David O'Hagan - Publications

Affiliations: 
Chemistry School of Chemistry, University of At Andrews 

197 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 O'Hagan D, Clark J, Neyyappadath RM, Yu C, Slawin AMZ, Cordes DB. Janus all-cis 2,3,4,5,6-pentafluorocyclohexyl building blocks applied to medicinal chemistry and bioactives discovery chemistry'. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 34486192 DOI: 10.1002/chem.202102819  1
2021 Clark JL, Taylor A, Geddis A, Neyyappadath RM, Piscelli BA, Yu C, Cordes DB, Slawin AMZ, Cormanich RA, Guldin S, O'Hagan D. Supramolecular packing of alkyl substituted Janus face all- 2,3,4,5,6-pentafluorocyclohexyl motifs. Chemical Science. 12: 9712-9719. PMID 34349942 DOI: 10.1039/d1sc02130c  1
2021 Joshi PU, Turpeinen DG, Schroeder M, Jones B, Lyons A, Kriz S, Khaksari M, O'Hagan D, Nikam S, Heldt CL. Osmolyte enhanced aqueous two-phase system for virus purification. Biotechnology and Bioengineering. PMID 34129733 DOI: 10.1002/bit.27849  0.01
2021 O'Hagan D. Organo-fluorine chemistry V. Beilstein Journal of Organic Chemistry. 17: 737-738. PMID 33796161 DOI: 10.3762/bjoc.17.63  0.01
2021 Piscelli BA, O'Hagan D, Cormanich RA. The contribution of non-classical CHOC hydrogen bonds to the anomeric effect in fluoro and oxa-methoxycyclohexanes. Physical Chemistry Chemical Physics : Pccp. PMID 33688868 DOI: 10.1039/d0cp06646j  1
2020 Calero P, Volke DC, Lowe PT, Gotfredsen CH, O'Hagan D, Nikel PI. A fluoride-responsive genetic circuit enables in vivo biofluorination in engineered Pseudomonas putida. Nature Communications. 11: 5045. PMID 33028813 DOI: 10.1038/s41467-020-18813-x  1
2020 O'Hagan D, Yu C, Kütt A, Röschenthaler GV, Lebl T, Cordes DB, Slawin AMZ, Bűhl M. Janus face all-cis 1,2,4,5-tetrakis(trifluoromethyl)- and all-cis 1,2,3,4,5,6-hexakis(trifluoromethyl)- cyclohexanes. Angewandte Chemie (International Ed. in English). PMID 32691941 DOI: 10.1002/Anie.202008662  1
2020 Piscelli BA, Sanders W, Yu C, Al Maharik N, Lebl T, Cormanisch RA, O'Hagan D. Fluorine induced pseudo-anomeric effects in methoxycyclohexanes through electrostatic 1,3-diaxial interactions. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 32588927 DOI: 10.1002/Chem.202003058  1
2020 Fang Z, Al-Maharik N, Kirsch P, Bremer M, Slawin AMZ, O'Hagan D. Synthesis of organic liquid crystals containing selectively fluorinated cyclopropanes. Beilstein Journal of Organic Chemistry. 16: 674-680. PMID 32362945 DOI: 10.3762/Bjoc.16.65  1
2020 O'Hagan D. Polar organofluorine substituents: Multivicinal fluorines on alkyl chains and alicyclic rings. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 32083392 DOI: 10.1002/Chem.202000178  0.01
2020 Markakis KI, Lowe PT, Davison-Gates L, O'Hagan D, Rosser SJ, Elfick A. An engineered E. coli strain for direct in vivo fluorination. Chembiochem : a European Journal of Chemical Biology. PMID 32003116 DOI: 10.1002/cbic.202000051  1
2020 Al-Maharik N, Cordes DB, Slawin AMZ, Bühl M, O'Hagan D. Probing the helical integrity of multivicinal all-syn-fluoro alkanes. Organic & Biomolecular Chemistry. PMID 31942902 DOI: 10.1039/C9Ob02647A  1
2020 O'Hagan D. Frontispiece: Polar Organofluorine Substituents: Multivicinal Fluorines on Alkyl Chains and Alicyclic Rings Chemistry: a European Journal. 26. DOI: 10.1002/Chem.202083662  0.01
2019 Feng X, Bello D, Lowe PT, Clark J, O'Hagan D. Two 3'--β-glucosylated nucleoside fluorometabolites related to nucleocidin in . Chemical Science. 10: 9501-9505. PMID 32110306 DOI: 10.1039/C9Sc03374B  1
2019 Fang Z, Gillatt RZ, Slawin AMZ, Cordes DB, Carpenter-Warren CL, O'Hagan D. Unexpected α,α'-difluoroethers from Ag(i)F and N-bromosuccinimide reactions of dibenzo[a,e]cyclooctatetraene. Chemical Communications (Cambridge, England). PMID 31712787 DOI: 10.1039/C9Cc06426E  1
2019 Fang Z, Cordes DB, Slawin AMZ, O'Hagan D. Fluorine containing cyclopropanes: synthesis of aryl substituted all-cis 1,2,3-trifluorocyclopropanes, a facially polar motif. Chemical Communications (Cambridge, England). PMID 31414105 DOI: 10.1039/C9Cc05749H  1
2019 Lowe PT, Cobb SL, O'Hagan D. An enzymatic Finkelstein reaction: fluorinase catalyses direct halogen exchange. Organic & Biomolecular Chemistry. PMID 31364664 DOI: 10.1039/C9Ob01625B  1
2019 Rodil A, Slawin AMZ, Al-Maharik N, Tomita R, O'Hagan D. Fluorine-containing substituents: metabolism of the α,α-difluoroethyl thioether motif. Beilstein Journal of Organic Chemistry. 15: 1441-1447. PMID 31293694 DOI: 10.3762/bjoc.15.144  1
2019 Lowe PT, Dall'Angelo S, Fleming IN, Piras M, Zanda M, O'Hagan D. Enzymatic radiosynthesis of a F-Glu-Ureido-Lys ligand for the prostate-specific membrane antigen (PSMA). Organic & Biomolecular Chemistry. 17: 1480-1486. PMID 30681115 DOI: 10.1039/C8Ob03150A  1
