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Stephen C. Blacklow - Publications

Pathology Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States 
structure and function of cell surface receptor molecules

125 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Feng R, Wang Y, Ramachandran V, Ma Q, May MM, Li M, Zhou JX, Xu X, Xu K, Fang S, Xia W, Sui D, Liu H, Gao X, Prieto V, ... Blacklow SC, et al. Characterization of novel neutralizing mouse monoclonal antibody JM1-24-3 developed against MUC18 in metastatic melanoma. Journal of Experimental & Clinical Cancer Research : Cr. 39: 273. PMID 33278894 DOI: 10.1186/s13046-020-01722-8  0.48
2020 Pan L, Lemieux ME, Thomas T, Rogers JM, Lipper CH, Lee W, Johnson C, Sholl LM, South AP, Marto JA, Adelmant GO, Blacklow SC, Aster JC. , a DNA damage response gene, is required for Notch-mediated induction of squamous cell differentiation. Elife. 9. PMID 32936072 DOI: 10.7554/eLife.58081  0.52
2020 Lehal R, Zaric J, Vigolo M, Urech C, Frismantas V, Zangger N, Cao L, Berger A, Chicote I, Loubéry S, Choi SH, Koch U, Blacklow SC, Palmer HG, Bornhauser B, et al. Pharmacological disruption of the Notch transcription factor complex. Proceedings of the National Academy of Sciences of the United States of America. PMID 32601208 DOI: 10.1073/pnas.1922606117  0.52
2020 Rogers JM, Guo B, Egan ED, Aster JC, Adelman K, Blacklow SC. MAML1-dependent Notch responsive genes exhibit differing co-factor requirements for transcriptional activation. Molecular and Cellular Biology. PMID 32179552 DOI: 10.1128/MCB.00014-20  0.52
2020 Rome KS, Stein SJ, Kurachi M, Petrovic J, Schwartz GW, Mack EA, Uljon S, Wu WW, DeHart AG, McClory SE, Xu L, Gimotty PA, Blacklow SC, Faryabi RB, Wherry EJ, et al. Trib1 regulates T cell differentiation during chronic infection by restraining the effector program. The Journal of Experimental Medicine. 217. PMID 32150623 DOI: 10.1084/jem.20190888  0.4
2019 Jarrett SM, Seegar TCM, Andrews M, Adelmant G, Marto JA, Aster JC, Blacklow SC. Extension of the Notch intracellular domain ankyrin repeat stack by NRARP promotes feedback inhibition of Notch signaling. Science Signaling. 12. PMID 31690634 DOI: 10.1126/scisignal.aay2369  0.52
2019 Petrovic J, Zhou Y, Fasolino M, Goldman N, Schwartz GW, Mumbach MR, Nguyen SC, Rome KS, Sela Y, Zapataro Z, Blacklow SC, Kruhlak MJ, Shi J, Aster JC, Joyce EF, et al. Oncogenic Notch Promotes Long-Range Regulatory Interactions within Hyperconnected 3D Cliques. Molecular Cell. PMID 30745086 DOI: 10.1016/j.molcel.2019.01.006  0.52
2018 Lovendahl KN, Blacklow SC, Gordon WR. The Molecular Mechanism of Notch Activation. Advances in Experimental Medicine and Biology. 1066: 47-58. PMID 30030821 DOI: 10.1007/978-3-319-89512-3_3  0.44
2017 Pajcini KV, Xu L, Shao L, Petrovic J, Palasiewicz K, Ohtani Y, Bailis W, Lee C, Wertheim GB, Mani R, Musuthamy N, Li Y, Meijerink JPP, Blacklow SC, Faryabi RB, et al. MAFB enhances oncogenic Notch signaling in T cell acute lymphoblastic leukemia. Science Signaling. 10. PMID 29138297 DOI: 10.1126/scisignal.aam6846  0.4
2017 Ryan RJH, Petrovic J, Rausch DM, Zhou Y, Lareau CA, Kluk MJ, Christie AL, Lee WY, Tarjan DR, Guo B, Donohue LKH, Gillespie SM, Nardi V, Hochberg EP, Blacklow SC, et al. A B Cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B Cell Lymphomas. Cell Reports. 21: 784-797. PMID 29045844 DOI: 10.1016/j.celrep.2017.09.066  0.52
2017 Choi SH, Severson E, Pear WS, Liu XS, Aster JC, Blacklow SC. The common oncogenomic program of NOTCH1 and NOTCH3 signaling in T-cell acute lymphoblastic leukemia. Plos One. 12: e0185762. PMID 29023469 DOI: 10.1371/journal.pone.0185762  0.52
2017 Sajed DP, Faquin WC, Carey C, Severson EA, H Afrogheh A, A Johnson C, Blacklow SC, Chau NG, Lin DT, Krane JF, Jo VY, Garcia JJ, Sholl LM, Aster JC. Diffuse Staining for Activated NOTCH1 Correlates With NOTCH1 Mutation Status and is Associated With Worse Outcome in Adenoid Cystic Carcinoma. The American Journal of Surgical Pathology. PMID 28914715 DOI: 10.1097/PAS.0000000000000945  0.52
