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Paul A. Clarke, Ph.D - Publications

Affiliations: 
1996-1999 Chemistry Florida State University, Tallahassee, FL, United States 
 1999-1999 Chemistry University of Exeter, Exeter, England, United Kingdom 
 1999-2006 Chemistry University of Nottingham, Nottingham, England, United Kingdom 
 2006- Chemistry University of York, York, England, United Kingdom 
Area:
Natural product synthesis
Website:
http://www.york.ac.uk/chemistry/staff/academic/a-c/pclarke/
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52/364 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Maddocks CJ, Ermanis K, Clarke PA. Asymmetric "Clip-Cycle" Synthesis of Pyrrolidines and Spiropyrrolidines. Organic Letters. PMID 32991808 DOI: 10.1021/acs.orglett.0c03090  0.335
2020 Hawkins K, Patterson A, Clarke PA, Smith DK. Catalytic Gels for a Prebiotically-Relevant Asymmetric Aldol Reaction in Water: From Organocatalyst Design to Hydrogel Discovery and Back Again. Journal of the American Chemical Society. PMID 32023044 DOI: 10.1021/Jacs.9B13156  0.356
2019 Vagkidis N, Brown AJ, Clarke PA. Evaluation of Amino Nitriles and an Amino Imidate as Organo­catalysts in Aldol Reactions Synthesis. 51: 4106-4112. DOI: 10.1055/S-0039-1690150  0.308
2018 Griggs SD, Thompson N, Tape DT, Fabre M, Clarke PA. Correction: Synthesis of highly substituted 2-spiropiperidines. Organic & Biomolecular Chemistry. PMID 30095852 DOI: 10.1039/C8Ob90117A  0.319
2018 Griggs SD, Thompson N, Tape DT, Fabre M, Clarke PA. Synthesis of highly substituted 2-spiropiperidines. Organic & Biomolecular Chemistry. PMID 30067258 DOI: 10.1039/C8Ob01272E  0.434
2018 Griggs SD, Tape DT, Clarke PA. Strategies for the synthesis of spiropiperidines - a review of the last 10 years. Organic & Biomolecular Chemistry. PMID 29993083 DOI: 10.1039/C8Ob01271G  0.362
2017 Steer AM, Bia N, Smith DK, Clarke PA. Prebiotic synthesis of 2-deoxy-d-ribose from interstellar building blocks promoted by amino esters or amino nitriles. Chemical Communications (Cambridge, England). PMID 28884758 DOI: 10.1039/C7Cc06083A  0.339
2017 Griggs SD, Thompson N, Tape DT, Fabre M, Clarke PA. A Two-Step Synthesis of 2-Spiropiperidines. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 28561323 DOI: 10.1002/Chem.201702467  0.347
2017 Ermanis K, Hsiao YT, Kaya U, Jeuken A, Clarke PA. The stereodivergent formation of 2,6-cis and 2,6-trans-tetrahydropyrans: experimental and computational investigation of the mechanism of a thioester oxy-Michael cyclization. Chemical Science. 8: 482-490. PMID 28451195 DOI: 10.1039/C6Sc03478K  0.356
2016 Clarke PA, Nasir NM, Sellars PB, Peter AM, Lawson CA, Burroughs JL. Synthesis of 2,6-trans- and 3,3,6-trisubstituted tetrahydropyran-4-ones from Maitland-Japp derived 2H-dihydropyran-4-ones: a total synthesis of diospongin B. Organic & Biomolecular Chemistry. PMID 27340028 DOI: 10.1039/C6Ob01182A  0.417
2015 Rayner PJ, Smith JC, Denneval C, O'Brien P, Clarke PA, Horan RA. Mechanistic interrogation of the asymmetric lithiation-trapping of N-thiopivaloyl azetidine and pyrrolidine. Chemical Communications (Cambridge, England). PMID 26620913 DOI: 10.1039/C5Cc08690F  0.309
2015 Clarke PA, Sellars PB, Nasir NM. A Maitland-Japp inspired synthesis of dihydropyran-4-ones and their stereoselective conversion to functionalised tetrahydropyran-4-ones. Organic & Biomolecular Chemistry. 13: 4743-50. PMID 25804802 DOI: 10.1039/C5Ob00292C  0.409
2014 Nasir NM, Ermanis K, Clarke PA. Strategies for the construction of tetrahydropyran rings in the synthesis of natural products. Organic & Biomolecular Chemistry. 12: 3323-35. PMID 24744139 DOI: 10.1039/C4Ob00423J  0.399
2012 Clarke PA, Ermanis K. Synthesis of the C20-C32 tetrahydropyran core of the phorboxazoles and the C22 epimer via a stereodivergent Michael reaction. Organic Letters. 14: 5550-3. PMID 23088315 DOI: 10.1021/Ol3026523  0.347
2012 Clarke PA, Mistry N, Thomas GH. Synthesis of the complete series of mono acetates of N-acetyl-D-neuraminic acid. Organic & Biomolecular Chemistry. 10: 529-35. PMID 22095310 DOI: 10.1039/C1Ob06348K  0.334
2011 Iqbal M, Black RJ, Winn J, Reeder AT, Blake AJ, Clarke PA. Studies on transannulation reactions across a nine-membered ring: the synthesis of natural product-like structures. Organic & Biomolecular Chemistry. 9: 5062-78. PMID 21597625 DOI: 10.1039/C1Ob05448A  0.407
2011 Clarke PA, Santos S, Mistry N, Burroughs L, Humphries AC. The asymmetric Maitland-Japp reaction and its application to the construction of the C1-C19 bis-pyran unit of phorboxazole B. Organic Letters. 13: 624-7. PMID 21247215 DOI: 10.1021/Ol102860R  0.364
2011 Clarke PA, Sellars PB, Mistry N. Diastereoselective synthesis of functionalized 2-methyltetrahydropyran-4- ones Tetrahedron Letters. 52: 3654-3656. DOI: 10.1016/J.Tetlet.2011.05.022  0.401
2011 Clarke PA, Winn J. Synthesis of an austrodorane sesquiterpenoid core via a transannular Prins cyclization Tetrahedron Letters. 52: 1469-1472. DOI: 10.1016/J.Tetlet.2011.01.093  0.384
2011 Clarke PA. Strategies for the synthesis of tetrahydropyran-containing natural products Tetrahedron. 67: 4959. DOI: 10.1016/J.Tet.2011.04.069  0.352
2011 Iqbal M, Mistry N, Clarke PA. An asymmetric Maitland-Japp reaction: A highly enantioselective synthesis of tetrahydropyran-4-ones Tetrahedron. 67: 4960-4966. DOI: 10.1016/J.Tet.2011.04.043  0.457
2010 Clarke PA, Black RJG, Iqbal M. Investigation of transannelation reactions across a cyclononene ring Synlett. 543-546. DOI: 10.1055/S-0029-1218390  0.398
2010 Clarke PA, Hargreaves JM, Woollaston DJ, Sarmiento RMR. Synthetic studies on the phorboxazoles: A short synthesis of an epi-C23 tetrahydropyran core Tetrahedron Letters. 51: 4731-4733. DOI: 10.1016/J.Tetlet.2010.07.012  0.462
2009 Clarke PA, Cridland AP, Rolla GA, Iqbal M, Bainbridge NP, Whitwood AC, Wilson C. Studies on the synthesis of the ABC rings of (+/-)-hexacyclinic acid. The Journal of Organic Chemistry. 74: 7812-21. PMID 19813768 DOI: 10.1021/Jo901547K  0.417
2009 Clarke PA, Reeder AT, Winn J. Transannulation reactions in the synthesis of natural products Synthesis. 691-709. DOI: 10.1055/S-0028-1083355  0.329
2008 Clarke PA, Zaytsev AV, Morgan TW, Whitwood AC, Wilson C. One-pot synthesis of functionalized piperid-4-ones: a four-component condensation. Organic Letters. 10: 2877-80. PMID 18533668 DOI: 10.1021/Ol801051G  0.352
2007 Clarke PA, Santos S, Martin WHC. Combining pot, atom and step economy (PASE) in organic synthesis. Synthesis of tetrahydropyran-4-ones Green Chemistry. 9: 438-440. DOI: 10.1039/B700923B  0.506
2007 Clarke PA, Zaytzev AV, Whitwood AC. Pot, atom and step economic (PASE) synthesis of highly functionalized piperidines: a five-component condensation Tetrahedron Letters. 48: 5209-5212. DOI: 10.1016/J.Tetlet.2007.05.141  0.339
2007 Clarke PA, Rolla GA, Cridland AP, Gill AA. An improved synthesis of (2E,4Z)-6-(benzyloxy)-4-bromohexa-2,4-dien-1-ol Tetrahedron. 63: 9124-9128. DOI: 10.1016/J.Tet.2007.06.071  0.364
2006 Clarke PA, Black RJG, Blake AJ. Enantioselective synthesis of the bicyclo[4.3.0]nonane ring system of the pinguisane-type sesquiterpenoids via a Brønsted acid promoted transannular enol alkylation Tetrahedron Letters. 47: 1453-1455. DOI: 10.1016/J.Tetlet.2005.12.084  0.398
2006 Clarke PA, Santos S. Strategies for the formation of tetrahydropyran rings in the synthesis of natural products European Journal of Organic Chemistry. 2045-2053. DOI: 10.1002/Ejoc.200500964  0.349
2005 Clarke PA, Martin WH, Hargreaves JM, Wilson C, Blake AJ. The one-pot, multi-component construction of highly substituted tetrahydropyran-4-ones using the Maitland-Japp reaction. Organic & Biomolecular Chemistry. 3: 3551-63. PMID 16172694 DOI: 10.1039/B508252H  0.549
2005 Clarke PA, Cridland AP. A racemic synthesis of an AB-ring system of hexacyclinic acid. Organic Letters. 7: 4221-4. PMID 16146392 DOI: 10.1021/Ol051633R  0.398
2005 Clarke PA, Martin WH, Hargreaves JM, Wilson C, Blake AJ. Revisiting the Maitland-Japp reaction. Concise construction of highly functionalised tetrahydropyran-4-ones. Chemical Communications (Cambridge, England). 1061-3. PMID 15719116 DOI: 10.1039/B416247A  0.531
2005 Clarke PA, Martin WHC. Exploiting the Maitland-Japp reaction: A synthesis of (±)- centrolobine Tetrahedron. 61: 5433-5438. DOI: 10.1016/J.Tet.2005.04.011  0.502
2005 Clarke PA, Davie RL, Peace S. Synthesis of the B-ring of FR182877. Investigation of the reactions of 6-fumaryl 1,3,8-nonatrienes Tetrahedron. 61: 2335-2351. DOI: 10.1016/J.Tet.2005.01.014  0.455
2005 Clarke PA, Grist M, Ebden M, Wilson C, Blake AJ. Synthetic studies on the DEF-rings of FR182877 and hexacyclinic acid Tetrahedron. 61: 353-363. DOI: 10.1016/J.Tet.2004.10.095  0.446
2005 Clarke PA, Martin WHC. Exploiting the Maitland—Japp Reaction: A Synthesis of (.+-.)-Centrolobine Cheminform. 36. DOI: 10.1002/chin.200541206  0.496
2005 Clarke PA, Martin WHC. An Expedient Synthesis of (.+-.)-Centrolobine. Cheminform. 36. DOI: 10.1002/chin.200513235  0.455
2004 Clarke PA, Cridland AP. Total synthesis highlights Annual Reports On the Progress of Chemistry - Section B. 100: 91-111. DOI: 10.1039/B402095M  0.336
2004 Clarke PA, Martin WHC. An expedient synthesis of (±)-centrolobine Tetrahedron Letters. 45: 9061-9063. DOI: 10.1016/J.Tetlet.2004.10.035  0.534
2004 Clarke PA, Grist M, Ebden M. An iodocyclisation/elimination approach to a DEF-ring core of FR182877 Tetrahedron Letters. 45: 927-929. DOI: 10.1016/J.Tetlet.2003.11.105  0.404
2003 Clarke PA, Grist M, Ebden M, Wilson C. Synthesis of a model DEF-ring core of hexacyclinic acid Chemical Communications. 9: 1560-1561. DOI: 10.1039/B303706A  0.418
2003 Clarke PA, Martin WHC. Synthetic methods: Part (v) protecting groups Annual Reports On the Progress of Chemistry - Section B. 99: 84-103. DOI: 10.1039/B212008A  0.314
2002 Clarke PA, Martin WH. Diastereoselective synthesis of highly substituted tetrahydropyran-4-ones. Organic Letters. 4: 4527-9. PMID 12465929 DOI: 10.1021/Ol027081J  0.553
2002 Clarke PA, Kayaleh NE, Smith MA, Baker JR, Bird SJ, Chan C. A one-step procedure for the monoacylation of symmetrical 1,2-diols. The Journal of Organic Chemistry. 67: 5226-31. PMID 12126410 DOI: 10.1021/Jo0257041  0.357
2002 Clarke PA. Selective mono-acylation of meso- and C2-symmetric 1,3- and 1,4-diols Tetrahedron Letters. 43: 4761-4763. DOI: 10.1016/S0040-4039(02)00935-8  0.337
2002 Clarke PA, Davie RL, Peace S. On the Diels-Alder reactions and the Lewis acid induced rearrangements of 6-fumaryl 1,3,8-nonatrienes Tetrahedron Letters. 43: 2753-2756. DOI: 10.1016/S0040-4039(02)00377-5  0.399
2000 Buck RT, Clarke PA, Coe DM, Drysdale MJ, Ferris L, Haigh D, Moody CJ, Pearson ND, Swann E. The carbenoid approach to peptide synthesis. Chemistry (Weinheim An Der Bergstrasse, Germany). 6: 2160-7. PMID 10926221 DOI: 10.1002/1521-3765(20000616)6:12<2160::Aid-Chem2160>3.0.Co;2-Y  0.379
2000 Clarke PA, Holton RA, Kayaleh NE. Direct one step mono-functionalisation of symmetrical 1,2-diols Tetrahedron Letters. 41: 2687-2690. DOI: 10.1016/S0040-4039(00)00224-0  0.401
1996 Armstrong A, Barsanti PA, Clarke PA, Wood A. Ketone-directed peracid epoxidation of cyclic alkenes Journal of the Chemical Society - Perkin Transactions 1. 1373-1380. DOI: 10.1039/P19960001373  0.562
1996 Armstrong A, Clarke PA, Wood A. Evidence that a dioxirane is not responsible for alkene epoxidation in a ketone–Oxone® system Chemical Communications. 849-850. DOI: 10.1039/Cc9960000849  0.485
Low-probability matches (unlikely to be authored by this person)
2003 Clarke PA, Arnold PL, Smith MA, Natrajan LS, Wilson C, Chan C. Mechanistic insight into the lanthanide(III) salt catalysed monoacylation of symmetrical diols from structural models. Chemical Communications (Cambridge, England). 2588-9. PMID 14594294 DOI: 10.1039/B308171K  0.288
2010 Burroughs L, Vale ME, Gilks JA, Forintos H, Hayes CJ, Clarke PA. Efficient asymmetric organocatalytic formation of erythrose and threose under aqueous conditions. Chemical Communications (Cambridge, England). 46: 4776-8. PMID 20485830 DOI: 10.1039/C0Cc00613K  0.288
