Jeffrey Clifton Watkins, PhD - Related publications

Affiliations: 
Pharmacology University of Bristol, Bristol, England, United Kingdom 
Area:
Glutamate pharmacology and medicinal chemistry
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50 most relevant papers in past 60 days:
Year Citation  Score
2020 Al Noman MA, Kyzer J, Chung SSW, Wolgemuth DJ, Georg GI. Retinoic acid receptor antagonists for male contraception: Current status. Biology of Reproduction. PMID 32671394 DOI: 10.1093/biolre/ioaa122   
2020 Yao D, Li J, Yoshida M, Sessle BJ. NMDA and Purinergic Processes Modulate Neck Muscle Activity Evoked by Noxious Stimulation of Dura. Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. PMID 32531859 DOI: 10.1111/jop.13072   
2020 Abbott JA, Popescu GK. Hydroxynorketamine Blocks NMDA Receptor Currents by Binding to Closed Receptors. Molecular Pharmacology. PMID 32606205 DOI: 10.1124/mol.120.119784   
2020 Milla-Cruz JJ, Mena-Avila E, Calvo JR, Hochman S, Villalón CM, Quevedo JN. The activation of D and D receptor subtypes inhibits pathways mediating primary afferent depolarization (PAD) in the mouse spinal cord. Neuroscience Letters. 135257. PMID 32682848 DOI: 10.1016/j.neulet.2020.135257   
2020 Salazar H, Mischke S, Plested AJR. Measurements of the Timescale and Conformational Space of AMPA Receptor Desensitization. Biophysical Journal. PMID 32559412 DOI: 10.1016/j.bpj.2020.05.029   
2020 Gallagher CI, Sheipouri D, Shimmon S, Rawling T, Vandenberg RJ. Identification of N-acyl amino acids that are positive allosteric modulators of glycine receptors. Biochemical Pharmacology. 114117. PMID 32579961 DOI: 10.1016/j.bcp.2020.114117   
2020 Chen BP, Huang XX, Dong DM, Wu H, Zhu TQ, Wang BF. The role of NMDA receptors in rat propofol self-administration. Bmc Anesthesiology. 20: 149. PMID 32539742 DOI: 10.1186/s12871-020-01056-0   
2020 Nikitin VP, Solntseva SV, Kozyrev SA. Peculiarities in Synthesis of Proteins Implicated in Memory Reconsolidation and Induction of Amnesia. Bulletin of Experimental Biology and Medicine. 169: 187-191. PMID 32651811 DOI: 10.1007/s10517-020-04847-0   
2020 Natter J, Michel B. Memantine misuse and social networks: A content analysis of Internet self-reports. Pharmacoepidemiology and Drug Safety. PMID 32602152 DOI: 10.1002/pds.5070   
2020 Motawe ZY, Abdelmaboud SS, Cuevas J, Breslin JW. PRE-084 as a tool to uncover potential therapeutic applications for selective sigma-1 receptor activation. The International Journal of Biochemistry & Cell Biology. 126: 105803. PMID 32668330 DOI: 10.1016/j.biocel.2020.105803   
2020 Intagliata S, Sharma A, King TI, Mesangeau C, Seminerio M, Chin FT, Wilson LL, Matsumoto RR, McLaughlin JP, Avery BA, McCurdy CR. Discovery of a Highly Selective Sigma-2 Receptor Ligand, 1-(4-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-3-methyl-1H-benzo[d]imidazol-2(3H)-one (CM398), with Drug-Like Properties and Antinociceptive Effects In Vivo. The Aaps Journal. 22: 94. PMID 32691179 DOI: 10.1208/s12248-020-00472-x   
2020 Liu X, Guo L, Liang C. [Research progress on electroencephalogram characteristics of anti-N-methyl-D-aspartate receptor encephalitis]. Zhejiang Da Xue Xue Bao. Yi Xue Ban = Journal of Zhejiang University. Medical Sciences. 49: 118-123. PMID 32621409   
2020 Pflüger P, Regner GG, Luft JG, Gonçalves DA, Krebs C, Fontenla JA, Pereira P. Gamma-decanolactone attenuates acute and chronic seizures in mice: a possible role of adenosine A1 receptors. Behavioural Pharmacology. PMID 32701527 DOI: 10.1097/FBP.0000000000000554   
