| Year |
Citation |
Score |
| 2023 |
Zhang X, Kortholt A. LRRK2 Structure-Based Activation Mechanism and Pathogenesis. Biomolecules. 13. PMID 37189360 DOI: 10.3390/biom13040612 |
0.317 |
|
| 2022 |
Xu X, Pots H, Gilsbach BK, Parsons D, Veltman DM, Ramachandra SG, Li H, Kortholt A, Jin T. C2GAP2 is a common regulator of Ras signaling for chemotaxis, phagocytosis, and macropinocytosis. Frontiers in Immunology. 13: 1075386. PMID 36524124 DOI: 10.3389/fimmu.2022.1075386 |
0.762 |
|
| 2022 |
Oun A, Soliman A, Trombetta-Lima M, Tzepapadaki A, Tsagkari D, Kortholt A, Dolga AM. LRRK2 protects immune cells against erastin-induced ferroptosis. Neurobiology of Disease. 175: 105917. PMID 36336242 DOI: 10.1016/j.nbd.2022.105917 |
0.323 |
|
| 2022 |
Singh RK, Soliman A, Guaitoli G, Störmer E, von Zweydorf F, Dal Maso T, Oun A, Van Rillaer L, Schmidt SH, Chatterjee D, David JA, Pardon E, Schwartz TU, Knapp S, Kennedy EJ, ... ... Kortholt A, et al. Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2. Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 35217606 DOI: 10.1073/pnas.2112712119 |
0.305 |
|
| 2022 |
Cogo S, Ho FY, Tosoni E, Tomkins JE, Tessari I, Iannotta L, Montine TJ, Manzoni C, Lewis PA, Bubacco L, Chartier Harlin MC, Taymans JM, Kortholt A, Nichols J, Cendron L, et al. The Roc domain of LRRK2 as a hub for protein-protein interactions: a focus on PAK6 and its impact on RAB phosphorylation. Brain Research. 147781. PMID 35016853 DOI: 10.1016/j.brainres.2022.147781 |
0.329 |
|
| 2021 |
Xu X, Bhimani S, Pots H, Wen X, Jeon TJ, Kortholt A, Jin T. Membrane Targeting of C2GAP1 Enables to Sense Chemoattractant Gradient at a Higher Concentration Range. Frontiers in Cell and Developmental Biology. 9: 725073. PMID 34395450 DOI: 10.3389/fcell.2021.725073 |
0.314 |
|
| 2021 |
van Haastert PJM, Keizer-Gunnink I, Pots H, Ortiz-Mateos C, Veltman D, van Egmond W, Kortholt A. 45 years of cGMP research in : Understanding the regulation and function of the cGMP pathway for cell movement and chemotaxis. Molecular Biology of the Cell. mbcE21040171. PMID 34347507 DOI: 10.1091/mbc.E21-04-0171 |
0.753 |
|
| 2020 |
Buckley CM, Pots H, Gueho A, Vines JH, Munn CJ, Phillips BA, Gilsbach B, Traynor D, Nikolaev A, Soldati T, Parnell AJ, Kortholt A, King JS. Coordinated Ras and Rac Activity Shapes Macropinocytic Cups and Enables Phagocytosis of Geometrically Diverse Bacteria. Current Biology : Cb. PMID 32531280 DOI: 10.1016/J.Cub.2020.05.049 |
0.526 |
|
| 2020 |
Leemans M, Galicia C, Deyaert E, Daems E, Krause L, Paesmans J, Pardon E, Steyaert J, Kortholt A, Sobott F, Klostermeier D, Versées W. Allosteric modulation of the GTPase activity of a bacterial LRRK2 homologue by conformation-specific Nanobodies. The Biochemical Journal. PMID 32167135 DOI: 10.1042/Bcj20190843 |
0.424 |
|
| 2019 |
Wauters L, Versées W, Kortholt A. Roco Proteins: GTPases with a Baroque Structure and Mechanism. International Journal of Molecular Sciences. 20. PMID 30609797 DOI: 10.3390/Ijms20010147 |
0.436 |
|
| 2018 |
