Rajat Rohatgi - Publications

Affiliations: 
Oncology Stanford University School of Medicine, Palo Alto, CA, United States 
Area:
Biochemical Mechanisms of Hedgehog (Hh) Signaling
Website:
http://rohatgi.stanford.edu/

54 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Dubey R, van Kerkhof P, Jordens I, Malinauskas T, Pusapati GV, McKenna JK, Li D, Carette JE, Ho M, Siebold C, Maurice M, Lebensohn AM, Rohatgi R. R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling. Elife. 9. PMID 32432544 DOI: 10.7554/Elife.54469  0.88
2020 Dubey R, Kerkhof Pv, Jordens I, Malinauskas T, Pusapati GV, McKenna JK, Li D, Carette JE, Ho M, Siebold C, Maurice M, Lebensohn AM, Rohatgi R. Author response: R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling Elife. DOI: 10.7554/Elife.54469.Sa2  0.88
2019 Patel BB, Lebensohn AM, Pusapati GV, Carette JE, Salzman J, Rohatgi R. Discovery of gene regulatory elements through a new bioinformatics analysis of haploid genetic screens. Plos One. 14: e0198463. PMID 30695034 DOI: 10.1371/Journal.Pone.0198463  0.88
2019 Lebensohn AM, Rohatgi R. Abstract 3445: Mechanism, physiological and therapeutic implications of LGR-independent potentiation of WNT signaling by R-spondins Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-3445  0.88
2018 Lebensohn AM, Rohatgi R. R-spondins can potentiate WNT signaling without LGRs. Elife. 7. PMID 29405118 DOI: 10.7554/Elife.33126  0.88
2016 Lebensohn AM, Dubey R, Neitzel LR, Tacchelly-Benites O, Yang E, Marceau CD, Davis EM, Patel BB, Bahrami-Nejad Z, Travaglini KJ, Ahmed Y, Lee E, Carette JE, Rohatgi R. Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling. Elife. 5. PMID 27996937 DOI: 10.7554/Elife.21459  0.88
2016 Byrne EF, Sircar R, Miller PS, Hedger G, Luchetti G, Nachtergaele S, Tully MD, Mydock-McGrane L, Covey DF, Rambo RP, Sansom MS, Newstead S, Rohatgi R, Siebold C. Structural basis of Smoothened regulation by its extracellular domains. Nature. PMID 27437577 DOI: 10.1038/Nature18934  1
2016 Zhao Z, Lee RT, Pusapati GV, Iyu A, Rohatgi R, Ingham PW. An essential role for Grk2 in Hedgehog signalling downstream of Smoothened. Embo Reports. PMID 27113758 DOI: 10.15252/Embr.201541532  1
2016 Lebensohn AM, Dubey R, Neitzel LR, Tacchelly-Benites O, Yang E, Marceau CD, Davis EM, Patel BB, Bahrami-Nejad Z, Travaglini KJ, Ahmed Y, Lee E, Carette JE, Rohatgi R. Author response: Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling Elife. DOI: 10.7554/Elife.21459.025  0.88
2016 Lebensohn AM, Dubey R, Neitzel LR, Tacchelly O, Marceau CD, Bahrami Z, Hansen AG, Ahmed Y, Lee E, Carette J, Rohatgi R. Abstract PR05: Systematic forward genetic screens in haploid human cells reveal new players and regulatory mechanisms in Wnt signaling Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Devbiolca15-Pr05  0.88
2015 Marada S, Navarro G, Truong A, Stewart DP, Arensdorf AM, Nachtergaele S, Angelats E, Opferman JT, Rohatgi R, McCormick PJ, Ogden SK. Functional Divergence in the Role of N-Linked Glycosylation in Smoothened Signaling. Plos Genetics. 11: e1005473. PMID 26291458 DOI: 10.1371/Journal.Pgen.1005473  1
2015 Niewiadomski P, Rohatgi R. Rapid Screening of Gli2/3 Mutants Using the Flp-In System. Methods in Molecular Biology (Clifton, N.J.). 1322: 125-30. PMID 26179044 DOI: 10.1007/978-1-4939-2772-2_11  1
