich M, Ferkinghoff-Borg J, Itamochi H, Bodenmiller B, ... ... Turk BE, et al. Kinome-wide Decoding of Network-Attacking Mutations Rewiring Cancer Signaling. Cell. 163: 202-17. PMID 26388441 DOI: 10.1016/J.Cell.2015.08.056  1
2015 Ronkina N, Johansen C, Bohlmann L, Lafera J, Menon MB, Tiedje C, Laaß K, Turk BE, Iversen L, Kotlyarov A, Gaestel M. Comparative Analysis of Two Gene-Targeting Approaches Challenges the Tumor-Suppressive Role of the Protein Kinase MK5/PRAK. Plos One. 10: e0136138. PMID 26295581 DOI: 10.1371/journal.pone.0136138  1
2015 Fisher OS, Deng H, Liu D, Zhang Y, Wei R, Deng Y, Zhang F, Louvi A, Turk BE, Boggon TJ, Su B. Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex. Nature Communications. 6: 7937. PMID 26235885 DOI: 10.1038/ncomms8937  1
2015 Egan DF, Chun MG, Vamos M, Zou H, Rong J, Miller CJ, Lou HJ, Raveendra-Panickar D, Yang CC, Sheffler DJ, Teriete P, Asara JM, Turk BE, Cosford ND, Shaw RJ. Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates. Molecular Cell. PMID 26118643 DOI: 10.1016/J.Molcel.2015.05.031  1
2015 Osman K, Lou HJ, Qiu W, Brand V, Edwards AM, Turk BE, Hui R. Biochemical characterization of FIKK8-a unique protein kinase from the malaria parasite Plasmodium falciparum and other apicomplexans. Molecular and Biochemical Parasitology. PMID 26112892 DOI: 10.1016/j.molbiopara.2015.06.002  1
2015 Ha BH, Morse EM, Turk BE, Boggon TJ. Signaling, regulation, and specificity of the type II p21-activated kinases Journal of Biological Chemistry. 290: 12975-12983. PMID 25855792 DOI: 10.1074/jbc.R115.650416  1
2014 Howard CJ, Hanson-Smith V, Kennedy KJ, Miller CJ, Lou HJ, Johnson AD, Turk BE, Holt LJ. Ancestral resurrection reveals evolutionary mechanisms of kinase plasticity. Elife. 3. PMID 25310241 DOI: 10.7554/Elife.04126  1
2014 Deng Y, Alicea-Velázquez NL, Bannwarth L, Lehtonen SI, Boggon TJ, Cheng HC, Hytönen VP, Turk BE. Global analysis of human nonreceptor tyrosine kinase specificity using high-density peptide microarrays. Journal of Proteome Research. 13: 4339-46. PMID 25164267 DOI: 10.1021/pr500503q  1
2014 Chen CD, Tung TY, Liang J, Zeldich E, Tucker Zhou TB, Turk BE, Abraham CR. Identification of cleavage sites leading to the shed form of the anti-aging protein klotho. Biochemistry. 53: 5579-87. PMID 25110992 DOI: 10.1021/Bi500409N  1
2014 Goodwin JM, Svensson RU, Lou HJ, Winslow MM, Turk BE, Shaw RJ. An AMPK-independent signaling pathway downstream of the LKB1 tumor suppressor controls Snail1 and metastatic potential. Molecular Cell. 55: 436-50. PMID 25042806 DOI: 10.1016/J.Molcel.2014.06.021  1
2014 Galan JA, Geraghty KM, Lavoie G, Kanshin E, Tcherkezian J, Calabrese V, Jeschke GR, Turk BE, Ballif BA, Blenis J, Thibault P, Roux PP. Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3. Proceedings of the National Academy of Sciences of the United States of America. 111: E2918-27. PMID 25002506 DOI: 10.1073/Pnas.1405601111  1
2014 Etheridge RD, Alaganan A, Tang K, Lou HJ, Turk BE, Sibley LD. The Toxoplasma pseudokinase ROP5 forms complexes with ROP18 and ROP17 kinases that synergize to control acute virulence in mice. Cell Host & Microbe. 15: 537-50. PMID 24832449 DOI: 10.1016/J.Chom.2014.04.002  1
