Terry D. Butters - Publications

Oxford Glycobiology Institute University of Cambridge, Cambridge, England, United Kingdom 

116 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 DeWald LE, Starr C, Butters T, Treston A, Warfield KL. Iminosugars: a host-targeted approach to combat Flaviviridae infections. Antiviral Research. 184: 104881. PMID 32768411 DOI: 10.1016/J.Antiviral.2020.104881  0.369
2018 Link-Lenczowski P, Bubka M, Balog CIA, Koeleman CAM, Butters TD, Wuhrer M, Lityńska A. The glycomic effect of N-acetylglucosaminyltransferase III overexpression in metastatic melanoma cells. GnT-III modifies highly branched N-glycans. Glycoconjugate Journal. PMID 29502191 DOI: 10.1007/S10719-018-9814-Y  0.38
2016 Glawar AF, Martínez RF, Ayers BJ, Hollas MA, Ngo N, Nakagawa S, Kato A, Butters TD, Fleet GW, Jenkinson SF. Structural essentials for β-N-acetylhexosaminidase inhibition by amides of prolines, pipecolic and azetidine carboxylic acids. Organic & Biomolecular Chemistry. PMID 27735004 DOI: 10.1039/C6Ob01549B  0.402
2015 Warfield KL, Plummer E, Alonzi DS, Wolfe GW, Sampath A, Nguyen T, Butters TD, Enterlein SG, Stavale EJ, Shresta S, Ramstedt U. A Novel Iminosugar UV-12 with Activity against the Diverse Viruses Influenza and Dengue (Novel Iminosugar Antiviral for Influenza and Dengue). Viruses. 7: 2404-27. PMID 25984714 DOI: 10.3390/V7052404  0.319
2015 Ersek A, Xu K, Antonopoulos A, Butters TD, Santo AE, Vattakuzhi Y, Williams LM, Goudevenou K, Danks L, Freidin A, Spanoudakis E, Parry S, Papaioannou M, Hatjiharissi E, Chaidos A, et al. Glycosphingolipid synthesis inhibition limits osteoclast activation and myeloma bone disease. The Journal of Clinical Investigation. 125: 2279-92. PMID 25915583 DOI: 10.1172/Jci59987  0.34
2015 Yákobovitz MK, Butters TD, Cohen E. Inhibition of α-glucosidase activity by N-deoxynojirimycin analogs in several insect phloem sap feeders. Insect Science. PMID 25900765 DOI: 10.1111/1744-7917.12229  0.399
2014 Aguilar AL, Escribano J, Wentworth P, Butters TD. Synthetic 1-deoxynojirimycin N-substituted peptides offer prolonged disruption to N-linked glycan processing. Chemmedchem. 9: 2809-13. PMID 25352425 DOI: 10.1002/Cmdc.201402186  0.392
2014 Désiré J, Mondon M, Fontelle N, Nakagawa S, Hirokami Y, Adachi I, Iwaki R, Fleet GW, Alonzi DS, Twigg G, Butters TD, Bertrand J, Cendret V, Becq F, Norez C, et al. N- and C-alkylation of seven-membered iminosugars generates potent glucocerebrosidase inhibitors and F508del-CFTR correctors. Organic & Biomolecular Chemistry. 12: 8977-96. PMID 25277226 DOI: 10.1039/C4Ob00325J  0.378
2014 Crabtree EV, Martínez RF, Nakagawa S, Adachi I, Butters TD, Kato A, Fleet GW, Glawar AF. Synthesis of the enantiomers of XYLNAc and LYXNAc: comparison of β-N-acetylhexosaminidase inhibition by the 8 stereoisomers of 2-N-acetylamino-1,2,4-trideoxy-1,4-iminopentitols. Organic & Biomolecular Chemistry. 12: 3932-43. PMID 24802185 DOI: 10.1039/C4Ob00097H  0.399
2014 Ayers BJ, Glawar AF, Martínez RF, Ngo N, Liu Z, Fleet GW, Butters TD, Nash RJ, Yu CY, Wormald MR, Nakagawa S, Adachi I, Kato A, Jenkinson SF. Nine of 16 stereoisomeric polyhydroxylated proline amides are potent β-N-acetylhexosaminidase inhibitors. The Journal of Organic Chemistry. 79: 3398-409. PMID 24641544 DOI: 10.1021/Jo500157P  0.394
2014 Joosten A, Decroocq C, de Sousa J, Schneider JP, Etamé E, Bodlenner A, Butters TD, Compain P. A systematic investigation of iminosugar click clusters as pharmacological chaperones for the treatment of Gaucher disease. Chembiochem : a European Journal of Chemical Biology. 15: 309-19. PMID 24375964 DOI: 10.1002/Cbic.201300442  0.347
2013 Compain P, Decroocq C, Joosten A, de Sousa J, Rodríguez-Lucena D, Butters TD, Bertrand J, Clément R, Boinot C, Becq F, Norez C. Rescue of functional CFTR channels in cystic fibrosis: a dramatic multivalent effect using iminosugar cluster-based correctors. Chembiochem : a European Journal of Chemical Biology. 14: 2050-8. PMID 24038832 DOI: 10.1002/Cbic.201300312  0.333
2013 Jenkinson SF, Best D, Saville AW, Mui J, Martínez RF, Nakagawa S, Kunimatsu T, Alonzi DS, Butters TD, Norez C, Becq F, Blériot Y, Wilson FX, Weymouth-Wilson AC, Kato A, et al. C-branched iminosugars: α-glucosidase inhibition by enantiomers of isoDMDP, isoDGDP, and isoDAB-L-isoDMDP compared to miglitol and miglustat. The Journal of Organic Chemistry. 78: 7380-97. PMID 23688199 DOI: 10.1021/Jo4005487  0.333
