David A. Williams, MD - Publications

Boston Children's Hospital, Harvard Boston Children's Hospital, Harvard 

224 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Zhu J, Eichler F, Biffi A, Duncan CN, Williams DA, Majzoub JA. The Changing Face of Adrenoleukodystrophy. Endocrine Reviews. PMID 32364223 DOI: 10.1210/Endrev/Bnaa013  0.304
2020 Brendel C, Negre O, Rothe M, Guda S, Parsons G, Harris C, McGuinness M, Abriss D, Tsytsykova A, Klatt D, Bentler M, Pellin D, Christiansen L, Schambach A, Manis J, ... ... Williams DA, et al. Preclinical Evaluation of a Novel Lentiviral Vector Driving Lineage-Specific BCL11A Knockdown for Sickle Cell Gene Therapy. Molecular Therapy. Methods & Clinical Development. 17: 589-600. PMID 32300607 DOI: 10.1016/J.Omtm.2020.03.015  0.351
2020 Kohn DB, Booth C, Kang EM, Pai SY, Shaw KL, Santilli G, Armant M, Buckland KF, Choi U, De Ravin SS, Dorsey MJ, Kuo CY, Leon-Rico D, Rivat C, Izotova N, ... ... Williams DA, et al. Lentiviral gene therapy for X-linked chronic granulomatous disease. Nature Medicine. PMID 31988463 DOI: 10.1038/S41591-019-0735-5  0.338
2020 Walters MC, Locatelli F, Thrasher AJ, Tisdale JF, Orchard PJ, Duncan CN, Kühl J, De Oliveira SN, Sauer MG, Kulozik AE, Yannaki E, Hongeng S, Mapara MY, Krishnamurti L, Hermine O, ... ... Williams DA, et al. Safety of Autologous Hematopoietic Stem Cell Transplantation with Gene Addition Therapy for Transfusion-Dependent β-Thalassemia, Sickle Cell Disease, and Cerebral Adrenoleukodystrophy Biology of Blood and Marrow Transplantation. 26: S38-S39. DOI: 10.1016/J.Bbmt.2019.12.104  0.34
2020 Orchard PJ, Eichler F, Duncan C, De Oliveira S, Thrasher AJ, Kühl J, Lund TC, Sevin C, Gissen P, Amartino H, Smith NJ, Shamir E, Chin W, McNeil E, Aubourg P, ... Williams DA, et al. Lenti-D Hematopoietic Stem Cell Gene Therapy Stabilizes Neurologic Function in Boys with Cerebral Adrenoleukodystrophy Biology of Blood and Marrow Transplantation. 26: S37-S38. DOI: 10.1016/J.Bbmt.2019.12.103  0.307
2019 Curran KJ, Margossian S, Kernan NA, Silverman LB, Williams DA, Shukla NN, Kobos R, Forlenza C, Steinherz P, Prockop S, Boulad F, Spitzer B, Cancio MI, Boelens JJ, Kung AL, et al. Toxicity and Response following CD19-specific CAR T cells in pediatric/young adult relapsed/refractory B-ALL. Blood. PMID 31650176 DOI: 10.1182/Blood.2019001641  0.496
2019 Hu T, Chong Y, Lu S, McGuinness M, Williams DA, Cowell JK. RAC1/2 activation promotes FGFR1 driven leukemogenesis in stem cell leukemia/lymphoma syndrome. Haematologica. PMID 31221776 DOI: 10.3324/Haematol.2018.208058  0.3
2019 Wu Y, Zeng J, Roscoe BP, Liu P, Yao Q, Lazzarotto CR, Clement K, Cole MA, Luk K, Baricordi C, Shen AH, Ren C, Esrick EB, Manis JP, Dorfman DM, ... Williams DA, et al. Highly efficient therapeutic gene editing of human hematopoietic stem cells. Nature Medicine. PMID 30911135 DOI: 10.1038/S41591-019-0401-Y  0.348
2019 Esrick EB, Achebe M, Armant M, Bartolucci P, Ciuculescu MF, Daley H, Dansereau C, Di Caprio G, Goncalves B, Hebert N, Heeney MM, Higgins JM, Lehmann LE, Manis JP, Negre O, ... ... Williams DA, et al. Validation of BCL11A As Therapeutic Target in Sickle Cell Disease: Results from the Adult Cohort of a Pilot/Feasibility Gene Therapy Trial Inducing Sustained Expression of Fetal Hemoglobin Using Post-Transcriptional Gene Silencing Blood. 134: LBA-5-LBA-5. DOI: 10.1182/Blood-2019-132745  0.326
2019 Labrosse R, Chu J, Armant M, Spek Jvd, Miggelbrink A, Fong J, Everett JK, Raymond H, Kessler L, Dansereau C, Mackinnon B, Koo S, Morris E, London WB, Ozen A, ... ... Williams DA, et al. Outcome of Hematopoietic Stem Cell Gene Therapy for Wiskott-Aldrich Syndrome Blood. 134: 4629-4629. DOI: 10.1182/Blood-2019-126161  0.307
2019 Duncan C, Eichler F, Thrasher AJ, Orchard PJ, De Oliveira SN, Lund TC, Amartino H, Smith NJ, McNeil E, Chin W, Aubourg P, Williams DA. Updated Safety and Efficacy Outcomes from an Ongoing Phase 2/3 Trial of Lenti-D Autologous Hematopoietic Stem Cell Gene Therapy for the Treatment of Cerebral Adrenoleukodystrophy Biology of Blood and Marrow Transplantation. 25: S89-S90. DOI: 10.1016/J.Bbmt.2018.12.169  0.319
2018 Esrick EB, Manis JP, Daley H, Baricordi C, Trébéden-Negre H, Pierciey FJ, Armant M, Nikiforow S, Heeney MM, London WB, Biasco L, Asmal M, Williams DA, Biffi A. Successful hematopoietic stem cell mobilization and apheresis collection using plerixafor alone in sickle cell patients. Blood Advances. 2: 2505-2512. PMID 30282642 DOI: 10.1182/Bloodadvances.2018016725  0.335
2018 Clarke EL, Connell AJ, Six E, Kadry NA, Abbas AA, Hwang Y, Everett JK, Hofstaedter CE, Marsh R, Armant M, Kelsen J, Notarangelo LD, Collman RG, Hacein-Bey-Abina S, Kohn DB, ... ... Williams DA, et al. T cell dynamics and response of the microbiota after gene therapy to treat X-linked severe combined immunodeficiency. Genome Medicine. 10: 70. PMID 30261899 DOI: 10.1186/S13073-018-0580-Z  0.309
2018 Zeng J, Bauer DE, Wu Y, Roscoe BP, Liu P, Yao Q, Lazzarrotto C, Clement MK, Cole MA, Luk K, Baricordi C, Esrick EB, Manis JP, Dorfma D, Williams DA, et al. Highly Efficient Therapeutic Gene Editing of BCL11A enhancer in Human Hematopoietic Stem Cells from ß-Hemoglobinopathy Patients for Fetal Hemoglobin Induction Blood. 132: 3482-3482. DOI: 10.1182/Blood-2018-99-119365  0.333
2018 Esrick EB, Brendel C, Manis JP, Armant MA, Negre H, Dansereau C, Ciuculescu MF, Patriarca S, Mackinnon B, Daley H, Richard S, Abriss D, Maxwell R, Braunewell S, Christiansen L, ... ... Williams DA, et al. Flipping the Switch: Initial Results of Genetic Targeting of the Fetal to Adult Globin Switch in Sickle Cell Patients Blood. 132: 1023-1023. DOI: 10.1182/Blood-2018-99-116733  0.358
2018 McCabe A, Brendel C, Frei S, Klatt D, Bentler M, Snapper S, Williams DA. Interleukin-10 Signaling in Hematopoietic Stem and Progenitor Cells Maintains Stem Cell Function and Regulates Inflammation-Induced Myeloid Cell Output Blood. 132: 2407-2407. DOI: 10.1182/Blood-2018-99-116168  0.325
2018 Renella R, Gagne K, Beauchamp E, Schlaeger T, Hofmann I, Shimamura A, Fogel J, Agarwal S, Ebert BL, Markianos K, Springer TA, Fleming MD, Williams DA. Congenital X-Linked Myelodysplasia with Tetraploidy Is Associated with De Novo Germline C-Terminal Mutation of SEPT6, a Septin Filament Protein Blood. 132: 644-644. DOI: 10.1182/Blood-2018-99-114682  0.336
2018 Duncan C, Eichler F, Musolino PL, Orchard PJ, De Oliveira S, Thrasher AJ, Armant MA, Dansereau C, Lund TC, Miller WP, Raymond GV, Sankar R, Shah AJ, Sevin C, Gaspar HB, ... ... Williams DA, et al. Lenti-D Hematopoietic Stem Cell Gene Therapy to Arrest Progression of Cerebral Adrenoleukodystrophy: Interim Results of an International Phase 2/3 Trial Biology of Blood and Marrow Transplantation. 24: S73-S74. DOI: 10.1016/J.Bbmt.2017.12.642  0.3
2017 Eichler F, Duncan C, Musolino PL, Orchard PJ, De Oliveira S, Thrasher AJ, Armant M, Dansereau C, Lund TC, Miller WP, Raymond GV, Sankar R, Shah AJ, Sevin C, Gaspar HB, ... ... Williams DA, et al. Hematopoietic Stem-Cell Gene Therapy for Cerebral Adrenoleukodystrophy. The New England Journal of Medicine. PMID 28976817 DOI: 10.1056/Nejmoa1700554  0.334
2017 Alonso-Ferrero ME, van Til NP, Bartolovic K, Mata MF, Wagemaker G, Moulding D, Williams DA, Kinnon C, Waddington SN, Milsom MD, Howe SJ. Enhancement of mouse hematopoietic stem/progenitor cell function via transient gene delivery using integration-deficient lentiviral vectors. Experimental Hematology. PMID 28911908 DOI: 10.1016/J.Exphem.2017.09.003  0.349
2017 Thrasher AJ, Williams DA. Evolving Gene Therapy in Primary Immunodeficiency. Molecular Therapy : the Journal of the American Society of Gene Therapy. 25: 1132-1141. PMID 28366768 DOI: 10.1016/J.Ymthe.2017.03.018  0.323
2016 Brendel C, Guda S, Renella R, Bauer DE, Canver MC, Kim YJ, Heeney MM, Klatt D, Fogel J, Milsom MD, Orkin SH, Gregory RI, Williams DA. Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype. The Journal of Clinical Investigation. 126: 3868-3878. PMID 27599293 DOI: 10.1172/Jci87885  0.354