2014 Maiolica A, de Medina-Redondo M, Schoof EM, Chaikuad A, Villa F, Gatti M, Jeganathan S, Lou HJ, Novy K, Hauri S, Toprak UH, Herzog F, Meraldi P, Penengo L, Turk BE, et al. Modulation of the chromatin phosphoproteome by the Haspin protein kinase. Molecular & Cellular Proteomics : McP. 13: 1724-40. PMID 24732914 DOI: 10.1074/Mcp.M113.034819  1
2014 Ballesca MA, LaGuardia JC, Lee PC, Hwang AM, Park DK, Gardner MN, Turk BJ, Kipnis P, Escobar GJ. An electronic order set for acute myocardial infarction is associated with improved patient outcomes through better adherence to clinical practice guidelines. Journal of Hospital Medicine. 9: 155-61. PMID 24493376 DOI: 10.1002/jhm.2149  1
2014 Papinski D, Schuschnig M, Reiter W, Wilhelm L, Barnes CA, Maiolica A, Hansmann I, Pfaffenwimmer T, Kijanska M, Stoffel I, Lee SS, Brezovich A, Lou JH, Turk BE, Aebersold R, et al. Early steps in autophagy depend on direct phosphorylation of Atg9 by the Atg1 kinase. Molecular Cell. 53: 471-83. PMID 24440502 DOI: 10.1016/J.Molcel.2013.12.011  1
2014 Chen C, Ha BH, Thévenin AF, Lou HJ, Zhang R, Yip KY, Peterson JR, Gerstein M, Kim PM, Filippakopoulos P, Knapp S, Boggon TJ, Turk BE. Identification of a major determinant for serine-threonine kinase phosphoacceptor specificity. Molecular Cell. 53: 140-7. PMID 24374310 DOI: 10.1016/J.Molcel.2013.11.013  1
2014 Escobar GJ, Puopolo KM, Wi S, Turk BJ, Kuzniewicz MW, Walsh EM, Newman TB, Zupancic J, Lieberman E, Draper D. Stratification of risk of early-onset sepsis in newborns ≥ 34 weeks' gestation. Pediatrics. 133: 30-6. PMID 24366992 DOI: 10.1542/peds.2013-1689  1
2013 Gao J, Ha BH, Lou HJ, Morse EM, Zhang R, Calderwood DA, Turk BE, Boggon TJ. Substrate and inhibitor specificity of the type II p21-activated kinase, PAK6. Plos One. 8: e77818. PMID 24204982 DOI: 10.1371/Journal.Pone.0077818  1
2013 Liu V, Clark MP, Mendoza M, Saket R, Gardner MN, Turk BJ, Escobar GJ. Automated identification of pneumonia in chest radiograph reports in critically ill patients. Bmc Medical Informatics and Decision Making. 13: 90. PMID 23947340 DOI: 10.1186/1472-6947-13-90  1
2013 Kang SA, Pacold ME, Cervantes CL, Lim D, Lou HJ, Ottina K, Gray NS, Turk BE, Yaffe MB, Sabatini DM. mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin. Science (New York, N.Y.). 341: 1236566. PMID 23888043 DOI: 10.1126/Science.1236566  1
2013 Morell M, Nguyen Duc T, Willis AL, Syed S, Lee J, Deu E, Deng Y, Xiao J, Turk BE, Jessen JR, Weiss SJ, Bogyo M. Coupling protein engineering with probe design to inhibit and image matrix metalloproteinases with controlled specificity. Journal of the American Chemical Society. 135: 9139-48. PMID 23701445 DOI: 10.1021/Ja403523P  1
2013 Newman RH, Hu J, Rho HS, Xie Z, Woodard C, Neiswinger J, Cooper C, Shirley M, Clark HM, Hu S, Hwang W, Jeong JS, Wu G, Lin J, Gao X, ... ... Turk BE, et al. Construction of human activity-based phosphorylation networks. Molecular Systems Biology. 9: 655. PMID 23549483 DOI: 10.1038/Msb.2013.12  1
2013 Lourido S, Jeschke GR, Turk BE, Sibley LD. Exploiting the unique ATP-binding pocket of toxoplasma calcium-dependent protein kinase 1 to identify its substrates. Acs Chemical Biology. 8: 1155-62. PMID 23530747 DOI: 10.1021/Cb400115Y  1
