David A. Williams, MD - Publications

Boston Children's Hospital, Harvard Boston Children's Hospital, Harvard 

248 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Ackermann M, Mucci A, McCabe A, Frei S, Wright K, Snapper SB, Lachmann N, Williams DA, Brendel C. Restored macrophage function ameliorates disease pathophysiology in a mouse model for IL10 receptor deficient very early onset inflammatory bowel disease. Journal of Crohn's & Colitis. PMID 33596307 DOI: 10.1093/ecco-jcc/jjab031  1
2020 Esrick EB, Lehmann LE, Biffi A, Achebe M, Brendel C, Ciuculescu MF, Daley H, MacKinnon B, Morris E, Federico A, Abriss D, Boardman K, Khelladi R, Shaw K, Negre H, ... ... Williams DA, et al. Post-Transcriptional Genetic Silencing of to Treat Sickle Cell Disease. The New England Journal of Medicine. PMID 33283990 DOI: 10.1056/NEJMoa2029392  1
2020 Verboon JM, Mahmut D, Kim AR, Nakamura M, Abdulhay NJ, Nandakumar SK, Gupta N, Akie TE, Geddis AE, Manes B, Kapp ME, Hofmann I, Gabriel SB, Klein DE, Williams DA, et al. Infantile Myelofibrosis and Myeloproliferation with CDC42 Dysfunction. Journal of Clinical Immunology. PMID 32303876 DOI: 10.1007/S10875-020-00778-7  1
2020 Brendel C, Negre O, Rothe M, Guda S, Parsons G, Harris C, McGuinness M, Abriss D, Tsytsykova A, Klatt D, Bentler M, Pellin D, Christiansen L, Schambach A, Manis J, ... ... Williams DA, et al. Preclinical Evaluation of a Novel Lentiviral Vector Driving Lineage-Specific BCL11A Knockdown for Sickle Cell Gene Therapy. Molecular Therapy. Methods & Clinical Development. 17: 589-600. PMID 32300607 DOI: 10.1016/J.Omtm.2020.03.015  1
2020 Brendel C, Williams DA. Current and future gene therapies for hemoglobinopathies. Current Opinion in Hematology. PMID 32205585 DOI: 10.1097/Moh.0000000000000581  1
2020 Kohn DB, Booth C, Kang EM, Pai SY, Shaw KL, Santilli G, Armant M, Buckland KF, Choi U, De Ravin SS, Dorsey MJ, Kuo CY, Leon-Rico D, Rivat C, Izotova N, ... ... Williams DA, et al. Lentiviral gene therapy for X-linked chronic granulomatous disease. Nature Medicine. PMID 31988463 DOI: 10.1038/S41591-019-0735-5  1
2019 Curran KJ, Margossian S, Kernan NA, Silverman LB, Williams DA, Shukla NN, Kobos R, Forlenza C, Steinherz P, Prockop S, Boulad F, Spitzer B, Cancio MI, Boelens JJ, Kung AL, et al. Toxicity and Response following CD19-specific CAR T cells in pediatric/young adult relapsed/refractory B-ALL. Blood. PMID 31650176 DOI: 10.1182/Blood.2019001641  0.96
2019 Wu Y, Zeng J, Roscoe BP, Liu P, Yao Q, Lazzarotto CR, Clement K, Cole MA, Luk K, Baricordi C, Shen AH, Ren C, Esrick EB, Manis JP, Dorfman DM, ... Williams DA, et al. Highly efficient therapeutic gene editing of human hematopoietic stem cells. Nature Medicine. PMID 30911135 DOI: 10.1038/S41591-019-0401-Y  1
2019 Wenske B, Marischen L, Welzenbach J, Heimbach A, Hoffmann P, Corbacioglu S, Williams DA, Troeger A. Investigation of Cell-Contact Dependent Alterations in Immune Synapse Formation between T Cells and BCP-ALL Cells Blood. 134: 2754-2754. DOI: 10.1182/Blood-2019-128835  1
2019 Labrosse R, Chu J, Armant M, Spek Jvd, Miggelbrink A, Fong J, Everett JK, Raymond H, Kessler L, Dansereau C, Mackinnon B, Koo S, Morris E, London WB, Ozen A, ... ... Williams DA, et al. Outcome of Hematopoietic Stem Cell Gene Therapy for Wiskott-Aldrich Syndrome Blood. 134: 4629-4629. DOI: 10.1182/Blood-2019-126161  1
2018 Esrick EB, Manis JP, Daley H, Baricordi C, Trébéden-Negre H, Pierciey FJ, Armant M, Nikiforow S, Heeney MM, London WB, Biasco L, Asmal M, Williams DA, Biffi A. Successful hematopoietic stem cell mobilization and apheresis collection using plerixafor alone in sickle cell patients. Blood Advances. 2: 2505-2512. PMID 30282642 DOI: 10.1182/Bloodadvances.2018016725  1
2018 Park HH, Triboulet R, Bentler M, Guda S, Du P, Xu H, Gregory RI, Brendel C, Williams DA. DROSHA Knockout Leads to Enhancement of Viral Titers for Vectors Encoding miRNA-Adapted shRNAs. Molecular Therapy. Nucleic Acids. 12: 591-599. PMID 30195795 DOI: 10.1016/J.Omtn.2018.07.002  1
2018 D'Cruz AA, Speir M, Bliss-Moreau M, Dietrich S, Wang S, Chen AA, Gavillet M, Al-Obeidi A, Lawlor KE, Vince JE, Kelliher MA, Hakem R, Pasparakis M, Williams DA, Ericsson M, et al. The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils. Science Signaling. 11. PMID 30181240 DOI: 10.1126/Scisignal.Aao1716  1
2018 Zeng J, Bauer DE, Wu Y, Roscoe BP, Liu P, Yao Q, Lazzarrotto C, Clement MK, Cole MA, Luk K, Baricordi C, Esrick EB, Manis JP, Dorfma D, Williams DA, et al. Highly Efficient Therapeutic Gene Editing of BCL11A enhancer in Human Hematopoietic Stem Cells from ß-Hemoglobinopathy Patients for Fetal Hemoglobin Induction Blood. 132: 3482-3482. DOI: 10.1182/Blood-2018-99-119365  1
2018 McCabe A, Brendel C, Frei S, Klatt D, Bentler M, Snapper S, Williams DA. Interleukin-10 Signaling in Hematopoietic Stem and Progenitor Cells Maintains Stem Cell Function and Regulates Inflammation-Induced Myeloid Cell Output Blood. 132: 2407-2407. DOI: 10.1182/Blood-2018-99-116168  1
2018 Horiguchi H, Ciuculescu MF, Troeger A, Xu H, Brendel C, Williams DA. Deletion of Murine Rhoh induces More Aggressive Diffuse Large B Cell Lymphoma (DLBCL) Via Interaction with Kaiso and Regulation of BCL-6 Expression Blood. 132: 1574-1574. DOI: 10.1182/Blood-2018-99-115238  1
2017 De Vita S, Li Y, Harris CE, McGuinness MK, Ma C, Williams DA. The gp130 Cytokine IL-11 Regulates Engraftment of Vav1-/- Hematopoietic Stem and Progenitor Cells in Lethally Irradiated Recipients. Stem Cells (Dayton, Ohio). PMID 29235178 DOI: 10.1002/Stem.2760  1
2017 De Vita S, Li Y, Harris CE, McGuinness MK, Ma C, Williams DA. The gp130 Cytokine IL-11 Regulates Engraftment of Vav1-/- Hematopoietic Stem and Progenitor Cells in Lethally Irradiated Recipients. Stem Cells (Dayton, Ohio). PMID 29235178 DOI: 10.1002/stem.2760  1
2017 Gavillet M, Martinod K, Renella R, Wagner DD, Williams DA. A key role for Rac and Pak signaling in Neutrophil Extracellular Traps (NETs) formation defines a new potential therapeutic target. American Journal of Hematology. PMID 29124783 DOI: 10.1002/Ajh.24970  1
2017 Gavillet M, Martinod K, Renella R, Wagner DD, Williams DA. A key role for Rac and Pak signaling in Neutrophil Extracellular Traps (NETs) formation defines a new potential therapeutic target. American Journal of Hematology. PMID 29124783 DOI: 10.1002/Ajh.24970  1
2017 Eichler F, Duncan C, Musolino PL, Orchard PJ, De Oliveira S, Thrasher AJ, Armant M, Dansereau C, Lund TC, Miller WP, Raymond GV, Sankar R, Shah AJ, Sevin C, Gaspar HB, ... ... Williams DA, et al. Hematopoietic Stem-Cell Gene Therapy for Cerebral Adrenoleukodystrophy. The New England Journal of Medicine. PMID 28976817 DOI: 10.1056/Nejmoa1700554  1
2017 Alonso-Ferrero ME, van Til NP, Bartolovic K, Mata MF, Wagemaker G, Moulding D, Williams DA, Kinnon C, Waddington SN, Milsom MD, Howe SJ. Enhancement of mouse hematopoietic stem/progenitor cell function via transient gene delivery using integration-deficient lentiviral vectors. Experimental Hematology. PMID 28911908 DOI: 10.1016/J.Exphem.2017.09.003  1
2017 Williams DA, Orkin SH. The 2017 ASPHO distinguished career award goes to Holcombe E. Grier, MD. Pediatric Blood & Cancer. 64. PMID 28371236 DOI: 10.1002/Pbc.26483  1
2017 Thrasher AJ, Williams DA. Evolving Gene Therapy in Primary Immunodeficiency. Molecular Therapy : the Journal of the American Society of Gene Therapy. 25: 1132-1141. PMID 28366768 DOI: 10.1016/J.Ymthe.2017.03.018  1
2016 Brendel C, Guda S, Renella R, Bauer DE, Canver MC, Kim YJ, Heeney MM, Klatt D, Fogel J, Milsom MD, Orkin SH, Gregory RI, Williams DA. Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype. The Journal of Clinical Investigation. 126: 3868-3878. PMID 27599293 DOI: 10.1172/Jci87885  1
2016 Mino A, Troeger A, Brendel C, Cantor A, Harris C, Ciuculescu MF, Williams DA. RhoH participates in a multi-protein complex with the zinc finger protein kaiso that regulates both cytoskeletal structures and chemokine-induced T cells. Small Gtpases. 1-14. PMID 27574848 DOI: 10.1080/21541248.2016.1220780  1
2016 Townsend EC, Murakami MA, Christodoulou A, Christie AL, Köster J, DeSouza TA, Morgan EA, Kallgren SP, Liu H, Wu SC, Plana O, Montero J, Stevenson KE, Rao P, Vadhi R, ... ... Williams DA, et al. The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. Cancer Cell. 30: 183. PMID 27479034 DOI: 10.1016/J.Ccell.2016.06.008  1