2016 Mino A, Troeger A, Brendel C, Cantor A, Harris C, Ciuculescu MF, Williams DA. RhoH participates in a multi-protein complex with the zinc finger protein kaiso that regulates both cytoskeletal structures and chemokine-induced T cells. Small Gtpases. 1-14. PMID 27574848 DOI: 10.1080/21541248.2016.1220780  0.308
2016 Altrock PM, Brendel C, Renella R, Orkin SH, Williams DA, Michor F. Mathematical modeling of erythrocyte chimerism informs genetic intervention strategies for sickle cell disease. American Journal of Hematology. 91: 931-7. PMID 27299299 DOI: 10.1002/Ajh.24449  0.345
2016 Poletti V, Charrier S, Martin S, Gjata B, Vignaud A, Zhang F, Buckland K, Rothe M, Schambach A, Pai S, Williams DA, Gaspar HB, Thrasher AJ, Mavilio F. Preclinical Development of Gene Therapy for X-Linked Severe Combined Immunodeficiency (SCID-X1) Blood. 128: 4705-4705. DOI: 10.1182/Blood.V128.22.4705.4705  0.371
2016 De Vita S, Li Y, Harris CE, McGuinness M, Williams DA. Vav1, a Rho GTPase Guanine Exchange Factor (GEF) Is Required to Integrate gp130 Cytokine Signaling for Successful Engraftment of Murine Hematopoietic Stem Cells Following Irradiation Blood. 128: 2149-2149. DOI: 10.1182/Blood.V128.22.2149.2149  0.341
2016 Altrock PM, Brendel C, Renella R, Orkin SH, Williams DA, Michor F. 314. Mathematical Modeling of Erythrocyte Chimerism Informs Clinical Strategies for Sickle Cell Disease Molecular Therapy. 24: S126-S127. DOI: 10.1016/S1525-0016(16)33123-9  0.338
2016 Brendel C, Guda S, Renella R, Bauer DE, Canver MC, Kim Y, Heeney MM, Klatt D, Fogel J, Milsom MD, Orkin SH, Gregory RI, Williams DA. 282. Circumventing Hematopoietic Toxicities and Reversing Sickle Phenotype by Lineage-Specific BCL11A Knock Down and γ-Globin Induction Molecular Therapy. 24: S113. DOI: 10.1016/S1525-0016(16)33091-X  0.37
2015 Ciuculescu MF, Park SY, Canty K, Mathieu R, Silberstein LE, Williams DA. Perivascular deletion of murine Rac reverses the ratio of marrow arterioles and sinusoid vessels and alters hematopoiesis in vivo. Blood. 125: 3105-13. PMID 25824687 DOI: 10.1182/Blood-2014-10-604892  0.368
2015 Walter D, Lier A, Geiselhart A, Thalheimer FB, Huntscha S, Sobotta MC, Moehrle B, Brocks D, Bayindir I, Kaschutnig P, Muedder K, Klein C, Jauch A, Schroeder T, Geiger H, ... ... Williams DA, et al. Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells. Nature. 520: 549-52. PMID 25707806 DOI: 10.1038/Nature14131  0.346
2015 Forester CM, Sartain SE, Guo D, Harris MH, Weinberg OK, Fleming MD, London WB, Williams DA, Hofmann I. Pediatric aplastic anemia and refractory cytopenia: A retrospective analysis assessing outcomes and histomorphologic predictors. American Journal of Hematology. 90: 320-6. PMID 25580823 DOI: 10.1002/Ajh.23937  0.308
2015 Zhang MY, Keel SB, Walsh T, Lee MK, Gulsuner S, Watts AC, Pritchard CC, Salipante SJ, Jeng MR, Hofmann I, Williams DA, Fleming MD, Abkowitz JL, King MC, Shimamura A. Genomic analysis of bone marrow failure and myelodysplastic syndromes reveals phenotypic and diagnostic complexity. Haematologica. 100: 42-8. PMID 25239263 DOI: 10.3324/Haematol.2014.113456  0.329
2015 Chu JI, Henderson LA, Armant M, Male F, Dansereau CH, MacKinnon B, Burke CJ, Cavanaugh ME, London WB, Barlan IB, Özen A, Baris S, Karakoc-Aydiner E, Kiykim A, Hanson IC, ... ... Williams DA, et al. Gene Therapy Using a Self-Inactivating Lentiviral Vector Improves Clinical and Laboratory Manifestations of Wiskott-Aldrich Syndrome Blood. 126: 260-260. DOI: 10.1182/Blood.V126.23.260.260  0.361
2014 Bruedigam C, Bagger FO, Heidel FH, Paine Kuhn C, Guignes S, Song A, Austin R, Vu T, Lee E, Riyat S, Moore AS, Lock RB, Bullinger L, Hill GR, Armstrong SA, ... Williams DA, et al. Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy. Cell Stem Cell. 15: 775-90. PMID 25479751 DOI: 10.1016/J.Stem.2014.11.010  0.337
2014 Lane SW, Williams DA, Watt FM. Modulating the stem cell niche for tissue regeneration. Nature Biotechnology. 32: 795-803. PMID 25093887 DOI: 10.1038/Nbt.2978  0.338
2014 Ciuculescu MF, Brendel C, Harris CE, Williams DA. Retroviral transduction of murine and human hematopoietic progenitors and stem cells. Methods in Molecular Biology (Clifton, N.J.). 1185: 287-309. PMID 25062637 DOI: 10.1007/978-1-4939-1133-2_20  0.397
2014 Gordon PM, Dias S, Williams DA. Cytokines secreted by bone marrow stromal cells protect c-KIT mutant AML cells from c-KIT inhibitor-induced apoptosis. Leukemia. 28: 2257-60. PMID 25030047 DOI: 10.1038/Leu.2014.212  0.328
2014 De Vita S, Schneider RK, Garcia M, Wood J, Gavillet M, Ebert BL, Gerbaulet A, Roers A, Levine RL, Mullally A, Williams DA. Loss of function of TET2 cooperates with constitutively active KIT in murine and human models of mastocytosis. Plos One. 9: e96209. PMID 24788138 DOI: 10.1371/Journal.Pone.0096209  0.32
2014 Williams DA, Thrasher AJ. Concise review: lessons learned from clinical trials of gene therapy in monogenic immunodeficiency diseases. Stem Cells Translational Medicine. 3: 636-42. PMID 24682287 DOI: 10.5966/Sctm.2013-0206  0.3
2014 Rose SR, Kim MO, Korbee L, Wilson KA, Ris MD, Eyal O, Sherafat-Kazemzadeh R, Bollepalli S, Harris R, Jeng MR, Williams DA, Smith FO. Oxandrolone for the treatment of bone marrow failure in Fanconi anemia. Pediatric Blood & Cancer. 61: 11-9. PMID 24019220 DOI: 10.1002/Pbc.24617  0.332
2014 Troeger A, Wood J, Williams DA. Investigation of T Cell Subsets and Germinal Center Reaction in a B Cell Malignancy Model of Mice Deficient in the Lymphoma Hyermutable Gene Rhoh Blood. 124: 3294-3294. DOI: 10.1182/Blood.V124.21.3294.3294  0.336
2014 Geiselhart A, Walter D, Lier A, Thalheimer FB, Huntscha S, Brocks D, Bayindir I, Kaschutnig P, Müdder K, Sobotta M, Dick T, Holland-Letz T, Schmezer P, Schröder T, Lane SW, ... ... Williams DA, et al. Altered HSC Metabolism in Response to Stress Leads to De Novo dna Damage and Cellular Attrition Blood. 124: 255-255. DOI: 10.1182/Blood.V124.21.255.255  0.303
2013 Williams DA. Broadening the indications for hematopoietic stem cell genetic therapies. Cell Stem Cell. 13: 263-4. PMID 24012366 DOI: 10.1016/J.Stem.2013.08.006  0.323
2013 Pannucci NL, Li D, Sahay S, Thomas EK, Chen R, Tala I, Hu T, Ciccarelli BT, Megjugorac NJ, Adams Iii HC, Rodriguez PL, Fitzpatrick ER, Lagunoff D, Williams DA, Whitehead IP. Loss of the xeroderma pigmentosum group B protein binding site impairs p210 BCR/ABL1 leukemogenic activity. Blood Cancer Journal. 3: e135. PMID 23955590 DOI: 10.1038/Bcj.2013.36  0.328
2013 Mullally A, Bruedigam C, Poveromo L, Heidel FH, Purdon A, Vu T, Austin R, Heckl D, Breyfogle LJ, Kuhn CP, Kalaitzidis D, Armstrong SA, Williams DA, Hill GR, Ebert BL, et al. Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-α in a murine model of polycythemia vera. Blood. 121: 3692-702. PMID 23487027 DOI: 10.1182/Blood-2012-05-432989  0.355
2013 Dorrance AM, De Vita S, Radu M, Reddy PN, McGuinness MK, Harris CE, Mathieu R, Lane SW, Kosoff R, Milsom MD, Chernoff J, Williams DA. The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment. Blood. 121: 2474-82. PMID 23335370 DOI: 10.1182/Blood-2012-10-460709  0.347
2013 Walter D, Lier A, Geiselhart A, Huntscha S, Brocks D, Bayindir I, Kaschutnig P, Schmezer P, Lane SW, Essers M, Williams DA, Trumpp A, Milsom MD. HSC Exit From Dormancy Provokes De Novo DNA Damage, Leading To Bone Marrow Failure If Unresolved By The Fanconi Anemia Pathway Blood. 122: 799-799. DOI: 10.1182/Blood.V122.21.799.799  0.318
2013 Hacein-Bey-Abina S, Bushman F, Armant M, Blanche S, Blondeau J, Caccavelli L, Daley H, Dansereau C, deOliveira S, Guo D, Hopkins G, Lim A, Sci M, London WB, Malani N, ... ... Williams DA, et al. Immune Reconstitution and Preliminary Safety Analysis Of 9 Patients Treated With Somatic Gene Therapy For X-Linked Severe Combined Immunodeficiency (SCID-X1) With a Self-Inactivating Gammaretroviral Vector Blood. 122: 715-715. DOI: 10.1182/Blood.V122.21.715.715  0.353
