James R. Halpert - Publications

Affiliations: 
Pharmacy University of California, San Diego, La Jolla, CA 

28 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Shah MB, Liu J, Zhang Q, Stout CD, Halpert JR. Halogen-π Interactions in the Cytochrome P450 Active Site: Structural Insights into Human CYP2B6 Substrate Selectivity. Acs Chemical Biology. PMID 28368100 DOI: 10.1021/acschembio.7b00056  0.36
2016 Shah MB, Jang HH, Wilderman PR, Lee D, Li S, Zhang Q, Stout CD, Halpert JR. Effect of detergent binding on cytochrome P450 2B4 structure as analyzed by X-ray crystallography and deuterium-exchange mass spectrometry. Biophysical Chemistry. 216: 1-8. PMID 27280734 DOI: 10.1016/j.bpc.2016.05.007  0.36
2016 Liu J, Shah MB, Zhang Q, Stout CD, Halpert JR, Wilderman PR. Coumarin Derivatives as Substrate Probes of Mammalian Cytochromes P450 2B4 and 2B6: Assessing the Importance of 7-Alkoxy Chain Length, Halogen Substitution, and Non-Active Site Mutations. Biochemistry. PMID 26982502 DOI: 10.1021/acs.biochem.5b01330  0.36
2016 Shah MB, Liu J, Huo L, Zhang Q, Dearing MD, Wilderman PR, Szklarz GD, Stout CD, Halpert JR. Structure-Function Analysis of Mammalian CYP2B Enzymes using 7-Substituted Coumarin Derivatives as Probes: Utility of Crystal Structures and Molecular Modeling in Understanding Xenobiotic Metabolism. Molecular Pharmacology. PMID 26826176 DOI: 10.1124/mol.115.102111  0.36
2015 Shah MB, Wilderman PR, Liu J, Jang HH, Zhang Q, Stout CD, Halpert JR. Structural and biophysical characterization of human cytochromes P450 2B6 and 2A6 bound to volatile hydrocarbons: analysis and comparison. Molecular Pharmacology. 87: 649-59. PMID 25585967 DOI: 10.1124/mol.114.097014  0.36
2013 Wilderman PR, Shah MB, Jang HH, Stout CD, Halpert JR. Structural and thermodynamic basis of (+)-α-pinene binding to human cytochrome P450 2B6. Journal of the American Chemical Society. 135: 10433-40. PMID 23786449 DOI: 10.1021/ja403042k  0.36
2013 Shah MB, Kufareva I, Pascual J, Zhang Q, Stout CD, Halpert JR. A structural snapshot of CYP2B4 in complex with paroxetine provides insights into ligand binding and clusters of conformational states. The Journal of Pharmacology and Experimental Therapeutics. 346: 113-20. PMID 23633618 DOI: 10.1124/jpet.113.204776  0.36
2013 Lee SC, Bennett BC, Hong WX, Fu Y, Baker KA, Marcoux J, Robinson CV, Ward AB, Halpert JR, Stevens RC, Stout CD, Yeager MJ, Zhang Q. Steroid-based facial amphiphiles for stabilization and crystallization of membrane proteins. Proceedings of the National Academy of Sciences of the United States of America. 110: E1203-11. PMID 23479627 DOI: 10.1073/pnas.1221442110  0.36
2013 Zhang H, Gay SC, Shah M, Foroozesh M, Liu J, Osawa Y, Zhang Q, Stout CD, Halpert JR, Hollenberg PF. Potent mechanism-based inactivation of cytochrome P450 2B4 by 9-ethynylphenanthrene: Implications for allosteric modulation of cytochrome P450 catalysis Biochemistry. 52: 355-364. PMID 23276288 DOI: 10.1021/bi301567z  0.48
2012 Shimshoni JA, Roberts AG, Scian M, Topletz AR, Blankert SA, Halpert JR, Nelson WL, Isoherranen N. Stereoselective formation and metabolism of 4-hydroxy-retinoic Acid enantiomers by cytochrome p450 enzymes. The Journal of Biological Chemistry. 287: 42223-32. PMID 23071109 DOI: 10.1074/jbc.M112.404475  0.48
2012 Shah MB, Wilderman PR, Pascual J, Zhang Q, Stout CD, Halpert JR. Conformational adaptation of human cytochrome P450 2B6 and rabbit cytochrome P450 2B4 revealed upon binding multiple amlodipine molecules. Biochemistry. 51: 7225-38. PMID 22909231 DOI: 10.1021/bi300894z  0.36
2012 Wilderman PR, Gay SC, Jang HH, Zhang Q, Stout CD, Halpert JR. Investigation by site-directed mutagenesis of the role of cytochrome P450 2B4 non-active-site residues in protein-ligand interactions based on crystal structures of the ligand-bound enzyme. The Febs Journal. 279: 1607-20. PMID 22051155 DOI: 10.1111/j.1742-4658.2011.08411.x  0.48
2011 Roberts AG, Yang J, Halpert JR, Nelson SD, Thummel KT, Atkins WM. The structural basis for homotropic and heterotropic cooperativity of midazolam metabolism by human cytochrome P450 3A4. Biochemistry. 50: 10804-18. PMID 21992114 DOI: 10.1021/bi200924t  0.48