2017 Severson E, Arnett KL, Wang H, Zang C, Taing L, Liu H, Pear WS, Shirley Liu X, Blacklow SC, Aster JC. Genome-wide identification and characterization of Notch transcription complex-binding sequence-paired sites in leukemia cells. Science Signaling. 10. PMID 28465412 DOI: 10.1126/scisignal.aag1598  0.52
2016 Durzynska I, Xu X, Adelmant G, Ficarro SB, Marto JA, Sliz P, Uljon S, Blacklow SC. STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1. Structure (London, England : 1993). PMID 28089446 DOI: 10.1016/j.str.2016.12.008  0.48
2016 Aster JC, Pear WS, Blacklow SC. The Varied Roles of Notch in Cancer. Annual Review of Pathology. PMID 27959635 DOI: 10.1146/annurev-pathol-052016-100127  0.52
2016 Guo B, McMillan BJ, Blacklow SC. Structure and function of the Mind bomb E3 ligase in the context of Notch signal transduction. Current Opinion in Structural Biology. 41: 38-45. PMID 27285058 DOI: 10.1016/  1
2016 Bernasconi-Elias P, Hu T, Jenkins D, Firestone B, Gans S, Kurth E, Capodieci P, Deplazes-Lauber J, Petropoulos K, Thiel P, Ponsel D, Hee Choi S, LeMotte P, London A, Goetcshkes M, ... ... Blacklow SC, et al. Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies. Oncogene. PMID 27157619 DOI: 10.1038/onc.2016.133  0.52
2016 Uljon S, Xu X, Durzynska I, Stein S, Adelmant G, Marto JA, Pear WS, Blacklow SC. Structural Basis for Substrate Selectivity of the E3 Ligase COP1. Structure (London, England : 1993). PMID 27041596 DOI: 10.1016/j.str.2016.03.002  1
2016 LaRochelle JR, Fodor M, Xu X, Durzynska I, Fan L, Stams T, Chan H, LaMarche MJ, Chopra R, Wang P, Fortin PD, Acker MG, Blacklow SC. Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2. Biochemistry. PMID 27030275 DOI: 10.1021/acs.biochem.5b01287  1
2016 Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, et al. Data publication with the structural biology data grid supports live analysis. Nature Communications. 7: 10882. PMID 26947396 DOI: 10.1038/ncomms10882  0.52
2015 Knoechel B, Bhatt A, Pan L, Pedamallu CS, Severson E, Gutierrez A, Dorfman DM, Kuo FC, Kluk M, Kung AL, Zweidler-McKay P, Meyerson M, Blacklow SC, DeAngelo DJ, Aster JC. Complete hematologic response of early T-cell progenitor acute lymphoblastic leukemia to the γ-secretase inhibitor BMS-906024: genetic and epigenetic findings in an outlier case. Cold Spring Harbor Molecular Case Studies. 1: a000539. PMID 27148573 DOI: 10.1101/mcs.a000539  0.52
2015 Xu X, Choi SH, Hu T, Tiyanont K, Habets R, Groot AJ, Vooijs M, Aster JC, Chopra R, Fryer C, Blacklow SC. Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region. Structure (London, England : 1993). 23: 1227-35. PMID 26051713 DOI: 10.1016/j.str.2015.05.001  1
2015 Gordon WR, Zimmerman B, He L, Miles LJ, Huang J, Tiyanont K, McArthur DG, Aster JC, Perrimon N, Loparo JJ, Blacklow SC. Mechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch. Developmental Cell. 33: 729-36. PMID 26051539 DOI: 10.1016/j.devcel.2015.05.004  1
2015 Habets RA, Groot AJ, Yahyanejad S, Tiyanont K, Blacklow SC, Vooijs M. Human NOTCH2 Is Resistant to Ligand-independent Activation by Metalloprotease Adam17. The Journal of Biological Chemistry. 290: 14705-16. PMID 25918160 DOI: 10.1074/jbc.M115.643676  1
2015 McMillan BJ, Schnute B, Ohlenhard N, Zimmerman B, Miles L, Beglova N, Klein T, Blacklow SC. A tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb E3 ligases. Molecular Cell. 57: 912-24. PMID 25747658 DOI: 10.1016/j.molcel.2015.01.019  1
2014 Yashiro-Ohtani Y, Wang H, Zang C, Arnett KL, Bailis W, Ho Y, Knoechel B, Lanauze C, Louis L, Forsyth KS, Chen S, Chung Y, Schug J, Blobel GA, Liebhaber SA, ... ... Blacklow SC, et al. Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia. Proceedings of the National Academy of Sciences of the United States of America. 111: E4946-53. PMID 25369933 DOI: 10.1073/pnas.1407079111  1
