Andrew M. Gulick, Ph.D. - Publications

Structural Biology Hauptman-Woodward Medical Research Institute 

67 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Gulick AM, Aldrich CC. Trapping interactions between catalytic domains and carrier proteins of modular biosynthetic enzymes with chemical probes. Natural Product Reports. PMID 30046790 DOI: 10.1039/c8np00044a  1
2018 Ray S, Kreitler DF, Gulick AM, Murkin AS. The Nitro Group as a Masked Electrophile in Covalent Enzyme Inhibition. Acs Chemical Biology. PMID 29782144 DOI: 10.1021/acschembio.8b00225  1
2018 Bailey DC, Alexander E, Rice MR, Drake EJ, Mydy LS, Aldrich CC, Gulick AM. Structural and functional delineation of aerobactin biosynthesis in hypervirulent . The Journal of Biological Chemistry. PMID 29618511 DOI: 10.1074/jbc.RA118.002798  1
2017 Clevenger KD, Mascarenhas R, Catlin D, Wu R, Kelleher NL, Drake EJ, Gulick AM, Liu D, Fast W. Substrate Trapping in the Siderophore Tailoring Enzyme PvdQ. Acs Chemical Biology. PMID 28186406 DOI: 10.1021/acschembio.7b00031  1
2016 Branchini BR, Southworth TL, Fontaine DM, Murtiashaw MH, McGurk A, Talukder MH, Qureshi R, Yetil D, Sundlov JA, Gulick AM. Cloning of the Orange Light-Producing Luciferase from Photinus scintillans - A New Proposal on how Bioluminescence Color is Determined. Photochemistry and Photobiology. PMID 27861940 DOI: 10.1111/php.12671  1
2016 Miller BR, Drake EJ, Shi C, Aldrich CC, Gulick AM. Structures of a Nonribosomal Peptide Synthetase Module Bound to MbtH-Like Proteins Support a Highly Dynamic Domain Architecture. The Journal of Biological Chemistry. PMID 27597544 DOI: 10.1074/jbc.M116.746297  1
2016 Meneely KM, Sundlov JA, Gulick AM, Moran GR, Lamb AL. An Open and Shut Case: The Interaction of Magnesium with MST Enzymes. Journal of the American Chemical Society. PMID 27373320 DOI: 10.1021/jacs.6b05134  1
2016 Bailey DC, Drake EJ, Grant TD, Gulick AM. Structural and functional characterization of aerobactin synthetase IucA from a hypervirulent pathotype of Klebsiella pneumoniae. Biochemistry. PMID 27253399 DOI: 10.1021/acs.biochem.6b00409  1
2016 Richard JP, Amyes TL, Malabanan MM, Zhai X, Kim KJ, Reinhardt CJ, Wierenga RK, Drake EJ, Gulick AM. Structure-Function Studies on Hydrophobic Residues that Clamp a Basic Glutamate Side-Chain During Catalysis by Triosephosphate Isomerase. Biochemistry. PMID 27149328 DOI: 10.1021/acs.biochem.6b00311  1
2016 Drake EJ, Gulick AM. 1.2 Å resolution crystal structure of the periplasmic aminotransferase PvdN from Pseudomonas aeruginosa. Acta Crystallographica. Section F, Structural Biology Communications. 72: 403-8. PMID 27139833 DOI: 10.1107/S2053230X16006257  1
2016 Miller BR, Gulick AM. Structural Biology of Nonribosomal Peptide Synthetases. Methods in Molecular Biology (Clifton, N.J.). 1401: 3-29. PMID 26831698 DOI: 10.1007/978-1-4939-3375-4_1  1
2016 Drake EJ, Miller BR, Shi C, Tarrasch JT, Sundlov JA, Allen CL, Skiniotis G, Aldrich CC, Gulick AM. Structures of two distinct conformations of holo-non-ribosomal peptide synthetases. Nature. 529: 235-8. PMID 26762461 DOI: 10.1038/nature16163  1
2015 Branchini BR, Behney CE, Southworth TL, Fontaine DM, Gulick AM, Vinyard DJ, Brudvig GW. Experimental Support for a Single Electron-Transfer Oxidation Mechanism in Firefly Bioluminescence. Journal of the American Chemical Society. 137: 7592-5. PMID 26057379 DOI: 10.1021/jacs.5b03820  1
