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Brian J. Bacskai - Publications

Affiliations: 
Neurology Massachusetts General Hospital, Boston, MA 
Area:
Alzheimer's
Website:
http://dms.hms.harvard.edu/neuroscience/fac/Bacskai.php

158 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Kastanenka KV, Calvo-Rodriguez M, Hou SS, Zhou H, Takeda S, Arbel-Ornath M, Lariviere A, Lee YF, Kim A, Hawkes JM, Logan R, Feng D, Chen X, Gomperts SN, Bacskai BJ. Frequency-dependent exacerbation of Alzheimer's disease neuropathophysiology. Scientific Reports. 9: 8964. PMID 31221985 DOI: 10.1038/s41598-019-44964-z  0.8
2019 van Veluw SJ, Scherlek AA, Freeze WM, Ter Telgte A, van der Kouwe AJ, Bacskai BJ, Frosch MP, Greenberg SM. Different microvascular alterations underlie microbleeds and microinfarcts. Annals of Neurology. PMID 31152566 DOI: 10.1002/ana.25512  0.6
2019 Schlunk F, Böhm M, Boulouis G, Qin T, Arbel M, Tamim I, Fischer P, Bacskai BJ, Frosch MP, Endres M, Greenberg SM, Ayata C. Secondary Bleeding During Acute Experimental Intracerebral Hemorrhage. Stroke. 50: 1210-1215. PMID 31009358 DOI: 10.1161/STROKEAHA.118.021732  0.6
2019 van Veluw SJ, Reijmer YD, van der Kouwe AJ, Charidimou A, Riley GA, Leemans A, Bacskai BJ, Frosch MP, Viswanathan A, Greenberg SM. Histopathology of diffusion imaging abnormalities in cerebral amyloid angiopathy. Neurology. PMID 30700595 DOI: 10.1212/WNL.0000000000007005  0.6
2019 Freeze WM, Bacskai BJ, Frosch MP, Jacobs HIL, Backes WH, Greenberg SM, van Veluw SJ. Blood-Brain Barrier Leakage and Microvascular Lesions in Cerebral Amyloid Angiopathy. Stroke. STROKEAHA118023788. PMID 30661497 DOI: 10.1161/STROKEAHA.118.023788  0.6
2018 Hou S, Bacskai BJ, Kumar A. The Resolution Matrix in Tomographic Multiplexing: Optimization of Inter-parameter Cross-talk, Relative Quantitation and Localization. Ieee Transactions On Bio-Medical Engineering. PMID 30582520 DOI: 10.1109/TBME.2018.2889043  0.36
2018 Ji M, Arbel M, Zhang L, Freudiger CW, Hou SS, Lin D, Yang X, Bacskai BJ, Xie XS. Label-free imaging of amyloid plaques in Alzheimer's disease with stimulated Raman scattering microscopy. Science Advances. 4: eaat7715. PMID 30456301 DOI: 10.1126/sciadv.aat7715  0.52
2018 Kelly P, Hudry E, Hou SS, Bacskai BJ. Two Photon Imaging of Astrocytic Structure and Function in Alzheimer's Disease. Frontiers in Aging Neuroscience. 10: 219. PMID 30072889 DOI: 10.3389/fnagi.2018.00219  0.72
2018 Funane T, Hou SS, Zoltowska KM, van Veluw SJ, Berezovska O, Kumar ATN, Bacskai BJ. Selective plane illumination microscopy (SPIM) with time-domain fluorescence lifetime imaging microscopy (FLIM) for volumetric measurement of cleared mouse brain samples. The Review of Scientific Instruments. 89: 053705. PMID 29864842 DOI: 10.1063/1.5018846  0.76
2018 Wang X, Kastanenka KV, Arbel-Ornath M, Commins C, Kuzuya A, Lariviere AJ, Krafft GA, Hefti F, Jerecic J, Bacskai BJ. An acute functional screen identifies an effective antibody targeting amyloid-β oligomers based on calcium imaging. Scientific Reports. 8: 4634. PMID 29545579 DOI: 10.1038/s41598-018-22979-2  0.8
2018 Pagnier GJ, Kastanenka KV, Sohn M, Choi S, Choi SH, Soh H, Bacskai BJ. Novel botanical drug DA-9803 prevents deficits in Alzheimer's mouse models. Alzheimer's Research & Therapy. 10: 11. PMID 29378621 DOI: 10.1186/s13195-018-0338-2  0.8
2017 Charidimou A, Boulouis G, Gurol ME, Ayata C, Bacskai BJ, Frosch MP, Viswanathan A, Greenberg SM. Emerging concepts in sporadic cerebral amyloid angiopathy. Brain : a Journal of Neurology. PMID 28334869 DOI: 10.1093/brain/awx047  0.6
2017 Arbel-Ornath M, Hudry E, Boivin JR, Hashimoto T, Takeda S, Kuchibhotla KV, Hou S, Lattarulo CR, Belcher AM, Shakerdge N, Trujillo PB, Muzikansky A, Betensky RA, Hyman BT, Bacskai BJ. Soluble oligomeric amyloid-β induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain. Molecular Neurodegeneration. 12: 27. PMID 28327181 DOI: 10.1186/s13024-017-0169-9  0.96
2017 Maesako M, Horlacher J, Zoltowska KM, Kastanenka KV, Kara E, Svirsky S, Keller LJ, Li X, Hyman BT, Bacskai BJ, Berezovska O. Pathogenic PS1 phosphorylation at Ser367. Elife. 6. PMID 28132667 DOI: 10.7554/eLife.19720  0.96
2017 Kastanenka KV, Hou SS, Shakerdge N, Logan R, Feng D, Wegmann S, Chopra V, Hawkes JM, Chen X, Bacskai BJ. Optogenetic Restoration of Disrupted Slow Oscillations Halts Amyloid Deposition and Restores Calcium Homeostasis in an Animal Model of Alzheimer's Disease. Plos One. 12: e0170275. PMID 28114405 DOI: 10.1371/journal.pone.0170275  0.8
2016 Hou SS, Bacskai BJ, Kumar AT. Comparison of tomographic fluorescence spectral and lifetime multiplexing. Optics Letters. 41: 5337-5340. PMID 27842127  0.52
2016 Kastanenka KV, Bussiere T, Shakerdge N, Qian F, Weinreb PH, Rhodes K, Bacskai BJ. Immunotherapy with aducanumab restores calcium homeostasis in Tg2576 mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 27810931 DOI: 10.1523/JNEUROSCI.2080-16.2016  0.8
2016 Hou SS, Bacskai BJ, Kumar AT. Optimal estimator for tomographic fluorescence lifetime multiplexing. Optics Letters. 41: 1352-5. PMID 27192234  0.52
2016 Ramos-Rodriguez JJ, Spires-Jones T, Pooler AM, Lechuga-Sancho AM, Bacskai BJ, Garcia-Alloza M. Progressive Neuronal Pathology and Synaptic Loss Induced by Prediabetes and Type 2 Diabetes in a Mouse Model of Alzheimer's Disease. Molecular Neurobiology. PMID 27177549 DOI: 10.1007/s12035-016-9921-3  0.96
