| Year |
Citation |
Score |
| 2017 |
Khorsand F, Murphy CD, Whitehead AJ, Engel PC. Biocatalytic stereoinversion of d-para-bromophenylalanine in a one-pot three-enzyme reaction Green Chemistry. 19: 503-510. DOI: 10.1039/C6Gc01922F |
0.396 |
|
| 2016 |
Oliveira T, Sharkey MA, Engel PC, Khan AR. Crystal structure of a chimaeric bacterial glutamate dehydrogenase. Acta Crystallographica. Section F, Structural Biology Communications. 72: 462-466. PMID 27303899 DOI: 10.1107/S2053230X16007305 |
0.444 |
|
| 2014 |
Yu X, Wang X, Engel PC. The specificity and kinetic mechanism of branched-chain amino acid aminotransferase from Escherichia coli studied with a new improved coupled assay procedure and the enzyme's potential for biocatalysis. The Febs Journal. 281: 391-400. PMID 24206068 DOI: 10.1111/Febs.12609 |
0.454 |
|
| 2014 |
Engel PC. Glutamate dehydrogenases: the why and how of coenzyme specificity. Neurochemical Research. 39: 426-32. PMID 23761034 DOI: 10.1007/S11064-013-1089-X |
0.455 |
|
| 2013 |
Sharkey MA, Oliveira TF, Engel PC, Khan AR. Structure of NADP(+)-dependent glutamate dehydrogenase from Escherichia coli--reflections on the basis of coenzyme specificity in the family of glutamate dehydrogenases. The Febs Journal. 280: 4681-92. PMID 23879525 DOI: 10.1111/Febs.12439 |
0.441 |
|
| 2013 |
Munawar N, Engel PC. Prospects for robust biocatalysis: engineering of novel specificity in a halophilic amino acid dehydrogenase. Extremophiles : Life Under Extreme Conditions. 17: 43-51. PMID 23104166 DOI: 10.1007/S00792-012-0491-7 |
0.454 |
|
| 2012 |
Yu X, Bresser J, Schall I, Djurdjevic I, Buckel W, Wang X, Engel PC. Development of a satisfactory and general continuous assay for aminotransferases by coupling with (R)-2-hydroxyglutarate dehydrogenase. Analytical Biochemistry. 431: 127-31. PMID 23000002 DOI: 10.1016/J.Ab.2012.09.009 |
0.404 |
|
| 2012 |
Sharkey MA, Gori A, Capone M, Engel PC. Reversal of the extreme coenzyme selectivity of Clostridium symbiosum glutamate dehydrogenase. The Febs Journal. 279: 3003-9. PMID 22747945 DOI: 10.1111/J.1742-4658.2012.08681.X |
0.425 |
|
| 2012 |
Munawar N, Engel PC. Overexpression in a non-native halophilic host and biotechnological potential of NAD+-dependent glutamate dehydrogenase from Halobacterium salinarum strain NRC-36014. Extremophiles : Life Under Extreme Conditions. 16: 463-76. PMID 22527040 DOI: 10.1007/S00792-012-0446-Z |
0.447 |
|
| 2012 |
Oliveira T, Panjikar S, Carrigan JB, Hamza M, Sharkey MA, Engel PC, Khan AR. Crystal structure of NAD+-dependent Peptoniphilus asaccharolyticus glutamate dehydrogenase reveals determinants of cofactor specificity. Journal of Structural Biology. 177: 543-52. PMID 22068154 DOI: 10.1016/J.Jsb.2011.10.006 |
0.447 |
|
| 2011 |
Griffin J, Engel PC. An Examination by Site-Directed Mutagenesis of Putative Key Residues in the Determination of Coenzyme Specificity in Clostridial NAD-Dependent Glutamate Dehydrogenase. Enzyme Research. 2011: 595793. PMID 21876794 DOI: 10.4061/2011/595793 |
0.441 |
|
| 2011 |
Wang XT, Mion B, Aherne A, Engel PC. Molecular recruitment as a basis for negative dominant inheritance? propagation of misfolding in oligomers of IMPDH1, the mutated enzyme in the RP10 form of retinitis pigmentosa. Biochimica Et Biophysica Acta. 1812: 1472-6. PMID 21791244 DOI: 10.1016/J.Bbadis.2011.07.006 |
0.351 |
|
| 2011 |
Storm J, Perner J, Aparicio I, Patzewitz EM, Olszewski K, Llinas M, Engel PC, Müller S. Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development. Malaria Journal. 10: 193. PMID 21756354 DOI: 10.1186/1475-2875-10-193 |
0.36 |
|
| 2011 |
Sharkey MA, Maher MA, Guyonvarch A, Engel PC. Kinetic characterisation of recombinant Corynebacterium glutamicum NAD+-dependent LDH over-expressed in E. coli and its rescue of an lldD- phenotype in C. glutamicum: the issue of reversibility re-examined. Archives of Microbiology. 193: 731-40. PMID 21567176 DOI: 10.1007/S00203-011-0711-Z |
0.369 |
|
| 2011 |
Capone M, Scanlon D, Griffin J, Engel PC. Re-engineering the discrimination between the oxidized coenzymes NAD+ and NADP+ in clostridial glutamate dehydrogenase and a thorough reappraisal of the coenzyme specificity of the wild-type enzyme. The Febs Journal. 278: 2460-8. PMID 21564547 DOI: 10.1111/J.1742-4658.2011.08172.X |
0.493 |
|
| 2011 |
Engel PC. Making biochemistry count: life among the amino acid dehydrogenases. Biochemical Society Transactions. 39: 425-9. PMID 21428913 DOI: 10.1042/Bst0390425 |
0.445 |
|
| 2011 |
Engel PC. A marriage full of surprises: forty-five years living with glutamate dehydrogenase. Neurochemistry International. 59: 489-94. PMID 21419817 DOI: 10.1016/J.Neuint.2011.03.014 |
0.452 |
|
| 2010 |
Griffin J, Engel PC. The -SH Protection Method for Determining Accurate K(d) Values for Enzyme-Coenzyme Complexes of NAD-Dependent Glutamate Dehydrogenase and Engineered Mutants: Evidence for Nonproductive NADPH Complexes. Enzyme Research. 2010: 951472. PMID 21048875 DOI: 10.4061/2010/951472 |
0.384 |
|
| 2010 |
Oliveira TF, Carrigan JB, Hamza MA, Sharkey MA, Engel PC, Khan AR. Crystallization and preliminary structural analyses of glutamate dehydrogenase from Peptoniphilus asaccharolyticus. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 523-6. PMID 20445250 DOI: 10.1107/S1744309110010006 |
0.431 |
|
| 2010 |
Aparicio IM, Marín-Menéndez A, Bell A, Engel PC. Susceptibility of Plasmodium falciparum to glutamate dehydrogenase inhibitors--a possible new antimalarial target. Molecular and Biochemical Parasitology. 172: 152-5. PMID 20399810 DOI: 10.1016/J.Molbiopara.2010.04.002 |
0.313 |
|
| 2010 |
Wang XG, Zhang P, Lynch S, Engel PC. Forced evolution of Escherichia coli cells with the ability to effectively utilize non-natural amino acids l-tert-leucine, l-norleucine and γ-methyl-l-leucine Biocatalysis and Biotransformation. 28: 293-303. DOI: 10.3109/10242422.2010.514047 |
0.334 |
|
| 2010 |
Engel PC, Paradisi F. Novel enzymes for biotransformation and resolution of alpha-amino acids Comprehensive Natural Products Ii: Chemistry and Biology. 5: 71-90. |
0.533 |
|
| 2009 |