2013 Liu V, Turk BJ, Ragins AI, Kipnis P, Escobar GJ. An electronic Simplified Acute Physiology Score-based risk adjustment score for critical illness in an integrated healthcare system. Critical Care Medicine. 41: 41-8. PMID 23222263 DOI: 10.1097/CCM.0b013e318267636e  1
2012 Deng Y, Couch BA, Koleske AJ, Turk BE. A peptide photoaffinity probe specific for the active conformation of the Abl tyrosine kinase. Chembiochem : a European Journal of Chemical Biology. 13: 2510-2. PMID 23081945 DOI: 10.1002/Cbic.201200560  1
2012 Lee YJ, Jeschke GR, Roelants FM, Thorner J, Turk BE. Reciprocal phosphorylation of yeast glycerol-3-phosphate dehydrogenases in adaptation to distinct types of stress. Molecular and Cellular Biology. 32: 4705-17. PMID 22988299 DOI: 10.1128/MCB.00897-12  1
2012 Ha BH, Davis MJ, Chen C, Lou HJ, Gao J, Zhang R, Krauthammer M, Halaban R, Schlessinger J, Turk BE, Boggon TJ. Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate. Proceedings of the National Academy of Sciences of the United States of America. 109: 16107-12. PMID 22988085 DOI: 10.1073/Pnas.1214447109  1
2012 Wong A, Zhang YW, Jeschke GR, Turk BE, Rudnick G. Cyclic GMP-dependent stimulation of serotonin transport does not involve direct transporter phosphorylation by cGMP-dependent protein kinase. The Journal of Biological Chemistry. 287: 36051-8. PMID 22942288 DOI: 10.1074/Jbc.M112.394726  1
2012 Bannwarth L, Goldberg AB, Chen C, Turk BE. Identification of exosite-targeting inhibitors of anthrax lethal factor by high-throughput screening. Chemistry & Biology. 19: 875-82. PMID 22840775 DOI: 10.1016/j.chembiol.2012.05.013  1
2012 Shehata SN, Hunter RW, Ohta E, Peggie MW, Lou HJ, Sicheri F, Zeqiraj E, Turk BE, Sakamoto K. Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase Cellular Signalling. 24: 2085-2094. PMID 22796189 DOI: 10.1016/j.cellsig.2012.06.018  1
2012 Escobar GJ, LaGuardia JC, Turk BJ, Ragins A, Kipnis P, Draper D. Early detection of impending physiologic deterioration among patients who are not in intensive care: development of predictive models using data from an automated electronic medical record. Journal of Hospital Medicine. 7: 388-95. PMID 22447632 DOI: 10.1002/jhm.1929  1
2012 Liu V, Turk BJ, Rizk NW, Kipnis P, Escobar GJ. The association between sepsis and potential medical injury among hospitalized patients. Chest. 142: 606-13. PMID 22383667 DOI: 10.1378/chest.11-2556  1
2012 Strochlic TI, Concilio S, Viaud J, Eberwine RA, Wong LE, Minden A, Turk BE, Plomann M, Peterson JR. Identification of neuronal substrates implicates Pak5 in synaptic vesicle trafficking. Proceedings of the National Academy of Sciences of the United States of America. 109: 4116-21. PMID 22371566 DOI: 10.1073/Pnas.1116560109  1
2012 Abramczyk O, Tavares CDJ, Devkota AK, Ryazanov AG, Turk BE, Riggs AF, Ozpolat B, Dalby KN. Corrigendum to "Purification and characterization of tagless recombinant human elongation factor 2 kinase (eEF-2K) expressed in Escherichia coli" [Protein Expression and Purification 79 (2011) 237-244] (DOI:10.1016/j.pep.2011.05.005) Protein Expression and Purification. DOI: 10.1016/J.Pep.2012.07.010  1