2016 Bakker EN, Bacskai BJ, Arbel-Ornath M, Aldea R, Bedussi B, Morris AW, Weller RO, Carare RO. Lymphatic Clearance of the Brain: Perivascular, Paravascular and Significance for Neurodegenerative Diseases. Cellular and Molecular Neurobiology. PMID 26993512 DOI: 10.1007/s10571-015-0273-8  0.8
2015 Galea E, Morrison W, Hudry E, Arbel-Ornath M, Bacskai BJ, Gómez-Isla T, Stanley HE, Hyman BT. Topological analyses in APP/PS1 mice reveal that astrocytes do not migrate to amyloid-β plaques. Proceedings of the National Academy of Sciences of the United States of America. PMID 26644572 DOI: 10.1073/pnas.1516779112  0.96
2015 Zhao L, Arbel-Ornath M, Wang X, Betensky RA, Greenberg SM, Frosch MP, Bacskai BJ. Matrix metalloproteinase 9-mediated intracerebral hemorrhage induced by cerebral amyloid angiopathy. Neurobiology of Aging. PMID 26248866 DOI: 10.1016/j.neurobiolaging.2015.07.016  0.96
2015 Chu W, Zhou D, Gaba V, Liu J, Li S, Peng X, Xu J, Dhavale D, Bagchi DP, d'Avignon A, Shakerdge NB, Bacskai BJ, Tu Z, Kotzbauer PT, Mach RH. Design, Synthesis, and Characterization of 3-(Benzylidene)indolin-2-one Derivatives as Ligands for α-Synuclein Fibrils. Journal of Medicinal Chemistry. 58: 6002-17. PMID 26177091 DOI: 10.1021/acs.jmedchem.5b00571  0.8
2015 Lillis KP, Wang Z, Mail M, Zhao GQ, Berdichevsky Y, Bacskai B, Staley KJ. Evolution of Network Synchronization during Early Epileptogenesis Parallels Synaptic Circuit Alterations. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 9920-34. PMID 26156993 DOI: 10.1523/JNEUROSCI.4007-14.2015  0.96
2015 Eikermann-Haerter K, Arbel-Ornath M, Yalcin N, Yu ES, Kuchibhotla KV, Yuzawa I, Hudry E, Willard CR, Climov M, Keles F, Belcher AM, Sengul B, Negro A, Rosen IA, Arreguin A, ... ... Bacskai BJ, et al. Abnormal synaptic Ca(2+) homeostasis and morphology in cortical neurons of familial hemiplegic migraine type 1 mutant mice. Annals of Neurology. 78: 193-210. PMID 26032020 DOI: 10.1002/ana.24449  0.84
2015 Chu W, Zhou D, Gaba V, Liu J, Li S, Peng X, Xu J, Dhavale D, Bagchi DP, D'Avignon A, Shakerdge NB, Bacskai BJ, Tu Z, Kotzbauer PT, Mach RH. Design, Synthesis, and Characterization of 3-(Benzylidene)indolin-2-one Derivatives as Ligands for α-Synuclein Fibrils Journal of Medicinal Chemistry. 58: 6002-6017. DOI: 10.1021/acs.jmedchem.5b00571  0.96
2015 Eikermann-Haerter K, Arbel-Ornath M, Yalcin N, Yu ES, Kuchibhotla KV, Yuzawa I, Hudry E, Willard CR, Climov M, Keles F, Belcher AM, Sengul B, Negro A, Rosen IA, Arreguin A, ... ... Bacskai BJ, et al. Abnormal synaptic Ca2+ homeostasis and morphology in cortical neurons of familial hemiplegic migraine type 1 mutant mice Annals of Neurology. 78: 193-210. DOI: 10.1002/ana.24449  0.96
2014 Grishchuk Y, Sri S, Rudinskiy N, Ma W, Stember KG, Cottle MW, Sapp E, Difiglia M, Muzikansky A, Betensky RA, Wong AM, Bacskai BJ, Hyman BT, Kelleher RJ, Cooper JD, et al. Behavioral deficits, early gliosis, dysmyelination and synaptic dysfunction in a mouse model of mucolipidosis IV. Acta Neuropathologica Communications. 2: 133. PMID 25200117 DOI: 10.1186/s40478-014-0133-7  0.96
2014 Glykys J, Dzhala V, Egawa K, Balena T, Saponjian Y, Kuchibhotla KV, Bacskai BJ, Kahle KT, Zeuthen T, Staley KJ. Response to comments on "Local impermeant anions establish the neuronal chloride concentration". Science (New York, N.Y.). 345: 1130. PMID 25190789 DOI: 10.1126/science.1253146  0.96
2014 Gu C, Chang J, Shchedrina VA, Pham VA, Hartwig JH, Suphamungmee W, Lehman W, Hyman BT, Bacskai BJ, Sever S. Regulation of dynamin oligomerization in cells: the role of dynamin-actin interactions and its GTPase activity. Traffic (Copenhagen, Denmark). 15: 819-38. PMID 24891099 DOI: 10.1111/tra.12178  0.96
2014 Guo Y, Yuan H, Claudio NM, Kura S, Shakerdge N, Mempel TR, Bacskai BJ, Josephson L. PEG-like nanoprobes: multimodal, pharmacokinetically and optically tunable nanomaterials. Plos One. 9: e95406. PMID 24781778 DOI: 10.1371/journal.pone.0095406  0.96
2014 Hou SS, Rice WL, Bacskai BJ, Kumar AT. Tomographic lifetime imaging using combined early- and late-arriving photons. Optics Letters. 39: 1165-8. PMID 24690697 DOI: 10.1364/OL.39.001165  0.96
2014 Glykys J, Dzhala V, Egawa K, Balena T, Saponjian Y, Kuchibhotla KV, Bacskai BJ, Kahle KT, Zeuthen T, Staley KJ. Local impermeant anions establish the neuronal chloride concentration. Science (New York, N.Y.). 343: 670-5. PMID 24503855 DOI: 10.1126/science.1245423  0.96
2014 Kuchibhotla KV, Wegmann S, Kopeikina KJ, Hawkes J, Rudinskiy N, Andermann ML, Spires-Jones TL, Bacskai BJ, Hyman BT. Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo. Proceedings of the National Academy of Sciences of the United States of America. 111: 510-4. PMID 24368848 DOI: 10.1073/pnas.1318807111  0.96
2014 Wang X, Arbel-Ornath M, Wegmann SK, Kastanenka KV, Bacskai BJ. In vivo imaging in neurodegenerative diseases Advances in Intravital Microscopy: From Basic to Clinical Research. 45-80. DOI: 10.1007/978-94-017-9361-2_3  0.96
2013 Garcia-Alloza M, Borrelli LA, Thyssen DH, Hickman SE, El Khoury J, Bacskai BJ. Four-dimensional microglia response to anti-Aβ treatment in APP/PS1xCX3CR1/GFP mice. Intravital. 2. PMID 28944103 DOI: 10.4161/intv.25693  0.96
2013 Kopeikina KJ, Wegmann S, Pitstick R, Carlson GA, Bacskai BJ, Betensky RA, Hyman BT, Spires-Jones TL. Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy. Plos One. 8: e80834. PMID 24278327 DOI: 10.1371/journal.pone.0080834  0.96