Sala Frigerio C, Kukar TL, Fauq A, Engel PC, Golde TE, Walsh DM. An NSAID-like compound, FT-9, preferentially inhibits gamma-secretase cleavage of the amyloid precursor protein compared to its effect on amyloid precursor-like protein 1. Biochemistry. 48: 10894-904. PMID 19821615 DOI: 10.1021/Bi901237K |
0.302 |
|
| 2009 |
Chen S, Engel PC. Efficient screening for new amino acid dehydrogenase activity: directed evolution of Bacillus sphaericus phenylalanine dehydrogenase towards activity with an unsaturated non-natural amino acid. Journal of Biotechnology. 142: 127-34. PMID 19501264 DOI: 10.1016/J.Jbiotec.2009.03.005 |
0.395 |
|
| 2009 |
Wang XT, Engel PC. Clinical mutants of human glucose 6-phosphate dehydrogenase: impairment of NADP(+) binding affects both folding and stability. Biochimica Et Biophysica Acta. 1792: 804-9. PMID 19465117 DOI: 10.1016/J.Bbadis.2009.05.003 |
0.433 |
|
| 2009 |
Sharkey MA, Engel PC. Modular coenzyme specificity: a domain-swopped chimera of glutamate dehydrogenase. Proteins. 77: 268-78. PMID 19425107 DOI: 10.1002/Prot.22433 |
0.381 |
|
| 2009 |
Wang XT, Engel PC. An optimised system for refolding of human glucose 6-phosphate dehydrogenase. Bmc Biotechnology. 9: 19. PMID 19284595 DOI: 10.1186/1472-6750-9-19 |
0.429 |
|
| 2009 |
Lamm AS, Khare A, Rosazza JPN, Taglieber A, Schulz F, Hollmann F, Rusek M, Reetz MT, Gefflaut T, Sagot E, Bolte J, Mihara H, Esaki N, Conway P, Paradisi F, ... Engel P, et al. Reduction of Functional Groups Practical Methods For Biocatalysis and Biotransformations. 295-298. DOI: 10.1002/9780470748589.ch10 |
0.399 |
|
| 2008 |
Paradisi F, Conway PA, Maguire AR, Engel PC. Engineered dehydrogenase biocatalysts for non-natural amino acids: efficient isolation of the D-enantiomer from racemic mixtures. Organic & Biomolecular Chemistry. 6: 3611-5. PMID 19082164 DOI: 10.1039/B809147A |
0.642 |
|
| 2008 |
Wang XT, Chan TF, Lam VM, Engel PC. What is the role of the second "structural" NADP+-binding site in human glucose 6-phosphate dehydrogenase? Protein Science : a Publication of the Protein Society. 17: 1403-11. PMID 18493020 DOI: 10.1110/Ps.035352.108 |
0.438 |
|
| 2008 |
Hamza MA, Engel PC. Homotropic allosteric control in clostridial glutamate dehydrogenase: different mechanisms for glutamate and NAD+? Febs Letters. 582: 1816-20. PMID 18472008 DOI: 10.1016/J.Febslet.2008.04.049 |
0.436 |
|
| 2008 |
Carrigan JB, Engel PC. The structural basis of proteolytic activation of bovine glutamate dehydrogenase. Protein Science : a Publication of the Protein Society. 17: 1346-53. PMID 18467497 DOI: 10.1110/Ps.034785.108 |
0.445 |
|
| 2008 |
Sharkey MA, Engel PC. Apparent negative co-operativity and substrate inhibition in overexpressed glutamate dehydrogenase from Escherichia coli. Fems Microbiology Letters. 281: 132-9. PMID 18294195 DOI: 10.1111/J.1574-6968.2008.01086.X |
0.468 |
|
| 2008 |
Huang Y, Choi MY, Au SW, Au DM, Lam VM, Engel PC. Purification and detailed study of two clinically different human glucose 6-phosphate dehydrogenase variants, G6PD(Plymouth) and G6PD(Mahidol): Evidence for defective protein folding as the basis of disease. Molecular Genetics and Metabolism. 93: 44-53. PMID 17959407 DOI: 10.1016/J.Ymgme.2007.08.122 |
0.391 |
|
| 2007 |
Carrigan JB, Engel PC. Probing the determinants of coenzyme specificity in Peptostreptococcus asaccharolyticus glutamate dehydrogenase by site-directed mutagenesis. The Febs Journal. 274: 5167-74. PMID 17850332 DOI: 10.1111/J.1742-4658.2007.06038.X |
0.5 |
|
| 2007 |
Hamza MA, Martin SR, Engel PC. The contribution of tryptophan residues to conformational changes in clostridial glutamate dehydrogenase--W64 and W449 as mediators of the cooperative response to glutamate. The Febs Journal. 274: 4126-34. PMID 17645547 DOI: 10.1111/J.1742-4658.2007.05940.X |
0.44 |
|
| 2007 |
Paradisi F, Collins S, Maguire AR, Engel PC. Phenylalanine dehydrogenase mutants: efficient biocatalysts for synthesis of non-natural phenylalanine derivatives. Journal of Biotechnology. 128: 408-11. PMID 16996633 DOI: 10.1016/J.Jbiotec.2006.08.008 |
0.554 |
|
| 2007 |
Chen S, Engel P. Alteration of substrate specificity of phenylalanine dehydrogenase from Bacillus sphaericus towards an aliphatic unsaturated amino acid by directed evolution Journal of Biotechnology. 131: S116-S117. DOI: 10.1016/J.Jbiotec.2007.07.203 |
0.399 |
|
| 2007 |
Hamza MA, Engel PC. Enhancing long-term thermal stability in mesophilic glutamate dehydrogenase from Clostridium symbiosum by eliminating cysteine residues Enzyme and Microbial Technology. 41: 706-710. DOI: 10.1016/J.Enzmictec.2007.06.008 |
0.418 |
|
| 2007 |
Chen S, Engel PC. An engineered mutant, L307V of phenylalanine dehydrogenase from Bacillus sphaericus: high activity and stability in organic-aqueous solvent mixtures and utility for synthesis of non-natural l-amino acids Enzyme and Microbial Technology. 40: 1407-1411. DOI: 10.1016/J.Enzmictec.2006.10.021 |
0.403 |
|
| 2006 |
Wang XT, Lam VM, Engel PC. Functional properties of two mutants of human glucose 6-phosphate dehydrogenase, R393G and R393H, corresponding to the clinical variants G6PD Wisconsin and Nashville. Biochimica Et Biophysica Acta. 1762: 767-74. PMID 16934959 DOI: 10.1016/J.Bbadis.2006.06.014 |
0.395 |
|
| 2006 |
Faulkner E, Barrett M, Okor S, Kieran P, Casey E, Paradisi F, Engel P, Glennon B. Use of fed-batch cultivation for achieving high cell densities for the pilot-scale production of a recombinant protein (phenylalanine dehydrogenase) in Escherichia coli Biotechnology Progress. 22: 889-897. PMID 16739976 DOI: 10.1021/Bp050327+ |
0.517 |
|
| 2005 |
Cainelli G, Engel PC, Galletti P, Giacomini D, Gualandi A, Paradisi F. Engineered phenylalanine dehydrogenase in organic solvents: homogeneous and biphasic enzymatic reactions. Organic & Biomolecular Chemistry. 3: 4316-20. PMID 16327891 DOI: 10.1039/B510816K |
0.536 |
|
| 2005 |
O'Reilly LP, Andresen BS, Engel PC. Two novel variants of human medium chain acyl-CoA dehydrogenase (MCAD). K364R, a folding mutation, and R256T, a catalytic-site mutation resulting in a well-folded but totally inactive protein. The Febs Journal. 272: 4549-57. PMID 16128823 DOI: 10.1111/J.1742-4658.2005.04878.X |
