David E. Jane, PhD - Publications

Affiliations: 
Pharmacology University of Bristol, Bristol, England, United Kingdom 
Area:
Glutamate pharmacology and medicinal chemistry

123 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Irvine MW, Fang G, Sapkota K, Burnell ES, Volianskis A, Costa BM, Culley G, Collingridge GL, Monaghan DT, Jane DE. Investigation of the structural requirements for N-methyl-D-aspartate receptor positive and negative allosteric modulators based on 2-naphthoic acid. European Journal of Medicinal Chemistry. 164: 471-498. PMID 30622023 DOI: 10.1016/j.ejmech.2018.12.054  0.48
2018 Ingram R, Kang H, Lightman S, Jane DE, Bortolotto ZA, Collingridge GL, Lodge D, Volianskis A. Some distorted thoughts about ketamine as a psychedelic and a novel hypothesis based on NMDA receptor-mediated synaptic plasticity. Neuropharmacology. PMID 29885421 DOI: 10.1016/j.neuropharm.2018.06.008  0.48
2017 Sapkota K, Irvine MW, Fang G, Burnell ES, Bannister N, Volianskis A, Culley GR, Dravid SM, Collingridge GL, Jane DE, Monaghan DT. Mechanism and properties of positive allosteric modulation of N-methyl-d-aspartate receptors by 6-alkyl 2-naphthoic acid derivatives. Neuropharmacology. PMID 28709671 DOI: 10.1016/j.neuropharm.2017.07.007  0.48
2016 France G, Fernández-Fernández D, Burnell ES, Irvine MW, Monaghan DT, Jane DE, Bortolotto ZA, Collingridge GL, Volianskis A. Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus. Neuropharmacology. PMID 27523302 DOI: 10.1016/j.neuropharm.2016.08.010  0.48
2015 Irvine MW, Fang G, Eaves R, Mayo-Martin MB, Burnell ES, Costa BM, Culley GR, Volianskis A, Collingridge GL, Monaghan DT, Jane DE. Synthesis of a Series of Novel 3,9-Disubstituted Phenanthrenes as Analogues of Known NMDA Receptor Allosteric Modulators. Synthesis. 47: 1593-1610. PMID 26568642 DOI: 10.1055/s-0034-1380114  0.48
2015 Wallis JL, Irvine MW, Jane DE, Lodge D, Collingridge GL, Bortolotto ZA. An interchangeable role for kainate and metabotropic glutamate receptors in the induction of rat hippocampal mossy fiber long-term potentiation in vivo. Hippocampus. PMID 25821051 DOI: 10.1002/hipo.22460  1
2015 Volianskis A, France G, Jensen MS, Bortolotto ZA, Jane DE, Collingridge GL. Long-term potentiation and the role of N-methyl-d-aspartate receptors. Brain Research. PMID 25619552 DOI: 10.1016/j.brainres.2015.01.016  1
2015 Shoemark DK, Williams C, Fahey MS, Watson JJ, Tyler SJ, Scoltock SJ, Ellis RZ, Wickenden E, Burton AJ, Hemmings JL, Bailey CD, Dawbarn D, Jane DE, Willis CL, Sessions RB, et al. Design and nuclear magnetic resonance (NMR) structure determination of the second extracellular immunoglobulin tyrosine kinase A (TrkAIg2) domain construct for binding site elucidation in drug discovery. Journal of Medicinal Chemistry. 58: 767-77. PMID 25454499 DOI: 10.1021/jm501307e  1
2015 Irvine MW, Fang G, Eaves R, Mayo-Martin MB, Burnell ES, Costa BM, Culley GR, Volianskis A, Collingridge GL, Monaghan DT, Jane DE. Synthesis of a series of novel 3,9-disubstituted phenanthrenes as analogues of known N-methyl-D-aspartate receptor allosteric modulators Synthesis (Germany). 47: 1593-1610. DOI: 10.1055/s-0034-1380114  1
2014 Park P, Volianskis A, Sanderson TM, Bortolotto ZA, Jane DE, Zhuo M, Kaang BK, Collingridge GL. NMDA receptor-dependent long-term potentiation comprises a family of temporally overlapping forms of synaptic plasticity that are induced by different patterns of stimulation. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 369: 20130131. PMID 24298134 DOI: 10.1098/rstb.2013.0131  1
2013 Lodge D, Tidball P, Mercier MS, Lucas SJ, Hanna L, Ceolin L, Kritikos M, Fitzjohn SM, Sherwood JL, Bannister N, Volianskis A, Jane DE, Bortolotto ZA, Collingridge GL. Antagonists reversibly reverse chemical LTD induced by group I, group II and group III metabotropic glutamate receptors. Neuropharmacology. 74: 135-46. PMID 23542080 DOI: 10.1016/j.neuropharm.2013.03.011  1
2013 Volianskis A, Bannister N, Collett VJ, Irvine MW, Monaghan DT, Fitzjohn SM, Jensen MS, Jane DE, Collingridge GL. Different NMDA receptor subtypes mediate induction of long-term potentiation and two forms of short-term potentiation at CA1 synapses in rat hippocampus in vitro. The Journal of Physiology. 591: 955-72. PMID 23230236 DOI: 10.1113/jphysiol.2012.247296  1