2014 McKeown MR, Shaw DL, Fu H, Liu S, Xu X, Marineau JJ, Huang Y, Zhang X, Buckley DL, Kadam A, Zhang Z, Blacklow SC, Qi J, Zhang W, Bradner JE. Biased multicomponent reactions to develop novel bromodomain inhibitors. Journal of Medicinal Chemistry. 57: 9019-27. PMID 25314271 DOI: 10.1021/jm501120z  1
2014 Arnett KL, Blacklow SC. Analyzing the nuclear complexes of Notch signaling by electrophoretic mobility shift assay. Methods in Molecular Biology (Clifton, N.J.). 1187: 231-45. PMID 25053494 DOI: 10.1007/978-1-4939-1139-4_18  1
2014 Wang H, Zang C, Taing L, Arnett KL, Wong YJ, Pear WS, Blacklow SC, Liu XS, Aster JC. NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers. Proceedings of the National Academy of Sciences of the United States of America. 111: 705-10. PMID 24374627 DOI: 10.1073/pnas.1315023111  1
2013 Blacklow SC. Refining a Jagged edge. Structure (London, England : 1993). 21: 2100-1. PMID 24315457 DOI: 10.1016/j.str.2013.11.001  1
2013 Wittinghofer A, Martin JB, Blacklow S. Proteins special issue of biopolymers. Biopolymers. 99: 807-8. PMID 23893350 DOI: 10.1002/bip.22353  1
2013 Andrawes MB, Xu X, Liu H, Ficarro SB, Marto JA, Aster JC, Blacklow SC. Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1. The Journal of Biological Chemistry. 288: 25477-89. PMID 23839946 DOI: 10.1074/jbc.M113.454850  1
2013 Tiyanont K, Wales TE, Siebel CW, Engen JR, Blacklow SC. Insights into Notch3 activation and inhibition mediated by antibodies directed against its negative regulatory region. Journal of Molecular Biology. 425: 3192-204. PMID 23747483 DOI: 10.1016/j.jmb.2013.05.025  1
2013 Roti G, Carlton A, Ross KN, Markstein M, Pajcini K, Su AH, Perrimon N, Pear WS, Kung AL, Blacklow SC, Aster JC, Stegmaier K. Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer. Cancer Cell. 23: 390-405. PMID 23434461 DOI: 10.1016/j.ccr.2013.01.015  1
2012 Aster JC, Blacklow SC. Targeting the Notch pathway: twists and turns on the road to rational therapeutics. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 30: 2418-20. PMID 22585704 DOI: 10.1200/JCO.2012.42.0992  1
2012 O'Donovan DJ, Stokes-Rees I, Nam Y, Blacklow SC, Schröder GF, Brunger AT, Sliz P. A grid-enabled web service for low-resolution crystal structure refinement. Acta Crystallographica. Section D, Biological Crystallography. 68: 261-7. PMID 22349228 DOI: 10.1107/S0907444912001163  1
2012 Choi SH, Wales TE, Nam Y, O'Donovan DJ, Sliz P, Engen JR, Blacklow SC. Conformational locking upon cooperative assembly of notch transcription complexes. Structure (London, England : 1993). 20: 340-9. PMID 22325781 DOI: 10.1016/j.str.2011.12.011  1
2011 Germar K, Dose M, Konstantinou T, Zhang J, Wang H, Lobry C, Arnett KL, Blacklow SC, Aifantis I, Aster JC, Gounari F. T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling. Proceedings of the National Academy of Sciences of the United States of America. 108: 20060-5. PMID 22109558 DOI: 10.1073/pnas.1110230108  1
2011 Aster JC, Bodnar N, Xu L, Karnell F, Milholland JM, Maillard I, Histen G, Nam Y, Blacklow SC, Pear WS. Notch ankyrin repeat domain variation influences leukemogenesis and Myc transactivation. Plos One. 6: e25645. PMID 22022427 DOI: 10.1371/journal.pone.0025645  1
2011 Wang NJ, Sanborn Z, Arnett KL, Bayston LJ, Liao W, Proby CM, Leigh IM, Collisson EA, Gordon PB, Jakkula L, Pennypacker S, Zou Y, Sharma M, North JP, Vemula SS, ... ... Blacklow SC, et al. Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma. Proceedings of the National Academy of Sciences of the United States of America. 108: 17761-6. PMID 22006338 DOI: 10.1073/pnas.1114669108  1
2011 Zhao B, Zou J, Wang H, Johannsen E, Peng CW, Quackenbush J, Mar JC, Morton CC, Freedman ML, Blacklow SC, Aster JC, Bernstein BE, Kieff E. Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth. Proceedings of the National Academy of Sciences of the United States of America. 108: 14902-7. PMID 21746931 DOI: 10.1073/pnas.1108892108  1