2015 Zhu J, Lippa GM, Gulick AM, Tipton PA. Examining Reaction Specificity in PvcB, a Source of Diversity in Isonitrile-Containing Natural Products. Biochemistry. 54: 2659-69. PMID 25866990 DOI: 10.1021/acs.biochem.5b00255  1
2015 Kholodar SA, Allen CL, Gulick AM, Murkin AS. The role of phosphate in a multistep enzymatic reaction: reactions of the substrate and intermediate in pieces. Journal of the American Chemical Society. 137: 2748-56. PMID 25642788 DOI: 10.1021/ja512911f  1
2015 Mitchell CA, Tucker AC, Escalante-Semerena JC, Gulick AM. The structure of S. lividans acetoacetyl-CoA synthetase shows a novel interaction between the C-terminal extension and the N-terminal domain. Proteins. 83: 575-81. PMID 25488501 DOI: 10.1002/prot.24738  1
2014 Miller BR, Sundlov JA, Drake EJ, Makin TA, Gulick AM. Analysis of the linker region joining the adenylation and carrier protein domains of the modular nonribosomal peptide synthetases. Proteins. 82: 2691-702. PMID 24975514 DOI: 10.1002/prot.24635  1
2014 Allen CL, Gulick AM. Structural and bioinformatic characterization of an Acinetobacter baumannii type II carrier protein. Acta Crystallographica. Section D, Biological Crystallography. 70: 1718-25. PMID 24914982 DOI: 10.1107/S1399004714008311  1
2014 Kholodar SA, Tombline G, Liu J, Tan Z, Allen CL, Gulick AM, Murkin AS. Alteration of the flexible loop in 1-deoxy-D-xylulose-5-phosphate reductoisomerase boosts enthalpy-driven inhibition by fosmidomycin. Biochemistry. 53: 3423-31. PMID 24825256 DOI: 10.1021/bi5004074  1
2014 Wurst JM, Drake EJ, Theriault JR, Jewett IT, VerPlank L, Perez JR, Dandapani S, Palmer M, Moskowitz SM, Schreiber SL, Munoz B, Gulick AM. Identification of inhibitors of PvdQ, an enzyme involved in the synthesis of the siderophore pyoverdine. Acs Chemical Biology. 9: 1536-44. PMID 24824984 DOI: 10.1021/cb5001586  1
2014 Russo TA, Olson R, Macdonald U, Metzger D, Maltese LM, Drake EJ, Gulick AM. Aerobactin mediates virulence and accounts for increased siderophore production under iron-limiting conditions by hypervirulent (hypermucoviscous) Klebsiella pneumoniae. Infection and Immunity. 82: 2356-67. PMID 24664504 DOI: 10.1128/IAI.01667-13  1
2013 Sundlov JA, Gulick AM. Structure determination of the functional domain interaction of a chimeric nonribosomal peptide synthetase from a challenging crystal with noncrystallographic translational symmetry. Acta Crystallographica. Section D, Biological Crystallography. 69: 1482-92. PMID 23897471 DOI: 10.1107/S0907444913009372  1
2013 Demonte D, Drake EJ, Lim KH, Gulick AM, Park S. Structure-based engineering of streptavidin monomer with a reduced biotin dissociation rate. Proteins. 81: 1621-33. PMID 23670729 DOI: 10.1002/prot.24320  1
2013 Neres J, Engelhart CA, Drake EJ, Wilson DJ, Fu P, Boshoff HI, Barry CE, Gulick AM, Aldrich CC. Non-nucleoside inhibitors of BasE, an adenylating enzyme in the siderophore biosynthetic pathway of the opportunistic pathogen Acinetobacter baumannii. Journal of Medicinal Chemistry. 56: 2385-405. PMID 23437866 DOI: 10.1021/jm301709s  1
2013 Tessier MB, Grant OC, Heimburg-Molinaro J, Smith D, Jadey S, Gulick AM, Glushka J, Deutscher SL, Rittenhouse-Olson K, Woods RJ. Computational screening of the human TF-glycome provides a structural definition for the specificity of anti-tumor antibody JAA-F11. Plos One. 8: e54874. PMID 23365681 DOI: 10.1371/journal.pone.0054874  1
2013 Wilson DJ, Shi C, Teitelbaum AM, Gulick AM, Aldrich CC. Characterization of AusA: a dimodular nonribosomal peptide synthetase responsible for the production of aureusimine pyrazinones. Biochemistry. 52: 926-37. PMID 23302043 DOI: 10.1021/bi301330q  1
