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John F. W. Keana - Publications

Affiliations: 
1965- University of Oregon, Eugene, OR, United States 
Website:
https://chemistry.uoregon.edu/profile/jkeana/
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32 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2003 Birrell GB, Zaikova TO, Rukavishnikov AV, Keana JF, Griffith OH. Allosteric interactions within subsites of a monomeric enzyme: kinetics of fluorogenic substrates of PI-specific phospholipase C. Biophysical Journal. 84: 3264-75. PMID 12719256 DOI: 10.1016/S0006-3495(03)70051-4  0.38
2003 Zhou ZL, Kher SM, Cai SX, Whittemore ER, Espitia SA, Hawkinson JE, Tran M, Woodward RM, Weber E, Keana JF. Synthesis and SAR of novel di- and trisubstituted 1,4-dihydroquinoxaline-2,3-diones related to licostinel (Acea 1021) as NMDA/glycine site antagonists. Bioorganic & Medicinal Chemistry. 11: 1769-80. PMID 12659763 DOI: 10.1016/S0968-0896(03)00059-2  0.41
2002 Ryan M, Zaikova TO, Keana JF, Goldfine H, Griffith OH. Listeria monocytogenes phosphatidylinositol-specific phospholipase C: activation and allostery. Biophysical Chemistry. 101: 347-58. PMID 12488013 DOI: 10.1016/S0301-4622(02)00158-8  0.353
2001 Zhou ZL, Navratil JM, Cai SX, Whittemore ER, Espitia SA, Hawkinson JE, Tran M, Woodward RM, Weber E, Keana JF. Synthesis and SAR of 5-, 6-, 7- and 8-aza analogues of 3-aryl-4-hydroxyquinolin-2(1H)-one as NMDA/glycine site antagonists. Bioorganic & Medicinal Chemistry. 9: 2061-71. PMID 11504642 DOI: 10.1016/S0968-0896(01)00115-8  0.392
2000 Guzikowski AP, Tamiz AP, Acosta-Burruel M, Hong-Bae S, Cai SX, Hawkinson JE, Keana JF, Kesten SR, Shipp CT, Tran M, Whittemore ER, Woodward RM, Wright JL, Zhou ZL. Synthesis of N-substituted 4-(4-hydroxyphenyl)piperidines, 4-(4-hydroxybenzyl)piperidines, and (+/-)-3-(4-hydroxyphenyl)pyrrolidines: selective antagonists at the 1A/2B NMDA receptor subtype. Journal of Medicinal Chemistry. 43: 984-94. PMID 10715162 DOI: 10.1021/Jm990428C  0.362
1999 Tamiz AP, Cai SX, Zhou ZL, Yuen PW, Schelkun RM, Whittemore ER, Weber E, Woodward RM, Keana JF. Structure-activity relationship of N-(phenylalkyl)cinnamides as novel NR2B subtype-selective NMDA receptor antagonists. Journal of Medicinal Chemistry. 42: 3412-20. PMID 10464027 DOI: 10.1021/Jm990199U  0.366
1999 Zhou ZL, Cai SX, Whittemore ER, Konkoy CS, Espitia SA, Tran M, Rock DM, Coughenour LL, Hawkinson JE, Boxer PA, Bigge CF, Wise LD, Weber E, Woodward RM, Keana JF. 4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: a novel, potent, and selective NR1/2B NMDA receptor antagonist. Journal of Medicinal Chemistry. 42: 2993-3000. PMID 10425109 DOI: 10.1021/Jm990246I  0.39
1999 Rukavishnikov AV, Zaikova TO, Birrell GB, Keana JF, Griffith OH. Synthesis of a new fluorogenic substrate for the continuous assay of mammalian phosphoinositide-specific phospholipase C. Bioorganic & Medicinal Chemistry Letters. 9: 1133-6. PMID 10328299 DOI: 10.1016/S0960-894X(99)00166-3  0.357
1998 Wang Y, Konkoy CS, Ilyin VI, Vanover KE, Carter RB, Weber E, Keana JF, Woodward RM, Cai SX. Synthesis of 7,8-(methylenedioxy)-1-phenyl-3,5-dihydro-4H-2, 3-benzodiazepin-4-ones as novel and potent noncompetitive AMPA receptor antagonists. Journal of Medicinal Chemistry. 41: 2621-5. PMID 9651166 DOI: 10.1021/Jm980168J  0.365
1997 Rukavishnikov AV, Zaikova TO, Griffith OH, Keana JF. Improved synthesis of myo-inositol 1-(4-nitrophenyl hydrogen phosphate), a chromogenic substrate for phosphatidylinositol-specific phospholipase C. Chemistry and Physics of Lipids. 89: 153-7. PMID 9369010 DOI: 10.1016/S0009-3084(97)00069-8  0.332