2013 Howe JD, Smith N, Lee MJ, Ardes-Guisot N, Vauzeilles B, Désiré J, Baron A, Blériot Y, Sollogoub M, Alonzi DS, Butters TD. Novel imino sugar α-glucosidase inhibitors as antiviral compounds. Bioorganic & Medicinal Chemistry. 21: 4831-8. PMID 23582447 DOI: 10.1016/J.Bmc.2013.03.014  0.352
2013 Chang J, Warren TK, Zhao X, Gill T, Guo F, Wang L, Comunale MA, Du Y, Alonzi DS, Yu W, Ye H, Liu F, Guo JT, Mehta A, Cuconati A, ... Butters TD, et al. Small molecule inhibitors of ER α-glucosidases are active against multiple hemorrhagic fever viruses. Antiviral Research. 98: 432-40. PMID 23578725 DOI: 10.1016/J.Antiviral.2013.03.023  0.326
2013 Alonzi DS, Kukushkin NV, Allman SA, Hakki Z, Williams SJ, Pierce L, Dwek RA, Butters TD. Glycoprotein misfolding in the endoplasmic reticulum: identification of released oligosaccharides reveals a second ER-associated degradation pathway for Golgi-retrieved proteins. Cellular and Molecular Life Sciences : Cmls. 70: 2799-814. PMID 23503623 DOI: 10.1007/S00018-013-1304-6  0.304
2013 Perry ST, Buck MD, Plummer EM, Penmasta RA, Batra H, Stavale EJ, Warfield KL, Dwek RA, Butters TD, Alonzi DS, Lada SM, King K, Klose B, Ramstedt U, Shresta S. An iminosugar with potent inhibition of dengue virus infection in vivo. Antiviral Research. 98: 35-43. PMID 23376501 DOI: 10.1016/J.Antiviral.2013.01.004  0.305
2012 Glawar AF, Best D, Ayers BJ, Miyauchi S, Nakagawa S, Aguilar-Moncayo M, García Fernández JM, Ortiz Mellet C, Crabtree EV, Butters TD, Wilson FX, Kato A, Fleet GW. Scalable syntheses of both enantiomers of DNJNAc and DGJNAc from glucuronolactone: the effect of N-alkylation on hexosaminidase inhibition. Chemistry (Weinheim An Der Bergstrasse, Germany). 18: 9341-59. PMID 22736508 DOI: 10.1002/Chem.201200110  0.411
2012 Kukushkin NV, Easthope IS, Alonzi DS, Butters TD. Restricted processing of glycans by endomannosidase in mammalian cells. Glycobiology. 22: 1282-8. PMID 22641772 DOI: 10.1093/Glycob/Cws088  0.373
2012 Trapero A, González-Bulnes P, Butters TD, Llebaria A. Potent aminocyclitol glucocerebrosidase inhibitors are subnanomolar pharmacological chaperones for treating gaucher disease. Journal of Medicinal Chemistry. 55: 4479-88. PMID 22512696 DOI: 10.1021/Jm300342Q  0.381
2012 Wang GN, Twigg G, Butters TD, Zhang S, Zhang L, Zhang LH, Ye XS. Synthesis of N-substituted ε-hexonolactams as pharmacological chaperones for the treatment of N370S mutant Gaucher disease. Organic & Biomolecular Chemistry. 10: 2923-7. PMID 22286559 DOI: 10.1039/C2Ob06987C  0.394
2012 Thompson AJ, Williams RJ, Hakki Z, Alonzi DS, Wennekes T, Gloster TM, Songsrirote K, Thomas-Oates JE, Wrodnigg TM, Spreitz J, Stütz AE, Butters TD, Williams SJ, Davies GJ. Structural and mechanistic insight into N-glycan processing by endo-α-mannosidase. Proceedings of the National Academy of Sciences of the United States of America. 109: 781-6. PMID 22219371 DOI: 10.1073/Pnas.1111482109  0.414
2012 Deschamp J, Mondon M, Nakagawa S, Kato A, Alonzi DS, Butters TD, Zhang Y, Sollogoub M, Blériot Y. Towards a stable noeuromycin analog with a D-manno configuration: synthesis and glycosidase inhibition of D-manno-like tri- and tetrahydroxylated azepanes. Bioorganic & Medicinal Chemistry. 20: 641-9. PMID 20971647 DOI: 10.1016/J.Bmc.2010.09.053  0.321
2012 Quach T, Tsegay S, Thompson AJ, Kukushkin NV, Alonzi DS, Butters TD, Davies GJ, Williams SJ. Fleetamine (3-O-α-d-glucopyranosyl-swainsonine): The synthesis of a hypothetical inhibitor of endo-α-mannosidase Tetrahedron Asymmetry. 23: 992-997. DOI: 10.1016/J.Tetasy.2012.06.011  0.353
2011 Cumpstey I, Frigell J, Pershagen E, Akhtar T, Moreno-Clavijo E, Robina I, Alonzi DS, Butters TD. Amine-linked diglycosides: Synthesis facilitated by the enhanced reactivity of allylic electrophiles, and glycosidase inhibition assays. Beilstein Journal of Organic Chemistry. 7: 1115-23. PMID 21915215 DOI: 10.3762/Bjoc.7.128  0.32
2011 Cumpstey I, Ramstadius C, Eszter Borbas K, Alonzi DS, Butters TD. Synthesis and α-Glucosidase II inhibitory activity of valienamine pseudodisaccharides relevant to N-glycan biosynthesis. Bioorganic & Medicinal Chemistry Letters. 21: 5219-23. PMID 21840710 DOI: 10.1016/J.Bmcl.2011.07.046  0.351