2013 Mercier MS, Lodge D, Fang G, Nicolas CS, Collett VJ, Jane DE, Collingridge GL, Bortolotto ZA. Characterisation of an mGlu8 receptor-selective agonist and antagonist in the lateral and medial perforant path inputs to the dentate gyrus. Neuropharmacology. 67: 294-303. PMID 23220400 DOI: 10.1016/j.neuropharm.2012.11.020  1
2013 Collingridge GL, Volianskis A, Bannister N, France G, Hanna L, Mercier M, Tidball P, Fang G, Irvine MW, Costa BM, Monaghan DT, Bortolotto ZA, Molnár E, Lodge D, Jane DE. The NMDA receptor as a target for cognitive enhancement. Neuropharmacology. 64: 13-26. PMID 22796429 DOI: 10.1016/j.neuropharm.2012.06.051  1
2012 Sherwood JL, Amici M, Dargan SL, Culley GR, Fitzjohn SM, Jane DE, Collingridge GL, Lodge D, Bortolotto ZA. Differences in kainate receptor involvement in hippocampal mossy fibre long-term potentiation depending on slice orientation. Neurochemistry International. 61: 482-9. PMID 22564530 DOI: 10.1016/j.neuint.2012.04.021  1
2012 Monaghan DT, Irvine MW, Costa BM, Fang G, Jane DE. Pharmacological modulation of NMDA receptor activity and the advent of negative and positive allosteric modulators. Neurochemistry International. 61: 581-92. PMID 22269804 DOI: 10.1016/j.neuint.2012.01.004  1
2012 Irvine MW, Costa BM, Volianskis A, Fang G, Ceolin L, Collingridge GL, Monaghan DT, Jane DE. Coumarin-3-carboxylic acid derivatives as potentiators and inhibitors of recombinant and native N-methyl-D-aspartate receptors. Neurochemistry International. 61: 593-600. PMID 22265875 DOI: 10.1016/j.neuint.2011.12.020  1
2012 Costa BM, Irvine MW, Fang G, Eaves RJ, Mayo-Martin MB, Laube B, Jane DE, Monaghan DT. Structure-activity relationships for allosteric NMDA receptor inhibitors based on 2-naphthoic acid. Neuropharmacology. 62: 1730-6. PMID 22155206 DOI: 10.1016/j.neuropharm.2011.11.019  1
2012 Irvine MW, Costa BM, Dlaboga D, Culley GR, Hulse R, Scholefield CL, Atlason P, Fang G, Eaves R, Morley R, Mayo-Martin MB, Amici M, Bortolotto ZA, Donaldson L, Collingridge GL, ... ... Jane DE, et al. Piperazine-2,3-dicarboxylic acid derivatives as dual antagonists of NMDA and GluK1-containing kainate receptors. Journal of Medicinal Chemistry. 55: 327-41. PMID 22111545 DOI: 10.1021/jm201230z  1
2012 Chamberlain SE, Jane DE, Jones RS. Pre- and post-synaptic functions of kainate receptors at glutamate and GABA synapses in the rat entorhinal cortex. Hippocampus. 22: 555-76. PMID 21365713 DOI: 10.1002/hipo.20921  1
2012 Jane DE, Olverman HJ, Watkins JC. Agonists and competitive antagonists: Structure-activity and molecular modelling studies The Nmda Receptor. DOI: 10.1093/acprof:oso/9780192625021.003.0002  1
2011 Jullienne A, Montagne A, Orset C, Lesept F, Jane DE, Monaghan DT, Maubert E, Vivien D, Ali C. Selective inhibition of GluN2D-containing N-methyl-D-aspartate receptors prevents tissue plasminogen activator-promoted neurotoxicity both in vitro and in vivo. Molecular Neurodegeneration. 6: 68. PMID 21975018 DOI: 10.1186/1750-1326-6-68  1
2011 Alushin GM, Jane D, Mayer ML. Binding site and ligand flexibility revealed by high resolution crystal structures of GluK1 competitive antagonists. Neuropharmacology. 60: 126-34. PMID 20558186 DOI: 10.1016/j.neuropharm.2010.06.002  1
2011 Jane D. Kainate glutamate receptor Xpharm: the Comprehensive Pharmacology Reference. 1-15. DOI: 10.1016/B978-008055232-3.60375-7  1
2011 Jane D. AMPA glutamate receptor Xpharm: the Comprehensive Pharmacology Reference. 1-19. DOI: 10.1016/B978-008055232-3.60374-5  1
2011 Jane D. NMDA glutamate receptor Xpharm: the Comprehensive Pharmacology Reference. 1-14. DOI: 10.1016/B978-008055232-3.60373-3  1
2011 Jane D. Ionotropic glutamate receptors Xpharm: the Comprehensive Pharmacology Reference. 1-5. DOI: 10.1016/B978-008055232-3.60372-1  1
2010 Costa BM, Irvine MW, Fang G, Eaves RJ, Mayo-Martin MB, Skifter DA, Jane DE, Monaghan DT. A novel family of negative and positive allosteric modulators of NMDA receptors. The Journal of Pharmacology and Experimental Therapeutics. 335: 614-21. PMID 20858708 DOI: 10.1124/jpet.110.174144  1
