Stephen V Frye - Publications

Affiliations: 
UNC Eshelman School of Pharmacy University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Drug Discovery
Website:
https://pharmacy.unc.edu/news/directory/svfrye/

49 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Müller S, Ackloo S, Arrowsmith CH, Bauser M, Baryza JL, Blagg J, Böttcher J, Bountra C, Brown PJ, Bunnage ME, Carter AJ, Damerell D, Dötsch V, Drewry DH, Edwards AM, ... ... Frye SV, et al. Donated chemical probes for open science. Elife. 7. PMID 29676732 DOI: 10.7554/eLife.34311  1
2016 Zhou H, Che X, Bao G, Wang N, Peng L, Barnash KD, Frye SV, James LI, Bai X. Design, synthesis, and protein methyltransferase activity of a unique set of constrained amine containing compounds. Bioorganic & Medicinal Chemistry Letters. PMID 27528434 DOI: 10.1016/j.bmcl.2016.08.004  1
2016 Frye SV, Jin J. Novel Therapeutics Targeting Epigenetics: New Molecules, New Methods. Acs Medicinal Chemistry Letters. 7: 123. PMID 26985299 DOI: 10.1021/acsmedchemlett.6b00037  1
2016 Pattenden SG, Simon JM, Wali A, Jayakody CN, Troutman J, McFadden AW, Wooten J, Wood CC, Frye SV, Janzen WP, Davis IJ. High-throughput small molecule screen identifies inhibitors of aberrant chromatin accessibility. Proceedings of the National Academy of Sciences of the United States of America. PMID 26929321 DOI: 10.1073/pnas.1521827113  1
2016 Stuckey JI, Dickson BM, Cheng N, Liu Y, Norris JL, Cholensky SH, Tempel W, Qin S, Huber KG, Sagum C, Black K, Li F, Huang XP, Roth BL, Baughman BM, ... ... Frye SV, et al. A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1. Nature Chemical Biology. PMID 26807715 DOI: 10.1038/nchembio.2007  1
2015 Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, ... ... Frye SV, et al. Corrigendum: The promise and peril of chemical probes. Nature Chemical Biology. 11: 887. PMID 26485080 DOI: 10.1038/nchembio1115-887c  1
2015 Frye SV, Arkin MR, Arrowsmith CH, Conn PJ, Glicksman MA, Hull-Ryde EA, Slusher BS. Tackling reproducibility in academic preclinical drug discovery. Nature Reviews. Drug Discovery. 14: 733-4. PMID 26388229 DOI: 10.1038/nrd4737  1
2015 Wallace BD, Roberts AB, Pollet RM, Ingle JD, Biernat KA, Pellock SJ, Venkatesh MK, Guthrie L, O'Neal SK, Robinson SJ, Dollinger M, Figueroa E, McShane SR, Cohen RD, Jin J, ... Frye SV, et al. Structure and Inhibition of Microbiome β-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity. Chemistry & Biology. 22: 1238-49. PMID 26364932 DOI: 10.1016/j.chembiol.2015.08.005  1
2015 Baughman BM, Pattenden SG, Norris JL, James LI, Frye SV. The L3MBTL3 Methyl-Lysine Reader Domain Functions As a Dimer. Acs Chemical Biology. PMID 26317848 DOI: 10.1021/acschembio.5b00632  1
2015 Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, ... ... Frye SV, et al. The promise and peril of chemical probes. Nature Chemical Biology. 11: 536-41. PMID 26196764 DOI: 10.1038/nchembio.1867  1
2015 Cummings CT, Zhang W, Davies KD, Kirkpatrick GD, Zhang D, DeRyckere D, Wang X, Frye SV, Earp HS, Graham DK. Small molecule inhibition of MERTK is efficacious in non-small cell lung cancer models independent of driver oncogene status. Molecular Cancer Therapeutics. PMID 26162689 DOI: 10.1158/1535-7163.MCT-15-0116  1
2015 Xiao L, Kim DJ, Davis CL, McCann JV, Dunleavey JM, Vanderlinden AK, Xu N, Pattenden SG, Frye SV, Xu X, Onaitis M, Monaghan-Benson E, Burridge K, Dudley AC. Tumor Endothelial Cells with Distinct Patterns of TGFβ-Driven Endothelial-to-Mesenchymal Transition. Cancer Research. 75: 1244-54. PMID 25634211 DOI: 10.1158/0008-5472.CAN-14-1616  1