0.341 |
|
| 2005 |
Wang XT, Lam VM, Engel PC. Marked decrease in specific activity contributes to disease phenotype in two human glucose 6-phosphate dehydrogenase mutants, G6PD(Union) and G6PD(Andalus). Human Mutation. 26: 284. PMID 16088936 DOI: 10.1002/Humu.9367 |
0.436 |
|
| 2005 |
Paradisi F, Woolfson R, Geoghegan KF, Engel PC. Identification of the residue responsible for catalysing regeneration of activity in the inactive glutamate dehydrogenase mutant D165N. Febs Letters. 579: 2830-2. PMID 15878554 DOI: 10.1016/J.Febslet.2005.03.098 |
0.631 |
|
| 2005 |
Ingoldsby LM, Geoghegan KF, Hayden BM, Engel PC. The discovery of four distinct glutamate dehydrogenase genes in a strain of Halobacterium salinarum. Gene. 349: 237-44. PMID 15780999 DOI: 10.1016/J.Gene.2005.01.011 |
0.325 |
|
| 2005 |
Paradisi F, Dean JL, Geoghegan KF, Engel PC. Spontaneous chemical reversion of an active site mutation: deamidation of an asparagine residue replacing the catalytic aspartic acid of glutamate dehydrogenase. Biochemistry. 44: 3636-43. PMID 15736973 DOI: 10.1021/Bi047679U |
0.633 |
|
| 2005 |
Carrigan JB, Coughlan S, Engel PC. Properties of the thermostable glutamate dehydrogenase of the mesophilic anaerobe Peptostreptoccus asaccharolyticus purified by a novel method after over-expression in an Escherichia coli host. Fems Microbiology Letters. 244: 53-9. PMID 15727821 DOI: 10.1016/J.Femsle.2005.01.026 |
0.503 |
|
| 2005 |
Paradisi F, Gualandi A, Galletti P, Giacomini D, Cainelli G, Engel PC. Immobilised enzyme to perform enantiomerically pure reductive aminations in presence of organic solvents Aiche Annual Meeting, Conference Proceedings. 9554. |
0.524 |
|
| 2005 |
Engel PC, Paradisi F, Moynihan E, Maguire AR. Mutants of phenylalanine dehydrogenase: New bio-catalysts in the asymmetric synthesis and racemic resolution of non-natural amino acids Aiche Annual Meeting, Conference Proceedings. 12223-12227. |
0.479 |
|
| 2005 |
Faulkner E, Barrett M, Okor S, Paradisi F, Engel P, Casey E, Glennon B. The use of fed batch cultivation for achieving high cell densities for the pilot scale production of a recombinant protein (Phenylalanine dehydrogenase) in Escherichia coli Aiche Annual Meeting, Conference Proceedings. 9086-9095. |
0.445 |
|
| 2004 |
O'Reilly L, Bross P, Corydon TJ, Olpin SE, Hansen J, Kenney JM, McCandless SE, Frazier DM, Winter V, Gregersen N, Engel PC, Andresen BS. The Y42H mutation in medium-chain acyl-CoA dehydrogenase, which is prevalent in babies identified by MS/MS-based newborn screening, is temperature sensitive. European Journal of Biochemistry / Febs. 271: 4053-63. PMID 15479234 DOI: 10.1111/J.1432-1033.2004.04343.X |
0.333 |
|
| 2004 |
Busca P, Paradisi F, Moynihan E, Maguire AR, Engel PC. Enantioselective synthesis of non-natural amino acids using phenylalanine dehydrogenases modified by site-directed mutagenesis. Organic & Biomolecular Chemistry. 2: 2684-91. PMID 15351834 DOI: 10.1039/B406364C |
0.616 |
|
| 2004 |
Aherne A, Kennan A, Kenna PF, McNally N, Lloyd DG, Alberts IL, Kiang AS, Humphries MM, Ayuso C, Engel PC, Gu JJ, Mitchell BS, Farrar GJ, Humphries P. On the molecular pathology of neurodegeneration in IMPDH1-based retinitis pigmentosa. Human Molecular Genetics. 13: 641-50. PMID 14981049 DOI: 10.1093/Hmg/Ddh061 |
0.316 |
|
| 2004 |
Batoux NE, Paradisi F, Engel PC, Migaud ME. Novel nicotinamide adenine dinucleotide analogues as selective inhibitors of NAD+-dependent enzymes Tetrahedron. 60: 6609-6617. DOI: 10.1016/J.Tet.2004.05.091 |
0.617 |
|
| 2003 |
Seah SY, Britton KL, Rice DW, Asano Y, Engel PC. Kinetic analysis of phenylalanine dehydrogenase mutants designed for aliphatic amino acid dehydrogenase activity with guidance from homology-based modelling. European Journal of Biochemistry / Febs. 270: 4628-34. PMID 14622249 DOI: 10.1046/J.1432-1033.2003.03852.X |
0.489 |
|
| 2003 |
Irwin JA, Lynch SV, Coughlan S, Baker PJ, Gudmundsson HM, Alfredsson GA, Rice DW, Engel PC. Alanine dehydrogenase from the psychrophilic bacterium strain PA-43: overexpression, molecular characterization, and sequence analysis. Extremophiles : Life Under Extreme Conditions. 7: 135-43. PMID 12664266 DOI: 10.1007/S00792-002-0305-4 |
0.442 |
|
| 2003 |
Aghajanian S, Hovsepyan M, Geoghegan KF, Chrunyk BA, Engel PC. A thermally sensitive loop in clostridial glutamate dehydrogenase detected by limited proteolysis. The Journal of Biological Chemistry. 278: 1067-74. PMID 12414808 DOI: 10.1074/Jbc.M206099200 |
0.482 |
|
| 2002 |
Seah SY, Britton KL, Rice DW, Asano Y, Engel PC. Single amino acid substitution in Bacillus sphaericus phenylalanine dehydrogenase dramatically increases its discrimination between phenylalanine and tyrosine substrates. Biochemistry. 41: 11390-7. PMID 12234181 DOI: 10.1021/Bi020196A |
0.452 |
|
| 2002 |
Wang XT, Au SW, Lam VM, Engel PC. Recombinant human glucose-6-phosphate dehydrogenase. Evidence for a rapid-equilibrium random-order mechanism. European Journal of Biochemistry / Febs. 269: 3417-24. PMID 12135480 DOI: 10.1046/J.1432-1033.2002.03015.X |
0.406 |
|
| 2002 |
Hayden BM, Bonete MJ, Brown PE, Moir AJ, Engel PC. Glutamate dehydrogenase of Halobacterium salinarum: evidence that the gene sequence currently assigned to the NADP+-dependent enzyme is in fact that of the NAD+-dependent glutamate dehydrogenase. Fems Microbiology Letters. 211: 37-41. PMID 12052548 DOI: 10.1111/J.1574-6968.2002.Tb11200.X |
0.389 |
|
| 2002 |
Dunlevy GA, Engel P. Investigations into the allosteric mechanism of a trimeric mutant of Clostridial glutamate dehydrogenase Biochemical Society Transactions. 30: A32-A32. DOI: 10.1042/Bst030A032A |
0.428 |
|
| 2001 |
Goyal A, Wang XG, Engel PC. Allosteric behaviour of 1:5 hybrids of mutant subunits of Clostridium symbiosum glutamate dehydrogenase differing in their amino acid specificity. The Biochemical Journal. 360: 651-6. PMID 11736656 DOI: 10.1042/0264-6021:3600651 |
0.471 |
|
| 2001 |