1997 Cai SX, Huang JC, Espitia SA, Tran M, Ilyin VI, Hawkinson JE, Woodward RM, Weber E, Keana JF. 5-(N-oxyaza)-7-substituted-1,4-dihydroquinoxaline-2,3-diones: novel, systemically active and broad spectrum antagonists for NMDA/glycine, AMPA, and kainate receptors. Journal of Medicinal Chemistry. 40: 3679-86. PMID 9357535 DOI: 10.1021/Jm970396Y  0.383
1997 Cai SX, Kher SM, Zhou ZL, Ilyin V, Espitia SA, Tran M, Hawkinson JE, Woodward RM, Weber E, Keana JF. Structure-activity relationships of alkyl- and alkoxy-substituted 1,4-dihydroquinoxaline-2,3-diones: potent and systemically active antagonists for the glycine site of the NMDA receptor. Journal of Medicinal Chemistry. 40: 730-8. PMID 9057859 DOI: 10.1021/Jm960654B  0.4
1996 Cai SX, Zhou ZL, Huang JC, Whittemore ER, Egbuwoku ZO, Hawkinson JE, Woodward RM, Weber E, Keana JF. Structure-activity relationships of 4-hydroxy-3-nitroquinolin-2(1H)-ones as novel antagonists at the glycine site of N-methyl-D-aspartate receptors. Journal of Medicinal Chemistry. 39: 4682-6. PMID 8917657 DOI: 10.1021/Jm960520Y  0.38
1996 Guzikowski AP, Cai SX, Espitia SA, Hawkinson JE, Huettner JE, Nogales DF, Tran M, Woodward RM, Weber E, Keana JF. Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: structure-activity relationship at N-methyl-D-aspartate receptor glycine sites. Journal of Medicinal Chemistry. 39: 4643-53. PMID 8917653 DOI: 10.1021/Jm960479Z  0.437
1996 Ryan M, Smith MP, Vinod TK, Lau WL, Keana JF, Griffith OH. Synthesis, structure-activity relationships, and the effect of polyethylene glycol on inhibitors of phosphatidylinositol-specific phospholipase C from Bacillus cereus. Journal of Medicinal Chemistry. 39: 4366-76. PMID 8893831 DOI: 10.1021/Jm960434Y  0.357
1996 Cai SX, Zhou ZL, Huang JC, Whittemore ER, Egbuwoku ZO, Lü Y, Hawkinson JE, Woodward RM, Weber E, Keana JF. Synthesis and structure-activity relationships of 1,2,3,4-tetrahydroquinoline-2,3,4-trione 3-oximes: novel and highly potent antagonists for NMDA receptor glycine site. Journal of Medicinal Chemistry. 39: 3248-55. PMID 8765507 DOI: 10.1021/Jm960214K  0.396
1996 Heinz DW, Ryan M, Smith MP, Weaver LH, Keana JF, Griffith OH. Crystal structure of phosphatidylinositol-specific phospholipase C from Bacillus cereus in complex with glucosaminyl(alpha 1-->6)-D-myo-inositol, an essential fragment of GPI anchors. Biochemistry. 35: 9496-504. PMID 8755729 DOI: 10.1021/Bi9606105  0.35
1995 Warner DS, Martin H, Ludwig P, McAllister A, Keana JF, Weber E. In vivo models of cerebral ischemia: effects of parenterally administered NMDA receptor glycine site antagonists. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 15: 188-96. PMID 7860652 DOI: 10.1038/Jcbfm.1995.24  0.312
1994 Phadke AS, Aggeler R, Keana JF, Capaldi RA. TFPACD, a novel bifunctional reagent for reacting with DCCD sites in proteins: studies using Escherichia coli ATP synthase. Biochemical and Biophysical Research Communications. 201: 635-41. PMID 8002996 DOI: 10.1006/Bbrc.1994.1748  0.303
1994 Vinod TK, Hayes Griffith O, Keana JF. Synthesis of isosteric and isopolar phosphonate substrate analogues designed as inhibitors for phosphatidylinositol-specific phospholipase C from bacillus cereus Tetrahedron Letters. 35: 7193-7196. DOI: 10.1016/0040-4039(94)85358-4  0.357