2015 Perfetti MT, Baughman BM, Dickson BM, Mu Y, Cui G, Mader P, Dong A, Norris JL, Rothbart SB, Strahl BD, Brown PJ, Janzen WP, Arrowsmith CH, Mer G, McBride KM, ... ... Frye SV, et al. Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1. Acs Chemical Biology. 10: 1072-81. PMID 25590533 DOI: 10.1021/cb500956g  1
2015 Xu B, On DM, Ma A, Parton T, Konze KD, Pattenden SG, Allison DF, Cai L, Rockowitz S, Liu S, Liu Y, Li F, Vedadi M, Frye SV, Garcia BA, et al. Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia. Blood. 125: 346-57. PMID 25395428 DOI: 10.1182/blood-2014-06-581082  1
2014 Zhang W, DeRyckere D, Hunter D, Liu J, Stashko MA, Minson KA, Cummings CT, Lee M, Glaros TG, Newton DL, Sather S, Zhang D, Kireev D, Janzen WP, Earp HS, ... ... Frye SV, et al. UNC2025, a potent and orally bioavailable MER/FLT3 dual inhibitor. Journal of Medicinal Chemistry. 57: 7031-41. PMID 25068800 DOI: 10.1021/jm500749d  1
2014 Ma A, Yu W, Li F, Bleich RM, Herold JM, Butler KV, Norris JL, Korboukh V, Tripathy A, Janzen WP, Arrowsmith CH, Frye SV, Vedadi M, Brown PJ, Jin J. Discovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8. Journal of Medicinal Chemistry. 57: 6822-33. PMID 25032507 DOI: 10.1021/jm500871s  1
2014 Wright BD, Loo L, Street SE, Ma A, Taylor-Blake B, Stashko MA, Jin J, Janzen WP, Frye SV, Zylka MJ. The lipid kinase PIP5K1C regulates pain signaling and sensitization. Neuron. 82: 836-47. PMID 24853942 DOI: 10.1016/j.neuron.2014.04.006  1
2013 Camerino MA, Zhong N, Dong A, Dickson BM, James LI, Baughman BM, Norris JL, Kireev DB, Janzen WP, Arrowsmith CH, Frye SV. The structure-activity relationships of L3MBTL3 inhibitors: flexibility of the dimer interface. Medchemcomm. 4: 1501-1507. PMID 24466405 DOI: 10.1039/C3MD00197K  1
2013 Zhang W, McIver AL, Stashko MA, DeRyckere D, Branchford BR, Hunter D, Kireev D, Miley MJ, Norris-Drouin J, Stewart WM, Lee M, Sather S, Zhou Y, Di Paola JA, Machius M, ... ... Frye SV, et al. Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. Journal of Medicinal Chemistry. 56: 9693-700. PMID 24219778 DOI: 10.1021/jm4013888  1
2013 Zhang W, Zhang D, Stashko MA, DeRyckere D, Hunter D, Kireev D, Miley MJ, Cummings C, Lee M, Norris-Drouin J, Stewart WM, Sather S, Zhou Y, Kirkpatrick G, Machius M, ... ... Frye SV, et al. Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors. Journal of Medicinal Chemistry. 56: 9683-92. PMID 24195762 DOI: 10.1021/jm401387j  1
2013 Liu F, Barsyte-Lovejoy D, Li F, Xiong Y, Korboukh V, Huang XP, Allali-Hassani A, Janzen WP, Roth BL, Frye SV, Arrowsmith CH, Brown PJ, Vedadi M, Jin J. Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP. Journal of Medicinal Chemistry. 56: 8931-42. PMID 24102134 DOI: 10.1021/jm401480r  1
2013 James LI, Korboukh VK, Krichevsky L, Baughman BM, Herold JM, Norris JL, Jin J, Kireev DB, Janzen WP, Arrowsmith CH, Frye SV. Small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for L3MBTL3. Journal of Medicinal Chemistry. 56: 7358-71. PMID 24040942 DOI: 10.1021/jm400919p  1
2013 Christoph S, Deryckere D, Schlegel J, Frazer JK, Batchelor LA, Trakhimets AY, Sather S, Hunter DM, Cummings CT, Liu J, Yang C, Kireev D, Simpson C, Norris-Drouin J, Hull-Ryde EA, ... ... Frye SV, et al. UNC569, a novel small-molecule mer inhibitor with efficacy against acute lymphoblastic leukemia in vitro and in vivo. Molecular Cancer Therapeutics. 12: 2367-77. PMID 23997116 DOI: 10.1158/1535-7163.MCT-13-0040  1
2013 Cooper MJ, Cox NJ, Zimmerman EI, Dewar BJ, Duncan JS, Whittle MC, Nguyen TA, Jones LS, Ghose Roy S, Smalley DM, Kuan PF, Richards KL, Christopherson RI, Jin J, Frye SV, et al. Application of multiplexed kinase inhibitor beads to study kinome adaptations in drug-resistant leukemia. Plos One. 8: e66755. PMID 23826126 DOI: 10.1371/journal.pone.0066755  1