Deyaert E, Leemans M, Singh RK, Gallardo R, Steyaert J, Kortholt A, Lauer J, Versées W. Structure and nucleotide-induced conformational dynamics of the Roco protein. The Biochemical Journal. PMID 30538153 DOI: 10.1042/Bcj20180803 |
0.437 |
|
| 2018 |
Wauters L, Terheyden S, Gilsbach BK, Leemans M, Athanasopoulos PS, Guaitoli G, Wittinghofer A, Gloeckner CJ, Versées W, Kortholt A. Biochemical and kinetic properties of the complex Roco G-protein cycle. Biological Chemistry. PMID 30067506 DOI: 10.1515/Hsz-2018-0227 |
0.479 |
|
| 2018 |
Athanasopoulos PS, Heumann R, Kortholt A. The role of (auto)-phosphorylation in the complex activation mechanism of LRRK2. Biological Chemistry. PMID 29537215 DOI: 10.1515/Hsz-2017-0332 |
0.412 |
|
| 2018 |
van Haastert PJM, Keizer-Gunnink I, Kortholt A. The cytoskeleton regulates symmetry transitions in moving amoeboid cells. Journal of Cell Science. PMID 29487182 DOI: 10.1242/Jcs.208892 |
0.396 |
|
| 2017 |
Xu X, Wen X, Veltman DM, Keizer-Gunnink I, Pots H, Kortholt A, Jin T. GPCR-controlled membrane recruitment of negative regulator C2GAP1 locally inhibits Ras signaling for adaptation and long-range chemotaxis. Proceedings of the National Academy of Sciences of the United States of America. PMID 29109256 DOI: 10.1073/Pnas.1703208114 |
0.771 |
|
| 2017 |
Deyaert E, Wauters L, Guaitoli G, Konijnenberg A, Leemans M, Terheyden S, Petrovic A, Gallardo R, Nederveen-Schippers LM, Athanasopoulos PS, Pots H, Van Haastert PJM, Sobott F, Gloeckner CJ, Efremov R, ... Kortholt A, et al. A homologue of the Parkinson's disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover. Nature Communications. 8: 1008. PMID 29044096 DOI: 10.1038/S41467-017-01103-4 |
0.409 |
|
| 2017 |
Deyaert E, Kortholt A, Versées W. The LRR-Roc-COR module of the Chlorobium tepidum Roco protein: crystallization and X-ray crystallographic analysis. Acta Crystallographica. Section F, Structural Biology Communications. 73: 520-524. PMID 28876231 DOI: 10.1107/S2053230X17011955 |
0.35 |
|
| 2017 |
Hilbi H, Kortholt A. Role of the small GTPase Rap1 in signal transduction, cell dynamics and bacterial infection. Small Gtpases. 1-7. PMID 28632994 DOI: 10.1080/21541248.2017.1331721 |
0.525 |
|
| 2017 |
van Haastert PJ, Keizer-Gunnink I, Kortholt A. Coupled excitable Ras and F-actin activation mediates spontaneous pseudopod formation and directed cell movement. Molecular Biology of the Cell. 28: 922-934. PMID 28148648 DOI: 10.1091/Mbc.E16-10-0733 |
0.698 |
|
| 2016 |
Terheyden S, Nederveen-Schippers LM, Kortholt A. The unconventional G-protein cycle of LRRK2 and Roco proteins. Biochemical Society Transactions. 44: 1611-1616. PMID 27913669 DOI: 10.1042/Bst20160224 |
0.468 |
|
| 2016 |
Liu Y, Lacal J, Firtel RA, Kortholt A. Connecting G protein signaling to chemoattractant-mediated cell polarity and cytoskeletal reorganization. Small Gtpases. 0. PMID 27715492 DOI: 10.1080/21541248.2016.1235390 |
0.494 |
|
| 2016 |
Guaitoli G, Raimondi F, Gilsbach BK, Gómez-Llorente Y, Deyaert E, Renzi F, Li X, Schaffner A, Jagtap PK, Boldt K, von Zweydorf F, Gotthardt K, Lorimer DD, Yue Z, Burgin A, ... ... Kortholt A, et al. Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts. Proceedings of the National Academy of Sciences of the United States of America. PMID 27357661 DOI: 10.1073/Pnas.1523708113 |