2011 Yip KY, Utz L, Sitwell S, Hu X, Sidhu SS, Turk BE, Gerstein M, Kim PM. Identification of specificity determining residues in peptide recognition domains using an information theoretic approach applied to large-scale binding maps. Bmc Biology. 9: 53. PMID 21835011 DOI: 10.1186/1741-7007-9-53  1
2011 Ia KK, Jeschke GR, Deng Y, Kamaruddin MA, Williamson NA, Scanlon DB, Culvenor JG, Hossain MI, Purcell AW, Liu S, Zhu HJ, Catimel B, Turk BE, Cheng HC. Defining the substrate specificity determinants recognized by the active site of C-terminal Src kinase-homologous kinase (CHK) and identification of β-synuclein as a potential CHK physiological substrate. Biochemistry. 50: 6667-77. PMID 21699177 DOI: 10.1021/bi2001938  1
2011 Abramczyk O, Tavares CD, Devkota AK, Ryazanov AG, Turk BE, Riggs AF, Ozpolat B, Dalby KN. Purification and characterization of tagless recombinant human elongation factor 2 kinase (eEF-2K) expressed in Escherichia coli. Protein Expression and Purification. 79: 237-44. PMID 21605678 DOI: 10.1016/J.Pep.2011.05.005  1
2010 Fentress SJ, Behnke MS, Dunay IR, Mashayekhi M, Rommereim LM, Fox BA, Bzik DJ, Taylor GA, Turk BE, Lichti CF, Townsend RR, Qiu W, Hui R, Beatty WL, Sibley LD. Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence. Cell Host & Microbe. 8: 484-95. PMID 21147463 DOI: 10.1016/J.Chom.2010.11.005  1
2010 Sirichandra C, Davanture M, Turk BE, Zivy M, Valot B, Leung J, Merlot S. The Arabidopsis ABA-activated kinase OST1 phosphorylates the bZIP transcription factor ABF3 and creates a 14-3-3 binding site involved in its turnover. Plos One. 5: e13935. PMID 21085673 DOI: 10.1371/journal.pone.0013935  0.01
2010 Kikani CK, Antonysamy SA, Bonanno JB, Romero R, Zhang FF, Russell M, Gheyi T, Iizuka M, Emtage S, Sauder JM, Turk BE, Burley SK, Rutter J. Structural bases of PAS domain-regulated kinase (PASK) activation in the absence of activation loop phosphorylation. The Journal of Biological Chemistry. 285: 41034-43. PMID 20943661 DOI: 10.1074/Jbc.M110.157594  1
2010 Chen C, Turk BE. Analysis of serine-threonine kinase specificity using arrayed positional scanning peptide libraries. Current Protocols in Molecular Biology. Unit 18.14. PMID 20583094 DOI: 10.1002/0471142727.mb1814s91  1
2010 Leissring MA, Malito E, Hedouin S, Reinstatler L, Sahara T, Abdul-Hay SO, Choudhry S, Maharvi GM, Fauq AH, Huzarska M, May PS, Choi S, Logan TP, Turk BE, Cantley LC, et al. Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin. Plos One. 5: e10504. PMID 20498699 DOI: 10.1371/Journal.Pone.0010504  1
2010 Lam HY, Kim PM, Mok J, Tonikian R, Sidhu SS, Turk BE, Snyder M, Gerstein MB. MOTIPS: automated motif analysis for predicting targets of modular protein domains. Bmc Bioinformatics. 11: 243. PMID 20459839 DOI: 10.1186/1471-2105-11-243  1
2010 Mok J, Kim PM, Lam HY, Piccirillo S, Zhou X, Jeschke GR, Sheridan DL, Parker SA, Desai V, Jwa M, Cameroni E, Niu H, Good M, Remenyi A, Ma JL, ... ... Turk BE, et al. Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs. Science Signaling. 3: ra12. PMID 20159853 DOI: 10.1126/Scisignal.2000482  1
2009 Caescu CI, Jeschke GR, Turk BE. Active-site determinants of substrate recognition by the metalloproteinases TACE and ADAM10. The Biochemical Journal. 424: 79-88. PMID 19715556 DOI: 10.1042/BJ20090549  1