2019 O'Hagan D, Bello D, Rubanu MG, Bandaranayaka N, Götze JP, Bühl M. Acetyl coenzyme A analogues as rationally designed inhibitors of citrate synthase. Chembiochem : a European Journal of Chemical Biology. PMID 30605257 DOI: 10.1002/Cbic.201800700  1
2018 Thomson CJ, Zhang Q, Al-Maharik N, Bühl M, Cordes DB, Slawin AMZ, O'Hagan D. Fluorinated cyclopropanes: synthesis and chemistry of the aryl α,β,β-trifluorocyclopropane motif. Chemical Communications (Cambridge, England). PMID 29999054 DOI: 10.1039/c8cc04964e  1
2018 Lowe PT, Dall'Angelo S, Devine A, Zanda M, O'Hagan D. Enzymatic fluorination of biotin and tetrazine conjugates for pre-targeting approaches to PET imaging. Chembiochem : a European Journal of Chemical Biology. PMID 29966048 DOI: 10.1002/Cbic.201800234  1
2018 O'Hagan D, Bykova T, Slawin A, Buehl M, Lebl T, Al-Maharik N. Benzylic functionalisation of phenyl all cis-2, 3, 5, 6 -tetrafluoro -cyclohexane provides access to new organo-fluorine building blocks. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29882357 DOI: 10.1002/Chem.201802166  1
2018 Rodil A, Bosisio S, Ayoup MS, Quinn L, Cordes DB, Slawin AMZ, Murphy CD, Michel J, O'Hagan D. Metabolism and hydrophilicity of the polarised 'Janus face' all- tetrafluorocyclohexyl ring, a candidate motif for drug discovery. Chemical Science. 9: 3023-3028. PMID 29732086 DOI: 10.1039/C8Sc00299A  1
2018 Ahmed L, Zhang Y, Block E, Buehl M, Corr MJ, Cormanich RA, Gundala S, Matsunami H, O'Hagan D, Ozbil M, Pan Y, Sekharan S, Ten N, Wang M, Yang M, et al. Molecular mechanism of activation of human musk receptors OR5AN1 and OR1A1 by ()-muscone and diverse other musk-smelling compounds. Proceedings of the National Academy of Sciences of the United States of America. PMID 29632183 DOI: 10.1073/Pnas.1713026115  1
2018 Keddie NS, Champagne PA, Desroches J, Paquin JF, O'Hagan D. Stereochemical outcomes of C-F activation reactions of benzyl fluoride. Beilstein Journal of Organic Chemistry. 14: 106-113. PMID 29441134 DOI: 10.3762/Bjoc.14.6  1
2018 Tomita R, Al-Maharik N, Rodil A, Bühl M, O'Hagan D. Synthesis of aryl α,α-difluoroethyl thioethers a novel structure motif in organic chemistry, and extending to aryl α,α-difluoro oxyethers. Organic & Biomolecular Chemistry. PMID 29359220 DOI: 10.1039/C7Ob02987J  1
2017 Feng X, Al Maharik N, Bartholomé A, Janso JE, Reilly U, O'Hagan D. Incorporation of [(2)H1]-(1R,2R)- and [(2)H1]-(1S,2R)-glycerols into the antibiotic nucleocidin in Streptomyces calvus. Organic & Biomolecular Chemistry. PMID 28920128 DOI: 10.1039/C7Ob02163A  1
2017 Lowe PT, Dall'Angelo S, Mulder-Krieger T, IJzerman AP, Zanda M, O'Hagan D. A New Class of Fluorinated A2A Adenosine Receptor Agonist with Application to Last-Step Enzymatic [(18) F]Fluorination for PET Imaging. Chembiochem : a European Journal of Chemical Biology. 18: 2156-2164. PMID 28851015 DOI: 10.1002/Cbic.201700382  1
2017 O'Hagan D, Manan MAFA, Cordes D, Slawin A, Liao V, CHua H, Chebib M, Buehl M. The synthesis and evaluation of fluoro-, trifluoromethyl, and iodo- muscimols as GABA agonists. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 28598039 DOI: 10.1002/Chem.201701443  1
2017 Cormanich RA, O'Hagan D, Bühl M. Hyperconjugation is the Source of Helicity in Perfluorinated n-Alkanes. Angewandte Chemie (International Ed. in English). PMID 28561937 DOI: 10.1002/Anie.201704112  1
2017 Bykova T, Al-Maharik N, Slawin AMZ, O'Hagan D. Fluorinated cyclohexanes: Synthesis of amine building blocks of the all-cis 2,3,5,6-tetrafluorocyclohexylamine motif. Beilstein Journal of Organic Chemistry. 13: 728-733. PMID 28503208 DOI: 10.3762/Bjoc.13.72  1
2017 Warner EF, Smith MJ, Zhang Q, Raheem KS, O'Hagan D, O'Connell MA, Kay CD. Signatures of anthocyanin metabolites identified in humans inhibit biomarkers of vascular inflammation in human endothelial cells. Molecular Nutrition & Food Research. PMID 28457017 DOI: 10.1002/Mnfr.201700053  1
2016 Jones MJ, Callejo R, Slawin AM, Bühl M, O'Hagan D. Organofluorine chemistry: Difluoromethylene motifs spaced 1,3 to each other imparts facial polarity to a cyclohexane ring. Beilstein Journal of Organic Chemistry. 12: 2823-2827. PMID 28144355 DOI: 10.3762/Bjoc.12.281  1
2016 Lecours MJ, Marta RA, Steinmetz V, Keddie N, Fillion E, O'Hagan D, McMahon TB, Hopkins WS. Interaction of B12F12(2-) with All-cis 1,2,3,4,5,6 Hexafluorocyclohexane in the Gas Phase. The Journal of Physical Chemistry Letters. 109-113. PMID 27966976 DOI: 10.1021/Acs.Jpclett.6B02629  1
2016 Bartholomé A, Janso JE, Reilly U, O'Hagan D. Fluorometabolite biosynthesis: isotopically labelled glycerol incorporations into the antibiotic nucleocidin in Streptomyces calvus. Organic & Biomolecular Chemistry. PMID 27845468 DOI: 10.1039/C6Ob02291J  1