0.405 |
|
| 2016 |
Skoge M, Wong E, Hamza B, Bae A, Martel J, Kataria R, Keizer-Gunnink I, Kortholt A, Van Haastert PJ, Charras G, Janetopoulos C, Irimia D. A Worldwide Competition to Compare the Speed and Chemotactic Accuracy of Neutrophil-Like Cells. Plos One. 11: e0154491. PMID 27332963 DOI: 10.1371/Journal.Pone.0154491 |
0.645 |
|
| 2016 |
Rosenbusch KE, Kortholt A. Activation Mechanism of LRRK2 and Its Cellular Functions in Parkinson's Disease. Parkinson's Disease. 2016: 7351985. PMID 27293958 DOI: 10.1155/2016/7351985 |
0.428 |
|
| 2016 |
Liu Y, Lacal J, Veltman DM, Fusetti F, van Haastert PJ, Firtel RA, Kortholt A. A Gα-Stimulated RapGEF Is a Receptor-Proximal Regulator of Dictyostelium Chemotaxis. Developmental Cell. PMID 27237792 DOI: 10.1016/J.Devcel.2016.05.001 |
0.824 |
|
| 2016 |
Khanna A, Lotfi P, Chavan AJ, Montaño NM, Bolourani P, Weeks G, Shen Z, Briggs SP, Pots H, Van Haastert PJ, Kortholt A, Charest PG. The small GTPases Ras and Rap1 bind to and control TORC2 activity. Scientific Reports. 6: 25823. PMID 27172998 DOI: 10.1038/Srep25823 |
0.752 |
|
| 2016 |
Plak K, Pots H, Van Haastert PJ, Kortholt A. Direct Interaction between TalinB and Rap1 is necessary for adhesion of Dictyostelium cells. Bmc Cell Biology. 17: 1. PMID 26744136 DOI: 10.1186/S12860-015-0078-0 |
0.726 |
|
| 2015 |
Kamp ME, Liu Y, Kortholt A. Function and Regulation of Heterotrimeric G Proteins during Chemotaxis. International Journal of Molecular Sciences. 17. PMID 26784171 DOI: 10.3390/Ijms17010090 |
0.486 |
|
| 2015 |
Rudi K, Ho FY, Gilsbach BK, Pots H, Wittinghofer A, Kortholt A, Klare JP. Conformational heterogeneity of the Roc domains in C. tepidum Roc-COR and implications for human LRRK2 Parkinson mutations. Bioscience Reports. 35. PMID 26310572 DOI: 10.1042/Bsr20150128 |
0.448 |
|
| 2015 |
Wu J, Pipathsouk A, Keizer-Gunnink A, Fusetti F, Alkema W, Liu S, Altschuler S, Wu L, Kortholt A, Weiner OD. Homer3 regulates the establishment of neutrophil polarity. Molecular Biology of the Cell. 26: 1629-39. PMID 25739453 DOI: 10.1091/Mbc.E14-07-1197 |
0.502 |
|
| 2015 |
Terheyden S, Ho FY, Gilsbach BK, Wittinghofer A, Kortholt A. Revisiting the Roco G-protein cycle. The Biochemical Journal. 465: 139-47. PMID 25317655 DOI: 10.1042/Bj20141095 |
0.477 |
|
| 2015 |
Wu J, Pipathsouk A, Keizer-Gunnink A, Alkema W, Fusetti F, Liu S, Atschuler S, Wu L, Kortholt A, Weiner O. Abstract B48: Homer3 regulates the establishment of neutrophil polarity Cancer Immunology Research. 3. DOI: 10.1158/2326-6074.Tumimm14-B48 |
0.47 |
|
| 2014 |
Plak K, Keizer-Gunnink I, van Haastert PJ, Kortholt A. Rap1-dependent pathways coordinate cytokinesis in Dictyostelium. Molecular Biology of the Cell. 25: 4195-204. PMID 25298405 DOI: 10.1091/Mbc.E14-08-1285 |
0.72 |
|
| 2014 |
Gilsbach BK, Kortholt A. Structural biology of the LRRK2 GTPase and kinase domains: implications for regulation. Frontiers in Molecular Neuroscience. 7: 32. PMID 24847205 DOI: 10.3389/Fnmol.2014.00032 |
