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John E. Moses, D.Phil - Publications

Affiliations: 
2004-2005 Scripps Research Institute, La Jolla, La Jolla, CA, United States 
 2005-2007 Pharmacy University of London, London, England, United Kingdom 
 2007- Chemistry University of Nottingham, Nottingham, England, United Kingdom 
Area:
Chemical biology; Medicinal chemistry
Website:
http://www.nottingham.ac.uk/chemistry/people/john.moses
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Year Citation  Score
2023 Smedley CJ, Giel MC, Fallon T, Moses JE. Ethene-1,1-disulfonyl Difluoride (EDSF) for SuFEx Click Chemistry: Synthesis of SuFExable 1,1-Bissulfonylfluoride Substituted Cyclobutene Hubs. Angewandte Chemie (International Ed. in English). e202303916. PMID 37224463 DOI: 10.1002/anie.202303916  0.42
2022 Cheng Y, Li G, Smedley CJ, Giel MC, Kitamura S, Woehl JL, Bianco G, Forli S, Homer JA, Cappiello JR, Wolan DW, Moses JE, Sharpless KB. Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 119: e2208540119. PMID 36070343 DOI: 10.1073/pnas.2208540119  0.332
2022 Smedley CJ, Homer JA, Gialelis TL, Barrow AS, Koelln RA, Moses JE. Accelerated SuFEx Click Chemistry For Modular Synthesis. Angewandte Chemie (International Ed. in English). 61: e202112375. PMID 34755436 DOI: 10.1002/anie.202112375  0.324
2021 Giel MC, Barrow AS, Smedley CJ, Lewis W, Moses JE. Aminium cation-radical catalysed selective hydration of ()-aryl enynes. Chemical Communications (Cambridge, England). PMID 34159967 DOI: 10.1039/d1cc02257a  0.324
2020 Smedley CJ, Li G, Barrow AS, Gialelis TL, Giel MC, Ottonello A, Cheng Y, Kitamura S, Wolan DW, Sharpless KB, Moses JE. Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores From 2-Substituted-Alkynyl-1-Sulfonyl Fluoride (SASF) Hubs. Angewandte Chemie (International Ed. in English). PMID 32301265 DOI: 10.1002/Anie.202003219  0.458
2019 Giel MC, Smedley CJ, Mackie ERR, Guo T, Dong J, Soares da Costa TP, Moses JE. Metal-Free Synthesis of Functional 1-Substituted-1,2,3-Triazoles from Ethenesulfonyl Fluoride and Organic Azides. Angewandte Chemie (International Ed. in English). PMID 31709653 DOI: 10.1002/Anie.201912728  0.484
2019 Zheng Q, Woehl JL, Kitamura S, Santos-Martins D, Smedley CJ, Li G, Forli S, Moses JE, Wolan DW, Sharpless KB. SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase. Proceedings of the National Academy of Sciences of the United States of America. PMID 31484779 DOI: 10.1073/Pnas.1909972116  0.305
2019 Barrow AS, Smedley CJ, Zheng Q, Li S, Dong J, Moses JE. The growing applications of SuFEx click chemistry. Chemical Society Reviews. PMID 31364998 DOI: 10.1039/C8Cs00960K  0.329
2019 Liu F, Wang H, Li S, Bare GAL, Chen X, Wang C, Moses JE, Wu P, Sharpless KB. Biocompatible SuFEx Click Chemistry: Thionyl Tetrafluoride (SOF4) Derived Connective Hubs For Bioconjugation to DNA and Proteins. Angewandte Chemie (International Ed. in English). PMID 30998840 DOI: 10.1002/Anie.201902489  0.389
2019 Smedley CJ, Zheng Q, Gao B, Li S, Molino A, Duivenvoorden HM, Parker BS, Wilson DJD, Sharpless KB, Moses JE. Bifluoride Ion Mediated SuFEx Trifluoromethylation of Sulfonyl Fluorides and Iminosulfur Oxydifluorides. Angewandte Chemie (International Ed. in English). PMID 30740848 DOI: 10.1002/Anie.201813761  0.419
