Ramon Vilar - Publications

Affiliations: 
Imperial College London, London, England, United Kingdom 

73 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Vilar R, Kench T, Summers PA, Kuimova MK, Lewis JEM. Rotaxanes as cages to control DNA binding, cytotoxicity and cellular uptake of a small molecule. Angewandte Chemie (International Ed. in English). PMID 33577711 DOI: 10.1002/anie.202100151  0.52
2021 Summers PA, Lewis BW, Gonzalez-Garcia J, Porreca RM, Lim AHM, Cadinu P, Martin-Pintado N, Mann DJ, Edel JB, Vannier JB, Kuimova MK, Vilar R. Visualising G-quadruplex DNA dynamics in live cells by fluorescence lifetime imaging microscopy. Nature Communications. 12: 162. PMID 33420085 DOI: 10.1038/s41467-020-20414-7  0.6
2020 Reeh K, Summers PA, Gould IR, Woscholski R, Vilar R. Design, synthesis and evaluation of a tripodal receptor for phosphatidylinositol phosphates. Scientific Reports. 10: 18450. PMID 33116198 DOI: 10.1038/s41598-020-75484-w  1
2020 Vilar R, Lewis BW, Bisballe N, Santella M, Summers PA, Vannier JB, Kuimova MK, Laursen BW. Assessing the key photophysical properties of triangulenium dyes for DNA binding by alteration of the fluorescent core. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 33105523 DOI: 10.1002/chem.202003875  0.52
2020 Maurice J, Lett AM, Skinner C, Lim A, Richardson M, Thomas AP, Summers PA, Vyas K, Tadbier AW, Vilar R, Kuimova MK, Miodragovic S, Vergis N, Kelly P, Cordeiro MF, et al. Transcutaneous fluorescence spectroscopy as a tool for non-invasive monitoring of gut function: first clinical experiences. Scientific Reports. 10: 16169. PMID 32999336 DOI: 10.1038/s41598-020-73149-2  0.52
2020 Torres-Huerta A, Chan TG, White AJP, Vilar R. Molecular recognition of bisphosphonate-based drugs by di-zinc receptors in aqueous solution and on gold nanoparticles. Dalton Transactions (Cambridge, England : 2003). PMID 32314772 DOI: 10.1039/d0dt00930j  0.6
2019 Vilar R, Ruehl CL, Lim AHM, Kench T, Mann DJ. An octahedral cobalt(III) complex with axial NH3 ligands that templates and selectively stabilises G-quadruplex DNA. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 31087710 DOI: 10.1002/chem.201901569  0.6
2018 Ferraro G, Pica A, Petruk G, Pane F, Amoresano A, Cilibrizzi A, Vilar R, Monti DM, Merlino A. Preparation, structure, cytotoxicity and mechanism of action of ferritin-Pt(II) terpyridine compound nanocomposites. Nanomedicine (London, England). PMID 30501559 DOI: 10.2217/nnm-2018-0259  0.44
2018 Ferraro G, Marzo T, Infrasca T, Cilibrizzi A, Vilar R, Messori L, Merlino A. A case of extensive protein platination: the reaction of lysozyme with a Pt(ii)-terpyridine complex. Dalton Transactions (Cambridge, England : 2003). PMID 29904761 DOI: 10.1039/c8dt01254g  0.44
2017 Cilibrizzi A, Fedorova M, Collins J, Leatherbarrow R, Woscholski R, Vilar R. A tri-functional vanadium(iv) complex to detect cysteine oxidation. Dalton Transactions (Cambridge, England : 2003). PMID 28513686 DOI: 10.1039/c7dt00076f  1
2016 Wilson N, Mak LH, Cilibrizzi A, Gee AD, Long NJ, Woscholski R, Vilar R. A lipophilic copper(ii) complex as an optical probe for intracellular detection of NO. Dalton Transactions (Cambridge, England : 2003). PMID 27792231 DOI: 10.1039/c6dt02880b  1