2015 Ahrends R, Niewiadomski P, Teruel MN, Rohatgi R. Measuring Gli2 Phosphorylation by Selected Reaction Monitoring Mass Spectrometry. Methods in Molecular Biology (Clifton, N.J.). 1322: 105-23. PMID 26179043 DOI: 10.1007/978-1-4939-2772-2_10  1
2015 Niewiadomski P, Rohatgi R. Measuring Expression Levels of Endogenous Gli Genes by Immunoblotting and Real-Time PCR. Methods in Molecular Biology (Clifton, N.J.). 1322: 81-92. PMID 26179041 DOI: 10.1007/978-1-4939-2772-2_8  1
2015 Kong JH, Yang L, Dessaud E, Chuang K, Moore DM, Rohatgi R, Briscoe J, Novitch BG. Notch activity modulates the responsiveness of neural progenitors to sonic hedgehog signaling. Developmental Cell. 33: 373-87. PMID 25936505 DOI: 10.1016/J.Devcel.2015.03.005  1
2014 Pusapati GV, Rohatgi R. Location, location, and location: compartmentalization of Hedgehog signaling at primary cilia. The Embo Journal. 33: 1852-4. PMID 25037564 DOI: 10.15252/Embj.201489294  1
2014 Guerrero I, Rohatgi R. Frontiers in hedgehog signal transduction. Seminars in Cell & Developmental Biology. 33: 50-1. PMID 24946961 DOI: 10.1016/J.Semcdb.2014.06.009  1
2014 Mukhopadhyay S, Rohatgi R. G-protein-coupled receptors, Hedgehog signaling and primary cilia. Seminars in Cell & Developmental Biology. 33: 63-72. PMID 24845016 DOI: 10.1016/J.Semcdb.2014.05.002  1
2014 Peyrot SM, Nachtergaele S, Luchetti G, Mydock-McGrane LK, Fujiwara H, Scherrer D, Jallouk A, Schlesinger PH, Ory DS, Covey DF, Rohatgi R. Tracking the subcellular fate of 20(s)-hydroxycholesterol with click chemistry reveals a transport pathway to the Golgi. The Journal of Biological Chemistry. 289: 11095-110. PMID 24596093 DOI: 10.1074/Jbc.M113.540351  1
2014 Montgomery SR, Nargizyan T, Meliton V, Nachtergaele S, Rohatgi R, Stappenbeck F, Jung ME, Johnson JS, Aghdasi B, Tian H, Weintraub G, Inoue H, Atti E, Tetradis S, Pereira RC, et al. A novel osteogenic oxysterol compound for therapeutic development to promote bone growth: activation of hedgehog signaling and osteogenesis through smoothened binding. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 29: 1872-85. PMID 24591126 DOI: 10.1002/Jbmr.2213  1
2014 Pusapati GV, Hughes CE, Dorn KV, Zhang D, Sugianto P, Aravind L, Rohatgi R. EFCAB7 and IQCE regulate hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia. Developmental Cell. 28: 483-96. PMID 24582806 DOI: 10.1016/J.Devcel.2014.01.021  1
2014 Niewiadomski P, Kong JH, Ahrends R, Ma Y, Humke EW, Khan S, Teruel MN, Novitch BG, Rohatgi R. Gli protein activity is controlled by multisite phosphorylation in vertebrate Hedgehog signaling. Cell Reports. 6: 168-81. PMID 24373970 DOI: 10.1016/J.Celrep.2013.12.003  1
2014 Earhart CM, Hughes CE, Gaster RS, Ooi CC, Wilson RJ, Zhou LY, Humke EW, Xu L, Wong DJ, Willingham SB, Schwartz EJ, Weissman IL, Jeffrey SS, Neal JW, Rohatgi R, et al. Isolation and mutational analysis of circulating tumor cells from lung cancer patients with magnetic sifters and biochips. Lab On a Chip. 14: 78-88. PMID 23969419 DOI: 10.1039/C3Lc50580D  1
2013 Nachtergaele S, Whalen DM, Mydock LK, Zhao Z, Malinauskas T, Krishnan K, Ingham PW, Covey DF, Siebold C, Rohatgi R. Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling. Elife. 2: e01340. PMID 24171105 DOI: 10.7554/Elife.01340  1