2016 Al-Maharik N, Kirsch P, Slawin AM, Cordes DB, O'Hagan D. Fluorinated liquid crystals: evaluation of selectively fluorinated facially polarised cyclohexyl motifs for liquid crystal applications. Organic & Biomolecular Chemistry. PMID 27722421 DOI: 10.1039/C6Ob01986B  1
2016 Zhang Q, Dall'Angelo S, Fleming IN, Schweiger LF, Zanda M, O'Hagan D. Last-Step Enzymatic [(18) F]-Fluorination of Cysteine-Tethered RGD Peptides using Modified Barbas Linkers. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27374143 DOI: 10.1002/chem.201601361  1
2016 Callejo R, Corr MJ, Yang M, Wang M, Cordes DB, Slawin AM, O'Hagan D. Fluorinated Musk Fragrances: The CF2 Group as a Conformational Bias Influencing the Odour of Civetone and (R)-Muscone. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27149882 DOI: 10.1002/Chem.201600519  1
2016 Ziegler BE, Lecours MJ, Marta RA, Featherstone J, Fillion E, Hopkins WS, Steinmetz V, Keddie NS, O'Hagan D, McMahon TB. Janus Face Aspect of All-cis 1,2,3,4,5,6-Hexafluorocyclohexane Dictates Remarkable Anion and Cation Interactions In the Gas Phase. Journal of the American Chemical Society. PMID 27149387 DOI: 10.1021/Jacs.6B02856  1
2016 Fang Z, Al-Maharik N, Slawin AM, Bühl M, O'Hagan D. Polar alicyclic rings: synthesis and structure of all cis-1,2,3,4-tetrafluorocyclopentane. Chemical Communications (Cambridge, England). PMID 26996764 DOI: 10.1039/C6Cc01348A  1
2016 Thompson S, Fleming IN, O'Hagan D. Enzymatic transhalogenation of dendritic RGD peptide constructs with the fluorinase. Organic & Biomolecular Chemistry. PMID 26906931 DOI: 10.1039/C6Ob00239K  1
2016 O'Hagan D, Young RJ. Accurate Lipophilicity (log P) Measurements Inform on Subtle Stereoelectronic Effects in Fluorine Chemistry. Angewandte Chemie (International Ed. in English). 55: 3858-60. PMID 26894548 DOI: 10.1002/Anie.201511055  1
2016 Warner EF, Zhang Q, Raheem KS, O'Hagan D, O'Connell MA, Kay CD. Common Phenolic Metabolites of Flavonoids, but Not Their Unmetabolized Precursors, Reduce the Secretion of Vascular Cellular Adhesion Molecules by Human Endothelial Cells. The Journal of Nutrition. PMID 26843586 DOI: 10.3945/jn.115.217943  1
2016 Bykova T, Al-Maharik N, Slawin AM, O'Hagan D. Multicomponent reactions of methyl substituted all-cis tetrafluorocyclohexane aldehydes. Organic & Biomolecular Chemistry. 14: 1117-23. PMID 26646211 DOI: 10.1039/C5Ob02334C  1
2016 Harper DB, O'Hagan D, Murphy CD. Fluorinated natural products: Occurrence and biosynthesis Handbook of Environmental Chemistry. 3: 141-169. DOI: 10.1007/b10454  1
2015 Ma L, Bartholome A, Tong MH, Qin Z, Yu Y, Shepherd T, Kyeremeh K, Deng H, O'Hagan D. Identification of a fluorometabolite from sp. MA37: (234)-5-fluoro-2,3,4-trihydroxypentanoic acid. Chemical Science. 6: 1414-1419. PMID 29861965 DOI: 10.1039/C4Sc03540B  1
2015 Ayoup MS, Cordes DB, Slawin AM, O'Hagan D. Selectively fluorinated cyclohexane building blocks: Derivatives of carbonylated all-cis-3-phenyl-1,2,4,5-tetrafluorocyclohexane. Beilstein Journal of Organic Chemistry. 11: 2671-6. PMID 26877788 DOI: 10.3762/Bjoc.11.287  1
2015 Bello D, O'Hagan D. Lewis acid-promoted hydrofluorination of alkynyl sulfides to generate α-fluorovinyl thioethers. Beilstein Journal of Organic Chemistry. 11: 1902-9. PMID 26664609 DOI: 10.3762/Bjoc.11.205  1
2015 Thompson S, McMahon SA, Naismith JH, O'Hagan D. Exploration of a potential difluoromethyl-nucleoside substrate with the fluorinase enzyme. Bioorganic Chemistry. 64: 37-41. PMID 26642178 DOI: 10.1016/J.Bioorg.2015.11.003  1
2015 Corr MJ, Cormanich RA, von Hahmann CN, Bühl M, Cordes DB, Slawin AM, O'Hagan D. Fluorine in fragrances: exploring the difluoromethylene (CF2) group as a conformational constraint in macrocyclic musk lactones. Organic & Biomolecular Chemistry. PMID 26584449 DOI: 10.1039/C5Ob02023A  1
2015 Cormanich RA, Keddie NS, Rittner R, O'Hagan D, Bühl M. Particularly strong C-Hπ interactions between benzene and all-cis 1,2,3,4,5,6-hexafluorocyclohexane. Physical Chemistry Chemical Physics : Pccp. 17: 29475-8. PMID 26507700 DOI: 10.1039/C5Cp04537A  1
2015 Nahra F, Patrick SR, Bello D, Brill M, Obled A, Cordes DB, Slawin AM, O'Hagan D, Nolan SP. Hydrofluorination of Alkynes Catalysed by Gold Bifluorides. Chemcatchem. 7: 240-244. PMID 26236406 DOI: 10.1002/Cctc.201402891  1
2015 Thompson S, Onega M, Ashworth S, Fleming IN, Passchier J, O'Hagan D. A two-step fluorinase enzyme mediated (18)F labelling of an RGD peptide for positron emission tomography. Chemical Communications (Cambridge, England). 51: 13542-5. PMID 26221637 DOI: 10.1039/C5Cc05013H  1