2018 Smedley CJ, Stanley PA, Qazzaz ME, Prota AE, Olieric N, Collins H, Eastman H, Barrow AS, Lim KH, Kam TS, Smith BJ, Duivenvoorden HM, Parker BS, Bradshaw TD, Steinmetz MO, ... Moses JE, et al. Sustainable Syntheses of (-)-Jerantinines A & E and Structural Characterisation of the Jerantinine-Tubulin Complex at the Colchicine Binding Site. Scientific Reports. 8: 10617. PMID 30006510 DOI: 10.1038/S41598-018-28880-2  0.31
2018 Sharma P, Bhat SV, Prabhath MRR, Molino A, Nauha E, Wilson DJD, Moses JE. Synthesis of 1,2,4-Triazol-3-imines via Selective Stepwise Cycloaddition of Nitrile Imines with Organo-cyanamides. Organic Letters. PMID 29952574 DOI: 10.1021/Acs.Orglett.8B01673  0.77
2018 Gahtory D, Sen R, Pujari S, Li S, Zheng Q, Moses JE, Sharpless KB, Zuilhof H. Quantitative and Orthogonal Formation and Reactivity of SuFEx Platforms. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29949211 DOI: 10.1002/Chem.201802356  0.358
2018 Smedley CJ, Giel MC, Molino A, Barrow AS, Wilson DJD, Moses JE. 1-Bromoethene-1-sulfonyl fluoride (BESF) is another good connective hub for SuFEx click chemistry. Chemical Communications (Cambridge, England). PMID 29796551 DOI: 10.1039/C8Cc03400A  0.452
2018 Sharpless KB, Gao B, Li S, Wu P, Moses JE. SuFEx Chemistry of Thionyl Tetrafluoride (SOF4) with Organolithium Nucleophiles: Synthesis of Sulfonimidoyl Fluorides, Sulfoximines, Sulfonimidamides and Sulfonimidates. Angewandte Chemie (International Ed. in English). PMID 29314580 DOI: 10.1002/Anie.201712145  0.352
2018 Powell KJ, Richens JL, Bramble JP, Han L, Sharma P, O'Shea P, Moses JE. Photochemical activity of membrane-localised polyketide derived marine natural products Tetrahedron. 74: 1191-1198. DOI: 10.1016/J.Tet.2017.10.056  0.622
2017 Moses JE, Sharma P, Barrow A, Spiteri C, Smedley C, Giel MC. SuFEx Mediated Synthesis of Sterically Hindered and Electron-Deficient Secondary and Tertiary Amides via Acyl Fluoride Intermediates. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 28612408 DOI: 10.1002/Chem.201701552  0.681
2016 Han LC, Stanley PA, Wood PJ, Sharma P, Kuruppu AI, Bradshaw TD, Moses JE. Horner-Wadsworth-Emmons approach to piperlongumine analogues with potent anti-cancer activity. Organic & Biomolecular Chemistry. PMID 27443386 DOI: 10.1039/C6Ob01160H  0.62
2016 Zhang E, Tang J, Li S, Wu P, Moses JE, Sharpless KB. Chemoselective Synthesis of Polysubstituted Pyridines from Heteroaryl Fluorosulfates. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 26990693 DOI: 10.1002/Chem.201600167  0.399
2016 Bhat SV, Robinson D, Moses JE, Sharma P. Synthesis of Oxadiazol-5-imines via the Cyclizative Capture of in Situ Generated Cyanamide Ions and Nitrile Oxides. Organic Letters. PMID 26889784 DOI: 10.1021/Acs.Orglett.6B00203  0.757
2016 Stanley PA, Spiteri C, Moore JC, Barrow AS, Sharma P, Moses JE. Biomimetic Approaches Towards The Synthesis of Complex Dimeric Natural Products. Current Pharmaceutical Design. PMID 26721256 DOI: 10.2174/1381612822666160101123106  0.675