2010 Atlason PT, Scholefield CL, Eaves RJ, Mayo-Martin MB, Jane DE, Molnár E. Mapping the ligand binding sites of kainate receptors: molecular determinants of subunit-selective binding of the antagonist [3H]UBP310. Molecular Pharmacology. 78: 1036-45. PMID 20837679 DOI: 10.1124/mol.110.067934  1
2010 Lennon SM, Rivero G, Matharu A, Howson PA, Jane DE, Roberts PJ, Kelly E. Metabotropic glutamate receptor mGlu2 is resistant to homologous agonist-induced desensitization but undergoes protein kinase C-mediated heterologous desensitization. European Journal of Pharmacology. 649: 29-37. PMID 20826132 DOI: 10.1016/j.ejphar.2010.08.038  1
2010 Suárez F, Zhao Q, Monaghan DT, Jane DE, Jones S, Gibb AJ. Functional heterogeneity of NMDA receptors in rat substantia nigra pars compacta and reticulata neurones. The European Journal of Neuroscience. 32: 359-67. PMID 20618827 DOI: 10.1111/j.1460-9568.2010.07298.x  1
2010 Lamy C, Goodchild SJ, Weatherall KL, Jane DE, Liégeois JF, Seutin V, Marrion NV. Allosteric block of KCa2 channels by apamin. The Journal of Biological Chemistry. 285: 27067-77. PMID 20562108 DOI: 10.1074/jbc.M110.110072  1
2010 Weatherall KL, Goodchild SJ, Jane DE, Marrion NV. Small conductance calcium-activated potassium channels: from structure to function. Progress in Neurobiology. 91: 242-55. PMID 20359520 DOI: 10.1016/j.pneurobio.2010.03.002  1
2009 Amici M, Doherty A, Jo J, Jane D, Cho K, Collingridge G, Dargan S. Neuronal calcium sensors and synaptic plasticity Biochemical Society Transactions. 37: 1359-1363. PMID 19909276 DOI: 10.1042/BST0371359  1
2009 Sigalas C, Mayo-Martin MB, Jane DE, Sitsapesan R. Ca2+-calmodulin increases RyR2 open probability yet reduces ryanoid association with RyR2. Biophysical Journal. 97: 1907-16. PMID 19804721 DOI: 10.1016/j.bpj.2009.07.027  1
2009 Costa BM, Feng B, Tsintsadze TS, Morley RM, Irvine MW, Tsintsadze V, Lozovaya NA, Jane DE, Monaghan DT. N-methyl-D-aspartate (NMDA) receptor NR2 subunit selectivity of a series of novel piperazine-2,3-dicarboxylate derivatives: preferential blockade of extrasynaptic NMDA receptors in the rat hippocampal CA3-CA1 synapse. The Journal of Pharmacology and Experimental Therapeutics. 331: 618-26. PMID 19684252 DOI: 10.1124/jpet.109.156752  1
2009 Nisticò R, Dargan S, Fitzjohn SM, Lodge D, Jane DE, Collingridge GL, Bortolotto ZA. GLUK1 receptor antagonists and hippocampal mossy fiber function. International Review of Neurobiology. 85: 13-27. PMID 19607958 DOI: 10.1016/S0074-7742(09)85002-2  1
2009 Ahmed AH, Thompson MD, Fenwick MK, Romero B, Loh AP, Jane DE, Sondermann H, Oswald RE. Mechanisms of antagonism of the GluR2 AMPA receptor: structure and dynamics of the complex of two willardiine antagonists with the glutamate binding domain. Biochemistry. 48: 3894-903. PMID 19284741 DOI: 10.1021/bi900107m  1
2009 Jaskolski F, Mayo-Martin B, Jane D, Henley JM. Dynamin-dependent membrane drift recruits AMPA receptors to dendritic spines. The Journal of Biological Chemistry. 284: 12491-503. PMID 19269965 DOI: 10.1074/jbc.M808401200  1
2009 Jane DE, Lodge D, Collingridge GL. Kainate receptors: pharmacology, function and therapeutic potential. Neuropharmacology. 56: 90-113. PMID 18793656 DOI: 10.1016/j.neuropharm.2008.08.023  1
2009 Dargan SL, Clarke VR, Alushin GM, Sherwood JL, Nisticò R, Bortolotto ZA, Ogden AM, Bleakman D, Doherty AJ, Lodge D, Mayer ML, Fitzjohn SM, Jane DE, Collingridge GL. ACET is a highly potent and specific kainate receptor antagonist: characterisation and effects on hippocampal mossy fibre function. Neuropharmacology. 56: 121-30. PMID 18789344 DOI: 10.1016/j.neuropharm.2008.08.016  1
2009 Perrais D, Pinheiro PS, Jane DE, Mulle C. Antagonism of recombinant and native GluK3-containing kainate receptors. Neuropharmacology. 56: 131-40. PMID 18761361 DOI: 10.1016/j.neuropharm.2008.08.002  1
2008 Stanger HL, Alford R, Jane DE, Cunningham MO. The role of GLU K5-containing kainate receptors in entorhinal cortex gamma frequency oscillations. Neural Plasticity. 2008: 401645. PMID 19043593 DOI: 10.1155/2008/401645  1