2012 Muppidi A, Doi K, Edwardraja S, Drake EJ, Gulick AM, Wang HG, Lin Q. Rational design of proteolytically stable, cell-permeable peptide-based selective Mcl-1 inhibitors. Journal of the American Chemical Society. 134: 14734-7. PMID 22920569 DOI: 10.1021/ja306864v  1
2012 Sundlov JA, Fontaine DM, Southworth TL, Branchini BR, Gulick AM. Crystal structure of firefly luciferase in a second catalytic conformation supports a domain alternation mechanism. Biochemistry. 51: 6493-5. PMID 22852753 DOI: 10.1021/bi300934s  1
2012 Mitchell CA, Shi C, Aldrich CC, Gulick AM. Structure of PA1221, a nonribosomal peptide synthetase containing adenylation and peptidyl carrier protein domains. Biochemistry. 51: 3252-63. PMID 22452656 DOI: 10.1021/bi300112e  1
2012 Sundlov JA, Shi C, Wilson DJ, Aldrich CC, Gulick AM. Structural and functional investigation of the intermolecular interaction between NRPS adenylation and carrier protein domains. Chemistry & Biology. 19: 188-98. PMID 22365602 DOI: 10.1016/j.chembiol.2011.11.013  1
2011 Drake EJ, Gulick AM. Structural characterization and high-throughput screening of inhibitors of PvdQ, an NTN hydrolase involved in pyoverdine synthesis. Acs Chemical Biology. 6: 1277-86. PMID 21892836 DOI: 10.1021/cb2002973  1
2010 Drake EJ, Duckworth BP, Neres J, Aldrich CC, Gulick AM. Biochemical and structural characterization of bisubstrate inhibitors of BasE, the self-standing nonribosomal peptide synthetase adenylate-forming enzyme of acinetobactin synthesis. Biochemistry. 49: 9292-305. PMID 20853905 DOI: 10.1021/bi101226n  1
2009 Sundlov JA, Gulick AM. Insights into resistance against lincosamide antibiotics. Structure (London, England : 1993). 17: 1549-50. PMID 20004157 DOI: 10.1016/j.str.2009.11.001  1
2009 Gulick AM. Conformational dynamics in the Acyl-CoA synthetases, adenylation domains of non-ribosomal peptide synthetases, and firefly luciferase. Acs Chemical Biology. 4: 811-27. PMID 19610673 DOI: 10.1021/cb900156h  1
2009 Shah MB, Ingram-Smith C, Cooper LL, Qu J, Meng Y, Smith KS, Gulick AM. The 2.1 A crystal structure of an acyl-CoA synthetase from Methanosarcina acetivorans reveals an alternate acyl-binding pocket for small branched acyl substrates. Proteins. 77: 685-98. PMID 19544569 DOI: 10.1002/prot.22482  1
2009 Wu R, Reger AS, Lu X, Gulick AM, Dunaway-Mariano D. The mechanism of domain alternation in the acyl-adenylate forming ligase superfamily member 4-chlorobenzoate: coenzyme A ligase. Biochemistry. 48: 4115-25. PMID 19320426 DOI: 10.1021/bi9002327  1
2009 Gulick AM. Ironing out a new siderophore synthesis strategy. Nature Chemical Biology. 5: 143-4. PMID 19219015 DOI: 10.1038/nchembio0309-143  1
2008 Drake EJ, Gulick AM. Three-dimensional structures of Pseudomonas aeruginosa PvcA and PvcB, two proteins involved in the synthesis of 2-isocyano-6,7-dihydroxycoumarin. Journal of Molecular Biology. 384: 193-205. PMID 18824174 DOI: 10.1016/j.jmb.2008.09.027  1
2008 Wu R, Cao J, Lu X, Reger AS, Gulick AM, Dunaway-Mariano D. Mechanism of 4-chlorobenzoate:coenzyme a ligase catalysis. Biochemistry. 47: 8026-39. PMID 18620421 DOI: 10.1021/bi800698m  1
2008 Reger AS, Wu R, Dunaway-Mariano D, Gulick AM. Structural characterization of a 140 degrees domain movement in the two-step reaction catalyzed by 4-chlorobenzoate:CoA ligase. Biochemistry. 47: 8016-25. PMID 18620418 DOI: 10.1021/bi800696y  1