2015 Keddie NS, Slawin AM, Lebl T, Philp D, O'Hagan D. All-cis 1,2,3,4,5,6-hexafluorocyclohexane is a facially polarized cyclohexane. Nature Chemistry. 7: 483-8. PMID 25991526 DOI: 10.1038/Nchem.2232  1
2015 Cormanich RA, Rittner R, O'Hagan D, Bühl M. Inter- and intramolecular CF···co interactions on aliphatic and cyclohexane carbonyl derivatives. Journal of Computational Chemistry. PMID 25903504 DOI: 10.1002/Jcc.23918  1
2015 Ayoup MS, Cordes DB, Slawin AM, O'Hagan D. Fluorine containing amino acids: synthesis and peptide coupling of amino acids containing the all-cis tetrafluorocyclohexyl motif. Organic & Biomolecular Chemistry. 13: 5621-4. PMID 25900403 DOI: 10.1039/C5Ob00650C  1
2015 di Gesso JL, Kerr JS, Zhang Q, Raheem S, Yalamanchili SK, O'Hagan D, Kay CD, O'Connell MA. Flavonoid metabolites reduce tumor necrosis factor-α secretion to a greater extent than their precursor compounds in human THP-1 monocytes. Molecular Nutrition & Food Research. 59: 1143-54. PMID 25801720 DOI: 10.1002/Mnfr.201400799  1
2015 O'Hagan D, Deng H. Enzymatic fluorination and biotechnological developments of the fluorinase. Chemical Reviews. 115: 634-49. PMID 25253234 DOI: 10.1021/cr500209t  1
2015 Absalom N, Yamamoto I, O'Hagan D, Hunter L, Chebib M. Probing the Mode of Neurotransmitter Binding to GABA Receptors Using Selectively Fluorinated GABA Analogues Australian Journal of Chemistry. 68: 23-30. DOI: 10.1071/Ch14456  1
2015 Ma L, Bartholome A, Tong MH, Qin Z, Yu Y, Shepherd T, Kyeremeh K, Deng H, O'Hagan D. Identification of a fluorometabolite from Streptomyces sp. MA37: (2R3S4S)-5-fluoro-2,3,4-trihydroxypentanoic acid Chemical Science. 6: 1414-1419. DOI: 10.1039/c4sc03540b  1
2015 Nahra F, Patrick SR, Bello D, Brill M, Obled A, Cordes DB, Slawin AMZ, O'Hagan D, Nolan SP. Hydrofluorination of alkynes catalysed by gold bifluorides Chemcatchem. 7: 240-244. DOI: 10.1002/cctc.201402891  1
2014 Adamkiewicz M, O'Hagan D, Hähner G. Organic chemistry on surfaces: Direct cyclopropanation by dihalocarbene addition to vinyl terminated self-assembled monolayers (SAMs). Beilstein Journal of Organic Chemistry. 10: 2897-902. PMID 25550756 DOI: 10.3762/bjoc.10.307  1
2014 Cormanich RA, Rittner R, O'Hagan D, Bühl M. Analysis of CF···FC interactions on cyclohexane and naphthalene frameworks. The Journal of Physical Chemistry. A. 118: 7901-10. PMID 25127203 DOI: 10.1021/Jp504568C  1
2014 Durie AJ, Fujiwara T, Al-Maharik N, Slawin AM, O'Hagan D. Stepwise preparation of all-cis 1,3,4-trifluoro-2-phenylcyclohexane, avoiding a phenonium intermediate. The Journal of Organic Chemistry. 79: 8228-33. PMID 25102142 DOI: 10.1021/jo501432x  1
2014 Thompson S, Zhang Q, Onega M, McMahon S, Fleming I, Ashworth S, Naismith JH, Passchier J, O'Hagan D. A localized tolerance in the substrate specificity of the fluorinase enzyme enables "last-step" 18F fluorination of a RGD peptide under ambient aqueous conditions. Angewandte Chemie (International Ed. in English). 53: 8913-8. PMID 24989327 DOI: 10.1002/Anie.201403345  1
2014 Huang S, Ma L, Tong MH, Yu Y, O'Hagan D, Deng H. Fluoroacetate biosynthesis from the marine-derived bacterium Streptomyces xinghaiensis NRRL B-24674. Organic & Biomolecular Chemistry. 12: 4828-31. PMID 24903341 DOI: 10.1039/C4Ob00970C  1
2014 Ayoup MS, Cordes DB, Slawin AM, O'Hagan D. Total synthesis of a reported fluorometabolite from Streptomyces sp. TC1 indicates an incorrect assignment. The isolated compound did not contain fluorine. Journal of Natural Products. 77: 1249-51. PMID 24848452 DOI: 10.1021/Np500260Z  1
2014 Adamkiewicz M, O'Hagan D, Hähner G. Bis(trifluoromethyl)methylene addition to vinyl-terminated SAMs: a gas-phase C-C bond-forming reaction on a surface. Langmuir : the Acs Journal of Surfaces and Colloids. 30: 5422-8. PMID 24806554 DOI: 10.1021/la5011727  1
2014 Durie AJ, Fujiwara T, Cormanich R, Bühl M, Slawin AM, O'Hagan D. Synthesis and elaboration of all-cis-1,2,4,5-tetrafluoro-3-phenylcyclohexane: a polar cyclohexane motif. Chemistry (Weinheim An Der Bergstrasse, Germany). 20: 6259-63. PMID 24740763 DOI: 10.1002/Chem.201400354  1
2014 Wang Y, Callejo R, Slawin AM, O'Hagan D. The difluoromethylene (CF2) group in aliphatic chains: Synthesis and conformational preference of palmitic acids and nonadecane containing CF2 groups. Beilstein Journal of Organic Chemistry. 10: 18-25. PMID 24454560 DOI: 10.3762/bjoc.10.4  1
2014 Deng H, Ma L, Bandaranayaka N, Qin Z, Mann G, Kyeremeh K, Yu Y, Shepherd T, Naismith JH, O'Hagan D. Identification of fluorinases from Streptomyces sp MA37, Norcardia brasiliensis, and Actinoplanes sp N902-109 by genome mining. Chembiochem : a European Journal of Chemical Biology. 15: 364-8. PMID 24449539 DOI: 10.1002/Cbic.201300732  1