2016 Altrock PM, Brendel C, Renella R, Orkin SH, Williams DA, Michor F. Mathematical modeling of erythrocyte chimerism informs genetic intervention strategies for sickle cell disease. American Journal of Hematology. 91: 931-7. PMID 27299299 DOI: 10.1002/Ajh.24449  1
2016 Labenski V, Suerth JD, Barczak E, Heckl D, Levy C, Bernadin O, Charpentier E, Williams DA, Fehse B, Verhoeyen E, Schambach A. Alpharetroviral self-inactivating vectors produced by a superinfection-resistant stable packaging cell line allow genetic modification of primary human T lymphocytes. Biomaterials. 97: 97-109. PMID 27162078 DOI: 10.1016/J.Biomaterials.2016.04.019  1
2016 Townsend EC, Murakami MA, Christodoulou A, Christie AL, Köster J, DeSouza TA, Morgan EA, Kallgren SP, Liu H, Wu SC, Plana O, Montero J, Stevenson KE, Rao P, Vadhi R, ... ... Williams DA, et al. The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. Cancer Cell. 29: 574-86. PMID 27070704 DOI: 10.1016/J.Ccell.2016.03.008  1
2016 Reddy PN, Radu M, Xu K, Wood J, Harris CE, Chernoff J, Williams DA. p21-activated kinase 2 regulates HSPC cytoskeleton, migration, and homing via CDC42 activation and interaction with β-Pix. Blood. 127: 1967-75. PMID 26932803 DOI: 10.1182/Blood-2016-01-693572  1
2016 Williams DA, Gavillet M. Response to correspondence: Flow cytometric quantification of neutrophil extracellular traps: Limitations of the methodological approach by Ciepiela et al. American Journal of Hematology. 91: E10. PMID 26749259 DOI: 10.1002/Ajh.24292  1
2015 Gavillet M, Martinod K, Renella R, Harris C, Shapiro NI, Wagner DD, Williams DA. Flow cytometric assay for direct quantification of neutrophil extracellular traps in blood samples. American Journal of Hematology. 90: 1155-8. PMID 26347989 DOI: 10.1002/Ajh.24185  1
2015 Guda S, Brendel C, Renella R, Du P, Bauer DE, Canver MC, Grenier JK, Grimson AW, Kamran SC, Thornton J, de Boer H, Root DE, Milsom MD, Orkin SH, Gregory RI, ... Williams DA, et al. miRNA-embedded shRNAs for Lineage-specific BCL11A Knockdown and Hemoglobin F Induction. Molecular Therapy : the Journal of the American Society of Gene Therapy. 23: 1465-74. PMID 26080908 DOI: 10.1038/Mt.2015.113  1
2015 Ciuculescu MF, Park SY, Canty K, Mathieu R, Silberstein LE, Williams DA. Perivascular deletion of murine Rac reverses the ratio of marrow arterioles and sinusoid vessels and alters hematopoiesis in vivo. Blood. 125: 3105-13. PMID 25824687 DOI: 10.1182/Blood-2014-10-604892  1
2015 Walter D, Lier A, Geiselhart A, Thalheimer FB, Huntscha S, Sobotta MC, Moehrle B, Brocks D, Bayindir I, Kaschutnig P, Muedder K, Klein C, Jauch A, Schroeder T, Geiger H, ... ... Williams DA, et al. Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells. Nature. 520: 549-52. PMID 25707806 DOI: 10.1038/Nature14131  1
2015 Zhang MY, Churpek JE, Keel SB, Walsh T, Lee MK, Loeb KR, Gulsuner S, Pritchard CC, Sanchez-Bonilla M, Delrow JJ, Basom RS, Forouhar M, Gyurkocza B, Schwartz BS, Neistadt B, ... ... Williams DA, et al. Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy. Nature Genetics. 47: 180-5. PMID 25581430 DOI: 10.1038/Ng.3177  1
2015 Forester CM, Sartain SE, Guo D, Harris MH, Weinberg OK, Fleming MD, London WB, Williams DA, Hofmann I. Pediatric aplastic anemia and refractory cytopenia: A retrospective analysis assessing outcomes and histomorphologic predictors. American Journal of Hematology. 90: 320-6. PMID 25580823 DOI: 10.1002/Ajh.23937  1
2015 Zhang MY, Keel SB, Walsh T, Lee MK, Gulsuner S, Watts AC, Pritchard CC, Salipante SJ, Jeng MR, Hofmann I, Williams DA, Fleming MD, Abkowitz JL, King MC, Shimamura A. Genomic analysis of bone marrow failure and myelodysplastic syndromes reveals phenotypic and diagnostic complexity. Haematologica. 100: 42-8. PMID 25239263 DOI: 10.3324/Haematol.2014.113456  1
2014 Bruedigam C, Bagger FO, Heidel FH, Paine Kuhn C, Guignes S, Song A, Austin R, Vu T, Lee E, Riyat S, Moore AS, Lock RB, Bullinger L, Hill GR, Armstrong SA, ... Williams DA, et al. Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy. Cell Stem Cell. 15: 775-90. PMID 25479751 DOI: 10.1016/J.Stem.2014.11.010  1
2014 Hacein-Bey-Abina S, Pai SY, Gaspar HB, Armant M, Berry CC, Blanche S, Bleesing J, Blondeau J, de Boer H, Buckland KF, Caccavelli L, Cros G, De Oliveira S, Fernández KS, Guo D, ... ... Williams DA, et al. A modified γ-retrovirus vector for X-linked severe combined immunodeficiency. The New England Journal of Medicine. 371: 1407-17. PMID 25295500 DOI: 10.1056/Nejmoa1404588  1
2014 Brendel C, Williams DA. Unexpected help: mTOR meets lentiviral vectors. Blood. 124: 832-3. PMID 25104861 DOI: 10.1182/Blood-2014-06-582411  1
2014 Lane SW, Williams DA, Watt FM. Modulating the stem cell niche for tissue regeneration. Nature Biotechnology. 32: 795-803. PMID 25093887 DOI: 10.1038/Nbt.2978  1
2014 Ciuculescu MF, Brendel C, Harris CE, Williams DA. Retroviral transduction of murine and human hematopoietic progenitors and stem cells. Methods in Molecular Biology (Clifton, N.J.). 1185: 287-309. PMID 25062637 DOI: 10.1007/978-1-4939-1133-2_20  1
2014 Renella R, Schlehe JS, Selkoe DJ, Williams DA, LaVoie MJ. Genetic deletion of the GATA1-regulated protein α-synuclein reduces oxidative stress and nitric oxide synthase levels in mature erythrocytes. American Journal of Hematology. 89: 974-7. PMID 25043722 DOI: 10.1002/Ajh.23796  1
2014 Gordon PM, Dias S, Williams DA. Cytokines secreted by bone marrow stromal cells protect c-KIT mutant AML cells from c-KIT inhibitor-induced apoptosis. Leukemia. 28: 2257-60. PMID 25030047 DOI: 10.1038/Leu.2014.212  1
2014 Kiem HP, Baum C, Bushman FD, Byrne BJ, Carter BJ, Cavagnaro J, Malech HL, Mendell JR, Naldini LM, Sorrentino BP, Williams DA, Flotte TR. Charting a clear path: the ASGCT Standardized Pathways Conference. Molecular Therapy : the Journal of the American Society of Gene Therapy. 22: 1235-8. PMID 24981438 DOI: 10.1038/Mt.2014.95  0.04
2014 Keerthivasan G, Mei Y, Zhao B, Zhang L, Harris CE, Gao J, Basiorka AA, Schipma MJ, McElherne J, Yang J, Verma AK, Pellagatti A, Boultwood J, List AF, Williams DA, et al. Aberrant overexpression of CD14 on granulocytes sensitizes the innate immune response in mDia1 heterozygous del(5q) MDS. Blood. 124: 780-90. PMID 24891322 DOI: 10.1182/Blood-2014-01-552463  1
2014 De Vita S, Schneider RK, Garcia M, Wood J, Gavillet M, Ebert BL, Gerbaulet A, Roers A, Levine RL, Mullally A, Williams DA. Loss of function of TET2 cooperates with constitutively active KIT in murine and human models of mastocytosis. Plos One. 9: e96209. PMID 24788138 DOI: 10.1371/Journal.Pone.0096209  1
2014 Williams DA, Thrasher AJ. Concise review: lessons learned from clinical trials of gene therapy in monogenic immunodeficiency diseases. Stem Cells Translational Medicine. 3: 636-42. PMID 24682287 DOI: 10.5966/Sctm.2013-0206  1
2014 Cohen IJ, Wolff JE. How long can folinic acid rescue be delayed after high-dose methotrexate without toxicity? Pediatric Blood & Cancer. 61: 7-10. PMID 24038885 DOI: 10.1002/pbc.24770  1
2014 Rose SR, Kim MO, Korbee L, Wilson KA, Ris MD, Eyal O, Sherafat-Kazemzadeh R, Bollepalli S, Harris R, Jeng MR, Williams DA, Smith FO. Oxandrolone for the treatment of bone marrow failure in Fanconi anemia. Pediatric Blood & Cancer. 61: 11-9. PMID 24019220 DOI: 10.1002/Pbc.24617  0.01
2014 Monif M, O'Brien TJ, Drummond KJ, Reid CA, Liubinas SV, Williams DA. P2X7 receptors are a potential novel target for anti-glioma therapies Journal of Inflammation (United Kingdom). 11. DOI: 10.1186/S12950-014-0025-4  1
2014 Forester C, Sartain SE, Guo D, Harris M, Weinberg O, Fleming MD, London WB, Williams DA, Hofmann I. Pediatric Aplastic Anemia and Refractory Cytopenia of Childhood: A Retrospective Single Institutional Analysis to Determine Outcomes and Histomorphological Predictors Blood. 124: 4382-4382. DOI: 10.1182/Blood.V124.21.4382.4382  1
2014 Lehmann LE, Williams DA, London WB, Agarwal S. A Prospective Trial of Minimal Intensity Conditioning with Fludarabine and Anti-CD52 Antibody Alone in Dyskeratosis Congenita Biology of Blood and Marrow Transplantation. 20. DOI: 10.1016/J.Bbmt.2013.12.266  1
2014 Lane SW, Sykes SM, Al-Shahrour F, Shterental S, Paktinat M, Lo Celso C, Jesneck JL, Ebert BL, Williams DA, Gilliland DG. The Apcmin mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS Blood. 123: 3489-3497.  1