2011 Wang H, Zou J, Zhao B, Johannsen E, Ashworth T, Wong H, Pear WS, Schug J, Blacklow SC, Arnett KL, Bernstein BE, Kieff E, Aster JC. Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells. Proceedings of the National Academy of Sciences of the United States of America. 108: 14908-13. PMID 21737748 DOI: 10.1073/pnas.1109023108  1
2011 Tiyanont K, Wales TE, Aste-Amezaga M, Aster JC, Engen JR, Blacklow SC. Evidence for increased exposure of the Notch1 metalloprotease cleavage site upon conversion to an activated conformation. Structure (London, England : 1993). 19: 546-54. PMID 21481777 DOI: 10.1016/j.str.2011.01.016  1
2011 Calderwood MA, Lee S, Holthaus AM, Blacklow SC, Kieff E, Johannsen E. Epstein-Barr virus nuclear protein 3C binds to the N-terminal (NTD) and beta trefoil domains (BTD) of RBP/CSL; only the NTD interaction is essential for lymphoblastoid cell growth. Virology. 414: 19-25. PMID 21440926 DOI: 10.1016/j.virol.2011.02.018  1
2011 Aster JC, Blacklow SC, Pear WS. Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies. The Journal of Pathology. 223: 262-73. PMID 20967796 DOI: 10.1002/path.2789  1
2010 Del Bianco C, Vedenko A, Choi SH, Berger MF, Shokri L, Bulyk ML, Blacklow SC. Notch and MAML-1 complexation do not detectably alter the DNA binding specificity of the transcription factor CSL. Plos One. 5: e15034. PMID 21124806 DOI: 10.1371/journal.pone.0015034  1
2010 Arnett KL, Hass M, McArthur DG, Ilagan MX, Aster JC, Kopan R, Blacklow SC. Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes. Nature Structural & Molecular Biology. 17: 1312-7. PMID 20972443 DOI: 10.1038/nsmb.1938  1
2010 Liu H, Chi AW, Arnett KL, Chiang MY, Xu L, Shestova O, Wang H, Li YM, Bhandoola A, Aster JC, Blacklow SC, Pear WS. Notch dimerization is required for leukemogenesis and T-cell development. Genes & Development. 24: 2395-407. PMID 20935071 DOI: 10.1101/gad.1975210  1
2010 Ashworth TD, Pear WS, Chiang MY, Blacklow SC, Mastio J, Xu L, Kelliher M, Kastner P, Chan S, Aster JC. Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1. Blood. 116: 5455-64. PMID 20852131 DOI: 10.1182/blood-2010-05-286328  1
2010 Kovall RA, Blacklow SC. Mechanistic insights into Notch receptor signaling from structural and biochemical studies. Current Topics in Developmental Biology. 92: 31-71. PMID 20816392 DOI: 10.1016/S0070-2153(10)92002-4  1
2010 Keeshan K, Bailis W, Dedhia PH, Vega ME, Shestova O, Xu L, Toscano K, Uljon SN, Blacklow SC, Pear WS. Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding. Blood. 116: 4948-57. PMID 20805362 DOI: 10.1182/blood-2009-10-247361  1
2010 Dedhia PH, Keeshan K, Uljon S, Xu L, Vega ME, Shestova O, Zaks-Zilberman M, Romany C, Blacklow SC, Pear WS. Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia. Blood. 116: 1321-8. PMID 20410507 DOI: 10.1182/blood-2009-07-229450  1
2010 Aste-Amézaga M, Zhang N, Lineberger JE, Arnold BA, Toner TJ, Gu M, Huang L, Vitelli S, Vo KT, Haytko P, Zhao JZ, Baleydier F, L'Heureux S, Wang H, Gordon WR, ... ... Blacklow SC, et al. Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors. Plos One. 5: e9094. PMID 20161710 DOI: 10.1371/journal.pone.0009094  1
2009 Moellering RE, Cornejo M, Davis TN, Del Bianco C, Aster JC, Blacklow SC, Kung AL, Gilliland DG, Verdine GL, Bradner JE. Direct inhibition of the NOTCH transcription factor complex. Nature. 462: 182-8. PMID 19907488 DOI: 10.1038/nature08543  1
2009 Gordon WR, Vardar-Ulu D, L'Heureux S, Ashworth T, Malecki MJ, Sanchez-Irizarry C, McArthur DG, Histen G, Mitchell JL, Aster JC, Blacklow SC. Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2. Plos One. 4: e6613. PMID 19701457 DOI: 10.1371/journal.pone.0006613  1