2013 Bruedigam C, Bagger FO, Kuhn CP, Vu T, Austin R, Heidel FH, Bullinger L, Hill GR, Armstrong SA, Williams DA, Lane SW. Inhibition Of Telomerase Is a Novel and Effective Therapy In MLL-Rearranged Acute Myeloid Leukemia (AML) Blood. 122: 2887-2887. DOI: 10.1182/Blood.V122.21.2887.2887  0.348
2013 Reddy PN, Wood J, Harris CE, Xu K, McGuinness M, Radu M, Kosoff R, Chernoff J, Williams DA. Kinase Activity Of Pak2, An Effector Of Rac/CDC42 and Its Interaction With β-PIX Is Required For Murine Hematopoietic Stem Cell Shape, F-Actin Formation, Directional Migration In Vitro and For HSPC Homing To Bone Marrow In Vivo Blood. 122: 2419-2419. DOI: 10.1182/Blood.V122.21.2419.2419  0.316
2012 Crequer A, Troeger A, Patin E, Ma CS, Picard C, Pedergnana V, Fieschi C, Lim A, Abhyankar A, Gineau L, Mueller-Fleckenstein I, Schmidt M, Taieb A, Krueger J, Abel L, ... ... Williams DA, et al. Human RHOH deficiency causes T cell defects and susceptibility to EV-HPV infections. The Journal of Clinical Investigation. 122: 3239-47. PMID 22850876 DOI: 10.1172/Jci62949  0.301
2012 Müller LU, Schlaeger TM, DeVine AL, Williams DA. Induced pluripotent stem cells as a tool for gaining new insights into Fanconi anemia. Cell Cycle (Georgetown, Tex.). 11: 2985-90. PMID 22825249 DOI: 10.4161/Cc.21109  0.342
2012 van der Loo JC, Swaney WP, Grassman E, Terwilliger A, Higashimoto T, Schambach A, Hacein-Bey-Abina S, Nordling DL, Cavazzana-Calvo M, Thrasher AJ, Williams DA, Reeves L, Malik P. Critical variables affecting clinical-grade production of the self-inactivating gamma-retroviral vector for the treatment of X-linked severe combined immunodeficiency. Gene Therapy. 19: 872-6. PMID 22551777 DOI: 10.1038/Gt.2012.37  0.317
2012 Troeger A, Johnson AJ, Wood J, Blum WG, Andritsos LA, Byrd JC, Williams DA. RhoH is critical for cell-microenvironment interactions in chronic lymphocytic leukemia in mice and humans. Blood. 119: 4708-18. PMID 22474251 DOI: 10.1182/Blood-2011-12-395939  0.344
2012 Müller LU, Milsom MD, Harris CE, Vyas R, Brumme KM, Parmar K, Moreau LA, Schambach A, Park IH, London WB, Strait K, Schlaeger T, Devine AL, Grassman E, D'Andrea A, ... ... Williams DA, et al. Overcoming reprogramming resistance of Fanconi anemia cells. Blood. 119: 5449-57. PMID 22371882 DOI: 10.1182/Blood-2012-02-408674  0.356
2012 Lane SW, De Vita S, Alexander KA, Karaman R, Milsom MD, Dorrance AM, Purdon A, Louis L, Bouxsein ML, Williams DA. Rac signaling in osteoblastic cells is required for normal bone development but is dispensable for hematopoietic development. Blood. 119: 736-44. PMID 22123845 DOI: 10.1182/Blood-2011-07-368753  0.358
2012 Renella R, Perlov A, Harris CE, Bauer DE, Xu J, Guda S, Milsom MD, Orkin SH, Williams DA. Hematopoietic SIN Lentiviral Micro RNA-Mediated Silencing of BCL11A: Pre-Clinical Evidence for a Sickle Cell Disease Gene-Therapy Trial Blood. 120: 753-753. DOI: 10.1182/Blood.V120.21.753.753  0.338
2012 De Vita S, Harris CE, Renella R, Mathieu R, McGuinness M, Williams DA. Vav1 Deficiency Differentially Affects Engraftment of Fetal Hematopoietic Organs During Development Compared with Adult Marrow After Transplantation Blood. 120: 1212-1212. DOI: 10.1182/Blood.V120.21.1212.1212  0.334
2011 Croke M, Ross FP, Korhonen M, Williams DA, Zou W, Teitelbaum SL. Rac deletion in osteoclasts causes severe osteopetrosis. Journal of Cell Science. 124: 3811-21. PMID 22114304 DOI: 10.1242/Jcs.086280  0.314
2011 Mondal S, Ghosh-Roy S, Loison F, Li Y, Jia Y, Harris C, Williams DA, Luo HR. PTEN negatively regulates engulfment of apoptotic cells by modulating activation of Rac GTPase. Journal of Immunology (Baltimore, Md. : 1950). 187: 5783-94. PMID 22043008 DOI: 10.4049/Jimmunol.1100484  0.302
2011 Lane SW, Wang YJ, Lo Celso C, Ragu C, Bullinger L, Sykes SM, Ferraro F, Shterental S, Lin CP, Gilliland DG, Scadden DT, Armstrong SA, Williams DA. Differential niche and Wnt requirements during acute myeloid leukemia progression Blood. 118: 2849-2856. PMID 21765021 DOI: 10.1182/Blood-2011-03-345165  0.328
2011 Sanchez-Aguilera A, Lee YJ, Lo Celso C, Ferraro F, Brumme K, Mondal S, Kim C, Dorrance A, Luo HR, Scadden DT, Williams DA. Guanine nucleotide exchange factor Vav1 regulates perivascular homing and bone marrow retention of hematopoietic stem and progenitor cells. Proceedings of the National Academy of Sciences of the United States of America. 108: 9607-12. PMID 21606370 DOI: 10.1073/Pnas.1102018108  0.355
2011 Tolar J, Adair JE, Antoniou M, Bartholomae CC, Becker PS, Blazar BR, Bueren J, Carroll T, Cavazzana-Calvo M, Clapp DW, Dalgleish R, Galy A, Gaspar HB, Hanenberg H, Von Kalle C, ... ... Williams DA, et al. Stem cell gene therapy for fanconi anemia: report from the 1st international Fanconi anemia gene therapy working group meeting. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 1193-8. PMID 21540837 DOI: 10.1038/Mt.2011.78  0.33
2011 Dorrance AM, Kosoff R, McGuinness M, Harris C, De Vita S, Mathieu R, Lane SW, Milsom MD, Chernoff J, Williams DA. Pak A Proteins Are Essential for Hematopoietic Stem/Progenitor Cell (HSC/P) Engraftment Through Regulation of Signaling Pathways Controlling HSC/P Proliferation, Survival, Migration, and the Actin Cytoskeleton Blood. 118: 917-917. DOI: 10.1182/Blood.V118.21.917.917  0.343
2011 Mueller L, Milsom MD, Harris C, Vyas R, Brumme K, Parmar K, Schambach A, Grassman E, Park I, Wendy L, Strait K, Schlaeger T, Devine AL, D'Andrea AD, Daley GQ, ... Williams DA, et al. Gene-Correction Rescues Reprogramming of Fanconi Anemia Fibroblasts and Enables Hematopoietic Differentiation of FA Induced Pluripotent Stem Cells in Vitro and In Vivo Blood. 118: 672-672. DOI: 10.1182/Blood.V118.21.672.672  0.358
2011 Troeger A, Chae H, Wood J, Williams DA. Functional Characterization of the RhoH c-Terminus and Insert Domain As Potential Drug Targets Blood. 118: 1781-1781. DOI: 10.1182/Blood.V118.21.1781.1781  0.314
2011 Pai S, Notarangelo LD, Harris C, Cattaneo F, Wladkowski M, Armant M, Kao GS, Wielgosz M, Nienhuis AW, Modlich U, Brugman M, Schambach A, Rothe M, Thornhill SI, Gaspar HB, ... ... Williams DA, et al. Somatic Gene Therapy for X-Linked Severe Combined Immunodeficiency Using a Self-Inactivating Modified Gammaretroviral Vector Results in An Improved Preclinical Safety Profile and Early Clinical Efficacy in a Human Patient Blood. 118: 164-164. DOI: 10.1182/Blood.V118.21.164.164  0.375
2011 Mizukawa B, Shrestha M, Wunderlich M, Chou F, Griesinger A, Kumar A, Zheng Y, Williams DA, Mulloy JC. Rac GTPase Survival Signaling Through Anti-Apoptotic Bcl-2 Proteins Reveals a Target for Combination Therapy in MLL-AF9 Acute Myeloid Leukemia Blood. 118: 1536-1536. DOI: 10.1182/Blood.V118.21.1536.1536  0.343
2010 Williams DA, Keating A. Enhancing research in regenerative medicine. Blood. 116: 866-7. PMID 20705767 DOI: 10.1182/Blood-2010-05-282723  0.31
2010 Milsom MD, Williams DA. Gaining the hard yard: pre-clinical evaluation of lentiviral-mediated gene therapy for the treatment of beta-thalassemia. Embo Molecular Medicine. 2: 291-3. PMID 20677209 DOI: 10.1002/Emmm.201000086  0.333
2010 Sengupta A, Arnett J, Dunn S, Williams DA, Cancelas JA. Rac2 GTPase deficiency depletes BCR-ABL+ leukemic stem cells and progenitors in vivo. Blood. 116: 81-4. PMID 20407032 DOI: 10.1182/Blood-2009-10-247437  0.331
2010 Lane SW, Sykes SM, Al-Shahrour F, Shterental S, Paktinat M, Lo Celso C, Jesneck JL, Ebert BL, Williams DA, Gilliland DG. The Apc(min) mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS. Blood. 115: 3489-97. PMID 20197553 DOI: 10.1182/Blood-2009-11-251728  0.334
2010 Kalfa TA, Pushkaran S, Zhang X, Johnson JF, Pan D, Daria D, Geiger H, Cancelas JA, Williams DA, Zheng Y. Rac1 and Rac2 GTPases are necessary for early erythropoietic expansion in the bone marrow but not in the spleen. Haematologica. 95: 27-35. PMID 20065081 DOI: 10.3324/Haematol.2009.006239  0.318