2016 Barrow AS, Moses JE. Synthesis of Sulfonyl Azides via Lewis Base Activation of Sulfonyl Fluorides and Trimethylsilyl Azide Synlett. DOI: 10.1055/S-0035-1561626  0.407
2016 Barrow AS, Moses JE. ChemInform Abstract: Synthesis of Sulfonyl Azides via Lewis Base Activation of Sulfonyl Fluorides and Trimethylsilyl Azide. Cheminform. 47. DOI: 10.1002/chin.201649089  0.311
2015 Roe S, Gunaratnam M, Spiteri C, Sharma P, Alharthy RD, Neidle S, Moses JE. Synthesis and biological evaluation of hybrid acridine-HSP90 ligand conjugates as telomerase inhibitors. Organic & Biomolecular Chemistry. PMID 26156660 DOI: 10.1039/C5Ob01177A  0.63
2014 Cousins AR, Ritson D, Sharma P, Stevens MF, Moses JE, Searle MS. Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences. Chemical Communications (Cambridge, England). 50: 15202-5. PMID 25338751 DOI: 10.1039/C4Cc07487D  0.57
2014 Moore JC, Davies ES, Walsh DA, Sharma P, Moses JE. Formal synthesis of kingianin A based upon a novel electrochemically-induced radical cation Diels-Alder reaction. Chemical Communications (Cambridge, England). 50: 12523-5. PMID 25196219 DOI: 10.1039/C4Cc05906A  0.716
2014 Powell KJ, Han LC, Sharma P, Moses JE. Chemoselective palladium-catalyzed cyanation of alkenyl halides. Organic Letters. 16: 2158-61. PMID 24673520 DOI: 10.1021/Ol500618W  0.676
2013 Carbone G, Burnley J, Moses JE. A catalytic and tert-butoxide ion-mediated amidation of aldehydes with para-nitro azides. Chemical Communications (Cambridge, England). 49: 2759-61. PMID 23443044 DOI: 10.1039/C3Cc40452H  0.385
2013 Burnley J, Carbone G, Moses JE. Catalytic reduction of ortho - And para -azidonitrobenzenes via tert -butoxide ion mediated electron transfer Synlett. 24: 652-656. DOI: 10.1055/S-0032-1318216  0.419
2013 Borreguero AM, Sharma P, Spiteri C, Velencoso MM, Carmona MS, Moses JE, Rodríguez JF. A novel click-chemistry approach to flame retardant polyurethanes Reactive and Functional Polymers. 73: 1207-1212. DOI: 10.1016/J.Reactfunctpolym.2013.06.003  0.641
2012 Powell KJ, Sharma P, Richens JL, Davis BM, Moses JE, O'Shea P. Interactions of marine-derived γ-pyrone natural products with phospholipid membranes. Physical Chemistry Chemical Physics : Pccp. 14: 14489-91. PMID 23032190 DOI: 10.1039/C2Cp42920A  0.59
2012 Spiteri C, Moses JE. Continuous flow synthesis of secondary amides by tandem azidation-amidation of anilines Synlett. 23: 1546-1548. DOI: 10.1055/S-0031-1291013  0.379
2012 Ritson DJ, Moses JE. A fragment based click chemistry approach towards hybrid G-quadruplex ligands: Design, synthesis and biophysical evaluation Tetrahedron. 68: 197-203. DOI: 10.1016/J.Tet.2011.10.066  0.322
2011 Sharma P, Ritson DJ, Burnley J, Moses JE. A synthetic approach to kingianin A based on biosynthetic speculation. Chemical Communications (Cambridge, England). 47: 10605-7. PMID 21863194 DOI: 10.1039/C1Cc13949E  0.691
2011 Ritson DJ, Spiteri C, Moses JE. A silver-mediated one-step synthesis of oxazoles. The Journal of Organic Chemistry. 76: 3519-22. PMID 21438573 DOI: 10.1021/Jo1025332  0.403
2011 Moorhouse AD, Spiteri C, Sharma P, Zloh M, Moses JE. Targeting glycolysis: a fragment based approach towards bifunctional inhibitors of hLDH-5. Chemical Communications (Cambridge, England). 47: 230-2. PMID 20676418 DOI: 10.1039/C0Cc01166E  0.571
