Isaac T Schiefer - Related publications

University of Toledo, Toledo, OH, United States 
CNS drug discovery
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27 most relevant papers in past 60 days:
Year Citation  Score
2022 Charif SE, Vassallu MF, Salvañal L, Igaz LM. Protein synthesis modulation as a therapeutic approach for amyotrophic lateral sclerosis and frontotemporal dementia. Neural Regeneration Research. 17: 1423-1430. PMID 34916412 DOI: 10.4103/1673-5374.330593   
2022 Ruan C, Ning W, Liu Z, Zhang X, Fang Z, Li Y, Dang Y, Xue Y, Ye M. Precipitate-Supported Thermal Proteome Profiling Coupled with Deep Learning for Comprehensive Screening of Drug Target Proteins. Acs Chemical Biology. PMID 34989232 DOI: 10.1021/acschembio.1c00936   
2022 Needs SH, Bootman MD, Grotzke JE, Kramer HB, Allman SA. Off-target inhibition of NGLY1 by the poly-caspase inhibitor Z-VAD-fmk induces cellular autophagy. The Febs Journal. PMID 34995415 DOI: 10.1111/febs.16345   
2022 Wu YH, Zhang Y, Fang DQ, Chen J, Wang JA, Jiang L, Lv ZF. Characterization of the Composition and Biological Activity of the Venom from Fabricius, a Wasp from South China. Toxins. 14. PMID 35051036 DOI: 10.3390/toxins14010059   
2022 Glumoff T, Sowa ST, Lehtiö L. Assay technologies facilitating drug discovery for ADP-ribosyl writers, readers and erasers. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 44: e2100240. PMID 34816463 DOI: 10.1002/bies.202100240   
2022 Ye S, Hsiung CH, Tang Y, Zhang X. Visualizing the Multistep Process of Protein Aggregation in Live Cells. Accounts of Chemical Research. PMID 35040316 DOI: 10.1021/acs.accounts.1c00648   
2022 Nubbemeyer B, Paul George AA, Kühl T, Pepanian A, Beck MS, Maghraby R, Shetab Boushehri M, Muehlhaupt M, Pfeil EM, Annala SK, Ammer H, Imhof D, Pei D. Targeting Gαi/s Proteins with Peptidyl Nucleotide Exchange Modulators. Acs Chemical Biology. PMID 35042325 DOI: 10.1021/acschembio.1c00929   
2022 Vanderschuren K, Arranz-Gibert P, Khang M, Hadar D, Gaudin A, Yang F, Folta-Stogniew E, Saltzman WM, Amiram M, Isaacs FJ. Tuning protein half-life in mouse using sequence-defined biopolymers functionalized with lipids. Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 35046019 DOI: 10.1073/pnas.2103099119   
2022 Saadi S, Saari N, Ghazali HM, Abdulkarim SM, Hamid AA, Anwar F. Gluten proteins: Enzymatic modification, functional and therapeutic properties. Journal of Proteomics. 251: 104395. PMID 34673267 DOI: 10.1016/j.jprot.2021.104395   
2022 Zaidi S, Bhardwaj T, Somvanshi P, Khan AU. Proteomic Characterization and Target Identification Against Streptococcus mutans Under Bacitracin Stress Conditions Using LC-MS and Subtractive Proteomics. The Protein Journal. PMID 34989956 DOI: 10.1007/s10930-021-10038-1   
2022 Hua Y, Song XN, Feng Z, Wu XJ, Kittler J, Yu DJ. CPInformer for Efficient and Robust Compound-Protein Interaction Prediction. Ieee/Acm Transactions On Computational Biology and Bioinformatics. PMID 35044921 DOI: 10.1109/TCBB.2022.3144008   
2022 Humphreys PG, Atkinson SJ, Bamborough P, Bit RA, Chung CW, Craggs PD, Cutler L, Davis R, Ferrie A, Gong G, Gordon LJ, Gray M, Harrison LA, Hayhow TG, Haynes A, et al. Design, Synthesis, and Characterization of I-BET567, a Pan-Bromodomain and Extra Terminal (BET) Bromodomain Oral Candidate. Journal of Medicinal Chemistry. PMID 34995458 DOI: 10.1021/acs.jmedchem.1c01747   
2022 Grams RJ, Hsu KL. Reactive chemistry for covalent probe and therapeutic development. Trends in Pharmacological Sciences. PMID 34998611 DOI: 10.1016/   
2022 Lieser RM, Li Q, Chen W, Sullivan MO. Incorporation of Endosomolytic Peptides with Varying Disruption Mechanisms into EGFR-Targeted Protein Conjugates: The Effect on Intracellular Protein Delivery and EGFR Specificity in Breast Cancer Cells. Molecular Pharmaceutics. PMID 35040326 DOI: 10.1021/acs.molpharmaceut.1c00788   