2009 Davis TL, Walker JR, Allali-Hassani A, Parker SA, Turk BE, Dhe-Paganon S. Structural recognition of an optimized substrate for the ephrin family of receptor tyrosine kinases. The Febs Journal. 276: 4395-404. PMID 19678838 DOI: 10.1111/j.1742-4658.2009.07147.x  1
2009 Turk BE. Mixture-based peptide libraries for identifying protease cleavage motifs. Methods in Molecular Biology (Clifton, N.J.). 539: 79-91. PMID 19377969 DOI: 10.1007/978-1-60327-003-8_5  0.01
2009 Bullock AN, Das S, Debreczeni JE, Rellos P, Fedorov O, Niesen FH, Guo K, Papagrigoriou E, Amos AL, Cho S, Turk BE, Ghosh G, Knapp S. Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation. Structure (London, England : 1993). 17: 352-62. PMID 19278650 DOI: 10.1016/J.Str.2008.12.023  1
2009 Huang X, Finerty P, Walker JR, Butler-Cole C, Vedadi M, Schapira M, Parker SA, Turk BE, Thompson DA, Dhe-Paganon S. Structural insights into the inhibited states of the Mer receptor tyrosine kinase. Journal of Structural Biology. 165: 88-96. PMID 19028587 DOI: 10.1016/j.jsb.2008.10.003  1
2008 Filippakopoulos P, Kofler M, Hantschel O, Gish GD, Grebien F, Salah E, Neudecker P, Kay LE, Turk BE, Superti-Furga G, Pawson T, Knapp S. Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation. Cell. 134: 793-803. PMID 18775312 DOI: 10.1016/J.Cell.2008.07.047  1
2008 Miller ML, Jensen LJ, Diella F, Jørgensen C, Tinti M, Li L, Hsiung M, Parker SA, Bordeaux J, Sicheritz-Ponten T, Olhovsky M, Pasculescu A, Alexander J, Knapp S, Blom N, ... ... Turk BE, et al. Linear motif atlas for phosphorylation-dependent signaling. Science Signaling. 1: ra2. PMID 18765831 DOI: 10.1126/Scisignal.1159433  1
2008 Sheridan DL, Kong Y, Parker SA, Dalby KN, Turk BE. Substrate discrimination among mitogen-activated protein kinases through distinct docking sequence motifs. The Journal of Biological Chemistry. 283: 19511-20. PMID 18482985 DOI: 10.1074/Jbc.M801074200  1
2008 Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, Turk BE, Shaw RJ. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Molecular Cell. 30: 214-26. PMID 18439900 DOI: 10.1016/J.Molcel.2008.03.003  1
2008 Vlad F, Turk BE, Peynot P, Leung J, Merlot S. A versatile strategy to define the phosphorylation preferences of plant protein kinases and screen for putative substrates. The Plant Journal : For Cell and Molecular Biology. 55: 104-17. PMID 18363786 DOI: 10.1111/j.1365-313X.2008.03488.x  0.01
2008 Turk BE. Discovery and development of anthrax lethal factor metalloproteinase inhibitors. Current Pharmaceutical Biotechnology. 9: 24-33. PMID 18289054  0.01
2008 Turk BE. Understanding and exploiting substrate recognition by protein kinases. Current Opinion in Chemical Biology. 12: 4-10. PMID 18282484 DOI: 10.1016/j.cbpa.2008.01.018  0.01
2008 Pike AC, Rellos P, Niesen FH, Turnbull A, Oliver AW, Parker SA, Turk BE, Pearl LH, Knapp S. Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites. The Embo Journal. 27: 704-14. PMID 18239682 DOI: 10.1038/emboj.2008.8  1
2008 Eswaran J, Bernad A, Ligos JM, Guinea B, Debreczeni JE, Sobott F, Parker SA, Najmanovich R, Turk BE, Knapp S. Structure of the human protein kinase MPSK1 reveals an atypical activation loop architecture. Structure (London, England : 1993). 16: 115-24. PMID 18184589 DOI: 10.1016/J.Str.2007.10.026  1