0.459 |
|
| 2013 |
Kataria R, van Haastert PJ, Kortholt A. Reply to Tall et al.: Dictyostelium Ric8 does not have a chaperoning function during development and chemotaxis. Proceedings of the National Academy of Sciences of the United States of America. 110: E3149. PMID 24137657 DOI: 10.1073/Pnas.1309837110 |
0.722 |
|
| 2013 |
Kortholt A, Keizer-Gunnink I, Kataria R, Van Haastert PJ. Ras activation and symmetry breaking during Dictyostelium chemotaxis. Journal of Cell Science. 126: 4502-13. PMID 23886948 DOI: 10.1242/Jcs.132340 |
0.741 |
|
| 2013 |
Kataria R, Xu X, Fusetti F, Keizer-Gunnink I, Jin T, van Haastert PJ, Kortholt A. Dictyostelium Ric8 is a nonreceptor guanine exchange factor for heterotrimeric G proteins and is important for development and chemotaxis. Proceedings of the National Academy of Sciences of the United States of America. 110: 6424-9. PMID 23576747 DOI: 10.1073/Pnas.1301851110 |
0.722 |
|
| 2013 |
Plak K, Veltman D, Fusetti F, Beeksma J, Rivero F, Van Haastert PJ, Kortholt A. GxcC connects Rap and Rac signaling during Dictyostelium development. Bmc Cell Biology. 14: 6. PMID 23363311 DOI: 10.1186/1471-2121-14-6 |
0.812 |
|
| 2013 |
Müller-Taubenberger A, Kortholt A, Eichinger L. Simple system--substantial share: the use of Dictyostelium in cell biology and molecular medicine. European Journal of Cell Biology. 92: 45-53. PMID 23200106 DOI: 10.1016/J.Ejcb.2012.10.003 |
0.347 |
|
| 2013 |
Kölsch V, Shen Z, Lee S, Plak K, Lotfi P, Chang J, Charest PG, Romero JL, Jeon TJ, Kortholt A, Briggs SP, Firtel RA. Daydreamer, a Ras effector and GSK-3 substrate, is important for directional sensing and cell motility. Molecular Biology of the Cell. 24: 100-14. PMID 23135995 DOI: 10.1091/Mbc.E12-04-0271 |
0.587 |
|
| 2012 |
Gilsbach BK, Ho FY, Vetter IR, van Haastert PJ, Wittinghofer A, Kortholt A. Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations. Proceedings of the National Academy of Sciences of the United States of America. 109: 10322-7. PMID 22689969 DOI: 10.1073/Pnas.1203223109 |
0.649 |
|
| 2012 |
Kortholt A, van Egmond WN, Plak K, Bosgraaf L, Keizer-Gunnink I, van Haastert PJ. Multiple regulatory mechanisms for the Dictyostelium Roco protein GbpC. The Journal of Biological Chemistry. 287: 2749-58. PMID 22119747 DOI: 10.1074/Jbc.M111.315739 |
0.819 |
|
| 2011 |
Kortholt A, Kataria R, Keizer-Gunnink I, Van Egmond WN, Khanna A, Van Haastert PJ. Dictyostelium chemotaxis: essential Ras activation and accessory signalling pathways for amplification. Embo Reports. 12: 1273-9. PMID 22081140 DOI: 10.1038/Embor.2011.210 |
0.733 |
|
| 2010 |
Kortholt A, Bolourani P, Rehmann H, Keizer-Gunnink I, Weeks G, Wittinghofer A, Van Haastert PJ. A Rap/phosphatidylinositol 3-kinase pathway controls pseudopod formation [corrected]. Molecular Biology of the Cell. 21: 936-45. PMID 20089846 DOI: 10.1091/Mbc.E09-03-0177 |
0.741 |
|
| 2008 |