2013 Xie H, Guan J, Borrelli LA, Xu J, Serrano-Pozo A, Bacskai BJ. Mitochondrial alterations near amyloid plaques in an Alzheimer's disease mouse model. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 17042-51. PMID 24155308 DOI: 10.1523/JNEUROSCI.1836-13.2013  0.96
2013 Arbel-Ornath M, Hudry E, Eikermann-Haerter K, Hou S, Gregory JL, Zhao L, Betensky RA, Frosch MP, Greenberg SM, Bacskai BJ. Interstitial fluid drainage is impaired in ischemic stroke and Alzheimer's disease mouse models. Acta Neuropathologica. 126: 353-64. PMID 23818064 DOI: 10.1007/s00401-013-1145-2  0.96
2013 Neal KL, Shakerdge NB, Hou SS, Klunk WE, Mathis CA, Nesterov EE, Swager TM, McLean PJ, Bacskai BJ. Development and screening of contrast agents for in vivo imaging of Parkinson's disease. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. 15: 585-95. PMID 23624948 DOI: 10.1007/s11307-013-0634-y  0.96
2013 Xie H, Hou S, Jiang J, Sekutowicz M, Kelly J, Bacskai BJ. Rapid cell death is preceded by amyloid plaque-mediated oxidative stress. Proceedings of the National Academy of Sciences of the United States of America. 110: 7904-9. PMID 23610434 DOI: 10.1073/pnas.1217938110  0.96
2013 Ramos-Rodriguez JJ, Pacheco-Herrero M, Thyssen D, Murillo-Carretero MI, Berrocoso E, Spires-Jones TL, Bacskai BJ, Garcia-Alloza M. Rapid β-amyloid deposition and cognitive impairment after cholinergic denervation in APP/PS1 mice. Journal of Neuropathology and Experimental Neurology. 72: 272-85. PMID 23481704 DOI: 10.1097/NEN.0b013e318288a8dd  0.96
2012 Hashimoto T, Serrano-Pozo A, Hori Y, Adams KW, Takeda S, Banerji AO, Mitani A, Joyner D, Thyssen DH, Bacskai BJ, Frosch MP, Spires-Jones TL, Finn MB, Holtzman DM, Hyman BT. Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 15181-92. PMID 23100439 DOI: 10.1523/JNEUROSCI.1542-12.2012  0.96
2012 Gregory JL, Prada CM, Fine SJ, Garcia-Alloza M, Betensky RA, Arbel-Ornath M, Greenberg SM, Bacskai BJ, Frosch MP. Reducing available soluble β-amyloid prevents progression of cerebral amyloid angiopathy in transgenic mice. Journal of Neuropathology and Experimental Neurology. 71: 1009-17. PMID 23095848 DOI: 10.1097/NEN.0b013e3182729845  0.96
2012 Serrano-Pozo A, Mielke ML, Muzitansky A, Gómez-Isla T, Growdon JH, Bacskai BJ, Betensky RA, Frosch MP, Hyman BT. Stable size distribution of amyloid plaques over the course of Alzheimer disease. Journal of Neuropathology and Experimental Neurology. 71: 694-701. PMID 22805771 DOI: 10.1097/NEN.0b013e31825e77de  0.96
2012 Nabuurs RJ, Rutgers KS, Welling MM, Metaxas A, de Backer ME, Rotman M, Bacskai BJ, van Buchem MA, van der Maarel SM, van der Weerd L. In vivo detection of amyloid-β deposits using heavy chain antibody fragments in a transgenic mouse model for Alzheimer's disease. Plos One. 7: e38284. PMID 22675537 DOI: 10.1371/journal.pone.0038284  0.96
2012 Wu HY, Hudry E, Hashimoto T, Uemura K, Fan ZY, Berezovska O, Grosskreutz CL, Bacskai BJ, Hyman BT. Distinct dendritic spine and nuclear phases of calcineurin activation after exposure to amyloid-β revealed by a novel fluorescence resonance energy transfer assay. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 5298-309. PMID 22496575 DOI: 10.1523/JNEUROSCI.0227-12.2012  0.96
2012 Hudry E, Wu HY, Arbel-Ornath M, Hashimoto T, Matsouaka R, Fan Z, Spires-Jones TL, Betensky RA, Bacskai BJ, Hyman BT. Inhibition of the NFAT pathway alleviates amyloid β neurotoxicity in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 3176-92. PMID 22378890 DOI: 10.1523/JNEUROSCI.6439-11.2012  0.96
2012 Lee JH, Bacskai BJ, Ayata C. Genetic animal models of cerebral vasculopathies. Progress in Molecular Biology and Translational Science. 105: 25-55. PMID 22137428 DOI: 10.1016/B978-0-12-394596-9.00002-0  0.96
2011 Garcia-Alloza M, Gregory J, Kuchibhotla KV, Fine S, Wei Y, Ayata C, Frosch MP, Greenberg SM, Bacskai BJ. Cerebrovascular lesions induce transient β-amyloid deposition. Brain : a Journal of Neurology. 134: 3697-707. PMID 22120142 DOI: 10.1093/brain/awr300  0.96
2011 Jones PB, Adams KW, Rozkalne A, Spires-Jones TL, Hshieh TT, Hashimoto T, von Armin CA, Mielke M, Bacskai BJ, Hyman BT. Apolipoprotein E: isoform specific differences in tertiary structure and interaction with amyloid-β in human Alzheimer brain. Plos One. 6: e14586. PMID 21297948 DOI: 10.1371/journal.pone.0014586  0.96
2011 Spires-Jones TL, de Calignon A, Meyer-Luehmann M, Bacskai BJ, Hyman BT. Monitoring protein aggregation and toxicity in Alzheimer's disease mouse models using in vivo imaging. Methods (San Diego, Calif.). 53: 201-7. PMID 21163350 DOI: 10.1016/j.ymeth.2010.12.009  0.96
2011 Rutgers KS, van Remoortere A, van Buchem MA, Verrips CT, Greenberg SM, Bacskai BJ, Frosch MP, van Duinen SG, Maat-Schieman ML, van der Maarel SM. Differential recognition of vascular and parenchymal beta amyloid deposition. Neurobiology of Aging. 32: 1774-83. PMID 20015576 DOI: 10.1016/j.neurobiolaging.2009.11.012  0.96
2010 Dzhala VI, Kuchibhotla KV, Glykys JC, Kahle KT, Swiercz WB, Feng G, Kuner T, Augustine GJ, Bacskai BJ, Staley KJ. Progressive NKCC1-dependent neuronal chloride accumulation during neonatal seizures. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 11745-61. PMID 20810895 DOI: 10.1523/JNEUROSCI.1769-10.2010  0.96
2010 Raymond SB, Boas DA, Bacskai BJ, Kumar AT. Lifetime-based tomographic multiplexing. Journal of Biomedical Optics. 15: 046011. PMID 20799813 DOI: 10.1117/1.3469797  0.96