2013 Troeger A, Chae HD, Senturk M, Wood J, Williams DA. A unique carboxyl-terminal insert domain in the hematopoietic-specific, GTPase-deficient Rho GTPase RhoH regulates post-translational processing. The Journal of Biological Chemistry. 288: 36451-62. PMID 24189071 DOI: 10.1074/Jbc.M113.505727  1
2013 Williams DA. Broadening the indications for hematopoietic stem cell genetic therapies. Cell Stem Cell. 13: 263-4. PMID 24012366 DOI: 10.1016/J.Stem.2013.08.006  0.01
2013 Pannucci NL, Li D, Sahay S, Thomas EK, Chen R, Tala I, Hu T, Ciccarelli BT, Megjugorac NJ, Adams Iii HC, Rodriguez PL, Fitzpatrick ER, Lagunoff D, Williams DA, Whitehead IP. Loss of the xeroderma pigmentosum group B protein binding site impairs p210 BCR/ABL1 leukemogenic activity. Blood Cancer Journal. 3: e135. PMID 23955590 DOI: 10.1038/Bcj.2013.36  1
2013 Troeger A, Williams DA. Hematopoietic-specific Rho GTPases Rac2 and RhoH and human blood disorders. Experimental Cell Research. 319: 2375-83. PMID 23850828 DOI: 10.1016/J.Yexcr.2013.07.002  1
2013 Mullally A, Bruedigam C, Poveromo L, Heidel FH, Purdon A, Vu T, Austin R, Heckl D, Breyfogle LJ, Kuhn CP, Kalaitzidis D, Armstrong SA, Williams DA, Hill GR, Ebert BL, et al. Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-α in a murine model of polycythemia vera. Blood. 121: 3692-702. PMID 23487027 DOI: 10.1182/Blood-2012-05-432989  1
2013 Dorrance AM, De Vita S, Radu M, Reddy PN, McGuinness MK, Harris CE, Mathieu R, Lane SW, Kosoff R, Milsom MD, Chernoff J, Williams DA. The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment. Blood. 121: 2474-82. PMID 23335370 DOI: 10.1182/Blood-2012-10-460709  1
2013 Tala I, Chen R, Hu T, Fitzpatrick ER, Williams DA, Whitehead IP. Contributions of the RhoGEF activity of p210 BCR/ABL to disease progression. Leukemia. 27: 1080-9. PMID 23207522 DOI: 10.1038/Leu.2012.351  1
2013 Hacein-Bey-Abina S, Bushman F, Armant M, Blanche S, Blondeau J, Caccavelli L, Daley H, Dansereau C, deOliveira S, Guo D, Hopkins G, Lim A, Sci M, London WB, Malani N, ... ... Williams DA, et al. Immune Reconstitution and Preliminary Safety Analysis Of 9 Patients Treated With Somatic Gene Therapy For X-Linked Severe Combined Immunodeficiency (SCID-X1) With a Self-Inactivating Gammaretroviral Vector Blood. 122: 715-715. DOI: 10.1182/Blood.V122.21.715.715  1
2013 Keerthivasan G, Zhao B, Harris CE, Zhang L, Gao J, McElherne J, Yang J, Basiorka AA, Schipma M, Boultwood J, Verma A, List A, Williams DA, Ji P. Aberrant Overexpression Of CD14 In Granulocytes Sensitizes Innate Immune Response In mDia1 Heterozygous Myelodysplastic Syndromes Blood. 122: 1557-1557. DOI: 10.1182/Blood.V122.21.1557.1557  1
2012 Crequer A, Troeger A, Patin E, Ma CS, Picard C, Pedergnana V, Fieschi C, Lim A, Abhyankar A, Gineau L, Mueller-Fleckenstein I, Schmidt M, Taieb A, Krueger J, Abel L, ... ... Williams DA, et al. Human RHOH deficiency causes T cell defects and susceptibility to EV-HPV infections. The Journal of Clinical Investigation. 122: 3239-47. PMID 22850876 DOI: 10.1172/Jci62949  1
2012 Chang KH, Sanchez-Aguilera A, Shen S, Sengupta A, Madhu MN, Ficker AM, Dunn SK, Kuenzi AM, Arnett JL, Santho RA, Agirre X, Perentesis JP, Deininger MW, Zheng Y, Bustelo XR, ... Williams DA, et al. Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival. Blood. 120: 800-11. PMID 22692505 DOI: 10.1182/Blood-2011-06-361709  1
2012 van der Loo JC, Swaney WP, Grassman E, Terwilliger A, Higashimoto T, Schambach A, Hacein-Bey-Abina S, Nordling DL, Cavazzana-Calvo M, Thrasher AJ, Williams DA, Reeves L, Malik P. Critical variables affecting clinical-grade production of the self-inactivating gamma-retroviral vector for the treatment of X-linked severe combined immunodeficiency. Gene Therapy. 19: 872-6. PMID 22551777 DOI: 10.1038/Gt.2012.37  1
2012 Keller RB, Gagne KE, Usmani GN, Asdourian GK, Williams DA, Hofmann I, Agarwal S. CTC1 Mutations in a patient with dyskeratosis congenita. Pediatric Blood & Cancer. 59: 311-4. PMID 22532422 DOI: 10.1002/Pbc.24193  1
2012 Troeger A, Johnson AJ, Wood J, Blum WG, Andritsos LA, Byrd JC, Williams DA. RhoH is critical for cell-microenvironment interactions in chronic lymphocytic leukemia in mice and humans. Blood. 119: 4708-18. PMID 22474251 DOI: 10.1182/Blood-2011-12-395939  1
2012 Konstantinidis DG, Pushkaran S, Johnson JF, Cancelas JA, Manganaris S, Harris CE, Williams DA, Zheng Y, Kalfa TA. Signaling and cytoskeletal requirements in erythroblast enucleation. Blood. 119: 6118-27. PMID 22461493 DOI: 10.1182/Blood-2011-09-379263  1
2012 Nieborowska-Skorska M, Kopinski PK, Ray R, Hoser G, Ngaba D, Flis S, Cramer K, Reddy MM, Koptyra M, Penserga T, Glodkowska-Mrowka E, Bolton E, Holyoake TL, Eaves CJ, Cerny-Reiterer S, ... ... Williams DA, et al. Rac2-MRC-cIII-generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors. Blood. 119: 4253-63. PMID 22411871 DOI: 10.1182/Blood-2011-10-385658  1
2012 Müller LU, Milsom MD, Harris CE, Vyas R, Brumme KM, Parmar K, Moreau LA, Schambach A, Park IH, London WB, Strait K, Schlaeger T, Devine AL, Grassman E, D'Andrea A, ... ... Williams DA, et al. Overcoming reprogramming resistance of Fanconi anemia cells. Blood. 119: 5449-57. PMID 22371882 DOI: 10.1182/Blood-2012-02-408674  1
2012 Brennig S, Rattmann I, Lachmann N, Schambach A, Williams DA, Moritz T. In vivo enrichment of cytidine deaminase gene-modified hematopoietic cells by prolonged cytosine-arabinoside application. Cytotherapy. 14: 451-60. PMID 22242831 DOI: 10.3109/14653249.2011.646043  0.01
2012 Lane SW, De Vita S, Alexander KA, Karaman R, Milsom MD, Dorrance AM, Purdon A, Louis L, Bouxsein ML, Williams DA. Rac signaling in osteoblastic cells is required for normal bone development but is dispensable for hematopoietic development. Blood. 119: 736-44. PMID 22123845 DOI: 10.1182/Blood-2011-07-368753  1
2012 van der Loo JC, Swaney WP, Grassman E, Terwilliger A, Higashimoto T, Schambach A, Baum C, Thrasher AJ, Williams DA, Nordling DL, Reeves L, Malik P. Scale-up and manufacturing of clinical-grade self-inactivating γ-retroviral vectors by transient transfection. Gene Therapy. 19: 246-54. PMID 21753795 DOI: 10.1038/Gt.2011.102  1
2011 Mondal S, Ghosh-Roy S, Loison F, Li Y, Jia Y, Harris C, Williams DA, Luo HR. PTEN negatively regulates engulfment of apoptotic cells by modulating activation of Rac GTPase. Journal of Immunology (Baltimore, Md. : 1950). 187: 5783-94. PMID 22043008 DOI: 10.4049/Jimmunol.1100484  1
2011 Mizukawa B, Wei J, Shrestha M, Wunderlich M, Chou FS, Griesinger A, Harris CE, Kumar AR, Zheng Y, Williams DA, Mulloy JC. Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia. Blood. 118: 5235-45. PMID 21940819 DOI: 10.1182/Blood-2011-04-351817  1
2011 Lane SW, Wang YJ, Lo Celso C, Ragu C, Bullinger L, Sykes SM, Ferraro F, Shterental S, Lin CP, Gilliland DG, Scadden DT, Armstrong SA, Williams DA. Differential niche and Wnt requirements during acute myeloid leukemia progression Blood. 118: 2849-2856. PMID 21765021 DOI: 10.1182/Blood-2011-03-345165  1
2011 Mease PJ, Clauw DJ, Christensen R, Crofford LJ, Gendreau RM, Martin SA, Simon LS, Strand V, Williams DA, Arnold LM. Toward development of a fibromyalgia responder index and disease activity score: OMERACT module update. The Journal of Rheumatology. 38: 1487-95. PMID 21724721 DOI: 10.3899/Jrheum.110277  1
2011 Sanchez-Aguilera A, Lee YJ, Lo Celso C, Ferraro F, Brumme K, Mondal S, Kim C, Dorrance A, Luo HR, Scadden DT, Williams DA. Guanine nucleotide exchange factor Vav1 regulates perivascular homing and bone marrow retention of hematopoietic stem and progenitor cells. Proceedings of the National Academy of Sciences of the United States of America. 108: 9607-12. PMID 21606370 DOI: 10.1073/Pnas.1102018108  1
2011 Strober BE, Crowley JJ, Yamauchi PS, Olds M, Williams DA. Efficacy and safety results from a phase III, randomized controlled trial comparing the safety and efficacy of briakinumab with etanercept and placebo in patients with moderate to severe chronic plaque psoriasis. The British Journal of Dermatology. 165: 661-8. PMID 21574984 DOI: 10.1111/J.1365-2133.2011.10419.X  1
2011 Gottlieb AB, Leonardi C, Kerdel F, Mehlis S, Olds M, Williams DA. Efficacy and safety of briakinumab vs. etanercept and placebo in patients with moderate to severe chronic plaque psoriasis. The British Journal of Dermatology. 165: 652-60. PMID 21574983 DOI: 10.1111/J.1365-2133.2011.10418.X  1