2016 Clarke P, Esdar C, Mallinger A, Schiemann K, Waalboer D, Crumpler S, Rink C, Stieber F, Calderini M, Adeniji-Popoola O, Ortiz-Ruiz M, Samant RS, Czodrowski P, Musil D, Schwarz D, et al. Abstract 3025: Discovery of preclinical development candidate inhibitors of the mediator complex-associated kinases CDK8 and CDK19 and evaluation of their therapeutic potential Cancer Research. 76: 3025-3025. DOI: 10.1158/1538-7445.Am2016-3025  0.286
2016 Ruiz MJO, Popoola O, Mallinger A, Gowan S, Court W, Box G, Valenti M, Brandon ADH, Te-Poele R, Workman P, Schiemann K, Esdar C, Wienke D, Blagg J, Clarke P, et al. Abstract 4355: Elucidation of the different roles of CDK8 and CDK19 in colorectal cancer (CRC) using CRISPR gene editing technology Cancer Research. 76: 4355-4355. DOI: 10.1158/1538-7445.Am2016-4355  0.285
2012 Burroughs L, Clarke PA, Forintos H, Gilks JA, Hayes CJ, Vale ME, Wade W, Zbytniewski M. Asymmetric organocatalytic formation of protected and unprotected tetroses under potentially prebiotic conditions. Organic & Biomolecular Chemistry. 10: 1565-70. PMID 22245755 DOI: 10.1039/C1Ob06798B  0.279
1998 Holton RA, Zhang Z, Clarke PA, Nadizadeh H, Procter DJ. Selective protection of the C(7) and C(10) hydroxyl groups in 10- deacetyl baccatin III Tetrahedron Letters. 39: 2883-2886. DOI: 10.1016/S0040-4039(98)00424-9  0.279
2018 Licciardello MP, Clarke PA, Workman P. Abstract 2896: A genome-wide CRISPR/Cas9 pooled screen identifies EML4-ALK variant-specific synthetic lethal partners of HSP90 inhibitors Cancer Research. 78: 2896-2896. DOI: 10.1158/1538-7445.Am2018-2896  0.276
1996 Armstrong A, Barsanti PA, Clarke PA, Wood A. Ketone-directed peracid epoxidation of cyclic alkenes Journal of the Chemical Society - Perkin Transactions 1. 1373-1380.  0.275
2016 Popoola OO, Samant R, Ortiz-Ruiz M, Mallinger A, Court W, Hobbs S, Te-Poele R, Stubbs M, Burke R, Esdar C, Schiemann K, Wienke D, Eccles S, Blagg J, Workman P, ... Clarke P, et al. Abstract 3869: Phosphoproteomic-based identification of CDK8/CDK19 substrates in colorectal cancer Cancer Research. 76: 3869-3869. DOI: 10.1158/1538-7445.Am2016-3869  0.274
2022 Alomari K, Sai Pavan Chakravarthy N, Duchadeau B, Ermanis K, Clarke PA. Enantioselective "clip-cycle" synthesis of di-, tri- and spiro-substituted tetrahydropyrans. Organic & Biomolecular Chemistry. PMID 35044408 DOI: 10.1039/d2ob00023g  0.272
2018 Sharp SY, Chessum NE, Caldwell JJ, Powers MV, Pasqua AE, Wilding B, Collins I, Ozer B, Rowlands M, Stubbs M, Burke R, Montfort RLv, Cheeseman MD, Clarke PA, Workman P, et al. Abstract 2976: Confirmation of in-cell target engagement using the proteolysis targeting chimeras (PROTACs) against pirin Cancer Research. 78: 2976-2976. DOI: 10.1158/1538-7445.Am2018-2976  0.268
2010 Al-Saffar NM, Jackson LE, Raynaud FI, Clarke PA, Ramírez de Molina A, Lacal JC, Workman P, Leach MO. The phosphoinositide 3-kinase inhibitor PI-103 downregulates choline kinase alpha leading to phosphocholine and total choline decrease detected by magnetic resonance spectroscopy. Cancer Research. 70: 5507-17. PMID 20551061 DOI: 10.1158/0008-5472.Can-09-4476  0.257
2009 Saturno G, Clarke PA, Workman P. Abstract C7: Sensitization of human colorectal cancer cells to TRAIL induced‐apoptosis following inhibition of PI3K or HSP90 Molecular Cancer Therapeutics. 8. DOI: 10.1158/1535-7163.Targ-09-C7  0.254
1999 Workman P, Pestell KE, Hostein I, Maloney A, Medlow C, Walton M, Clarke PA. Array technology in the molecular pharmacology of anticancer agents Nature Genetics. 23: 82-82. DOI: 10.1038/14428  0.246
2004 Guillard S, Clarke PA, Poele Rt, Stefano FD, Raynaud F, Workman P. 379 Characterisation of a novel class I isoform selective phosphatidyl-inositol 3-kinase inhibitor in glioma Ejc Supplements. 2: 114. DOI: 10.1016/S1359-6349(04)80386-0  0.243
2004 Workman P, Raynaud F, Clarke P, Poele RT, Eccles S, Kelland L, Stefano FD, Ahmadi K, Parker P, Waterfield M. 414A Pharmacological properties and in vitro and in vivo antitumour activity of the potent and selective PI3 kinase inhibitor PI103 Ejc Supplements. 2: 124. DOI: 10.1016/S1359-6349(04)80422-1  0.238
2008 Clarke PA, Welsh L, Valenti M, Eccles S, Workman P. 145 POSTER Hsp90 inhibitors target addiction to mutant oncoproteins in colorectal cancer Ejc Supplements. 6: 47. DOI: 10.1016/S1359-6349(08)72077-9  0.238
2006 Raynaud F, Eccles S, Clarke P, Hayes A, Stefano FD, Ahmad Z, Guillard S, Patel S, Workman P. 568 POSTER In vitro and in vivo pharmacological properties of the potent phosphatidylinositol 3-kinase (P13K) family inhibitor Pl103 Ejc Supplements. 4: 172. DOI: 10.1016/S1359-6349(06)70573-0  0.234
2016 Clarke PA, Nasir NM, Sellars PB, Peter AM, Lawson CA, Burroughs JL. ChemInform Abstract: Synthesis of 2,6-trans- and 3,3,6-Trisubstituted Tetrahydropyran-4-ones from Maitland-Japp Derived 2H-Dihydropyran-4-ones: A Total Synthesis of Diospongin B. Cheminform. 47. DOI: 10.1002/chin.201649147  0.232
2017 Clarke PA, Ortiz-Ruiz M, Poele RT, Adeniji-Popoola O, Box G, Esdar C, Ewan K, Gowan S, Brandon ADH, Hewitt P, Kaufmann W, Mallinger A, Raynaud F, Rohdich F, Schiemann K, et al. Abstract 129: Assessing the mechanism and therapeutic potential of modulators of the human mediator complex-associated protein kinases CDK8 and CDK19 Cancer Research. 77: 129-129. DOI: 10.1158/1538-7445.Am2017-129  0.231
2008 Clarke PA, Zaytsev AV, Whitwood AC. Pot, atom, and step economic (PASE) synthesis of highly substituted piperidines: A five-component condensation Synthesis. 3530-3532. DOI: 10.1055/s-0028-1083182  0.227
2010 ARMSTRONG A, BARSANTI PA, CLARKE PA, WOOD A. ChemInform Abstract: Ketone-Directed Peracid Epoxidation. Cheminform. 26: no-no. DOI: 10.1002/chin.199501079  0.215
2016 Lampis A, Cascione L, Burke R, Clarke P, Simbolo M, Scarpa A, Bosma E, Yu S, Cole R, Stubbs M, Sharp S, Montfort Rv, Hahne J, Fassan M, Workman P, et al. HSP-90 Inhibition is a Promising Therapeutic Strategy in Cholangiocarcinoma and MIR-21 may Serve as a Biomarker of Sensitivity Journal of Hepatology. 64. DOI: 10.1016/S0168-8278(16)01009-6  0.214
2006 Workman P, Clarke PA, Guillard S, Raynaud FI. Correction: Corrigendum: Drugging the PI3 kinome Nature Biotechnology. 24: 1033-1033. DOI: 10.1038/Nbt0806-1033B  0.209
2016 Lampis A, Cascione L, Burke R, Clarke P, Simbolo M, Scarpa A, Bosma E, Yu S, Cole R, Stubbs M, Sharp S, Montfort RV, Hahne JC, Fassan M, Workman P, et al. Abstract 1069: MiR-21 may serve as a predictive biomarker of response in the assessment of efficacy of HSP-90 inhibition in gastrointestinal (GI) cancers Cancer Research. 76: 1069-1069. DOI: 10.1158/1538-7445.Am2016-1069  0.208
1999 Clarke PA, George M, Cunningham D, Swift I, Workman P. Analysis of tumour gene expression following chemotherapeutic treatment of patients with bowel cancer Nature Genetics. 23: 39-39. DOI: 10.1038/14287  0.205
2015 Lynch AJ, Thackway R, Specht A, Beggs PJ, Brisbane S, Burns EL, Byrne M, Capon SJ, Casanova MT, Clarke PA, Davies JM, Dovers S, Dwyer RG, Ens E, Fisher DO, et al. Transdisciplinary synthesis for ecosystem science, policy and management: The Australian experience. The Science of the Total Environment. PMID 25957785 DOI: 10.1016/J.Scitotenv.2015.04.100  0.198
2007 Rao S, Cunningham D, Benson M, Poele RT, Welsh L, Starling N, Norman A, Saffery C, Workman P, Clarke P. A prospective study to evaluate the role of gene expression profiles (GEP) in predicting clinical outcome of patients (pts) receiving preoperative chemotherapy for oesophagogastric (OG) cancer Journal of Clinical Oncology. 25: 4501-4501. DOI: 10.1200/Jco.2007.25.18_Suppl.4501  0.187
2013 Clarke PA, Ermanis K. The development of Pot, Atom and Step Economic (PASE) synthesis of functionalised tetrahydropyrans, dihydropyrans and piperidines Current Organic Chemistry. 17: 2025-2037. DOI: 10.2174/13852728113179990095  0.186
2016 Mallinger A, Schiemann K, Rink C, Sejberg J, Honey MA, Czodrowski P, Stubbs M, Poeschke O, Busch M, Schneider R, Schwarz D, Musil D, Burke R, Urbahns K, Workman P, ... ... Clarke PA, et al. 2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19. Acs Medicinal Chemistry Letters. 7: 573-8. PMID 27326329 DOI: 10.1021/Acsmedchemlett.6B00022  0.173
2008 Folkes AJ, Ahmadi K, Alderton WK, Alix S, Baker SJ, Box G, Chuckowree IS, Clarke PA, Depledge P, Eccles SA, Friedman LS, Hayes A, Hancox TC, Kugendradas A, Lensun L, et al. The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer . Journal of Medicinal Chemistry. 51: 5522-32. PMID 18754654 DOI: 10.1021/jm800295d  0.16
2007 Sharp SY, Boxall K, Rowlands M, Prodromou C, Roe SM, Maloney A, Powers M, Clarke PA, Box G, Sanderson S, Patterson L, Matthews TP, Cheung KM, Ball K, Hayes A, et al. In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors. Cancer Research. 67: 2206-16. PMID 17332351 DOI: 10.1158/0008-5472.CAN-06-3473  0.158
2020 Frame S, Saladino C, MacKay C, Atrash B, Sheldrake P, McDonald E, Clarke PA, Workman P, Blake D, Zheleva D. Fadraciclib (CYC065), a novel CDK inhibitor, targets key pro-survival and oncogenic pathways in cancer. Plos One. 15: e0234103. PMID 32645016 DOI: 10.1371/journal.pone.0234103  0.157
1996 Armstrong A, Clarke PA, Wood A. Evidence that a dioxirane is not responsible for alkene epoxidation in a ketone-Oxone® system Chemical Communications. 849-850.  0.155
2011 Large JM, Torr JE, Raynaud FI, Clarke PA, Hayes A, Stefano Fd, Urban F, Shuttleworth SJ, Saghir N, Sheldrake P, Workman P, McDonald E. Preparation and evaluation of trisubstituted pyrimidines as phosphatidylinositol 3-kinase inhibitors. 3-Hydroxyphenol analogues and bioisosteric replacements. Bioorganic & Medicinal Chemistry. 19: 836-51. PMID 21216151 DOI: 10.1016/j.bmc.2010.12.006  0.146
2016 Mallinger A, Schiemann K, Rink C, Stieber F, Calderini M, Crumpler S, Stubbs M, Adeniji-Popoola O, Poeschke O, Busch M, Czodrowski P, Musil D, Schwarz D, Ortiz-Ruiz MJ, Schneider R, ... ... Clarke PA, et al. Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19. Journal of Medicinal Chemistry. PMID 26796641 DOI: 10.1021/Acs.Jmedchem.5B01685  0.145
2017 Whittaker SR, Mallinger A, Workman P, Clarke PA. Inhibitors of cyclin-dependent kinases as cancer therapeutics. Pharmacology & Therapeutics. PMID 28174091 DOI: 10.1016/j.pharmthera.2017.02.008  0.14
2016 Vaughan L, Clarke PA, Barker K, Chanthery Y, Gustafson CW, Tucker E, Renshaw J, Raynaud F, Li X, Burke R, Jamin Y, Robinson SP, Pearson A, Maira M, Weiss WA, et al. Inhibition of mTOR-kinase destabilizes MYCN and is a potential therapy for MYCN-dependent tumors. Oncotarget. PMID 27438153 DOI: 10.18632/Oncotarget.10544  0.139
2003 Maloney A, Clarke PA, Workman P. Genes and proteins governing the cellular sensitivity to HSP90 inhibitors: a mechanistic perspective. Current Cancer Drug Targets. 3: 331-41. PMID 14529385 DOI: 10.2174/1568009033481822  0.139
2013 Couty S, Westwood IM, Kalusa A, Cano C, Travers J, Boxall K, Chow CL, Burns S, Schmitt J, Pickard L, Barillari C, McAndrew PC, Clarke PA, Linardopoulos S, Griffin RJ, et al. The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design. Oncotarget. 4: 1647-61. PMID 24072592 DOI: 10.18632/Oncotarget.1255  0.138
2004 Clarke PA, Grist M, Ebden M. An Iodocyclization/Elimination Approach to a DEF-Ring Core (III) of FR182877 (IV). Cheminform. 35. DOI: 10.1002/chin.200421214  0.137
2016 Czodrowski P, Mallinger A, Wienke D, Esdar C, Poeschke O, Busch M, Rohdich F, Eccles SA, Ortiz Ruiz MJ, Schneider R, Raynaud FI, Clarke PA, Musil D, Schwarz D, Dale TC, et al. Structure-based optimization of potent, selective and orally bioavailable CDK8 inhibitors discovered by high throughput screening. Journal of Medicinal Chemistry. PMID 27490956 DOI: 10.1021/Acs.Jmedchem.6B00597  0.135
2014 Samant RS, Clarke PA, Workman P. E3 ubiquitin ligase Cullin-5 modulates multiple molecular and cellular responses to heat shock protein 90 inhibition in human cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 111: 6834-9. PMID 24760825 DOI: 10.1073/pnas.1322412111  0.133
2012 Samant RS, Clarke PA, Workman P. The expanding proteome of the molecular chaperone HSP90. Cell Cycle (Georgetown, Tex.). 11: 1301-8. PMID 22421145 DOI: 10.4161/cc.19722  0.127
2017 Whittaker SR, Barlow C, Martin MP, Mancusi C, Wagner S, Self A, Barrie E, Te Poele R, Sharp S, Brown N, Wilson S, Jackson W, Fischer PM, Clarke PA, Walton MI, et al. Molecular profiling and combinatorial activity of CCT068127: A potent CDK2 and CDK9 inhibitor. Molecular Oncology. PMID 29063678 DOI: 10.1002/1878-0261.12148  0.126