2016 Klejevskaja B, Pyne AL, Reynolds M, Shivalingam A, Thorogate R, Hoogenboom BW, Ying L, Vilar R. Studies of G-quadruplexes formed within self-assembled DNA mini-circles. Chemical Communications (Cambridge, England). PMID 27722269 DOI: 10.1039/c6cc07110d  0.6
2016 Kotar A, Wang B, Shivalingam A, Gonzalez-Garcia J, Vilar R, Plavec J. NMR Structure of a Triangulenium-Based Long-Lived Fluorescence Probe Bound to a G-Quadruplex. Angewandte Chemie (International Ed. in English). PMID 27577037 DOI: 10.1002/anie.201606877  0.6
2016 Collins J, Cilibrizzi A, Fedorova M, Whyte G, Mak LH, Guterman I, Leatherbarrow R, Woscholski R, Vilar R. Vanadyl complexes with dansyl-labelled di-picolinic acid ligands: synthesis, phosphatase inhibition activity and cellular uptake studies. Dalton Transactions (Cambridge, England : 2003). 45: 7104-13. PMID 27008377 DOI: 10.1039/c5dt04753f  0.6
2016 Shivalingam A, Vyšniauskas A, Albrecht T, White AJ, Kuimova MK, Vilar R. Trianguleniums as Optical Probes for G-Quadruplexes: A Photophysical, Electrochemical and Computational Study. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 26880483 DOI: 10.1002/chem.201504099  0.6
2016 Ang DL, Harper BW, Cubo L, Mendoza O, Vilar R, Aldrich-Wright J. Quadruplex DNA-Stabilising Dinuclear Platinum(II) Terpyridine Complexes with Flexible Linkers. Chemistry (Weinheim An Der Bergstrasse, Germany). 22: 2317-25. PMID 26670391 DOI: 10.1002/chem.201503663  0.32
2015 Shivalingam A, Izquierdo MA, Marois AL, Vyšniauskas A, Suhling K, Kuimova MK, Vilar R. The interactions between a small molecule and G-quadruplexes are visualized by fluorescence lifetime imaging microscopy. Nature Communications. 6: 8178. PMID 26350962 DOI: 10.1038/ncomms9178  0.6
2015 Mion G, Gianferrara T, Bergamo A, Gasser G, Pierroz V, Rubbiani R, Vilar R, Leczkowska A, Alessio E. Phototoxic Activity and DNA Interactions of Water-Soluble Porphyrins and Their Rhenium(I) Conjugates. Chemmedchem. 10: 1901-14. PMID 26332425 DOI: 10.1002/cmdc.201500288  0.6
2015 Stafford VS, Suntharalingam K, Shivalingam A, White AJ, Mann DJ, Vilar R. Syntheses of polypyridyl metal complexes and studies of their interaction with quadruplex DNA. Dalton Transactions (Cambridge, England : 2003). 44: 3686-700. PMID 25361228 DOI: 10.1039/c4dt02910k  0.6
2014 Moffat CD, Weiss DJ, Shivalingam A, White AJ, Salaün P, Vilar R. Molecular recognition and scavenging of arsenate from aqueous solution using dimetallic receptors. Chemistry (Weinheim An Der Bergstrasse, Germany). 20: 17168-77. PMID 25338508 DOI: 10.1002/chem.201404723  0.6
2014 Sala R, Nguyen QD, Patel CB, Mann D, Steinke JH, Vilar R, Aboagye EO. Phosphorylation status of thymidine kinase 1 following antiproliferative drug treatment mediates 3'-deoxy-3'-[18F]-fluorothymidine cellular retention. Plos One. 9: e101366. PMID 25003822 DOI: 10.1371/journal.pone.0101366  0.6
2014 Ghosh S, Mendoza O, Cubo L, Rosu F, Gabelica V, White AJP, Vilar R. Assembly of palladium(II) and platinum(II) metallo-rectangles with a guanosine-substituted terpyridine and study of their interactions with quadruplex DNA Chemistry (Weinheim An Der Bergstrasse, Germany). 20: 4772-4779. PMID 24596127 DOI: 10.1002/chem.201304905  0.6
2014 Abd Karim NH, Mendoza O, Shivalingam A, Thompson AJ, Ghosh S, Kuimova MK, Vilar R. Salphen metal complexes as tunable G-quadruplex binders and optical probes Rsc Advances. 4: 3355-3363. DOI: 10.1039/c3ra44793f  0.6