2011 Diot JD, Garcia Moreno I, Twigg G, Ortiz Mellet C, Haupt K, Butters TD, Kovensky J, Gouin SG. Amphiphilic 1-deoxynojirimycin derivatives through click strategies for chemical chaperoning in N370S Gaucher cells. The Journal of Organic Chemistry. 76: 7757-68. PMID 21830816 DOI: 10.1021/Jo201125X  0.402
2011 Kukushkin NV, Alonzi DS, Dwek RA, Butters TD. Demonstration that endoplasmic reticulum-associated degradation of glycoproteins can occur downstream of processing by endomannosidase. The Biochemical Journal. 438: 133-42. PMID 21585340 DOI: 10.1042/Bj20110186  0.303
2011 Ardes-Guisot N, Alonzi DS, Reinkensmeier G, Butters TD, Norez C, Becq F, Shimada Y, Nakagawa S, Kato A, Blériot Y, Sollogoub M, Vauzeilles B. Selection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain. Organic & Biomolecular Chemistry. 9: 5373-88. PMID 21512716 DOI: 10.1039/C1Ob05119A  0.349
2011 Alonzi DS, Butters TD. Therapeutic targets for inhibitors of glycosylation. Chimia. 65: 35-9. PMID 21469442 DOI: 10.2533/Chimia.2011.35  0.347
2011 Trapero A, Alfonso I, Butters TD, Llebaria A. Polyhydroxylated bicyclic isoureas and guanidines are potent glucocerebrosidase inhibitors and nanomolar enzyme activity enhancers in Gaucher cells. Journal of the American Chemical Society. 133: 5474-84. PMID 21413704 DOI: 10.1021/ja111480z  0.311
2011 Rasmussen TS, Allman S, Twigg G, Butters TD, Jensen HH. Synthesis of N-alkylated noeurostegines and evaluation of their potential as treatment for Gaucher's disease. Bioorganic & Medicinal Chemistry Letters. 21: 1519-22. PMID 21292481 DOI: 10.1016/J.Bmcl.2010.12.106  0.406
2011 Chang J, Schul W, Butters TD, Yip A, Liu B, Goh A, Lakshminarayana SB, Alonzi D, Reinkensmeier G, Pan X, Qu X, Weidner JM, Wang L, Yu W, Borune N, et al. Combination of α-glucosidase inhibitor and ribavirin for the treatment of dengue virus infection in vitro and in vivo. Antiviral Research. 89: 26-34. PMID 21073903 DOI: 10.1016/J.Antiviral.2010.11.002  0.354
2011 Rountree JSS, Butters TD, Dwek RA, Fleet GWJ. Enantiomeric 2-acetamido-1,4-dideoxy-1,4-iminoribitols as potential pyrrolidine hexosaminidase inhibitors Comptes Rendus Chimie. 14: 126-133. DOI: 10.1016/J.Crci.2010.03.020  0.381
2010 Jenkinson SF, Crabtree EV, Glawar AF, Butters TD, Fleet GW, Watkin DJ. 2-Acetamido-N-benzyl-1,4-imino-1,2,4-tride-oxy-l-xylitol (N-benzyl-l-XYLNAc). Acta Crystallographica. Section E, Structure Reports Online. 66: o1147-8. PMID 21579195 DOI: 10.1107/S1600536810014145  0.311
2010 Palma AS, Liu Y, Muhle-Goll C, Butters TD, Zhang Y, Childs R, Chai W, Feizi T. Multifaceted approaches including neoglycolipid oligosaccharide microarrays to ligand discovery for malectin. Methods in Enzymology. 478: 265-86. PMID 20816485 DOI: 10.1016/S0076-6879(10)78013-7  0.343
2010 Boomkamp SD, Rountree JS, Neville DC, Dwek RA, Fleet GW, Butters TD. Lysosomal storage of oligosaccharide and glycosphingolipid in imino sugar treated cells. Glycoconjugate Journal. 27: 297-308. PMID 20186478 DOI: 10.1007/S10719-010-9278-1  0.405
2010 Best D, Chairatana P, Glawar AFG, Crabtree E, Butters TD, Wilson FX, Yu CY, Wang WB, Jia YM, Adachi I, Kato A, Fleet GWJ. Synthesis of 2-acetamido-1,2-dideoxy-d-galacto-nojirimycin [DGJNAc] from d-glucuronolactone: the first sub-micromolar inhibitor of α-N-acetylgalactosaminidases Tetrahedron Letters. 51: 2222-2224. DOI: 10.1016/J.Tetlet.2010.02.063  0.347
2010 van den Broek L, Vermaas D, van Boeckel C, Rotteveel F, Zandberg P, van Kemenade F, Miedema F, Butters T, Tan M, Ploegh H. Synthesis of oxygen-substituted N-alkyl 1-deoxynojirimycin derivatives: Aza sugar α-glucosidase inhibitors showing antiviral (HIV-1) and immunosuppressive activity Recueil Des Travaux Chimiques Des Pays-Bas. 113: 507-516. DOI: 10.1002/Recl.19941131104  0.419
2009 Li H, Marcelo F, Bello C, Vogel P, Butters TD, Rauter AP, Zhang Y, Sollogoub M, Blériot Y. Design and synthesis of acetamido tri- and tetra-hydroxyazepanes: potent and selective beta-N-acetylhexosaminidase inhibitors. Bioorganic & Medicinal Chemistry. 17: 5598-604. PMID 19592259 DOI: 10.1016/J.Bmc.2009.06.022  0.351
2009 Wang GN, Reinkensmeier G, Zhang SW, Zhou J, Zhang LR, Zhang LH, Butters TD, Ye XS. Rational design and synthesis of highly potent pharmacological chaperones for treatment of N370S mutant Gaucher disease. Journal of Medicinal Chemistry. 52: 3146-9. PMID 19397268 DOI: 10.1021/Jm801506M  0.391