2010 Sanchez-Aguilera A, Rattmann I, Drew DZ, Müller LU, Summey V, Lucas DM, Byrd JC, Croce CM, Gu Y, Cancelas JA, Johnston P, Moritz T, Williams DA. Involvement of RhoH GTPase in the development of B-cell chronic lymphocytic leukemia. Leukemia. 24: 97-104. PMID 19847197 DOI: 10.1038/Leu.2009.217  0.333
2010 Xu J, Szczur K, Xu H, Geiger H, Zheng Y, Srour E, Williams DA, Filippi M. Rho GTPase Activating Protein p190-B Regulates Hematopoietic Stem Cell Fate Decision Blood. 116: 575-575. DOI: 10.1182/Blood.V116.21.575.575  0.326
2010 Sanchez-Aguilera A, Lee Y, Lo Celso C, Ferraro F, Brumme K, Mondal S, Kim C, Adrienne D, Luo HR, Scadden DT, Williams DA. Vav1 Regulates Perivascular Homing, Bone Marrow Retention and Engraftment of Hematopoietic Stem Cells Via SDF1a Signaling Blood. 116: 400-400. DOI: 10.1182/Blood.V116.21.400.400  0.357
2010 Troeger A, Johann P, Senturk M, Milsom MD, Williams DA. Intact Rac Signaling Is Important for Leukemia Cell Survival Blood. 116: 2885-2885. DOI: 10.1182/Blood.V116.21.2885.2885  0.327
2010 Dorrance AM, Sanchez-Aguilera A, Vita SD, Milsom MD, Chernoff J, Williams DA. Group A Pak Proteins Are Essential for HSC/P Engraftment. Blood. 116: 2624-2624. DOI: 10.1182/Blood.V116.21.2624.2624  0.35
2010 Mueller L, Milsom MD, Brumme K, Harris C, Parmar K, Zhu K, Wendy L, Strait K, D'Andrea AD, Daley GQ, Williams DA. Mechanisms of Resistance to Reprogramming of Cells Defective In the Fanconi Anemia DNA Repair Pathway Blood. 116: 196-196. DOI: 10.1182/Blood.V116.21.196.196  0.347
2010 Lane SW, Sykes SM, Ferraro F, Lin CP, Gilliland DG, Williams DA, Scadden DT, Celso CL. Leukemia stem cells occupy niches that are physically distinct and independent of the normal constraints that apply to hematopoietic stem cells Experimental Hematology. 38. DOI: 10.1016/J.Exphem.2010.07.008  0.307
2009 Williams DA. Correction and apology Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 1660. PMID 19789558 DOI: 10.1038/Mt.2009.212  0.302
2009 Xu H, Eleswarapu S, Geiger H, Szczur K, Daria D, Zheng Y, Settleman J, Srour EF, Williams DA, Filippi MD. Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential. Blood. 114: 3557-66. PMID 19713466 DOI: 10.1182/Blood-2009-02-205815  0.316
2009 Williams DA. Gene therapy continues to mature and to face challenges Molecular Therapy. 17: 1305-1306. PMID 19644491 DOI: 10.1038/Mt.2009.162  0.319
2009 Müller LU, Williams DA. Finding the needle in the hay stack: hematopoietic stem cells in Fanconi anemia. Mutation Research. 668: 141-9. PMID 19508850 DOI: 10.1016/J.Mrfmmm.2009.03.010  0.349
2009 Williams DA. Rapid development of pluripotent stem cells as a potential therapeutic modality Molecular Therapy. 17: 929-930. PMID 19483764 DOI: 10.1038/Mt.2009.97  0.321
2009 Cancelas JA, Williams DA. Rho GTPases in hematopoietic stem cell functions. Current Opinion in Hematology. 16: 249-54. PMID 19417647 DOI: 10.1097/Moh.0B013E32832C4B80  0.323
2009 Williams DA. Recombinant DNA advisory committee updates recommendations on gene transfer for X-linked severe combined immunodeficiency Molecular Therapy. 17: 751-752. PMID 19404322 DOI: 10.1038/Mt.2009.76  0.316
2009 Müller LUW, Daley GQ, Williams DA. Upping the ante: recent advances in direct reprogramming. Molecular Therapy. 17: 947-953. PMID 19337233 DOI: 10.1038/Mt.2009.72  0.334
2009 Williams DA. Progress in genetic therapy for severe combined immunodeficiency associated with adenosine deaminase deficiency Molecular Therapy. 17: 577-578. PMID 19337228 DOI: 10.1038/Mt.2009.57  0.337
2009 Williams DA. ESCGT 2008: Progress in clinical gene therapy Molecular Therapy. 17: 1-2. PMID 19116631 DOI: 10.1038/Mt.2008.277  0.364
2009 Sanchez-Aguilera A, Lee Y, Lo Celso C, Brumme K, Lin CP, Scadden DT, Williams DA. Regulation of Rho GTPases by the Hematopoietic-Specific Guanine Nucleotide Exchange Factor Vav1 Is Critical for Hematopoietic Stem Cell Retention in the Endosteal Niche and Engraftment. Blood. 114: 80-80. DOI: 10.1182/Blood.V114.22.80.80  0.35
2009 Chang K, Sanchez-Aguilera A, Sengupta A, Arnett J, Dunn S, Williams DA, Cancelas J. Vav3 and Rac2 Activation Are Required for B Progenitor Transformation Induced by p190-BCR-ABL. Blood. 114: 449-449. DOI: 10.1182/Blood.V114.22.449.449  0.317
2009 Mizukawa B, Wei J, Wunderlich M, Chou F, Zheng Y, Williams DA, Mulloy JC. Bcl-XL Is a Critical Mediator of Rac Signaling in MLL-AF9-Induced Acute Myeloid Leukemia. Blood. 114: 1971-1971. DOI: 10.1182/Blood.V114.22.1971.1971  0.335
2009 Milsom MD, Yabuuchi A, Daley GQ, Williams DA. The Rho GTPase Rac1 Is Not Required for Definitive Hematopoietic Specification in ES-Derived Hematopoiesis. Blood. 114: 1494-1494. DOI: 10.1182/Blood.V114.22.1494.1494  0.315
2009 Lane SW, Celso CL, Sykes SM, Shterental S, Paktinat M, Lin CP, Williams DA, Scadden DT, Gilliland DG. Leukemia Stem Cells Are Resistant to In Vivo, Cell Non-Autonomous Wnt Inhibition. Blood. 114: 1025-1025. DOI: 10.1182/Blood.V114.22.1025.1025  0.347
2008 Müller LU, Milsom MD, Kim MO, Schambach A, Schuesler T, Williams DA. Rapid Lentiviral Transduction Preserves the Engraftment Potential of Fanca(-/-) Hematopoietic Stem Cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 1154-1160. PMID 28178472 DOI: 10.1038/Mt.2008.67  0.369
2008 Gan B, Sahin E, Jiang S, Sanchez-Aguilera A, Scott KL, Chin L, Williams DA, Kwiatkowski DJ, DePinho RA. mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization. Proceedings of the National Academy of Sciences of the United States of America. 105: 19384-9. PMID 19052232 DOI: 10.1073/Pnas.0810584105  0.32
2008 Milsom MD, Jerabek-Willemsen M, Harris CE, Schambach A, Broun E, Bailey J, Jansen M, Schleimer D, Nattamai K, Wilhelm J, Watson A, Geiger H, Margison GP, Moritz T, Baum C, ... ... Williams DA, et al. Reciprocal relationship between O6-methylguanine-DNA methyltransferase P140K expression level and chemoprotection of hematopoietic stem cells. Cancer Research. 68: 6171-80. PMID 18676840 DOI: 10.1158/0008-5472.Can-08-0320  0.304
2008 Müller LU, Schore RJ, Zheng Y, Thomas EK, Kim MO, Cancelas JA, Gu Y, Williams DA. Rac guanosine triphosphatases represent a potential target in AML. Leukemia. 22: 1803-6. PMID 18668135 DOI: 10.1038/Leu.2008.196  0.362
2008 Guo F, Cancelas JA, Hildeman D, Williams DA, Zheng Y. Rac GTPase isoforms Rac1 and Rac2 play a redundant and crucial role in T-cell development Blood. 112: 1767-1775. PMID 18579797 DOI: 10.1182/Blood-2008-01-132068  0.306
2008 Zhang X, Shang X, Guo F, Murphy K, Kirby M, Kelly P, Reeves L, Smith FO, Williams DA, Zheng Y, Pang Q. Defective homing is associated with altered Cdc42 activity in cells from patients with Fanconi anemia group A. Blood. 112: 1683-6. PMID 18565850 DOI: 10.1182/Blood-2008-03-147090  0.347
2008 Yamada Y, Sanchez-Aguilera A, Brandt EB, McBride M, Al-Moamen NJ, Finkelman FD, Williams DA, Cancelas JA, Rothenberg ME. FIP1L1/PDGFRalpha synergizes with SCF to induce systemic mastocytosis in a murine model of chronic eosinophilic leukemia/hypereosinophilic syndrome. Blood. 112: 2500-7. PMID 18539901 DOI: 10.1182/Blood-2007-11-126268  0.313
2008 Sadelain M, Williams DA. A "vector drain" in US gene therapy development? Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 801-2. PMID 18432266 DOI: 10.1038/Mt.2008.71  0.455
2008 Williams DA, Zheng Y, Cancelas JA. Rho GTPases and regulation of hematopoietic stem cell localization. Methods in Enzymology. 439: 365-93. PMID 18374178 DOI: 10.1016/S0076-6879(07)00427-2  0.36
2008 Thornhill SI, Schambach A, Howe SJ, Ulaganathan M, Grassman E, Williams D, Schiedlmeier B, Sebire NJ, Gaspar HB, Kinnon C, Baum C, Thrasher AJ. Self-inactivating gammaretroviral vectors for gene therapy of X-linked severe combined immunodeficiency. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 590-8. PMID 18180772 DOI: 10.1038/Sj.Mt.6300393  0.304
2008 Grimes HL, Velu CS, Horman S, Chaubey A, Bourdeau T, Xu H, Zhu J, Paul W, Colmenares C, Williams DA, Gebelein B. Gfi1 as a Regulator of Hematopoietic Differentiation. Blood. 112: sci-16-sci-16. DOI: 10.1182/Blood.V112.11.Sci-16.Sci-16  0.325