2009 Raynaud FI, Eccles SA, Patel S, Alix S, Box G, Chuckowree I, Folkes A, Gowan S, De Haven Brandon A, Di Stefano F, Hayes A, Henley AT, Lensun L, Pergl-Wilson G, Robson A, ... ... Clarke PA, et al. Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941. Molecular Cancer Therapeutics. 8: 1725-38. PMID 19584227 DOI: 10.1158/1535-7163.MCT-08-1200  0.125
2013 Powers MV, Valenti M, Miranda S, Maloney A, Eccles SA, Thomas G, Clarke PA, Workman P. Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX. Oncotarget. 4: 1963-75. PMID 24185264  0.123
2007 Raynaud FI, Eccles S, Clarke PA, Hayes A, Nutley B, Alix S, Henley A, Di-Stefano F, Ahmad Z, Guillard S, Bjerke LM, Kelland L, Valenti M, Patterson L, Gowan S, et al. Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases. Cancer Research. 67: 5840-50. PMID 17575152 DOI: 10.1158/0008-5472.CAN-06-4615  0.122
2016 Clarke PA, Ortiz-Ruiz MJ, TePoele R, Adeniji-Popoola O, Box G, Court W, Czasch S, El Bawab S, Esdar C, Ewan K, Gowan S, De Haven Brandon A, Hewitt P, Hobbs SM, Kaufmann W, et al. Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases. Elife. 5. PMID 27935476 DOI: 10.7554/Elife.20722  0.12
2009 Smith JR, Clarke PA, de Billy E, Workman P. Silencing the cochaperone CDC37 destabilizes kinase clients and sensitizes cancer cells to HSP90 inhibitors. Oncogene. 28: 157-69. PMID 18931700 DOI: 10.1038/onc.2008.380  0.119
2001 Hostein I, Robertson D, DiStefano F, Workman P, Clarke PA. Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin results in cytostasis and apoptosis. Cancer Research. 61: 4003-9. PMID 11358818  0.119
2013 Saturno G, Valenti M, De Haven Brandon A, Thomas GV, Eccles S, Clarke PA, Workman P. Combining trail with PI3 kinase or HSP90 inhibitors enhances apoptosis in colorectal cancer cells via suppression of survival signaling. Oncotarget. 4: 1185-98. PMID 23852390  0.116
2000 Clarke PA, Hostein I, Banerji U, Stefano FD, Maloney A, Walton M, Judson I, Workman P. Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone. Oncogene. 19: 4125-33. PMID 10962573 DOI: 10.1038/sj.onc.1203753  0.116
2020 Poon E, Liang T, Jamin Y, Walz S, Kwok C, Hakkert A, Barker K, Urban Z, Thway K, Zeid R, Hallsworth A, Box G, Ebus ME, Licciardello MP, Sbirkov Y, ... ... Clarke PA, et al. Orally bioavailable CDK9/2 inhibitor shows mechanism-based therapeutic potential in MYCN-driven neuroblastoma. The Journal of Clinical Investigation. PMID 33016930 DOI: 10.1172/JCI134132  0.116
2006 Hardcastle A, Boxall K, Richards J, Tomlin P, Sharp S, Clarke P, Workman P, Aherne W. Solid-phase immunoassays in mechanism-based drug discovery: their application in the development of inhibitors of the molecular chaperone heat-shock protein 90. Assay and Drug Development Technologies. 3: 273-85. PMID 15971989 DOI: 10.1089/adt.2005.3.273  0.116
2020 Milton CK, Self AJ, Clarke PA, Banerji U, Piccioni F, Root DE, Whittaker SR. A genome-scale CRISPR screen identifies the ERBB and mTOR signalling networks as key determinants of response to PI3K inhibition in pancreatic cancer. Molecular Cancer Therapeutics. PMID 32371585 DOI: 10.1158/1535-7163.Mct-19-1131  0.115
2009 Powers MV, Clarke PA, Workman P. Death by chaperone: HSP90, HSP70 or both? Cell Cycle (Georgetown, Tex.). 8: 518-26. PMID 19197160  0.115
2015 Smith JR, de Billy E, Hobbs S, Powers M, Prodromou C, Pearl L, Clarke PA, Workman P. Restricting direct interaction of CDC37 with HSP90 does not compromise chaperoning of client proteins. Oncogene. 34: 15-26. PMID 24292678 DOI: 10.1038/onc.2013.519  0.113
2020 Rogers RF, Walton MI, Cherry DL, Collins I, Clarke PA, Garrett MD, Workman P. CHK1 inhibition is synthetically lethal with loss of B-family DNA polymerase function in human lung and colorectal cancer cells. Cancer Research. PMID 32161100 DOI: 10.1158/0008-5472.Can-19-1372  0.112
2003 Clarke PA, George ML, Easdale S, Cunningham D, Swift RI, Hill ME, Tait DM, Workman P. Molecular pharmacology of cancer therapy in human colorectal cancer by gene expression profiling. Cancer Research. 63: 6855-63. PMID 14583483  0.111
2020 Antolin AA, Ameratunga M, Banerji U, Clarke PA, Workman P, Al-Lazikani B. The kinase polypharmacology landscape of clinical PARP inhibitors. Scientific Reports. 10: 2585. PMID 32066817 DOI: 10.1038/s41598-020-59074-4  0.111
2010 Workman P, Clarke PA, Raynaud FI, van Montfort RL. Drugging the PI3 kinome: from chemical tools to drugs in the clinic. Cancer Research. 70: 2146-57. PMID 20179189 DOI: 10.1158/0008-5472.CAN-09-4355  0.111
2013 Workman P, Al-Lazikani B, Clarke PA. Genome-based cancer therapeutics: targets, kinase drug resistance and future strategies for precision oncology. Current Opinion in Pharmacology. 13: 486-96. PMID 23810823 DOI: 10.1016/j.coph.2013.06.004  0.11
2015 Dale T, Clarke PA, Esdar C, Waalboer D, Adeniji-Popoola O, Ortiz-Ruiz MJ, Mallinger A, Samant RS, Czodrowski P, Musil D, Schwarz D, Schneider K, Stubbs M, Ewan K, Fraser E, et al. A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease. Nature Chemical Biology. PMID 26502155 DOI: 10.1038/Nchembio.1952  0.11
2011 Thompson R, Creavin A, O'Connell M, O'Connor B, Clarke P. Optimization of the enzyme-linked lectin assay for enhanced glycoprotein and glycoconjugate analysis. Analytical Biochemistry. 413: 114-22. PMID 21320462 DOI: 10.1016/J.Ab.2011.02.013  0.108
2009 Guillard S, Clarke PA, Te Poele R, Mohri Z, Bjerke L, Valenti M, Raynaud F, Eccles SA, Workman P. Molecular pharmacology of phosphatidylinositol 3-kinase inhibition in human glioma. Cell Cycle (Georgetown, Tex.). 8: 443-53. PMID 19177002  0.107
2014 Al-Saffar NM, Marshall LV, Jackson LE, Balarajah G, Eykyn TR, Agliano A, Clarke PA, Jones C, Workman P, Pearson AD, Leach MO. Lactate and choline metabolites detected in vitro by nuclear magnetic resonance spectroscopy are potential metabolic biomarkers for PI3K inhibition in pediatric glioblastoma. Plos One. 9: e103835. PMID 25084455 DOI: 10.1371/journal.pone.0103835  0.106
2019 Zhang C, Stockwell SR, Elbanna M, Ketteler R, Freeman J, Al-Lazikani B, Eccles S, De Haven Brandon A, Raynaud F, Hayes A, Clarke PA, Workman P, Mittnacht S. Signalling involving MET and FAK supports cell division independent of the activity of the cell cycle-regulating CDK4/6 kinases. Oncogene. PMID 31296956 DOI: 10.1038/s41388-019-0850-2  0.104
2011 Shuttleworth SJ, Silva FA, Cecil AR, Tomassi CD, Hill TJ, Raynaud FI, Clarke PA, Workman P. Progress in the preclinical discovery and clinical development of class I and dual class I/IV phosphoinositide 3-kinase (PI3K) inhibitors. Current Medicinal Chemistry. 18: 2686-714. PMID 21649578 DOI: 10.2174/092986711796011229  0.104
2013 Polier S, Samant RS, Clarke PA, Workman P, Prodromou C, Pearl LH. ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system. Nature Chemical Biology. 9: 307-12. PMID 23502424 DOI: 10.1038/nchembio.1212  0.104
2007 Maloney A, Clarke PA, Naaby-Hansen S, Stein R, Koopman JO, Akpan A, Yang A, Zvelebil M, Cramer R, Stimson L, Aherne W, Banerji U, Judson I, Sharp S, Powers M, et al. Gene and protein expression profiling of human ovarian cancer cells treated with the heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin. Cancer Research. 67: 3239-53. PMID 17409432 DOI: 10.1158/0008-5472.Can-06-2968  0.103
2019 Clarke PA, Roe T, Swabey K, Hobbs SM, McAndrew C, Tomlin K, Westwood I, Burke R, van Montfort R, Workman P. Dissecting mechanisms of resistance to targeted drug combination therapy in human colorectal cancer. Oncogene. PMID 30905967 DOI: 10.1038/s41388-019-0780-z  0.103
2008 Vaughan CK, Mollapour M, Smith JR, Truman A, Hu B, Good VM, Panaretou B, Neckers L, Clarke PA, Workman P, Piper PW, Prodromou C, Pearl LH. Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37. Molecular Cell. 31: 886-95. PMID 18922470 DOI: 10.1016/J.Molcel.2008.07.021  0.103
2015 Mallinger A, Crumpler S, Pichowicz M, Waalboer D, Stubbs M, Adeniji-Popoola O, Wood B, Smith E, Thai C, Henley AT, Georgi K, Court W, Hobbs S, Box G, Ortiz-Ruiz MJ, ... ... Clarke PA, et al. Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen. Journal of Medicinal Chemistry. 58: 1717-35. PMID 25680029 DOI: 10.1021/Jm501436M  0.102
2020 Hervieu A, Heuss SF, Zhang C, Barrow-McGee R, Joffre C, Ménard L, Clarke PA, Kermorgant S. A PI3K- and GTPase-independent Rac1-mTOR mechanism mediates MET-driven anchorage-independent cell growth but not migration. Science Signaling. 13. PMID 32576681 DOI: 10.1126/scisignal.aba8627  0.102
2012 Hoelder S, Clarke PA, Workman P. Discovery of small molecule cancer drugs: successes, challenges and opportunities. Molecular Oncology. 6: 155-76. PMID 22440008 DOI: 10.1016/J.Molonc.2012.02.004  0.1
2019 Sharp SY, Boxall K, Rowlands M, Prodromou C, Roe SM, Maloney A, Powers M, Clarke PA, Box G, Sanderson S, Patterson L, Matthews TP, Cheung KJ, Ball K, Hayes A, et al. Correction: Biological Characterization of a Novel, Synthetic Diaryl Pyrazole Resorcinol Class of Heat Shock Protein 90 Inhibitors. Cancer Research. 79: 287. PMID 30602624 DOI: 10.1158/0008-5472.CAN-18-3578  0.1
2012 Pintzas A, Zhivotovsky B, Workman P, Clarke PA, Linardopoulos S, Martinou JC, Lacal JC, Robine S, Nasioulas G, Andera L. Sensitization of (colon) cancer cells to death receptor related therapies: a report from the FP6-ONCODEATH research consortium. Cancer Biology & Therapy. 13: 458-66. PMID 22406997 DOI: 10.4161/Cbt.19600  0.099
2019 Sharifnia T, Wawer MJ, Chen T, Huang QY, Weir BA, Sizemore A, Lawlor MA, Goodale A, Cowley GS, Vazquez F, Ott CJ, Francis JM, Sassi S, Cogswell P, Sheppard HE, ... ... Clarke PA, et al. Small-molecule targeting of brachyury transcription factor addiction in chordoma. Nature Medicine. PMID 30664779 DOI: 10.1038/S41591-018-0312-3  0.099
2021 Antolin AA, Clarke PA, Collins I, Workman P, Al-Lazikani B. Evolution of kinase polypharmacology across HSP90 drug discovery. Cell Chemical Biology. PMID 34077750 DOI: 10.1016/j.chembiol.2021.05.004  0.099
2014 Keogh D, Thompson R, Larragy R, McMahon K, O'Connell M, O'Connor B, Clarke P. Generating novel recombinant prokaryotic lectins with altered carbohydrate binding properties through mutagenesis of the PA-IL protein from Pseudomonas aeruginosa. Biochimica Et Biophysica Acta. 1840: 2091-104. PMID 24462641 DOI: 10.1016/J.Bbagen.2014.01.020  0.099
2016 Workman P, Clarke P. PI3 Kinase in Cancer: From Biology to Clinic. American Society of Clinical Oncology Educational Book. American Society of Clinical Oncology. Annual Meeting. e93-8. PMID 24451841 DOI: 10.14694/EdBook_AM.2012.32.89  0.096
2019 Calpena E, Hervieu A, Kaserer T, Swagemakers SMA, Goos JAC, Popoola O, Ortiz-Ruiz MJ, Barbaro-Dieber T, Bownass L, Brilstra EH, Brimble E, Foulds N, Grebe TA, Harder AVE, Lees MM, ... ... Clarke PA, et al. De Novo Missense Substitutions in the Gene Encoding CDK8, a Regulator of the Mediator Complex, Cause a Syndromic Developmental Disorder. American Journal of Human Genetics. PMID 30905399 DOI: 10.1016/J.Ajhg.2019.02.006  0.096
2004 Harris JC, Gilliam AD, McKenzie AJ, Evans SA, Grabowska AM, Clarke PA, McWilliams DF, Watson SA. The biological and therapeutic importance of gastrin gene expression in pancreatic adenocarcinomas. Cancer Research. 64: 5624-31. PMID 15313900 DOI: 10.1158/0008-5472.CAN-04-0106  0.096
2017 Chessum NEA, Sharp SY, Caldwell JJ, Pasqua AE, Wilding B, Colombano G, Collins I, Ozer B, Richards M, Rowlands MG, Stubbs M, Burke R, McAndrew PC, Clarke PA, Workman P, et al. Demonstrating In-Cell Target Engagement using a Pirin Protein Degradation Probe (CCT367766). Journal of Medicinal Chemistry. PMID 29240418 DOI: 10.1021/Acs.Jmedchem.7B01406  0.095
2008 Powers MV, Clarke PA, Workman P. Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosis. Cancer Cell. 14: 250-62. PMID 18772114 DOI: 10.1016/j.ccr.2008.08.002  0.095
2017 Dolly SO, Gurden MD, Drosopoulos K, Clarke P, de Bono J, Kaye S, Workman P, Linardopoulos S. RNAi screen reveals synthetic lethality between cyclin G-associated kinase and FBXW7 by inducing aberrant mitoses. British Journal of Cancer. PMID 28829765 DOI: 10.1038/bjc.2017.277  0.094