2022 Desch K, Schuman EM, Langer JD. Quantifying phosphorylation dynamics in primary neuronal cultures using LC-MS/MS. Star Protocols. 3: 101063. PMID 35005645 DOI: 10.1016/j.xpro.2021.101063   
2022 Cable J, Weber-Ban E, Clausen T, Walters KJ, Sharon M, Finley DJ, Gu Y, Hanna J, Feng Y, Martens S, Simonsen A, Hansen M, Zhang H, Goodwin JM, Reggio A, et al. Targeted protein degradation: from small molecules to complex organelles-a Keystone Symposia report. Annals of the New York Academy of Sciences. PMID 35000205 DOI: 10.1111/nyas.14745   
2022 Bhattacharya R, Chatterjee A, Chatterjee S, Saha NC. Commonly used surfactants sodium dodecyl sulphate, cetylpyridinium chloride and sodium laureth sulphate and their effects on antioxidant defence system and oxidative stress indices in Cyprinus carpio L.: an integrated in silico and in vivo approach. Environmental Science and Pollution Research International. PMID 34993779 DOI: 10.1007/s11356-021-17864-x   
2022 Riera-Tur I, Schäfer T, Hornburg D, Mishra A, da Silva Padilha M, Fernández-Mosquera L, Feigenbutz D, Auer P, Mann M, Baumeister W, Klein R, Meissner F, Raimundo N, Fernández-Busnadiego R, Dudanova I. Amyloid-like aggregating proteins cause lysosomal defects in neurons via gain-of-function toxicity. Life Science Alliance. 5. PMID 34933920 DOI: 10.26508/lsa.202101185   
2022 Huang B, Zhou L, Liu R, Wang L, Xue S, Shi Y, Jeong GH, Jeong IH, Li S, Yin J, Cai J. Activation of E6AP/UBE3A-Mediated Protein Ubiquitination and Degradation Pathways by a Cyclic γ-AA Peptide. Journal of Medicinal Chemistry. PMID 35045253 DOI: 10.1021/acs.jmedchem.1c01922   
2022 Cavalcante JDS, de Almeida CAS, Clasen MA, da Silva EL, de Barros LC, Marinho AD, Rossini BC, Marino CL, Carvalho PC, Jorge RJB, Dos Santos LD. A fingerprint of plasma proteome alteration after local tissue damage induced by Bothrops leucurus snake venom in mice. Journal of Proteomics. 253: 104464. PMID 34954398 DOI: 10.1016/j.jprot.2021.104464   
2022 Hou J, Chen X, Jiang N, Wang Y, Cui Y, Ma L, Lin Y, Lu Y. Toward efficient multiple-site incorporation of unnatural amino acids using cell-free translation system. Synthetic and Systems Biotechnology. 7: 522-532. PMID 35024479 DOI: 10.1016/j.synbio.2021.12.007   
2022 Wang C, Zhang Y, Wang J, Xing D. VHL-based PROTACs as potential therapeutic agents: Recent progress and perspectives. European Journal of Medicinal Chemistry. 227: 113906. PMID 34656901 DOI: 10.1016/j.ejmech.2021.113906   
2022 Wang S, Li J, Wang Y. M2PP: a novel computational model for predicting drug-targeted pathogenic proteins. Bmc Bioinformatics. 23: 7. PMID 34983358 DOI: 10.1186/s12859-021-04522-9   
2022 Sharma KB, Aggarwal S, Yadav AK, Vrati S, Kalia M. Studying Autophagy Using a TMT-Based Quantitative Proteomics Approach. Methods in Molecular Biology (Clifton, N.J.). 2445: 183-203. PMID 34972993 DOI: 10.1007/978-1-0716-2071-7_12   
2022 Borzova VA, Chebotareva NA, Sluchanko NN, Kleymenov SY, Markossian KA, Kurganov BI. The mechanism of thermal aggregation of glutamate dehydrogenase. The effect of chemical chaperones. Biochimie. PMID 35041856 DOI: 10.1016/j.biochi.2022.01.004   
2022 Katow H, Vasudevan D, Ryoo HD. Drosophila Unfolded Protein Response (UPR) Assays In Vitro and In Vivo. Methods in Molecular Biology (Clifton, N.J.). 2378: 261-277. PMID 34985706 DOI: 10.1007/978-1-0716-1732-8_17   
2022 Clarke J, Grogan H, Fitzpatrick D, Kavanagh K. Analysis of the effect of Bacillus velezensis culture filtrate on the growth and proteome of Cladobotryum mycophilum. Fungal Biology. 126: 11-19. PMID 34930555 DOI: 10.1016/j.funbio.2021.09.003