2009 Rawlings AJ, Lomas H, Pilling AW, Lee MJ, Alonzi DS, Rountree JS, Jenkinson SF, Fleet GW, Dwek RA, Jones JH, Butters TD. Synthesis and biological characterisation of novel N-alkyl-deoxynojirimycin alpha-glucosidase inhibitors. Chembiochem : a European Journal of Chemical Biology. 10: 1101-5. PMID 19294724 DOI: 10.1002/Cbic.200900025  0.411
2009 Butters TD, Alonzi DS, Kukushkin NV, Ren Y, Blériot Y. Novel mannosidase inhibitors probe glycoprotein degradation pathways in cells. Glycoconjugate Journal. 26: 1109-16. PMID 19234785 DOI: 10.1007/S10719-009-9231-3  0.366
2009 Yeoh KK, Butters TD, Wilkinson BL, Fairbanks AJ. Probing replacement of pyrophosphate via click chemistry; synthesis of UDP-sugar analogues as potential glycosyl transferase inhibitors. Carbohydrate Research. 344: 586-91. PMID 19233348 DOI: 10.1016/J.Carres.2009.01.001  0.331
2009 Rountree JS, Butters TD, Wormald MR, Boomkamp SD, Dwek RA, Asano N, Ikeda K, Evinson EL, Nash RJ, Fleet GW. Design, synthesis, and biological evaluation of enantiomeric beta-N-acetylhexosaminidase inhibitors LABNAc and DABNAc as potential agents against Tay-Sachs and Sandhoff disease. Chemmedchem. 4: 378-92. PMID 19145603 DOI: 10.1002/Cmdc.200800350  0.438
2009 Xu K, Antonopoulos A, Spanoudakis E, Parry S, Chaidos A, Hu M, Butters T, Dell A, Rahemtulla A, Horwood N, Karadimitris A. Glucose Ceramide Synthase Inhibitors Inhibit Osteoclast Activation Induced by Myeloma-Derived and De Novo Synthesized Glycosphingolipids. Blood. 114: 424-424. DOI: 10.1182/Blood.V114.22.424.424  0.352
2009 Alonzi DS, Dwek RA, Butters TD. Improved cellular inhibitors for glycoprotein processing α-glucosidases: biological characterisation of alkyl- and arylalkyl-N-substituted deoxynojirimycins Tetrahedron Asymmetry. 20: 897-901. DOI: 10.1016/J.Tetasy.2009.03.007  0.411
2008 Boomkamp SD, Butters TD. Glycosphingolipid disorders of the brain. Sub-Cellular Biochemistry. 49: 441-67. PMID 18751922 DOI: 10.1007/978-1-4020-8831-5_17  0.349
2008 Elliot-Smith E, Speak AO, Lloyd-Evans E, Smith DA, van der Spoel AC, Jeyakumar M, Butters TD, Dwek RA, d'Azzo A, Platt FM. Beneficial effects of substrate reduction therapy in a mouse model of GM1 gangliosidosis. Molecular Genetics and Metabolism. 94: 204-11. PMID 18387328 DOI: 10.1016/J.Ymgme.2008.02.005  0.352
2008 Li H, Liu T, Zhang Y, Favre S, Bello C, Vogel P, Butters TD, Oikonomakos NG, Marrot J, Blériot Y. New synthetic seven-membered 1-azasugars displaying potent inhibition towards glycosidases and glucosylceramide transferase. Chembiochem : a European Journal of Chemical Biology. 9: 253-60. PMID 18188862 DOI: 10.1002/Cbic.200700496  0.365
2008 Alonzi DS, Neville DC, Lachmann RH, Dwek RA, Butters TD. Glucosylated free oligosaccharides are biomarkers of endoplasmic- reticulum alpha-glucosidase inhibition. The Biochemical Journal. 409: 571-80. PMID 17868040 DOI: 10.1042/Bj20070748  0.383
2007 Walden CM, Sandhoff R, Chuang CC, Yildiz Y, Butters TD, Dwek RA, Platt FM, van der Spoel AC. Accumulation of glucosylceramide in murine testis, caused by inhibition of beta-glucosidase 2: implications for spermatogenesis. The Journal of Biological Chemistry. 282: 32655-64. PMID 17848577 DOI: 10.1074/Jbc.M702387200  0.33
2007 Brumshtein B, Greenblatt HM, Butters TD, Shaaltiel Y, Aviezer D, Silman I, Futerman AH, Sussman JL. Crystal structures of complexes of N-butyl- and N-nonyl-deoxynojirimycin bound to acid β-glucosidase: Insights into the mechanism of chemical chaperone action in Gaucher disease Journal of Biological Chemistry. 282: 29052-29058. PMID 17666401 DOI: 10.1074/Jbc.M705005200  0.384
2007 Lee JP, Jeyakumar M, Gonzalez R, Takahashi H, Lee PJ, Baek RC, Clark D, Rose H, Fu G, Clarke J, McKercher S, Meerloo J, Muller FJ, Park KI, Butters TD, et al. Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease. Nature Medicine. 13: 439-47. PMID 17351625 DOI: 10.1038/Nm1548  0.308
2007 Butters TD. Pharmacotherapeutic strategies using small molecules for the treatment of glycolipid lysosomal storage disorders. Expert Opinion On Pharmacotherapy. 8: 427-35. PMID 17309337 DOI: 10.1517/14656566.8.4.427  0.333