2011 Tolar J, Adair JE, Antoniou M, Bartholomae CC, Becker PS, Blazar BR, Bueren J, Carroll T, Cavazzana-Calvo M, Clapp DW, Dalgleish R, Galy A, Gaspar HB, Hanenberg H, Von Kalle C, ... ... Williams DA, et al. Stem cell gene therapy for fanconi anemia: report from the 1st international Fanconi anemia gene therapy working group meeting. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 1193-8. PMID 21540837 DOI: 10.1038/Mt.2011.78  1
2011 Williams DA, Thrasher AJ. Out of harm's way Nature Biotechnology. 29: 41-42. PMID 21221100 DOI: 10.1038/Nbt.1750  1
2011 Mahajan MK, Uttamsingh V, Daniels JS, Gan LS, LeDuc BW, Williams DA. In vitro metabolism of oxymetazoline: evidence for bioactivation to a reactive metabolite. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 39: 693-702. PMID 21177487 DOI: 10.1124/Dmd.110.036004  1
2011 Adams BEL, Kyi M, Reid CA, Myers DE, Xu S, Williams DA, O'Brien TJ. Seizure-like thalamocortical rhythms initiate in the deep layers of the cortex in a co-culture model Experimental Neurology. 227: 203-209. PMID 21075104 DOI: 10.1016/J.Expneurol.2010.11.001  1
2011 Mahajan MK, Uttamsingh V, Gan LS, Leduc B, Williams DA. Identification and characterization of oxymetazoline glucuronidation in human liver microsomes: evidence for the involvement of UGT1A9. Journal of Pharmaceutical Sciences. 100: 784-93. PMID 20669329 DOI: 10.1002/Jps.22303  1
2010 Williams DA. Hematology grants workshop Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 2010: 189-190. PMID 21239792 DOI: 10.1182/Asheducation-2010.1.189  1
2010 Chae HD, Siefring JE, Hildeman DA, Gu Y, Williams DA. RhoH regulates subcellular localization of ZAP-70 and Lck in T cell receptor signaling. Plos One. 5: e13970. PMID 21103055 DOI: 10.1371/Journal.Pone.0013970  1
2010 Williams DA, Thrasher AJ, Baum C. Transatlantic consortium spotlights need for changes in gene therapy trials Molecular Therapy. 18: 1892. PMID 21042294 DOI: 10.1038/Mt.2010.227  1
2010 Williams DA, Porter ES, Lux SE, Grier HE, Mack JW, Orkin SH. Training program in cancer and blood diseases: Pediatric Hematology/Oncology Fellowship Program, Children's Hospital Boston/Dana-Farber Cancer Institute. American Journal of Hematology. 85: 793-4. PMID 20730793 DOI: 10.1002/Ajh.21816  1
2010 Monif M, Burnstock G, Williams DA. Microglia: proliferation and activation driven by the P2X7 receptor. The International Journal of Biochemistry & Cell Biology. 42: 1753-6. PMID 20599520 DOI: 10.1016/J.Biocel.2010.06.021  1
2010 Hay WW, Gitterman DP, Williams DA, Dover GJ, Sectish TC, Schleiss MR. Child health research funding and policy: imperatives and investments for a healthier world. Pediatrics. 125: 1259-65. PMID 20457684 DOI: 10.1542/Peds.2009-2635  1
2010 Sengupta A, Arnett J, Dunn S, Williams DA, Cancelas JA. Rac2 GTPase deficiency depletes BCR-ABL+ leukemic stem cells and progenitors in vivo. Blood. 116: 81-4. PMID 20407032 DOI: 10.1182/Blood-2009-10-247437  1
2010 Williams DA. The American Society of Pediatric Hematology/Oncology (ASPHO) 2010 Distinguished Career Award Goes to Dr. Sam Lux Pediatric Blood &Amp; Cancer. 54: 785-786. PMID 20229496 DOI: 10.1002/Pbc.22473  1
2010 Lane SW, Sykes SM, Al-Shahrour F, Shterental S, Paktinat M, Lo Celso C, Jesneck JL, Ebert BL, Williams DA, Gilliland DG. The Apc(min) mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS. Blood. 115: 3489-97. PMID 20197553 DOI: 10.1182/Blood-2009-11-251728  1
2010 Kalfa TA, Pushkaran S, Zhang X, Johnson JF, Pan D, Daria D, Geiger H, Cancelas JA, Williams DA, Zheng Y. Rac1 and Rac2 GTPases are necessary for early erythropoietic expansion in the bone marrow but not in the spleen. Haematologica. 95: 27-35. PMID 20065081 DOI: 10.3324/Haematol.2009.006239  1
2010 Chen M, LeDuc B, Kerr S, Howe D, Williams DA. Identification of human UGT2B7 as the major isoform involved in the O-glucuronidation of chloramphenicol. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 38: 368-75. PMID 20008037 DOI: 10.1124/Dmd.109.029900  1
2010 Sanchez-Aguilera A, Rattmann I, Drew DZ, Müller LU, Summey V, Lucas DM, Byrd JC, Croce CM, Gu Y, Cancelas JA, Johnston P, Moritz T, Williams DA. Involvement of RhoH GTPase in the development of B-cell chronic lymphocytic leukemia. Leukemia. 24: 97-104. PMID 19847197 DOI: 10.1038/Leu.2009.217  1
2010 Barrett GL, Reid CA, Tsafoulis C, Zhu W, Williams DA, Paolini AG, Trieu J, Murphy M. Enhanced spatial memory and hippocampal long-term potentiation in p75 neurotrophin receptor knockout mice. Hippocampus. 20: 145-52. PMID 19360854 DOI: 10.1002/Hipo.20598  1
2010 Lane SW, Sykes SM, Ferraro F, Lin CP, Gilliland DG, Williams DA, Scadden DT, Celso CL. Leukemia stem cells occupy niches that are physically distinct and independent of the normal constraints that apply to hematopoietic stem cells Experimental Hematology. 38. DOI: 10.1016/J.Exphem.2010.07.008  1
2009 Williams DA. Correction and apology Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 1660. PMID 19789558 DOI: 10.1038/Mt.2009.212  1
2009 Williams DA. National institutes of health releases new guidelines on human stem cell research Molecular Therapy. 17: 1485-1486. PMID 19721416 DOI: 10.1038/Mt.2009.191  1
2009 Xu H, Eleswarapu S, Geiger H, Szczur K, Daria D, Zheng Y, Settleman J, Srour EF, Williams DA, Filippi MD. Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential. Blood. 114: 3557-66. PMID 19713466 DOI: 10.1182/Blood-2009-02-205815  1
2009 Williams DA. Gene therapy continues to mature and to face challenges Molecular Therapy. 17: 1305-1306. PMID 19644491 DOI: 10.1038/Mt.2009.162  1
2009 Adams BEL, Reid CA, Myers D, Ng C, Powell K, Phillips AM, Zheng T, O'Brien TJ, Williams DA. Excitotoxic-mediated transcriptional decreases in HCN2 channel function increase network excitability in CA1 Experimental Neurology. 219: 249-257. PMID 19500574 DOI: 10.1016/J.Expneurol.2009.05.030  1
2009 Williams DA. Rapid development of pluripotent stem cells as a potential therapeutic modality Molecular Therapy. 17: 929-930. PMID 19483764 DOI: 10.1038/Mt.2009.97  0.32
2009 Singh TR, Bakker ST, Agarwal S, Jansen M, Grassman E, Godthelp BC, Ali AM, Du CH, Rooimans MA, Fan Q, Wahengbam K, Steltenpool J, Andreassen PR, Williams DA, Joenje H, et al. Impaired FANCD2 monoubiquitination and hypersensitivity to camptothecin uniquely characterize Fanconi anemia complementation group M. Blood. 114: 174-80. PMID 19423727 DOI: 10.1182/Blood-2009-02-207811  1
2009 Ali AM, Kirby M, Jansen M, Lach FP, Schulte J, Singh TR, Batish SD, Auerbach AD, Williams DA, Meetei AR. Identification and characterization of mutations in FANCL gene: a second case of Fanconi anemia belonging to FA-L complementation group. Human Mutation. 30: E761-70. PMID 19405097 DOI: 10.1002/Humu.21032  1
2009 Williams DA. Recombinant DNA advisory committee updates recommendations on gene transfer for X-linked severe combined immunodeficiency Molecular Therapy. 17: 751-752. PMID 19404322 DOI: 10.1038/Mt.2009.76  1
2009 Williams DA. Progress in genetic therapy for severe combined immunodeficiency associated with adenosine deaminase deficiency Molecular Therapy. 17: 577-578. PMID 19337228 DOI: 10.1038/Mt.2009.57  1
2009 Monif M, Reid CA, Powell KL, Smart ML, Williams DA. The P2X7 receptor drives microglial activation and proliferation: A trophic role for P2X7R pore Journal of Neuroscience. 29: 3781-3791. PMID 19321774 DOI: 10.1523/Jneurosci.5512-08.2009  1
2009 Milsom MD, Schiedlmeier B, Bailey J, Kim MO, Li D, Jansen M, Ali AM, Kirby M, Baum C, Fairbairn LJ, Williams DA. Ectopic HOXB4 overcomes the inhibitory effect of tumor necrosis factor-{alpha} on Fanconi anemia hematopoietic stem and progenitor cells. Blood. 113: 5111-20. PMID 19270262 DOI: 10.1182/Blood-2008-09-180224  1
2009 Williams DA. New approaches in the potential treatment of HIV-acquired immunodeficiency disease Molecular Therapy. 17: 209-210. PMID 19180109 DOI: 10.1038/Mt.2008.302  0.32
2009 Williams DA. ESCGT 2008: Progress in clinical gene therapy Molecular Therapy. 17: 1-2. PMID 19116631 DOI: 10.1038/Mt.2008.277  1
2009 Hoskins EE, Morris TA, Higginbotham JM, Spardy N, Cha E, Kelly P, Williams DA, Wikenheiser-Brokamp KA, Duensing S, Wells SI. Fanconi anemia deficiency stimulates HPV-associated hyperplastic growth in organotypic epithelial raft culture. Oncogene. 28: 674-85. PMID 19015634 DOI: 10.1038/Onc.2008.416  1
2009 Williams DA. Editorial: Molecular therapy moves on to a new editor-in-chief Molecular Therapy. 17: 1989-1990. DOI: 10.1038/mt.2009.259  1