2014 D'Arcy M, Bullough F, Moffat C, Borgomeo E, Teh M, Vilar R, Weiss DJ. Adsorption of oxy-anions in the teaching laboratory: An experiment to study a fundamental environmental engineering problem Journal of Chemical Education. 91: 505-510. DOI: 10.1021/ed300220d  0.6
2013 Whyte GF, Vilar R, Woscholski R. Molecular recognition with boronic acids-applications in chemical biology. Journal of Chemical Biology. 6: 161-74. PMID 24432132 DOI: 10.1007/s12154-013-0099-0  1
2013 Ghosh S, Silber GT, White AJ, Robertson N, Vilar R. Synthesis of a self-assembled copper(II) metallo-rectangle with a guanosine-substituted terpyridine. Dalton Transactions (Cambridge, England : 2003). 42: 13813-6. PMID 23963378 DOI: 10.1039/c3dt51845k  0.72
2013 von Grebe P, Suntharalingam K, Vilar R, Sanz Miguel PJ, Herres-Pawlis S, Lippert B. A conformationally flexible dinuclear Pt(II) complex with differential behavior of its two states toward quadruplex DNA. Chemistry (Weinheim An Der Bergstrasse, Germany). 19: 11429-38. PMID 23852779 DOI: 10.1002/chem.201301400  0.6
2013 Suntharalingam K, Mendoza O, Duarte AA, Mann DJ, Vilar R. A platinum complex that binds non-covalently to DNA and induces cell death via a different mechanism than cisplatin. Metallomics : Integrated Biometal Science. 5: 514-23. PMID 23487034 DOI: 10.1039/c3mt20252f  0.6
2013 Zhou W, Suntharalingam K, Brand NJ, Barton PJ, Vilar R, Ying L. Possible regulatory roles of promoter g-quadruplexes in cardiac function-related genes - human TnIc as a model. Plos One. 8: e53137. PMID 23326389 DOI: 10.1371/journal.pone.0053137  0.6
2012 Suntharalingam K, ??czkowska A, Furrer MA, Wu Y, Kuimova MK, Therrien B, White AJ, Vilar R. A cyclometallated platinum complex as a selective optical switch for quadruplex DNA. Chemistry (Weinheim An Der Bergstrasse, Germany). 18: 16277-82. PMID 23165895 DOI: 10.1002/chem.201202990  0.6
2012 Suntharalingam K, Hunt DJ, Duarte AA, White AJ, Mann DJ, Vilar R. A tri-copper(II) complex displaying DNA-cleaving properties and antiproliferative activity against cancer cells. Chemistry (Weinheim An Der Bergstrasse, Germany). 18: 15133-41. PMID 23059789 DOI: 10.1002/chem.201202482  0.6
2012 Gong X, Miller PW, Gee AD, Long NJ, de Mello AJ, Vilar R. Gas-liquid segmented flow microfluidics for screening Pd-catalyzed carbonylation reactions. Chemistry (Weinheim An Der Bergstrasse, Germany). 18: 2768-72. PMID 22331821 DOI: 10.1002/chem.201104059  0.6
2012 Campbell NH, Karim NHA, Parkinson GN, Gunaratnam M, Petrucci V, Todd AK, Vilar R, Neidle S. Molecular basis of structure-activity relationships between salphen metal complexes and human telomeric DNA quadruplexes Journal of Medicinal Chemistry. 55: 209-222. PMID 22112241 DOI: 10.1021/jm201140v  0.6
2012 Martí-Centelles V, Burguete MI, Galindo F, Izquierdo MA, Kumar DK, White AJ, Luis SV, Vilar R. Fluorescent acridine-based receptors for H2PO4(-). The Journal of Organic Chemistry. 77: 490-500. PMID 22077800 DOI: 10.1021/jo202077v  0.72
2012 Tate CW, deMello A, Gee AD, Kealey S, Vilar R, White AJ, Long NJ. Hemilabile and reversible carbon monoxide binding properties of iron(II), cobalt(II) and nickel(II) complexes containing a new tridentate P-S-N ligand. Dalton Transactions (Cambridge, England : 2003). 41: 83-9. PMID 22011880 DOI: 10.1039/c1dt11248a  0.6