2007 Heare T, Alp NJ, Priestman DA, Kulkarni AB, Qasba P, Butters TD, Dwek RA, Clarke K, Channon KM, Platt FM. Severe endothelial dysfunction in the aorta of a mouse model of Fabry disease; partial prevention by N-butyldeoxynojirimycin treatment. Journal of Inherited Metabolic Disease. 30: 79-87. PMID 17189993 DOI: 10.1007/S10545-006-0473-Y  0.313
2007 Rountree JSS, Butters TD, Wormald MR, Dwek RA, Asano N, Ikeda K, Evinson EL, Nash RJ, Fleet GWJ. Efficient synthesis from d-lyxonolactone of 2-acetamido-1,4-imino-1,2,4-trideoxy-l-arabinitol LABNAc, a potent pyrrolidine inhibitor of hexosaminidases Tetrahedron Letters. 48: 4287-4291. DOI: 10.1016/J.Tetlet.2007.04.041  0.34
2006 Gadola SD, Silk JD, Jeans A, Illarionov PA, Salio M, Besra GS, Dwek R, Butters TD, Platt FM, Cerundolo V. Impaired selection of invariant natural killer T cells in diverse mouse models of glycosphingolipid lysosomal storage diseases. The Journal of Experimental Medicine. 203: 2293-303. PMID 16982810 DOI: 10.1084/Jem.20060921  0.308
2006 Norris-Cervetto E, Butters TD, Martin C, Modok S, Dwek RA, Callaghan R. Can P-glycoprotein influence the bioavailability of iminosugar-based glucosylceramide synthase inhibitors? European Journal of Pharmacology. 530: 195-204. PMID 16403499 DOI: 10.1016/J.Ejphar.2005.11.038  0.319
2006 Harding CC, Rountree JSS, Watkin DJ, Cowley AR, Butters TD, Wormald MR, Dwek RA, Fleet GWJ. 2-Acetamido-N-benzyl-1,4-imino-1,2,4-trideoxy-L-arabinitol 0.33-hydrate Acta Crystallographica Section E: Structure Reports Online. 61: o1683-o1685. DOI: 10.1107/S1600536805014455  0.312
2005 Zitzmann N, Block T, Methta A, Rudd P, Burton D, Wilson I, Platt F, Butters T, Dwek RA. Glycosylation: Disease targets and therapy Advances in Experimental Medicine and Biology. 564: 1-2. PMID 16400797 DOI: 10.1007/0-387-25515-X_1  0.302
2005 Butters TD, Dwek RA, Platt FM. Imino sugar inhibitors for treating the lysosomal glycosphingolipidoses Glycobiology. 15: 43R-52R. PMID 15901676 DOI: 10.1093/Glycob/Cwi076  0.42
2005 Harding CC, Watkin DJ, Shane Rountree JS, Butters TD, Wormald MR, Dwek RA, Fleet GWJ. 2-Acetamido-N-benzyl-1,4-imino-1,2,4-trideoxy-L-ribitol Acta Crystallographica Section E: Structure Reports Online. 61: o930-o932. DOI: 10.1107/S1600536805006926  0.312
2005 Boucheron C, Desvergnes V, Compain P, Martin OR, Lavi A, Mackeen M, Wormald M, Dwek R, Butters TD. Design and synthesis of iminosugar-based inhibitors of glucosylceramide synthase: The search for new therapeutic agents against Gaucher disease Tetrahedron Asymmetry. 16: 1747-1756. DOI: 10.1016/J.Tetasy.2005.03.015  0.395
2004 Jeyakumar M, Smith DA, Williams IM, Borja MC, Neville DC, Butters TD, Dwek RA, Platt FM. NSAIDs increase survival in the Sandhoff disease mouse: synergy with N-butyldeoxynojirimycin. Annals of Neurology. 56: 642-9. PMID 15505823 DOI: 10.1002/Ana.20242  0.33
2004 Hoja-Łukowicz D, Butters TD, Lityńska A. Characterization of the oligosaccharide component of microsomal beta-glucuronidase from rat liver. Biochimie. 86: 363-72. PMID 15358052 DOI: 10.1016/J.Biochi.2004.05.008  0.31
2004 Yu CY, Asano N, Ikeda K, Wang MX, Butters TD, Wormald MR, Dwek RA, Winters AL, Nash RJ, Fleet GW. Looking glass inhibitors: L-DMDP, a more potent and specific inhibitor of alpha-glucosidases than the enantiomeric natural product DMDP. Chemical Communications (Cambridge, England). 1936-7. PMID 15340609 DOI: 10.1039/B406035K  0.355
2004 Neville DCA, Coquard V, Priestman DA, Te Vruchte DJM, Sillence DJ, Dwek RA, Platt FM, Butters TD. Analysis of fluorescently labeled glycosphingolipid-derived oligosaccharides following ceramide glycanase digestion and anthranilic acid labeling Analytical Biochemistry. 331: 275-282. PMID 15265733 DOI: 10.1016/J.Ab.2004.03.051  0.303
2004 Norris-Cervetto E, Callaghan R, Platt FM, Dwek RA, Butters TD. Inhibition of glucosylceramide synthase does not reverse drug resistance in cancer cells Journal of Biological Chemistry. 279: 40412-40418. PMID 15263008 DOI: 10.1074/Jbc.M404466200  0.31
2004 Andersson U, Smith D, Jeyakumar M, Butters TD, Borja MC, Dwek RA, Platt FM. Improved outcome of N-butyldeoxygalactonojirimycin-mediated substrate reduction therapy in a mouse model of Sandhoff disease Neurobiology of Disease. 16: 506-515. PMID 15262262 DOI: 10.1016/J.Nbd.2004.04.012  0.397