2011 Sharma P, Moorhouse AD, Moses JE. Microwave-enhanced reaction of thioacids with azides in aqueous medium Synlett. 2384-2386. DOI: 10.1055/S-0030-1261236  0.681
2011 Ritson DJ, Spiteri C, Moses JE. Silver-Mediated Synthesis of Oxazoles Synfacts. 2011: 710-710. DOI: 10.1055/S-0030-1260510  0.445
2011 Sharma P, Powell KJ, Burnley J, Awaad AS, Moses JE. Total synthesis of polypropionate-derived γ-pyrone natural products Synthesis. 2865-2892. DOI: 10.1055/S-0030-1260168  0.68
2011 Spiteri C, Ritson DJ, Awaad A, Moses JE. Silver mediated one-step synthesis of oxazoles from α-haloketones Journal of Saudi Chemical Society. 15: 375-378. DOI: 10.1016/J.Jscs.2011.06.021  0.458
2011 Burnley J, Ralph M, Sharma P, Moses JE. Biomimetic Electrocyclization Reactions toward Polyketide-Derived Natural Products Biomimetic Organic Synthesis. 2: 591-635. DOI: 10.1002/9783527634606.ch16  0.64
2010 Spiteri C, Keeling S, Moses JE. New synthesis of 1-substituted-1H-indazoles via 1,3-dipolar cycloaddition of in situ generated nitrile imines and benzyne. Organic Letters. 12: 3368-71. PMID 20608661 DOI: 10.1021/Ol101150T  0.457
2010 Moses JE, Ritson DJ, Zhang F, Lombardo CM, Haider S, Oldham N, Neidle S. A click chemistry approach to C3 symmetric, G-quadruplex stabilising ligands. Organic & Biomolecular Chemistry. 8: 2926-30. PMID 20498912 DOI: 10.1039/C005055E  0.34
2010 Sharma P, Moses JE. Ethynyldiisopropylsilyl: a new alkynylsilane protecting group and "click" linker. Organic Letters. 12: 2860-3. PMID 20486654 DOI: 10.1021/Ol100968T  0.644
2010 Roe S, Ritson DJ, Garner T, Searle M, Moses JE. Tuneable DNA-based asymmetric catalysis using a G-quadruplex supramolecular assembly. Chemical Communications (Cambridge, England). 46: 4309-11. PMID 20458390 DOI: 10.1039/C0Cc00194E  0.347
2010 Spiteri C, Sharma P, Zhang F, Macdonald SJ, Keeling S, Moses JE. An improved synthesis of 1,2-benzisoxazoles: TBAF mediated 1,3-dipolar cycloaddition of nitrile oxides and benzyne. Chemical Communications (Cambridge, England). 46: 1272-4. PMID 20449274 DOI: 10.1039/B922489K  0.693
2010 Spiteri C, Mason C, Zhang F, Ritson DJ, Sharma P, Keeling S, Moses JE. An efficient entry to 1,2-benzisoxazoles via 1,3-dipolar cycloaddition of in situ generated nitrile oxides and benzyne. Organic & Biomolecular Chemistry. 8: 2537-42. PMID 20372741 DOI: 10.1039/B927235F  0.643
2010 Spiteri C, Moses JE. Copper-catalyzed azide-alkyne cycloaddition: regioselective synthesis of 1,4,5-trisubstituted 1,2,3-triazoles. Angewandte Chemie (International Ed. in English). 49: 31-3. PMID 19921729 DOI: 10.1002/Anie.200905322  0.453
2010 Spiteri C, Mason C, Zhang F, Ritson DJ, Sharma P, Keeling S, Moses JE. Synthesis of 1,2-Benzisoxazoles via a 1,3-DipolarCycloaddition Synfacts. 2010: 519-519. DOI: 10.1055/S-0029-1219728  0.688
2010 Sharma P, Moses JE. Photochemical studies of the tridachiahydropyrones in seawater Synlett. 525-528. DOI: 10.1055/S-0029-1218544  0.577
2009 Sharma P, Lygo B, Lewis W, Moses JE. Biomimetic synthesis and structural reassignment of the tridachiahydropyrones. Journal of the American Chemical Society. 131: 5966-72. PMID 19341238 DOI: 10.1021/Ja900369Z  0.661