2008 Harney SC, Jane DE, Anwyl R. Extrasynaptic NR2D-containing NMDARs are recruited to the synapse during LTP of NMDAR-EPSCs. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 11685-94. PMID 18987204 DOI: 10.1523/JNEUROSCI.3035-08.2008  1
2008 Maltsev AS, Ahmed AH, Fenwick MK, Jane DE, Oswald RE. Mechanism of partial agonism at the GluR2 AMPA receptor: Measurements of lobe orientation in solution. Biochemistry. 47: 10600-10. PMID 18795801 DOI: 10.1021/bi800843c  1
2008 Brothwell SL, Barber JL, Monaghan DT, Jane DE, Gibb AJ, Jones S. NR2B- and NR2D-containing synaptic NMDA receptors in developing rat substantia nigra pars compacta dopaminergic neurones. The Journal of Physiology. 586: 739-50. PMID 18033813 DOI: 10.1113/jphysiol.2007.144618  1
2007 Dolman NP, More JC, Alt A, Knauss JL, Pentikäinen OT, Glasser CR, Bleakman D, Mayer ML, Collingridge GL, Jane DE. Synthesis and pharmacological characterization of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonists. Journal of Medicinal Chemistry. 50: 1558-70. PMID 17348638 DOI: 10.1021/jm061041u  1
2007 Ahmed AH, Loh AP, Jane DE, Oswald RE. Dynamics of the S1S2 glutamate binding domain of GluR2 measured using 19F NMR spectroscopy. The Journal of Biological Chemistry. 282: 12773-84. PMID 17337449 DOI: 10.1074/jbc.M610077200  1
2007 Huxter JR, Zinyuk LE, Roloff Ev, Clarke VR, Dolman NP, More JC, Jane DE, Collingridge GL, Muller RU. Inhibition of kainate receptors reduces the frequency of hippocampal theta oscillations. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 2212-23. PMID 17329418 DOI: 10.1523/JNEUROSCI.3954-06.2007  1
2006 Dolman NP, More JC, Alt A, Knauss JL, Troop HM, Bleakman D, Collingridge GL, Jane DE. Structure-activity relationship studies on N3-substituted willardiine derivatives acting as AMPA or kainate receptor antagonists. Journal of Medicinal Chemistry. 49: 2579-92. PMID 16610801 DOI: 10.1021/jm051086f  1
2006 Barker GR, Warburton EC, Koder T, Dolman NP, More JC, Aggleton JP, Bashir ZI, Auberson YP, Jane DE, Brown MW. The different effects on recognition memory of perirhinal kainate and NMDA glutamate receptor antagonism: implications for underlying plasticity mechanisms. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 3561-6. PMID 16571764 DOI: 10.1523/JNEUROSCI.3154-05.2006  1
2006 Mayer ML, Ghosal A, Dolman NP, Jane DE. Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 2852-61. PMID 16540562 DOI: 10.1523/JNEUROSCI.0123-06.2005  1
2006 Watkins JC, Jane DE. The glutamate story. British Journal of Pharmacology. 147: S100-8. PMID 16402093 DOI: 10.1038/sj.bjp.0706444  1
2005 Dolman NP, Troop HM, More JC, Alt A, Knauss JL, Nistico R, Jack S, Morley RM, Bortolotto ZA, Roberts PJ, Bleakman D, Collingridge GL, Jane DE. Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors. Journal of Medicinal Chemistry. 48: 7867-81. PMID 16302825 DOI: 10.1021/jm050584l  1
2005 Bortolotto ZA, Nistico R, More JC, Jane DE, Collingridge GL. Kainate receptors and mossy fiber LTP. Neurotoxicology. 26: 769-77. PMID 15939476 DOI: 10.1016/j.neuro.2005.02.004  1
2005 Morley RM, Tse HW, Feng B, Miller JC, Monaghan DT, Jane DE. Synthesis and pharmacology of N1-substituted piperazine-2,3-dicarboxylic acid derivatives acting as NMDA receptor antagonists. Journal of Medicinal Chemistry. 48: 2627-37. PMID 15801853 DOI: 10.1021/jm0492498  1
2005 Kinarsky L, Feng B, Skifter DA, Morley RM, Sherman S, Jane DE, Monaghan DT. Identification of subunit- and antagonist-specific amino acid residues in the N-Methyl-D-aspartate receptor glutamate-binding pocket. The Journal of Pharmacology and Experimental Therapeutics. 313: 1066-74. PMID 15743930 DOI: 10.1124/jpet.104.082990  1
2005 Feng B, Morley RM, Jane DE, Monaghan DT. The effect of competitive antagonist chain length on NMDA receptor subunit selectivity. Neuropharmacology. 48: 354-9. PMID 15721167 DOI: 10.1016/j.neuropharm.2004.11.004  1
2005 Monaghan DT, More JCA, Feng B, Jane DE. Glutamate receptors ionotropic Dopamine and Glutamate in Psychiatric Disorders. 79-116. DOI: 10.1007/978-1-59259-852-6_4  1
2004 More JC, Nistico R, Dolman NP, Clarke VR, Alt AJ, Ogden AM, Buelens FP, Troop HM, Kelland EE, Pilato F, Bleakman D, Bortolotto ZA, Collingridge GL, Jane DE. Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist. Neuropharmacology. 47: 46-64. PMID 15165833 DOI: 10.1016/j.neuropharm.2004.03.005  1