2004 Mellor HR, Neville DCA, Harvey DJ, Platt FM, Dwek RA, Butters TD. Cellular effects of deoxynojirimycin analogues: Inhibition of N-linked oligosaccharide processing and generation of free glucosylated oligosaccharides Biochemical Journal. 381: 867-875. PMID 15128289 DOI: 10.1042/Bj20031824  0.44
2004 Mellor HR, Neville DCA, Harvey DJ, Platt FM, Dwek RA, Butters TD. Cellular effects of deoxynojirimycin analogues: Uptake, retention and inhibition of glycosphingolipid biosynthesis Biochemical Journal. 381: 861-866. PMID 15128268 DOI: 10.1042/Bj20031822  0.41
2004 Andersson U, Reinkensmeier G, Butters TD, Dwek RA, Platt FM. Inhibition of glycogen breakdown by imino sugars in vitro and in vivo Biochemical Pharmacology. 67: 697-705. PMID 14757169 DOI: 10.1016/J.Bcp.2003.09.036  0.385
2004 Butters TD, Dwek RA, Platt FM. New therapeutics for the treatment of glycosphingolipid lysosomal storage diseases. Advances in Experimental Medicine and Biology. 535: 219-26. PMID 14714898 DOI: 10.1007/978-1-4615-0065-0_14  0.389
2003 Cumpstey I, Butters TD, Tennant-Eyles RJ, Fairbanks AJ, France RR, Wormald MR. Synthesis of fluorescence-labelled disaccharide substrates of glucosidase II. Carbohydrate Research. 338: 1937-49. PMID 14499570 DOI: 10.1016/S0008-6215(03)00255-6  0.325
2003 Platt FM, Jeyakumar M, Andersson U, Heare T, Dwek RA, Butters TD. Substrate reduction therapy in mouse models of the glycosphingolipidoses. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 358: 947-54. PMID 12803928 DOI: 10.1098/Rstb.2003.1279  0.365
2003 Butters TD, Mellor HR, Narita K, Dwek RA, Platt FM. Small-molecule therapeutics for the treatment of glycolipid lysosomal storage disorders. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 358: 927-45. PMID 12803927 DOI: 10.1098/Rstb.2003.1278  0.38
2003 Mellor HR, Platt FM, Dwek RA, Butters TD. Membrane disruption and cytotoxicity of hydrophobic N-alkylated imino sugars is independent of the inhibition of protein and lipid glycosylation. The Biochemical Journal. 374: 307-14. PMID 12769816 DOI: 10.1042/Bj20030348  0.411
2003 Butters TD, Dwek RA, Platt FM. Therapeutic applications of imino sugars in lysosomal storage disorders. Current Topics in Medicinal Chemistry. 3: 561-74. PMID 12570866 DOI: 10.2174/1568026033452483  0.404
2003 Svensson M, Frendeus B, Butters T, Platt F, Dwek R, Svanborg C. Glycolipid depletion in antimicrobial therapy. Molecular Microbiology. 47: 453-61. PMID 12519195 DOI: 10.1046/J.1365-2958.2003.03306.X  0.306
2003 Jeyakumar M, Butters TD, Dwek RA, Platt FM. Glycosphingolipid lysosomal storage diseases: therapy and pathogenesis. Neuropathology and Applied Neurobiology. 28: 343-57. PMID 12366816 DOI: 10.1046/J.1365-2990.2002.00422.X  0.312
2002 Butters TD. Control in the N-linked glycoprotein biosynthesis pathway. Chemistry & Biology. 9: 1266-8. PMID 12498877 DOI: 10.1016/S1074-5521(02)00290-9  0.36
2002 Sillence DJ, Puri V, Marks DL, Butters TD, Dwek RA, Pagano RE, Platt FM. Glucosylceramide modulates membrane traffic along the endocytic pathway. Journal of Lipid Research. 43: 1837-45. PMID 12401882 DOI: 10.1194/Jlr.M200232-Jlr200  0.347
2002 Jeyakumar M, Smith D, Eliott-Smith E, Cortina-Borja M, Reinkensmeier G, Butters TD, Lemm T, Sandhoff K, Perry VH, Dwek RA, Platt FM. An inducible mouse model of late onset Tay-Sachs disease. Neurobiology of Disease. 10: 201-10. PMID 12270683 DOI: 10.1006/Nbdi.2002.0511  0.304
2002 Dwek RA, Butters TD, Platt FM, Zitzmann N. Targeting glycosylation as a therapeutic approach. Nature Reviews. Drug Discovery. 1: 65-75. PMID 12119611 DOI: 10.1038/Nrd708  0.342
2002 Mellor HR, Nolan J, Pickering L, Wormald MR, Platt FM, Dwek RA, Fleet GW, Butters TD. Preparation, biochemical characterization and biological properties of radiolabelled N-alkylated deoxynojirimycins. The Biochemical Journal. 366: 225-33. PMID 11982484 DOI: 10.1042/Bj20020466  0.357
2002 Ennis SC, Cumpstey I, Fairbanks AJ, Butters TD, Mackeen M, Wormald MR. Total synthesis of the Glc3Man N-glycan tetrasaccharide Tetrahedron. 58: 9403-9411. DOI: 10.1016/S0040-4020(02)01221-8  0.319
2001 Wing DR, Garner B, Hunnam V, Reinkensmeier G, Andersson U, Harvey DJ, Dwek RA, Platt FM, Butters TD. High-performance liquid chromatography analysis of ganglioside carbohydrates at the picomole level after ceramide glycanase digestion and fluorescent labeling with 2-aminobenzamide. Analytical Biochemistry. 298: 207-17. PMID 11700975 DOI: 10.1006/Abio.2001.5393  0.301