2008 Müller LU, Milsom MD, Kim MO, Schambach A, Schuesler T, Williams DA. Rapid Lentiviral Transduction Preserves the Engraftment Potential of Fanca(-/-) Hematopoietic Stem Cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 1154-1160. PMID 28178472 DOI: 10.1038/Mt.2008.67  1
2008 Gan B, Sahin E, Jiang S, Sanchez-Aguilera A, Scott KL, Chin L, Williams DA, Kwiatkowski DJ, DePinho RA. mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization. Proceedings of the National Academy of Sciences of the United States of America. 105: 19384-9. PMID 19052232 DOI: 10.1073/Pnas.0810584105  1
2008 Sevigny CP, Bassi J, Teschemacher AG, Kim KS, Williams DA, Anderson CR, Allen AM. C1 neurons in the rat rostral ventrolateral medulla differentially express vesicular monoamine transporter 2 in soma and axonal compartments. The European Journal of Neuroscience. 28: 1536-44. PMID 18973576 DOI: 10.1111/J.1460-9568.2008.06445.X  1
2008 Williams DA. Sleeping beauty vector system moves toward human trials in the United States Molecular Therapy. 16: 1515-1516. PMID 18725873 DOI: 10.1038/Mt.2008.169  1
2008 Milsom MD, Jerabek-Willemsen M, Harris CE, Schambach A, Broun E, Bailey J, Jansen M, Schleimer D, Nattamai K, Wilhelm J, Watson A, Geiger H, Margison GP, Moritz T, Baum C, ... ... Williams DA, et al. Reciprocal relationship between O6-methylguanine-DNA methyltransferase P140K expression level and chemoprotection of hematopoietic stem cells. Cancer Research. 68: 6171-80. PMID 18676840 DOI: 10.1158/0008-5472.Can-08-0320  1
2008 Müller LU, Schore RJ, Zheng Y, Thomas EK, Kim MO, Cancelas JA, Gu Y, Williams DA. Rac guanosine triphosphatases represent a potential target in AML. Leukemia. 22: 1803-6. PMID 18668135 DOI: 10.1038/Leu.2008.196  1
2008 Reid CA, Adams BEL, Myers D, O'Brien TJ, Williams DA. Sub region-specific modulation of synchronous neuronal burst firing after a kainic acid insult in organotypic hippocampal cultures Bmc Neuroscience. 9. PMID 18593482 DOI: 10.1186/1471-2202-9-59  1
2008 Williams DA. Progress reported in two studies of clinical gene transfer into the retina Molecular Therapy. 16: 1181. PMID 18574492 DOI: 10.1038/Mt.2008.123  1
2008 Zhang X, Shang X, Guo F, Murphy K, Kirby M, Kelly P, Reeves L, Smith FO, Williams DA, Zheng Y, Pang Q. Defective homing is associated with altered Cdc42 activity in cells from patients with Fanconi anemia group A. Blood. 112: 1683-6. PMID 18565850 DOI: 10.1182/Blood-2008-03-147090  1
2008 Yamada Y, Sanchez-Aguilera A, Brandt EB, McBride M, Al-Moamen NJ, Finkelman FD, Williams DA, Cancelas JA, Rothenberg ME. FIP1L1/PDGFRalpha synergizes with SCF to induce systemic mastocytosis in a murine model of chronic eosinophilic leukemia/hypereosinophilic syndrome. Blood. 112: 2500-7. PMID 18539901 DOI: 10.1182/Blood-2007-11-126268  1
2008 Sadelain M, Williams DA. A "vector drain" in US gene therapy development? Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 801-2. PMID 18432266 DOI: 10.1038/Mt.2008.71  1
2008 Müller LU, Milsom MD, Kim MO, Schambach A, Schuesler T, Williams DA. Rapid lentiviral transduction preserves the engraftment potential of Fanca(-/-) hematopoietic stem cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 1154-60. PMID 18398427 DOI: 10.1038/mt.2008.67  1
2008 Powell KL, Ng C, O'Brien T, Xu SH, Williams DA, Foote S, Reid CA. Decreases in HCN mRNA expression in the hippocampus after kindling and status epilepticus in adult rats Epilepsia. 49: 1686-1695. PMID 18397293 DOI: 10.1111/J.1528-1167.2008.01593.X  1
2008 Williams DA. Foamy virus vectors come of age Molecular Therapy. 16: 635. PMID 18362918 DOI: 10.1038/Mt.2008.34  1
2008 Thomas EK, Cancelas JA, Zheng Y, Williams DA. Rac GTPases as key regulators of p210-BCR-ABL-dependent leukemogenesis. Leukemia. 22: 898-904. PMID 18354486 DOI: 10.1038/Leu.2008.71  1
2008 Reid CA, Xu S, Williams DA. Spontaneous release from mossy fiber terminals inhibits Ni 2+-sensitive T-type Ca2+ channels of CA30 pyramidal neurons in the rat organotypic hippocampal slice Hippocampus. 18: 623-630. PMID 18306285 DOI: 10.1002/Hipo.20419  1
2008 Williams DA. NIH recombinant DNA advisory committee continues to ponder adverse event associated with AAV gene therapy trial Molecular Therapy. 16: 427-428. PMID 18297091 DOI: 10.1038/Mt.2008.2  1
2008 Thornhill SI, Schambach A, Howe SJ, Ulaganathan M, Grassman E, Williams D, Schiedlmeier B, Sebire NJ, Gaspar HB, Kinnon C, Baum C, Thrasher AJ. Self-inactivating gammaretroviral vectors for gene therapy of X-linked severe combined immunodeficiency. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 590-8. PMID 18180772 DOI: 10.1038/Sj.Mt.6300393  1
2008 Milsom MD, Schiedlmeier B, Bailey J, Schambach A, Baum C, Kirby M, Ali A, Meetei R, Grassman E, Williams DA. Too little, too late: The initial experience in FA gene therapy Blood Cells Molecules and Diseases. 40: 291-292. DOI: 10.1016/J.Bcmd.2007.10.090  1
2007 Williams DA. An international conversation on stem cell gene therapy Molecular Therapy. 15: 2058-2059. PMID 18026181 DOI: 10.1038/Sj.Mt.6300358  1
2007 Williams DA. RAC reviews serious adverse event associated with AAV therapy trial Molecular Therapy. 15: 2053-2054. PMID 18026178 DOI: 10.1038/Sj.Mt.6300352  1
2007 Thomas EK, Cancelas JA, Chae HD, Cox AD, Keller PJ, Perrotti D, Neviani P, Druker BJ, Setchell KD, Zheng Y, Harris CE, Williams DA. Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease. Cancer Cell. 12: 467-78. PMID 17996650 DOI: 10.1016/J.Ccr.2007.10.015  1
2007 Chen M, Howe D, Leduc B, Kerr S, Williams DA. Identification and characterization of two chloramphenicol glucuronides from the in vitro glucuronidation of chloramphenicol in human liver microsomes Xenobiotica. 37: 954-971. PMID 17896323 DOI: 10.1080/00498250701620734  1
2007 Williams DA. A new mechanism of leukemia drug resistance? New England Journal of Medicine. 357: 77-78. PMID 17611211 DOI: 10.1056/Nejmcibr072412  1
2007 Williams DA. NIH decides against continuing NGVLs in their current form Molecular Therapy. 15: 1223. PMID 17579591 DOI: 10.1038/Sj.Mt.6300226  1
2007 Ball CR, Pilz IH, Schmidt M, Fessler S, Williams DA, Von Kalle C, Glimm H. Stable differentiation and clonality of murine long-term hematopoiesis after extended reduced-intensity selection for MGMT P140K transgene expression Blood. 110: 1779-1787. PMID 17496202 DOI: 10.1182/Blood-2006-11-053710  1
2007 Williams DA. Are lentivirus vectors safer? Molecular Therapy. 15: 439. PMID 17311027 DOI: 10.1038/Sj.Mt.6300111  1
2007 Will E, Bailey J, Schuesler T, Modlich U, Balcik B, Burzynski B, Witte D, Layh-Schmitt G, Rudolph C, Schlegelberger B, von Kalle C, Baum C, Sorrentino BP, Wagner LM, Kelly P, ... ... Williams DA, et al. Importance of murine study design for testing toxicity of retroviral vectors in support of phase I trials. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 782-91. PMID 17299409 DOI: 10.1038/Sj.Mt.6300083  1
2007 Sherafat-Kazemzadeh R, Mehta SN, Care MM, Kim MO, Williams DA, Rose SR. Small pituitary size in children with Fanconi anemia. Pediatric Blood & Cancer. 49: 166-70. PMID 17274008 DOI: 10.1002/Pbc.21148  1
2007 Kelly PF, Radtke S, von Kalle C, Balcik B, Bohn K, Mueller R, Schuesler T, Haren M, Reeves L, Cancelas JA, Leemhuis T, Harris R, Auerbach AD, Smith FO, Davies SM, ... Williams DA, et al. Stem cell collection and gene transfer in Fanconi anemia. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 211-9. PMID 17164793 DOI: 10.1038/Sj.Mt.6300033  1
2007 Williams DA. ASGT advises NIH on funding of gene therapy trials Molecular Therapy. 15: 1-2. PMID 17164764 DOI: 10.1038/Sj.Mt.6300051  1
2007 Mehta PA, Ileri T, Harris RE, Williams DA, Mo J, Smolarek T, Auerbach AD, Kelly P, Davies SM. Chemotherapy for myeloid malignancy in children with Fanconi anemia. Pediatric Blood & Cancer. 48: 668-72. PMID 16609946 DOI: 10.1002/Pbc.20843  1
2007 Williams DA. AAV and insertional mutagenesis Molecular Therapy. 15: 1737. DOI: 10.1038/sj.mt.6300301  1
2007 Williams DA. Of mouse models and men Molecular Therapy. 15: 643. DOI: 10.1038/sj.mt.6300133  1
2006 Williams DA. NIH Funding of Gene Therapy Trials Molecular Therapy. 14: 607. PMID 16979942 DOI: 10.1016/J.Ymthe.2006.09.004  1
2006 Kalfa TA, Pushkaran S, Mohandas N, Hartwig JH, Fowler VM, Johnson JF, Joiner CH, Williams DA, Zheng Y. Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton. Blood. 108: 3637-45. PMID 16882712 DOI: 10.1182/Blood-2006-03-005942  1