2016 Workman P, Clarke PA, Al-Lazikani B. Blocking the survival of the nastiest by HSP90 inhibition. Oncotarget. 7: 3658-61. PMID 26820296 DOI: 10.18632/oncotarget.6971  0.093
2017 Al-Saffar NMS, Agliano A, Marshall LV, Jackson LE, Balarajah G, Sidhu J, Clarke PA, Jones C, Workman P, Pearson ADJ, Leach MO. In vitro nuclear magnetic resonance spectroscopy metabolic biomarkers for the combination of temozolomide with PI3K inhibition in paediatric glioblastoma cells. Plos One. 12: e0180263. PMID 28704425 DOI: 10.1371/journal.pone.0180263  0.091
2003 Clarke PA, Arnold PL, Smith MA, Natrajan LS, Wilson C, Chan C. Mechanistic insight into the lanthanide (III) salt catalysed monoacylation of symmetrical diols from structural models Chemical Communications. 9: 2588-2589.  0.09
2017 Sweet DG, Turner M, Straňák Z, Plavka R, Clarke P, Stenson B, Singer D, Goelz R, Fabbri L, Varoli G, Piccinno A, Santoro D, Speer CP. A first-in-human clinical study of a new SP-B and SP-C enriched synthetic surfactant (CHF5633) in preterm babies with respiratory distress syndrome. Archives of Disease in Childhood. Fetal and Neonatal Edition. PMID 28465315 DOI: 10.1136/archdischild-2017-312722  0.089
2014 Cook KL, Clarke PA, Parmar J, Hu R, Schwartz-Roberts JL, Abu-Asab M, Wärri A, Baumann WT, Clarke R. Knockdown of estrogen receptor-α induces autophagy and inhibits antiestrogen-mediated unfolded protein response activation, promoting ROS-induced breast cancer cell death. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 3891-905. PMID 24858277 DOI: 10.1096/Fj.13-247353  0.089
2003 Aherne W, Maloney A, Prodromou C, Rowlands MG, Hardcastle A, Boxall K, Clarke P, Walton MI, Pearl L, Workman P. Assays for HSP90 and inhibitors. Methods in Molecular Medicine. 85: 149-61. PMID 12710206 DOI: 10.1385/1-59259-380-1:149  0.088
2012 Hewson CA, Patel S, Calzetta L, Campwala H, Havard S, Luscombe E, Clarke PA, Peachell PT, Matera MG, Cazzola M, Page C, Abraham WM, Williams CM, Clark JD, Liu WL, et al. Preclinical evaluation of an inhibitor of cytosolic phospholipase A2α for the treatment of asthma. The Journal of Pharmacology and Experimental Therapeutics. 340: 656-65. PMID 22160268 DOI: 10.1124/Jpet.111.186379  0.088
2001 Kelland LR, Smith V, Valenti M, Patterson L, Clarke PA, Detre S, End D, Howes AJ, Dowsett M, Workman P, Johnston SR. Preclinical antitumor activity and pharmacodynamic studies with the farnesyl protein transferase inhibitor R115777 in human breast cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 7: 3544-50. PMID 11705875  0.086
2001 Clarke PA, te Poele R, Wooster R, Workman P. Gene expression microarray analysis in cancer biology, pharmacology, and drug development: progress and potential. Biochemical Pharmacology. 62: 1311-36. PMID 11709192 DOI: 10.1016/S0006-2952(01)00785-7  0.086
2004 Clarke PA, te Poele R, Workman P. Gene expression microarray technologies in the development of new therapeutic agents. European Journal of Cancer (Oxford, England : 1990). 40: 2560-91. PMID 15541959 DOI: 10.1016/j.ejca.2004.07.024  0.086
2006 Savage K, Waller HA, Stubbs M, Khan K, Watson SA, Clarke PA, Grimes S, Michaeli D, Dhillon AP, Caplin ME. Targeting of cholecystokinin B/gastrin receptor in colonic, pancreatic and hepatocellular carcinoma cell lines. International Journal of Oncology. 29: 1429-35. PMID 17088981  0.079
2017 Agliano A, Balarajah G, Ciobota DM, Sidhu J, Clarke PA, Jones C, Workman P, Leach MO, Al-Saffar NMS. Pediatric and adult glioblastoma radiosensitization induced by PI3K/mTOR inhibition causes early metabolic alterations detected by nuclear magnetic resonance spectroscopy. Oncotarget. PMID 28624789 DOI: 10.18632/oncotarget.18206  0.079
2002 Panaretou B, Siligardi G, Meyer P, Maloney A, Sullivan JK, Singh S, Millson SH, Clarke PA, Naaby-Hansen S, Stein R, Cramer R, Mollapour M, Workman P, Piper PW, Pearl LH, et al. Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1. Molecular Cell. 10: 1307-18. PMID 12504007 DOI: 10.1016/S1097-2765(02)00785-2  0.078
2020 Sweet DG, Turner M, Straňák Z, Plavka R, Clarke P, Stenson B, Singer D, Goelz R, Fabbri L, Varoli G, Piccinno A, Santoro D, Del Buono D, Speer CP. A first-in-human clinical study of a new SP-B and SP-C enriched synthetic surfactant (CHF5633) in preterm babies with respiratory distress syndrome: two-year outcomes. The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 1-5. PMID 33345663 DOI: 10.1080/14767058.2020.1863363  0.078
2015 Yap TA, Bjerke L, Clarke PA, Workman P. Drugging PI3K in cancer: refining targets and therapeutic strategies. Current Opinion in Pharmacology. 23: 98-107. PMID 26117819 DOI: 10.1016/j.coph.2015.05.016  0.077
2015 Yap TA, Bjerke L, Clarke PA, Workman P. Drugging PI3K in cancer: Refining targets and therapeutic strategies Current Opinion in Pharmacology. 23: 98-107. DOI: 10.1016/j.coph.2015.05.016  0.077
2012 Clarke PA, Workman P. Phosphatidylinositide-3-kinase inhibitors: addressing questions of isoform selectivity and pharmacodynamic/predictive biomarkers in early clinical trials. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 30: 331-3. PMID 22162582 DOI: 10.1200/JCO.2011.38.7167  0.076
2004 Harris JC, Clarke PA, Awan A, Jankowski J, Watson SA. An antiapoptotic role for gastrin and the gastrin/CCK-2 receptor in Barrett's esophagus. Cancer Research. 64: 1915-9. PMID 15026323 DOI: 10.1158/0008-5472.CAN-03-2713  0.076
2012 Carden CP, Stewart A, Thavasu P, Kipps E, Pope L, Crespo M, Miranda S, Attard G, Garrett MD, Clarke PA, Workman P, de Bono JS, Gore M, Kaye SB, Banerji U. The association of PI3 kinase signaling and chemoresistance in advanced ovarian cancer. Molecular Cancer Therapeutics. 11: 1609-17. PMID 22556379 DOI: 10.1158/1535-7163.MCT-11-0996  0.075
2004 Clarke PA, Pestell KE, Di Stefano F, Workman P, Walton MI. Characterisation of molecular events following cisplatin treatment of two curable ovarian cancer models: contrasting role for p53 induction and apoptosis in vivo. British Journal of Cancer. 91: 1614-23. PMID 15452549 DOI: 10.1038/sj.bjc.6602167  0.075
2015 Sarker D, Ang JE, Baird R, Kristeleit R, Shah K, Moreno V, Clarke PA, Raynaud FI, Levy G, Ware JA, Mazina K, Lin R, Wu J, Fredrickson J, Spoerke JM, et al. First-in-human phase I study of pictilisib (GDC-0941), a potent pan-class I phosphatidylinositol-3-kinase (PI3K) inhibitor, in patients with advanced solid tumors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 77-86. PMID 25370471 DOI: 10.1158/1078-0432.CCR-14-0947  0.075
2013 Gonzalez de Castro D, Clarke PA, Al-Lazikani B, Workman P. Personalized cancer medicine: molecular diagnostics, predictive biomarkers, and drug resistance. Clinical Pharmacology and Therapeutics. 93: 252-9. PMID 23361103 DOI: 10.1038/clpt.2012.237  0.075
2018 Vlachogiannis G, Hedayat S, Vatsiou A, Jamin Y, Fernández-Mateos J, Khan K, Lampis A, Eason K, Huntingford I, Burke R, Rata M, Koh DM, Tunariu N, Collins D, Hulkki-Wilson S, ... ... Clarke PA, et al. Patient-derived organoids model treatment response of metastatic gastrointestinal cancers. Science (New York, N.Y.). 359: 920-926. PMID 29472484 DOI: 10.1126/science.aao2774  0.075
2004 Cuív PO, Clarke P, Lynch D, O'Connell M. Identification of rhtX and fptX, novel genes encoding proteins that show homology and function in the utilization of the siderophores rhizobactin 1021 by Sinorhizobium meliloti and pyochelin by Pseudomonas aeruginosa, respectively. Journal of Bacteriology. 186: 2996-3005. PMID 15126460 DOI: 10.1128/JB.186.10.2996-3005.2004  0.073
2005 Clarke P, Cuív PO, O'Connell M. Novel mobilizable prokaryotic two-hybrid system vectors for high-throughput protein interaction mapping in Escherichia coli by bacterial conjugation. Nucleic Acids Research. 33: e18. PMID 15687376 DOI: 10.1093/nar/gni011  0.073
2001 Ross PJ, George M, Cunningham D, DiStefano F, Andreyev HJ, Workman P, Clarke PA. Inhibition of Kirsten-ras expression in human colorectal cancer using rationally selected Kirsten-ras antisense oligonucleotides. Molecular Cancer Therapeutics. 1: 29-41. PMID 12467236  0.073
2013 Cook KL, Clarke PA, Clarke R. Targeting GRP78 and antiestrogen resistance in breast cancer. Future Medicinal Chemistry. 5: 1047-57. PMID 23734687 DOI: 10.4155/Fmc.13.77  0.072
2020 Zhang C, Stockwell SR, Elbanna M, Ketteler R, Freeman J, Al-Lazikani B, Eccles S, De Haven Brandon A, Raynaud F, Hayes A, Clarke PA, Workman P, Mittnacht S. Correction: Signalling involving MET and FAK supports cell division independent of the activity of the cell cycle-regulating CDK4/6 kinases. Oncogene. PMID 32094403 DOI: 10.1038/s41388-020-1221-8  0.072
2008 Clarke PA, Powers M, Workman P. Inhibition of the Molecular Chaperone Heat Shock Protein 90 in Cancer: Consequences for the Regulation of Survival Signaling and Induction of Cell Death Apoptosis and Cancer Therapy: From Cutting-Edge Science to Novel Therapeutic Concepts. 2: 933-965. DOI: 10.1002/9783527619665.ch37  0.071
1998 Watson SA, Michael D, Justin TA, Grimes S, Morris TM, Robinson G, Clarke PA, Hardcastle JD. Pre-clinical evaluation of the Gastrimmune immunogen alone and in combination with 5-fluorouracil/leucovorin in a rat colorectal cancer model. International Journal of Cancer. Journal International Du Cancer. 75: 873-7. PMID 9506532 DOI: 10.1002/(SICI)1097-0215(19980316)75:6<873::AID-IJC9>3.0.CO;2-S  0.071
2013 Parmar JH, Cook KL, Shajahan-Haq AN, Clarke PA, Tavassoly I, Clarke R, Tyson JJ, Baumann WT. Modelling the effect of GRP78 on anti-oestrogen sensitivity and resistance in breast cancer. Interface Focus. 3: 20130012. PMID 24511377 DOI: 10.1098/Rsfs.2013.0012  0.068
2006 Cuív PÓ, Clarke P, O'Connell M. Identification and characterization of an iron-regulated gene, chtA, required for the utilization of the xenosiderophores aerobactin, rhizobactin 1021 and schizokinen by Pseudomonas aeruginosa. Microbiology (Reading, England). 152: 945-954. PMID 16549659 DOI: 10.1099/mic.0.28552-0  0.068
1999 Ronen SM, DiStefano F, McCoy CL, Robertson D, Smith TA, Al-Saffar NM, Titley J, Cunningham DC, Griffiths JR, Leach MO, Clarke PA. Magnetic resonance detects metabolic changes associated with chemotherapy-induced apoptosis. British Journal of Cancer. 80: 1035-41. PMID 10362112 DOI: 10.1038/sj.bjc.6690459  0.067
2000 Watson SA, Clarke PA, Morris TM, Caplin ME. Antiserum raised against an epitope of the cholecystokinin B/gastrin receptor inhibits hepatic invasion of a human colon tumor. Cancer Research. 60: 5902-7. PMID 11059789  0.066
2021 Ponnusamy V, Ip RTH, Mohamed MAEK, Clarke P, Wozniak E, Mein C, Schwendimann L, Barlas A, Chisholm P, Chakkarapani E, Michael-Titus AT, Gressens P, Yip PK, Shah DK. Neuronal let-7b-5p acts through the Hippo-YAP pathway in neonatal encephalopathy. Communications Biology. 4: 1143. PMID 34593980 DOI: 10.1038/s42003-021-02672-3  0.066
2017 Lampis A, Carotenuto P, Vlachogiannis G, Cascione L, Hedayat S, Burke R, Clarke P, Bosma E, Simbolo M, Scarpa A, Yu S, Cole R, Smyth E, Mateos JF, Begum R, et al. MIR21 drives resistance to Heat Shock Protein 90 inhibition in cholangiocarcinoma. Gastroenterology. PMID 29113809 DOI: 10.1053/J.Gastro.2017.10.043  0.065
1997 Circle DA, Neel OD, Robertson HD, Clarke PA, Mathews MB. Surprising specificity of PKR binding to delta agent genomic RNA Rna. 3: 438-448. PMID 9085850  0.065
2015 Lally PJ, Pauliah S, Montaldo P, Chaban B, Oliveira V, Bainbridge A, Soe A, Pattnayak S, Clarke P, Satodia P, Harigopal S, Abernethy LJ, Turner MA, Huertas-Ceballos A, Shankaran S, et al. Magnetic Resonance Biomarkers in Neonatal Encephalopathy (MARBLE): a prospective multicountry study. Bmj Open. 5: e008912. PMID 26423856 DOI: 10.1136/bmjopen-2015-008912  0.065
2009 Cuív PO, Keogh D, Clarke P, O'Connell M. The hmuUV genes of Sinorhizobium meliloti 2011 encode the permease and ATPase components of an ABC transport system for the utilization of both haem and the hydroxamate siderophores, ferrichrome and ferrioxamine B. Molecular Microbiology. 70: 1261-73. PMID 18990190 DOI: 10.1111/j.1365-2958.2008.06479.x  0.064
2014 Cook KL, Wärri A, Soto-Pantoja DR, Clarke PA, Cruz MI, Zwart A, Clarke R. Hydroxychloroquine inhibits autophagy to potentiate antiestrogen responsiveness in ER+ breast cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 3222-32. PMID 24928945 DOI: 10.1158/1078-0432.Ccr-13-3227  0.064