Wang XG, Britton KL, Stillman TJ, Rice DW, Engel PC. Conversion of a glutamate dehydrogenase into methionine/norleucine dehydrogenase by site-directed mutagenesis. European Journal of Biochemistry / Febs. 268: 5791-9. PMID 11722565 DOI: 10.1046/J.0014-2956.2001.02523.X |
0.467 |
|
| 2001 |
Irwin JA, Alfredsson GA, Lanzetti AJ, Gudmundsson HM, Engel PC. Purification and characterisation of a serine peptidase from the marine psychrophile strain PA-43. Fems Microbiology Letters. 201: 285-90. PMID 11470375 DOI: 10.1111/J.1574-6968.2001.Tb10770.X |
0.409 |
|
| 2001 |
Irwin JA, Gudmundsson HM, Marteinsson VT, Hreggvidsson GO, Lanzetti AJ, Alfredsson GA, Engel PC. Characterization of alanine and malate dehydrogenases from a marine psychrophile strain PA-43. Extremophiles : Life Under Extreme Conditions. 5: 199-211. PMID 11453464 DOI: 10.1007/S007920100191 |
0.437 |
|
| 2001 |
Coughlan S, Wang XG, Britton KL, Stillman TJ, Rice DW, Chiaraluce R, Consalvi V, Scandurra R, Engel PC. Contribution of an aspartate residue, D114, in the active site of clostridial glutamate dehydrogenase to the enzyme's unusual pH dependence. Biochimica Et Biophysica Acta. 1544: 10-7. PMID 11341912 DOI: 10.1016/S0167-4838(00)00200-4 |
0.477 |
|
| 2001 |
Hayden BM, Engel PC. Construction, separation and properties of hybrid hexamers of glutamate dehydrogenase in which five of the six subunits are contributed by the catalytically inert D165S. European Journal of Biochemistry / Febs. 268: 1173-80. PMID 11231268 DOI: 10.1046/J.1432-1327.2001.01949.X |
0.459 |
|
| 2001 |
Hayden B, Bonete M, Engel P. Glutamate dehydrogenase from the halophilic organism Halobacterium halobium Biochemical Society Transactions. 29: A125-A125. DOI: 10.1042/Bst029A125A |
0.364 |
|
| 2001 |
O'Reilly S, Maguire A, Kalsey S, Engel P. Characterisation of Phenylalanine Dehydrogenase with chemically synthesised non-natural amino acids Biochemical Society Transactions. 29: A119-A119. DOI: 10.1042/Bst029A119 |
0.335 |
|
| 2000 |
Parker A, Engel PC. Preliminary evidence for the existence of specific functional assemblies between enzymes of the beta-oxidation pathway and the respiratory chain. The Biochemical Journal. 345: 429-35. PMID 10642498 DOI: 10.1042/Bj3450429 |
0.345 |
|
| 2000 |
O'Reilly L, Andresen B, Gregersen N, Engel P. Medium Chain Acyl-CoA Dehydrogenase Deficiency Biochemical Society Transactions. 28: A73-A73. DOI: 10.1042/Bst028A073B |
0.318 |
|
| 2000 |
Griffin J, Engel P. Examination of coenzyme specificity in clostridial glutamate dehydrogenase by site-directed mutagenesis Biochemical Society Transactions. 28: A73-A73. DOI: 10.1042/Bst028A073A |
0.396 |
|
| 2000 |
Engel PC. A tale of terminology Trends in Biochemical Sciences. 25: 457. DOI: 10.1016/S0968-0004(00)01611-X |
0.327 |
|
| 1999 |
Parker A, Engel PC. 5,5'-Dithiobis-(2-nitrobenzoic acid) as a probe for a non-essential cysteine residue at the medium chain acyl-coenzyme A dehydrogenase binding site of the human 'electron transferring flavoprotein' (ETF). Journal of Enzyme Inhibition. 14: 381-90. PMID 10488248 DOI: 10.3109/14756369909030330 |
0.435 |
|
| 1999 |
Hayden BM, Dean JL, Martin SR, Engel PC. Chemical rescue of the catalytically disabled clostridial glutamate dehydrogenase mutant D165S by fluoride ion. The Biochemical Journal. 340: 555-60. PMID 10333502 DOI: 10.1042/Bj3400555 |
0.443 |
|
| 1999 |
Aghajanian S, Walsh TP, Engel PC. Specificity of coenzyme analogues and fragments in promoting or impeding the refolding of clostridial glutamate dehydrogenase. Protein Science : a Publication of the Protein Society. 8: 866-72. PMID 10211832 DOI: 10.1110/Ps.8.4.866 |
0.441 |
|
| 1999 |
Stillman TJ, Migueis AM, Wang XG, Baker PJ, Britton KL, Engel PC, Rice DW. Insights into the mechanism of domain closure and substrate specificity of glutamate dehydrogenase from Clostridium symbiosum. Journal of Molecular Biology. 285: 875-85. PMID 9878450 DOI: 10.1006/Jmbi.1998.2335 |
0.503 |
|
| 1998 |
Irwin JA, Alfredsson GA, Gudmundsson HM, Engel PC. Purification and properties of psychrophilic dehydrogenases. Biochemical Society Transactions. 26: S72. PMID 10909830 DOI: 10.1042/Bst026S072 |
0.304 |
|
| 1998 |
Goyal A, Aghajanian S, Hayden BM, Wang XG, Engel PC. Construction and investigation of co-operativity in hybrids of norleucine- and glutamate-active subunits of clostridial glutamate dehydrogenase. Biochemical Society Transactions. 26: S27. PMID 10909785 DOI: 10.1042/Bst026S027 |
0.394 |
|
| 1998 |
Aghajanian S, Hovsepyan M, Geoghegan KF, Chrunyk BA, Engel PC. Probing the stability of the tertiary structure of glutamate dehydrogenase by limited proteolysis. Biochemical Society Transactions. 26: S26. PMID 10909784 DOI: 10.1042/Bst026S026 |
0.372 |
|
| 1998 |
Goyal A, Wang XG, Engel PC. Patterns of activation of the norleucine activity of a quadruple mutant derived from clostridial glutamate dehydrogenase. Biochemical Society Transactions. 26: S380. PMID 10047894 DOI: 10.1042/Bst026S380 |
0.382 |
|
| 1998 |
Scandurra R, Consalvi V, Chiaraluce R, Politi L, Engel PC. Protein thermostability in extremophiles. Biochimie. 80: 933-41. PMID 9893953 DOI: 10.1016/S0300-9084(00)88890-2 |
0.301 |
|
| 1998 |
Broadway NM, Engel PC. Novel methylenecyclopropyl-based acyl-CoA dehydrogenase inhibitor. Febs Letters. 437: 122-6. PMID 9804184 DOI: 10.1016/S0014-5793(98)01155-7 |
0.396 |
|
| 1998 |
Aghajanian S, Engel PC. Use of protein engineering to explore subunit interactions in an allosteric enzyme: construction of inter-subunit hybrids in Clostridium symbiosum glutamate dehydrogenase. Protein Engineering. 11: 569-75. PMID 9740375 DOI: 10.1093/Protein/11.7.569 |
0.439 |
|
| 1998 |
Millevoi S, Pasquo A, Chiaraluce R, Consalvi V, Giangiacomo L, Britton KL, Stillman TJ, Rice DW, Engel PC. A monomeric mutant of Clostridium symbiosum glutamate dehydrogenase: comparison with a structured monomeric intermediate obtained during refolding. Protein Science : a Publication of the Protein Society. 7: 966-74. PMID 9568903 DOI: 10.1002/Pro.5560070414 |
0.421 |
|
| 1998 |
Basso LA, Engel PC, Walmsley AR. Cooperativity between trimers of the hexameric glutamate dehydrogenase from Clostridium symbiosum. Biochimica Et Biophysica Acta. 1382: 345-50. PMID 9540807 DOI: 10.1016/S0167-4838(97)00107-6 |