2004 Mundell SJ, Pula G, More JC, Jane DE, Roberts PJ, Kelly E. Activation of cyclic AMP-dependent protein kinase inhibits the desensitization and internalization of metabotropic glutamate receptors 1a and 1b. Molecular Pharmacology. 65: 1507-16. PMID 15155843 DOI: 10.1124/mol.65.6.1507  1
2004 Feng B, Tse HW, Skifter DA, Morley R, Jane DE, Monaghan DT. Structure-activity analysis of a novel NR2C/NR2D-preferring NMDA receptor antagonist: 1-(phenanthrene-2-carbonyl) piperazine-2,3-dicarboxylic acid. British Journal of Pharmacology. 141: 508-16. PMID 14718249 DOI: 10.1038/sj.bjp.0705644  1
2003 Miller JC, Howson PA, Conway SJ, Williams RV, Clark BP, Jane DE. Phenylglycine derivatives as antagonists of group III metabotropic glutamate receptors expressed on neonatal rat primary afferent terminals. British Journal of Pharmacology. 139: 1523-31. PMID 12922940 DOI: 10.1038/sj.bjp.0705377  1
2003 Lee JJ, Jane DE, Croucher MJ. Anticonvulsant dicarboxyphenylglycines differentially modulate excitatory amino acid release in the rat cerebral cortex. Brain Research. 977: 119-23. PMID 12788521 DOI: 10.1016/S0006-8993(03)02657-X  1
2003 Howson PA, Jane DE. Actions of LY341495 on metabotropic glutamate receptor-mediated responses in the neonatal rat spinal cord. British Journal of Pharmacology. 139: 147-55. PMID 12746233 DOI: 10.1038/sj.bjp.0705230  1
2003 More JC, Troop HM, Dolman NP, Jane DE. Structural requirements for novel willardiine derivatives acting as AMPA and kainate receptor antagonists. British Journal of Pharmacology. 138: 1093-100. PMID 12684265 DOI: 10.1038/sj.bjp.0705148  1
2002 More JC, Troop HM, Jane DE. The novel antagonist 3-CBW discriminates between kainate receptors expressed on neonatal rat motoneurones and those on dorsal root C-fibres. British Journal of Pharmacology. 137: 1125-33. PMID 12429586 DOI: 10.1038/sj.bjp.0704957  1
2002 Pothecary CA, Jane DE, Salt TE. Reduction of excitatory transmission in the retino-collicular pathway via selective activation of mGlu8 receptors by DCPG. Neuropharmacology. 43: 231-4. PMID 12213277 DOI: 10.1016/S0028-3908(02)00077-1  1
2002 Conway SJ, Miller JC, Bond AD, Clarkc BP, Jane DE. Synthesis and biological evaluation of phospholane and dihydrophosphole analogues of the glutamate receptor agonist AP4 Journal of the Chemical Society. Perkin Transactions 1. 1625-1627.  1
2001 Thomas LS, Jane DE, Gasparini F, Croucher MJ. Glutamate release inhibiting properties of the novel mGlu(5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP): complementary in vitro and in vivo evidence. Neuropharmacology. 41: 523-7. PMID 11543773 DOI: 10.1016/S0028-3908(01)00091-0  1
2001 Moldrich RX, Beart PM, Jane DE, Chapman AG, Meldrum BS. Anticonvulsant activity of 3,4-dicarboxyphenylglycines in DBA/2 mice. Neuropharmacology. 40: 732-5. PMID 11311902 DOI: 10.1016/S0028-3908(01)00002-8  1
2001 Conway SJ, Miller JC, Howson PA, Clark BP, Jane DE. Synthesis of phenylglycine derivatives as potent and selective antagonists of group III metabotropic glutamate receptors. Bioorganic & Medicinal Chemistry Letters. 11: 777-80. PMID 11277518 DOI: 10.1016/S0960-894X(01)00052-X  1
2001 Thomas NK, Wright RA, Howson PA, Kingston AE, Schoepp DD, Jane DE. (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord. Neuropharmacology. 40: 311-8. PMID 11166323 DOI: 10.1016/S0028-3908(00)00169-6  1
2000 Thomas LS, Jane DE, Harris JR, Croucher MJ. Metabotropic glutamate autoreceptors of the mGlu(5) subtype positively modulate neuronal glutamate release in the rat forebrain in vitro. Neuropharmacology. 39: 1554-66. PMID 10854900 DOI: 10.1016/S0028-3908(99)00223-3  1
2000 Hrabetova S, Serrano P, Blace N, Tse HW, Skifter DA, Jane DE, Monaghan DT, Sacktor TC. Distinct NMDA receptor subpopulations contribute to long-term potentiation and long-term depression induction. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: RC81. PMID 10827202  1