2013 Carragee EJ, Chu G, Rohatgi R, Hurwitz EL, Weiner BK, Yoon ST, Comer G, Kopjar B. Cancer risk after use of recombinant bone morphogenetic protein-2 for spinal arthrodesis. The Journal of Bone and Joint Surgery. American Volume. 95: 1537-45. PMID 24005193 DOI: 10.2106/Jbjs.L.01483  1
2013 Lin YC, Niewiadomski P, Lin B, Nakamura H, Phua SC, Jiao J, Levchenko A, Inoue T, Rohatgi R, Inoue T. Chemically inducible diffusion trap at cilia reveals molecular sieve-like barrier. Nature Chemical Biology. 9: 437-43. PMID 23666116 DOI: 10.1038/Nchembio.1252  1
2012 Dorn KV, Hughes CE, Rohatgi R. A Smoothened-Evc2 complex transduces the Hedgehog signal at primary cilia. Developmental Cell. 23: 823-35. PMID 22981989 DOI: 10.1016/J.Devcel.2012.07.004  1
2012 Briscoe J, Rohatgi R. Singapore signalling: the 2012 hedgehog pathway cocktail. Embo Reports. 13: 580-3. PMID 22688966 DOI: 10.1038/Embor.2012.79  1
2012 Nachtergaele S, Mydock LK, Krishnan K, Rammohan J, Schlesinger PH, Covey DF, Rohatgi R. Oxysterols are allosteric activators of the oncoprotein Smoothened. Nature Chemical Biology. 8: 211-20. PMID 22231273 DOI: 10.1038/Nchembio.765  1
2011 Smith EF, Rohatgi R. Cilia 2010: the surprise organelle of the decade. Science Signaling. 4: mr1. PMID 21224442 DOI: 10.1126/Scisignal.4155Mr1  1
2010 Yavari A, Nagaraj R, Owusu-Ansah E, Folick A, Ngo K, Hillman T, Call G, Rohatgi R, Scott MP, Banerjee U. Role of lipid metabolism in smoothened derepression in hedgehog signaling. Developmental Cell. 19: 54-65. PMID 20643350 DOI: 10.1016/J.Devcel.2010.06.007  1
2010 Rohatgi R, Snell WJ. The ciliary membrane. Current Opinion in Cell Biology. 22: 541-6. PMID 20399632 DOI: 10.1016/J.Ceb.2010.03.010  1
2010 Humke EW, Dorn KV, Milenkovic L, Scott MP, Rohatgi R. The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins. Genes & Development. 24: 670-82. PMID 20360384 DOI: 10.1101/Gad.1902910  1
2009 Milenkovic L, Scott MP, Rohatgi R. Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium. The Journal of Cell Biology. 187: 365-74. PMID 19948480 DOI: 10.1083/Jcb.200907126  1
2009 Rohatgi R, Milenkovic L, Corcoran RB, Scott MP. Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process. Proceedings of the National Academy of Sciences of the United States of America. 106: 3196-201. PMID 19218434 DOI: 10.1073/Pnas.0813373106  1
2008 Rohatgi R, Scott MP. Cell biology. Arrestin' movement in cilia. Science (New York, N.Y.). 320: 1726-7. PMID 18583599 DOI: 10.1126/Science.1160448  1
2007 Rohatgi R, Scott MP. Patching the gaps in Hedgehog signalling. Nature Cell Biology. 9: 1005-9. PMID 17762891 DOI: 10.1038/Ncb435  1
2007 Rohatgi R, Milenkovic L, Scott MP. Patched1 regulates hedgehog signaling at the primary cilium. Science (New York, N.Y.). 317: 372-6. PMID 17641202 DOI: 10.1126/Science.1139740  1
2006 Ho HY, Rohatgi R, Lebensohn AM, Kirschner MW. In vitro reconstitution of cdc42-mediated actin assembly using purified components. Methods in Enzymology. 406: 174-90. PMID 16472658 DOI: 10.1016/S0076-6879(06)06014-9  1
2004 Ho HY, Rohatgi R, Lebensohn AM, Le Ma, Li J, Gygi SP, Kirschner MW. Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex. Cell. 118: 203-16. PMID 15260990 DOI: 10.1016/J.Cell.2004.06.027  1