0.43 |
|
| 1998 |
Britton KL, Stillman TJ, Yip KS, Forterre P, Engel PC, Rice DW. Insights into the molecular basis of salt tolerance from the study of glutamate dehydrogenase from Halobacterium salinarum. The Journal of Biological Chemistry. 273: 9023-30. PMID 9535890 DOI: 10.1074/Jbc.273.15.9023 |
0.401 |
|
| 1998 |
Etchegaray A, Dieckmann R, Engel PC, Turner G, von Döhren H. Group specific antibodies against the putative AMP-binding domain signature SGTTGXPKG in peptide synthetases and related enzymes. Biochemistry and Molecular Biology International. 44: 235-43. PMID 9530507 DOI: 10.1080/15216549800201262 |
0.407 |
|
| 1997 |
Baker PJ, Waugh ML, Wang XG, Stillman TJ, Turnbull AP, Engel PC, Rice DW. Determinants of substrate specificity in the superfamily of amino acid dehydrogenases. Biochemistry. 36: 16109-15. PMID 9405044 DOI: 10.1021/Bi972024X |
0.507 |
|
| 1997 |
Goyal A, Aghajanian S, Hayden BM, Wang XG, Engel PC. Intersubunit communication in hybrid hexamers of K89L/A163G/S380A and C320S mutants of glutamate dehydrogenase from Clostridium symbiosum. Biochemistry. 36: 15000-5. PMID 9398225 DOI: 10.1021/Bi971419D |
0.478 |
|
| 1997 |
Aghajanian S, Engel PC. Re-activation of Clostridium symbiosum glutamate dehydrogenase from subunits denatured by urea. The Biochemical Journal. 326: 649-55. PMID 9307012 DOI: 10.1042/Bj3260649 |
0.479 |
|
| 1997 |
Basso LA, Engel PC, Walmsley AR. Kinetic studies on the binding of 1,N6-etheno-NAD+ to glutamate dehydrogenase from Clostridium symbiosum. Biochimica Et Biophysica Acta. 1340: 63-71. PMID 9217015 DOI: 10.1016/S0167-4838(97)00032-0 |
0.44 |
|
| 1997 |
Dean JL, Cölfen H, Harding SE, Rice DW, Engel PC. Alteration of the quaternary structure of glutamate dehydrogenase from Clostridium symbiosum by a single mutation distant from the subunit interfaces. European Biophysics Journal : Ebj. 25: 417-22. PMID 9188163 DOI: 10.1007/S002490050055 |
0.479 |
|
| 1997 |
Aghajanian SA, Engel PC. The role and importance of different fragments of NAD+ in refolding of Clostridium symbiosum glutamate dehydrogenase. Biochemical Society Transactions. 25: 56S. PMID 9056954 DOI: 10.1042/Bst025056S |
0.411 |
|
| 1996 |
Pasquo A, Britton KL, Stillman TJ, Rice DW, Cölfen H, Harding SE, Scandurra R, Engel PC. Construction of a dimeric form of glutamate dehydrogenase from Clostridium symbiosum by site-directed mutagenesis. Biochimica Et Biophysica Acta. 1297: 149-58. PMID 8917616 DOI: 10.1016/S0167-4838(96)00017-9 |
0.422 |
|
| 1996 |
Coughlan S, Wang XG, Britton KL, Stillman TJ, Rice DW, Engel PC. Preliminary functional studies of mutant D114N of Clostridium symbiosum glutamate dehydrogenase. Biochemical Society Transactions. 24: 149S. PMID 8674642 DOI: 10.1042/Bst024149S |
0.409 |
|
| 1996 |
Aghajanian SA, Wang XG, Engel PC. In vitro construction of inter-subunit hybrids in Clostridium symbiosum glutamate dehydrogenase. Biochemical Society Transactions. 24: 136S. PMID 8674626 DOI: 10.1042/Bst024136S |
0.396 |
|
| 1996 |
Wang XG, Britton LK, Baker PJ, Rice DW, Engel PC. Improving the engineered activity of mutants of clostridial glutamate dehydrogenase towards monocarboxylic substrates: substitution of Ala163 with glycine. Biochemical Society Transactions. 24: 126S. PMID 8674611 DOI: 10.1042/Bst024126S |
0.425 |
|
| 1996 |
Rice DW, Yip KS, Stillman TJ, Britton KL, Fuentes A, Connerton I, Pasquo A, Scandura R, Engel PC. Insights into the molecular basis of thermal stability from the structure determination of Pyrococcus furiosus glutamate dehydrogenase. Fems Microbiology Reviews. 18: 105-17. PMID 8639325 DOI: 10.1111/J.1574-6976.1996.Tb00230.X |
0.426 |
|
| 1995 |
Yip KS, Stillman TJ, Britton KL, Artymiuk PJ, Baker PJ, Sedelnikova SE, Engel PC, Pasquo A, Chiaraluce R, Consalvi V. The structure of Pyrococcus furiosus glutamate dehydrogenase reveals a key role for ion-pair networks in maintaining enzyme stability at extreme temperatures. Structure (London, England : 1993). 3: 1147-58. PMID 8591026 DOI: 10.1016/S0969-2126(01)00251-9 |
0.438 |
|
| 1995 |
Britton KL, Baker PJ, Borges KM, Engel PC, Pasquo A, Rice DW, Robb FT, Scandurra R, Stillman TJ, Yip KS. Insights into thermal stability from a comparison of the glutamate dehydrogenases from Pyrococcus furiosus and Thermococcus litoralis. European Journal of Biochemistry / Febs. 229: 688-95. PMID 7758464 DOI: 10.1111/J.1432-1033.1995.0688J.X |
0.462 |
|
| 1995 |
Teller JK, Baker PJ, Britton KL, Engel PC, Rice DW, Stillman TJ. Correlation of intron-exon organisation with the three-dimensional structure in glutamate dehydrogenase. Biochimica Et Biophysica Acta. 1247: 231-8. PMID 7696313 DOI: 10.1016/0167-4838(94)00240-H |
0.403 |
|
| 1995 |
Seah SY, Britton KL, Baker PJ, Rice DW, Asano Y, Engel PC. Alteration in relative activities of phenylalanine dehydrogenase towards different substrates by site-directed mutagenesis. Febs Letters. 370: 93-6. PMID 7649311 DOI: 10.1016/0014-5793(95)00804-I |
0.464 |
|
| 1995 |
Wang XG, Britton KL, Baker PJ, Martin S, Rice DW, Engel PC. Alteration of the amino acid substrate specificity of clostridial glutamate dehydrogenase by site-directed mutagenesis of an active-site lysine residue. Protein Engineering. 8: 147-52. PMID 7630885 DOI: 10.1093/Protein/8.2.147 |
0.493 |
|
| 1995 |
Wang XG, Engel PC. Positive cooperativity with Hill coefficients of up to 6 in the glutamate concentration dependence of steady-state reaction rates measured with clostridial glutamate dehydrogenase and the mutant A163G at high pH. Biochemistry. 34: 11417-22. PMID 7547869 DOI: 10.1021/Bi00036A014 |
0.492 |
|
| 1995 |
Aghajanian SA, Martin SR, Engel PC. Urea-induced inactivation and denaturation of clostridial glutamate dehydrogenase: the absence of stable dimeric or trimeric intermediates. The Biochemical Journal. 311: 905-10. PMID 7487949 DOI: 10.1042/Bj3110905 |
0.462 |
|
| 1994 |