2000 Christie JM, Jane DE, Monaghan DT. Native N-methyl-D-aspartate receptors containing NR2A and NR2B subunits have pharmacologically distinct competitive antagonist binding sites. The Journal of Pharmacology and Experimental Therapeutics. 292: 1169-74. PMID 10688637  1
1999 Schoepp DD, Jane DE, Monn JA. Pharmacological agents acting at subtypes of metabotropic glutamate receptors. Neuropharmacology. 38: 1431-76. PMID 10530808 DOI: 10.1016/S0028-3908(99)00092-1  1
1999 Doherty AJ, Collingridge GL, Jane DE. Antagonist activity of alpha-substituted 4-carboxyphenylglycine analogues at group I metabotropic glutamate receptors expressed in CHO cells. British Journal of Pharmacology. 126: 205-10. PMID 10051137 DOI: 10.1038/sj.bjp.0702297  1
1998 Thomas NK, Hawkins LM, Miller JC, Troop HM, Roberts PJ, Jane DE. Pharmacological differentiation of kainate receptors on neonatal rat spinal motoneurones and dorsal roots. Neuropharmacology. 37: 1223-37. PMID 9849660 DOI: 10.1016/S0028-3908(98)00124-5  1
1998 Brown JC, Tse HW, Skifter DA, Christie JM, Andaloro VJ, Kemp MC, Watkins JC, Jane DE, Monaghan DT. [3H]homoquinolinate binds to a subpopulation of NMDA receptors and to a novel binding site. Journal of Neurochemistry. 71: 1464-70. PMID 9751179  1
1998 Attwell PJ, Singh Kent N, Jane DE, Croucher MJ, Bradford HF. Anticonvulsant and glutamate release-inhibiting properties of the highly potent metabotropic glutamate receptor agonist (2S,2'R, 3'R)-2-(2',3'-dicarboxycyclopropyl)glycine (DCG-IV). Brain Research. 805: 138-43. PMID 9733953 DOI: 10.1016/S0006-8993(98)00698-2  1
1998 Hussain SA, Jane DE, Taberner PV. Lack of inhibition of human plasma cholinesterase and red cell acetylcholinesterase by antimony compounds including stibine. Human & Experimental Toxicology. 17: 140-3. PMID 9587781 DOI: 10.1191/096032798678908422  1
1997 Palmer MJ, Irving AJ, Seabrook GR, Jane DE, Collingridge GL. The group I mGlu receptor agonist DHPG induces a novel form of LTD in the CA1 region of the hippocampus. Neuropharmacology. 36: 1517-32. PMID 9517422 DOI: 10.1016/S0028-3908(97)00181-0  1
1997 Thomas NK, Clayton P, Jane DE. Dicarboxyphenylglycines antagonize AMPA- but not kainate-induced depolarizations in neonatal rat motoneurones. European Journal of Pharmacology. 338: 111-6. PMID 9455991 DOI: 10.1016/S0014-2999(97)81937-1  1
1997 Jane DE, Hoo K, Kamboj R, Deverill M, Bleakman D, Mandelzys A. Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes. Journal of Medicinal Chemistry. 40: 3645-50. PMID 9357531 DOI: 10.1021/jm9702387  1
1997 Wilson C, Howard JA, Jane DE, Sunter DC, Watkins JC. Absolute configuration of (+)-alpha-methyl-4-carboxyphenylglycine (MCPG), a metabotropic glutamate receptor antagonist. Acta Crystallographica. Section C, Crystal Structure Communications. 53: 909-11. PMID 9241811  1
1997 Tang E, Yip PK, Chapman AG, Jane DE, Meldrum BS. Prolonged anticonvulsant action of glutamate metabotropic receptor agonists in inferior colliculus of genetically epilepsy-prone rats. European Journal of Pharmacology. 327: 109-15. PMID 9200548 DOI: 10.1016/S0014-2999(97)89649-5  1
1997 Abdul-Ghani AS, Attwell PJ, Singh Kent N, Bradford HF, Croucher MJ, Jane DE. Anti-epileptogenic and anticonvulsant activity of L-2-amino-4-phosphonobutyrate, a presynaptic glutamate receptor agonist. Brain Research. 755: 202-12. PMID 9175888 DOI: 10.1016/S0006-8993(97)00098-X  1
1997 Cao CQ, Tse HW, Jane DE, Evans RH, Headley PM. Antagonism of mGlu receptors and potentiation of EPSCs at rat spinal motoneurones in vitro. Neuropharmacology. 36: 313-8. PMID 9175609 DOI: 10.1016/S0028-3908(96)00180-3  1
1997 Doherty AJ, Palmer MJ, Henley JM, Collingridge GL, Jane DE. (RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but no mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus. Neuropharmacology. 36: 265-7. PMID 9144665 DOI: 10.1016/S0028-3908(97)00001-4  1
1997 Thoreson WB, Gottesman J, Jane DE, Tse HW, Watkins JC, Miller RF. Two phenylglycine derivatives antagonize responses to L-AP4 in ON bipolar cells of the amphibian retina. Neuropharmacology. 36: 13-20. PMID 9144637 DOI: 10.1016/S0028-3908(96)00164-5  1
1997 Cao CQ, Tse HW, Jane DE, Evans RH, Headley PM. Metabotropic glutamate receptor antagonists, like GABA(B) antagonists, potentiate dorsal root-evoked excitatory synaptic transmission at neonatal rat spinal motoneurons in vitro. Neuroscience. 78: 243-50. PMID 9135104 DOI: 10.1016/S0306-4522(96)00579-9  1