2018 Bright MD, Clarke PA, Workman P, Davies FE. Oncogenic RAC1 and NRAS drive resistance to endoplasmic reticulum stress through MEK/ERK signalling. Cellular Signalling. PMID 29329780 DOI: 10.1016/j.cellsig.2018.01.004  0.063
2011 Alwael H, Connolly D, Clarke P, Thompson R, Twamley B, O'Connor B, Paull B. Pipette-tip selective extraction of glycoproteins with lectin modified gold nano-particles on a polymer monolithic phase. The Analyst. 136: 2619-28. PMID 21552581 DOI: 10.1039/C1An15137A  0.063
2019 Carotenuto P, Hedayat S, Fassan M, Cardinale V, Lampis A, Guzzardo V, Vicentini C, Scarpa A, Cascione L, Costantini D, Carpino G, Alvaro D, Ghidini M, Trevisani F, Te Poele R, ... ... Clarke P, et al. Modulation of biliary cancer chemo-resistance through microRNA-mediated rewiring of the expansion of CD133+ cells. Hepatology (Baltimore, Md.). PMID 31879968 DOI: 10.1002/hep.31094  0.063
1997 Webb A, Cunningham D, Cotter F, Clarke PA, Di Stefano F, Ross P, Corbo M, Dziewanowska Z. BCL-2 antisense therapy in patients with non-Hodgkin lymphoma Lancet. 349: 1137-1141. PMID 9113013 DOI: 10.1016/S0140-6736(96)11103-X  0.062
1999 Clarke PA. Labeling and purification of RNA synthesized by in vitro transcription. Methods in Molecular Biology (Clifton, N.J.). 118: 1-10. PMID 10549510 DOI: 10.1385/1-59259-676-2:1  0.061
1999 Watson SA, Michaeli D, Grimes S, Morris TM, Varro A, Clarke PA, Smith AM, Justin TA, Hardcastle JD. A comparison of an anti-gastrin antibody and cytotoxic drugs in the therapy of human gastric ascites in SCID mice. International Journal of Cancer. Journal International Du Cancer. 81: 248-54. PMID 10188727 DOI: 10.1002/(SICI)1097-0215(19990412)81:2<248::AID-IJC14>3.0.CO;2-G  0.061
2017 Kiu R, Caim S, Alcon-Giner C, Belteki G, Clarke P, Pickard D, Dougan G, Hall LJ. Preterm Infant-Associated Clostridium tertium, Clostridium cadaveris, and Clostridium paraputrificum Strains: Genomic and Evolutionary Insights. Genome Biology and Evolution. 9: 2707-2714. PMID 29044436 DOI: 10.1093/gbe/evx210  0.061
2003 Rogers MA, Clarke P, Noble J, Munro NP, Paul A, Selby PJ, Banks RE. Proteomic profiling of urinary proteins in renal cancer by surface enhanced laser desorption ionization and neural-network analysis: identification of key issues affecting potential clinical utility. Cancer Research. 63: 6971-83. PMID 14583499  0.059
2006 Clarke PA, Dickson JH, Harris JC, Grabowska A, Watson SA. Gastrin enhances the angiogenic potential of endothelial cells via modulation of heparin-binding epidermal-like growth factor. Cancer Research. 66: 3504-12. PMID 16585174 DOI: 10.1158/0008-5472.CAN-05-0280  0.059
1999 Zobel AM, Clarke PA. Production of phenolics in seedlings of Acer saccharum and Acer platanoides in response to UV-A irradiation and heavy metals Allelopathy Journal. 6: 21-34.  0.058
2015 Pert PL, Ens EJ, Locke J, Clarke PA, Packer JM, Turpin G. An online spatial database of Australian Indigenous Biocultural Knowledge for contemporary natural and cultural resource management. The Science of the Total Environment. PMID 25682266 DOI: 10.1016/j.scitotenv.2015.01.073  0.057
2001 Andreyev HJ, Norman AR, Cunningham D, Oates J, Dix BR, Iacopetta BJ, Young J, Walsh T, Ward R, Hawkins N, Beranek M, Jandik P, Benamouzig R, Jullian E, Laurent-Puig P, ... ... Clarke PA, et al. Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study. British Journal of Cancer. 85: 692-6. PMID 11531254 DOI: 10.1054/bjoc.2001.1964  0.057
2013 de Billy E, Clarke PA, Workman P. HSF1 in Translation. Cancer Cell. 24: 147-9. PMID 23948296 DOI: 10.1016/j.ccr.2013.07.017  0.057
2002 Al-Saffar NM, Titley JC, Robertson D, Clarke PA, Jackson LE, Leach MO, Ronen SM. Apoptosis is associated with triacylglycerol accumulation in Jurkat T-cells. British Journal of Cancer. 86: 963-70. PMID 11953830 DOI: 10.1038/sj.bjc.6600188  0.056
1997 Crews C, Startin JR, Clarke PA. Determination of pyrrolizidine alkaloids in honey from selected sites by solid phase extraction and HPLC-MS Food Additives and Contaminants. 14: 419-428. PMID 9328525  0.055
2006 Cuív PO, Keogh D, Clarke P, O'Connell M. FoxB of Pseudomonas aeruginosa functions in the utilization of the xenosiderophores ferrichrome, ferrioxamine B, and schizokinen: evidence for transport redundancy at the inner membrane. Journal of Bacteriology. 189: 284-7. PMID 17056746 DOI: 10.1128/JB.01142-06  0.055
1998 Parsons SL, Watson SA, Collins HM, Griffin NR, Clarke PA, Steele RJC. Gelatinase (MMP-2 and -9) expression in gastrointestinal malignancy British Journal of Cancer. 78: 1495-1502. PMID 9836483  0.055
2021 Horvat P, Gray CM, Lambova A, Christian JB, Lasiter L, Stewart M, Allen J, Clarke P, Chen C, Reich A. Comparing Findings From a Friends of Cancer Research Exploratory Analysis of Real-World End Points With the Cancer Analysis System in England. Jco Clinical Cancer Informatics. 5: 1155-1168. PMID 34860576 DOI: 10.1200/CCI.21.00013  0.054
2006 Clarke P, Robinson MJ, Ahmad I, Bedford-Russell AR, Connell JE, Powell PJ, Heath PT. Response of steroid-treated former preterm infants to a single dose of meningococcal C conjugate vaccine. Vaccine. 24: 3273-8. PMID 16472548 DOI: 10.1016/j.vaccine.2006.01.027  0.054
2018 Heathcote AC, Jones J, Clarke P. Timing and documentation of key events in neonatal resuscitation. European Journal of Pediatrics. PMID 29713811 DOI: 10.1007/s00431-018-3160-8  0.054
2016 Ravida A, Cwiklinski K, Aldridge AM, Clarke P, Thompson R, Gerlach JQ, Kilcoyne M, Hokke CH, Dalton JP, O'Neill SM. Fasciola hepatica surface tegument: glycoproteins at the interface of parasite and host. Molecular & Cellular Proteomics : McP. PMID 27466253 DOI: 10.1074/mcp.M116.059774  0.054
2001 Workman P, Clarke PA. Innovative cancer drug targets: genomics, transcriptomics and clinomics. Expert Opinion On Pharmacotherapy. 2: 911-5. PMID 11585007 DOI: 10.1517/14656566.2.6.911  0.053
2014 Smith SJ, Rahman CV, Clarke PA, Ritchie AA, Gould TW, Ward JH, Shakesheff KM, Grundy RG, Rahman R. Surgical delivery of drug releasing poly(lactic-co-glycolic acid)/poly(ethylene glycol) paste with in vivo effects against glioblastoma. Annals of the Royal College of Surgeons of England. 96: 495-501. PMID 25245726 DOI: 10.1308/003588414X13946184903568  0.053
2003 Clarke P, Sproston K, Thomas R. An investigation into expectation-led interviewer effects in health surveys. Social Science & Medicine (1982). 56: 2221-8. PMID 12697210 DOI: 10.1016/S0277-9536(02)00238-1  0.053
1997 Schneider HJ, Sampson SA, Cunningham D, Norman AR, Andreyev HJN, Tilsed JVT, Clarke PA. Bcl-2 expression and response to chemotherapy in colorectal adenocarcinomas British Journal of Cancer. 75: 427-431. PMID 9020491 DOI: 10.1038/bjc.1997.70  0.053
2011 Rao S, Welsh L, Cunningham D, te-Poele RH, Benson M, Norman A, Saffery C, Giddings I, Workman P, Clarke PA. Correlation of overall survival with gene expression profiles in a prospective study of resectable esophageal cancer. Clinical Colorectal Cancer. 10: 48-56. PMID 21609936 DOI: 10.3816/CCC.2011.n.007  0.052
2019 Chong C, van Druten J, Briars G, Eaton S, Clarke P, Tsang T, Yardley I. Neonates living with enterostomy following necrotising enterocolitis are at high risk of becoming severely underweight. European Journal of Pediatrics. PMID 31522315 DOI: 10.1007/s00431-019-03440-6  0.052
1998 Watson SA, Clarke PA, Smith AM, Varro A, Michaeli D, Grimes S, Caplin M, Hardcastle JD. Expression of CCKB/gastrin receptor isoforms in gastro-intestinal tumour cells International Journal of Cancer. 77: 572-577. PMID 9679761 DOI: 10.1002/(SICI)1097-0215(19980812)77:4<572::AID-IJC17>3.0.CO;2-8  0.051
2018 Shah DK, Ponnusamy V, Evanson J, Kapellou O, Ekitzidou G, Gupta N, Clarke P, Michael-Titus AT, Yip PK. Raised Plasma Neurofilament Light Protein Levels Are Associated with Abnormal MRI Outcomes in Newborns Undergoing Therapeutic Hypothermia. Frontiers in Neurology. 9: 86. PMID 29556208 DOI: 10.3389/fneur.2018.00086  0.05
1999 More DG, Clarke PA. The General Practice computer system project: a doctor's desktop for Australia. International Journal of Medical Informatics. 55: 65-75. PMID 10471242 DOI: 10.1016/S1386-5056(99)00021-0  0.05
2009 Cook TM, Gatward JJ, Handel J, Hardy R, Thompson C, Srivastava R, Clarke PA. Evaluation of the LMA Supreme in 100 non-paralysed patients. Anaesthesia. 64: 555-62. PMID 19413827 DOI: 10.1111/j.1365-2044.2008.05824.x  0.05
2015 Chua JX, Vankemmelbeke M, McIntosh RS, Clarke PA, Moss R, Parsons T, Spendlove I, Zaitoun AM, Madhusudan S, Durrant LG. Monoclonal Antibodies Targeting LecLex-Related Glycans with Potent Antitumor Activity. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 2963-74. PMID 25779947 DOI: 10.1158/1078-0432.CCR-14-3030  0.049
2013 Rahman CV, Smith SJ, Morgan PS, Langmack KA, Clarke PA, Ritchie AA, Macarthur DC, Rose FR, Shakesheff KM, Grundy RG, Ruman Rahman. Adjuvant chemotherapy for brain tumors delivered via a novel intra-cavity moldable polymer matrix. Plos One. 8: e77435. PMID 24155955 DOI: 10.1371/journal.pone.0077435  0.049
2008 Mozdzer TJ, Hutto CJ, Clarke PA, Field DP. Efficacy of imazapyr and glyphosate in the control of non-native Phragmites australis Restoration Ecology. 16: 221-224. DOI: 10.1111/J.1526-100X.2008.00386.X  0.049
2007 El-Zaatari M, Tobias A, Grabowska AM, Kumari R, Scotting PJ, Kaye P, Atherton J, Clarke PA, Powe DG, Watson SA. De-regulation of the sonic hedgehog pathway in the InsGas mouse model of gastric carcinogenesis. British Journal of Cancer. 96: 1855-61. PMID 17505514 DOI: 10.1038/sj.bjc.6603782  0.049
2017 Mulla S, Stirling S, Cowey S, Close R, Pullan S, Howe R, Radbone L, Clarke P. Severe hypercalcaemia and hypophosphataemia with an optimised preterm parenteral nutrition formulation in two epochs of differing phosphate supplementation. Archives of Disease in Childhood. Fetal and Neonatal Edition. PMID 28456753 DOI: 10.1136/archdischild-2016-311107  0.049
2012 Wijeyesekera A, Clarke PA, Bictash M, Brown IJ, Fidock M, Ryckmans T, Yap IK, Chan Q, Stamler J, Elliott P, Holmes E, Nicholson JK. Quantitative UPLC-MS/MS analysis of the gut microbial co-metabolites phenylacetylglutamine, 4-cresyl sulphate and hippurate in human urine: INTERMAP Study. Analytical Methods : Advancing Methods and Applications. 4: 65-72. PMID 23946767 DOI: 10.1039/C1AY05427A  0.048
2002 Watson SA, Morris TM, McWilliams DF, Harris J, Evans S, Smith A, Clarke PA. Potential role of endocrine gastrin in the colonic adenoma carcinoma sequence. British Journal of Cancer. 87: 567-73. PMID 12189558 DOI: 10.1038/sj.bjc.6600509  0.047
2020 Alcon-Giner C, Dalby MJ, Caim S, Ketskemety J, Shaw A, Sim K, Lawson MAE, Kiu R, Leclaire C, Chalklen L, Kujawska M, Mitra S, Fardus-Reid F, Belteki G, McColl K, ... ... Clarke P, et al. Microbiota Supplementation with and Modifies the Preterm Infant Gut Microbiota and Metabolome: An Observational Study. Cell Reports. Medicine. 1: 100077. PMID 32904427 DOI: 10.1016/j.xcrm.2020.100077  0.046
2017 Clarke P. Family-centred care right from birth: the irreplaceable birthday cuddle. Acta Paediatrica (Oslo, Norway : 1992). PMID 28608944 DOI: 10.1111/apa.13946  0.046
2006 Munro NP, Cairns DA, Clarke P, Rogers M, Stanley AJ, Barrett JH, Harnden P, Thompson D, Eardley I, Banks RE, Knowles MA. Urinary biomarker profiling in transitional cell carcinoma. International Journal of Cancer. Journal International Du Cancer. 119: 2642-50. PMID 16991122 DOI: 10.1002/ijc.22238  0.046
2010 Pai JR, Tremlett CH, Clarke P. Late-onset sepsis in a preterm twin may harbinger life-threatening sepsis for the asymptomatic co-twin. The Pediatric Infectious Disease Journal. 29: 381-2. PMID 19934788 DOI: 10.1097/INF.0b013e3181c42545  0.045
2013 Battineni S, Clarke P. Green teeth are a late complication of prolonged conjugated hyperbilirubinemia in extremely low birth weight infants. Pediatric Dentistry. 34: 103-6. PMID 23014082  0.045
2009 Chaudhary R, Chonat S, Gowda H, Clarke P, Curley A. Use of premedication for intubation in tertiary neonatal units in the United Kingdom. Paediatric Anaesthesia. 19: 653-8. PMID 19490437 DOI: 10.1111/j.1460-9592.2008.02829.x  0.044