2011 Child ES, Georgiades SN, Rose KN, Stafford VS, Patel CB, Steinke JH, Mann DJ, Vilar R. Inhibition of mitogen-activated protein kinase (MAPK) and cyclin-dependent kinase 2 (Cdk2) by platinum(II) phenanthroline complexes. Journal of Chemical Biology. 4: 159-65. PMID 22368708 DOI: 10.1007/s12154-011-0059-5  0.6
2011 Mak LH, Georgiades SN, Rosivatz E, Whyte GF, Mirabelli M, Vilar R, Woscholski R. A small molecule mimicking a phosphatidylinositol (4,5)-bisphosphate binding pleckstrin homology domain. Acs Chemical Biology. 6: 1382-90. PMID 21958214 DOI: 10.1021/cb2003187  1
2011 D'Arcy M, Weiss D, Bluck M, Vilar R. Adsorption kinetics, capacity and mechanism of arsenate and phosphate on a bifunctional TiO 2-Fe 2O 3 bi-composite Journal of Colloid and Interface Science. 364: 205-212. PMID 21907345 DOI: 10.1016/j.jcis.2011.08.023  0.6
2011 Surman AJ, Kenny GD, Kumar DK, Bell JD, Casey DR, Vilar R. Targeting of anionic membrane species by lanthanide(III) complexes: towards improved MRI contrast agents for apoptosis. Chemical Communications (Cambridge, England). 47: 10245-7. PMID 21847480 DOI: 10.1039/c1cc13284a  0.6
2011 Buscemi G, Miller PW, Kealey S, Gee AD, Long NJ, Passchier J, Vilar R. Rapid carbonylative coupling reactions using palladium(I) dimers: applications to 11CO-radiolabelling for the synthesis of PET tracers. Organic & Biomolecular Chemistry. 9: 3499-503. PMID 21431235 DOI: 10.1039/c1ob05268c  0.44
2011 Surman AJ, Bonnet CS, Lowe MP, Kenny GD, Bell JD, Tóth E, Vilar R. A pyrophosphate-responsive gadolinium(III) MRI contrast agent. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 223-30. PMID 21207619 DOI: 10.1002/chem.201001397  0.6
2011 Miller PW, Audrain H, Bender D, deMello AJ, Gee AD, Long NJ, Vilar R. Rapid carbon-11 radiolabelling for PET using microfluidics. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 460-3. PMID 21207561 DOI: 10.1002/chem.201002644  0.44
2011 Georgiades SN, Mak LH, Angurell I, Rosivatz E, Firouz Mohd Mustapa M, Polychroni C, Woscholski R, Vilar R. Identification of a potent activator of Akt phosphorylation from a novel series of phenolic, picolinic, pyridino, and hydroxamic zinc(II) complexes. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 16: 195-208. PMID 20972690 DOI: 10.1007/s00775-010-0716-0  1
2010 Mak LH, Vilar R, Woscholski R. Characterisation of the PTEN inhibitor VO-OHpic. Journal of Chemical Biology. 3: 157-63. PMID 21643420 DOI: 10.1007/s12154-010-0041-7  1
2010 Martinelli J, Balali-Mood B, Panizzo R, Lythgoe MF, White AJ, Ferretti P, Steinke JH, Vilar R. Coordination chemistry of amide-functionalised tetraazamacrocycles: structural, relaxometric and cytotoxicity studies. Dalton Transactions (Cambridge, England : 2003). 39: 10056-67. PMID 20877892 DOI: 10.1039/c0dt00815j  0.6
2010 Suntharalingam K, White AJ, Vilar R. Two metals are better than one: investigations on the interactions between dinuclear metal complexes and quadruplex DNA. Inorganic Chemistry. 49: 8371-80. PMID 20795697 DOI: 10.1021/ic100884p  0.72
2010 Georgiades SN, Abd Karim NH, Suntharalingam K, Vilar R. Interaction of metal complexes with G-quadruplex DNA. Angewandte Chemie (International Ed. in English). 49: 4020-34. PMID 20503216 DOI: 10.1002/anie.200906363  0.76