2013 Liu J, Zhang W, Stashko MA, Deryckere D, Cummings CT, Hunter D, Yang C, Jayakody CN, Cheng N, Simpson C, Norris-Drouin J, Sather S, Kireev D, Janzen WP, Earp HS, ... ... Frye SV, et al. UNC1062, a new and potent Mer inhibitor. European Journal of Medicinal Chemistry. 65: 83-93. PMID 23693152 DOI: 10.1016/j.ejmech.2013.03.035  1
2013 Konze KD, Ma A, Li F, Barsyte-Lovejoy D, Parton T, Macnevin CJ, Liu F, Gao C, Huang XP, Kuznetsova E, Rougie M, Jiang A, Pattenden SG, Norris JL, James LI, ... ... Frye SV, et al. An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1. Acs Chemical Biology. 8: 1324-34. PMID 23614352 DOI: 10.1021/cb400133j  1
2013 Schlegel J, Sambade MJ, Sather S, Moschos SJ, Tan AC, Winges A, DeRyckere D, Carson CC, Trembath DG, Tentler JJ, Eckhardt SG, Kuan PF, Hamilton RL, Duncan LM, Miller CR, ... ... Frye SV, et al. MERTK receptor tyrosine kinase is a therapeutic target in melanoma. The Journal of Clinical Investigation. 123: 2257-67. PMID 23585477 DOI: 10.1172/JCI67816  1
2013 Liu F, Li F, Ma A, Dobrovetsky E, Dong A, Gao C, Korboukh I, Liu J, Smil D, Brown PJ, Frye SV, Arrowsmith CH, Schapira M, Vedadi M, Jin J. Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors. Journal of Medicinal Chemistry. 56: 2110-24. PMID 23445220 DOI: 10.1021/jm3018332  1
2013 James LI, Barsyte-Lovejoy D, Zhong N, Krichevsky L, Korboukh VK, Herold JM, MacNevin CJ, Norris JL, Sagum CA, Tempel W, Marcon E, Guo H, Gao C, Huang XP, Duan S, ... ... Frye SV, et al. Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nature Chemical Biology. 9: 184-91. PMID 23292653 DOI: 10.1038/nchembio.1157  1
2012 Chen X, Sassano MF, Zheng L, Setola V, Chen M, Bai X, Frye SV, Wetsel WC, Roth BL, Jin J. Structure-functional selectivity relationship studies of β-arrestin-biased dopamine Dâ‚‚ receptor agonists. Journal of Medicinal Chemistry. 55: 7141-53. PMID 22845053 DOI: 10.1021/jm300603y  1
2012 Korboukh I, Hull-Ryde EA, Rittiner JE, Randhawa AS, Coleman J, Fitzpatrick BJ, Setola V, Janzen WP, Frye SV, Zylka MJ, Jin J. Orally active adenosine A(1) receptor agonists with antinociceptive effects in mice. Journal of Medicinal Chemistry. 55: 6467-77. PMID 22738238 DOI: 10.1021/jm3004834  1
2012 Liu J, Yang C, Simpson C, Deryckere D, Van Deusen A, Miley MJ, Kireev D, Norris-Drouin J, Sather S, Hunter D, Korboukh VK, Patel HS, Janzen WP, Machius M, Johnson GL, ... ... Frye SV, et al. Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia. Acs Medicinal Chemistry Letters. 3: 129-134. PMID 22662287  1
2012 Duncan JS, Whittle MC, Nakamura K, Abell AN, Midland AA, Zawistowski JS, Johnson NL, Granger DA, Jordan NV, Darr DB, Usary J, Kuan PF, Smalley DM, Major B, He X, ... ... Frye SV, et al. Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer. Cell. 149: 307-21. PMID 22500798 DOI: 10.1016/j.cell.2012.02.053  1
2012 Rittiner JE, Korboukh I, Hull-Ryde EA, Jin J, Janzen WP, Frye SV, Zylka MJ. AMP is an adenosine A1 receptor agonist. The Journal of Biological Chemistry. 287: 5301-9. PMID 22215671 DOI: 10.1074/jbc.M111.291666  1
2011 Herold JM, Ingerman LA, Gao C, Frye SV. Drug discovery toward antagonists of methyl-lysine binding proteins. Current Chemical Genomics. 5: 51-61. PMID 22145013 DOI: 10.2174/1875397301005010051  1
