Stuart J. Conway, PhD - Related publications

Affiliations: 
2003-2005 School fo Chemistry University of St Andrews, Saint Andrews, Scotland, United Kingdom 
 2008- Department of Chemistry University of Oxford, Oxford, United Kingdom 
Area:
Chemical biology, organic chemistry
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Kjaer VMS, Ieremias L, Daugvilaite V, Lückmann M, Frimurer TM, Ulven T, Rosenkilde MM, Våbenø J. Discovery of GPR183 Agonists Based on an Antagonist Scaffold. Chemmedchem. PMID 34270165 DOI: 10.1002/cmdc.202100301   
2021 Giubilaro J, Schuetz DA, Stepniewski TM, Namkung Y, Khoury E, Lara-Márquez M, Campbell S, Beautrait A, Armando S, Radresa O, Duchaine J, Lamarche-Vane N, Claing A, Selent J, Bouvier M, et al. Discovery of a dual Ras and ARF6 inhibitor from a GPCR endocytosis screen. Nature Communications. 12: 4688. PMID 34344896 DOI: 10.1038/s41467-021-24968-y   
2021 van Aalst E, Wylie BJ. Cholesterol Is a Dose-Dependent Positive Allosteric Modulator of CCR3 Ligand Affinity and G Protein Coupling. Frontiers in Molecular Biosciences. 8: 724603. PMID 34490352 DOI: 10.3389/fmolb.2021.724603   
2021 Dutt Konar A, Jain AK, Gupta A, Karthikeyan C, Trivedi P. Unravelling the selectivity of 6,7 dimethyl Quinoxaline analogues for kinase inhibition: An Insight towards the development of Alzheimer's therapeutics. Chemistry & Biodiversity. PMID 34486216 DOI: 10.1002/cbdv.202100364   
2021 Ren X, Gelinas AD, Linehan M, Iwasaki A, Wang W, Janjic N, Marie Pyle A. Title: Evolving a RIG-I antagonist: a modified DNA aptamer mimics viral RNA. Journal of Molecular Biology. 167227. PMID 34487794 DOI: 10.1016/j.jmb.2021.167227   
2021 Patel A, Bhatt M, Soni A, Sharma P. Identification of steroidal saponins from Tribulus terrestris and their in silico docking studies. Journal of Cellular Biochemistry. PMID 34337761 DOI: 10.1002/jcb.30113   
2021 Yuan Y, Jia G, Wu C, Wang W, Cheng L, Li Q, Li Z, Luo K, Yang S, Yan W, Su Z, Shao Z. Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation and drug recognition. Cell Research. PMID 34526663 DOI: 10.1038/s41422-021-00566-x   
2021 Lee Y, Hou X, Lee JH, Nayak A, Alexander V, Sharma PK, Chang H, Phan K, Gao ZG, Jacobson KA, Choi S, Jeong LS. Subtle Chemical Changes Cross the Boundary between Agonist and Antagonist: New A Adenosine Receptor Homology Models and Structural Network Analysis Can Predict This Boundary. Journal of Medicinal Chemistry. PMID 34435786 DOI: 10.1021/acs.jmedchem.1c00239   
2021 Ben David A, Barnea A, Diamant E, Dor E, Schwartz A, Torgeman A, Zichel R. Small Molecule Receptor Binding Inhibitors with In Vivo Efficacy against Botulinum Neurotoxin Serotypes A and E. International Journal of Molecular Sciences. 22. PMID 34445283 DOI: 10.3390/ijms22168577   
2021 Smith C, Li A, Krishnamurthy N, Lemmon MA. Phosphatidylserine binding directly regulates TIM-3 function. The Biochemical Journal. PMID 34435619 DOI: 10.1042/BCJ20210425   
2021 Wu N, Olechwier AM, Brunner C, Edwards PC, Tsai CJ, Tate CG, Schertler GFX, Schneider G, Deupi X, Zenobi R, Ma P. High-mass MALDI-MS unravels ligand-mediated G protein-coupling selectivity to GPCRs. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34326250 DOI: 10.1073/pnas.2024146118   
2021 Nobrega JN, Raymond R, Rajji TK, Pollock BG. A calcium fluorescence assay for quantification of cholinergic receptor activity of clinical drugs in serum - comparison with radioactive methods. Journal of Pharmacological and Toxicological Methods. 107118. PMID 34481920 DOI: 10.1016/j.vascn.2021.107118   