Syed SE, Hornby DP, Brown PE, Fitton JE, Engel PC. Site and significance of chemically modifiable cysteine residues in glutamate dehydrogenase of Clostridium symbiosum and the use of protection studies to measure coenzyme binding. The Biochemical Journal. 298: 107-13. PMID 8129708 DOI: 10.1042/Bj2980107 |
0.725 |
|
| 1994 |
Dean JL, Wang XG, Teller JK, Waugh ML, Britton KL, Baker PJ, Stillman TJ, Martin SR, Rice DW, Engel PC. The catalytic role of aspartate in the active site of glutamate dehydrogenase. The Biochemical Journal. 301: 13-6. PMID 8037659 DOI: 10.1042/Bj3010013 |
0.5 |
|
| 1994 |
Wang XG, Dean JL, Engel PC, Baker PJ, Britton KL, Stillman TJ, Rice DW. The changed pattern of substrate specificity in the K89L mutant of glutamate dehydrogenase of Clostridium symbiosum. Biochemical Society Transactions. 22: 320S. PMID 7821579 DOI: 10.1042/Bst022320S |
0.416 |
|
| 1994 |
Basso LA, Engel PC, Walmsley AR. Steady-state kinetics and transient studies of substrate and coenzyme analogue binding to clostridial glutamate dehydrogenase (GDH) during oxidative deamination Biochemical Society Transactions. 22: 319S. PMID 7821578 DOI: 10.1042/Bst022319S |
0.336 |
|
| 1994 |
Aghajanian SA, Engel PC. Studies of dissociation-association processes in clostridial glutamate dehydrogenase Biochemical Society Transactions. 22: 318S. PMID 7821577 DOI: 10.1042/Bst022318S |
0.365 |
|
| 1994 |
Basso LA, Engel PC. Initial formation of a non-covalent enzyme-reagent complex during the inactivation of clostridial glutamate dehydrogenase by Ellman's reagent: determination of the enzyme's dissociation constant for the binary complex with NAD+ from protection studies. Biochimica Et Biophysica Acta. 1209: 222-6. PMID 7811694 DOI: 10.1016/0167-4838(94)90188-0 |
0.464 |
|
| 1994 |
Wang XG, Engel PC. Identification of the reactive cysteine in clostridial glutamate dehydrogenase by site-directed mutagenesis and proof that this residue is not strictly essential Protein Engineering. 7: 1013-1016. PMID 7809027 DOI: 10.1093/Protein/7.8.1013 |
0.51 |
|
| 1993 |
Valinger Z, Engel PC, Metzler DE. Is pyridoxal 5'-phosphate an affinity label for phosphate-binding sites in proteins?: The case of bovine glutamate dehydrogenase. The Biochemical Journal. 294: 835-9. PMID 8379938 DOI: 10.1042/Bj2940835 |
0.457 |
|
| 1993 |
Syed SEH, Engel PC. Inhibition of glutamate dehydrogenase by covalent coenzyme-substrate adducts: A re-examination Biochemistry and Molecular Biology International. 30: 283-291. PMID 8364410 |
0.381 |
|
| 1993 |
Britton KL, Baker PJ, Engel PC, Rice DW, Stillman TJ. Evolution of substrate diversity in the superfamily of amino acid dehydrogenases: Prospects for rational chiral synthesis Journal of Molecular Biology. 234: 938-945. PMID 8263939 DOI: 10.1006/Jmbi.1993.1647 |
0.48 |
|
| 1993 |
Basso LA, Engel PC, Walmsley AR. The mechanism of substrate and coenzyme binding to clostridial glutamate dehydrogenase during oxidative deamination European Journal of Biochemistry. 213: 935-945. PMID 8099328 DOI: 10.1111/J.1432-1033.1993.Tb17838.X |
0.377 |
|
| 1993 |
Engel PC. Specificity constants for two-substrate enzymes Biochemical Journal. 291: 324-325. DOI: 10.1042/Bj2910324 |
0.44 |
|
| 1992 |
Lilley KS, Engel PC. The essential active-site lysines of clostridial glutamate dehydrogenase. A study with pyridoxal-5'-phosphate European Journal of Biochemistry. 207: 533-540. PMID 1633808 DOI: 10.1111/J.1432-1033.1992.Tb17079.X |
0.462 |
|
| 1992 |
Teller JK, Smith RJ, McPherson MJ, Engel PC, Guest JR. The glutamate dehydrogenase gene of Clostridium symbiosum. Cloning by polymerase chain reaction, sequence analysis and over-expression in Escherichia coli. European Journal of Biochemistry / Febs. 206: 151-9. PMID 1587267 DOI: 10.1111/J.1432-1033.1992.Tb16912.X |
0.43 |
|
| 1991 |
Syed SEH, Engel PC, Parker DM. Functional studies of a glutamate dehydrogenase with known three-dimensional structure: steady-state kinetics of the forward and reverse reactions catalysed by the NAD+-dependent glutamate dehydrogenase of Clostridium symbiosum Bba - General Subjects. 1115: 123-130. PMID 1764463 DOI: 10.1016/0304-4165(91)90020-H |
0.475 |
|
| 1991 |
Kølvraa S, Gregersen N, Blakemore AIF, Schneidermann AK, Winter V, Andresen BS, Curtis D, Engel PC, Pricille D, Rhead W, Bolund L. The most common mutation causing medium-chain acyl-CoA dehydrogenase deficiency is strongly associated with a particular haplotype in the region of the gene Human Genetics. 87: 425-428. PMID 1679031 DOI: 10.1007/Bf00197161 |
0.335 |
|
| 1990 |
Syed SEH, Engel PC. A pH-dependent activation-inactivation equilibrium in glutamate dehydrogenase of Clostridium symbiosum Biochemical Journal. 271: 351-355. PMID 2241920 DOI: 10.1042/Bj2710351 |
0.436 |
|
| 1990 |
Syed SEH, Engel PC, Martin SR. A circular dichroism study of the pH-dependent activation/inactivation equilibrium in the glutamate dehydrogenase of Clostridium symbiosum Febs Letters. 262: 176-178. DOI: 10.1016/0014-5793(90)80183-J |
0.33 |
|
| 1988 |
LILLEY KS, HORNBY DP, ENGEL PC. Purification, chemical modification and analysis of pH-dependence of the NADP+-dependent glutamate dehydrogenase of Escherichia coli Biochemical Society Transactions. 16: 876-877. DOI: 10.1042/Bst0160876 |
0.679 |
|
| 1988 |
LILLEY KS, ENGEL PC. Identification of three essential lysine residues probably involved in substrate binding of the NAD+ - dependent glutamate dehydrogenase of Clostridium symbiosum Biochemical Society Transactions. 16: 875-876. DOI: 10.1042/Bst0160875 |
0.459 |
|
| 1987 |
Shaw L, Engel PC. CoA-persulphide: a possible in vivo inhibitor of mammalian short-chain acyl-CoA dehydrogenase Biochimica Et Biophysica Acta (Bba)/Lipids and Lipid Metabolism. 919: 171-174. PMID 3580384 DOI: 10.1016/0005-2760(87)90204-9 |
0.442 |
|
| 1987 |
ENGEL PC, HORNBY DP. A simple method for the calibration of recording fluorimeters by kinetic means in the study of NAD(P)+-dependent dehydrogenases Biochemical Society Transactions. 15: 386-387. DOI: 10.1042/Bst0150386 |
0.602 |
|
| 1987 |
SYED SH, ENGEL PC. Glutamate dehydrogenase of Clostridium symbiosum: another example of an abrupt transition in the kinetic plots Biochemical Society Transactions. 15: 237-238. DOI: 10.1042/Bst0150237 |