2009 Yashiro-Ohtani Y, He Y, Ohtani T, Jones ME, Shestova O, Xu L, Fang TC, Chiang MY, Intlekofer AM, Blacklow SC, Zhuang Y, Pear WS. Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A. Genes & Development. 23: 1665-76. PMID 19605688 DOI: 10.1101/gad.1793709  1
2009 Gordon WR, Roy M, Vardar-Ulu D, Garfinkel M, Mansour MR, Aster JC, Blacklow SC. Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL. Blood. 113: 4381-90. PMID 19075186 DOI: 10.1182/blood-2008-08-174748  1
2008 Gordon WR, Arnett KL, Blacklow SC. The molecular logic of Notch signaling--a structural and biochemical perspective. Journal of Cell Science. 121: 3109-19. PMID 18799787 DOI: 10.1242/jcs.035683  1
2008 Li K, Li Y, Wu W, Gordon WR, Chang DW, Lu M, Scoggin S, Fu T, Vien L, Histen G, Zheng J, Martin-Hollister R, Duensing T, Singh S, Blacklow SC, et al. Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3. The Journal of Biological Chemistry. 283: 8046-54. PMID 18182388 DOI: 10.1074/jbc.M800170200  1
2008 Estrada K, Fisher C, Blacklow SC. Unfolding of the RAP-D3 helical bundle facilitates dissociation of RAP-receptor complexes. Biochemistry. 47: 1532-9. PMID 18177055 DOI: 10.1021/bi702076y  1
2008 Del Bianco C, Aster JC, Blacklow SC. Mutational and energetic studies of Notch 1 transcription complexes. Journal of Molecular Biology. 376: 131-40. PMID 18155729 DOI: 10.1016/j.jmb.2007.11.061  1
2008 Aster JC, Pear WS, Blacklow SC. Notch signaling in leukemia. Annual Review of Pathology. 3: 587-613. PMID 18039126 DOI: 10.1146/annurev.pathmechdis.3.121806.154300  1
2007 Blacklow SC. Versatility in ligand recognition by LDL receptor family proteins: advances and frontiers. Current Opinion in Structural Biology. 17: 419-26. PMID 17870468 DOI: 10.1016/  1
2007 Fang TC, Yashiro-Ohtani Y, Del Bianco C, Knoblock DM, Blacklow SC, Pear WS. Notch directly regulates Gata3 expression during T helper 2 cell differentiation. Immunity. 27: 100-10. PMID 17658278 DOI: 10.1016/j.immuni.2007.04.018  1
2007 Koduri V, Blacklow SC. Requirement for natively unstructured regions of mesoderm development candidate 2 in promoting low-density lipoprotein receptor-related protein 6 maturation. Biochemistry. 46: 6570-7. PMID 17488095 DOI: 10.1021/bi700049g  1
2007 Gordon WR, Vardar-Ulu D, Histen G, Sanchez-Irizarry C, Aster JC, Blacklow SC. Structural basis for autoinhibition of Notch. Nature Structural & Molecular Biology. 14: 295-300. PMID 17401372 DOI: 10.1038/nsmb1227  1
2007 Nam Y, Sliz P, Pear WS, Aster JC, Blacklow SC. Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription. Proceedings of the National Academy of Sciences of the United States of America. 104: 2103-8. PMID 17284587 DOI: 10.1073/pnas.0611092104  1
2006 Chiang MY, Xu ML, Histen G, Shestova O, Roy M, Nam Y, Blacklow SC, Sacks DB, Pear WS, Aster JC. Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1. Molecular and Cellular Biology. 26: 6261-71. PMID 16880534 DOI: 10.1128/MCB.02478-05  1
2006 Weng AP, Millholland JM, Yashiro-Ohtani Y, Arcangeli ML, Lau A, Wai C, Del Bianco C, Rodriguez CG, Sai H, Tobias J, Li Y, Wolfe MS, Shachaf C, Felsher D, Blacklow SC, et al. c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. Genes & Development. 20: 2096-109. PMID 16847353 DOI: 10.1101/gad.1450406  1
2006 Malecki MJ, Sanchez-Irizarry C, Mitchell JL, Histen G, Xu ML, Aster JC, Blacklow SC. Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes. Molecular and Cellular Biology. 26: 4642-51. PMID 16738328 DOI: 10.1128/MCB.01655-05  1
2006 Fisher C, Beglova N, Blacklow SC. Structure of an LDLR-RAP complex reveals a general mode for ligand recognition by lipoprotein receptors. Molecular Cell. 22: 277-83. PMID 16630895 DOI: 10.1016/j.molcel.2006.02.021  1
2006 Nam Y, Sliz P, Song L, Aster JC, Blacklow SC. Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell. 124: 973-83. PMID 16530044 DOI: 10.1016/j.cell.2005.12.037  1
2005 Blacklow SC. A new niche for Notch on Deltex? Structure (London, England : 1993). 13: 1579-80. PMID 16271878 DOI: 10.1016/j.str.2005.10.001  1