2010 de Calignon A, Fox LM, Pitstick R, Carlson GA, Bacskai BJ, Spires-Jones TL, Hyman BT. Caspase activation precedes and leads to tangles. Nature. 464: 1201-4. PMID 20357768 DOI: 10.1038/nature08890  0.96
2010 Wu HY, Hudry E, Hashimoto T, Kuchibhotla K, Rozkalne A, Fan Z, Spires-Jones T, Xie H, Arbel-Ornath M, Grosskreutz CL, Bacskai BJ, Hyman BT. Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 2636-49. PMID 20164348 DOI: 10.1523/JNEUROSCI.4456-09.2010  0.96
2010 Coma M, Serenó L, Da Rocha-Souto B, Scotton TC, España J, Sánchez MB, Rodríguez M, Agulló J, Guardia-Laguarta C, Garcia-Alloza M, Borrelli LA, Clarimón J, Lleó A, Bacskai BJ, Saura CA, et al. Triflusal reduces dense-core plaque load, associated axonal alterations and inflammatory changes, and rescues cognition in a transgenic mouse model of Alzheimer's disease. Neurobiology of Disease. 38: 482-91. PMID 20149872 DOI: 10.1016/j.nbd.2010.01.019  0.96
2010 Garcia-Alloza M, Borrelli LA, Hyman BT, Bacskai BJ. Antioxidants have a rapid and long-lasting effect on neuritic abnormalities in APP:PS1 mice. Neurobiology of Aging. 31: 2058-68. PMID 19124175 DOI: 10.1016/j.neurobiolaging.2008.11.006  0.96
2009 Uemura K, Lill CM, Li X, Peters JA, Ivanov A, Fan Z, DeStrooper B, Bacskai BJ, Hyman BT, Berezovska O. Allosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio. Plos One. 4: e7893. PMID 19924286 DOI: 10.1371/journal.pone.0007893  0.96
2009 Meyer-Luehmann M, Mielke M, Spires-Jones TL, Stoothoff W, Jones P, Bacskai BJ, Hyman BT. A reporter of local dendritic translocation shows plaque- related loss of neural system function in APP-transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 12636-40. PMID 19812338 DOI: 10.1523/JNEUROSCI.1948-09.2009  0.96
2009 Ran C, Xu X, Raymond SB, Ferrara BJ, Neal K, Bacskai BJ, Medarova Z, Moore A. Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in vivo detection of amyloid-beta deposits. Journal of the American Chemical Society. 131: 15257-61. PMID 19807070 DOI: 10.1021/ja9047043  0.96
2009 Raymond SB, Kumar AT, Boas DA, Bacskai BJ. Optimal parameters for near infrared fluorescence imaging of amyloid plaques in Alzheimer's disease mouse models. Physics in Medicine and Biology. 54: 6201-16. PMID 19794239 DOI: 10.1088/0031-9155/54/20/011  0.96
2009 Glykys J, Dzhala VI, Kuchibhotla KV, Feng G, Kuner T, Augustine G, Bacskai BJ, Staley KJ. Differences in cortical versus subcortical GABAergic signaling: a candidate mechanism of electroclinical uncoupling of neonatal seizures. Neuron. 63: 657-72. PMID 19755108 DOI: 10.1016/j.neuron.2009.08.022  0.96
2009 Stoothoff W, Jones PB, Spires-Jones TL, Joyner D, Chhabra E, Bercury K, Fan Z, Xie H, Bacskai B, Edd J, Irimia D, Hyman BT. Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport. Journal of Neurochemistry. 111: 417-27. PMID 19686388 DOI: 10.1111/j.1471-4159.2009.06316.x  0.96
2009 Kumar AT, Chung E, Raymond SB, van de Water JA, Shah K, Fukumura D, Jain RK, Bacskai BJ, Boas DA. Feasibility of in vivo imaging of fluorescent proteins using lifetime contrast. Optics Letters. 34: 2066-8. PMID 19572001 DOI: 10.1364/OL.34.002066  0.96
2009 Garcia-Alloza M, Prada C, Lattarulo C, Fine S, Borrelli LA, Betensky R, Greenberg SM, Frosch MP, Bacskai BJ. Matrix metalloproteinase inhibition reduces oxidative stress associated with cerebral amyloid angiopathy in vivo in transgenic mice. Journal of Neurochemistry. 109: 1636-47. PMID 19457117 DOI: 10.1111/j.1471-4159.2009.06096.x  0.96
2009 Garcia-Alloza M, Subramanian M, Thyssen D, Borrelli LA, Fauq A, Das P, Golde TE, Hyman BT, Bacskai BJ. Existing plaques and neuritic abnormalities in APP:PS1 mice are not affected by administration of the gamma-secretase inhibitor LY-411575. Molecular Neurodegeneration. 4: 19. PMID 19419556 DOI: 10.1186/1750-1326-4-19  0.96
2009 Atwood C, Bacskai B, Kuchibhotla K, Bezprozvanny I, Chakroborty S, Fagan T, Foskett K, Green K, Goussakov I, Moyer J, Michno K, Rybalchenko V, Stutzmann B, Villalobos C. Alzheimer research forum live discussion: Calcium in AD pathogenesis Journal of Alzheimer's Disease. 16: 909-917. PMID 19387122 DOI: 10.3233/JAD-2009-1026  0.96
2009 Kuchibhotla KV, Lattarulo CR, Hyman BT, Bacskai BJ. Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice. Science (New York, N.Y.). 323: 1211-5. PMID 19251629 DOI: 10.1126/science.1169096  0.96
2009 Jiang Y, Borrelli L, Bacskai BJ, Kanaoka Y, Boyce JA. P2Y6 receptors require an intact cysteinyl leukotriene synthetic and signaling system to induce survival and activation of mast cells. Journal of Immunology (Baltimore, Md. : 1950). 182: 1129-37. PMID 19124756  0.96
2009 Spires-Jones TL, Mielke ML, Rozkalne A, Meyer-Luehmann M, de Calignon A, Bacskai BJ, Schenk D, Hyman BT. Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease. Neurobiology of Disease. 33: 213-20. PMID 19028582 DOI: 10.1016/j.nbd.2008.10.011  0.96
2009 Jones PB, Bacskai BJ, Hyman BT. Chapter 11 Biomedical FRET-FLIM applications Laboratory Techniques in Biochemistry and Molecular Biology. 33: 447-474. DOI: 10.1016/S0075-7535(08)00011-9  0.96
2008 Raymond SB, Skoch J, Hills ID, Nesterov EE, Swager TM, Bacskai BJ. Erratum to Smart optical probes for near-infrared fluorescence imaging of Alzheimer's disease pathology. European Journal of Nuclear Medicine and Molecular Imaging. 35: 1032. PMID 28289876 DOI: 10.1007/s00259-008-0749-6  0.72