0.386 |
|
| 1987 |
ELLISON PA, ENGEL PC. Does butyryl-CoA dehydrogenase catalyse thiol-thioester exchange? Biochemical Society Transactions. 15: 236-237. DOI: 10.1042/Bst0150236 |
0.394 |
|
| 1986 |
ELLISON PA, ENGEL PC. Crotonase activity in preparations of butyryl-CoA dehydrogenase from Megasphaera elsdenii Biochemical Society Transactions. 14: 158-158. DOI: 10.1042/Bst0140158 |
0.337 |
|
| 1986 |
SYED S, ENGEL PC. Reversible pH-dependent inactivation of glutamate dehydrogenase from Clostridium symbiosum Biochemical Society Transactions. 14: 157-157. DOI: 10.1042/Bst0140157 |
0.399 |
|
| 1986 |
WATERS BW, ENGEL PC, WILLIAMSON G. Photoinactivation of butyryl-CoA dehydrogenase Biochemical Society Transactions. 14: 138-139. DOI: 10.1042/Bst0140138 |
0.44 |
|
| 1985 |
Shaw L, Engel PC. The suicide inactivation of ox liver short-chain acyl-CoA dehydrogenase by propionyl-CoA. Formation of an FAD adduct Biochemical Journal. 230: 723-731. PMID 4062874 |
0.34 |
|
| 1985 |
Hornby DP, Engel PC, Hatanaka S. Kinetic studies of ox-liver glutamate dehydrogenase oxidative deamination of two glutamate analogues, L-threo-gamma-methylglutamate and L-alpha-amino-gamma-nitraminobutyrate, in the presence of the allosteric effector ADP. The International Journal of Biochemistry. 17: 851-4. PMID 4054426 DOI: 10.1016/0020-711X(85)90277-0 |
0.691 |
|
| 1985 |
Rice DW, Hornby DP, Engel PC. Crystallization of an NAD+-dependent glutamate dehydrogenase from Clostridium symbiosum. Journal of Molecular Biology. 181: 147-9. PMID 3981633 DOI: 10.1016/0022-2836(85)90334-1 |
0.649 |
|
| 1984 |
Williamson G, Engel PC. Butyryl-CoA dehydrogenase from Megasphaera elsdenii. Specificity of the catalytic reaction Biochemical Journal. 218: 521-529. PMID 6712628 DOI: 10.1042/Bj2180521 |
0.367 |
|
| 1984 |
Shaw L, Engel PC. The purification and properties of ox liver short-chain acyl-CoA dehydrogenase Biochemical Journal. 218: 511-520. PMID 6712627 |
0.341 |
|
| 1984 |
Hornby DP, Engel PC. Characterization of Peptostreptococcus asaccharolyticus glutamate dehydrogenase purified by dye-ligand chromatography. Journal of General Microbiology. 130: 2385-94. PMID 6502134 DOI: 10.1099/00221287-130-9-2385 |
0.723 |
|
| 1984 |
Hornby DP, Aitchison MJ, Engel PC. The kinetic mechanism of ox liver glutamate dehydrogenase in the presence of the allosteric effector ADP. The oxidative deamination of L-glutamate. The Biochemical Journal. 223: 161-8. PMID 6149744 DOI: 10.1042/Bj2230161 |
0.713 |
|
| 1984 |
Syed SE, Engel PC. Ox liver glutamate dehydrogenase. The use of chemical modification to study the relationship between catalytic sites for different amino acid substrates and the question of kinetic non-equivalence of the subunits Biochemical Journal. 222: 621-626. PMID 6148932 |
0.399 |
|
| 1984 |
Hornby DP, Engel PC. A kinetic study of the oxidative deamination of L-glutamate by Peptostreptococcus asaccharolyticus glutamate dehydrogenase using a variety of coenzymes. European Journal of Biochemistry / Febs. 143: 557-60. PMID 6148240 DOI: 10.1111/J.1432-1033.1984.Tb08405.X |
0.715 |
|
| 1984 |
Engel PC. Chapter 3 Enzyme kinetics New Comprehensive Biochemistry. 6: 73-110. DOI: 10.1016/S0167-7306(08)60374-9 |
0.425 |
|
| 1983 |
Williamson G, Engel PC. The effect on butyryl-CoA dehydrogenase of reagents specific for nucleophilic sulphur Biochemical Journal. 211: 559-566. PMID 6882359 DOI: 10.1042/Bj2110559 |
0.425 |
|
| 1983 |
Hornby DP, Engel PC, Hatanaka S. Beef liver glutamate dehydrogenase: a study of the oxidation of various alternative amino acid substrates retaining the correct spacing of the two carboxylate groups. The International Journal of Biochemistry. 15: 495-500. PMID 6852348 DOI: 10.1016/0020-711X(83)90122-2 |
0.696 |
|
| 1983 |
Aitchison MJ, Engel PC. Beef liver glutamate dehydrogenase : Effects of partial proteolysis with chymotrypsin International Journal of Biochemistry. 15: 79-85. PMID 6825906 DOI: 10.1016/0020-711X(83)90014-9 |
0.422 |
|
| 1983 |
HORNBY DP, ENGEL PC. The coenzyme specificity of glutamate dehydrogenase from Peptococcus asaccharolyticus Biochemical Society Transactions. 11: 175-176. DOI: 10.1042/Bst0110175 |
0.684 |
|
| 1982 |
Williamson G, Engel PC. A convenient and rapid method for the complete removal of CoA from butyryl-CoA dehydrogenase Biochimica Et Biophysica Acta (Bba)/Protein Structure and Molecular. 706: 245-248. PMID 7126602 DOI: 10.1016/0167-4838(82)90493-9 |
0.422 |
|
| 1982 |
Williamson G, Engel PC, Nishina Y, Shiga K. A resonance Raman study on the nature of charge-transfer interactions in butyryl CoA dehydrogenase. Febs Letters. 138: 29-32. PMID 7067828 DOI: 10.1016/0014-5793(82)80387-6 |
0.404 |
|
| 1982 |
Gould KG, Engel PC. The reactions of pyridoxal 5′-phosphate with the M4 and H4 isoenzymes of pig lactate dehydrogenase Archives of Biochemistry and Biophysics. 215: 498-507. PMID 6807212 DOI: 10.1016/0003-9861(82)90108-4 |
0.396 |
|
| 1981 |
Engel PC. [43] Butyryl-CoA dehydrogenase from Megasphaera elsdenii. EC 1.3.99.2 butyryl-CoA:(acceptor) oxidoreductase Methods in Enzymology. 71: 359-366. DOI: 10.1016/0076-6879(81)71045-0 |
0.314 |
|
| 1980 |
Aitchison MJ, Engel PC. The effects of digestion by bovine pancreas alpha-chymotrypsin on native bovine glutamate dehydrogenase Biochemical Society Transactions. 8: 649. PMID 7450274 DOI: 10.1042/Bst0080649 |
0.356 |
|
| 1980 |
Gould KG, Engel PC. Modification of mouse testicular lactate dehydrogenase by pyridoxal 5'-phosphate Biochemical Journal. 191: 365-371. PMID 6786279 |
0.371 |
|
| 1979 |
Gould KG, Engel PC. A re-examination of the reaction between Ox liver glutamate dehydrogenase and 1-fluoro-2,4-dinitrobenzene Archives of Biochemistry and Biophysics. 196: 284-294. PMID 41482 DOI: 10.1016/0003-9861(79)90578-2 |
0.44 |
|
| 1978 |
Gould KG, Engel PC. Desensitization of bovine liver glutamate dehydrogenase by 1-fluoro-2,4-dinitrobenzene Biochemical Society Transactions. 6: 1226-1228. PMID 744394 DOI: 10.1042/Bst0061226 |
0.36 |
|
| 1978 |
Engel PC. Fatty acyl-coenzyme A dehydrogenases Biochemical Society Transactions. 6: 76-80. PMID 640208 DOI: 10.1042/Bst0060076 |