2021 Sahoo CR, Paidesetty SK, Sarathbabu S, Dehury B, Senthil Kumar N, Padhy RN. Molecular dynamics simulation, synthesis and topoisomerase inhibitory actions of vanillin derivatives: a systematic computational structural integument. Journal of Biomolecular Structure & Dynamics. 1-11. PMID 34355674 DOI: 10.1080/07391102.2021.1961867   
2021 Manoliu LCE, Martin EC, Milac AL, Spiridon L. Effective Use of Empirical Data for Virtual Screening against APJR GPCR Receptor. Molecules (Basel, Switzerland). 26. PMID 34443478 DOI: 10.3390/molecules26164894   
2021 Meng Q, Fu Y, Li S, Yan Y, Duan D, Anthony DD, Zhu Y, Wu X, Qian F, Wu C. Rapid, sensitive and cost-effective determination of immune checkpoint inhibitor activity using a magnetic bead-based binding assay. Journal of Immunological Methods. 113134. PMID 34464606 DOI: 10.1016/j.jim.2021.113134   
2021 Shih TL, Lin KH, Chen RJ, Chen TY, Kao WT, Liu JW, Wang HH, Peng HY, Sun YY, Lu WJ. A novel naphthalimide derivative reduces platelet activation and thrombus formation via suppressing GPVI. Journal of Cellular and Molecular Medicine. PMID 34448532 DOI: 10.1111/jcmm.16886   
2021 Deganutti G, Atanasio S, Rujan RM, Sexton PM, Wootten D, Reynolds CA. Exploring Ligand Binding to Calcitonin Gene-Related Peptide Receptors. Frontiers in Molecular Biosciences. 8: 720561. PMID 34513925 DOI: 10.3389/fmolb.2021.720561   
2021 Boily M, Li L, Vallerand D, Girouard H. Angiotensin II Disrupts Neurovascular Coupling by Potentiating Calcium Increases in Astrocytic Endfeet. Journal of the American Heart Association. e020608. PMID 34459216 DOI: 10.1161/JAHA.120.020608   
2021 Haider S, Pandey P, Reddy CR, Lambert JA, Chittiboyina AG. Novel Machaeriol Analogues as Modulators of Cannabinoid Receptors: Structure-Activity Relationships of (+)-Hexahydrocannabinoids and Their Isoform Selectivities. Acs Omega. 6: 20408-20421. PMID 34395989 DOI: 10.1021/acsomega.1c02413   
2021 Singh KD, Jara ZP, Harford T, Saha PP, Pardhi TR, Desnoyer R, Karnik SS. Novel allosteric ligands of the angiotensin receptor AT1R as autoantibody blockers. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34380734 DOI: 10.1073/pnas.2019126118   
2021 Hus-Citharel A, Bouby N, Corbani M, Mion J, Mendre C, Darusi J, Tomboly C, Trueba M, Serradeil-Le Gal C, Llorens-Cortes C, Guillon G. Characterization of a functional V vasopressin receptor in the male rat kidney, evidence for crosstalk between V and V receptor signaling pathways. American Journal of Physiology. Renal Physiology. PMID 34282956 DOI: 10.1152/ajprenal.00081.2021   
2021 Huang SJ, Zuo MT, Qi XJ, Huang CY, Liu ZY. Phosphoproteomics reveals NMDA receptor-mediated excitotoxicity as a key signaling pathway in the toxicity of gelsenicine. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 112507. PMID 34389372 DOI: 10.1016/j.fct.2021.112507   
2021 Mustafá ER, Cordisco González S, Damian M, Cantel S, Denoyelle S, Wagner R, Schiöth HB, Fehrentz JA, Banères JL, Perelló M, Raingo J. LEAP2 Impairs the Capability of the Growth Hormone Secretagogue Receptor to Regulate the Dopamine 2 Receptor Signaling. Frontiers in Pharmacology. 12: 712437. PMID 34447311 DOI: 10.3389/fphar.2021.712437   
2021 Basit A, Karim AM, Asif M, Ali T, Lee JH, Jeon JH, Rehman SU, Lee SH. Designing Short Peptides to Block the Interaction of SARS-CoV-2 and Human ACE2 for COVID-19 Therapeutics. Frontiers in Pharmacology. 12: 731828. PMID 34512357 DOI: 10.3389/fphar.2021.731828   
2021 Cui Y, Chu F, Yin K, Chen X, Wan H, Luo G, Dong H, Xu F. Role of Serosal TRPV4-Constituted SOCE Mechanism in Secretagogues-Stimulated Intestinal Epithelial Anion Secretion. Frontiers in Pharmacology. 12: 684538. PMID 34335254 DOI: 10.3389/fphar.2021.684538   