2008 Stoothoff WH, Bacskai BJ, Hyman BT. Monitoring tau-tubulin interactions utilizing second harmonic generation in living neurons. Journal of Biomedical Optics. 13: 064039. PMID 19123685 DOI: 10.1117/1.3050422  0.96
2008 Koenigsknecht-Talboo J, Meyer-Luehmann M, Parsadanian M, Garcia-Alloza M, Finn MB, Hyman BT, Bacskai BJ, Holtzman DM. Rapid microglial response around amyloid pathology after systemic anti-Abeta antibody administration in PDAPP mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 14156-64. PMID 19109498 DOI: 10.1523/JNEUROSCI.4147-08.2008  0.96
2008 Mandal AK, Jones PB, Bair AM, Christmas P, Miller D, Yamin TT, Wisniewski D, Menke J, Evans JF, Hyman BT, Bacskai B, Chen M, Lee DM, Nikolic B, Soberman RJ. The nuclear membrane organization of leukotriene synthesis. Proceedings of the National Academy of Sciences of the United States of America. 105: 20434-9. PMID 19075240 DOI: 10.1073/pnas.0808211106  0.96
2008 Kumar AT, Raymond SB, Dunn AK, Bacskai BJ, Boas DA. A time domain fluorescence tomography system for small animal imaging. Ieee Transactions On Medical Imaging. 27: 1152-63. PMID 18672432 DOI: 10.1109/TMI.2008.918341  0.96
2008 Kuchibhotla KV, Goldman ST, Lattarulo CR, Wu HY, Hyman BT, Bacskai BJ. Abeta plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks. Neuron. 59: 214-25. PMID 18667150 DOI: 10.1016/j.neuron.2008.06.008  0.96
2008 Raymond SB, Treat LH, Dewey JD, McDannold NJ, Hynynen K, Bacskai BJ. Ultrasound enhanced delivery of molecular imaging and therapeutic agents in Alzheimer's disease mouse models. Plos One. 3: e2175. PMID 18478109 DOI: 10.1371/journal.pone.0002175  0.96
2008 Kumar AT, Raymond SB, Bacskai BJ, Boas DA. Comparison of frequency-domain and time-domain fluorescence lifetime tomography. Optics Letters. 33: 470-2. PMID 18311295 DOI: 10.1364/OL.33.000470  0.96
2008 Meyer-Luehmann M, Spires-Jones TL, Prada C, Garcia-Alloza M, de Calignon A, Rozkalne A, Koenigsknecht-Talboo J, Holtzman DM, Bacskai BJ, Hyman BT. Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease. Nature. 451: 720-4. PMID 18256671 DOI: 10.1038/nature06616  0.96
2008 Raymond SB, Skoch J, Hills ID, Nesterov EE, Swager TM, Bacskai BJ. Smart optical probes for near-infrared fluorescence imaging of Alzheimer's disease pathology. European Journal of Nuclear Medicine and Molecular Imaging. 35: S93-8. PMID 18236039 DOI: 10.1007/s00259-007-0708-7  0.96
2008 Spires-Jones TL, de Calignon A, Matsui T, Zehr C, Pitstick R, Wu HY, Osetek JD, Jones PB, Bacskai BJ, Feany MB, Carlson GA, Ashe KH, Lewis J, Hyman BT. In vivo imaging reveals dissociation between caspase activation and acute neuronal death in tangle-bearing neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 862-7. PMID 18216194 DOI: 10.1523/JNEUROSCI.3072-08.2008  0.96
2008 Raymond SB, Skoch J, Hills ID, Nesterov EE, Swager TM, Bacskai BJ. Smart optical probes for near-infrared fluorescence imaging of Alzheimer's disease pathology (European Journal of Nuclear Medicine and Molecular Imaging (2008) 35, SUPPL. 1, 35, (593-598) DOI: 10.1007/s00259-007-0708-7) European Journal of Nuclear Medicine and Molecular Imaging. 35: 1032. DOI: 10.1007/s00259-008-0749-6  0.96
2007 Garcia-Alloza M, Ferrara BJ, Dodwell SA, Hickey GA, Hyman BT, Bacskai BJ. A limited role for microglia in antibody mediated plaque clearance in APP mice. Neurobiology of Disease. 28: 286-92. PMID 17822910 DOI: 10.1016/j.nbd.2007.07.019  0.96
2007 Spires-Jones TL, Meyer-Luehmann M, Osetek JD, Jones PB, Stern EA, Bacskai BJ, Hyman BT. Impaired spine stability underlies plaque-related spine loss in an Alzheimer's disease mouse model. The American Journal of Pathology. 171: 1304-11. PMID 17717139 DOI: 10.2353/ajpath.2007.070055  0.96
2007 Jiang Y, Borrelli LA, Kanaoka Y, Bacskai BJ, Boyce JA. CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells. Blood. 110: 3263-70. PMID 17693579 DOI: 10.1182/blood-2007-07-100453  0.96
2007 Shin HK, Jones PB, Garcia-Alloza M, Borrelli L, Greenberg SM, Bacskai BJ, Frosch MP, Hyman BT, Moskowitz MA, Ayata C. Age-dependent cerebrovascular dysfunction in a transgenic mouse model of cerebral amyloid angiopathy. Brain : a Journal of Neurology. 130: 2310-9. PMID 17638859 DOI: 10.1093/brain/awm156  0.96
2007 Garcia-Alloza M, Borrelli LA, Rozkalne A, Hyman BT, Bacskai BJ. Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model. Journal of Neurochemistry. 102: 1095-104. PMID 17472706 DOI: 10.1111/j.1471-4159.2007.04613.x  0.96
2007 Bacskai BJ, Frosch MP, Freeman SH, Raymond SB, Augustinack JC, Johnson KA, Irizarry MC, Klunk WE, Mathis CA, Dekosky ST, Greenberg SM, Hyman BT, Growdon JH. Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report. Archives of Neurology. 64: 431-4. PMID 17353389 DOI: 10.1001/archneur.64.3.431  0.96
2007 Raymond SB, Skoch J, Bacskai BJ, Hynynen K. Modular design for in vivo optical imaging and ultrasound treatment in the murine brain. Ieee Transactions On Ultrasonics, Ferroelectrics, and Frequency Control. 54: 431-4. PMID 17328340 DOI: 10.1109/TUFFC.2007.257  0.96
2007 Prada CM, Garcia-Alloza M, Betensky RA, Zhang-Nunes SX, Greenberg SM, Bacskai BJ, Frosch MP. Antibody-mediated clearance of amyloid-beta peptide from cerebral amyloid angiopathy revealed by quantitative in vivo imaging. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 1973-80. PMID 17314293 DOI: 10.1523/JNEUROSCI.5426-06.2007  0.96