2001 Durantel D, Branza-Nichita N, Carrouée-Durantel S, Butters TD, Dwek RA, Zitzmann N. Study of the mechanism of antiviral action of iminosugar derivatives against bovine viral diarrhea virus. Journal of Virology. 75: 8987-98. PMID 11533162 DOI: 10.1128/Jvi.75.19.8987-8998.2001  0.353
2001 Platt FM, Jeyakumar M, Andersson U, Priestman DA, Dwek RA, Butters TD, Cox TM, Lachmann RH, Hollak C, Aerts JMFG, Van Weely S, Hrebícek M, Moyses C, Gow I, Elstein D, et al. Inhibition of substrate synthesis as a strategy for glycolipid lysosomal storage disease therapy Journal of Inherited Metabolic Disease. 24: 275-290. PMID 11405346 DOI: 10.1023/A:1010335505357  0.364
2001 Mehta A, Carrouée S, Conyers B, Jordan R, Butters T, Dwek RA, Block TM. Inhibition of hepatitis B virus DNA replication by imino sugars without the inhibition of the DNA polymerase: therapeutic implications. Hepatology (Baltimore, Md.). 33: 1488-95. PMID 11391538 DOI: 10.1053/Jhep.2001.25103  0.384
2001 Svensson M, Platt F, Frendeus B, Butters T, Dwek R, Svanborg C. Carbohydrate receptor depletion as an antimicrobial strategy for prevention of urinary tract infection. The Journal of Infectious Diseases. S70-3. PMID 11171019 DOI: 10.1086/318852  0.374
2001 Jeyakumar M, Norflus F, Tifft CJ, Cortina-Borja M, Butters TD, Proia RL, Perry VH, Dwek RA, Platt FM. Enhanced survival in Sandhoff disease mice receiving a combination of substrate deprivation therapy and bone marrow transplantation. Blood. 97: 327-9. PMID 11133779 DOI: 10.1182/Blood.V97.1.327  0.325
2000 Platt FM, Butters TD. Substrate deprivation: a new therapeutic approach for the glycosphingolipid lysosomal storage diseases. Expert Reviews in Molecular Medicine. 2: 1-17. PMID 14585134 DOI: 10.1017/S1462399400001484  0.344
2000 Mellor HR, Adam A, Platt FM, Dwek RA, Butters TD. High-performance cation-exchange chromatography and pulsed amperometric detection for the separation, detection, and quantitation of N-alkylated imino sugars in biological samples. Analytical Biochemistry. 284: 136-42. PMID 10933866 DOI: 10.1006/Abio.2000.4678  0.336
2000 Cox T, Lachmann R, Hollak C, Aerts J, Van Weely S, Hrebícek M, Platt F, Butters T, Dwek R, Moyses C, Gow I, Elstein D, Zimran A. Novel oral treatment of Gaucher's disease with N-butyldeoxynojirimycin (OGT 918) to decrease substrate biosynthesis Lancet. 355: 1481-1485. PMID 10801168 DOI: 10.1016/S0140-6736(00)02161-9  0.329
2000 Andersson U, Butters TD, Dwek RA, Platt FM. N-butyldeoxygalactonojirimycin: a more selective inhibitor of glycosphingolipid biosynthesis than N-butyldeoxynojirimycin, in vitro and in vivo. Biochemical Pharmacology. 59: 821-9. PMID 10718340 DOI: 10.1016/S0006-2952(99)00384-6  0.406
2000 Butters T, van den Broek L, Fleet G, Krulle T, Wormald M, Dwek R, Platt F. Molecular requirements of imino sugars for the selective control of N-linked glycosylation and glycosphingolipid biosynthesis Tetrahedron: Asymmetry. 11: 113-124. DOI: 10.1016/S0957-4166(99)00468-1  0.435
1999 Zitzmann N, Mehta AS, Carrouée S, Butters TD, Platt FM, McCauley J, Blumberg BS, Dwek RA, Block TM. Imino sugars inhibit the formation and secretion of bovine viral diarrhea virus, a pestivirus model of hepatitis C virus: implications for the development of broad spectrum anti-hepatitis virus agents. Proceedings of the National Academy of Sciences of the United States of America. 96: 11878-82. PMID 10518544 DOI: 10.1073/Pnas.96.21.11878  0.322
1999 Butters TD, Sparks LM, Harlos K, Ikemizu S, Stuart DI, Jones EY, Davis SJ. Effects of N-butyldeoxynojirimycin and the Lec3.2.8.1 mutant phenotype on N-glycan processing in Chinese hamster ovary cells: Application to glycoprotein crystallization Protein Science. 8: 1696-1701. PMID 10452614 DOI: 10.1110/Ps.8.8.1696  0.347
1999 Jeyakumar M, Butters TD, Cortina-Borja M, Hunnam V, Proia RL, Perry VH, Dwek RA, Platt FM. Delayed symptom onset and increased life expectancy in Sandhoff disease mice treated with N-butyldeoxynojirimycin. Proceedings of the National Academy of Sciences of the United States of America. 96: 6388-93. PMID 10339597 DOI: 10.1073/Pnas.96.11.6388  0.365