1997 Wilson C, Howard JAK, Jane DE, Sunter DC, Watkins JC. Absolute configuration of (+)-α-methyl-4-carboxyphenylglycine (MCPG), a metabotropic glutamate receptor antagonist Acta Crystallographica Section C: Crystal Structure Communications. 53: 909-911.  1
1996 Jane DE, Thomas NK, Tse HW, Watkins JC. Potent antagonists at the L-AP4- and (1S,3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cord. Neuropharmacology. 35: 1029-35. PMID 9121605 DOI: 10.1016/S0028-3908(96)00048-2  1
1996 Jane DE, Chalmers DJ, Howard JA, Kilpatrick IC, Sunter DC, Thompson GA, Udvarhelyi PM, Wilson C, Watkins JC. Diastereoselective synthesis of all four isomers of 3-(4-chlorophenyl) glutamic acid: identification of the isomers responsible for the potentiation of L-homocysteic acid-evoked depolarizations in neonatal rat motoneurons. Journal of Medicinal Chemistry. 39: 4738-43. PMID 8941386 DOI: 10.1021/jm960382c  1
1996 Toms NJ, Jane DE, Kemp MC, Bedingfield JS, Roberts PJ. The effects of (RS)-alpha-cyclopropyl-4-phosphonophenylglycine ((RS)-CPPG), a potent and selective metabotropic glutamate receptor antagonist. British Journal of Pharmacology. 119: 851-4. PMID 8922731  1
1996 Thomas NK, Jane DE, Tse HW, Watkins JC. alpha-Methyl derivatives of serine-O-phosphate as novel, selective competitive metabotropic glutamate receptor antagonists. Neuropharmacology. 35: 637-42. PMID 8887973 DOI: 10.1016/S0028-3908(96)00019-6  1
1996 Kemp MC, Jane DE, Tse HW, Roberts PJ. Agonists of cyclic AMP-coupled metabotropic glutamate receptors in adult rat cortical slices. European Journal of Pharmacology. 309: 79-85. PMID 8864697 DOI: 10.1016/0014-2999(96)00314-7  1
1996 Bedingfield JS, Jane DE, Kemp MC, Toms NJ, Roberts PJ. Novel potent selective phenylglycine antagonists of metabotropic glutamate receptors. European Journal of Pharmacology. 309: 71-8. PMID 8864696 DOI: 10.1016/0014-2999(96)00313-5  1
1996 Sekiyama N, Hayashi Y, Nakanishi S, Jane DE, Tse HW, Birse EF, Watkins JC. Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. British Journal of Pharmacology. 117: 1493-503. PMID 8730745  1
1996 Bushell TJ, Jane DE, Tse HW, Watkins JC, Garthwaite J, Collingridge GL. Pharmacological antagonism of the actions of group II and III mGluR agonists in the lateral perforant path of rat hippocampal slices. British Journal of Pharmacology. 117: 1457-62. PMID 8730739  1
1996 Jane DE, Pittaway K, Sunter DC, Thomas NK, Tse HW. Phosphono substituted amino acids as selective metabotropic glutamate receptor antagonists Phosphorus, Sulfur and Silicon and Related Elements. 109: 313-316.  1
1995 Chalmers DJ, Jane DE, Sunter DC, Thompson GA, Udvarhelyi PM, Kilpatrick IC, Watkins JC. Differential actions of 3-(4-chlorophenyl) glutamic acid stereoisomers and L-trans-pyrrolidine-2,4-dicarboxylic acid upon L-homocysteic acid- and L-glutamic acid-induced responses from rat spinal motoneurones. Neuropharmacology. 34: 1589-95. PMID 8788956 DOI: 10.1016/0028-3908(95)00124-7  1
1995 Bedingfield JS, Kemp MC, Jane DE, Tse HW, Roberts PJ, Watkins JC. Structure-activity relationships for a series of phenylglycine derivatives acting at metabotropic glutamate receptors (mGluRs). British Journal of Pharmacology. 116: 3323-9. PMID 8719814  1
1995 Toms NJ, Jane DE, Tse HW, Roberts PJ. Characterization of metabotropic glutamate receptor-stimulated phosphoinositide hydrolysis in rat cultured cerebellar granule cells. British Journal of Pharmacology. 116: 2824-7. PMID 8680712  1
1995 Hawkins LM, Beaver KM, Jane DE, Taylor PM, Sunter DC, Roberts PJ. Characterization of the pharmacology and regional distribution of (S)-[3H]-5-fluorowillardiine binding in rat brain. British Journal of Pharmacology. 116: 2033-9. PMID 8640342  1
1995 Attwell PJ, Kaura S, Sigala G, Bradford HF, Croucher MJ, Jane DE, Watkins JC. Blockade of both epileptogenesis and glutamate release by (1S,3S)-ACPD, a presynaptic glutamate receptor agonist. Brain Research. 698: 155-62. PMID 8581475 DOI: 10.1016/0006-8993(95)00886-U  1