2010 Suntharalingam K, Gupta D, Sanz Miguel PJ, Lippert B, Vilar R. Synthesis, structural characterisation and quadruplex DNA binding studies of a new gold(III) pyrazolylpyridine complex. Chemistry (Weinheim An Der Bergstrasse, Germany). 16: 3613-6. PMID 20187046 DOI: 10.1002/chem.200903501  0.6
2009 Barry NP, Abd Karim NH, Vilar R, Therrien B. Interactions of ruthenium coordination cubes with DNA. Dalton Transactions (Cambridge, England : 2003). 10717-9. PMID 20023899 DOI: 10.1039/b913642h  0.6
2009 Suntharalingam K, White AJ, Vilar R. Synthesis, structural characterization, and quadruplex DNA binding studies of platinum(II)-terpyridine complexes. Inorganic Chemistry. 48: 9427-35. PMID 19728717 DOI: 10.1021/ic901319n  0.72
2009 Reed JE, White AJP, Neidle S, Vilar R. Effect of metal coordination on the interaction of substituted phenanthroline and pyridine ligands with quadruplex DNA Dalton Transactions. 2558-2568. PMID 19319401 DOI: 10.1039/b820086f  0.6
2008 Arola-Arnal A, Benet-Buchholz J, Neidle S, Vilar R. Effects of metal coordination geometry on stabilization of human telomeric quadruplex DNA by square-planar and square-pyramidal metal complexes. Inorganic Chemistry. 47: 11910-9. PMID 19053336 DOI: 10.1021/ic8016547  0.6
2008 Miller PW, Long NJ, Vilar R, Gee AD. Synthesis of 11C, 18F, 15O, and 13N radiolabels for positron emission tomography. Angewandte Chemie (International Ed. in English). 47: 8998-9033. PMID 18988199 DOI: 10.1002/anie.200800222  0.6
2008 Reed J, Gunaratnam M, Beltran M, Reszka AP, Vilar R, Neidle S. TRAP-LIG, a modified telomere repeat amplification protocol assay to quantitate telomerase inhibition by small molecules. Analytical Biochemistry. 380: 99-105. PMID 18534183 DOI: 10.1016/j.ab.2008.05.013  0.6
2007 Diaz P, Tovilla JA, Ballester P, Benet-Buchholz J, Vilar R. Synthesis, structural characterization and anion binding studies of palladium macrocycles with hydrogen-bonding ligands. Dalton Transactions (Cambridge, England : 2003). 3516-25. PMID 17680041 DOI: 10.1039/b703660d  0.6
2007 Miller PW, Long NJ, de Mello AJ, Vilar R, Audrain H, Bender D, Passchier J, Gee A. Rapid multiphase carbonylation reactions by using a microtube reactor: applications in positron emission tomography 11C-radiolabeling. Angewandte Chemie (International Ed. in English). 46: 2875-8. PMID 17348061 DOI: 10.1002/anie.200604541  0.44
2007 Tovilla JA, Carlqvist P, Benet-Buchholz J, Maseras F, Vilar R. Di-palladium complexes with urea-containing ligands as anion receptors Supramolecular Chemistry. 19: 599-611. DOI: 10.1080/10610270701297418  0.6
2007 Reed JE, Neidle S, Vilar R. Stabilisation of human telomeric quadruplex DNA and inhibition of telomerase by a platinum-phenanthroline complex Chemical Communications. 4366-4368. DOI: 10.1039/b709898g  0.6
2006 Rosivatz E, Matthews JG, McDonald NQ, Mulet X, Ho KK, Lossi N, Schmid AC, Mirabelli M, Pomeranz KM, Erneux C, Lam EWF, Vilar R, Woscholski R. A small molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN). Acs Chemical Biology. 1: 780-790. PMID 17240976 DOI: 10.1021/cb600352f  0.6
2006 Christmann U, Pantazis DA, Benet-Buchholz J, McGrady JE, Maseras F, Vilar R. Experimental and theoretical investigations of new dinuclear palladium complexes as precatalysts for the amination of aryl chlorides. Journal of the American Chemical Society. 128: 6376-90. PMID 16683802 DOI: 10.1021/ja057825z  0.6