van Egmond WN, Kortholt A, Plak K, Bosgraaf L, Bosgraaf S, Keizer-Gunnink I, van Haastert PJ. Intramolecular activation mechanism of the Dictyostelium LRRK2 homolog Roco protein GbpC. The Journal of Biological Chemistry. 283: 30412-20. PMID 18703517 DOI: 10.1074/Jbc.M804265200 |
0.777 |
|
| 2008 |
Gotthardt K, Weyand M, Kortholt A, Van Haastert PJ, Wittinghofer A. Structure of the Roc-COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase. The Embo Journal. 27: 2239-49. PMID 18650931 DOI: 10.1038/Emboj.2008.150 |
0.7 |
|
| 2008 |
Kortholt A, van Haastert PJ. Highlighting the role of Ras and Rap during Dictyostelium chemotaxis. Cellular Signalling. 20: 1415-22. PMID 18385017 DOI: 10.1016/J.Cellsig.2008.02.006 |
0.738 |
|
| 2007 |
Kortholt A, King JS, Keizer-Gunnink I, Harwood AJ, Van Haastert PJ. Phospholipase C regulation of phosphatidylinositol 3,4,5-trisphosphate-mediated chemotaxis. Molecular Biology of the Cell. 18: 4772-9. PMID 17898079 DOI: 10.1091/Mbc.E07-05-0407 |
0.69 |
|
| 2007 |
van Haastert PJ, Keizer-Gunnink I, Kortholt A. Essential role of PI3-kinase and phospholipase A2 in Dictyostelium discoideum chemotaxis. The Journal of Cell Biology. 177: 809-16. PMID 17535967 DOI: 10.1083/Jcb.200701134 |
0.68 |
|
| 2007 |
Keizer-Gunnink I, Kortholt A, Van Haastert PJ. Chemoattractants and chemorepellents act by inducing opposite polarity in phospholipase C and PI3-kinase signaling. The Journal of Cell Biology. 177: 579-85. PMID 17517960 DOI: 10.1083/Jcb.200611046 |
0.692 |
|
| 2007 |
Kae H, Kortholt A, Rehmann H, Insall RH, Van Haastert PJ, Spiegelman GB, Weeks G. Cyclic AMP signalling in Dictyostelium: G-proteins activate separate Ras pathways using specific RasGEFs. Embo Reports. 8: 477-82. PMID 17380187 DOI: 10.1038/Sj.Embor.7400936 |
0.734 |
|
| 2007 |
Loovers HM, Kortholt A, de Groote H, Whitty L, Nussbaum RL, van Haastert PJM. Regulation of phagocytosis in Dictyostelium by the inositol 5-phosphatase OCRL homolog Dd5P4 Traffic. 8: 618-628. PMID 17343681 DOI: 10.1111/J.1600-0854.2007.00546.X |
0.771 |
|
| 2007 |
Bader S, Kortholt A, Van Haastert PJ. Seven Dictyostelium discoideum phosphodiesterases degrade three pools of cAMP and cGMP. The Biochemical Journal. 402: 153-61. PMID 17040207 DOI: 10.1042/Bj20061153 |
0.632 |
|
| 2006 |
Kortholt A, Rehmann H, Kae H, Bosgraaf L, Keizer-Gunnink I, Weeks G, Wittinghofer A, Van Haastert PJ. Characterization of the GbpD-activated Rap1 pathway regulating adhesion and cell polarity in Dictyostelium discoideum. The Journal of Biological Chemistry. 281: 23367-76. PMID 16769729 DOI: 10.1074/Jbc.M600804200 |
0.816 |
|
| 2006 |
Bader S, Kortholt A, Snippe H, Van Haastert PJ. DdPDE4, a novel cAMP-specific phosphodiesterase at the surface of dictyostelium cells. The Journal of Biological Chemistry. 281: 20018-26. PMID 16644729 DOI: 10.1074/Jbc.M600040200 |
0.68 |
|
| 2003 |
Blaauw M, Knol JC, Kortholt A, Roelofs J, Ruchira, Postma M, Visser AJ, van Haastert PJ. Phosducin-like proteins in Dictyostelium discoideum: implications for the phosducin family of proteins. The Embo Journal. 22: 5047-57. PMID 14517243 DOI: 10.1093/Emboj/Cdg508 |
0.788 |
|
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