1995 Vignes M, Clarke VR, Davies CH, Chambers A, Jane DE, Watkins JC, Collingridge GL. Pharmacological evidence for an involvement of group II and group III mGluRs in the presynaptic regulation of excitatory synaptic responses in the CA1 region of rat hippocampal slices. Neuropharmacology. 34: 973-82. PMID 8532178 DOI: 10.1016/0028-3908(95)00093-L  1
1995 Jane DE, Pittaway K, Sunter DC, Thomas NK, Watkins JC. New phenylglycine derivatives with potent and selective antagonist activity at presynaptic glutamate receptors in neonatal rat spinal cord. Neuropharmacology. 34: 851-6. PMID 8532166 DOI: 10.1016/0028-3908(95)00063-C  1
1995 Davies CH, Clarke VR, Jane DE, Collingridge GL. Pharmacology of postsynaptic metabotropic glutamate receptors in rat hippocampal CA1 pyramidal neurones. British Journal of Pharmacology. 116: 1859-69. PMID 8528571  1
1995 Bushell TJ, Jane DE, Tse HW, Watkins JC, Davies CH, Garthwaite J, Collingridge GL. Antagonism of the synaptic depressant actions of L-AP4 in the lateral perforant path by MAP4. Neuropharmacology. 34: 239-41. PMID 7617150 DOI: 10.1016/0028-3908(95)00012-U  1
1995 Hawkins LM, Beaver KM, Jane DE, Taylor PM, Sunter DC, Roberts PJ. Binding of the new radioligand (S)-[3H]AMPA to rat brain synaptic membranes: effects of a series of structural analogues of the non-NMDA receptor agonist willardiine. Neuropharmacology. 34: 405-10. PMID 7566471 DOI: 10.1016/0028-3908(94)00157-N  1
1994 Hayashi Y, Sekiyama N, Nakanishi S, Jane DE, Sunter DC, Birse EF, Udvarhelyi PM, Watkins JC. Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor subtypes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 3370-7. PMID 8182479  1
1994 Gaoni Y, Chapman AG, Parvez N, Pook PC, Jane DE, Watkins JC. Synthesis, NMDA receptor antagonist activity, and anticonvulsant action of 1-aminocyclobutanecarboxylic acid derivatives. Journal of Medicinal Chemistry. 37: 4288-96. PMID 7996540  1
1994 Jane DE, Jones PL, Pook PC, Tse HW, Watkins JC. Actions of two new antagonists showing selectivity for different sub-types of metabotropic glutamate receptor in the neonatal rat spinal cord. British Journal of Pharmacology. 112: 809-16. PMID 7921606  1
1994 Wong LA, Mayer ML, Jane DE, Watkins JC. Willardiines differentiate agonist binding sites for kainate- versus AMPA-preferring glutamate receptors in DRG and hippocampal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 3881-97. PMID 7515954  1
1993 Bashir ZI, Bortolotto ZA, Davies CH, Berretta N, Irving AJ, Seal AJ, Henley JM, Jane DE, Watkins JC, Collingridge GL. Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptors. Nature. 363: 347-50. PMID 8388549 DOI: 10.1038/363347a0  1
1993 Eaton SA, Jane DE, Jones PL, Porter RH, Pook PC, Sunter DC, Udvarhelyi PM, Roberts PJ, Salt TE, Watkins JC. Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine and (RS)-alpha-methyl-4-carboxyphenylglycine. European Journal of Pharmacology. 244: 195-7. PMID 8381746 DOI: 10.1016/0922-4106(93)90028-8  1
1993 Bashir ZI, Jane DE, Sunter DC, Watkins JC, Collingridge GL. Metabotropic glutamate receptors contribute to the induction of long-term depression in the CA1 region of the hippocampus. European Journal of Pharmacology. 239: 265-6. PMID 8223907 DOI: 10.1016/0014-2999(93)91009-C  1
1993 Jane DE, Jones PL, Pook PC, Salt TE, Sunter DC, Watkins JC. Stereospecific antagonism by (+)-alpha-methyl-4-carboxyphenylglycine (MCPG) of (1S,3R)-ACPD-induced effects in neonatal rat motoneurones and rat thalamic neurones. Neuropharmacology. 32: 725-7. PMID 7689710 DOI: 10.1016/0028-3908(93)90088-K  1
1993 Birse EF, Eaton SA, Jane DE, Jones PL, Porter RH, Pook PC, Sunter DC, Udvarhelyi PM, Wharton B, Roberts PJ. Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system. Neuroscience. 52: 481-8. PMID 7680790 DOI: 10.1016/0306-4522(93)90400-A  1
1992 Patneau DK, Mayer ML, Jane DE, Watkins JC. Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 12: 595-606. PMID 1371315  1
1992 Porter RH, Roberts PJ, Jane DE, Watkins JC. (S)-homoquisqualate: a potent agonist at the glutamate metabotropic receptor. British Journal of Pharmacology. 106: 509-10. PMID 1324071  1
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