2005 Tan Z, Blacklow SC, Cornish VW, Forster AC. De novo genetic codes and pure translation display. Methods (San Diego, Calif.). 36: 279-90. PMID 16076454 DOI: 10.1016/j.ymeth.2005.04.011  1
2005 Jeon H, Blacklow SC. Structure and physiologic function of the low-density lipoprotein receptor. Annual Review of Biochemistry. 74: 535-62. PMID 15952897 DOI: 10.1146/annurev.biochem.74.082803.133354  1
2005 Beglova N, Blacklow SC. The LDL receptor: how acid pulls the trigger. Trends in Biochemical Sciences. 30: 309-17. PMID 15950875 DOI: 10.1016/j.tibs.2005.03.007  1
2005 Abdul-Aziz D, Fisher C, Beglova N, Blacklow SC. Folding and binding integrity of variants of a prototype ligand-binding module from the LDL receptor possessing multiple alanine substitutions. Biochemistry. 44: 5075-85. PMID 15794645 DOI: 10.1021/bi047575j  1
2005 Stolt PC, Chen Y, Liu P, Bock HH, Blacklow SC, Herz J. Phosphoinositide binding by the disabled-1 PTB domain is necessary for membrane localization and Reelin signal transduction. The Journal of Biological Chemistry. 280: 9671-7. PMID 15632144 DOI: 10.1074/jbc.M413356200  1
2004 Beglova N, Jeon H, Fisher C, Blacklow SC. Cooperation between fixed and low pH-inducible interfaces controls lipoprotein release by the LDL receptor. Molecular Cell. 16: 281-92. PMID 15494314 DOI: 10.1016/j.molcel.2004.09.038  1
2004 Beglova N, Jeon H, Fisher C, Blacklow SC. Structural features of the low-density lipoprotein receptor facilitating ligand binding and release. Biochemical Society Transactions. 32: 721-3. PMID 15493997 DOI: 10.1042/BST0320721  1
2004 Sanchez-Irizarry C, Carpenter AC, Weng AP, Pear WS, Aster JC, Blacklow SC. Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats. Molecular and Cellular Biology. 24: 9265-73. PMID 15485896 DOI: 10.1128/MCB.24.21.9265-9273.2004  1
2004 Weng AP, Ferrando AA, Lee W, Morris JP, Silverman LB, Sanchez-Irizarry C, Blacklow SC, Look AT, Aster JC. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science (New York, N.Y.). 306: 269-71. PMID 15472075 DOI: 10.1126/science.1102160  1
2004 Tan Z, Forster AC, Blacklow SC, Cornish VW. Amino acid backbone specificity of the Escherichia coli translation machinery. Journal of the American Chemical Society. 126: 12752-3. PMID 15469251 DOI: 10.1021/ja0472174  1
2004 Forster AC, Cornish VW, Blacklow SC. Pure translation display. Analytical Biochemistry. 333: 358-64. PMID 15450813 DOI: 10.1016/j.ab.2004.06.028  1
2004 Stolt PC, Vardar D, Blacklow SC. The dual-function disabled-1 PTB domain exhibits site independence in binding phosphoinositide and peptide ligands. Biochemistry. 43: 10979-87. PMID 15323557 DOI: 10.1021/bi049092l  1
2004 Blacklow SC. Catching the common cold. Nature Structural & Molecular Biology. 11: 388-90. PMID 15114337 DOI: 10.1038/nsmb0504-388  1
2004 Boswell EJ, Jeon H, Blacklow SC, Downing AK. Global defects in the expression and function of the low density lipoprotein receptor (LDLR) associated with two familial hypercholesterolemia mutations resulting in misfolding of the LDLR epidermal growth factor-AB pair. The Journal of Biological Chemistry. 279: 30611-21. PMID 15100232 DOI: 10.1074/jbc.M401412200  1
2004 Fisher C, Abdul-Aziz D, Blacklow SC. A two-module region of the low-density lipoprotein receptor sufficient for formation of complexes with apolipoprotein E ligands. Biochemistry. 43: 1037-44. PMID 14744149 DOI: 10.1021/bi035529y  1
2004 Smith JG, Mothes W, Blacklow SC, Cunningham JM. The mature avian leukosis virus subgroup A envelope glycoprotein is metastable, and refolding induced by the synergistic effects of receptor binding and low pH is coupled to infection. Journal of Virology. 78: 1403-10. PMID 14722295 DOI: 10.1128/JVI.78.3.1403-1410.2004  1
2003 Kim PW, Sun ZY, Blacklow SC, Wagner G, Eck MJ. A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8. Science (New York, N.Y.). 301: 1725-8. PMID 14500983 DOI: 10.1126/science.1085643  1