2004 Feldheim DA, Nakamoto M, Osterfield M, Gale NW, DeChiara TM, Rohatgi R, Yancopoulos GD, Flanagan JG. Loss-of-function analysis of EphA receptors in retinotectal mapping. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 2542-50. PMID 15014130 DOI: 10.1523/Jneurosci.0239-03.2004  1
2002 Eden S, Rohatgi R, Podtelejnikov AV, Mann M, Kirschner MW. Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. Nature. 418: 790-3. PMID 12181570 DOI: 10.1038/Nature00859  1
2001 Ho HY, Rohatgi R, Ma L, Kirschner MW. CR16 forms a complex with N-WASP in brain and is a novel member of a conserved proline-rich actin-binding protein family. Proceedings of the National Academy of Sciences of the United States of America. 98: 11306-11. PMID 11553796 DOI: 10.1073/Pnas.211420498  1
2001 Rohatgi R, Nollau P, Ho HY, Kirschner MW, Mayer BJ. Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway. The Journal of Biological Chemistry. 276: 26448-52. PMID 11340081 DOI: 10.1074/Jbc.M103856200  1
2001 Martinez-Quiles N, Rohatgi R, Antón IM, Medina M, Saville SP, Miki H, Yamaguchi H, Takenawa T, Hartwig JH, Geha RS, Ramesh N. WIP regulates N-WASP-mediated actin polymerization and filopodium formation. Nature Cell Biology. 3: 484-91. PMID 11331876 DOI: 10.1038/35074551  1
2000 Rohatgi R, Ho HY, Kirschner MW. Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate. The Journal of Cell Biology. 150: 1299-310. PMID 10995436 DOI: 10.1083/Jcb.150.6.1299  1
1999 Rohatgi R, Ma L, Miki H, Lopez M, Kirchhausen T, Takenawa T, Kirschner MW. The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Cell. 97: 221-31. PMID 10219243 DOI: 10.1016/S0092-8674(00)80732-1  1
1998 Ma L, Rohatgi R, Kirschner MW. The Arp2/3 complex mediates actin polymerization induced by the small GTP-binding protein Cdc42. Proceedings of the National Academy of Sciences of the United States of America. 95: 15362-7. PMID 9860974 DOI: 10.1073/Pnas.95.26.15362  1
1996 Rohatgi R, Bartel DP, Szostak JW. Nonenzymatic, template-directed ligation of oligoribonucleotides is highly regioselective for the formation of 3'-5' phosphodiester bonds. Journal of the American Chemical Society. 118: 3340-4. PMID 11539268 DOI: 10.1021/Ja9537134  1
1996 Rohatgi R, Bartel DP, Szostak JW. Kinetic and mechanistic analysis of nonenzymatic, template-directed oligoribonucleotide ligation. Journal of the American Chemical Society. 118: 3332-9. PMID 11539267 DOI: 10.1021/Ja953712B  1
1969 Trivedi LK, Massey DB, Rohatgi R. Management of pterygium and its recurrence: by grafting with mucous membrane from the mouth. American Journal of Ophthalmology. 68: 353-4. PMID 5798818  0.01
1969 Trivedi LK, Massey DB, Rohatgi R. Sub-total enucleation and ocular prosthesis. Journal of the All-India Ophthalmological Society. 17: 151-3. PMID 5381758  0.01
1969 Trivedi LK, Massey LB, Rohatgi R. Dacryocystorhinostomy with intubation. Journal of the All-India Ophthalmological Society. 17: 263-5. PMID 5375516  0.01
1969 Trivedi LK, Massey DB, Rohatgi R. Grafts from living eyes for lamellar keratoplasty. American Journal of Ophthalmology. 67: 917-9. PMID 4891698  0.01
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