2011 Shah MB, Pascual J, Zhang Q, Stout CD, Halpert JR. Structures of cytochrome P450 2B6 bound to 4-benzylpyridine and 4-(4-nitrobenzyl)pyridine: insight into inhibitor binding and rearrangement of active site side chains. Molecular Pharmacology. 80: 1047-55. PMID 21875942 DOI: 10.1124/mol.111.074427  0.36
2011 Gay SC, Zhang H, Wilderman PR, Roberts AG, Liu T, Li S, Lin HL, Zhang Q, Woods VL, Stout CD, Hollenberg PF, Halpert JR. Structural analysis of mammalian cytochrome P450 2B4 covalently bound to the mechanism-based inactivator tert-butylphenylacetylene: insight into partial enzymatic activity. Biochemistry. 50: 4903-11. PMID 21510666 DOI: 10.1021/bi200482g  0.48
2011 Roberts AG, Sjögren SE, Fomina N, Vu KT, Almutairi A, Halpert JR. NMR-derived models of amidopyrine and its metabolites in complexes with rabbit cytochrome P450 2B4 reveal a structural mechanism of sequential N-dealkylation. Biochemistry. 50: 2123-34. PMID 21375273 DOI: 10.1021/bi101797v  0.48
2010 Gay SC, Roberts AG, Halpert JR. Structural features of cytochromes P450 and ligands that affect drug metabolism as revealed by X-ray crystallography and NMR. Future Medicinal Chemistry. 2: 1451-68. PMID 21103389  0.48
2010 Wilderman PR, Shah MB, Liu T, Li S, Hsu S, Roberts AG, Goodlett DR, Zhang Q, Woods VL, Stout CD, Halpert JR. Plasticity of cytochrome P450 2B4 as investigated by hydrogen-deuterium exchange mass spectrometry and X-ray crystallography. The Journal of Biological Chemistry. 285: 38602-11. PMID 20880847 DOI: 10.1074/jbc.M110.180646  0.48
2010 Gay SC, Roberts AG, Maekawa K, Talakad JC, Hong WX, Zhang Q, Stout CD, Halpert JR. Structures of cytochrome P450 2B4 complexed with the antiplatelet drugs ticlopidine and clopidogrel . Biochemistry. 49: 8709-20. PMID 20815363 DOI: 10.1021/bi100914z  0.48
2010 Gay SC, Shah MB, Talakad JC, Maekawa K, Roberts AG, Wilderman PR, Sun L, Yang JY, Huelga SC, Hong WX, Zhang Q, Stout CD, Halpert JR. Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution. Molecular Pharmacology. 77: 529-38. PMID 20061448 DOI: 10.1124/mol.109.062570  0.48
2009 Gay SC, Sun L, Maekawa K, Halpert JR, Stout CD. Crystal structures of cytochrome P450 2B4 in complex with the inhibitor 1-biphenyl-4-methyl-1H-imidazole: ligand-induced structural response through alpha-helical repositioning. Biochemistry. 48: 4762-71. PMID 19397311 DOI: 10.1021/bi9003765  0.48
2008 Muralidhara BK, Sun L, Negi S, Halpert JR. Thermodynamic fidelity of the mammalian cytochrome P450 2B4 active site in binding substrates and inhibitors. Journal of Molecular Biology. 377: 232-45. PMID 18241887 DOI: 10.1016/j.jmb.2007.12.068  0.36
2007 Zhao Y, Sun L, Muralidhara BK, Kumar S, White MA, Stout CD, Halpert JR. Structural and thermodynamic consequences of 1-(4-chlorophenyl)imidazole binding to cytochrome P450 2B4. Biochemistry. 46: 11559-67. PMID 17887776 DOI: 10.1021/bi7011614  0.36
2007 Kumar S, Zhao Y, Sun L, Negi SS, Halpert JR, Muralidhara BK. Rational engineering of human cytochrome P450 2B6 for enhanced expression and stability: Importance of a Leu264→Phe substitution Molecular Pharmacology. 72: 1191-1199. PMID 17715394 DOI: 10.1124/mol.107.039693  0.36
2007 Sun L, Chen CS, Waxman DJ, Liu H, Halpert JR, Kumar S. Re-engineering cytochrome P450 2B11dH for enhanced metabolism of several substrates including the anti-cancer prodrugs cyclophosphamide and ifosfamide. Archives of Biochemistry and Biophysics. 458: 167-74. PMID 17254539 DOI: 10.1016/j.abb.2006.12.021  0.36
2006 Kumar S, Sun L, Liu H, Muralidhara BK, Halpert JR. Engineering mammalian cytochrome P450 2B1 by directed evolution for enhanced catalytic tolerance to temperature and dimethyl sulfoxide. Protein Engineering, Design & Selection : Peds. 19: 547-54. PMID 17050590 DOI: 10.1093/protein/gzl042  0.36
2006 Zhao Y, White MA, Muralidhara BK, Sun L, Halpert JR, Stout CD. Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: insight into P450 conformational plasticity and membrane interaction. The Journal of Biological Chemistry. 281: 5973-81. PMID 16373351 DOI: 10.1074/jbc.M511464200  0.36
2004 Scott EE, White MA, He YA, Johnson EF, Stout CD, Halpert JR. Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-A resolution: insight into the range of P450 conformations and the coordination of redox partner binding. The Journal of Biological Chemistry. 279: 27294-301. PMID 15100217 DOI: 10.1074/jbc.M403349200  0.36
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