2003 Vardar D, North CL, Sanchez-Irizarry C, Aster JC, Blacklow SC. Nuclear magnetic resonance structure of a prototype Lin12-Notch repeat module from human Notch1. Biochemistry. 42: 7061-7. PMID 12795601 DOI: 10.1021/bi034156y  1
2003 Forster AC, Tan Z, Nalam MN, Lin H, Qu H, Cornish VW, Blacklow SC. Programming peptidomimetic syntheses by translating genetic codes designed de novo. Proceedings of the National Academy of Sciences of the United States of America. 100: 6353-7. PMID 12754376 DOI: 10.1073/pnas.1132122100  1
2003 Stolt PC, Jeon H, Song HK, Herz J, Eck MJ, Blacklow SC. Origins of peptide selectivity and phosphoinositide binding revealed by structures of disabled-1 PTB domain complexes. Structure (London, England : 1993). 11: 569-79. PMID 12737822 DOI: 10.1016/S0969-2126(03)00068-6  1
2003 Nam Y, Weng AP, Aster JC, Blacklow SC. Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex. The Journal of Biological Chemistry. 278: 21232-9. PMID 12644465 DOI: 10.1074/jbc.M301567200  1
2003 Jeon H, Blacklow SC. An intramolecular spin of the LDL receptor beta propeller. Structure (London, England : 1993). 11: 133-6. PMID 12575931 DOI: 10.1016/S0969-2126(03)00010-8  1
2003 Weng AP, Nam Y, Wolfe MS, Pear WS, Griffin JD, Blacklow SC, Aster JC. Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling. Molecular and Cellular Biology. 23: 655-64. PMID 12509463 DOI: 10.1128/MCB.23.2.655-664.2003  1
2002 Nam Y, Aster JC, Blacklow SC. Notch signaling as a therapeutic target. Current Opinion in Chemical Biology. 6: 501-9. PMID 12133727 DOI: 10.1016/S1367-5931(02)00346-0  1
2002 Beglova N, Blacklow SC, Takagi J, Springer TA. Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation. Nature Structural Biology. 9: 282-7. PMID 11896403 DOI: 10.1038/nsb779  1
2002 Stone JR, Maki JL, Blacklow SC, Collins T. The SCAN domain of ZNF174 is a dimer. The Journal of Biological Chemistry. 277: 5448-52. PMID 11741982 DOI: 10.1074/jbc.M109815200  1
2001 Koduri V, Blacklow SC. Folding determinants of LDL receptor type A modules. Biochemistry. 40: 12801-7. PMID 11669616 DOI: 10.1021/bi011344k  1
2001 Takagi J, Beglova N, Yalamanchili P, Blacklow SC, Springer TA. Definition of EGF-like, closely interacting modules that bear activation epitopes in integrin beta subunits. Proceedings of the National Academy of Sciences of the United States of America. 98: 11175-80. PMID 11572973 DOI: 10.1073/pnas.201420198  1
2001 Forster AC, Weissbach H, Blacklow SC. A simplified reconstitution of mRNA-directed peptide synthesis: activity of the epsilon enhancer and an unnatural amino acid. Analytical Biochemistry. 297: 60-70. PMID 11567528 DOI: 10.1006/abio.2001.5329  1
2001 Jeon H, Meng W, Takagi J, Eck MJ, Springer TA, Blacklow SC. Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair. Nature Structural Biology. 8: 499-504. PMID 11373616 DOI: 10.1038/88556  1
2001 Adkins HB, Blacklow SC, Young JA. Two functionally distinct forms of a retroviral receptor explain the nonreciprocal receptor interference among subgroups B, D, and E avian leukosis viruses. Journal of Virology. 75: 3520-6. PMID 11264341 DOI: 10.1128/JVI.75.8.3520-3526.2001  1
2001 Beglova N, North CL, Blacklow SC. Backbone dynamics of a module pair from the ligand-binding domain of the LDL receptor. Biochemistry. 40: 2808-15. PMID 11258891 DOI: 10.1021/bi0027276  1
2000 Wu L, Aster JC, Blacklow SC, Lake R, Artavanis-Tsakonas S, Griffin JD. MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors. Nature Genetics. 26: 484-9. PMID 11101851 DOI: 10.1038/82644  1
2000 North CL, Blacklow SC. Evidence that familial hypercholesterolemia mutations of the LDL receptor cause limited local misfolding in an LDL-A module pair. Biochemistry. 39: 13127-35. PMID 11052664 DOI: 10.1021/bi0015156  1
2000 North CL, Blacklow SC. Solution structure of the sixth LDL-A module of the LDL receptor. Biochemistry. 39: 2564-71. PMID 10704205 DOI: 10.1021/bi992087a  1