0.396 |
|
| 1978 |
Engel PC, Jones JB. Causes and elimination of erratic blanks in enzymatic metabolite assays involving the use of NAD+ in alkaline hydrazine buffers: Improved conditions for the assay of l-glutamate, l-lactate, and other metabolites Analytical Biochemistry. 88: 475-484. PMID 29519 DOI: 10.1016/0003-2697(78)90447-5 |
0.351 |
|
| 1978 |
Engel PC, Jones JB. A reappraisal of the reaction of butyryl-coenzyme A dehydrogenase with phenylmercuric acetate. Evidence that de-greening involves a reaction of the tightly bound thioester Biochemical Journal. 171: 51-59. PMID 25661 DOI: 10.1042/Bj1710051 |
0.455 |
|
| 1977 |
Chen SS, Engel PC, Bayley PM. The allosteric mechanism of bovine liver glutamate dehydrogenase. Evidence from circular dichroism studies for a conformational change in the ternary complex enzyme (oxidized nicotinamide adenine dinucleotide) glutarate Biochemical Journal. 163: 297-302. PMID 194583 |
0.384 |
|
| 1977 |
Dickinson FM, Engel PC. The preparation of pure salt-free nicotinamide coenzymes Analytical Biochemistry. 82: 523-531. PMID 20816 DOI: 10.1016/0003-2697(77)90191-9 |
0.313 |
|
| 1977 |
ENGEL PC. Initial Rate Enzyme Kinetics Biochemical Society Transactions. 5: 332-332. DOI: 10.1042/Bst0050332 |
0.395 |
|
| 1975 |
Chen SS, Engel PC. Modification of pig M4 lactate dehydrogenase by pyridoxal 5 phosphate. Demonstration of an essential lysine residue Biochemical Journal. 149: 107-113. PMID 1238085 DOI: 10.1042/Bj1490107 |
0.483 |
|
| 1975 |
Chen SS, Engel PC. The equilibrium position of the reaction of bovine liver glutamate dehydrogenase with pyridoxal 5' phosphate. A demonstration that covalent modification with this reagent completely abolishes catalytic activity Biochemical Journal. 147: 351-358. PMID 1237292 |
0.375 |
|
| 1975 |
Engel PC, Chen SS. The nature of inhibition and inactivation of bovine liver glutamate dehydrogenase by pyridoxal 5' phosphate Biochemical Society Transactions. 3: 78-80. PMID 1126546 DOI: 10.1042/Bst0030078 |
0.369 |
|
| 1975 |
Engel PC, Chen SS. A product inhibition study of bovine liver glutamate dehydrogenase Biochemical Journal. 151: 305-318. PMID 175778 |
0.327 |
|
| 1975 |
Chen SS, Engel PC. Reversible modification of pig heart mitochondrial malate dehydrogenase by pyridoxal 5' phosphate Biochemical Journal. 151: 297-303. PMID 175777 |
0.327 |
|
| 1975 |
Chen SS, Engel PC. Horse liver alcohol dehydrogenase. A study of the essential lysine residue Biochemical Journal. 149: 627-635. PMID 173294 DOI: 10.1042/Bj1490627 |
0.476 |
|
| 1975 |
Chen SS, Engel PC. Ox liver glutamate dehydrogenase. The role of lysine 126 reappraised in the light of studies of inhibition and inactivation by pyridoxal 5' phosphate Biochemical Journal. 149: 619-626. PMID 173293 DOI: 10.1042/Bj1490619 |
0.463 |
|
| 1975 |
Chen SS, Engel PC. Inactivation of nicotinamide adenine dinucleotide linked dehydrogenases by pyridoxal 5' phosphate Biochemical Society Transactions. 3: 80-82. PMID 165109 DOI: 10.1042/Bst0030080 |
0.409 |
|
| 1975 |
Chen SS, Engel PC. Equilibrium protection studies of the interaction of bovine glutamate dehydrogenase with purine nucleotide effectors Febs Letters. 58: 202-206. PMID 5298 DOI: 10.1016/0014-5793(75)80259-6 |
0.401 |
|
| 1974 |
Chen SS, Engel PC. Protection of glutamate dehydrogenase by nicotinamide adenine dinucleotide against reversible inactivation by pyridoxal 5' phosphate as a sensitive indicator of conformational change induced by substrates and substrate analogues Biochemical Journal. 143: 569-574. PMID 4376949 DOI: 10.1042/Bj1430569 |
0.506 |
|
| 1973 |
Engel PC. Evolution of enzyme regulator sites: Evidence for partial gene duplication from amino-acid sequence of bovine glutamate dehydrogenase [11] Nature. 241: 118-120. PMID 4695538 DOI: 10.1038/241118a0 |
0.339 |
|
| 1973 |
Engel PC. Sequence homologies among pyridine nucleotide-linked dehydrogenases: Possible partial gene duplications in glyceraldehyde-3-phosphate dehydrogenase Febs Letters. 33: 151-153. PMID 4578953 DOI: 10.1016/0014-5793(73)80181-4 |
0.308 |
|
| 1973 |
Engel PC, Ferdinand W. The significance of abrupt transitions in Lineweaver-Burk plots with particular reference to glutamate dehydrogenase. Negative and positive co-operativity in catalytic rate constants Biochemical Journal. 131: 97-105. PMID 4352866 DOI: 10.1042/Bj1310097 |
0.414 |
|
| 1971 |
Engel PC, Massey V. Green butyryl-coenzyme A dehydrogenase. An enzyme-acyl-coenzyme A complex Biochemical Journal. 125: 889-902. PMID 5145911 DOI: 10.1042/Bj1250889 |
0.629 |
|
| 1971 |
Engel PC, Massey V. The purification and properties of butyryl-coenzyme A dehydrogenase from Peptostreptococcus elsdenii Biochemical Journal. 125: 879-887. PMID 5145910 DOI: 10.1042/Bj1250879 |
0.614 |
|
| 1970 |
Engel PC, Dalziel K. Kinetic studies of glutamate dehydrogenase. The reductive amination of 2-oxoglutarate. The Biochemical Journal. 118: 409-19. PMID 4394334 DOI: 10.1042/Bj1180409 |
0.668 |
|
| 1969 |
Massey V, Strickland S, Mayhew SG, Howell LG, Engel PC, Matthews RG, Schuman M, Sullivan PA. The production of superoxide anion radicals in the reaction of reduced flavins and flavoproteins with molecular oxygen. Biochemical and Biophysical Research Communications. 36: 891-7. PMID 5388670 DOI: 10.1016/0006-291X(69)90287-3 |
0.683 |
|
| 1969 |
Engel PC, Dalziel K. Kinetic studies of glutamate dehydrogenase with glutamate and norvaline as substrates. Coenzyme activation and negative homotropic interactions in allosteric enzymes. The Biochemical Journal. 115: 621-31. PMID 4391040 DOI: 10.1042/Bj1150621 |
0.689 |
|
| 1968 |
Dalziel K, Engel PC. Antagonistic homotropic interactions as a possible explanation of coenzyme activation of glutamate dehydrogenase. Febs Letters. 1: 349-352. PMID 11945341 DOI: 10.1016/0014-5793(68)80153-X |
0.621 |
|
| 1967 |
Engel PC, Dalziel K. The equilibrium constants of the glutamate dehydrogenase systems. The Biochemical Journal. 105: 691-5. PMID 4384597 DOI: 10.1042/Bj1050691 |
0.603 |
|
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