2008 Xu H, Geiger H, Szczur K, Deira D, Zheng Y, Settleman J, Srour E, Williams DA, Filippi M. Absence of the Rho GTPase Activating Protein p190-B Enhances Long Term Hematopoietic Stem Cell Engraftment Blood. 112: 614-614. DOI: 10.1182/Blood.V112.11.614.614  0.337
2008 Grassman E, Higashimoto T, Rohrbach J, Hall D, Williams DA, Reeves L, Malik P. Pulmozyme® Treatment of Vectors Produced by Transient Transfection Reduces Residual Plasmid DNA on Human CD34+ Hematopoietic Progenitor Cells without Loss of Transduction or Engraftment Efficiency Blood. 112: 4626-4626. DOI: 10.1182/Blood.V112.11.4626.4626  0.343
2008 Sanchez-Aguilera A, Sengupta At, Mastin JP, Chang KH, Williams DA, Cancelas JA. Rac2 GTPase Activation Is Necessary for Development of p190-BCR-ABL-Induced B-Cell Acute Lymphoblastic Leukemia Blood. 112: 3790-3790. DOI: 10.1182/Blood.V112.11.3790.3790  0.301
2008 Wei J, Wunderlich M, Harris C, Mizukawa B, Zheng Y, Williams DA, Mulloy JC. Rac GTPases Are Required for MLL-AF9-Induced Mixed Lineage Leukemia. Blood. 112: 3368-3368. DOI: 10.1182/Blood.V112.11.3368.3368  0.356
2008 Velu CS, Berk M, Xu H, Bourdeau T, Kazanjian A, Williams DA, Colmenares C, Grimes HL. The Ski oncoprotein regulates Hematopoietic Stem Cell Fitness and Functions as a Corepressor for Gfi1. Blood. 112: 1403-1403. DOI: 10.1182/Blood.V112.11.1403.1403  0.337
2008 Zhang X, Shang X, Guo F, Murphy K, Kirby M, Kelly P, Reeves L, Smith FO, Williams DA, Zheng Y, Pang Q. A Cell-Autonomous Defect of Bone Marrow Hematopoietic Stem/Progenitor Cells and Impaired Stromal Function in FA-a Patients Blood. 112: 1364-1364. DOI: 10.1182/Blood.V112.11.1364.1364  0.356
2007 Williams DA. An international conversation on stem cell gene therapy Molecular Therapy. 15: 2058-2059. PMID 18026181 DOI: 10.1038/Sj.Mt.6300358  0.33
2007 Yang L, Wang L, Kalfa TA, Cancelas JA, Shang X, Pushkaran S, Mo J, Williams DA, Zheng Y. Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis. Blood. 110: 3853-61. PMID 17702896 DOI: 10.1182/Blood-2007-03-079582  0.346
2007 Ball CR, Pilz IH, Schmidt M, Fessler S, Williams DA, Von Kalle C, Glimm H. Stable differentiation and clonality of murine long-term hematopoiesis after extended reduced-intensity selection for MGMT P140K transgene expression Blood. 110: 1779-1787. PMID 17496202 DOI: 10.1182/Blood-2006-11-053710  0.341
2007 Milsom MD, Williams DA. Live and let die: in vivo selection of gene-modified hematopoietic stem cells via MGMT-mediated chemoprotection. Dna Repair. 6: 1210-21. PMID 17482893 DOI: 10.1016/J.Dnarep.2007.03.020  0.359
2007 Zhang X, Sejas DP, Qiu Y, Williams DA, Pang Q. Inflammatory ROS promote and cooperate with the Fanconi anemia mutation for hematopoietic senescence. Journal of Cell Science. 120: 1572-83. PMID 17405815 DOI: 10.1242/Jcs.003152  0.307
2007 Williams DA. Are lentivirus vectors safer? Molecular Therapy. 15: 439. PMID 17311027 DOI: 10.1038/Sj.Mt.6300111  0.313
2007 Will E, Bailey J, Schuesler T, Modlich U, Balcik B, Burzynski B, Witte D, Layh-Schmitt G, Rudolph C, Schlegelberger B, von Kalle C, Baum C, Sorrentino BP, Wagner LM, Kelly P, ... ... Williams DA, et al. Importance of murine study design for testing toxicity of retroviral vectors in support of phase I trials. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 782-91. PMID 17299409 DOI: 10.1038/Sj.Mt.6300083  0.335
2007 Williams DA, Cancelas JA. Leukaemia: niche retreats for stem cells. Nature. 444: 827-8. PMID 17167463 DOI: 10.1038/444827A  0.327
2007 Kelly PF, Radtke S, von Kalle C, Balcik B, Bohn K, Mueller R, Schuesler T, Haren M, Reeves L, Cancelas JA, Leemhuis T, Harris R, Auerbach AD, Smith FO, Davies SM, ... Williams DA, et al. Stem cell collection and gene transfer in Fanconi anemia. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 211-9. PMID 17164793 DOI: 10.1038/Sj.Mt.6300033  0.346
2007 Williams DA, Xu H, Cancelas JA. Children are not little adults: just ask their hematopoietic stem cells. The Journal of Clinical Investigation. 116: 2593-6. PMID 17016556 DOI: 10.1172/Jci30083  0.347
2007 Thomas EK, Cancelas JA, Chae H, Cox AD, Keller PJ, Perrotti D, Neviani P, Druker BJ, Zheng Y, Harris CE, Williams DA. Rac GTPases Are Potential Therapeutic Targets in p210-BCR-ABL-Induced Myeloproliferative Disease (MPD). Blood. 110: 465-465. DOI: 10.1182/Blood.V110.11.465.465  0.35
2007 Velu CS, Porteous S, Xu H, Baktula AM, Roehrs P, Bourdeau T, Stavnezer E, Williams D, Colmenares C, Grimes HL. microRNA Control of Hematopoietic Stem Cell Fitness and Myelopoiesis. Blood. 110: 373-373. DOI: 10.1182/Blood.V110.11.373.373  0.304
2007 Muller LU, Milsom M, Harris CE, Bailey J, Williams DA. The Sooner the Better: Rapid Transduction Enhances the Engraftment/Selection of Gene Corrected Fanconi Anemia HSC. Blood. 110: 194-194. DOI: 10.1182/Blood.V110.11.194.194  0.381
2006 Debidda M, Williams DA, Zheng Y. Rac1 GTPase regulates cell genomic stability and senescence. The Journal of Biological Chemistry. 281: 38519-28. PMID 17032649 DOI: 10.1074/Jbc.M604607200  0.322
2006 Cancelas JA, Jansen M, Williams DA. The role of chemokine activation of Rac GTPases in hematopoietic stem cell marrow homing, retention, and peripheral mobilization. Experimental Hematology. 34: 976-85. PMID 16863904 DOI: 10.1016/J.Exphem.2006.03.016  0.309
2006 Ghiaur G, Lee A, Bailey J, Cancelas JA, Zheng Y, Williams DA. Inhibition of RhoA GTPase activity enhances hematopoietic stem and progenitor cell proliferation and engraftment. Blood. 108: 2087-94. PMID 16709932 DOI: 10.1182/Blood-2006-02-001560  0.337
2006 Guo F, Debidda M, Yang L, Williams DA, Zheng Y. Genetic deletion of Rac1 GTPase reveals its critical role in actin stress fiber formation and focal adhesion complex assembly. The Journal of Biological Chemistry. 281: 18652-9. PMID 16698790 DOI: 10.1074/Jbc.M603508200  0.302
2006 Cornetta K, Croop J, Dropcho E, Abonour R, Kieran MW, Kreissman S, Reeves L, Erickson LC, Williams DA. A pilot study of dose-intensified procarbazine, CCNU, vincristine for poor prognosis brain tumors utilizing fibronectin-assisted, retroviral-mediated modification of CD34+ peripheral blood cells with O6-methylguanine DNA methyltransferase. Cancer Gene Therapy. 13: 886-95. PMID 16645619 DOI: 10.1038/Sj.Cgt.7700963  0.342
2006 Williams DA. An emerging consensus on recommendations to facilitate clinical gene transfer Molecular Therapy. 13: 637-638. PMID 16530487 DOI: 10.1016/J.Ymthe.2006.03.003  0.304
2006 Cancelas JA, Williams DA. Stem cell mobilization by beta2-agonists. Nature Medicine. 12: 278-9. PMID 16520770 DOI: 10.1038/Nm0306-278  0.32
2006 Akbar H, Cancelas J, Williams DA, Zheng J, Zheng Y. Rational design and applications of a Rac GTPase-specific small molecule inhibitor. Methods in Enzymology. 406: 554-65. PMID 16472687 DOI: 10.1016/S0076-6879(06)06043-5  0.318
2006 Will E, Speidel D, Wang Z, Ghiaur G, Rimek A, Schiedlmeier B, Williams DA, Baum C, Ostertag W, Klump H. HOXB4 inhibits cell growth in a dose-dependent manner and sensitizes cells towards extrinsic cues. Cell Cycle (Georgetown, Tex.). 5: 14-22. PMID 16357528 DOI: 10.4161/Cc.5.1.2304  0.321
2006 Schambach A, Bohne J, Chandra S, Will E, Margison GP, Williams DA, Baum C. Equal potency of gammaretroviral and lentiviral SIN vectors for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. 13: 391-400. PMID 16226060 DOI: 10.1016/J.Ymthe.2005.08.012  0.301
2006 Korhonen M, Zhao H, Faccio R, Ross PF, Hopkins TM, Cancelas JA, Williams DA. Rac1 and Rac2 GTPases Play Distinct Roles and Are Essential for Full Osteoclast Differentiation. Blood. 108: 4231-4231. DOI: 10.1182/Blood.V108.11.4231.4231  0.328
2006 Yamada Y, Rothenberg ME, Lee AW, Al-Moamen NJ, Williams DA, Cancelas JA. SCF and IL-5 Synergize with FIP1L1/PDGFRα To Induce Mastocytosis in a Chronic Eosinophilic Leukemia Murine Model. Blood. 108: 3631-3631. DOI: 10.1182/Blood.V108.11.3631.3631  0.305