2014 Nortcliffe A, Ekstrom AG, Black JR, Ross JA, Habib FK, Botting NP, O'Hagan D. Synthesis and biological evaluation of nitric oxide-donating analogues of sulindac for prostate cancer treatment. Bioorganic & Medicinal Chemistry. 22: 756-61. PMID 24387865 DOI: 10.1016/J.Bmc.2013.12.014  1
2014 Nortcliffe A, Fleming IN, Botting NP, O'Hagan D. Synthesis and anticancer properties of RGD peptides conjugated to nitric oxide releasing functional groups and abiraterone Tetrahedron. 70: 8343-8347. DOI: 10.1016/J.Tet.2014.09.004  1
2013 O'Hagan D. Organo-fluorine chemistry III. Beilstein Journal of Organic Chemistry. 9: 2180-1. PMID 24204430 DOI: 10.3762/bjoc.9.255  0.01
2013 Skibi?ski M, Urbina-Blanco CA, Slawin AM, Nolan SP, O'Hagan D. Synthesis and structure of large difluoromethylene containing alicycles by ring closing metathesis (RCM). Organic & Biomolecular Chemistry. 11: 8209-13. PMID 24162143 DOI: 10.1039/C3Ob42062K  1
2013 Urbina-Blanco CA, Skibi?ski M, O'Hagan D, Nolan SP. Accelerating influence of the gem-difluoromethylene group in a ring-closing olefin metathesis reaction. A Thorpe-Ingold effect? Chemical Communications (Cambridge, England). 49: 7201-3. PMID 23842904 DOI: 10.1039/C3Cc44312D  1
2013 Nortcliffe A, Botting NP, O'Hagan D. Novel amino acids: synthesis of furoxan and sydnonimine containing amino acids and peptides as potential nitric oxide releasing motifs. Organic & Biomolecular Chemistry. 11: 4657-71. PMID 23753002 DOI: 10.1039/C3Ob41047A  1
2013 Dall'Angelo S, Zhang Q, Fleming IN, Piras M, Schweiger LF, O'Hagan D, Zanda M. Efficient bioconjugation of 5-fluoro-5-deoxy-ribose (FDR) to RGD peptides for positron emission tomography (PET) imaging of α(v)β(3) integrin receptor. Organic & Biomolecular Chemistry. 11: 4551-8. PMID 23733207 DOI: 10.1039/C3Ob40550H  1
2013 Dall'Angelo S, Bandaranayaka N, Windhorst AD, Vugts DJ, van der Born D, Onega M, Schweiger LF, Zanda M, O'Hagan D. Tumour imaging by Positron Emission Tomography using fluorinase generated 5-[¹⁸F]fluoro-5-deoxyribose as a novel tracer. Nuclear Medicine and Biology. 40: 464-70. PMID 23541025 DOI: 10.1016/J.Nucmedbio.2013.02.006  1
2013 Chan KK, Thompson S, O'Hagan D. The mechanisms of radical SAM/cobalamin methylations: an evolving working hypothesis. Chembiochem : a European Journal of Chemical Biology. 14: 675-7. PMID 23526745 DOI: 10.1002/Cbic.201200762  1
2013 Chia PW, Bello D, Slawin AM, O'Hagan D. Fluorinated 5- and 7-membered carbacycle motifs by reaction of difluorocarbene with acetylene ethers. Chemical Communications (Cambridge, England). 49: 2189-91. PMID 23385787 DOI: 10.1039/C3Cc39066G  1
2012 Chan KK, O'Hagan D. The rare fluorinated natural products and biotechnological prospects for fluorine enzymology. Methods in Enzymology. 516: 219-35. PMID 23034231 DOI: 10.1016/B978-0-12-394291-3.00003-4  1
2012 Wang Y, Kirsch P, Lebl T, Slawin AM, O'Hagan D. The preferred conformation of erythro- and threo-1,2-difluorocyclododecanes. Beilstein Journal of Organic Chemistry. 8: 1271-8. PMID 23019458 DOI: 10.3762/Bjoc.8.143  1
2012 Durie AJ, Slawin AM, Lebl T, O'Hagan D. The synthesis of η-1,2,3,4,5,6-hexafluorocyclohexane (benzene hexafluoride) from benzene. Angewandte Chemie (International Ed. in English). 51: 10086-8. PMID 22968946 DOI: 10.1002/Anie.201205577  1
2012 Chia PW, Brennan SC, Slawin AMZ, Riccardi D, O'Hagan D. Allosteric agonists of the calcium receptor (CaR): Fluorine and SF 5 analogues of cinacalcet Organic and Biomolecular Chemistry. 10: 7922-7927. PMID 22940747 DOI: 10.1039/C2Ob26402A  1
2012 Durie AJ, Slawin AM, Lebl T, Kirsch P, O'Hagan D. Fluorocyclohexanes: synthesis and structure of all-syn-1,2,4,5-tetrafluorocyclohexane. Chemical Communications (Cambridge, England). 48: 9643-5. PMID 22911247 DOI: 10.1039/C2Cc34679F  1
2012 Zhao C, Li P, Deng Z, Ou HY, McGlinchey RP, O'Hagan D. Insights into fluorometabolite biosynthesis in Streptomyces cattleya DSM46488 through genome sequence and knockout mutants. Bioorganic Chemistry. 44: 1-7. PMID 22858315 DOI: 10.1016/J.Bioorg.2012.06.002  1
2012 Chia PW, Livesey MR, Slawin AM, van Mourik T, Wyllie DJ, O'Hagan D. 3-Fluoro-N-methyl-D-aspartic acid (3F-NMDA) stereoisomers as conformational probes for exploring agonist binding at NMDA receptors. Chemistry (Weinheim An Der Bergstrasse, Germany). 18: 8813-9. PMID 22692769 DOI: 10.1002/Chem.201200071  1
2012 Li XG, Dall'Angelo S, Schweiger LF, Zanda M, O'Hagan D. [18F]-5-Fluoro-5-deoxyribose, an efficient peptide bioconjugation ligand for positron emission tomography (PET) imaging. Chemical Communications (Cambridge, England). 48: 5247-9. PMID 22476360 DOI: 10.1039/C2Cc31262J  1
2012 O'Hagan D. Organofluorine chemistry: synthesis and conformation of vicinal fluoromethylene motifs. The Journal of Organic Chemistry. 77: 3689-99. PMID 22404655 DOI: 10.1021/jo300044q  0.01