2006 Reed JE, Arnal AA, Neidle S, Vilar R. Stabilization of G-quadruplex DNA and inhibition of telomerase activity by square-planar nickel(II) complexes Journal of the American Chemical Society. 128: 5992-5993. PMID 16669641 DOI: 10.1021/ja058509n  0.6
2006 Díaz P, Benet-Buchholz J, Vilar R, White AJ. Anion influence on the structures of a series of copper(II) metal-organic frameworks. Inorganic Chemistry. 45: 1617-26. PMID 16471974 DOI: 10.1021/ic051457i  0.72
2006 Miller PW, Long NJ, de Mello AJ, Vilar R, Passchier J, Gee A. Rapid formation of amides via carbonylative coupling reactions using a microfluidic device. Chemical Communications (Cambridge, England). 546-8. PMID 16432578 DOI: 10.1039/b515710b  0.44
2006 Christmann U, Pantazis DA, Benet-Buchholz J, McGrady JE, Maseras F, Vilar R. Synthesis and computational studies of palladium(I) dimers Pd 2X2(PtBu2,Ph)2 (X = Br, I): Phenyl versus halide bridging modes Organometallics. 25: 5990-5995. DOI: 10.1021/om060712j  0.6
2005 Tovilla JA, Vilar R, White AJ. A di-palladium urea complex as a molecular receptor for anions. Chemical Communications (Cambridge, England). 4839-41. PMID 16193132 DOI: 10.1039/b509565d  0.72
2005 Burkill HA, Robertson N, Vilar R, White AJ, Williams DJ. Synthesis, structural characterization, and magnetic studies of polynuclear iron complexes with a new disubstituted pyridine ligand. Inorganic Chemistry. 44: 3337-46. PMID 15847444 DOI: 10.1021/ic048620e  0.72
2004 Diaz P, Mingos DM, Vilar R, White AJ, Williams DJ. Anion-templated synthesis of metallacages as a means for the colorimetric detection of chlorides. Inorganic Chemistry. 43: 7597-604. PMID 15554624 DOI: 10.1021/ic049508j  0.72
2004 Christmann U, Vilar R, White AJ, Williams DJ. Synthesis of two novel dinuclear palladium(I) complexes and studies of their catalytic activity in amination reactions. Chemical Communications (Cambridge, England). 1294-5. PMID 15154043 DOI: 10.1039/b402283a  0.72
2004 Schmid AC, Byrne RD, Vilar R, Woscholski R. Bisperoxovanadium compounds are potent PTEN inhibitors. Febs Letters. 566: 35-8. PMID 15147864 DOI: 10.1016/j.febslet.2004.03.102  1
2001 Rais D, Yau J, Mingos DM, Vilar R, White AJ, Williams DJ. Anion-Templated Syntheses of Rhombohedral Silver-Alkynyl Cage Compounds. Angewandte Chemie (International Ed. in English). 40: 3464-3467. PMID 11592172 DOI: 10.1002/1521-3773(20010917)40:18<3464::AID-ANIE3464>3.0.CO;2-M  0.72
1998 Vilar R, Mingos DMP, White AJP, Williams DJ. Anion Control in the Self-Assembly of a Cage Coordination Complex. Angewandte Chemie (International Ed. in English). 37: 1258-1261. PMID 29711234 DOI: 10.1002/(SICI)1521-3773(19980518)37:9<1258::AID-ANIE1258>3.0.CO;2-#  0.6
1995 Escudero A, Vilar R, Salcedo R, Ogawa T. Effects of substituent groups and substituted benzenes on the polymerization of phenylacetylenes initiated by di-μ-pentafluorothiophenolate bis(1,5-cyclooctadiene) rhodium(I) European Polymer Journal. 31: 1135-1138. DOI: 10.1016/0014-3057(95)00075-5  0.6
1994 Vilar R, Salcedo R, Gaviño R, Ogawa T. Polymerization of phenylacetylene with Di-μ-pentafluorothiophenolate bis (1,5-cyclooctadiene) rhodium (I) and its analogues European Polymer Journal. 30: 1237-1242. DOI: 10.1016/0014-3057(94)90133-3  0.6
Show low-probability matches.