2006 Ball CR, Schmidt M, Pilz IH, Sylvia F, Williams DA, Kalle Cv, Glimm H. Stable Polyclonal Murine Long-Term Hematopoiesis without Clonal Exhaustion of MGMT P140K Expressing Murine Hematopoietic Stem Cells after Extended Reduced Intensity Selection. Blood. 108: 3271-3271. DOI: 10.1182/Blood.V108.11.3271.3271  0.37
2006 Lee AW, Milsom MD, Zheng Y, Cancelas JA, Williams DA. Improved Engraftment of Bone Marrow and Mobilized Peripheral Blood Stem Cells in a Fanconi Anemia Murine Model. Blood. 108: 3186-3186. DOI: 10.1182/Blood.V108.11.3186.3186  0.303
2006 Xu H, Szczur K, Zheng Y, Settleman J, Williams DA, Filippi M. P190-B RhoGAP Is Critical for Hematopoietic Stem/Progenitor Cell Homing and Short Term Engraftment. Blood. 108: 1341-1341. DOI: 10.1182/Blood.V108.11.1341.1341  0.314
2006 Kelly P, Balcik B, Bohn K, Mueller R, Schuesler T, Reeves L, Leemhuis T, Harris R, Davies S, Smith F, von Kalle C, Williams D. 682. Collection and Genetic Correction of Fanconi Complement Type A Hematopoietic Stem Cells: Results of Two Pilot Studies Molecular Therapy. 13: S263. DOI: 10.1016/J.Ymthe.2006.08.759  0.344
2006 Will E, Bailey J, Schuesler T, Balcik B, Burzynski B, Witte D, Layh-Schmitt G, vonKalle C, Baum C, Sorrentino BP, Wagner LM, Reeves L, Williams DA. 459. Murine Study To Evaluate Long-Term Transgene Expression of the MSCV-MGMTP140K wc Retroviral Vector in Support of a Phase I Gene Transfer Trial-Limitations of the Murine Model as a Pre-Clinical Tool Molecular Therapy. 13: S177-S178. DOI: 10.1016/J.Ymthe.2006.08.528  0.322
2006 Worsham DN, Wang D, von Kalle C, Williams DA, Pan D. 97. Translational Studies toward Optimizing In Vivo Bone Marrow Stem Cell Gene Transfer Using Lentiviral Vector Molecular Therapy. 13: S40. DOI: 10.1016/J.Ymthe.2006.08.116  0.348
2006 Yamada Y, Cancelas J, Lee A, Williams D, Rothenberg M. FIP1L1-PDGFRα Induces Stem Cell Factor Dependent Eosinophil and Mast Cell Development from Murine Hematopoietic Stem Cell/Progenitors in Vitro Journal of Allergy and Clinical Immunology. 117: S271. DOI: 10.1016/J.Jaci.2005.12.1070  0.321
2005 Villella AD, Yao J, Getty RR, Juliar BE, Yiannoutsos C, Hartwell JR, Cai S, Sadat MA, Cornetta K, Williams DA, Pollok KE. Real-Time PCR: an Effective Tool for Measuring Transduction Efficiency in Human Hematopoietic Progenitor Cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. 11: 483-491. PMID 28192683 DOI: 10.1016/J.Ymthe.2004.10.017  0.319
2005 Cancelas JA, Lee AW, Prabhakar R, Stringer KF, Zheng Y, Williams DA. Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization. Nature Medicine. 11: 886-91. PMID 16025125 DOI: 10.1038/Nm1274  0.331
2005 Gu Y, Zheng Y, Williams DA. RhoH GTPase: a key regulator of hematopoietic cell proliferation and apoptosis? Cell Cycle (Georgetown, Tex.). 4: 201-2. PMID 15611634 DOI: 10.4161/Cc.4.2.1490  0.32
2005 Filippi M, Szczur K, Xu H, Zheng Y, Settleman J, Williams DA. Regulation of the Rho GTPase, RhoA, Activity Is Critical for Erythropoiesis during Embryo Development. Blood. 106: 829-829. DOI: 10.1182/Blood.V106.11.829.829  0.313
2005 Filippi M, Xu H, Szczur K, Zheng Y, Williams DA. Rho GTPase CDC42 Signals Separately Regulate Directed Migration Versus Random Movement in Neutrophil. Blood. 106: 636-636. DOI: 10.1182/Blood.V106.11.636.636  0.304
2005 Filippi M, Berclaz P, Szczur K, Harris C, Williams DA. Cross Talk between Rho GTPases Is Critical for Hematopoietic-Derived Inflammatory Processes. Blood. 106: 631-631. DOI: 10.1182/Blood.V106.11.631.631  0.322
2005 Kelly P, Balcik B, Bohn K, Mueller R, Jurickova I, Schuesler T, Reeves L, Leemhuis T, Harris R, Davies SM, Smith FO, von Kalle C, Williams DA. Early Results of the Clinical Collection and Genetic Correction of Fanconi Complement Type A Hematopoietic Stem Cells. Blood. 106: 1283-1283. DOI: 10.1182/Blood.V106.11.1283.1283  0.345
2005 Schore RJ, Zheng Y, Williams DA, Gu Y. Inhibition of the Rho GTPase, Rac, Differentially Inhibits Proliferation of AML Cell Lines and May Serve as a Novel Molecular Target. Blood. 106: 1205-1205. DOI: 10.1182/Blood.V106.11.1205.1205  0.34
2005 Schambach A, Bohne J, Chandra S, Will E, Mueller L, Margison G, Williams DA, Baum C. 829. Design of a Safe and Efficient Vector for Bone Marrow Chemoprotection by O6-Methyl-Guanine-DNA-MethylTransferase Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.372  0.328
2005 Worsham DN, Bohn K, Kuhel D, Williams DA, Kalle Cv, Pan D. 6. In Vivo Adult Stem Cell Gene Transfer in Mice by In Situ Delivery of a Self-Inactivating Lentiviral Vector Using Intrafemoral Injection Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.009  0.351
2004 von Kalle C, Baum C, Williams DA. Lenti in red: progress in gene therapy for human hemoglobinopathies. The Journal of Clinical Investigation. 114: 889-91. PMID 15467825 DOI: 10.1172/Jci200423132  0.303
2004 Baum C, von Kalle C, Staal FJ, Li Z, Fehse B, Schmidt M, Weerkamp F, Karlsson S, Wagemaker G, Williams DA. Chance or necessity? Insertional mutagenesis in gene therapy and its consequences. Molecular Therapy : the Journal of the American Society of Gene Therapy. 9: 5-13. PMID 14741772 DOI: 10.1016/J.Ymthe.2003.10.013  0.325
2004 Filippi M, Xu H, Towe J, Harris CE, Szczur K, Wang L, Atkinson S, Zheng Y, Williams DA. The RHO GTPASE CDC42 Regulator CDC42GAP Plays a Critical Role in Neutrophil Migration Via Podosome-Like Formation. Blood. 104: 651-651. DOI: 10.1182/Blood.V104.11.651.651  0.314
2004 Pan D, von Kalle C, Williams DA, Worsham DN, Bohn K, Lutz C. In Vivo Bone Marrow Stem Cell Gene Transfer in Mice by In Situ Delivery of a 3rd-Generation Lentiviral Vector Using Intrafemoral Injection. Blood. 104: 2104-2104. DOI: 10.1182/Blood.V104.11.2104.2104  0.35
2004 Kalfa TA, Pushkaran S, Johnson JF, Wei Q, Williams DA, Zheng Y. Erythrocyte Cytoskeletal Defects Induced in Mice by Deletion of Rac GTPases. Blood. 104: 1573-1573. DOI: 10.1182/Blood.V104.11.1573.1573  0.312
2004 Cancelas JA, Lee AW, Prabhakar R, Jansen M, Zheng Y, Williams DA. Rac1 and Rac2 Rho GTPases Distinctly Regulate Stem Cell Engraftment and Mobilization and Are Novel Targets for Pharmacologically-Induced Progenitor Mobilization. Blood. 104: 115-115. DOI: 10.1182/Blood.V104.11.115.115  0.329
2003 Pollok KE, Hartwell JR, Braber A, Cooper RJ, Jansen M, Ragg S, Bailey BJ, Erickson LC, Kreklau EL, Williams DA. In vivo selection of human hematopoietic cells in a xenograft model using combined pharmacologic and genetic manipulations. Human Gene Therapy. 14: 1703-14. PMID 14670122 DOI: 10.1089/104303403322611728  0.353
2003 Gu Y, Filippi MD, Cancelas JA, Siefring JE, Williams EP, Jasti AC, Harris CE, Lee AW, Prabhakar R, Atkinson SJ, Kwiatkowski DJ, Williams DA. Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatases. Science (New York, N.Y.). 302: 445-9. PMID 14564009 DOI: 10.1126/Science.1088485  0.341
2003 Tan BL, Yazicioglu MN, Ingram D, McCarthy J, Borneo J, Williams DA, Kapur R. Genetic evidence for convergence of c-Kit- and alpha4 integrin-mediated signals on class IA PI-3kinase and the Rac pathway in regulating integrin-directed migration in mast cells. Blood. 101: 4725-32. PMID 12560232 DOI: 10.1182/Blood-2002-08-2521  0.305
2003 Baum C, Düllmann J, Li Z, Fehse B, Meyer J, Williams DA, von Kalle C. Side effects of retroviral gene transfer into hematopoietic stem cells. Blood. 101: 2099-114. PMID 12511419 DOI: 10.1182/Blood-2002-07-2314  0.358
2003 Neff T, Horn PA, Peterson LJ, Thomasson BM, Thompson J, Williams DA, Schmidt M, Georges GE, Kalle Cv, Kiem H. Methylguanine methyltransferase–mediated in vivo selection and chemoprotection of allogeneic stem cells in a large-animal model Journal of Clinical Investigation. 112: 1581-1588. DOI: 10.1172/Jci200318782  0.363
2002 Gu Y, Byrne MC, Paranavitana NC, Aronow B, Siefring JE, D'Souza M, Horton HF, Quilliam LA, Williams DA. Rac2, a hematopoiesis-specific Rho GTPase, specifically regulates mast cell protease gene expression in bone marrow-derived mast cells. Molecular and Cellular Biology. 22: 7645-57. PMID 12370311 DOI: 10.1128/Mcb.22.21.7645-7657.2002  0.333