2009 Zhang F, Moses JE. Benzyne click chemistry with in situ generated aromatic azides. Organic Letters. 11: 1587-90. PMID 19267454 DOI: 10.1021/Ol9002338  0.487
2009 Spiteri C, Moses J. Kupferkatalysierte Azid-Alkin-Cycloadditionen: regioselektive Synthese von 1,4,5-trisubstituierten 1,2,3-Triazolen Angewandte Chemie. 122: 33-36. DOI: 10.1002/Ange.200905322  0.39
2008 Sharma P, Griffiths N, Moses JE. Biomimetic synthesis and structural revision of (+/-)-tridachiahydropyrone. Organic Letters. 10: 4025-7. PMID 18717585 DOI: 10.1021/Ol8015836  0.661
2008 Eade SJ, Walter MW, Byrne C, Odell B, Rodriguez R, Baldwin JE, Adlington RM, Moses JE. Biomimetic synthesis of pyrone-derived natural products: exploring chemical pathways from a unique polyketide precursor. The Journal of Organic Chemistry. 73: 4830-9. PMID 18517253 DOI: 10.1021/Jo800220W  0.668
2008 Moorhouse AD, Moses JE. Microwave enhancement of a 'one-pot' tandem azidation-'click' cycloaddition of anilines Synlett. 2089-2092. DOI: 10.1055/S-2008-1078019  0.356
2007 Moses JE, Moorhouse AD. The growing applications of click chemistry. Chemical Society Reviews. 36: 1249-62. PMID 17619685 DOI: 10.1039/B613014N  0.35
2007 Barral K, Moorhouse AD, Moses JE. Efficient conversion of aromatic amines into azides: a one-pot synthesis of triazole linkages. Organic Letters. 9: 1809-11. PMID 17391043 DOI: 10.1021/Ol070527H  0.502
2007 Rodriguez R, Adlington RM, Eade SJ, Walter MW, Baldwin JE, Moses JE. Total synthesis of cyercene A and the biomimetic synthesis of (±)-9,10-deoxytridachione and (±)-ocellapyrone A Tetrahedron. 63: 4500-4509. DOI: 10.1016/J.Tet.2007.03.057  0.666
2007 Rodriguez R, Adlington RM, Eade SJ, Walter MW, Baldwin JE, Moses JE. Total Synthesis of Cyercene A (I) and the Biomimetic Synthesis of (.+-.)-9,10-Deoxytridachione (II) and (.+-.)-Ocellapyrone A. Cheminform. 38. DOI: 10.1002/chin.200735216  0.458
2006 Comméiras L, Moses JE, Adlington RM, Baldwin JE, Cowley AR, Baker CM, Albrecht B, Grant GH. Total synthesis of the epoxyquinol dimer (+)-panepophenanthrin: application of a diastereospecific biomimetic Diels-Alder dimerisation Tetrahedron. 62: 9892-9901. DOI: 10.1016/J.Tet.2006.08.010  0.698
2006 Jacobsen MF, Moses JE, Adlington RM, Baldwin JE. The biomimetic synthesis of SNF4435C and SNF4435D, and the total synthesis of the polyene metabolites aureothin, N-acetyl-aureothamine and spectinabilin Tetrahedron. 62: 1675-1689. DOI: 10.1016/J.Tet.2005.11.058  0.62
2006 Jacobsen MF, Moses JE, Adlington RM, Baldwin JE. The Biomimetic Synthesis of SNF4435C (I) and SNF4435D (II), and the Total Synthesis of the Polyene Metabolites Aureothin (IIIa), N-Acetyl-aureothamine (IIIb) and Spectinabilin (IV). Cheminform. 37. DOI: 10.1002/chin.200625206  0.429
2005 Moses JE, Adlington RM. Sir Jack Baldwin, FRS: biomimetic studies at Oxford. Chemical Communications (Cambridge, England). 5945-52. PMID 16333494 DOI: 10.1039/B512961C  0.541
2005 Rodriguez R, Moses JE, Adlington RM, Baldwin JE. A new and efficient method for o-quinone methide intermediate generation: application to the biomimetic synthesis of the benzopyran derived natural products (+/-)-lucidene and (+/-)-alboatrin. Organic & Biomolecular Chemistry. 3: 3488-95. PMID 16172685 DOI: 10.1039/B508972G  0.664