2005 Viguier C, O Cuív P, Clarke P, O'Connell M. RirA is the iron response regulator of the rhizobactin 1021 biosynthesis and transport genes in Sinorhizobium meliloti 2011. Fems Microbiology Letters. 246: 235-42. PMID 15899411 DOI: 10.1016/j.femsle.2005.04.012  0.044
2019 Clarke P, Craig JV, Wain J, Tremlett C, Linsell L, Bowler U, Juszczak E, Heath PT. Safety and efficacy of 2% chlorhexidine gluconate aqueous versus 2% chlorhexidine gluconate in 70% isopropyl alcohol for skin disinfection prior to percutaneous central venous catheter insertion in preterm neonates: the ARCTIC randomised-controlled feasibility trial protocol. Bmj Open. 9: e028022. PMID 30782955 DOI: 10.1136/bmjopen-2018-028022  0.044
2003 Clarke P, Iqbal M, Mitchell S. A comparison of transient-evoked otoacoustic emissions and automated auditory brainstem responses for pre-discharge neonatal hearing screening. International Journal of Audiology. 42: 443-7. PMID 14658852  0.044
2010 Harrington DJ, Clarke P, Card DJ, Mitchell SJ, Shearer MJ. Urinary excretion of vitamin K metabolites in term and preterm infants: relationship to vitamin K status and prophylaxis. Pediatric Research. 68: 508-12. PMID 20814348 DOI: 10.1203/PDR.0b013e3181f981c7  0.043
2016 Kalra V, Shaw SS, Dixon S, Shah DK, Clarke P. Cerebral function monitoring on a general paediatric ward: feasibility and potential. European Journal of Pediatrics. PMID 27271341 DOI: 10.1007/s00431-016-2737-3  0.041
2009 Baird RD, Kitzen J, Clarke PA, Planting A, Reade S, Reid A, Welsh L, López Lázaro L, de las Heras B, Judson IR, Kaye SB, Eskens F, Workman P, deBono JS, Verweij J. Phase I safety, pharmacokinetic, and pharmacogenomic trial of ES-285, a novel marine cytotoxic agent, administered to adult patients with advanced solid tumors. Molecular Cancer Therapeutics. 8: 1430-7. PMID 19509256 DOI: 10.1158/1535-7163.MCT-08-1167  0.041
2000 Waters JS, Webb A, Cunningham D, Clarke PA, Raynaud F, di Stefano F, Cotter FE. Phase I clinical and pharmacokinetic study of bcl-2 antisense oligonucleotide therapy in patients with non-Hodgkin's lymphoma. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 18: 1812-23. PMID 10784621  0.041
2019 Leggett RM, Alcon-Giner C, Heavens D, Caim S, Brook TC, Kujawska M, Martin S, Peel N, Acford-Palmer H, Hoyles L, Clarke P, Hall LJ, Clark MD. Rapid MinION profiling of preterm microbiota and antimicrobial-resistant pathogens. Nature Microbiology. PMID 31844297 DOI: 10.1038/s41564-019-0626-z  0.041
2020 Chen Y, Brook TC, Soe CZ, O'Neill I, Alcon-Giner C, Leelastwattanagul O, Phillips S, Caim S, Clarke P, Hall LJ, Hoyles L. Preterm infants harbour diverse populations, including atypical species that encode and produce an array of antimicrobial resistance- and virulence-associated factors. Microbial Genomics. PMID 32436839 DOI: 10.1099/mgen.0.000377  0.04
2007 Garske T, Ward HJ, Clarke P, Will RG, Ghani AC. Factors determining the potential for onward transmission of variant Creutzfeldt-Jakob disease via surgical instruments. Journal of the Royal Society, Interface. 3: 757-66. PMID 17015298 DOI: 10.1098/rsif.2006.0142  0.04
2022 Notley C, Brown TJ, Bauld L, Boyle EM, Clarke P, Hardeman W, Holland R, Hubbard M, Naughton F, Nichols A, Orton S, Ussher M, Ward E. Development of a Smoke-Free Home Intervention for Families of Babies Admitted to Neonatal Intensive Care. International Journal of Environmental Research and Public Health. 19. PMID 35329355 DOI: 10.3390/ijerph19063670  0.04
2013 Venkatesh V, Curley A, Khan R, Clarke P, Watts T, Josephson C, Muthukumar P, New H, Seeney F, Morris S, Stanworth S. A novel approach to standardised recording of bleeding in a high risk neonatal population. Archives of Disease in Childhood. Fetal and Neonatal Edition. 98: F260-263. PMID 23144007 DOI: 10.1136/archdischild-2012-302443  0.04
2008 Jones AD, Sendt JS, Duncan AJ, Clarke PA, Zhang Z, Vu H. Comparison of sonar transmission models at mid‐frequency for synthetic and real environments The Journal of the Acoustical Society of America. 123: 3434-3434. DOI: 10.1121/1.2934215  0.039
2017 Alcon-Giner C, Caim S, Mitra S, Ketskemety J, Wegmann U, Wain J, Belteki G, Clarke P, Hall LJ. Optimisation of 16S rRNA gut microbiota profiling of extremely low birth weight infants. Bmc Genomics. 18: 841. PMID 29096601 DOI: 10.1186/s12864-017-4229-x  0.038
2011 Workman P, Clarke PA. Resisting targeted therapy: fifty ways to leave your EGFR. Cancer Cell. 19: 437-40. PMID 21481786 DOI: 10.1016/j.ccr.2011.03.020  0.037
2018 Kent A, Beebeejaun K, Braccio S, Kadambari S, Clarke P, Heath PT, Ladhani S. Safety of meningococcal group B vaccination in hospitalised premature infants. Archives of Disease in Childhood. Fetal and Neonatal Edition. PMID 29636385 DOI: 10.1136/archdischild-2017-314152  0.037
2013 Austin T, Shanmugalingam S, Clarke P. To cool or not to cool? Hypothermia treatment outside trial criteria. Archives of Disease in Childhood. Fetal and Neonatal Edition. 98: F451-3. PMID 22820487 DOI: 10.1136/Archdischild-2012-302069  0.036
2011 Zhang Y, Zhang G, Clarke PA, Huang JT, Takahashi E, Muirhead D, Steenwyk RC, Lin Z. Simultaneous and high-throughput quantitation of urinary tetranor PGDM and tetranor PGEM by online SPE-LC-MS/MS as inflammatory biomarkers. Journal of Mass Spectrometry : Jms. 46: 705-11. PMID 21706677 DOI: 10.1002/jms.1941  0.036
2011 Bose J, Clarke P. Use of tissue plasminogen activator to treat intracardiac thrombosis in extremely low-birth-weight infants Pediatric Critical Care Medicine. 12: e407-e409. PMID 21131893 DOI: 10.1097/PCC.0b013e3181fe449f  0.035
2016 Kent A, Scorrer T, Pollard AJ, Snape MD, Clarke P, Few K, Menson E, Varghese AS, Hughes S, Ladhani SN, Heath PT. Lymphocyte subpopulations in premature infants: an observational study. Archives of Disease in Childhood. Fetal and Neonatal Edition. PMID 27075591 DOI: 10.1136/archdischild-2015-309246  0.035
2001 Andreyev HJ, Ross PJ, Cunningham D, Clarke PA. Antisense treatment directed against mutated Ki-ras in human colorectal adenocarcinoma. Gut. 48: 230-7. PMID 11156646 DOI: 10.1136/gut.48.2.230  0.034
2009 Priddle H, Grabowska A, Morris T, Clarke PA, McKenzie AJ, Sottile V, Denning C, Young L, Watson S. Bioluminescence imaging of human embryonic stem cells transplanted in vivo in murine and chick models. Cloning and Stem Cells. 11: 259-67. PMID 19522673 DOI: 10.1089/Clo.2008.0056  0.034
2005 Chandola T, Clarke P, Wiggins RD, Bartley M. Who you live with and where you live: setting the context for health using multiple membership multilevel models. Journal of Epidemiology and Community Health. 59: 170-5. PMID 15650151 DOI: 10.1136/jech.2003.019539  0.034
2022 Howard J, Wynne K, Moldenhauer E, Clarke P, Maguire C, Bollard S, Yin X, Brennan L, Mooney L, Fitzsimons S, Halasz M, Aluri ER, Brougham DF, Kolch W, Dwyer RM, et al. A comparative analysis of extracellular vesicles (EVs) from human and feline plasma. Scientific Reports. 12: 10851. PMID 35761023 DOI: 10.1038/s41598-022-14211-z  0.034
2009 Clarke P. Control of apoptosis and autophagy by cellular signalling pathways. The Febs Journal. 276: 6049. PMID 19788419 DOI: 10.1111/j.1742-4658.2009.07328.x  0.034
2007 Awan AK, Iftikhar SY, Morris TM, Clarke PA, Grabowska AM, Waraich N, Watson SA. Androgen receptors may act in a paracrine manner to regulate oesophageal adenocarcinoma growth. European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. 33: 561-8. PMID 17254742 DOI: 10.1016/j.ejso.2006.12.001  0.033
1998 Andreyev HJ, Norman AR, Cunningham D, Oates JR, Clarke PA. Kirsten ras mutations in patients with colorectal cancer: the multicenter "RASCAL" study. Journal of the National Cancer Institute. 90: 675-84. PMID 9586664  0.033
2013 Clarke P, Milner MW. Post-discharge calls and improved satisfaction. Follow-up calls, other efforts improve patient experience, survey scores. Healthcare Executive. 28: 62, 64-5. PMID 23967531  0.033
1997 Andreyev HJ, Tilsed JV, Cunningham D, Sampson SA, Norman AR, Schneider HJ, Clarke PA. K-ras mutations in patients with early colorectal cancers. Gut. 41: 323-9. PMID 9378386  0.033
2006 Workman P, Clarke PA, Guillard S, Raynaud FI. Drugging the PI3 kinome. Nature Biotechnology. 24: 794-6. PMID 16841064 DOI: 10.1038/nbt0706-794  0.032
2019 Lee TTM, Clarke P, Prosser-Snelling E. Haemolytic disease of the fetus and newborn diagnosed after delivery of a baby to a mother with low anti-E antibody titres. Bmj Case Reports. 12. PMID 31501172 DOI: 10.1136/bcr-2019-229816  0.032
2017 Muniraman H, Gardner D, Skinner J, Paweletz A, Vayalakkad A, Chee YH, Clifford C, Sanka S, Venkatesh V, Curley A, Victor S, Turner MA, Clarke P. Biomarkers of hepatic injury and function in neonatal hypoxic ischemic encephalopathy and with therapeutic hypothermia. European Journal of Pediatrics. PMID 28741035 DOI: 10.1007/s00431-017-2956-2  0.031
2006 Clarke P, Ghani AC. Projections of the future course of the primary vCJD epidemic in the UK: inclusion of subclinical infection and the possibility of wider genetic susceptibility. Journal of the Royal Society, Interface. 2: 19-31. PMID 16849160 DOI: 10.1098/rsif.2004.0017  0.031
2014 Cook KL, Soto-Pantoja DR, Abu-Asab M, Clarke PA, Roberts DD, Clarke R. Mitochondria directly donate their membrane to form autophagosomes during a novel mechanism of parkin-associated mitophagy. Cell & Bioscience. 4: 16. PMID 24669863 DOI: 10.1186/2045-3701-4-16  0.03
2018 Faraday C, Hamad S, Jones K, Sim K, Cherian S, James A, Godambe S, New H, Kroll, Clarke P. Characteristics and incidence of transfusion-associated necrotizing enterocolitis in the UKCharacteristics and incidence of transfusion-associated necrotizing enterocolitis in the UK. The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 1-11. PMID 29945481 DOI: 10.1080/14767058.2018.1494147  0.03
2015 Clarke P, Mitchell SJ, Shearer MJ. Total and Differential Phylloquinone (Vitamin K₁) Intakes of Preterm Infants from All Sources during the Neonatal Period. Nutrients. 7: 8308-20. PMID 26426042 DOI: 10.3390/nu7105393  0.029
2020 Clarke P, Allen E, Atuona S, Cawley P. Delivery room cuddles for extremely preterm babies and parents: concept, practice, safety, parental feedback. Acta Paediatrica (Oslo, Norway : 1992). PMID 33305444 DOI: 10.1111/apa.15716  0.029
2010 Clarke P. Vitamin K prophylaxis for preterm infants. Early Human Development. 17-20. PMID 20106609 DOI: 10.1016/j.earlhumdev.2010.01.013  0.028
2019 Lynch TR, Hempel RJ, Whalley B, Byford S, Chamba R, Clarke P, Clarke S, Kingdon DG, O'Mahen H, Remington B, Rushbrook SC, Shearer J, Stanton M, Swales M, Watkins A, et al. Refractory depression - mechanisms and efficacy of radically open dialectical behaviour therapy (RefraMED): findings of a randomised trial on benefits and harms. The British Journal of Psychiatry : the Journal of Mental Science. 1-9. PMID 31317843 DOI: 10.1192/bjp.2019.53  0.028
2020 Mescall S, Dhamodaran M, Clarke P, Ponnusamy V. Current availability of cerebral function monitoring and therapeutic hypothermia equipment in UK neonatal units and networks. Archives of Disease in Childhood. Fetal and Neonatal Edition. PMID 33122247 DOI: 10.1136/archdischild-2020-320493  0.027
2018 Lally PJ, Montaldo P, Oliveira V, Soe A, Swamy R, Bassett P, Mendoza J, Atreja G, Kariholu U, Pattnayak S, Sashikumar P, Harizaj H, Mitchell M, Ganesh V, Harigopal S, ... ... Clarke P, et al. Magnetic resonance spectroscopy assessment of brain injury after moderate hypothermia in neonatal encephalopathy: a prospective multicentre cohort study. The Lancet. Neurology. PMID 30447969 DOI: 10.1016/S1474-4422(18)30325-9  0.027
2006 Ofoegbu BN, Clarke P, Robinson MJ. Nasal continuous positive airway pressure for neonatal back transfer. Acta Paediatrica (Oslo, Norway : 1992). 95: 752-3. PMID 16754561 DOI: 10.1080/08035250500482263  0.027
2010 Yin Y, Grabowska AM, Clarke PA, Whelband E, Robinson K, Argent RH, Tobias A, Kumari R, Atherton JC, Watson SA. Helicobacter pylori potentiates epithelial:mesenchymal transition in gastric cancer: links to soluble HB-EGF, gastrin and matrix metalloproteinase-7. Gut. 59: 1037-45. PMID 20584780 DOI: 10.1136/gut.2009.199794  0.027
2010 Ponnusamy V, Nath P, Bissett L, Willis K, Clarke P. Current availability of cerebral function monitoring and hypothermia therapy in UK neonatal units. Archives of Disease in Childhood. Fetal and Neonatal Edition. 95: F383-4. PMID 20530100 DOI: 10.1136/adc.2009.181578  0.026