2002 Jansen M, Sorg UR, Ragg S, Flasshove M, Seeber S, Williams DA, Moritz T. Hematoprotection and enrichment of transduced cells in vivo after gene transfer of MGMT(P140K) into hematopoietic stem cells. Cancer Gene Therapy. 9: 737-46. PMID 12189523 DOI: 10.1038/Sj.Cgt.7700490  0.342
2002 Tao W, Filippi M, Bailey JR, Atkinson SJ, Connors B, Evan A, Williams DA. The TRQQKRP motif located near the C-terminus of Rac2 is essential for Rac2 biologic functions and intracellular localization Blood. 100: 1679-1688. DOI: 10.1182/Blood.V100.5.1679.H81702001679_1679_1688  0.302
2001 Pollok KE, van Der Loo JC, Cooper RJ, Hartwell JR, Miles KR, Breese R, Williams EP, Montel A, Seshadri R, Hanenberg H, Williams DA. Differential transduction efficiency of SCID-repopulating cells derived from umbilical cord blood and granulocyte colony-stimulating factor-mobilized peripheral blood. Human Gene Therapy. 12: 2095-108. PMID 11747599 DOI: 10.1089/10430340152677430  0.34
2001 Croop JM, Cooper R, Fernandez C, Graves V, Kreissman S, Hanenberg H, Smith FO, Williams DA. Mobilization and collection of peripheral blood CD34+ cells from patients with Fanconi anemia. Blood. 98: 2917-21. PMID 11698271 DOI: 10.1182/Blood.V98.10.2917  0.3
2001 Gu Y, Jia B, Yang FC, D'Souza M, Harris CE, Derrow CW, Zheng Y, Williams DA. Biochemical and biological characterization of a human Rac2 GTPase mutant associated with phagocytic immunodeficiency. The Journal of Biological Chemistry. 276: 15929-38. PMID 11278678 DOI: 10.1074/Jbc.M010445200  0.372
2000 Williams DA, Nienhuis AW, Hawley RG, Smith FO. Gene Therapy 2000. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 376-393. PMID 11701552 DOI: 10.1182/Asheducation-2000.1.376  0.354
2000 Williams DA, Smith FO. Progress in the use of gene transfer methods to treat genetic blood diseases. Human Gene Therapy. 11: 2059-66. PMID 11044908 DOI: 10.1089/104303400750001372  0.332
2000 Abonour R, Williams DA, Einhorn L, Hall KM, Chen J, Coffman J, Traycoff CM, Bank A, Kato I, Ward M, Williams SD, Hromas R, Robertson MJ, Smith FO, Woo D, et al. Efficient retrovirus-mediated transfer of the multidrug resistance 1 gene into autologous human long-term repopulating hematopoietic stem cells. Nature Medicine. 6: 652-8. PMID 10835681 DOI: 10.1038/76225  0.341
2000 Williams DA, Tao W, Yang F, Kim C, Gu Y, Mansfield P, Levine JE, Petryniak B, Derrow CW, Harris C, Jia B, Zheng Y, Ambruso DR, Lowe JB, Atkinson SJ, et al. Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency Blood. 96: 1646-1654. DOI: 10.1182/Blood.V96.5.1646.H8001646_1646_1654  0.335
2000 Gommerman JL, Sittaro D, Klebasz NZ, Williams DA, Berger SA. Differential stimulation of c-Kit mutants by membrane-bound and soluble Steel Factor correlates with leukemic potential Blood. 96: 3734-3742. DOI: 10.1182/Blood.V96.12.3734.H8003734_3734_3742  0.303
2000 Williams DA, Yang F-, Borneo JB, Pennington J, King AJ. Role of rac 2 in hemopoietic stem cell motility Experimental Hematology. 28: 128-129. DOI: 10.1016/S0301-472X(00)00497-5  0.343
2000 Yang F, Atkinson SJ, Borneo JB, Pennington J, Williams DA. The hematopoietic-specific rho gtpase, RAC2, is essential for normal adhesion and controlled movement of hematopoietic progenitor cells In vitro And In vivo Experimental Hematology. 28: 67-68. DOI: 10.1016/S0301-472X(00)00299-X  0.339
2000 Yang F, Kapur R, King A, Tao W, Borneo J, Williams D. RAC2 Regulates the activation of akt and the balance between pro- and anti-apoptotic proteins bad and bcl-xl Experimental Hematology. 28: 67. DOI: 10.1016/S0301-472X(00)00298-8  0.326
2000 Williams DA. Cells and Genes in Molecular Therapeutics Cell. 101: 145-146. DOI: 10.1016/S0092-8674(00)80821-1  0.376
1999 Williams DA. Retroviral-fibronectin interactions in transduction of mammalian cells Annals of the New York Academy of Sciences. 872: 109-114. PMID 10372115 DOI: 10.1111/J.1749-6632.1999.Tb08457.X  0.323
1999 Sellers SE, Tisdale JF, Bodine DM, Williams DA, Karlsson S, Meztger M, Donahue RE, Dunbar CE. No discrepancy between in vivo gene marking efficiency assessed in peripheral blood populations compared with bone marrow progenitors or CD34+ cells Human Gene Therapy. 10: 633-640. PMID 10094206 DOI: 10.1089/10430349950018706  0.343
1999 Roberts AW, Kim C, Zhen L, Lowe JB, Kapur R, Petryniak B, Spaetti A, Pollock JD, Borneo JB, Bradford GB, Atkinson SJ, Dinauer MC, Williams DA. Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense. Immunity. 10: 183-96. PMID 10072071 DOI: 10.1016/S1074-7613(00)80019-9  0.316
1999 Kapur R, Cooper R, Xiao X, Weiss MJ, Donovan P, Williams DA. The Presence of Novel Amino Acids in the Cytoplasmic Domain of Stem Cell Factor Results in Hematopoietic Defects inSteel17H Mice Blood. 94: 1915-1925. DOI: 10.1182/Blood.V94.6.1915  0.337
1999 MacNeill EC, Hanenberg H, Pollok KE, van der Loo JCM, Bierhuizen MFA, Wagemaker G, Williams DA. Simultaneous Infection with Retroviruses Pseudotyped with Different Envelope Proteins Bypasses Viral Receptor Interference Associated with Colocalization of gp70 and Target Cells on Fibronectin CH-296 Journal of Virology. 73: 3960-3967. DOI: 10.1128/Jvi.73.5.3960-3967.1999  0.305
1998 van der Loo JC, Xiao X, McMillin D, Hashino K, Kato I, Williams DA. VLA-5 is expressed by mouse and human long-term repopulating hematopoietic cells and mediates adhesion to extracellular matrix protein fibronectin. The Journal of Clinical Investigation. 102: 1051-61. PMID 9727075 DOI: 10.1172/Jci3687  0.332
1998 Du X, Williams DA. Update on development of interleukin-11. Current Opinion in Hematology. 2: 182-8. PMID 9371993 DOI: 10.1097/00062752-199502030-00005  0.342
1998 Veena P, Traycoff CM, Williams DA, McMahel J, Rice S, Cornetta K, Srour EF. Delayed Targeting of Cytokine-Nonresponsive Human Bone Marrow CD34+ Cells With Retrovirus-Mediated Gene Transfer Enhances Transduction Efficiency and Long-Term Expression of Transduced Genes Blood. 91: 3693-3701. DOI: 10.1182/Blood.V91.10.3693  0.31
1997 Longley BJ, Tyrrell L, Ma Y, Williams DA, Halaban R, Langley K, Lu HS, Schechter NM. Chymase cleavage of stem cell factor yields a bioactive, soluble product. Proceedings of the National Academy of Sciences of the United States of America. 94: 9017-21. PMID 9256427 DOI: 10.1073/Pnas.94.17.9017  0.32
1997 Kapur R, Everett ET, Uffman J, McAndrews-Hill M, Cooper R, Ryder J, Vik T, Williams DA. Overexpression of Human Stem Cell Factor Impairs Melanocyte, Mast Cell, and Thymocyte Development: A Role for Receptor Tyrosine Kinase-Mediated Mitogen Activated Protein Kinase Activation in Cell Differentiation Blood. 90: 3018-3026. DOI: 10.1182/Blood.V90.8.3018  0.324
1996 Larochelle A, Vormoor J, Hanenberg H, Wang JCY, Bhatia M, Lapidot T, Moritz T, Murdoch B, Xiao XL, Kato I, Williams DA, Dick JE. Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: Implications for gene therapy Nature Medicine. 2: 1329-1337. PMID 8946831 DOI: 10.1038/Nm1296-1329  0.353
1996 Hanenberg H, Xiao XL, Dilloo D, Hashino K, Kato I, Williams DA. Colocalization of retrovirus and target cells on specific fibronectin fragments increases genetic transduction of mammalian cells. Nature Medicine. 2: 876-82. PMID 8705856 DOI: 10.1038/Nm0896-876  0.332
1996 Maze R, Carney JP, Kelley MR, Glassner BJ, Williams DA, Samson L. Increasing DNA repair methyltransferase levels via bone marrow stem cell transduction rescues mice from the toxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic alkylating agent Proceedings of the National Academy of Sciences of the United States of America. 93: 206-210. PMID 8552605 DOI: 10.1073/Pnas.93.1.206  0.659
1996 Rackoff W, Orazi A, Robinson C, Cooper R, Alter B, Freedman M, Harris R, Williams D. Prolonged administration of granulocyte colony-stimulating factor (filgrastim) to patients with Fanconi anemia: a pilot study Blood. 88: 1588-1593. DOI: 10.1182/Blood.V88.5.1588.1588  0.3
1996 Moritz T, Dutt P, Xiao X, Carstanjen D, Vik T, Hanenberg H, Williams D. Fibronectin improves transduction of reconstituting hematopoietic stem cells by retroviral vectors: evidence of direct viral binding to chymotryptic carboxy-terminal fragments Blood. 88: 855-862. DOI: 10.1182/Blood.V88.3.855.Bloodjournal883855  0.352
