James Dowden, Ph.D - Publications

1996-1999 Chemistry University of Edinburgh, Edinburgh, Scotland, United Kingdom 
 1999-2005 Chemistry University of Bath, Bath, England, United Kingdom 
 2005- Chemistry University of Nottingham, Nottingham, England, United Kingdom 
Natural product synthesis, Biochemistry

17 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Gunnell EA, Al-Noori A, Muhsen U, Davies CC, Dowden J, Dreveny I. Structural and biochemical evaluation of bisubstrate inhibitors of protein arginine N-methyltransferases PRMT1 and CARM1 (PRMT4). The Biochemical Journal. PMID 32011657 DOI: 10.2210/Pdb6S7C/Pdb  0.588
2011 Dowden J, Pike RA, Parry RV, Hong W, Muhsen UA, Ward SG. Small molecule inhibitors that discriminate between protein arginine N-methyltransferases PRMT1 and CARM1. Organic & Biomolecular Chemistry. 9: 7814-21. PMID 21952734 DOI: 10.1039/C1Ob06100C  0.592
2011 Hong W, Dowden J. Facile synthesis of N-6 adenosine modified analogue toward S-adenosyl methionine derived probe for protein arginine methyltransferases Chinese Chemical Letters. 22: 1439-1442. DOI: 10.1016/J.Cclet.2011.09.007  0.449
2010 Dowden J, Hong W, Parry RV, Pike RA, Ward SG. Toward the development of potent and selective bisubstrate inhibitors of protein arginine methyltransferases. Bioorganic & Medicinal Chemistry Letters. 20: 2103-5. PMID 20219369 DOI: 10.1016/J.Bmcl.2010.02.069  0.435
2010 Stevenson B, Lewis W, Dowden J. Expedient route to an amine precursor of halichlorine and pinnaic acid from nitrocyclopent-1-ene Synlett. 672-674. DOI: 10.1055/S-0029-1219337  0.344
2007 Foster SR, Pearce A, Blake AJ, Welham MJ, Dowden J. Novel octavalent cross-linker displays efficient trapping of protein-protein interactions. Chemical Communications (Cambridge, England). 2512-4. PMID 17563813 DOI: 10.1039/B701542A  0.309
2007 Parkesh R, Vasudevan SR, Berry A, Galione A, Dowden J, Churchill GC. Chemo-enzymatic synthesis and biological evaluation of photolabile nicotinic acid adenine dinuclotide phosphate (NAADP+). Organic & Biomolecular Chemistry. 5: 441-3. PMID 17252124 DOI: 10.1039/B617344F  0.38
2007 Anderson C, Bartlett SJ, Gansner JM, Wilson D, He L, Gitlin JD, Kelsh RN, Dowden J. Chemical genetics suggests a critical role for lysyl oxidase in zebrafish notochord morphogenesis. Molecular Biosystems. 3: 51-9. PMID 17216056 DOI: 10.1039/B613673G  0.334
2006 Dowden J, Berridge G, Moreau C, Yamasaki M, Churchill GC, Potter BV, Galione A. Cell-permeant small-molecule modulators of NAADP-mediated Ca2+ release. Chemistry & Biology. 13: 659-65. PMID 16793523 DOI: 10.1016/J.Chembiol.2006.05.005  0.306
2005 Dowden J, Brown RS, Moreau C, Galione A, Potter BV. Chemical synthesis of the novel Ca2+ messenger NAADP. Nucleosides, Nucleotides & Nucleic Acids. 24: 513-8. PMID 16247981 DOI: 10.1081/Ncn-200061786  0.333
2004 Dowden J, Moreau C, Brown RS, Berridge G, Galione A, Potter BV. Chemical synthesis of the second messenger nicotinic acid adenine dinucleotide phosphate by total synthesis of nicotinamide adenine dinucleotide phosphate. Angewandte Chemie (International Ed. in English). 43: 4637-40. PMID 15352191 DOI: 10.1002/Anie.200460054  0.326
2003 Ward S, Sotsios Y, Dowden J, Bruce I, Finan P. Therapeutic potential of phosphoinositide 3-kinase inhibitors. Chemistry & Biology. 10: 207-13. PMID 12670534 DOI: 10.1016/S1074-5521(03)00048-6  0.388
2001 Dowden J, Ward SG. Inhibitors of p56Ick: Assessing their potential as tools for manipulating T-lymphocte activation Expert Opinion On Therapeutic Patents. 11: 295-306. DOI: 10.1517/13543776.11.2.295  0.447
1999 Taylor P, Anderson V, Dowden J, Flitsch SL, Turner NJ, Loughran K, Walkinshaw MD. Novel mechanism of inhibition of elastase by beta-lactams is defined by two inhibitor crystal complexes. The Journal of Biological Chemistry. 274: 24901-5. PMID 10455164 DOI: 10.1074/Jbc.274.35.24901  0.355
1999 Dowden J, Edwards PD, Flack SS, Kilburn JD. Synthesis and binding properties of a macrocyclic peptide receptor Chemistry - a European Journal. 5: 79-89. DOI: 10.1002/(Sici)1521-3765(19990104)5:1<79::Aid-Chem79>3.0.Co;2-W  0.602
1997 Dowden J, Edwards PD, Kilburn JD. Modified synthesis and binding properties of a peptide receptor Tetrahedron Letters. 38: 1095-1098. DOI: 10.1016/S0040-4039(97)00068-3  0.606
1995 Dowden J, Kilburn JD, Wright P. Synthetic developments in host-guest chemistry Contemporary Organic Synthesis. 2: 289-314. DOI: 10.1039/Co9970400061  0.521
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