2000 Rand MD, Grimm LM, Artavanis-Tsakonas S, Patriub V, Blacklow SC, Sklar J, Aster JC. Calcium depletion dissociates and activates heterodimeric notch receptors. Molecular and Cellular Biology. 20: 1825-35. PMID 10669757 DOI: 10.1128/MCB.20.5.1825-1835.2000  1
1999 Williams AJ, Blacklow SC, Collins T. The zinc finger-associated SCAN box is a conserved oligomerization domain. Molecular and Cellular Biology. 19: 8526-35. PMID 10567577  1
1999 Aster JC, Simms WB, Zavala-Ruiz Z, Patriub V, North CL, Blacklow SC. The folding and structural integrity of the first LIN-12 module of human Notch1 are calcium-dependent. Biochemistry. 38: 4736-42. PMID 10200161 DOI: 10.1021/bi982713o  1
1999 Zhang Z, Komives EA, Sugio S, Blacklow SC, Narayana N, Xuong NH, Stock AM, Petsko GA, Ringe D. The role of water in the catalytic efficiency of triosephosphate isomerase. Biochemistry. 38: 4389-97. PMID 10194358 DOI: 10.1021/bi9826759  1
1999 North CL, Blacklow SC. Structural independence of ligand-binding modules five and six of the LDL receptor. Biochemistry. 38: 3926-35. PMID 10194304 DOI: 10.1021/bi9821622  1
1997 Fass D, Blacklow S, Kim PS, Berger JM. Molecular basis of familial hypercholesterolaemia from structure of LDL receptor module. Nature. 388: 691-3. PMID 9262405 DOI: 10.1038/41798  1
1996 Blacklow SC, Kim PS. Protein folding and calcium binding defects arising from familial hypercholesterolemia mutations of the LDL receptor. Nature Structural Biology. 3: 758-62. PMID 8784348 DOI: 10.1038/nsb0996-758  1
1996 Appignani BA, Bhadelia RA, Blacklow SC, Wang AK, Roland SF, Freeman RB. Neuroimaging findings in patients on immunosuppressive therapy: experience with tacrolimus toxicity. Ajr. American Journal of Roentgenology. 166: 683-8. PMID 8623651 DOI: 10.2214/ajr.166.3.8623651  1
1995 Lu M, Blacklow SC, Kim PS. A trimeric structural domain of the HIV-1 transmembrane glycoprotein. Nature Structural Biology. 2: 1075-82. PMID 8846219  1
1995 Blacklow SC, Lu M, Kim PS. A trimeric subdomain of the simian immunodeficiency virus envelope glycoprotein. Biochemistry. 34: 14955-62. PMID 7578108  1
1993 Goldhaber SZ, Simons GR, Elliott CG, Haire WD, Toltzis R, Blacklow SC, Doolittle MH, Weinberg DS. Quantitative plasma D-dimer levels among patients undergoing pulmonary angiography for suspected pulmonary embolism. Jama. 270: 2819-22. PMID 8133620 DOI: 10.1001/jama.1993.03510230057035  1
1991 Blacklow SC, Liu KD, Knowles JR. Stepwise improvements in catalytic effectiveness: independence and interdependence in combinations of point mutations of a sluggish triosephosphate isomerase. Biochemistry. 30: 8470-6. PMID 1883832  1
1990 Blacklow SC, Knowles JR. How can a catalytic lesion be offset? The energetics of two pseudorevertant triosephosphate isomerases. Biochemistry. 29: 4099-108. PMID 2361134  1
1990 Hermes JD, Blacklow SC, Knowles JR. Searching sequence space by definably random mutagenesis: improving the catalytic potency of an enzyme. Proceedings of the National Academy of Sciences of the United States of America. 87: 696-700. PMID 1967829  1
1989 Hermes JD, Parekh SM, Blacklow SC, Köster H, Knowles JR. A reliable method for random mutagenesis: the generation of mutant libraries using spiked oligodeoxyribonucleotide primers. Gene. 84: 143-51. PMID 2691332 DOI: 10.1016/0378-1119(89)90148-0  1
1988 Blacklow SC, Raines RT, Lim WA, Zamore PD, Knowles JR. Triosephosphate isomerase catalysis is diffusion controlled. Appendix: Analysis of triose phosphate equilibria in aqueous solution by 31P NMR. Biochemistry. 27: 1158-67. PMID 3365378 DOI: 10.1021/bi00404a013  1
1987 Hermes JD, Blacklow SC, Knowles JR. The development of enzyme catalytic efficiency: an experimental approach. Cold Spring Harbor Symposia On Quantitative Biology. 52: 597-602. PMID 3454280  1
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