2020 Sakiyama Y, Matsuura E, Shigehisa A, Hamada Y, Dozono M, Nozuma S, Nakamura T, Higashi K, Hashiguchi A, Takahashi Y, Takashima H. Cryptococcus Meningitis Can Co-occur with Anti-NMDA Receptor Encephalitis. Internal Medicine (Tokyo, Japan). PMID 32522922 DOI: 10.2169/internalmedicine.4629-20   
2020 Zeng W, Cao L, Zheng J, Yu L. Clinical characteristics and long-term prognosis of relapsing anti-N-methyl-D-aspartate receptor encephalitis: a retrospective, multicenter, self-controlled study. Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. PMID 32601745 DOI: 10.1007/s10072-020-04482-7   
2020 Ono H, Shimizu T, Zou S, Yamamoto M, Shimizu Y, Aratake T, Hamada T, Nagao Y, Shimizu S, Higashi Y, Saito M. Brain nitric oxide induces facilitation of the micturition reflex through brain glutamatergic receptors in rats. Neurourology and Urodynamics. PMID 32558992 DOI: 10.1002/nau.24440   
2020 Song M, Yan R, Zhang Y, Guo D, Zhou N, Deng X. Design, synthesis, and anticonvulsant effects evaluation of nonimidazole histamine H receptor antagonists/inverse agonists containing triazole moiety. Journal of Enzyme Inhibition and Medicinal Chemistry. 35: 1310-1321. PMID 32529860 DOI: 10.1080/14756366.2020.1774573   
2020 Richendrfer HA, Levy MM, Elsaid KA, Schmidt TA, Zhang L, Cabezas R, Jay GD. Recombinant Human Proteoglycan-4 Mediates Interleukin-6 Response in Both Human and Mouse Endothelial Cells Induced Into a Sepsis Phenotype. Critical Care Explorations. 2: e0126. PMID 32695993 DOI: 10.1097/CCE.0000000000000126   
2020 Brimson JM, Akula KK, Abbas H, Ferry DR, Kulkarni SK, Russell ST, Tisdale MJ, Tencomnao T, Safrany ST. Simple ammonium salts acting on sigma-1 receptors yield potential treatments for cancer and depression. Scientific Reports. 10: 9251. PMID 32514120 DOI: 10.1038/s41598-020-65849-6   
2020 Currò D, Navarra P, Samengo I, Martire M. P2X7 receptors exert a permissive effect on the activation of presynaptic AMPA receptors in rat trigeminal caudal nucleus glutamatergic nerve terminals. The Journal of Headache and Pain. 21: 83. PMID 32615921 DOI: 10.1186/s10194-020-01153-y   
2020 Tian J, He Y, Deuther-Conrad W, Fu H, Xie F, Zhang Y, Wang T, Zhang X, Zhang J, Brust P, Huang Y, Jia H. Synthesis and evaluation of new 1-oxa-8-azaspiro[4.5]decane derivatives as candidate radioligands for sigma-1 receptors. Bioorganic & Medicinal Chemistry. 28: 115560. PMID 32616183 DOI: 10.1016/j.bmc.2020.115560   
2020 Andoh T, Suzuki K, Konno M, Tsuneyama K, Kuraishi Y. Pharmacological Characterization of a Novel Mouse Model of Cholestatic Pruritus. Biological & Pharmaceutical Bulletin. 43: 1111-1117. PMID 32612073 DOI: 10.1248/bpb.b20-00097   
2020 Lillo A, Martínez-Pinilla E, Reyes-Resina I, Navarro G, Franco R. Adenosine A and A Receptors Are Able to Interact with Each Other. A Further Piece in the Puzzle of Adenosine Receptor-Mediated Signaling. International Journal of Molecular Sciences. 21. PMID 32709103 DOI: 10.3390/ijms21145070   
2020 Jiang WN, Jing X, Li M, Deng H, Jiang T, Xiong KZ, Chen Y, Wang XF, Wang QJ. Corydaline and l-tetrahydropalmatine attenuate morphine-induced conditioned place preference and the changes in dopamine D and GluA1 AMPA receptor expression in rats. European Journal of Pharmacology. 173397. PMID 32717192 DOI: 10.1016/j.ejphar.2020.173397   
2020 Fischer JP, Els-Heindl S, Beck-Sickinger AG. Adrenomedullin - Current Perspective on a Peptide Hormone with Significant Therapeutic Potential. Peptides. 170347. PMID 32569606 DOI: 10.1016/j.peptides.2020.170347   