2012 Freitas MP, Bühl M, O'Hagan D. 1,2-Difluoroethane: the angular dependance on 1J(CF) coupling constants is independent of hyperconjugation. Chemical Communications (Cambridge, England). 48: 2433-5. PMID 22274569 DOI: 10.1039/C2Cc17180E  1
2012 Freitas MP, Bühl M, O'Hagan D, Cormanich RA, Tormena CF. Stereoelectronic interactions and the one-bond C-F coupling constant in sevoflurane. The Journal of Physical Chemistry. A. 116: 1677-82. PMID 22233417 DOI: 10.1021/jp211949m  1
2012 Surya Prakash GK, Wang F, O'Hagan D, Hu J, Ding K, Dai LX. Flourishing Frontiers in Organofluorine Chemistry Organic Chemistry - Breakthroughs and Perspectives. 413-476. DOI: 10.1002/9783527664801.ch12  1
2011 Skibinski M, Wang Y, Slawin AM, Lebl T, Kirsch P, O'Hagan D. Alicyclic ring structure: conformational influence of the CF2 group in cyclododecanes. Angewandte Chemie (International Ed. in English). 50: 10581-4. PMID 21932273 DOI: 10.1002/Anie.201105060  1
2011 Jurčík V, Slawin AM, O'Hagan D. Single enantiomer synthesis of α-(trifluoromethyl)-β-lactam. Beilstein Journal of Organic Chemistry. 7: 759-66. PMID 21804871 DOI: 10.3762/Bjoc.7.86  1
2011 Durie AJ, Slawin AM, Lebl T, Kirsch P, O'Hagan D. Synthesis and structure of all-syn-1,2,3,4-tetrafluorocyclohexane. Chemical Communications (Cambridge, England). 47: 8265-7. PMID 21709894 DOI: 10.1039/C1Cc13016A  1
2011 Yamamoto I, Deniau GP, Gavande N, Chebib M, Johnston GA, O'Hagan D. Agonist responses of (R)- and (S)-3-fluoro-γ-aminobutyric acids suggest an enantiomeric fold for GABA binding to GABA(C) receptors. Chemical Communications (Cambridge, England). 47: 7956-8. PMID 21670807 DOI: 10.1039/C1Cc12141C  1
2011 O'Hagan D. 3-fluoro-GABA enantiomers: exploring the conformation of GABA binding to GABAA receptors and GABA aminotransferase. Future Medicinal Chemistry. 3: 189-95. PMID 21428814 DOI: 10.4155/fmc.10.295  0.01
2011 Campbell NH, Smith DL, Reszka AP, Neidle S, O'Hagan D. Fluorine in medicinal chemistry: β-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNA Organic and Biomolecular Chemistry. 9: 1328-1331. PMID 21221451 DOI: 10.1039/C0Ob00886A  1
2010 Li XG, Domarkas J, O'Hagan D. Fluorinase mediated chemoenzymatic synthesis of [(18)F]-fluoroacetate. Chemical Communications (Cambridge, England). 46: 7819-21. PMID 20852791 DOI: 10.1039/C0Cc02264K  1
2010 Bresciani S, Lebl T, Slawin AM, O'Hagan D. Fluorosugars: synthesis of the 2,3,4-trideoxy-2,3,4-trifluoro hexose analogues of D-glucose and D-altrose and assessment of their erythrocyte transmembrane transport. Chemical Communications (Cambridge, England). 46: 5434-6. PMID 20532277 DOI: 10.1039/C0Cc01128B  1
2010 O'Hagan D. Organo-fluorine chemistry II. Beilstein Journal of Organic Chemistry. 6: 36. PMID 20502657 DOI: 10.3762/Bjoc.6.36  0.01
2010 Launay GG, Slawin AM, O'Hagan D. Prins fluorination cyclisations: Preparation of 4-fluoro-pyran and -piperidine heterocycles. Beilstein Journal of Organic Chemistry. 6: 41. PMID 20502655 DOI: 10.3762/Bjoc.6.41  1
2010 Bonnet N, O'Hagan D, Hähner G. Protein adsorption onto CF(3)-terminated oligo(ethylene glycol) containing self-assembled monolayers (SAMs): the influence of ionic strength and electrostatic forces. Physical Chemistry Chemical Physics : Pccp. 12: 4367-74. PMID 20407708 DOI: 10.1039/B923065N  1
2010 O'Hagan D, Schmidberger JW. Enzymes that catalyse SN2 reaction mechanisms. Natural Product Reports. 27: 900-18. PMID 20372740 DOI: 10.1039/B919371P  0.01
2010 Eustáquio AS, O'Hagan D, Moore BS. Engineering fluorometabolite production: fluorinase expression in Salinispora tropica Yields Fluorosalinosporamide. Journal of Natural Products. 73: 378-82. PMID 20085308 DOI: 10.1021/Np900719U  1
2010 Onega M, Domarkas J, Deng H, Schweiger LF, Smith TA, Welch AE, Plisson C, Gee AD, O'Hagan D. An enzymatic route to 5-deoxy-5-[18F]fluoro-D-ribose, a [18F]-fluorinated sugar for PET imaging. Chemical Communications (Cambridge, England). 46: 139-41. PMID 20024319 DOI: 10.1039/B919364B  1
2009 Onega M, Winkler M, O'Hagan D. Fluorinase: a tool for the synthesis of ¹⁸F-labeled sugars and nucleosides for PET. Future Medicinal Chemistry. 1: 865-73. PMID 21426085 DOI: 10.4155/fmc.09.74  1
2009 Brunet VA, Slawin AM, O'Hagan D. Three step synthesis of single diastereoisomers of the vicinal trifluoro motif. Beilstein Journal of Organic Chemistry. 5: 61. PMID 20300509 DOI: 10.3762/Bjoc.5.61  1
2009 Nasomjai P, O'Hagan D, Slawin AM. Synthesis of phosphonate and phostone analogues of ribose-1-phosphates. Beilstein Journal of Organic Chemistry. 5: 37. PMID 19777136 DOI: 10.3762/Bjoc.5.37  1
2009 Farran D, Slawin AMZ, Kirsch P, O'Hagan D. Diastereoselective synthesis of 2,3,4,5,6-pentafluoroheptanes Journal of Organic Chemistry. 74: 7168-7171. PMID 19694412 DOI: 10.1021/jo901360e  1