2007 Bunkoczi G, Salah E, Filippakopoulos P, Fedorov O, Müller S, Sobott F, Parker SA, Zhang H, Min W, Turk BE, Knapp S. Structural and functional characterization of the human protein kinase ASK1. Structure (London, England : 1993). 15: 1215-26. PMID 17937911 DOI: 10.1016/j.str.2007.08.011  1
2007 Hutti JE, Turk BE, Asara JM, Ma A, Cantley LC, Abbott DW. IκB kinase β phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-κB pathway Molecular and Cellular Biology. 27: 7451-7461. PMID 17709380 DOI: 10.1128/Mcb.01101-07  1
2007 Rennefahrt UE, Deacon SW, Parker SA, Devarajan K, Beeser A, Chernoff J, Knapp S, Turk BE, Peterson JR. Specificity profiling of Pak kinases allows identification of novel phosphorylation sites. The Journal of Biological Chemistry. 282: 15667-78. PMID 17392278 DOI: 10.1074/Jbc.M700253200  1
2007 Turk BE. Manipulation of host signalling pathways by anthrax toxins. The Biochemical Journal. 402: 405-17. PMID 17313374 DOI: 10.1042/BJ20061891  0.01
2006 Turk BE, Hutti JE, Cantley LC. Determining protein kinase substrate specificity by parallel solution-phase assay of large numbers of peptide substrates Nature Protocols. 1: 375-379. PMID 17406259 DOI: 10.1038/Nprot.2006.57  1
2006 Fu Z, Larson KA, Chitta RK, Parker SA, Turk BE, Lawrence MW, Kaldis P, Galaktionov K, Cohn SM, Shabanowitz J, Hunt DF, Sturgill TW. Identification of yin-yang regulators and a phosphorylation consensus for male germ cell-associated kinase (MAK)-related kinase. Molecular and Cellular Biology. 26: 8639-54. PMID 16954377 DOI: 10.1128/Mcb.00816-06  1
2006 Turk BE, Lee DH, Yamakoshi Y, Klingenhoff A, Reichenberger E, Wright JT, Simmer JP, Komisarof JA, Cantley LC, Bartlett JD. MMP-20 is predominately a tooth-specific enzyme with a deep catalytic pocket that hydrolyzes type V collagen Biochemistry. 45: 3863-3874. PMID 16548514 DOI: 10.1021/Bi052252O  1
2005 Bullock AN, Debreczeni J, Amos AL, Knapp S, Turk BE. Structure and substrate specificity of the Pim-1 kinase. The Journal of Biological Chemistry. 280: 41675-82. PMID 16227208 DOI: 10.1074/jbc.M510711200  1
2005 Turk BE. Measuring kinase activity: finding needles in a haystack. Nature Methods. 2: 251-2. PMID 15782214 DOI: 10.1038/nmeth0405-251  0.01
2004 Turk BE, Cantley LC. Peptide libraries: at the crossroads of proteomics and bioinformatics. Drug Discovery Today. 9: S47-52. PMID 23573644  1
2004 Hutti JE, Jarrell ET, Chang JD, Abbott DW, Storz P, Toker A, Cantley LC, Turk BE. A rapid method for determining protein kinase phosphorylation specificity. Nature Methods. 1: 27-9. PMID 15782149 DOI: 10.1038/Nmeth708  1
2004 Williamson AL, Lecchi P, Turk BE, Choe Y, Hotez PJ, McKerrow JH, Cantley LC, Sajid M, Craik CS, Loukas A. A multi-enzyme cascade of hemoglobin proteolysis in the intestine of blood-feeding hookworms. The Journal of Biological Chemistry. 279: 35950-7. PMID 15199048 DOI: 10.1074/Jbc.M405842200  1
2004 Turk BE, Cantley LC. Using peptide libraries to identify optimal cleavage motifs for proteolytic enzymes. Methods (San Diego, Calif.). 32: 398-405. PMID 15003602 DOI: 10.1016/J.Ymeth.2003.10.003  1
2004 Panchal RG, Hermone AR, Nguyen TL, Wong TY, Schwarzenbacher R, Schmidt J, Lane D, McGrath C, Turk BE, Burnett J, Aman MJ, Little S, Sausville EA, Zaharevitz DW, Cantley LC, et al. Identification of small molecule inhibitors of anthrax lethal factor Nature Structural and Molecular Biology. 11: 67-72. PMID 14718925 DOI: 10.1038/Nsmb711  1