2021 Sethi DK, Felgate H, Diaz M, Faust K, Kiy C, Clarke P, Härtel C, Rupp J, Webber MA. Chlorhexidine gluconate usage is associated with antiseptic tolerance in staphylococci from the neonatal intensive care unit. Jac-Antimicrobial Resistance. 3: dlab173. PMID 34806010 DOI: 10.1093/jacamr/dlab173  0.026
2020 A James S, Phillips S, Telatin A, Baker D, Ansorge R, Clarke P, J Hall L, R Carding S. Preterm Infants Harbour a Rapidly Changing Mycobiota That Includes Pathobionts. Journal of Fungi (Basel, Switzerland). 6. PMID 33182444 DOI: 10.3390/jof6040273  0.026
2017 Ponnusamy V, Clarke P. Roll-plate Alone Does Demonstrate Colonization in Silicone Neonatal Catheters. The Pediatric Infectious Disease Journal. 36: e29. PMID 27941473 DOI: 10.1097/INF.0000000000001370  0.026
2013 Jones AD, Clarke PA, Bartel DW. Rapid determination of seafloor acoustic reflectivity by exploiting frequency variability within striations data Oceans 2013 Mts/Ieee - San Diego: An Ocean in Common.  0.026
2003 Singh-Manoux A, Clarke P, Marmot M. Multiple measures of socio-economic position and psychosocial health: proximal and distal measures. International Journal of Epidemiology. 31: 1192-9; discussion 1. PMID 12540721 DOI: 10.1093/ije/31.6.1192  0.026
2007 Pearson SC, Clarke P. Changes in British men's use of family planning services between 1991 and 2000: secondary analysis of a national survey. The Journal of Family Planning and Reproductive Health Care / Faculty of Family Planning & Reproductive Health Care, Royal College of Obstetricians & Gynaecologists. 33: 183-7. PMID 17609077 DOI: 10.1783/147118907781004912  0.026
2001 Henwood M, Clarke PA, Smith AM, Watson SA. Expression of gastrin in developing gastric adenocarcinoma. The British Journal of Surgery. 88: 564-8. PMID 11298626 DOI: 10.1046/j.1365-2168.2001.01716.x  0.025
2009 Stanworth SJ, Clarke P, Watts T, Ballard S, Choo L, Morris T, Murphy MF, Roberts I. Prospective, observational study of outcomes in neonates with severe thrombocytopenia. Pediatrics. 124: e826-34. PMID 19841111 DOI: 10.1542/peds.2009-0332  0.025
2006 Singh J, Sinha SK, Clarke P, Byrne S, Donn SM. Mechanical ventilation of very low birth weight infants: is volume or pressure a better target variable? The Journal of Pediatrics. 149: 308-13. PMID 16939738 DOI: 10.1016/j.jpeds.2006.01.044  0.025
2012 Samarasekara SI, Booth D, Clarke P. Devastating coagulase-negative staphylococcal septicaemia in an extremely low birth weight infant. Bmj Case Reports. 2012. PMID 23188865 DOI: 10.1136/bcr-2012-007407  0.024
2019 Robertson C, Savva GM, Clapuci R, Jones J, Maimouni H, Brown E, Minocha A, Hall LJ, Clarke P. Incidence of necrotising enterocolitis before and after introducing routine prophylactic and probiotics. Archives of Disease in Childhood. Fetal and Neonatal Edition. PMID 31666311 DOI: 10.1136/archdischild-2019-317346  0.024
2003 Sacker A, Wiggins RD, Clarke P, Bartley M. Making sense of symptom checklists: a latent class approach to the first 9 years of the British Household Panel Survey. Journal of Public Health Medicine. 25: 215-22. PMID 14575196 DOI: 10.1093/pubmed/fdg056  0.024
2007 Ruggeberg JU, Collins C, Clarke P, Johnson N, Sinha R, Everest N, Chang J, Stanford E, Balmer P, Borrow R, Martin S, Robinson MJ, Moxon ER, Pollard AJ, Heath PT. Immunogenicity and induction of immunological memory of the heptavalent pneumococcal conjugate vaccine in preterm UK infants. Vaccine. 25: 264-71. PMID 17070968 DOI: 10.1016/j.vaccine.2006.07.036  0.024
2018 Williams E, Dassios T, Clarke P, Chowdhury O, Greenough A. Predictors of outcome of prematurely born infants with pulmonary interstitial emphysema. Acta Paediatrica (Oslo, Norway : 1992). PMID 29754462 DOI: 10.1111/Apa.14400  0.024
2006 Clarke P, Mitchell SJ, Wynn R, Sundaram S, Speed V, Gardener E, Roeves D, Shearer MJ. Vitamin K prophylaxis for preterm infants: a randomized, controlled trial of 3 regimens. Pediatrics. 118: e1657-66. PMID 17101711 DOI: 10.1542/peds.2005-2742  0.023
2011 Venkatesh V, Ponnusamy V, Anandaraj J, Chaudhary R, Malviya M, Clarke P, Arasu A, Curley A. Endotracheal intubation in a neonatal population remains associated with a high risk of adverse events European Journal of Pediatrics. 170: 223-227. PMID 20842378 DOI: 10.1007/s00431-010-1290-8  0.023
2016 Cawley P, Few K, Greenwood R, Malcolm P, Johnson G, Lally P, Thayyil S, Clarke P. Does Magnetic Resonance Brain Scanning at 3.0 Tesla Pose a Hyperthermic Challenge to Term Neonates? The Journal of Pediatrics. PMID 27318382 DOI: 10.1016/j.jpeds.2016.05.014  0.022
2012 Shastri AT, Abdulkarim D, Clarke P. Maternal diclofenac medication in pregnancy causing in utero closure of the fetal ductus arteriosus and hydrops. Pediatric Cardiology. 34: 1925-7. PMID 22872018 DOI: 10.1007/s00246-012-0461-y  0.022
2015 Clarke P, Gardner D, Venkatesh V, Victor S, Muniraman H, Turner MA, Curley A. Investigation of neonatal encephalopathy: the oft-lost placental 'black box'. Pediatric and Developmental Pathology : the Official Journal of the Society For Pediatric Pathology and the Paediatric Pathology Society. PMID 25826245 DOI: 10.2350/15-02-1611-LET.1  0.022
2016 Kent A, Ladhani SN, Andrews NJ, Scorrer T, Pollard AJ, Clarke P, Hughes SM, Heal C, Menson E, Chang J, Satodia P, Collinson AC, Faust SN, Goldblatt D, Miller E, et al. Schedules for Pneumococcal Vaccination of Preterm Infants: An RCT. Pediatrics. PMID 27503351 DOI: 10.1542/Peds.2015-3945  0.021
2018 Curley A, Stanworth SJ, Willoughby K, Fustolo-Gunnink SF, Venkatesh V, Hudson C, Deary A, Hodge R, Hopkins V, Lopez Santamaria B, Mora A, Llewelyn C, D'Amore A, Khan R, Onland W, ... ... Clarke P, et al. Randomized Trial of Platelet-Transfusion Thresholds in Neonates. The New England Journal of Medicine. PMID 30387697 DOI: 10.1056/NEJMoa1807320  0.021
2016 Dunne JM, Wertheim D, Clarke P, Kapellou O, Chisholm P, Boardman JP, Shah DK. Automated electroencephalographic discontinuity in cooled newborns predicts cerebral MRI and neurodevelopmental outcome. Archives of Disease in Childhood. Fetal and Neonatal Edition. PMID 27103657 DOI: 10.1136/archdischild-2015-309697  0.021
2015 Ponnusamy V, Venkatesh V, Clarke P. Skin antisepsis in the neonate: what should we use? Current Opinion in Infectious Diseases. 27: 244-50. PMID 24751895 DOI: 10.1097/QCO.0000000000000064  0.021
2018 Clarke P, Webber MA. Catheter sepsis and antisepsis: matters of life, death, obscurity and resistance. Archives of Disease in Childhood. Fetal and Neonatal Edition. PMID 29371239 DOI: 10.1136/archdischild-2017-313150  0.021
2005 Jones AD, Duncan AJ, Clarke PA, Maggi A. Simulation of time series received underwater from small explosive detonations in shallow ocean regions Annual Conference of the Australian Acoustical Society 2005, Acoustics 2005: Acoustics in a Changing Environment. 386-393.  0.02
2021 Nixon R, Ip THR, Jenkins B, Yip PK, Clarke P, Ponnusamy V, Michael-Titus AT, Koulman A, Shah DK. Lipid Profiles from Dried Blood Spots Reveal Lipidomic Signatures of Newborns Undergoing Mild Therapeutic Hypothermia after Hypoxic-Ischemic Encephalopathy. Nutrients. 13. PMID 34959853 DOI: 10.3390/nu13124301  0.02
1996 Clarke PA, Barnes KA, Startin JR, Ibe FI, Shepherd MJ. High performance liquid chromatography/atmospheric pressure chemical ionization-mass spectrometry for the determination of carotenoids Rapid Communications in Mass Spectrometry. 10: 1781-1785. DOI: 10.1002/(SICI)1097-0231(199611)10:14<1781::AID-RCM748>3.0.CO;2-D  0.019
2008 Chaudhary R, Clarke P. Current transfusion practices for platelets and fresh, frozen plasma in UK tertiary level neonatal units Acta Paediatrica, International Journal of Paediatrics. 97: 135. PMID 18076715 DOI: 10.1111/j.1651-2227.2007.00574.x  0.019
1996 Scudamore KA, Hetmanski MT, Clarke PA, Barnes KA, Startin JR. Analytical methods for the determination of sterigmatocystin in cheese, bread and corn products using HPLC with atmospheric pressure ionization mass spectrometric detection Food Additives and Contaminants. 13: 343-358. PMID 8718750  0.019
2015 Pal S, Jones J, Job S, Maynard L, Curley A, Clarke P. Characteristics of babies who unexpectedly survive long-term.after withdrawal of intensive care. Acta Paediatrica (Oslo, Norway : 1992). PMID 26600230 DOI: 10.1111/apa.13279  0.019
1996 Crews HM, Clarke PA, Lewis DJ, Owen LM, Strutt PR, Izquierdo A. Investigation of selenium speciation in in vitro gastrointestinal extracts of cooked cod by high-performance liquid chromatography-inductively coupled plasma mass spectrometry and electrospray mass spectrometry Journal of Analytical Atomic Spectrometry. 11: 1177-1182.  0.019
2010 Alam J, Ahlund S, Thalange NK, Clarke P. The disparate psychological and social support available for parents in UK tertiary-level neonatal units. Archives of Disease in Childhood. Fetal and Neonatal Edition. 95: F462. PMID 20551189 DOI: 10.1136/adc.2010.187021  0.018
2006 Leahy MJ, Hutto CJ, Clarke PA. The composition and structure of woody vegetation associated with piratebush, Buckleya distichophylla (Nutt.) Torr., on Poor Mountain, Virginia Castanea. 71: 31-44. DOI: 10.2179/04-25a.1  0.018
2005 Banks RE, Stanley AJ, Cairns DA, Barrett JH, Clarke P, Thompson D, Selby PJ. Influences of blood sample processing on low-molecular-weight proteome identified by surface-enhanced laser desorption/ionization mass spectrometry. Clinical Chemistry. 51: 1637-49. PMID 16002455 DOI: 10.1373/clinchem.2005.051417  0.018
2007 Clarke P, Will RG, Ghani AC. Is there the potential for an epidemic of variant Creutzfeldt-Jakob disease via blood transfusion in the UK? Journal of the Royal Society, Interface. 4: 675-84. PMID 17287181 DOI: 10.1098/rsif.2007.0216  0.018
2012 Vergnano S, Menson E, Smith Z, Kennea N, Embleton N, Clarke P, Watts T, Heath PT, Health PT. Characteristics of Invasive Staphylococcus aureus in United Kingdom Neonatal Units. The Pediatric Infectious Disease Journal. 30: 850-4. PMID 21654546 DOI: 10.1097/INF.0b013e318224546d  0.018
2018 Duffield SD, Clarke P. Current use of probiotics to prevent necrotising enterocolitis. Archives of Disease in Childhood. Fetal and Neonatal Edition. 104: F228. PMID 30464004 DOI: 10.1136/archdischild-2018-316199  0.018
1999 Clarke PA. RNA footprinting and modification interference analysis. Methods in Molecular Biology (Clifton, N.J.). 118: 73-91. PMID 10549516 DOI: 10.1385/1-59259-676-2:73  0.017
2017 Muniraman H, Gardner D, Skinner J, Paweletz A, Vayalakkad A, Chee YH, Clifford C, Sanka S, Venkatesh V, Curley A, Victor S, Turner MA, Clarke P. Erratum to: Biomarkers of hepatic injury and function in neonatal hypoxic ischemic encephalopathy and with therapeutic hypothermia. European Journal of Pediatrics. PMID 28785794 DOI: 10.1007/s00431-017-2980-2  0.017
2009 Ahlund S, Clarke P, Hill J, Thalange NK. Post-traumatic stress symptoms in mothers of very low birth weight infants 2-3 years post-partum. Archives of Women's Mental Health. 12: 261-4. PMID 19322638 DOI: 10.1007/s00737-009-0067-4  0.017
2020 Birbal R, Martin Jimenez C, Clarke P, Muthukumar P. Fulminant fatal necrotising fasciitis in an extremely preterm infant. Archives of Disease in Childhood. Fetal and Neonatal Edition. PMID 33106274 DOI: 10.1136/archdischild-2020-320339  0.017
2014 Shah DK, Wusthoff CJ, Clarke P, Wyatt JS, Ramaiah SM, Dias RJ, Becher JC, Kapellou O, Boardman JP. Electrographic seizures are associated with brain injury in newborns undergoing therapeutic hypothermia. Archives of Disease in Childhood. Fetal and Neonatal Edition. 99: F219-24. PMID 24443407 DOI: 10.1136/archdischild-2013-305206  0.017
2011 Clarke P, Booth D. Copying medical summaries on deceased infants to bereaved parents. Acta Paediatrica (Oslo, Norway : 1992). 100: 1262-6. PMID 21418103 DOI: 10.1111/j.1651-2227.2011.02276.x  0.017
2005 Clarke P, Mitchell SJ, Sundaram S, Sharma V, Wynn R, Shearer MJ. Vitamin K status of preterm infants with a prolonged prothrombin time. Acta Paediatrica (Oslo, Norway : 1992). 94: 1822-4. PMID 16421045 DOI: 10.1080/08035250500268233  0.016