2007 Hillman EM, Devor A, Bouchard MB, Dunn AK, Krauss GW, Skoch J, Bacskai BJ, Dale AM, Boas DA. Depth-resolved optical imaging and microscopy of vascular compartment dynamics during somatosensory stimulation. Neuroimage. 35: 89-104. PMID 17222567 DOI: 10.1016/j.neuroimage.2006.11.032  0.96
2007 Raymond SB, Skoch J, Hynynen K, Bacskai BJ. Multiphoton imaging of ultrasound/Optison mediated cerebrovascular effects in vivo. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 27: 393-403. PMID 16685254 DOI: 10.1038/sj.jcbfm.9600336  0.96
2007 Kumar ATN, Raymond SB, Boas DA, Bacskai BJ. A direct approach to time domain fluorescence tomography based on asymptotic lifetime analysis Progress in Biomedical Optics and Imaging - Proceedings of Spie. 6434. DOI: 10.1117/12.699692  0.96
2007 Hwa KS, Garcia-Alloza M, Jones PB, Borrelli L, Bacskai BJ, Frosch MP, Hyman BT, Moskowitz MA, Ayata C. Age-dependent cerebrovascular dysfunction in Tg2576 transgenic mouse model of human cerebral amyloid angiopathy Journal of Cerebral Blood Flow and Metabolism. 27: BP29-02U.  0.96
2006 Kumar AT, Raymond SB, Boverman G, Boas DA, Bacskai BJ. Time resolved fluorescence tomography of turbid media based on lifetime contrast. Optics Express. 14: 12255-70. PMID 19529654 DOI: 10.1364/OE.14.012255  0.96
2006 Jones PB, Herl L, Berezovska O, Kumar AT, Bacskai BJ, Hyman BT. Time-domain fluorescent plate reader for cell based protein-protein interaction and protein conformation assays. Journal of Biomedical Optics. 11: 054024. PMID 17092173 DOI: 10.1117/1.2363367  0.96
2006 Garcia-Alloza M, Dodwell SA, Meyer-Luehmann M, Hyman BT, Bacskai BJ. Plaque-derived oxidative stress mediates distorted neurite trajectories in the Alzheimer mouse model. Journal of Neuropathology and Experimental Neurology. 65: 1082-9. PMID 17086105 DOI: 10.1097/01.jnen.0000240468.12543.af  0.96
2006 Garcia-Alloza M, Robbins EM, Zhang-Nunes SX, Purcell SM, Betensky RA, Raju S, Prada C, Greenberg SM, Bacskai BJ, Frosch MP. Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease. Neurobiology of Disease. 24: 516-24. PMID 17029828 DOI: 10.1016/j.nbd.2006.08.017  0.96
2006 Sever S, Skoch J, Newmyer S, Ramachandran R, Ko D, McKee M, Bouley R, Ausiello D, Hyman BT, Bacskai BJ. Physical and functional connection between auxilin and dynamin during endocytosis. The Embo Journal. 25: 4163-74. PMID 16946707 DOI: 10.1038/sj.emboj.7601298  0.96
2006 Guo S, Wang S, Kim WJ, Lee SR, Frosch MP, Bacskai BJ, Greenberg SM, Lo EH. Effects of apoE isoforms on beta-amyloid-induced matrix metalloproteinase-9 in rat astrocytes. Brain Research. 1111: 222-6. PMID 16919608 DOI: 10.1016/j.brainres.2006.06.041  0.96
2006 Skoch J, Hyman BT, Bacskai BJ. Preclinical characterization of amyloid imaging probes with multiphoton microscopy. Journal of Alzheimer's Disease : Jad. 9: 401-7. PMID 16914878  0.96
2006 Robbins EM, Betensky RA, Domnitz SB, Purcell SM, Garcia-Alloza M, Greenberg C, Rebeck GW, Hyman BT, Greenberg SM, Frosch MP, Bacskai BJ. Kinetics of cerebral amyloid angiopathy progression in a transgenic mouse model of Alzheimer disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 365-71. PMID 16407531 DOI: 10.1523/JNEUROSCI.3854-05.2006  0.96
2006 Raymond S, Skoch J, Bacskai B, Hynynen K. Multiphoton imaging of ultrasound bioeffects in the murine brain Aip Conference Proceedings. 829: 276-280. DOI: 10.1063/1.2205481  0.96
2005 Sever S, Skoch J, Bacskai BJ, Newmyer SL. Assays and functional properties of auxilin-dynamin interactions. Methods in Enzymology. 404: 570-85. PMID 16413301 DOI: 10.1016/S0076-6879(05)04050-4  0.96
2005 Kumar AT, Skoch J, Bacskai BJ, Boas DA, Dunn AK. Fluorescence-lifetime-based tomography for turbid media. Optics Letters. 30: 3347-9. PMID 16389827 DOI: 10.1364/OL.30.003347  0.96
2005 Spires TL, Meyer-Luehmann M, Stern EA, McLean PJ, Skoch J, Nguyen PT, Bacskai BJ, Hyman BT. Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 7278-87. PMID 16079410 DOI: 10.1523/JNEUROSCI.1879-05.2005  0.96
2005 Nesterov EE, Skoch J, Hyman BT, Klunk WE, Bacskai BJ, Swager TM. In vivo optical imaging of amyloid aggregates in brain: design of fluorescent markers. Angewandte Chemie (International Ed. in English). 44: 5452-6. PMID 16059955 DOI: 10.1002/anie.200500845  0.96
2005 Xiang Z, Nesterov EE, Skoch J, Lin T, Hyman BT, Swager TM, Bacskai BJ, Reeves SA. Detection of myelination using a novel histological probe. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 53: 1511-6. PMID 16046669 DOI: 10.1369/jhc.5A6704.2005  0.96
2005 Domnitz SB, Robbins EM, Hoang AW, Garcia-Alloza M, Hyman BT, Rebeck GW, Greenberg SM, Bacskai BJ, Frosch MP. Progression of cerebral amyloid angiopathy in transgenic mouse models of Alzheimer disease. Journal of Neuropathology and Experimental Neurology. 64: 588-94. PMID 16042310  0.96
2005 Skoch J, Hickey GA, Kajdasz ST, Hyman BT, Bacskai BJ. In vivo imaging of amyloid-beta deposits in mouse brain with multiphoton microscopy. Methods in Molecular Biology (Clifton, N.J.). 299: 349-63. PMID 15980616  0.96
2005 Golde TE, Bacskai BJ. Bringing amyloid into focus. Nature Biotechnology. 23: 552-4. PMID 15877070 DOI: 10.1038/nbt0505-552  0.96
2005 Skoch J, Dunn A, Hyman BT, Bacskai BJ. Development of an optical approach for noninvasive imaging of Alzheimer's disease pathology. Journal of Biomedical Optics. 10: 11007. PMID 15847573 DOI: 10.1117/1.1846075  0.96