2006 Cancelas JA, Jansen M, Williams DA. The role of chemokine activation of Rac GTPases in hematopoietic stem cell marrow homing, retention, and peripheral mobilization. Experimental Hematology. 34: 976-85. PMID 16863904 DOI: 10.1016/J.Exphem.2006.03.016  1
2006 Williams DA. A Pox on Your Tumor Molecular Therapy. 14: 313. PMID 16844420 DOI: 10.1016/J.Ymthe.2006.07.002  1
2006 Schambach A, Galla M, Modlich U, Will E, Chandra S, Reeves L, Colbert M, Williams DA, von Kalle C, Baum C. Lentiviral vectors pseudotyped with murine ecotropic envelope: increased biosafety and convenience in preclinical research. Experimental Hematology. 34: 588-92. PMID 16647564 DOI: 10.1016/J.Exphem.2006.02.005  1
2006 Cornetta K, Croop J, Dropcho E, Abonour R, Kieran MW, Kreissman S, Reeves L, Erickson LC, Williams DA. A pilot study of dose-intensified procarbazine, CCNU, vincristine for poor prognosis brain tumors utilizing fibronectin-assisted, retroviral-mediated modification of CD34+ peripheral blood cells with O6-methylguanine DNA methyltransferase. Cancer Gene Therapy. 13: 886-95. PMID 16645619 DOI: 10.1038/Sj.Cgt.7700963  1
2006 Williams DA. An emerging consensus on recommendations to facilitate clinical gene transfer Molecular Therapy. 13: 637-638. PMID 16530487 DOI: 10.1016/J.Ymthe.2006.03.003  1
2006 Schambach A, Bohne J, Chandra S, Will E, Margison GP, Williams DA, Baum C. Equal potency of gammaretroviral and lentiviral SIN vectors for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. 13: 391-400. PMID 16226060 DOI: 10.1016/J.Ymthe.2005.08.012  1
2005 Williams DA. FDA guidance document on monitoring delayed adverse events a good first start Molecular Therapy. 12: 991-992. PMID 16271514 DOI: 10.1016/J.Ymthe.2005.10.011  1
2005 Cripe TP, Thomson B, Boat TF, Williams DA. Promoting translational research in academic health centers: navigating the "roadmap". Academic Medicine : Journal of the Association of American Medical Colleges. 80: 1012-8. PMID 16249299 DOI: 10.1097/00001888-200511000-00008  1
2005 Chandra S, Levran O, Jurickova I, Maas C, Kapur R, Schindler D, Henry R, Milton K, Batish SD, Cancelas JA, Hanenberg H, Auerbach AD, Williams DA. A rapid method for retrovirus-mediated identification of complementation groups in Fanconi anemia patients. Molecular Therapy : the Journal of the American Society of Gene Therapy. 12: 976-84. PMID 16084127 DOI: 10.1016/J.Ymthe.2005.04.021  1
2005 Williams DA. A balanced decision? Regulatory reaction to the "Third Case" Molecular Therapy. 11: 819-821. PMID 15922952 DOI: 10.1016/J.Ymthe.2005.04.010  1
2005 Carstanjen D, Yamauchi A, Koornneef A, Zang H, Filippi MD, Harris C, Towe J, Atkinson S, Zheng Y, Dinauer MC, Williams DA. Rac2 regulates neutrophil chemotaxis, superoxide production, and myeloid colony formation through multiple distinct effector pathways. Journal of Immunology (Baltimore, Md. : 1950). 174: 4613-20. PMID 15814684 DOI: 10.4049/Jimmunol.174.8.4613  1
2005 Jansen M, Yang FC, Cancelas JA, Bailey JR, Williams DA. Rac2-deficient hematopoietic stem cells show defective interaction with the hematopoietic microenvironment and long-term engraftment failure. Stem Cells (Dayton, Ohio). 23: 335-46. PMID 15749928 DOI: 10.1634/stemcells.2004-0216  1
2005 Williams DA. The NIH roadmap: Timing is everything Molecular Therapy. 11: 173. PMID 15668128 DOI: 10.1016/J.Ymthe.2005.01.002  1
2005 Schambach A, Bohne J, Chandra S, Will E, Mueller L, Margison G, Williams DA, Baum C. 829. Design of a Safe and Efficient Vector for Bone Marrow Chemoprotection by O6-Methyl-Guanine-DNA-MethylTransferase Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.372  1
2005 Williams DA. A new year and a renewed mission Molecular Therapy. 11: 1. DOI: 10.1016/J.Ymthe.2004.11.010  1
2005 Villella AD, Yao J, Getty RR, Juliar BE, Yiannoutsos C, Hartwell JR, Cai S, Sadat MA, Cornetta K, Williams DA, Pollok KE. Real-Time PCR: An effective tool for measuring transduction efficiency in human hematopoietic progenitor cells Molecular Therapy. 11: 483-491. DOI: 10.1016/j.ymthe.2004.10.017  1
2004 Monif M, Smart ML, Reid CA, Williams DA. Development of low-affinity, membrane-targeted Ca2+ sensors suitable for measuring presynaptic Ca2+ Clinical and Experimental Pharmacology and Physiology. 31: 885-889. PMID 15659054 DOI: 10.1111/J.1440-1681.2004.04098.X  1
2004 Filippi MD, Harris CE, Meller J, Gu Y, Zheng Y, Williams DA. Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophils. Nature Immunology. 5: 744-51. PMID 15170212 DOI: 10.1038/Ni1081  1
2004 Murry CE, Soonpaa MH, Reinecke H, Nakajima H, Nakajima HO, Rubart M, Pasumarthi KB, Virag JI, Bartelmez SH, Poppa V, Bradford G, Dowell JD, Williams DA, Field LJ. Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature. 428: 664-8. PMID 15034593 DOI: 10.1038/Nature02446  1
2004 Narayanan R, LeDuc B, Williams DA. Glucuronidation of haloperidol by rat liver microsomes: involvement of family 2 UDP-glucuronosyltransferases. Life Sciences. 74: 2527-39. PMID 15010263 DOI: 10.1016/J.Lfs.2003.10.009  1
2003 Yang FC, Ingram DA, Chen S, Hingtgen CM, Ratner N, Monk KR, Clegg T, White H, Mead L, Wenning MJ, Williams DA, Kapur R, Atkinson SJ, Clapp DW. Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/- mast cells. The Journal of Clinical Investigation. 112: 1851-61. PMID 14679180 DOI: 10.1172/Jci19195  1
2003 Pollok KE, Hartwell JR, Braber A, Cooper RJ, Jansen M, Ragg S, Bailey BJ, Erickson LC, Kreklau EL, Williams DA. In vivo selection of human hematopoietic cells in a xenograft model using combined pharmacologic and genetic manipulations. Human Gene Therapy. 14: 1703-14. PMID 14670122 DOI: 10.1089/104303403322611728  1
2003 Gu Y, Filippi MD, Cancelas JA, Siefring JE, Williams EP, Jasti AC, Harris CE, Lee AW, Prabhakar R, Atkinson SJ, Kwiatkowski DJ, Williams DA. Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatases. Science (New York, N.Y.). 302: 445-9. PMID 14564009 DOI: 10.1126/Science.1088485  1
2003 Woods EJ, Liu J, Pollok K, Hartwell J, Smith FO, Williams DA, Yoder MC, Critser JK. A theoretically optimized method for cord blood stem cell cryopreservation. Journal of Hematotherapy & Stem Cell Research. 12: 341-50. PMID 12857375 DOI: 10.1089/152581603322023070  1
2003 Howard V, Myers LA, Williams DA, Wheeler G, Turner EV, Cunningham JM, Conley ME. Stem cell transplants for patients with X-linked agammaglobulinemia. Clinical Immunology (Orlando, Fla.). 107: 98-102. PMID 12763478 DOI: 10.1016/S1521-6616(03)00045-7  1
2003 Leurs C, Jansen M, Pollok KE, Heinkelein M, Schmidt M, Wissler M, Lindemann D, Von Kalle C, Rethwilm A, Williams DA, Hanenberg H. Comparison of three retroviral vector systems for transduction of nonobese diabetic/severe combined immunodeficiency mice repopulating human CD34+ cord blood cells. Human Gene Therapy. 14: 509-19. PMID 12718762 DOI: 10.1089/104303403764539305  1
2002 Bowser DN, Wagner DA, Czajkowski C, Cromer BA, Parker MW, Wallace RH, Harkin LA, Mulley JC, Marini C, Berkovic SF, Williams DA, Jones MV, Petrou S. Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation [gamma 2(R43Q)] found in human epilepsy. Proceedings of the National Academy of Sciences of the United States of America. 99: 15170-5. PMID 12415111 DOI: 10.1073/Pnas.212320199  1
2002 Gu Y, Byrne MC, Paranavitana NC, Aronow B, Siefring JE, D'Souza M, Horton HF, Quilliam LA, Williams DA. Rac2, a hematopoiesis-specific Rho GTPase, specifically regulates mast cell protease gene expression in bone marrow-derived mast cells. Molecular and Cellular Biology. 22: 7645-57. PMID 12370311 DOI: 10.1128/Mcb.22.21.7645-7657.2002  1
2002 Jansen M, Sorg UR, Ragg S, Flasshove M, Seeber S, Williams DA, Moritz T. Hematoprotection and enrichment of transduced cells in vivo after gene transfer of MGMT(P140K) into hematopoietic stem cells. Cancer Gene Therapy. 9: 737-46. PMID 12189523 DOI: 10.1038/Sj.Cgt.7700490  1
2002 Hanenberg H, Batish SD, Pollok KE, Vieten L, Verlander PC, Leurs C, Cooper RJ, Göttsche K, Haneline L, Clapp DW, Lobitz S, Williams DA, Auerbach AD. Phenotypic correction of primary Fanconi anemia T cells with retroviral vectors as a diagnostic tool. Experimental Hematology. 30: 410-20. PMID 12031647 DOI: 10.1016/S0301-472X(02)00782-8  1
2002 Worthington RA, Smart ML, Gu BJ, Williams DA, Petrou S, Wiley JS, Barden JA. Point mutations confer loss of ATP-induced human P2X(7) receptor function. Febs Letters. 512: 43-6. PMID 11852049 DOI: 10.1016/S0014-5793(01)03311-7  1