2014 Curley A, Venkatesh V, Stanworth S, Clarke P, Watts T, New H, Willoughby K, Khan R, Muthukumar P, Deary A. Platelets for neonatal transfusion - study 2: a randomised controlled trial to compare two different platelet count thresholds for prophylactic platelet transfusion to preterm neonates. Neonatology. 106: 102-6. PMID 24851997 DOI: 10.1159/000358481  0.016
2005 Sacker A, Clarke P, Wiggins RD, Bartley M. Social dynamics of health inequalities: a growth curve analysis of aging and self assessed health in the British household panel survey 1991-2001. Journal of Epidemiology and Community Health. 59: 495-501. PMID 15911646 DOI: 10.1136/jech.2004.026278  0.016
2010 Nath P, Ponnusamy V, Willis K, Bissett L, Clarke P. Current practices of high and low flow oxygen therapy and humidification in UK neonatal units. Pediatrics International : Official Journal of the Japan Pediatric Society. 52: 893-4. PMID 21166951 DOI: 10.1111/j.1442-200X.2010.03274.x  0.016
2015 Hollingsworth C, Clarke P, Sharma A, Upton M. National survey of umbilical venous catheterisation practices in the wake of two deaths. Archives of Disease in Childhood. Fetal and Neonatal Edition. 100: F371-2. PMID 25862724 DOI: 10.1136/archdischild-2015-308327  0.016
2015 Job S, Damodaran S, Brooke P, Mo J, Pickworth F, Clarke P. Incidence and identification of inadvertent lumbar vein catheterisation in the NICU. Archives of Disease in Childhood. Fetal and Neonatal Edition. 100: F277-8. PMID 25589147 DOI: 10.1136/archdischild-2014-307095  0.015
2007 Clarke PA. Driving pharmacists away from a career in the NHS [2] Pharmaceutical Journal. 279: 153.  0.015
2011 Alanoor RK, Jones J, Clarke P. Recorded birth weights of UK preterm babies are commonly overestimated. Archives of Disease in Childhood. Fetal and Neonatal Edition. 96: F390. PMID 21835839 DOI: 10.1136/archdischild-2011-300296  0.015
2012 Jones AD, Bartel DW, Clarke PA. An application of range-frequency striations to seafloor inversion in shallow oceans Australian Acoustical Society Conference 2012, Acoustics 2012: Acoustics, Development, and the Environment. 567-573.  0.015
2007 Garske T, Clarke P, Ghani AC. The transmissibility of highly pathogenic avian influenza in commercial poultry in industrialised countries. Plos One. 2: e349. PMID 17406673 DOI: 10.1371/journal.pone.0000349  0.014
2007 Clarke P, Shearer MJ. Vitamin K deficiency bleeding after missed prophylaxis: rapid synergistic effect of vitamin K therapy on hemostasis. Southern Medical Journal. 100: 612-3. PMID 17593579 DOI: 10.1097/SMJ.0b013e31805f6e9b  0.014
2014 Ponnusamy V, Clarke P. "Matching Michigan" in neonatal intensive care units: a plea for uniform data presentation. The Pediatric Infectious Disease Journal. 32: 927-8. PMID 23856716 DOI: 10.1097/INF.0b013e318292f57f  0.014
2019 Chen Y, Brook TC, Alcon-Giner C, Clarke P, Hall LJ, Hoyles L. Draft Genome Sequence of Raoultella ornithinolytica P079F W, Isolated from the Feces of a Preterm Infant. Microbiology Resource Announcements. 8. PMID 31416862 DOI: 10.1128/MRA.00493-19  0.013
2012 Ponnusamy V, Venkatesh V, Curley A, Musonda P, Brown N, Tremlett C, Clarke P. Segmental percutaneous central venous line cultures for diagnosis of catheter-related sepsis Archives of Disease in Childhood: Fetal and Neonatal Edition. 97: F273-F278. PMID 22174018 DOI: 10.1136/archdischild-2011-300822  0.013
2020 Dhamodaran M, Firth C, Webber MA, Clarke P. Bathing babies: current practices in UK neonatal intensive care units. Archives of Disease in Childhood. Fetal and Neonatal Edition. PMID 33172873 DOI: 10.1136/archdischild-2020-320355  0.013
2012 Clarke PA, Jones AD. Shallow water seafloor inversion using ship-generated striation patterns Australian Acoustical Society Conference 2012, Acoustics 2012: Acoustics, Development, and the Environment. 574-581.  0.012
2021 Birbal R, Olaniyi O, Clarke P. Extreme preterm neonate with fetal warfarin syndrome. Archives of Disease in Childhood. Fetal and Neonatal Edition. PMID 34949636 DOI: 10.1136/archdischild-2021-323295  0.012
2009 Clarke PA. Australian aboriginal ethnometeorology and seasonal calendars History and Anthropology. 20: 79-106. DOI: 10.1080/02757200902867677  0.012
2015 Ibrahim T, Few K, Greenwood R, Smith C, Malcolm P, Johnson G, Lally P, Thayyil S, Clarke P. 'Feed and wrap' or sedate and immobilise for neonatal brain MRI? Archives of Disease in Childhood. Fetal and Neonatal Edition. PMID 26126844 DOI: 10.1136/archdischild-2015-308847  0.012
2014 Catford K, Muthukumar P, Reddy C, Al Atrash H, Clarke P, Venkatesh V, Curley AE. Routine neonatal coagulation testing increases use of fresh-frozen plasma. Transfusion. 54: 1444-5. PMID 24819080 DOI: 10.1111/trf.12610  0.011
2020 Brown TJ, Gentry S, Bauld L, Boyle EM, Clarke P, Hardeman W, Holland R, Naughton F, Orton S, Ussher M, Notley C. Systematic Review of Behaviour Change Techniques within Interventions to Reduce Environmental Tobacco Smoke Exposure for Children. International Journal of Environmental Research and Public Health. 17. PMID 33105823 DOI: 10.3390/ijerph17217731  0.011
2019 Chen Y, Brook TC, Alcon-Giner C, Clarke P, Hall LJ, Hoyles L. Draft Genome Sequences of Citrobacter freundii and Citrobacter murliniae Strains Isolated from the Feces of Preterm Infants. Microbiology Resource Announcements. 8. PMID 31416863 DOI: 10.1128/MRA.00494-19  0.011
2013 Venkatesh V, Curley AE, Clarke P, Watts T, Stanworth SJ. Do we know when to treat neonatal thrombocytopaenia? Archives of Disease in Childhood. Fetal and Neonatal Edition. 98: F380-2. PMID 23531628 DOI: 10.1136/archdischild-2012-302535  0.011
2018 Wang J, Kortsalioudaki C, Heath PT, Buttery J, Clarke P, Gkentzi D, Anthony M, Tan K. Epidemiology and healthcare factors associated with neonatal enterococcal infections. Archives of Disease in Childhood. Fetal and Neonatal Edition. PMID 30425112 DOI: 10.1136/archdischild-2018-315387  0.01
2020 Muniraman H, Ali M, Cawley P, Hillyer J, Heathcote A, Ponnusamy V, Coleman Z, Hammonds K, Raiyani C, Gait-Carr E, Myers S, Hunt K, Govande V, Jain A, Clark R, ... ... Clarke P, et al. Parental perceptions of the impact of neonatal unit visitation policies during COVID-19 pandemic. Bmj Paediatrics Open. 4: e000899. PMID 34192184 DOI: 10.1136/bmjpo-2020-000899  0.01
2019 Nichols A, Clarke P, Notley C. Parental smoking and support in the NICU. Archives of Disease in Childhood. Fetal and Neonatal Edition. PMID 30636693 DOI: 10.1136/archdischild-2018-316413  0.01
2015 Job S, Clarke P. Current UK practices in steroid treatment of chronic lung disease. Archives of Disease in Childhood. Fetal and Neonatal Edition. 100: F371. PMID 25762149 DOI: 10.1136/archdischild-2014-308060  0.01
2015 Ens EJ, Pert P, Clarke PA, Budden M, Clubb L, Doran B, Douras C, Gaikwad J, Gott B, Leonard S, Locke J, Packer J, Turpin G, Wason S. Indigenous biocultural knowledge in ecosystem science and management: Review and insight from Australia Biological Conservation. 181: 133-149. DOI: 10.1016/j.biocon.2014.11.008  0.01
2015 Clarke PA. Australian aboriginal astronomy and cosmology Handbook of Archaeoastronomy and Ethnoastronomy. 2223-2230. DOI: 10.1007/978-1-4614-6141-8_240  0.01
2014 Ponnusamy V, Perperoglou A, Venkatesh V, Curley A, Brown N, Tremlett C, Clarke P. Skin colonisation at the catheter exit site is strongly associated with catheter colonisation and catheter-related sepsis Acta Paediatrica (Oslo, Norway : 1992). 103: 1233-1238. PMID 25164200 DOI: 10.1111/apa.12779  0.01
2014 Sesham R, Oddie S, Embleton ND, Clarke P. Probiotics for preterm neonates: parents' perspectives and present prevalence. Archives of Disease in Childhood. Fetal and Neonatal Edition. 99: F345. PMID 24723695 DOI: 10.1136/archdischild-2014-306344  0.01
2014 McNutt A, Thornton T, Sizer P, Curley A, Clarke P. Opinions of UK perinatal health care professionals on home birth. Midwifery. 30: 839-46. PMID 24035398 DOI: 10.1016/j.midw.2013.08.007  0.01
2013 Heron TJ, Faraday CM, Clarke P. The hidden harms of Matching Michigan. Archives of Disease in Childhood. Fetal and Neonatal Edition. 98: F466-7. PMID 23749052 DOI: 10.1136/archdischild-2013-304378  0.01
2013 Clarke PA. The aboriginal ethnobotany of the adelaide region, South Australia Transactions of the Royal Society of South Australia. 137: 97-126.  0.01
2012 Workman P, Clarke PA, Al-Lazikani B. Personalized medicine: patient-predictive panel power. Cancer Cell. 21: 455-8. PMID 22516256 DOI: 10.1016/j.ccr.2012.03.030  0.01
2011 Shastri AT, Samarasekara S, Muniraman H, Clarke P. Cardiac troponin I concentrations in neonates with hypoxic-ischaemic encephalopathy. Acta Paediatrica (Oslo, Norway : 1992). 101: 26-9. PMID 21801203 DOI: 10.1111/j.1651-2227.2011.02432.x  0.01
2011 Shastri AT, Clarke P, Roy R. Pulse oximetry screening for detection of critical congenital heart disease in newborns: a survey of current practices in the United Kingdom. Acta Paediatrica (Oslo, Norway : 1992). 100: 636-7. PMID 21166863 DOI: 10.1111/j.1651-2227.2010.02126.x  0.01
2010 Jones AD, Duncan AJ, Maggi A, Sendt J, Clarke PA. Modelling acoustic reflection loss at the ocean surface for small angles of incidence Oceans'10 Ieee Sydney, Oceanssyd 2010. DOI: 10.1109/OCEANSSYD.2010.5603922  0.01
2010 Horlick GN, Clarke PA. WTO subsidies discipline during and after the crisis Journal of International Economic Law. 13: 859-874. DOI: 10.1093/jiel/jgq043  0.01
2010 Jones AD, Clarke PA. Rapid seafloor inversion in shallow oceans using broadband acoustic data 20th International Congress On Acoustics 2010, Ica 2010 - Incorporating Proceedings of the 2010 Annual Conference of the Australian Acoustical Society. 1: 305-316.  0.01
2010 Jones AD, Duncan AJ, Maggi A, Clarke PA, Sendt J. Aspects of practical models of acoustic reflection loss at the ocean surface 20th International Congress On Acoustics 2010, Ica 2010 - Incorporating Proceedings of the 2010 Annual Conference of the Australian Acoustical Society. 1: 396-403.  0.01
2009 Clarke PA, Thornton MJ. Failure of a water-bath design intravenous fluid warmer. Canadian Journal of Anaesthesia = Journal Canadien D'AnesthéSie. 56: 876-7. PMID 19697093 DOI: 10.1007/s12630-009-9164-0  0.01
2009 Howes BW, Clarke PA, Cook TM. The National Joint Registry may fail to collect accurate, validated anaesthetic data. Anaesthesia. 64: 694-5. PMID 19453336 DOI: 10.1111/j.1365-2044.2009.05956.x  0.01
2009 Clarke PA. Leadership, beyond project management Industrial and Commercial Training. 41: 187-194. DOI: 10.1108/00197850910962760  0.01
2009 Jones AD, Sendt J, Duncan AJ, Clarke PA, Maggi A. Modelling the acoustic reflection loss at the rough ocean surface Annual Conference of the Australian Acoustical Society 2009 - Acoustics 2009: Research to Consulting. 283-290.  0.01
2008 Jones AD, Sendt J, Duncan AJ, Zhang ZY, Clarke PA. Modelling acoustic reflection loss at the ocean surface - An Australian study Annual Conference of the Australian Acoustical Society, Aas'08. 329-337.  0.01
2008 Jones AD, Day GJ, Clarke PA. Single parameter description of seafloors for shallow oceans Proceedings - European Conference On Noise Control. 1725-1730.  0.01
2007 Clarke P, Shearer MJ. Vitamin K deficiency bleeding: the readiness is all. Archives of Disease in Childhood. 92: 741-3. PMID 17522165 DOI: 10.1136/adc.2007.116962  0.01
2007 Clarke PA. Indigenous spirit and ghost folklore of "settled" Australia Folklore. 118: 141-161. DOI: 10.1080/00155870701337346  0.01
2007 Jones AD, Sendt J, Duncan AJ, Clarke PA, Zhang ZY, Maggi AL. Comparison of transmission loss models at mid-frequency against shallow water data 14th International Congress On Sound and Vibration 2007, Icsv 2007. 2: 916-923.  0.01
2007 Clarke PA. Should everyone pay the same income tax as well? [4] Pharmaceutical Journal. 279: 563.  0.01
2006 Jones AD, Maggi AL, Clarke PA, Duncan AJ. Analysis and simulation of an extended data set of waveforms received from small explosions in shallow oceans 1st Australasian Acoustical Societies' Conference 2006, Acoustics 2006: Noise of Progress. 485-492.  0.01
2002 Jones AD, Sendt JS, Clarke PA, Exelby JR. Seafloor data for operational predictions of transmission loss in shallow ocean areas Acoustics Australia. 30: 27-31.  0.01
1999 Clarke PA. Dangerous remedies? [3] Pharmaceutical Journal. 263: 708.  0.01
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