2009 Nasomjai P, Reed DW, Tozer DJ, Peach MJ, Slawin AM, Covello PS, O'Hagan D. Mechanistic insights into the cytochrome P450-mediated oxidation and rearrangement of littorine in tropane alkaloid biosynthesis. Chembiochem : a European Journal of Chemical Biology. 10: 2382-93. PMID 19693762 DOI: 10.1002/Cbic.200900318  1
2009 Hunter L, Kirsch P, Slawin AM, O'Hagan D. Synthesis and structure of stereoisomeric multivicinal hexafluoroalkanes. Angewandte Chemie (International Ed. in English). 48: 5457-60. PMID 19551794 DOI: 10.1002/Anie.200901956  1
2009 Winkler M, Moraux T, Khairy HA, Scott RH, Slawin AM, O'Hagan D. Synthesis and vanilloid receptor (TRPV1) activity of the enantiomers of alpha-fluorinated capsaicin. Chembiochem : a European Journal of Chemical Biology. 10: 823-8. PMID 19267374 DOI: 10.1002/Cbic.200800709  1
2009 Patole SN, Baddeley CJ, Schüler M, O'Hagan D, Richardson NV. Driving forces underlying the formation of chiral domains of fluorinated diacids on graphite. Langmuir : the Acs Journal of Surfaces and Colloids. 25: 1412-6. PMID 19090653 DOI: 10.1021/La802170F  1
2008 Deng H, Cross SM, McGlinchey RP, Hamilton JT, O'Hagan D. In vitro reconstituted biotransformation of 4-fluorothreonine from fluoride ion: application of the fluorinase. Chemistry & Biology. 15: 1268-76. PMID 19101471 DOI: 10.1016/J.Chembiol.2008.10.012  1
2008 Winkler M, Domarkas J, Schweiger LF, O'Hagan D. Fluorinase-coupled base swaps: synthesis of [18F]-5'-deoxy-5'-fluorouridines. Angewandte Chemie (International Ed. in English). 47: 10141-3. PMID 19034935 DOI: 10.1002/Anie.200804040  1
2008 O'Hagan D. Themed series in organo-fluorine chemistry. Beilstein Journal of Organic Chemistry. 4: 11. PMID 18941483 DOI: 10.3762/Bjoc.4.11  0.01
2008 Hunter L, Kirsch P, Hamilton JT, O'Hagan D. The multi-vicinal fluoroalkane motif: an examination of 2,3,4,5-tetrafluorohexane stereoisomers. Organic & Biomolecular Chemistry. 6: 3105-8. PMID 18698469 DOI: 10.1039/B807449F  1
2008 Hunter L, O'Hagan D. Multi-vicinal fluoroalkanes: a new class of organofluorine compounds. Organic & Biomolecular Chemistry. 6: 2843-8. PMID 18688475 DOI: 10.1039/B809432B  1
2008 Deng H, O'Hagan D. The fluorinase, the chlorinase and the duf-62 enzymes. Current Opinion in Chemical Biology. 12: 582-92. PMID 18675376 DOI: 10.1016/j.cbpa.2008.06.036  1
2008 Deng H, Botting CH, Hamilton JT, Russell RJ, O'Hagan D. S-adenosyl-L-methionine:hydroxide adenosyltransferase: a SAM enzyme. Angewandte Chemie (International Ed. in English). 47: 5357-61. PMID 18551689 DOI: 10.1002/Anie.200800794  1
2008 O'Hagan D, Allen V. Editorial: Synthesis themed issue. Natural Product Reports. 25: 215. PMID 18389134 DOI: 10.1039/b802687b  0.01
2008 O'Hagan D. Understanding organofluorine chemistry. An introduction to the C-F bond. Chemical Society Reviews. 37: 308-19. PMID 18197347 DOI: 10.1039/B711844A  0.01
2008 Brunet VA, O'Hagan D. Catalytic asymmetric fluorination comes of age. Angewandte Chemie (International Ed. in English). 47: 1179-82. PMID 18161722 DOI: 10.1002/Anie.200704700  1
2008 Patole SN, Baddeley CJ, O'Hagan D, Richardson NV. Reversible exchange of self-assembled monolayers of semifluorinated n-alkanethiols and n-alkanethiols on au/mica surfaces Journal of Physical Chemistry C. 112: 13997-14000. DOI: 10.1021/Jp804888G  1
2008 Deniau G, Sillar KT, O'Hagan D. Synthesis of fluorinated analogues of the neurosteroid GABAA receptor antagonist, 17-PA Journal of Fluorine Chemistry. 129: 881-887. DOI: 10.1016/j.jfluchem.2008.03.004  1
2008 Deng H, Huang FL, Naismith JH, O'Hagan D, Spencer JB, Zhu X. Biological Fluorination in Streptomyces cattleya: The Fluorinase Fluorine and Health. 761-777. DOI: 10.1016/B978-0-444-53086-8.00018-7  1
2007 Nicoletti M, Bremer M, Kirsch P, O'Hagan D. Liquid crystals carrying stereodefined vicinal difluoro- and trifluoro- alkyl motifs. Chemical Communications (Cambridge, England). 5075-7. PMID 18049758 DOI: 10.1039/B711839B  1
2007 Bonnet N, O'Hagan D, Hähner G. Ionic strength mediated hydrophobic force switching of CF3-terminated ethylene glycol self-assembled monolayers (SAMs) on gold. Chemical Communications (Cambridge, England). 5066-8. PMID 18049755 DOI: 10.1039/B712968H  1
2007 Deniau G, Slawin AM, Lebl T, Chorki F, Issberner JP, van Mourik T, Heygate JM, Lambert JJ, Etherington LA, Sillar KT, O'Hagan D. Synthesis, conformation and biological evaluation of the enantiomers of 3-fluoro-gamma-aminobutyric acid ((R)- and (S)-3F-GABA): an analogue of the neurotransmitter GABA. Chembiochem : a European Journal of Chemical Biology. 8: 2265-74. PMID 17990263 DOI: 10.1002/Cbic.200700371  1