2005 Berezovska O, Lleo A, Herl LD, Frosch MP, Stern EA, Bacskai BJ, Hyman BT. Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 3009-17. PMID 15772361 DOI: 10.1523/JNEUROSCI.0364-05.2005  0.96
2005 von Arnim CA, Kinoshita A, Peltan ID, Tangredi MM, Herl L, Lee BM, Spoelgen R, Hshieh TT, Ranganathan S, Battey FD, Liu CX, Bacskai BJ, Sever S, Irizarry MC, Strickland DK, et al. The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate. The Journal of Biological Chemistry. 280: 17777-85. PMID 15749709 DOI: 10.1074/jbc.M414248200  0.96
2005 Brendza RP, Bacskai BJ, Cirrito JR, Simmons KA, Skoch JM, Klunk WE, Mathis CA, Bales KR, Paul SM, Hyman BT, Holtzman DM. Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice. The Journal of Clinical Investigation. 115: 428-33. PMID 15668737 DOI: 10.1172/JCI23269  0.96
2005 Kumar ATN, Skoch J, Hammond FL, Dunn AK, Boas DA, Bacskai BJ. Time resolved fluorescence imaging in diffuse media Proceedings of Spie - the International Society For Optical Engineering. 6009. DOI: 10.1117/12.630990  0.96
2004 Garcia-Alloza M, Bacskai BJ. Techniques for brain imaging in vivo. Neuromolecular Medicine. 6: 65-78. PMID 15781977 DOI: 10.1385/NMM:6:1:065  0.96
2004 Lleó A, Berezovska O, Herl L, Raju S, Deng A, Bacskai BJ, Frosch MP, Irizarry M, Hyman BT. Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation. Nature Medicine. 10: 1065-6. PMID 15448688 DOI: 10.1038/nm1112  0.96
2004 Pasinelli P, Belford ME, Lennon N, Bacskai BJ, Hyman BT, Trotti D, Brown RH. Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria. Neuron. 43: 19-30. PMID 15233914 DOI: 10.1016/j.neuron.2004.06.021  0.96
2004 Stern EA, Bacskai BJ, Hickey GA, Attenello FJ, Lombardo JA, Hyman BT. Cortical synaptic integration in vivo is disrupted by amyloid-beta plaques. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 4535-40. PMID 15140924 DOI: 10.1523/JNEUROSCI.0462-04.2004  0.96
2004 Mandal AK, Skoch J, Bacskai BJ, Hyman BT, Christmas P, Miller D, Yamin TT, Xu S, Wisniewski D, Evans JF, Soberman RJ. The membrane organization of leukotriene synthesis. Proceedings of the National Academy of Sciences of the United States of America. 101: 6587-92. PMID 15084748 DOI: 10.1073/pnas.0308523101  0.96
2004 Bacskai BJ, Skoch J, Hickey GA, Berezovska O, Hyman BT. Multiphoton imaging in mouse models of Alzheimer's disease Proceedings of Spie - the International Society For Optical Engineering. 5323: 71-76. DOI: 10.1117/12.537940  0.96
2004 Levene MJ, Dombeck DA, Williams RM, Skoch J, Hickey GA, Kasischke KA, Molloy RP, Ingelsson M, Stern EA, Klucken J, Bacskai BJ, Zipfel WR, Hyman BT, Webb WW. In vivo multiphoton microscopy of deep tissue with gradient index lenses Proceedings of Spie - the International Society For Optical Engineering. 5323: 291-296. DOI: 10.1117/12.537285  0.96
2003 Klunk WE, Engler H, Nordberg A, Bacskai BJ, Wang Y, Price JC, Bergström M, Hyman BT, LÃ¥ngström B, Mathis CA. Imaging the pathology of Alzheimer's disease: amyloid-imaging with positron emission tomography. Neuroimaging Clinics of North America. 13: 781-9, ix. PMID 15024961 DOI: 10.1016/S1052-5149(03)00092-3  0.96
2003 Lombardo JA, Stern EA, McLellan ME, Kajdasz ST, Hickey GA, Bacskai BJ, Hyman BT. Amyloid-beta antibody treatment leads to rapid normalization of plaque-induced neuritic alterations. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 10879-83. PMID 14645482  0.96
2003 Ramdya P, Skoch J, Bacskai BJ, Hyman BT, Berezovska O. Activated Notch1 associates with a presenilin-1/gamma-secretase docking site. Journal of Neurochemistry. 87: 843-50. PMID 14622115 DOI: 10.1046/j.1471-4159.2003.02030.x  0.96
2003 Bacskai BJ, Hickey GA, Skoch J, Kajdasz ST, Wang Y, Huang GF, Mathis CA, Klunk WE, Hyman BT. Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-beta ligand in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 100: 12462-7. PMID 14517353 DOI: 10.1073/pnas.2034101100  0.96
2003 Lennon NJ, Kho A, Bacskai BJ, Perlmutter SL, Hyman BT, Brown RH. Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing. The Journal of Biological Chemistry. 278: 50466-73. PMID 14506282 DOI: 10.1074/jbc.M307247200  0.96
2003 Bacskai BJ, Skoch J, Hickey GA, Allen R, Hyman BT. Fluorescence resonance energy transfer determinations using multiphoton fluorescence lifetime imaging microscopy to characterize amyloid-beta plaques. Journal of Biomedical Optics. 8: 368-75. PMID 12880341 DOI: 10.1117/1.1584442  0.96
2003 Berezovska O, Bacskai BJ, Hyman BT. Monitoring proteins in intact cells. Science of Aging Knowledge Environment : Sage Ke. 2003: PE14. PMID 12844526  0.96
2003 Berezovska O, Ramdya P, Skoch J, Wolfe MS, Bacskai BJ, Hyman BT. Amyloid precursor protein associates with a nicastrin-dependent docking site on the presenilin 1-gamma-secretase complex in cells demonstrated by fluorescence lifetime imaging. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 4560-6. PMID 12805296  0.96
2003 McLellan ME, Kajdasz ST, Hyman BT, Bacskai BJ. In vivo imaging of reactive oxygen species specifically associated with thioflavine S-positive amyloid plaques by multiphoton microscopy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 2212-7. PMID 12657680  0.96
2003 Greenberg SM, Bacskai BJ, Hyman BT. Alzheimer disease's double-edged vaccine. Nature Medicine. 9: 389-90. PMID 12640449 DOI: 10.1038/nm847  0.96