2021 Dodat F, Mader S, Lévesque D. Minireview: what is known about SUMOylation among NR4A family members? Journal of Molecular Biology. 167212. PMID 34437889 DOI: 10.1016/j.jmb.2021.167212   
2021 Zhao X, Fu X, Yuan X, Shayiranbieke A, Xu R, Cao F, Ren J, Liang Q, Zhao X. Development and characterization of a selective chromatographic approach to the rapid discovery of ligands binding to muscarinic-3 acetylcholine receptor. Journal of Chromatography. A. 1653: 462443. PMID 34365202 DOI: 10.1016/j.chroma.2021.462443   
2021 Hu J, Gao M, Zhang Y, Wang Y, Qiao Z, Zhang W, Wang Q, Yan L, Qian H. Novel piperazine urea derivatives as highly potent transient receptor potential vanilloid 1 (TRPV1) antagonists. Bioorganic Chemistry. 115: 105229. PMID 34364049 DOI: 10.1016/j.bioorg.2021.105229   
2021 Myers SJ, Ruppa KP, Wilson LJ, Tahirovic YA, Lyuboslavsky P, Menaldino DS, Dentmon ZW, Koszalka GW, Zaczek R, Dingledine RJ, Traynelis SF, Liotta DC. . The Journal of Pharmacology and Experimental Therapeutics. PMID 34493631 DOI: 10.1124/jpet.120.000370   
2021 Zhang H, Chen LN, Yang D, Mao C, Shen Q, Feng W, Shen DD, Dai A, Xie S, Zhou Y, Qin J, Sun JP, Scharf DH, Hou T, Zhou T, et al. Structural insights into ligand recognition and activation of the melanocortin-4 receptor. Cell Research. PMID 34433901 DOI: 10.1038/s41422-021-00552-3   
2021 Hayashi T, Katoh L, Ozoe F, Ozoe Y. Structure-dependent receptor subtype selectivity and G protein subtype preference of heterocyclic agonists in heterologously expressed silkworm octopamine receptors. Pesticide Biochemistry and Physiology. 177: 104895. PMID 34301357 DOI: 10.1016/j.pestbp.2021.104895   
2021 Ochiai K, Fujii S. Structure-property and structure-activity relationships of phenylferrocene derivatives as androgen receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 46: 128141. PMID 34048883 DOI: 10.1016/j.bmcl.2021.128141   
2021 Dai J, Teng X, Jin S, Wu Y. The Antiviral Roles of Hydrogen Sulfide by Blocking the Interaction between SARS-CoV-2 and Its Potential Cell Surface Receptors. Oxidative Medicine and Cellular Longevity. 2021: 7866992. PMID 34497683 DOI: 10.1155/2021/7866992   
2021 Berthier A, Staels B, Lefebvre P. An optimized protocol with a stepwise approach to identify specific nuclear receptor ligands from cultured mammalian cells. Star Protocols. 2: 100658. PMID 34286290 DOI: 10.1016/j.xpro.2021.100658   
2021 Cao AM, Quast RB, Fatemi F, Rondard P, Pin JP, Margeat E. Allosteric modulators enhance agonist efficacy by increasing the residence time of a GPCR in the active state. Nature Communications. 12: 5426. PMID 34521824 DOI: 10.1038/s41467-021-25620-5   
2021 Wang X, Sandberg ML, Martin AD, Negri KR, Gabrelow GB, Nampe DP, Wu ML, McElvain ME, Toledo Warshaviak D, Lee WH, Oh J, Daris ME, Chai F, Yao C, Furney J, et al. Potent, Selective CARs as Potential T-Cell Therapeutics for HPV-positive Cancers. Journal of Immunotherapy (Hagerstown, Md. : 1997). PMID 34432728 DOI: 10.1097/CJI.0000000000000386   
2021 Gonias SL. Plasminogen activator receptor assemblies in cell-signaling, innate immunity, and inflammation. American Journal of Physiology. Cell Physiology. PMID 34406905 DOI: 10.1152/ajpcell.00269.2021   
2021 Ma S, Chen Y, Dai A, Yin W, Guo J, Yang D, Zhou F, Jiang Y, Wang MW, Xu HE. Structural mechanism of calcium-mediated hormone recognition and Gβ interaction by the human melanocortin-1 receptor. Cell Research. PMID 34453129 DOI: 10.1038/s41422-021-00557-y   