2020 Chou TH, Tajima N, Romero-Hernandez A, Furukawa H. Structural Basis of Functional Transitions in Mammalian NMDA Receptors. Cell. PMID 32610085 DOI: 10.1016/j.cell.2020.05.052   
2020 Saleh HA, Raafat KM, Temraz TA, Noureldin N, Breitinger HG, Breitinger U. Sarcophine and (7S, 8R)-Dihydroxydeepoxysarcophine from the Red Sea Soft Coral Sarcophyton glaucum as in vitro and in vivo Modulators of Glycine Receptors. Neurotoxicology. PMID 32702364 DOI: 10.1016/j.neuro.2020.07.002   
2020 Yang X, Dilweg MA, Osemwengie D, Burggraaff L, van der Es D, Heitman LH, IJzerman AP. Design and Pharmacological Profile of a Novel Covalent Partial Agonist for the Adenosine A Receptor. Biochemical Pharmacology. 114144. PMID 32653590 DOI: 10.1016/j.bcp.2020.114144   
2020 Sánchez-Melgar A, Albasanz JL, Griñán-Ferré C, Pallàs M, Martín M. Adenosine and Metabotropic Glutamate Receptors Are Present in Blood Serum and Exosomes from SAMP8 Mice: Modulation by Aging and Resveratrol. Cells. 9. PMID 32645849 DOI: 10.3390/cells9071628   
2020 Bucknell SJ, Ator MA, Brown A, Brown J, Cansfield A, Cansfield J, Christopher J, Congreve M, Cseke G, Deflorian F, Jones C, Mason JS, O'Brien A, Ott GR, Pickworth M, et al. Structure-Based Drug Discovery of N-((R)-3-(7-Methyl-1H-indazol-5-yl)-1-oxo-1-(((S)-1-oxo-3-(piperidin-4-yl)-1-(4-(pyridin-4-yl)piperazin-1-yl)propan-2-yl)amino)propan-2-yl)-2'-oxo-1',2'-dihydrospiro[piperidine-4,4'-pyrido[2,3-d][1,3]oxazine]-1-carboxamide (HTL22562): a Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonist For Acute Treatment of Migraine. Journal of Medicinal Chemistry. PMID 32558564 DOI: 10.1021/acs.jmedchem.0c01003   
2020 Che C, Zeng Y, Xu Y, Lu H, Xu Y, Zhang X, Xiao Y, Li JQ, Qin Z. APAn, a Class of ABA Receptor Agonism/antagonism Switching Probes. Journal of Agricultural and Food Chemistry. PMID 32687337 DOI: 10.1021/acs.jafc.0c02154   
2020 Krintel C, Dorosz J, Larsen AH, Seneca Thorsen T, Venskutonytė R, Mirza O, Gajhede M, Boesen T, Kastrup JS. Binding of a negative allosteric modulator and competitive antagonist can occur simultaneously at the ionotropic glutamate receptor GluA2. The Febs Journal. PMID 32543078 DOI: 10.1111/febs.15455   
2020 Liu R, Zhang M, Liu L, Chen G, Hou Y, Wang M, Li J. Neuronal Surface Antibody Syndrome: A Review of the Characteristics of the Disease and Its Association with Autoantibodies. Neuroimmunomodulation. 1-8. PMID 32554968 DOI: 10.1159/000507448   
2020 Wu X, Li JY, Lee A, Lu YX, Zhou SY, Owyang C. Satiety induced by bile acids is mediated via vagal afferent pathways. Jci Insight. 5. PMID 32699194 DOI: 10.1172/jci.insight.132400   
2020 Neerukonda N, Bliss M, Jafroodifar A, Leontieva L. Olanzapine and Lorazepam Used in the Symptomatic Management of Excited Catatonia Secondary to Anti-N-Methyl-D-Aspartate Receptor Encephalitis. Cureus. 12: e8689. PMID 32577332 DOI: 10.7759/cureus.8689   
2020 Gharishvandi F, Abdollahi A, Shafaroodi H, Jafari RM, Pasalar P, Dehpour AR. Involvement of 5-HT1B/1D receptors in the inflammatory response and oxidative stress in intestinal ischemia/reperfusion in rats. European Journal of Pharmacology. 173265. PMID 32574671 DOI: 10.1016/j.ejphar.2020.173265   
2020 Zhang X, Meng R, Wang H, Xing J. Differential Effects of Components in Artemisia annua Extract on the Induction of Drug-Metabolizing Enzyme Expression Mediated by Nuclear Receptors. Planta Medica. PMID 32557519 DOI: 10.1055/a-1178-0852   