1999 Shilvock JP, Nash RJ, Watson AA, Winters AL, Butters TD, Dwek RA, Winkler DA, Fleet GWJ. Piperidine analogues of D-galactose as potent inhibitors of α-galactosidase: Synthesis by stannane-mediated hydroxymethylation of 5-azido-1,4-lactones. Structural relationships between D-galactosidase and L-rhamnosidase inhibitors Journal of the Chemical Society-Perkin Transactions 1. 2747-2754. DOI: 10.1039/A904145A  0.351
1999 Shilvock JP, Wheatley JR, Nash RJ, Watson AA, Griffiths RC, Butters TD, Müller M, Watkin DJ, Winkler DA, Fleet GWJ. Synthesis of homorhamnojirimycins and related trihydroxypipecolic acid derivatives via divergent bicyclic amino lactone intermediates: Inhibition of naringinase (L-rhamnosidase) and dTDP-rhamnose biosynthesis Journal of the Chemical Society-Perkin Transactions 1. 2735-2745. DOI: 10.1039/A904064A  0.304
1999 Martı́n A, Butters TD, Fleet GW. Synthesis and biological evaluation of enantiomeric rhamnose analogues of the antitumour agent spicamycin—is the mode of action by modification of N-linked glycoproteins? Tetrahedron: Asymmetry. 10: 2343-2360. DOI: 10.1016/S0957-4166(99)00240-2  0.33
1999 Scott DA, Krülle TM, Finn M, Nash RJ, Winters AL, Asano N, Butters TD, Fleet GWJ. Synthesis of bis(1,3-dihydroxy-isopropyl)amine by reductive amination of dihydroxyacetone: Open chain equivalent of DMDP and a potential AB4 dendritic monomer Tetrahedron Letters. 40: 7581-7584. DOI: 10.1016/S0040-4039(99)01611-1  0.36
1998 Platt FM, Butters TD. New therapeutic prospects for the glycosphingolipid lysosomal storage diseases. Biochemical Pharmacology. 56: 421-430. PMID 9763217 DOI: 10.1016/S0006-2952(98)00115-4  0.346
1998 Butters TD, Yudkin B, Jacob GS, Jones IM. Structural characterization of the N-linked oligosaccharides derived from HIVgp120 expressed in lepidopteran cells. Glycoconjugate Journal. 15: 83-88. PMID 9530961 DOI: 10.1023/A:1006999718552  0.339
1997 Petrescu AJ, Butters TD, Reinkensmeier G, Petrescu S, Platt FM, Dwek RA, Wormald MR. The solution NMR structure of glucosylated N-glycans involved in the early stages of glycoprotein biosynthesis and folding. The Embo Journal. 16: 4302-10. PMID 9250674 DOI: 10.1093/Emboj/16.14.4302  0.363
1997 Platt FM, Reinkensmeier G, Dwek RA, Butters TD. Extensive glycosphingolipid depletion in the liver and lymphoid organs of mice treated with N-butyldeoxynojirimycin. The Journal of Biological Chemistry. 272: 19365-72. PMID 9235935 DOI: 10.1074/Jbc.272.31.19365  0.369
1997 Platt FM, Neises GR, Reinkensmeier G, Townsend MJ, Perry VH, Proia RL, Winchester B, Dwek RA, Butters TD. Prevention of lysosomal storage in Tay-Sachs mice treated with N-butyldeoxynojirimycin. Science (New York, N.Y.). 276: 428-31. PMID 9103204 DOI: 10.1126/Science.276.5311.428  0.39
1997 Neises GR, Woodman PG, Butters TD, Ornberg RL, Platt FM. Ultrastructural changes in the Golgi apparatus and secretory granules of HL-60 cells treated with the imino sugar N-butyldeoxynojirimycin. Biology of the Cell. 89: 123-131. DOI: 10.1016/S0248-4900(99)80071-9  0.375
1996 Broek LAGMVD, Nieuwenhof MWPKD, Butters TD, Boeckel CAAV. Synthesis of α-Glucosidase I Inhibitors Showing Antiviral (HIV-1) and Immunosuppressive Activity Journal of Pharmacy and Pharmacology. 48: 172-178. PMID 8935166 DOI: 10.1111/J.2042-7158.1996.Tb07117.X  0.398
1996 Lu X, Mehta A, Dwek R, Butters T, Block T. Evidence that N-linked glycosylation is necessary for hepatitis B virus secretion. Virology. 213: 660-5. PMID 7491790 DOI: 10.1006/Viro.1995.0038  0.371
1995 Clarke VA, Platt N, Butters TD. Cloning and expression of the beta-N-acetylglucosaminidase gene from Streptococcus pneumoniae. Generation of truncated enzymes with modified aglycon specificity Journal of Biological Chemistry. 270: 8805-8814. PMID 7721787 DOI: 10.1074/Jbc.270.15.8805  0.336
1995 Platt FM, Butters TD, 稔久 太. Inhibitors of Glycosphingolipid Biosynthesis Trends in Glycoscience and Glycotechnology. 7: 495-511. DOI: 10.4052/Tigg.7.495  0.399
1993 Ardron H, Butters TD, Platt FM, Wormald MR, Dwek RA, Fleet GW, Jacob GS. Synthesis of 1,5-dideoxy-3-O-(α-D-mannopyranosyl)-1,5-imino-D-mannitol and 1,5-dideoxy-3-O-(α-D-glucopyranosyl)-1,5-imino-D-mannitol: Powerful inhibitors of endomannosidase Tetrahedron: Asymmetry. 4: 2011-2024. DOI: 10.1016/S0957-4166(00)82250-8  0.303
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