2021 Proudman RGW, Baker JG. The selectivity of α-adrenoceptor agonists for the human α1A, α1B, and α1D-adrenoceptors. Pharmacology Research & Perspectives. 9: e00799. PMID 34355529 DOI: 10.1002/prp2.799   
2021 Harvey RD, Clancy CE. Mechanisms of cAMP compartmentation in cardiac myocytes: Experimental and computational approaches to understanding. The Journal of Physiology. PMID 34510451 DOI: 10.1113/JP280801   
2021 Facchini FA, Minotti A, Luraghi A, Romerio A, Gotri N, Matamoros-Recio A, Iannucci A, Palmer C, Wang G, Ingram R, Martin-Santamaria S, Pirianov G, De Andrea M, Valvano MA, Peri F. Synthetic Glycolipids as Molecular Vaccine Adjuvants: Mechanism of Action in Human Cells and In Vivo Activity. Journal of Medicinal Chemistry. 64: 12261-12272. PMID 34382796 DOI: 10.1021/acs.jmedchem.1c00896   
2021 González-Santana A, Estévez-Herrera J, Seward EP, Borges R, Machado JD. Glucagon-like peptide-1 receptor controls exocytosis in chromaffin cells by increasing full-fusion events. Cell Reports. 36: 109609. PMID 34433018 DOI: 10.1016/j.celrep.2021.109609   
2021 Lefranc B, Alim K, Neveu C, Le Marec O, Dubessy C, Boutin JA, Chuquet J, Vaudry D, Prévost G, Picot M, Vaudry H, Chartrel N, Leprince J. Point-Substitution of Phenylalanine Residues of 26RFa Neuropeptide: A Structure-Activity Relationship Study. Molecules (Basel, Switzerland). 26. PMID 34299587 DOI: 10.3390/molecules26144312   
2021 Sun J, Liu HY, Zhang YH, Fang ZY, Lv PC. Design, synthesis and bioactivity evaluation of thiazolidinedione derivatives as partial agonists targeting PPARγ. Bioorganic Chemistry. 116: 105342. PMID 34536928 DOI: 10.1016/j.bioorg.2021.105342   
2021 Kirstgen M, Müller SF, Lowjaga KAAT, Goldmann N, Lehmann F, Alakurtti S, Yli-Kauhaluoma J, Baringhaus KH, Krieg R, Glebe D, Geyer J. Identification of Novel HBV/HDV Entry Inhibitors by Pharmacophore- and QSAR-Guided Virtual Screening. Viruses. 13. PMID 34452354 DOI: 10.3390/v13081489   
2021 Lu S, He X, Yang Z, Chai Z, Zhou S, Wang J, Rehman AU, Ni D, Pu J, Sun J, Zhang J. Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design. Nature Communications. 12: 4721. PMID 34354057 DOI: 10.1038/s41467-021-25020-9   
2021 Chen Z, Oh D, Biswas KH, Zaidel-Bar R, Groves JT. Probing the effect of clustering on EphA2 receptor signaling efficiency by subcellular control of ligand-receptor mobility. Elife. 10. PMID 34414885 DOI: 10.7554/eLife.67379   
2021 Pankiewicz P, Szybiński M, Kisielewska K, Gołębiowski F, Krzemiński P, Rutkowska-Włodarczyk I, Moszczyński-Pętkowski R, Gurba-Bryśkiewicz L, Delis M, Mulewski K, Smuga D, Dominowski J, Janusz A, Górka M, Abramski K, et al. Do Small Molecules Activate the TrkB Receptor in the Same Manner as BDNF? Limitations of Published TrkB Low Molecular Agonists and Screening for Novel TrkB Orthosteric Agonists. Pharmaceuticals (Basel, Switzerland). 14. PMID 34451801 DOI: 10.3390/ph14080704   
2021 Vitale RM, Iannotti FA, Schiano Moriello A, Tunisi L, Piscitelli F, Savopoulos R, Cristino L, De Petrocellis L, Amodeo P, Gray R, Di Marzo V. Identification and Characterization of Cannabidiol as an OX1R Antagonist by Computational and In Vitro Functional Validation. Biomolecules. 11. PMID 34439801 DOI: 10.3390/biom11081134   
2021 González CM, Gaikwad S, Lasanta G, Loureiro J, Nilsson N, Peluso-Iltis C, Rochel N, Mouriño A. Design, synthesis and evaluation of side-chain hydroxylated derivatives of lithocholic acid as potent agonists of the vitamin D receptor (VDR). Bioorganic Chemistry. 115: 105202. PMID 34339974 DOI: 10.1016/j.bioorg.2021.105202