2020 Liu P, Du J. Oridonin is an antidepressant molecule working through the PPAR-γ/AMPA receptor signaling pathway. Biochemical Pharmacology. 114136. PMID 32628930 DOI: 10.1016/j.bcp.2020.114136   
2020 Sun HS, Yang QR, Bai YY, Hu NW, Liu DX, Qin CY. Gene testing for osteonecrosis of the femoral head in systemic lupus erythematosus using targeted next-generation sequencing: A pilot study. World Journal of Clinical Cases. 8: 2530-2541. PMID 32607330 DOI: 10.12998/wjcc.v8.i12.2530   
2020 Chen YN, Sha HH, Wang YW, Zhou Q, Bhuiyan P, Li NN, Qian YN, Dong HQ. Histamine 2/3 receptor agonists alleviate perioperative neurocognitive disorders by inhibiting microglia activation through the PI3K/AKT/FoxO1 pathway in aged rats. Journal of Neuroinflammation. 17: 217. PMID 32698899 DOI: 10.1186/s12974-020-01886-2   
2020 Di Pasquale A, Tommasone S, Xu L, Ma J, Mendes PM. Cooperative Multipoint Recognition of Sialic Acid by Benzoboroxole-Based Receptors Bearing Cationic Hydrogen-Bond Donors. The Journal of Organic Chemistry. PMID 32508094 DOI: 10.1021/acs.joc.0c00173   
2020 Lesage A, Gibson C, Marceau F, Ambrosi HD, Saupe J, Katzer W, Loenders B, Charest-Morin X, Knolle J. Pharmacological Profile of a New Small Molecule Bradykinin B Receptor Antagonist. Frontiers in Pharmacology. 11: 916. PMID 32636746 DOI: 10.3389/fphar.2020.00916   
2020 Mugnaini C, Kostrzewa M, Bryk M, Mahmoud AM, Brizzi A, Lamponi S, Giorgi G, Ferlenghi F, Vacondio F, Maccioni P, Colombo G, Mor M, Starowicz K, Di Marzo V, Ligresti A, et al. Design, Synthesis, and Physicochemical and Pharmacological Profiling of 7-Hydroxy-5-oxopyrazolo[4,3-]pyridine-6-carboxamide Derivatives with Antiosteoarthritic Activity In Vivo. Journal of Medicinal Chemistry. PMID 32515588 DOI: 10.1021/acs.jmedchem.0c00595   
2020 Friedman S, Tauber M, Ben-Chaim Y. Sodium ions allosterically modulate the M2 muscarinic receptor. Scientific Reports. 10: 11177. PMID 32636499 DOI: 10.1038/s41598-020-68133-9   
2020 Gillet C, Kurth S, Kuenzel T. Muscarinic modulation of M and h currents in gerbil spherical bushy cells. Plos One. 15: e0226954. PMID 31940388 DOI: 10.1371/journal.pone.0226954   
2020 Drimousis S, Markus I, Murphy TV, Perera DS, Phan-Thien KC, Zhang L, Liu L. Gender-related differences of tachykinin NK receptor expression and activity in human colonic smooth muscle. The Journal of Pharmacology and Experimental Therapeutics. PMID 32764152 DOI: 10.1124/jpet.120.265967   
2020 Yuwei W, Dongqin F, Qiaofen G, Li Y, Qian Z, Han J, Liu Z, Ren W, Liu Y. Activation of CB1 receptors on GABAergic interneurons in the ventrolateral orbital cortex induces analgesia. Neuroscience Letters. 135286. PMID 32745558 DOI: 10.1016/j.neulet.2020.135286   
2020 Gutjahr A, Papagno L, Vernejoul F, Lioux T, Jospin F, Chanut B, Perouzel E, Rochereau N, Appay V, Verrier B, Paul S. New chimeric TLR7/NOD2 agonist is a potent adjuvant to induce mucosal immune responses. Ebiomedicine. 58: 102922. PMID 32739871 DOI: 10.1016/j.ebiom.2020.102922   
2020 Gutjahr A, Papagno L, Vernejoul F, Lioux T, Jospin F, Chanut B, Perouzel E, Rochereau N, Appay V, Verrier B, Paul S. New chimeric TLR7/NOD2 agonist is a potent adjuvant to induce mucosal immune responses. Ebiomedicine. 58: 102922. PMID 32739871 DOI: 10.1016/j.ebiom.2020.102922   
2020 Segura-Chama P, Luis E, Almanza A, Pellicer F, Hernández-Cruz A, Mercado F. Modulation of intracellular calcium concentration by D2-like DA receptor agonists in non-peptidergic DRG neurons is mediated mainly by D4 receptor activation. Neuroscience Letters. 135267. PMID 32717335 DOI: 10.1016/j.neulet.2020.135267