2001 Pollok KE, van Der Loo JC, Cooper RJ, Hartwell JR, Miles KR, Breese R, Williams EP, Montel A, Seshadri R, Hanenberg H, Williams DA. Differential transduction efficiency of SCID-repopulating cells derived from umbilical cord blood and granulocyte colony-stimulating factor-mobilized peripheral blood. Human Gene Therapy. 12: 2095-108. PMID 11747599 DOI: 10.1089/10430340152677430  1
2001 Williams DA. Inflammatory cytokines and mucosal injury Journal of the National Cancer Institute. Monographs. 26-30. PMID 11694562 DOI: 10.1093/Oxfordjournals.Jncimonographs.A003435  1
2001 Ingram DA, Hiatt K, King AJ, Fisher L, Shivakumar R, Derstine C, Wenning MJ, Diaz B, Travers JB, Hood A, Marshall M, Williams DA, Clapp DW. Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro. The Journal of Experimental Medicine. 194: 57-69. PMID 11435472 DOI: 10.1084/Jem.194.1.57  1
2001 Schmidt M, Hoffmann G, Wissler M, Lemke N, Müssig A, Glimm H, Williams DA, Ragg S, Hesemann CU, von Kalle C. Detection and direct genomic sequencing of multiple rare unknown flanking DNA in highly complex samples. Human Gene Therapy. 12: 743-9. PMID 11339891 DOI: 10.1089/104303401750148649  1
2001 Yang FC, Atkinson SJ, Gu Y, Borneo JB, Roberts AW, Zheng Y, Pennington J, Williams DA. Rac and Cdc42 GTPases control hematopoietic stem cell shape, adhesion, migration, and mobilization Proceedings of the National Academy of Sciences of the United States of America. 98: 5614-5618. PMID 11320224 DOI: 10.1073/Pnas.101546898  1
2001 Gu Y, Jia B, Yang FC, D'Souza M, Harris CE, Derrow CW, Zheng Y, Williams DA. Biochemical and biological characterization of a human Rac2 GTPase mutant associated with phagocytic immunodeficiency. The Journal of Biological Chemistry. 276: 15929-38. PMID 11278678 DOI: 10.1074/Jbc.M010445200  1
2000 Abonour R, Williams DA, Einhorn L, Hall KM, Chen J, Coffman J, Traycoff CM, Bank A, Kato I, Ward M, Williams SD, Hromas R, Robertson MJ, Smith FO, Woo D, et al. Efficient retrovirus-mediated transfer of the multidrug resistance 1 gene into autologous human long-term repopulating hematopoietic stem cells. Nature Medicine. 6: 652-8. PMID 10835681 DOI: 10.1038/76225  1
2000 Woods EJ, Liu J, Derrow CW, Smith FO, Williams DA, Critser JK. Osmometric and permeability characteristics of human placental/umbilical cord blood CD34+ cells and their application to cryopreservation Journal of Hematotherapy and Stem Cell Research. 9: 161-173. PMID 10813529 DOI: 10.1089/152581600319379  1
2000 Narayanan R, LeDuc B, Williams DA. Determination of the kinetics of rat UDP-glucuronosyltransferases (UGTs) in liver and intestine using HPLC Journal of Pharmaceutical and Biomedical Analysis. 22: 527-540. PMID 10766370 DOI: 10.1016/S0731-7085(00)00241-7  1
2000 Melgarejo T, Williams DA, O'Connell NC, Setchell KDR. Serum unconjugated bile acids as a test for intestinal bacterial overgrowth in dogs Digestive Diseases and Sciences. 45: 407-414. PMID 10711460 DOI: 10.1023/A:1005493416946  1
2000 Ingram DA, Yang FC, Travers JB, Wenning MJ, Hiatt K, New S, Hood A, Shannon K, Williams DA, Clapp DW. Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo Journal of Experimental Medicine. 191: 181-187. PMID 10620616 DOI: 10.1084/Jem.191.1.181  1
2000 Williams DA, Tao W, Yang F, Kim C, Gu Y, Mansfield P, Levine JE, Petryniak B, Derrow CW, Harris C, Jia B, Zheng Y, Ambruso DR, Lowe JB, Atkinson SJ, et al. Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency Blood. 96: 1646-1654. DOI: 10.1182/Blood.V96.5.1646.H8001646_1646_1654  1
1999 Grosfeld JL, Du X, Williams DA. Interleukin-11: its biology and prospects for clinical use. Jpen. Journal of Parenteral and Enteral Nutrition. 23: S67-9. PMID 10483899 DOI: 10.1177/014860719902300517  1
1999 Campbell SP, Williams DA, Frueh BR, Lynch GS. Contractile activation characteristics of single permeabilized fibres from levator palpebrae superioris, orbicularis oculi and vastus lateralis muscles from humans Journal of Physiology. 519: 615-622. PMID 10457076 DOI: 10.1111/J.1469-7793.1999.0615M.X  1
1999 Williams DA. Retroviral-fibronectin interactions in transduction of mammalian cells Annals of the New York Academy of Sciences. 872: 109-114. PMID 10372115 DOI: 10.1111/J.1749-6632.1999.Tb08457.X  1
1999 Sellers SE, Tisdale JF, Bodine DM, Williams DA, Karlsson S, Meztger M, Donahue RE, Dunbar CE. No discrepancy between in vivo gene marking efficiency assessed in peripheral blood populations compared with bone marrow progenitors or CD34+ cells Human Gene Therapy. 10: 633-640. PMID 10094206 DOI: 10.1089/10430349950018706  1
1999 Roberts AW, Kim C, Zhen L, Lowe JB, Kapur R, Petryniak B, Spaetti A, Pollock JD, Borneo JB, Bradford GB, Atkinson SJ, Dinauer MC, Williams DA. Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense. Immunity. 10: 183-96. PMID 10072071 DOI: 10.1016/S1074-7613(00)80019-9  1
1998 Travers JB, Murphy RC, Johnson CA, Pei Y, Morin SM, Clay KL, Barber LA, Hood AF, Morelli JG, Williams DA. Identification and pharmacological characterization of platelet-activating factor and related 1-palmitoyl species in human inflammatory blistering diseases. Prostaglandins & Other Lipid Mediators. 56: 305-24. PMID 9990675 DOI: 10.1016/S0090-6980(98)00060-4  1
1998 Edwards LJ, Williams DA, Gardner DK. Intracellular pH of the mouse preimplantation embryo: Amino acids act as buffers of intracellular pH Human Reproduction. 13: 3441-3448. PMID 9886531 DOI: 10.1093/Humrep/13.12.3441  1
1998 Edwards LJ, Williams DA, Gardner DK. Intracellular pH of the preimplantation mouse embryo: Effects of extracellular pH and weak acids Molecular Reproduction and Development. 50: 434-442. PMID 9669527 DOI: 10.1002/(Sici)1098-2795(199808)50:4<434::Aid-Mrd7>3.0.Co;2-J  1
1998 Menkes DL, Hood DC, Ballesteros RA, Williams DA. Root stimulation improves the detection of acquired demyelinating polyneuropathies. Muscle & Nerve. 21: 298-308. PMID 9486858 DOI: 10.1002/(SICI)1097-4598(199803)21:3<298::AID-MUS3>3.0.CO;2-5  1
1998 Fiore NF, Ledniczky G, Liu Q, Orazi A, Du X, Williams DA, Grosfeld JL. Comparison of interleukin-11 and epidermal growth factor on residual small intestine after massive small bowel resection. Journal of Pediatric Surgery. 33: 24-9. PMID 9473093 DOI: 10.1016/S0022-3468(98)90354-2  1
1998 Hansen WK, Deutsch WA, Yacoub A, Xu Y, Williams DA, Kelley MR. Creation of a fully functional human chimeric DNA repair protein. Combining O6-methylguanine DNA methyltransferase (MGMT) and AP endonuclease (APE/redox effector factor 1 (Ref 1)) DNA repair proteins. The Journal of Biological Chemistry. 273: 756-62. PMID 9422728 DOI: 10.1074/Jbc.273.2.756  1
1997 Trello CA, Williams DA, Keller CA, Crim C, Webster RO, Ohar JA. Increased gelatinolytic activity in bronchoalveolar lavage fluid in stable lung transplant recipients American Journal of Respiratory and Critical Care Medicine. 156: 1978-1986. PMID 9412583 DOI: 10.1164/ajrccm.156.6.9704044  1
1997 Irwin DJ, Miller JM, Milner PC, Patterson T, Richards RG, Williams DA, Insley CA, Stuart JM. Community immunization programme in response to an outbreak of invasive Neisseria meningitidis serogroup C infection in the Trent region of England 1995-1996. Journal of Public Health Medicine. 19: 162-70. PMID 9243431 DOI: 10.1093/oxfordjournals.pubmed.a024604  1
1997 Hayes A, Williams DA. Contractile properties of clenbuterol-treated MDX muscle are enhanced by low-intensity swimming Journal of Applied Physiology. 82: 435-439. PMID 9049721 DOI: 10.1152/Jappl.1997.82.2.435  1
1996 Larochelle A, Vormoor J, Hanenberg H, Wang JCY, Bhatia M, Lapidot T, Moritz T, Murdoch B, Xiao XL, Kato I, Williams DA, Dick JE. Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: Implications for gene therapy Nature Medicine. 2: 1329-1337. PMID 8946831 DOI: 10.1038/Nm1296-1329  1
1996 Lynch GS, Hayes A, Campbell SP, Williams DA. Effects of β2-agonist administration and exercise on contractile activation of skeletal muscle fibers Journal of Applied Physiology. 81: 1610-1618. PMID 8904577 DOI: 10.1152/Jappl.1996.81.4.1610  1
1995 Lynch GS, Duncan ND, Campbell SP, Williams DA. Endurance training effects on the contractile activation characteristics of single muscle fibres from the rat diaphragm Clinical and Experimental Pharmacology and Physiology. 22: 430-437. PMID 8582094 DOI: 10.1111/J.1440-1681.1995.Tb02035.X  1