2011 Allen JA, Yost JM, Setola V, Chen X, Sassano MF, Chen M, Peterson S, Yadav PN, Huang XP, Feng B, Jensen NH, Che X, Bai X, Frye SV, Wetsel WC, et al. Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy. Proceedings of the National Academy of Sciences of the United States of America. 108: 18488-93. PMID 22025698 DOI: 10.1073/pnas.1104807108  1
2011 Liu F, Barsyte-Lovejoy D, Allali-Hassani A, He Y, Herold JM, Chen X, Yates CM, Frye SV, Brown PJ, Huang J, Vedadi M, Arrowsmith CH, Jin J. Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines. Journal of Medicinal Chemistry. 54: 6139-50. PMID 21780790 DOI: 10.1021/jm200903z  1
2011 Vedadi M, Barsyte-Lovejoy D, Liu F, Rival-Gervier S, Allali-Hassani A, Labrie V, Wigle TJ, Dimaggio PA, Wasney GA, Siarheyeva A, Dong A, Tempel W, Wang SC, Chen X, Chau I, ... ... Frye SV, et al. A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nature Chemical Biology. 7: 566-74. PMID 21743462 DOI: 10.1038/nchembio.599  1
2011 Herold JM, Wigle TJ, Norris JL, Lam R, Korboukh VK, Gao C, Ingerman LA, Kireev DB, Senisterra G, Vedadi M, Tripathy A, Brown PJ, Arrowsmith CH, Jin J, Janzen WP, ... Frye SV, et al. Small-molecule ligands of methyl-lysine binding proteins. Journal of Medicinal Chemistry. 54: 2504-11. PMID 21417280 DOI: 10.1021/jm200045v  1
2011 Edwards AM, Isserlin R, Bader GD, Frye SV, Willson TM, Yu FH. Too many roads not taken. Nature. 470: 163-5. PMID 21307913 DOI: 10.1038/470163a  1
2010 Janzen WP, Wigle TJ, Jin J, Frye SV. Epigenetics: Tools and Technologies. Drug Discovery Today. Technologies. 7: e59-e65. PMID 21243036 DOI: 10.1016/j.ddtec.2010.07.004  0.01
2010 Kireev D, Wigle TJ, Norris-Drouin J, Herold JM, Janzen WP, Frye SV. Identification of non-peptide malignant brain tumor (MBT) repeat antagonists by virtual screening of commercially available compounds. Journal of Medicinal Chemistry. 53: 7625-31. PMID 20931980 DOI: 10.1021/jm1007374  1
2010 Wigle TJ, Provencher LM, Norris JL, Jin J, Brown PJ, Frye SV, Janzen WP. Accessing protein methyltransferase and demethylase enzymology using microfluidic capillary electrophoresis. Chemistry & Biology. 17: 695-704. PMID 20659682 DOI: 10.1016/j.chembiol.2010.04.014  1
2010 Liu F, Chen X, Allali-Hassani A, Quinn AM, Wigle TJ, Wasney GA, Dong A, Senisterra G, Chau I, Siarheyeva A, Norris JL, Kireev DB, Jadhav A, Herold JM, Janzen WP, ... ... Frye SV, et al. Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines. Journal of Medicinal Chemistry. 53: 5844-57. PMID 20614940 DOI: 10.1021/jm100478y  1
2010 Frye SV. The art of the chemical probe. Nature Chemical Biology. 6: 159-161. PMID 20154659 DOI: 10.1038/nchembio.296  0.01
2010 Wigle TJ, Herold JM, Senisterra GA, Vedadi M, Kireev DB, Arrowsmith CH, Frye SV, Janzen WP. Screening for inhibitors of low-affinity epigenetic peptide-protein interactions: an AlphaScreen-based assay for antagonists of methyl-lysine binding proteins. Journal of Biomolecular Screening. 15: 62-71. PMID 20008125 DOI: 10.1177/1087057109352902  1
2009 Liu F, Chen X, Allali-Hassani A, Quinn AM, Wasney GA, Dong A, Barsyte D, Kozieradzki I, Senisterra G, Chau I, Siarheyeva A, Kireev DB, Jadhav A, Herold JM, Frye SV, et al. Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a. Journal of Medicinal Chemistry. 52: 7950-3. PMID 19891491 DOI: 10.1021/jm901543m  1
2009 Frye SV, Johnson GL. Inhibitors paradoxically prime kinases. Nature Chemical Biology. 5: 448-9. PMID 19465930 DOI: 10.1038/nchembio.f.11  1
2002 Davis ST, Benson BG, Bramson HN, Chapman DE, Dickerson SH, Dold KM, Eberwein DJ, Edelstein M, Frye SV, Gampe RT, Grifffen RJ, Harris PA, Hassell AM, Holmes WD, Hunter RN, et al. Retraction. Science (New York, N.Y.). 298: 2327. PMID 12526115  1
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