1993 Gee KR, Durant GJ, Holmes DL, Magar SS, Weber E, Wong ST, Keana JF. N-(3-azidophenyl)-N-methyl-N'-([4-1H]- and [4-3H]-1-naphthyl)guanidine. A potent and selective ligand designed as a photoaffinity label for the phencyclidine site of the N-methyl-D-aspartate receptor. Bioconjugate Chemistry. 4: 226-9. PMID 8324013 DOI: 10.1021/Bc00021A007  0.332
1993 Ryan M, Huang JC, Griffith OH, Keana JF, Volwerk JJ. A chemiluminescent substrate for the detection of phosphatidylinositol-specific phospholipase C. Analytical Biochemistry. 214: 548-56. PMID 8109748 DOI: 10.1006/Abio.1993.1537  0.331
1992 Leigh AJ, Volwerk JJ, Griffith OH, Keana JF. Substrate stereospecificity of phosphatidylinositol-specific phospholipase C from Bacillus cereus examined using the resolved enantiomers of synthetic myo-inositol 1-(4-nitrophenyl phosphate). Biochemistry. 31: 8978-83. PMID 1327107 DOI: 10.1021/Bi00152A039  0.341
1991 Shashidhar MS, Volwerk JJ, Griffith OH, Keana JF. A chromogenic substrate for phosphatidylinositol-specific phospholipase C: 4-nitrophenyl myo-inositol-1-phosphate. Chemistry and Physics of Lipids. 60: 101-10. PMID 1814635 DOI: 10.1016/0009-3084(91)90032-7  0.361
1991 Shashidhar MS, Volwerk JJ, Keana JF, Griffith OH. A fluorescent substrate for the continuous assay of phosphatidylinositol-specific phospholipase C: synthesis and application of 2-naphthyl myo-inositol-1-phosphate. Analytical Biochemistry. 198: 10-4. PMID 1789410 DOI: 10.1016/0003-2697(91)90498-I  0.359
1990 Shashidhar MS, Keana JF, Volwerk JJ, Griffith OH. Synthesis of phosphonate derivatives of myo-inositol for use in biochemical studies of inositol-binding proteins. Chemistry and Physics of Lipids. 53: 103-13. PMID 2354541 DOI: 10.1016/0009-3084(90)90138-H  0.344
1990 Shashidhar MS, Volwerk JJ, Keana JF, Griffith OH. Inhibition of phosphatidylinositol-specific phospholipase C by phosphonate substrate analogues. Biochimica Et Biophysica Acta. 1042: 410-2. PMID 2106349 DOI: 10.1016/0005-2760(90)90172-T  0.382
1990 Shashidhar MS, Keana JF, Volwerk JJ, Griffith OH. Preparation and application of an affinity matrix for phosphatidylinositol-specific phospholipase C. Chemistry and Physics of Lipids. 56: 159-67. PMID 1965711 DOI: 10.1016/0009-3084(90)90098-C  0.37
1989 Kavanaugh MP, Parker J, Bobker DH, Keana JF, Weber E. Solubilization and characterization of sigma-receptors from guinea pig brain membranes. Journal of Neurochemistry. 53: 1575-80. PMID 2552016 DOI: 10.1111/J.1471-4159.1989.Tb08554.X  0.358
1988 Kavanaugh MP, Tester BC, Scherz MW, Keana JF, Weber E. Identification of the binding subunit of the sigma-type opiate receptor by photoaffinity labeling with 1-(4-azido-2-methyl[6-3H]phenyl)-3-(2-methyl[4,6-3H]phenyl)guanidine. Proceedings of the National Academy of Sciences of the United States of America. 85: 2844-8. PMID 2833756 DOI: 10.1073/Pnas.85.8.2844  0.372
1986 Griffith OH, McMillen DA, Keana JF, Jost PC. Lipid-protein interactions in cytochrome c oxidase. A comparison of covalently attached phospholipid photo-spin-label with label free to diffuse in the bilayer. Biochemistry. 25: 574-84. PMID 3006763 DOI: 10.1021/Bi00351A010  0.311
1986 McMillen DA, Volwerk JJ, Ohishi J, Erion M, Keana JF, Jost PC, Griffith OH. Identifying regions of membrane proteins in contact with phospholipid head groups: covalent attachment of a new class of aldehyde lipid labels to cytochrome c oxidase. Biochemistry. 25: 182-93. PMID 3006751 DOI: 10.1021/Bi00349A027  0.326
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