2005 Jacobsen MF, Moses JE, Adlington RM, Baldwin JE. The total synthesis of spectinabilin and its biomimetic conversion to SNF4435C and SNF4435D. Organic Letters. 7: 2473-6. PMID 15932226 DOI: 10.1021/Ol0507874  0.685
2005 Moses JE, Adlington RM, Rodriguez R, Eade SJ, Baldwin JE. Biomimetic synthesis of (+/-)-9,10-deoxytridachione. Chemical Communications (Cambridge, England). 1687-9. PMID 15791299 DOI: 10.1039/B418988D  0.677
2005 Jacobsen MF, Moses JE, Adlington RM, Baldwin JE. A short total synthesis of aureothin and N-acetylaureothamine. Organic Letters. 7: 641-4. PMID 15704914 DOI: 10.1021/Ol047594L  0.692
2005 Jacobsen MF, Moses JE, Adlington RM, Baldwin JE. Total Synthesis of Aureothin and N-Acetylaureothamine Synfacts. 2005: 9-9. DOI: 10.1055/S-2005-865349  0.352
2005 Jacobsen MF, Moses JE, Adlington RM, Baldwin JE. The Total Synthesis of Spectinabilin (I) and Its Biomimetic Conversion to SNF4435C (II) and SNF4435D (III). Cheminform. 36. DOI: 10.1002/chin.200544226  0.56
2005 Jacobsen MF, Moses JE, Adlington RM, Baldwin JE. A Short Total Synthesis of Aureothin (Ia) and N-Acetylaureothamine (Ib). Cheminform. 36. DOI: 10.1002/chin.200528208  0.389
2004 Rodriguez R, Adlington RM, Moses JE, Cowley A, Baldwin JE. A new and efficient method for o-quinone methide intermediate generation: application to the biomimetic synthesis of (+/-)-Alboatrin. Organic Letters. 6: 3617-9. PMID 15387562 DOI: 10.1021/Ol048479D  0.627
2004 Moses JE, Baldwin JE, Adlington RM. An efficient synthesis of cyercene A Tetrahedron Letters. 45: 6447-6448. DOI: 10.1016/J.Tetlet.2004.06.125  0.676
2003 Moses JE, Baldwin JE, Brückner S, Eade SJ, Adlington RM. Biomimetic studies on polyenes. Organic & Biomolecular Chemistry. 1: 3670-84. PMID 14649898 DOI: 10.1039/B306933H  0.653
2003 Moses JE, Commeiras L, Baldwin JE, Adlington RM. Total synthesis of panepophenanthrin. Organic Letters. 5: 2987-8. PMID 12916962 DOI: 10.1021/Ol0349817  0.688
2003 Moses JE, Baldwin JE, Marquez R, Adlington RM, Claridge TD, Odell B. Biomimetic synthesis of the crispatene core. Organic Letters. 5: 661-3. PMID 12605484 DOI: 10.1021/Ol020242Z  0.661
2003 Moses JE, Baldwin JE, Adlington RM, Cowley AR, Marquez R. Thermally induced cascade pericyclic reaction pathways from tetraene esters Tetrahedron Letters. 44: 6625-6627. DOI: 10.1016/S0040-4039(03)01673-3  0.614
2003 Brückner S, Baldwin JE, Moses J, Adlington RM, Cowley AR. Mechanistic evidence supporting the biosynthesis of photodeoxytridachione Tetrahedron Letters. 44: 7471-7473. DOI: 10.1016/J.Tetlet.2003.08.021  0.666
2002 Moses JE, Baldwin JE, Marquez R, Adlington RM, Cowley AR. Studies on the biomimetic synthesis of SNF4435 C and D. Organic Letters. 4: 3731-4. PMID 12375930 DOI: 10.1021/Ol020157R  0.688
2000 Thorn MG, Moses JE, Fanwick PE, Rothwell LP. New tantalum compounds supported by 3,3′-disubstituted-l,l′-bi-2naphthoxide ligation Journal of the Chemical Society, Dalton Transactions. 2659-2660. DOI: 10.1039/B005681M  0.317
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