2007 Wu R, Reger AS, Cao J, Gulick AM, Dunaway-Mariano D. Rational redesign of the 4-chlorobenzoate binding site of 4-chlorobenzoate: coenzyme a ligase for expanded substrate range. Biochemistry. 46: 14487-99. PMID 18027984 DOI: 10.1021/bi701609w  1
2007 Drake EJ, Cao J, Qu J, Shah MB, Straubinger RM, Gulick AM. The 1.8 A crystal structure of PA2412, an MbtH-like protein from the pyoverdine cluster of Pseudomonas aeruginosa. The Journal of Biological Chemistry. 282: 20425-34. PMID 17502378 DOI: 10.1074/jbc.M611833200  1
2007 Reger AS, Carney JM, Gulick AM. Biochemical and crystallographic analysis of substrate binding and conformational changes in acetyl-CoA synthetase. Biochemistry. 46: 6536-46. PMID 17497934 DOI: 10.1021/bi6026506  1
2006 Sundlov JA, Garringer JA, Carney JM, Reger AS, Drake EJ, Duax WL, Gulick AM. Determination of the crystal structure of EntA, a 2,3-dihydro-2,3-dihydroxybenzoic acid dehydrogenase from Escherichia coli. Acta Crystallographica. Section D, Biological Crystallography. 62: 734-40. PMID 16790929 DOI: 10.1107/S0907444906015824  1
2006 Drake EJ, Nicolai DA, Gulick AM. Structure of the EntB multidomain nonribosomal peptide synthetase and functional analysis of its interaction with the EntE adenylation domain. Chemistry & Biology. 13: 409-19. PMID 16632253 DOI: 10.1016/j.chembiol.2006.02.005  1
2005 Wang Y, Feng L, Said M, Balderman S, Fayazi Z, Liu Y, Ghosh D, Gulick AM. Analysis of the 2.0 A crystal structure of the protein-DNA complex of the human PDEF Ets domain bound to the prostate specific antigen regulatory site. Biochemistry. 44: 7095-106. PMID 15882048 DOI: 10.1021/bi047352t  1
2004 Gulick AM, Lu X, Dunaway-Mariano D. Crystal structure of 4-chlorobenzoate:CoA ligase/synthetase in the unliganded and aryl substrate-bound states. Biochemistry. 43: 8670-9. PMID 15236575 DOI: 10.1021/bi049384m  1
2003 Gulick AM, Starai VJ, Horswill AR, Homick KM, Escalante-Semerena JC. The 1.75 A crystal structure of acetyl-CoA synthetase bound to adenosine-5'-propylphosphate and coenzyme A. Biochemistry. 42: 2866-73. PMID 12627952 DOI: 10.1021/bi0271603  1
2002 Gulick AM, Horswill AR, Thoden JB, Escalante-Semerena JC, Rayment I. Pentaerythritol propoxylate: a new crystallization agent and cryoprotectant induces crystal growth of 2-methylcitrate dehydratase. Acta Crystallographica. Section D, Biological Crystallography. 58: 306-9. PMID 11807258 DOI: 10.1107/S0907444901018832  1
2001 Gulick AM, Schmidt DM, Gerlt JA, Rayment I. Evolution of enzymatic activities in the enolase superfamily: crystal structures of the L-Ala-D/L-Glu epimerases from Escherichia coli and Bacillus subtilis. Biochemistry. 40: 15716-24. PMID 11747448 DOI: 10.1021/bi011641p  1
2001 Gulick AM, Hubbard BK, Gerlt JA, Rayment I. Evolution of enzymatic activities in the enolase superfamily: identification of the general acid catalyst in the active site of D-glucarate dehydratase from Escherichia coli. Biochemistry. 40: 10054-62. PMID 11513584 DOI: 10.1021/bi010733b  1
2000 Gulick AM, Hubbard BK, Gerlt JA, Rayment I. Evolution of enzymatic activities in the enolase superfamily: crystallographic and mutagenesis studies of the reaction catalyzed by D-glucarate dehydratase from Escherichia coli. Biochemistry. 39: 4590-602. PMID 10769114 DOI: 10.1021/bi992782i  1
2000 Gulick AM, Bauer CB, Thoden JB, Pate E, Yount RG, Rayment I. X-ray structures of the Dictyostelium discoideum myosin motor domain with six non-nucleotide analogs. The Journal of Biological Chemistry. 275: 398-408. PMID 10617631 DOI: 10.1074/jbc.275.1.398  1