2003 D'Amore JD, Kajdasz ST, McLellan ME, Bacskai BJ, Stern EA, Hyman BT. In vivo multiphoton imaging of a transgenic mouse model of Alzheimer disease reveals marked thioflavine-S-associated alterations in neurite trajectories. Journal of Neuropathology and Experimental Neurology. 62: 137-45. PMID 12578223  0.96
2002 Bacskai BJ, Hyman BT. Alzheimer's disease: what multiphoton microscopy teaches us. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 8: 386-90. PMID 12374422  0.96
2002 Klunk WE, Bacskai BJ, Mathis CA, Kajdasz ST, McLellan ME, Frosch MP, Debnath ML, Holt DP, Wang Y, Hyman BT. Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative. Journal of Neuropathology and Experimental Neurology. 61: 797-805. PMID 12230326  0.96
2002 Bacskai BJ, Kajdasz ST, McLellan ME, Games D, Seubert P, Schenk D, Hyman BT. Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 7873-8. PMID 12223540  0.96
2002 Bacskai BJ, Klunk WE, Mathis CA, Hyman BT. Imaging amyloid-beta deposits in vivo. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 22: 1035-41. PMID 12218409 DOI: 10.1097/00004647-200209000-00001  0.96
2002 Mathis CA, Bacskai BJ, Kajdasz ST, McLellan ME, Frosch MP, Hyman BT, Holt DP, Wang Y, Huang GF, Debnath ML, Klunk WE. A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain. Bioorganic & Medicinal Chemistry Letters. 12: 295-8. PMID 11814781 DOI: 10.1016/S0960-894X(01)00734-X  0.96
2001 Kimchi EY, Kajdasz S, Bacskai BJ, Hyman BT. Analysis of cerebral amyloid angiopathy in a transgenic mouse model of Alzheimer disease using in vivo multiphoton microscopy. Journal of Neuropathology and Experimental Neurology. 60: 274-9. PMID 11245211  0.96
2001 Bacskai BJ, Kajdasz ST, Christie RH, Carter C, Games D, Seubert P, Schenk D, Hyman BT. Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy. Nature Medicine. 7: 369-72. PMID 11231639 DOI: 10.1038/85525  0.96
2001 Christie RH, Bacskai BJ, Zipfel WR, Williams RM, Kajdasz ST, Webb WW, Hyman BT. Growth arrest of individual senile plaques in a model of Alzheimer's disease observed by in vivo multiphoton microscopy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 858-64. PMID 11157072  0.96
2001 Bacskai BJ, Kajdasz ST, Christie RH, Zipfel WR, Williams RM, Kasischke KA, Webb WW, Hyman BT. Chronic imaging of amyloid plaques in the live mouse brain using multiphoton microscopy Proceedings of Spie - the International Society For Optical Engineering. 4262: 125-133. DOI: 10.1117/12.424546  0.96
2000 Bacskai BJ, Xia MQ, Strickland DK, Rebeck GW, Hyman BT. The endocytic receptor protein LRP also mediates neuronal calcium signaling via N-methyl-D-aspartate receptors. Proceedings of the National Academy of Sciences of the United States of America. 97: 11551-6. PMID 11016955 DOI: 10.1073/pnas.200238297  0.96
2000 Xia MQ, Bacskai BJ, Knowles RB, Qin SX, Hyman BT. Expression of the chemokine receptor CXCR3 on neurons and the elevated expression of its ligand IP-10 in reactive astrocytes: in vitro ERK1/2 activation and role in Alzheimer's disease. Journal of Neuroimmunology. 108: 227-35. PMID 10900358 DOI: 10.1016/S0165-5728(00)00285-X  0.96
1998 Grant ER, Bacskai BJ, Anegawa NJ, Pleasure DE, Lynch DR. Opposing contributions of NR1 and NR2 to protein kinase C modulation of NMDA receptors. Journal of Neurochemistry. 71: 1471-81. PMID 9751180  0.96
1997 Grant ER, Bacskai BJ, Pleasure DE, Pritchett DB, Gallagher MJ, Kendrick SJ, Kricka LJ, Lynch DR. N-methyl-D-aspartate receptors expressed in a nonneuronal cell line mediate subunit-specific increases in free intracellular calcium. The Journal of Biological Chemistry. 272: 647-56. PMID 8995308 DOI: 10.1074/jbc.272.1.647  0.96
1995 Bacskai BJ, Wallén P, Lev-Ram V, Grillner S, Tsien RY. Activity-related calcium dynamics in lamprey motoneurons as revealed by video-rate confocal microscopy. Neuron. 14: 19-28. PMID 7826636 DOI: 10.1016/0896-6273(95)90237-6  0.96
1994 Ranganathan R, Bacskai BJ, Tsien RY, Zuker CS. Cytosolic calcium transients: spatial localization and role in Drosophila photoreceptor cell function. Neuron. 13: 837-48. PMID 7946332 DOI: 10.1016/0896-6273(94)90250-X  0.96
1994 Civitelli R, Bacskai BJ, Mahaut-Smith MP, Adams SR, Avioli LV, Tsien RY. Single-cell analysis of cyclic AMP response to parathyroid hormone in osteoblastic cells. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 9: 1407-17. PMID 7817824 DOI: 10.1002/jbmr.5650090912  0.96
1993 Tsien RY, Bacskai BJ, Adams SR. FRET for studying intracellular signalling. Trends in Cell Biology. 3: 242-5. PMID 14731760 DOI: 10.1016/0962-8924(93)90124-J  0.96
1993 Adams SR, Bacskai BJ, Hochner B, Kaang BK, Kandel ER, Mahaut-Smith M, Tsien RY. Confocal imaging of cAMP signals in Aplysia neurons. The Japanese Journal of Physiology. 43: S91-3. PMID 8271521  0.96
1993 Bacskai BJ, Hochner B, Mahaut-Smith M, Adams SR, Kaang BK, Kandel ER, Tsien RY. Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysia sensory neurons. Science (New York, N.Y.). 260: 222-6. PMID 7682336  0.96
1991 Pizzonia JH, Gesek FA, Kennedy SM, Coutermarsh BA, Bacskai BJ, Friedman PA. Immunomagnetic separation, primary culture, and characterization of cortical thick ascending limb plus distal convoluted tubule cells from mouse kidney. In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association. 27: 409-16. PMID 1649164  0.96
1990 Bacskai BJ, Friedman PA. Activation of latent Ca2+ channels in renal epithelial cells by parathyroid hormone. Nature. 347: 388-91. PMID 1699128 DOI: 10.1038/347388a0  0.96
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