1996 Majumdar M, Everett E, Xiao X, Cooper R, Langley K, Kapur R, Vik T, Williams D. Xenogeneic expression of human stem cell factor in transgenic mice mimics codominant c-kit mutations Blood. 87: 3203-3211. DOI: 10.1182/Blood.V87.8.3203.Bloodjournal8783203  0.313
1995 Williams DA, Moritz T. Genetic manipulation of hematopoietic stem cells in adenosine deaminase deficiency. Advances in Experimental Medicine and Biology. 370: 395-400. PMID 7660937 DOI: 10.1007/978-1-4615-2584-4_86  0.334
1995 Yoder M, King B, Hiatt K, Williams D. Murine embryonic yolk sac cells promote in vitro proliferation of bone marrow high proliferative potential colony-forming cells Blood. 86: 1322-1330. DOI: 10.1182/Blood.V86.4.1322.Bloodjournal8641322  0.322
1995 Du X, Scott D, Yang Z, Cooper R, Xiao X, Williams D. Interleukin-11 stimulates multilineage progenitors, but not stem cells, in murine and human long-term marrow cultures Blood. 86: 128-134. DOI: 10.1182/Blood.V86.1.128.Bloodjournal861128  0.311
1994 Moritz T, Patel VP, Williams DA. Bone marrow extracellular matrix molecules improve gene transfer into human hematopoietic cells via retroviral vectors. The Journal of Clinical Investigation. 93: 1451-7. PMID 8163649 DOI: 10.1172/Jci117122  0.344
1994 Yoder M, Papaioannou V, Breitfeld P, Williams D. Murine yolk sac endoderm- and mesoderm-derived cell lines support in vitro growth and differentiation of hematopoietic cells Blood. 83: 2436-2443. DOI: 10.1182/Blood.V83.9.2436.2436  0.336
1993 Bodine DM, Moritz T, Donahue RE, Luskey BD, Kessler SW, Martin DI, Orkin SH, Nienhuis AW, Williams DA. Long-term in vivo expression of a murine adenosine deaminase gene in rhesus monkey hematopoietic cells of multiple lineages after retroviral mediated gene transfer into CD34+ bone marrow cells. Blood. 82: 1975-80. PMID 7691243 DOI: 10.1182/Blood.V82.7.1975.Bloodjournal8271975  0.367
1993 Yoder M, Du X, Williams D. High proliferative potential colony-forming cell heterogeneity identified using counterflow centrifugal elutriation Blood. 82: 385-391. DOI: 10.1182/Blood.V82.2.385.Bloodjournal822385  0.315
1992 Toksoz D, Zsebo KM, Smith KA, Hu S, Brankow D, Suggs SV, Martin FH, Williams DA. Support of human hematopoiesis in long-term bone marrow cultures by murine stromal cells selectively expressing the membrane-bound and secreted forms of the human homolog of the steel gene product, stem cell factor. Proceedings of the National Academy of Sciences of the United States of America. 89: 7350-4. PMID 1380155 DOI: 10.1073/Pnas.89.16.7350  0.348
1992 Sieff CA, Yokoyama CT, Zsebo KM, Trammell J, Andersen JW, Nathan DG, Williams DA. The production of steel factor mRNA in Diamond-Blackfan anaemia long-term cultures and interactions of steel factor with erythropoietin and interleukin-3. British Journal of Haematology. 82: 640-7. PMID 1282827 DOI: 10.1111/J.1365-2141.1992.Tb06938.X  0.307
1992 Luskey B, Rosenblatt M, Zsebo K, Williams D. Stem cell factor, interleukin-3, and interleukin-6 promote retroviral- mediated gene transfer into murine hematopoietic stem cells Blood. 80: 396-402. DOI: 10.1182/Blood.V80.2.396.Bloodjournal802396  0.307
1991 Luskey BD, Lim B, Apperley JF, Orkin SH, Williams DA. Gene transfer into murine hematopoietic stem cells and bone marrow stromal cells. Annals of the New York Academy of Sciences. 612: 398-406. PMID 2291566 DOI: 10.1111/J.1749-6632.1990.Tb24327.X  0.361
1991 Williams DA, Rios M, Stephens C, Patel VP. Fibronectin and VLA-4 in haematopoietic stem cell-microenvironment interactions. Nature. 352: 438-41. PMID 1861722 DOI: 10.1038/352438A0  0.32
1991 Apperley J, Luskey B, Williams D. Retroviral gene transfer of human adenosine deaminase in murine hematopoietic cells: effect of selectable marker sequences on long-term expression Blood. 78: 310-317. DOI: 10.1182/Blood.V78.2.310.Bloodjournal782310  0.353
1991 Paul S, Yang Y, Donahue R, Goldring S, Williams D. Stromal cell-associated hematopoiesis: immortalization and characterization of a primate bone marrow-derived stromal cell line Blood. 77: 1723-1733. DOI: 10.1182/Blood.V77.8.1723.Bloodjournal7781723  0.338
1990 Apperley JF, Williams DA. Gene therapy: current status and future directions. British Journal of Haematology. 75: 148-55. PMID 2196929 DOI: 10.1111/J.1365-2141.1990.Tb02641.X  0.316
1990 Paul SR, Bennett F, Calvetti JA, Kelleher K, Wood CR, O'Hara RM, Leary AC, Sibley B, Clark SC, Williams DA. Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine. Proceedings of the National Academy of Sciences of the United States of America. 87: 7512-6. PMID 2145578 DOI: 10.1073/Pnas.87.19.7512  0.317
1990 Williams DA. Expression of introduced genetic sequences in hematopoietic cells following retroviral-mediated gene transfer Human Gene Therapy. 1: 229-239. PMID 1964394 DOI: 10.1089/Hum.1990.1.3-229  0.351
1990 Rios M, Williams DA. Systematic analysis of the ability of stromal cell lines derived from different murine adult tissues to support maintenance of hematopoietic stem cells in vitro Journal of Cellular Physiology. 145: 434-443. PMID 1703166 DOI: 10.1002/Jcp.1041450307  0.349
1990 Zsebo KM, Williams DA, Geissler EN, Broudy VC, Martin FH, Atkins HL, Hsu RY, Birkett NC, Okino KH, Murdock DC. Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor. Cell. 63: 213-24. PMID 1698556 DOI: 10.1016/0092-8674(90)90302-U  0.309
1990 Corey C, DeSilva A, Holland C, Williams D. Serial transplantation of methotrexate-resistant bone marrow: protection of murine recipients from drug toxicity by progeny of transduced stem cells Blood. 75: 337-343. DOI: 10.1182/Blood.V75.2.337.Bloodjournal752337  0.356
1989 Lim B, Apperley JF, Orkin SH, Williams DA. Long-term expression of human adenosine deaminase in mice transplanted with retrovirus-infected hematopoietic stem cells Proceedings of the National Academy of Sciences of the United States of America. 86: 8892-8896. PMID 2573068 DOI: 10.1073/Pnas.86.22.8892  0.339
1988 Williams DA, Rosenblatt MF, Beier DR, Cone RD. Generation of murine stromal cell lines supporting hematopoietic stem cell proliferation by use of recombinant retrovirus vectors encoding simian virus 40 large T antigen. Molecular and Cellular Biology. 8: 3864-71. PMID 2851729 DOI: 10.1128/Mcb.8.9.3864  0.583
1988 Williams D, Lim B, Spooncer E, Longtine J, Dexter T. Restriction of expression of an integrated recombinant retrovirus in primary but not immortalized murine hematopoietic stem cells. Blood. 71: 1738-1743. DOI: 10.1182/Blood.V71.6.1738.Bloodjournal7161738  0.323
1988 Williams DA. Gene Transfer and the Prospects for Somatic Gene Therapy Hematology/Oncology Clinics of North America. 2: 277-287. DOI: 10.1016/S0889-8588(18)30621-X  0.305
1987 Lim B, Williams DA, Orkin SH. Retrovirus-mediated gene transfer of human adenosine deaminase: expression of functional enzyme in murine hematopoietic stem cells in vivo Molecular and Cellular Biology. 7: 3459-3465. PMID 3683389 DOI: 10.1128/Mcb.7.10.3459  0.326
1987 Williams DA, Hsieh K, DeSilva A, Mulligan RC. Protection of bone marrow transplant recipients from lethal doses of methotrexate by the generation of methotrexate-resistant bone marrow. The Journal of Experimental Medicine. 166: 210-8. PMID 3298524 DOI: 10.1084/Jem.166.1.210  0.553
1986 Williams DA, Orkin SH, Mulligan RC. Retrovirus-mediated transfer of human adenosine deaminase gene sequences into cells in culture and into murine hematopoietic cells in vivo. Proceedings of the National Academy of Sciences of the United States of America. 83: 2566-70. PMID 3458218 DOI: 10.1073/Pnas.83.8.2566  0.525
1984 Williams DA, Lemischka IR, Nathan DG, Mulligan RC. Introduction of new genetic material into pluripotent haematopoietic stem cells of the mouse. Nature. 310: 476-80. PMID 6087158 DOI: 10.1038/310476A0  0.661
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