1998 Gulick AM, Palmer DR, Babbitt PC, Gerlt JA, Rayment I. Evolution of enzymatic activities in the enolase superfamily: crystal structure of (D)-glucarate dehydratase from Pseudomonas putida. Biochemistry. 37: 14358-68. PMID 9772161 DOI: 10.1021/bi981123n  1
1998 Gulick AM, Song H, Endow SA, Rayment I. X-ray crystal structure of the yeast Kar3 motor domain complexed with Mg.ADP to 2.3 A resolution. Biochemistry. 37: 1769-76. PMID 9485302 DOI: 10.1021/bi972504o  1
1997 Gulick AM, Bauer CB, Thoden JB, Rayment I. X-ray structures of the MgADP, MgATPgammaS, and MgAMPPNP complexes of the Dictyostelium discoideum myosin motor domain. Biochemistry. 36: 11619-28. PMID 9305951 DOI: 10.1021/bi9712596  1
1997 Thoden JB, Gulick AM, Holden HM. Molecular structures of the S124A, S124T, and S124V site-directed mutants of UDP-galactose 4-epimerase from Escherichia coli. Biochemistry. 36: 10685-95. PMID 9271499 DOI: 10.1021/bi9704313  1
1997 Liu Y, Thoden JB, Kim J, Berger E, Gulick AM, Ruzicka FJ, Holden HM, Frey PA. Mechanistic roles of tyrosine 149 and serine 124 in UDP-galactose 4-epimerase from Escherichia coli. Biochemistry. 36: 10675-84. PMID 9271498 DOI: 10.1021/bi970430a  1
1997 Manoharan HT, Gallo J, Gulick AM, Fahl WE. High-level production and purification of biologically active proteins from bacterial and mammalian cells using the tandem pGFLEX expression system. Gene. 193: 229-37. PMID 9256081 DOI: 10.1016/S0378-1119(97)00126-1  1
1997 Gulick AM, Rayment I. Structural studies on myosin II: communication between distant protein domains. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 19: 561-9. PMID 9230689 DOI: 10.1002/bies.950190707  1
1997 Rayment I, Gulick AM, Bauer CB. Myosin based motuity-structural studios of the dictyostelium discoideum myosin motor domain Faseb Journal. 11: A863.  1
1995 Gulick AM, Fahl WE. Mammalian glutathione S-transferase: regulation of an enzyme system to achieve chemotherapeutic efficacy. Pharmacology & Therapeutics. 66: 237-57. PMID 7667397 DOI: 10.1016/0163-7258(94)00079-I  1
1995 Gulick AM, Fahl WE. Forced evolution of glutathione S-transferase to create a more efficient drug detoxication enzyme. Proceedings of the National Academy of Sciences of the United States of America. 92: 8140-4. PMID 7667259 DOI: 10.1073/pnas.92.18.8140  1
1992 Manoharan TH, Gulick AM, Reinemer P, Dirr HW, Huber R, Fahl WE. Mutational substitution of residues implicated by crystal structure in binding the substrate glutathione to human glutathione S-transferase pi. Journal of Molecular Biology. 226: 319-22. PMID 1640452 DOI: 10.1016/0022-2836(92)90949-K  1
1992 Gulick AM, Goihl AL, Fahl WE. Structural studies on human glutathione S-transferase pi. Family of native-specific monoclonal antibodies used to block catalysis. The Journal of Biological Chemistry. 267: 18946-52. PMID 1527022  1
1992 Manoharan TH, Gulick AM, Puchalski RB, Servais AL, Fahl WE. Structural studies on human glutathione S-transferase pi. Substitution mutations to determine amino acids necessary for binding glutathione. The Journal of Biological Chemistry. 267: 18940-5. PMID 1527021  1
1991 Manoharan TH, Welch PJ, Gulick AM, Puchalski RB, Lathrop AL, Fahl WE. Expression of tandem glutathione S-transferase recombinant genes in COS cells for analysis of efficiency of protein expression and associated drug resistance. Molecular Pharmacology. 39: 461-7. PMID 1850090  1
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