2004 Turk BE, Wong TY, Schwarzenbacher R, Jarrell ET, Leppla SH, Collier RJ, Liddington RC, Cantley LC. The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor. Nature Structural & Molecular Biology. 11: 60-6. PMID 14718924 DOI: 10.1038/Nsmb708  1
2003 Martins LM, Turk BE, Cowling V, Borg A, Jarrell ET, Cantley LC, Downward J. Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi. The Journal of Biological Chemistry. 278: 49417-27. PMID 14512424 DOI: 10.1074/Jbc.M308659200  1
2003 Turk BE, Cantley LC. Peptide libraries: at the crossroads of proteomics and bioinformatics. Current Opinion in Chemical Biology. 7: 84-90. PMID 12547431 DOI: 10.1016/S1367-5931(02)00004-2  1
2002 Park HI, Turk BE, Gerkema FE, Cantley LC, Sang QX. Peptide substrate specificities and protein cleavage sites of human endometase/matrilysin-2/matrix metalloproteinase-26. The Journal of Biological Chemistry. 277: 35168-75. PMID 12119297 DOI: 10.1074/Jbc.M205071200  1
2001 Turk BE, Huang LL, Piro ET, Cantley LC. Determination of protease cleavage site motifs using mixture-based oriented peptide libraries Nature Biotechnology. 19: 661-667. PMID 11433279 DOI: 10.1038/90273  1
2001 Bertenshaw GP, Turk BE, Hubbard SJ, Matters GL, Bylander JE, Crisman JM, Cantley LC, Bond JS. Marked Differences between Metalloproteases Meprin A and B in Substrate and Peptide Bond Specificity Journal of Biological Chemistry. 276: 13248-13255. PMID 11278902 DOI: 10.1074/Jbc.M011414200  1
1999 Turk BE, Griffith EC, Wolf S, Biemann K, Chang YH, Liu JO. Selective inhibition of amino-terminal methionine processing by TNP-470 and ovalicin in endothelial cells. Chemistry & Biology. 6: 823-33. PMID 10574784 DOI: 10.1016/S1074-5521(99)80129-X  1
1998 Niwayama S, Loh C, Turk BE, Liu JO, Miyachi H, Hashimoto Y. Enhanced potency of perfluorinated thalidomide derivatives for inhibition of LPS-induced tumor necrosis factor-α production is associated with a change of mechanism of action Bioorganic and Medicinal Chemistry Letters. 8: 1071-1076. PMID 9871710 DOI: 10.1016/S0960-894X(98)00171-1  1
1998 Turk BE, Su Z, Liu JO. Synthetic analogues of TNP-470 and ovalicin reveal a common molecular basis for inhibition of angiogenesis and immunosuppression Bioorganic and Medicinal Chemistry. 6: 1163-1169. PMID 9784858 DOI: 10.1016/S0968-0896(98)00078-9  1
1997 Griffith EC, Su Z, Turk BE, Chen S, Chang YH, Wu Z, Biemann K, Liu JO. Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin. Chemistry & Biology. 4: 461-71. PMID 9224570 DOI: 10.1016/S1074-5521(97)90198-8  1
1996 Niwayama S, Turk BE, Liu JO. Potent inhibition of tumor necrosis factor-α production by tetrafluorothalidomide and tetrafluorophthalimides Journal of Medicinal Chemistry. 39: 3044-3045. PMID 8759624 DOI: 10.1021/Jm960284R  1
1996 Turk BE, Jiang H, Liu JO. Binding of thalidomide to α1-acid glycoprotein may be involved in its inhibition of tumor necrosis factor α production Proceedings of the National Academy of Sciences of the United States of America. 93: 7552-7556. PMID 8755512 DOI: 10.1073/Pnas.93.15.7552  1
Show low-probability matches.