1995 Lynch GS, Stephenson DG, Williams DA. Analysis of Ca2+ and Sr2+ activation characteristics in skinned muscle fibre preparations with different proportions of myofibrillar isoforms Journal of Muscle Research and Cell Motility. 16: 65-78. PMID 7751406 DOI: 10.1007/BF00125311  1
1993 Williams DA, Head SI, Lynch GS, Stephenson DG. Contractile properties of skinned muscle fibres from young and adult normal and dystrophic (mdx) mice. The Journal of Physiology. 460: 51-67. PMID 8487206 DOI: 10.1113/jphysiol.1993.sp019458  1
1993 Bakker AJ, Head SI, Williams DA, Stephenson DG. Ca2+ levels in myotubes grown from the skeletal muscle of dystrophic (mdx) and normal mice. The Journal of Physiology. 460: 1-13. PMID 8487190 DOI: 10.1113/Jphysiol.1993.Sp019455  1
1993 Lynch GS, Stephenson DG, Williams DA. Muscle samples obtained by needle biopsy are suitable for studying single fibre contractile properties. Acta Physiologica Scandinavica. 148: 27-35. PMID 8333294 DOI: 10.1111/j.1748-1716.1993.tb09528.x  1
1993 Williams DA. Mechanisms of calcium release and propagation in cardiac cells. Do studies with confocal microscopy add to our understanding? Cell Calcium. 14: 724-735. PMID 8131189 DOI: 10.1016/0143-4160(93)90098-Q  1
1993 Bodine DM, Moritz T, Donahue RE, Luskey BD, Kessler SW, Martin DI, Orkin SH, Nienhuis AW, Williams DA. Long-term in vivo expression of a murine adenosine deaminase gene in rhesus monkey hematopoietic cells of multiple lineages after retroviral mediated gene transfer into CD34+ bone marrow cells. Blood. 82: 1975-80. PMID 7691243 DOI: 10.1182/Blood.V82.7.1975.Bloodjournal8271975  1
1992 Head SI, Williams DA, Stephenson DG. Abnormalities in structure and function of limb skeletal muscle fibres of dystrophic mdx mice. Proceedings. Biological Sciences / the Royal Society. 248: 163-9. PMID 1352891 DOI: 10.1098/rspb.1992.0058  1
1992 Sieff CA, Yokoyama CT, Zsebo KM, Trammell J, Andersen JW, Nathan DG, Williams DA. The production of steel factor mRNA in Diamond-Blackfan anaemia long-term cultures and interactions of steel factor with erythropoietin and interleukin-3. British Journal of Haematology. 82: 640-7. PMID 1282827 DOI: 10.1111/J.1365-2141.1992.Tb06938.X  1
1991 Lynch GS, Stephenson DG, Williams DA. Endurance exercise effects on the contractile properties of single, skinned skeletal muscle fibres of young rats PflüGers Archiv European Journal of Physiology. 418: 161-167. PMID 2041719 DOI: 10.1007/BF00370466  1
1991 Wilson GJ, Dos Remedios CG, Stephenson DG, Williams DA. Effects of sulphydryl modification on skinned rat skeletal muscle fibers using 5,5'-dithiobis(2-nitrobenzoic acid) Journal of Physiology. 437: 409-430. PMID 1890642 DOI: 10.1113/Jphysiol.1991.Sp018603  1
1991 Skalnik DG, Dorfman DM, Williams DA, Orkin SH. Restriction of neuroblastoma to the prostate gland in transgenic mice Molecular and Cellular Biology. 11: 4518-4527. PMID 1652058 DOI: 10.1128/Mcb.11.9.4518  1
1990 Head SI, Stephenson DG, Williams DA. Properties of enzymatically isolated skeletal fibres from mice with muscular dystrophy Journal of Physiology. 422: 351-367. PMID 2352184 DOI: 10.1113/Jphysiol.1990.Sp017988  1
1990 Fink RHA, Stephenson DG, Williams DA. Physiological properties of skinned fibres from normal and dystrophic (Duchenne) human muscle activated by Ca2+ and Sr2+ Journal of Physiology. 420: 337-353. PMID 2324989 DOI: 10.1113/Jphysiol.1990.Sp017916  1
1990 Williams DA. Quantitative intracellular calcium imaging with laser-scanning confocal microscopy Cell Calcium. 11: 589-597. PMID 2285927 DOI: 10.1016/0143-4160(90)90013-K  1
1990 Williams DA, Head SI, Bakker AJ, Stephenson DG. Resting calcium concentrations in isolated skeletal muscle fibres of dystrophic mice Journal of Physiology. 428: 243-256. PMID 2231412 DOI: 10.1113/Jphysiol.1990.Sp018210  1
1990 Moore EDW, Becker PL, Fogarty KE, Williams DA, Fay FS. Ca2+ imaging in single living cells: Theoretical and practical issues Cell Calcium. 11: 157-179. PMID 2191780 DOI: 10.1016/0143-4160(90)90068-6  1
1989 Lim B, Apperley JF, Orkin SH, Williams DA. Long-term expression of human adenosine deaminase in mice transplanted with retrovirus-infected hematopoietic stem cells Proceedings of the National Academy of Sciences of the United States of America. 86: 8892-8896. PMID 2573068 DOI: 10.1073/Pnas.86.22.8892  1
1988 Kenney WL, Lewis DA, Armstrong CG, Hyde DE, Dyksterhouse TS, Fowler SR, Williams DA. Psychrometric limits to prolonged work in protective clothing ensembles. American Industrial Hygiene Association Journal. 49: 390-5. PMID 3177217 DOI: 10.1080/15298668891379954  1
1988 Williams DA, Rosenblatt MF, Beier DR, Cone RD. Generation of murine stromal cell lines supporting hematopoietic stem cell proliferation by use of recombinant retrovirus vectors encoding simian virus 40 large T antigen. Molecular and Cellular Biology. 8: 3864-71. PMID 2851729 DOI: 10.1128/Mcb.8.9.3864  0.32
1987 Lim B, Williams DA, Orkin SH. Retrovirus-mediated gene transfer of human adenosine deaminase: expression of functional enzyme in murine hematopoietic stem cells in vivo Molecular and Cellular Biology. 7: 3459-3465. PMID 3683389 DOI: 10.1128/Mcb.7.10.3459  1
1987 Kenney WL, Lewis DA, Hyde DE, Dyksterhouse TS, Armstrong CG, Fowler SR, Williams DA. Physiologically derived critical evaporative coefficients for protective clothing ensembles. Journal of Applied Physiology (Bethesda, Md. : 1985). 63: 1095-9. PMID 3654457 DOI: 10.1152/jappl.1987.63.3.1095  1
1987 Williams DA, Hsieh K, DeSilva A, Mulligan RC. Protection of bone marrow transplant recipients from lethal doses of methotrexate by the generation of methotrexate-resistant bone marrow. The Journal of Experimental Medicine. 166: 210-8. PMID 3298524 DOI: 10.1084/Jem.166.1.210  1
1986 Fink RH, Stephenson DG, Williams DA. Calcium and strontium activation of single skinned muscle fibres of normal and dystrophic mice The Journal of Physiology. 373: 513-525. PMID 3746681 DOI: 10.1113/Jphysiol.1986.Sp016060  1
1986 Williams DA, Orkin SH. Somatic gene therapy. Current status and future prospects Journal of Clinical Investigation. 77: 1053-1056. PMID 3514670 DOI: 10.1172/Jci112403  1
1986 Williams DA, Orkin SH, Mulligan RC. Retrovirus-mediated transfer of human adenosine deaminase gene sequences into cells in culture and into murine hematopoietic cells in vivo. Proceedings of the National Academy of Sciences of the United States of America. 83: 2566-70. PMID 3458218 DOI: 10.1073/Pnas.83.8.2566  1
1986 Fink RH, Stephenson DG, Williams DA. Potassium and ionic strength effects on the isometric force of skinned twitch muscle fibres of the rat and toad The Journal of Physiology. 370: 317-337. PMID 3083099 DOI: 10.1113/jphysiol.1986.sp015937  1
1985 Williams DA, Fogarty KE, Tsien RY, Fay FS. Calcium gradients in single smooth muscle cells revealed by the digital imaging microscope using Fura-2 Nature. 318: 558-561. PMID 3934562 DOI: 10.1038/318558A0  1
1985 Stephenson DG, Williams DA. Temperature‐dependent calcium sensitivity changes in skinned muscle fibres of rat and toad The Journal of Physiology. 360: 1-12. PMID 3921690 DOI: 10.1113/Jphysiol.1985.Sp015600  1
1984 Williams DA. Serum isoamylases and canine pancreatic insufficiency Veterinary Record. 115: 334. PMID 6495597 DOI: 10.1136/vr.115.13.334-a  1
1984 Williams DA, Lemischka IR, Nathan DG, Mulligan RC. Introduction of new genetic material into pluripotent haematopoietic stem cells of the mouse. Nature. 310: 476-80. PMID 6087158 DOI: 10.1038/310476A0  1
1983 Stephenson DG, Williams DA. Slow amphibian muscle fibres become less sensitive to Ca2+ with increasing sarcomere length PflüGers Archiv European Journal of Physiology. 397: 248-250. PMID 6410354 DOI: 10.1007/Bf00584366  1
1982 Stephenson DG, Williams DA. Effects of sarcomere length on the force-pCa relation in fast- and slow-twitch skinned muscle fibres from the rat Journal of Physiology. 637-653. PMID 7182478 DOI: 10.1113/Jphysiol.1982.Sp014473  1
1981 Stephenson DG, Williams DA. Calcium-activated force responses in fast- and slow-twitch skinned muscle fibres of the rat at different temperatures Journal of Physiology. 281-302. PMID 7310735 DOI: 10.1113/Jphysiol.1981.Sp013825  1
1980 Stephenson DG, Williams DA. Activation of skinned arthropod muscle fibres by Ca2+ and Sr2+ Journal of Muscle Research and Cell Motility. 1: 73-87. PMID 7229023 DOI: 10.1007/Bf00711926  1
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