2007 Clift MD, Ji H, Deniau GP, O'Hagan D, Silverman RB. Enantiomers of 4-amino-3-fluorobutanoic acid as substrates for γ-aminobutyric acid aminotransferase. Conformational probes for GABA binding Biochemistry. 46: 13819-13828. PMID 17988152 DOI: 10.1021/Bi701249Q  1
2007 Zhu X, Robinson DA, McEwan AR, O'Hagan D, Naismith JH. Mechanism of enzymatic fluorination in Streptomyces cattleya. Journal of the American Chemical Society. 129: 14597-604. PMID 17985882 DOI: 10.1021/Ja0731569  1
2007 Hunter L, Slawin AM, Kirsch P, O'Hagan D. Synthesis and conformation of multi-vicinal fluoroalkane diastereoisomers. Angewandte Chemie (International Ed. in English). 46: 7887-90. PMID 17786905 DOI: 10.1002/Anie.200701988  1
2007 Patole SN, Baddeley CJ, O'Hagan D, Richardson NV, Zerbetto F, Zotti LA, Teobaldi G, Hofer WA. Self-assembly of semifluorinated n-alkanethiols on {111}-oriented Au investigated with scanning tunneling microscopy experiment and theory. The Journal of Chemical Physics. 127: 024702. PMID 17640140 DOI: 10.1063/1.2746252  1
2007 Gooseman NE, O'Hagan D, Peach MJ, Slawin AM, Tozer DJ, Young RJ. An electrostatic gauche effect in beta-fluoro- and beta-hydroxy-N-ethylpyridinium cations. Angewandte Chemie (International Ed. in English). 46: 5904-8. PMID 17610229 DOI: 10.1002/Anie.200700714  1
2007 Onega M, McGlinchey RP, Deng H, Hamilton JT, O'Hagan D. The identification of (3R,4S)-5-fluoro-5-deoxy-D-ribulose-1-phosphate as an intermediate in fluorometabolite biosynthesis in Streptomyces cattleya. Bioorganic Chemistry. 35: 375-85. PMID 17574646 DOI: 10.1016/j.bioorg.2007.04.001  1
2006 Hunter L, O'Hagan D, Slawin AM. Enantioselective synthesis of an all-syn four vicinal fluorine motif. Journal of the American Chemical Society. 128: 16422-3. PMID 17177350 DOI: 10.1021/Ja066188P  1
2006 Gooseman NE, O'Hagan D, Slawin AM, Teale AM, Tozer DJ, Young RJ. The intramolecular beta-fluorine...ammonium interaction in 4- and 8-membered rings. Chemical Communications (Cambridge, England). 3190-2. PMID 17028739 DOI: 10.1039/B606334A  1
2006 O'Hagan D, Rzepa HS, Schüler M, Slawin AM. The vicinal difluoro motif: The synthesis and conformation of erythro- and threo- diastereoisomers of 1,2-difluorodiphenylethanes, 2,3-difluorosuccinic acids and their derivatives. Beilstein Journal of Organic Chemistry. 2: 19. PMID 17014729 DOI: 10.1186/1860-5397-2-19  1
2006 Huang F, Haydock SF, Spiteller D, Mironenko T, Li TL, O'Hagan D, Leadlay PF, Spencer JB. The gene cluster for fluorometabolite biosynthesis in Streptomyces cattleya: a thioesterase confers resistance to fluoroacetyl-coenzyme A. Chemistry & Biology. 13: 475-84. PMID 16720268 DOI: 10.1016/J.Chembiol.2006.02.014  1
2006 Deng H, Cobb SL, Gee AD, Lockhart A, Martarello L, McGlinchey RP, O'Hagan D, Onega M. Fluorinase mediated C-(18)F bond formation, an enzymatic tool for PET labelling. Chemical Communications (Cambridge, England). 652-4. PMID 16446840 DOI: 10.1039/B516861A  1
2006 Deng H, Cobb SL, McEwan AR, McGlinchey RP, Naismith JH, O'Hagan D, Robinson DA, Spencer JB. The fluorinase from Streptomyces cattleya is also a chlorinase. Angewandte Chemie (International Ed. in English). 45: 759-62. PMID 16370017 DOI: 10.1002/Anie.200503582  1
2005 Janik JE, Morris JC, Stetler-Stevenson M, Gao WW, O'Hagan D, Moses LS, Taylor M, McEwen C, Hammershaimb LD, Waldmann TA. Phase I trial of siplizumab in CD2-positive lymphoproliferative disease. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 23: 2533. PMID 27945817 DOI: 10.1200/Jco.2005.23.16_Suppl.2533  0.01
2005 Cobb SL, Deng H, Hamilton JT, McGlinchey RP, O'Hagan D, Schaffrath C. The identification of 5'-fluoro-5-deoxyinosine as a shunt product in cell free extracts of Streptomyces cattleya. Bioorganic Chemistry. 33: 393-401. PMID 16165185 DOI: 10.1016/j.bioorg.2005.07.002  1
2005 Varfolomeyev S, Efremenko E, Beletskaya I, Bertini I, Blackburn GM, Bogdanov A, Cunin R, Eichler J, Galaev I, Gladyshev V, O'Hagan D, Haertle T, Jarv J, Karyakin A, Kurochkin I, et al. Postgenomic chemistry (IUPAC Technical Report) Pure and Applied Chemistry. 77: 1641-1654. DOI: 10.1351/Pac200577091641  0.01
2005 O'Hagan D, Sandford G. Special Issue: Dedicated to Professor Richard D. Chambers FRS, on his 70th birthday Journal of Fluorine Chemistry. 126: 423-424. DOI: 10.1016/J.Jfluchem.2005.02.003  1
2004 Deng H, O'Hagan D, Schaffrath C. Fluorometabolite biosynthesis and the fluorinase from Streptomyces cattleya. Natural Product Reports. 21: 773-84. PMID 15565254 DOI: 10.1039/B415087M  1
2004 Cadicamo CD, Courtieu J, Deng H, Meddour A, O'Hagan D. Enzymatic fluorination in Streptomyces cattleya takes place with an inversion of configuration consistent with an SN2 reaction mechanism. Chembiochem : a European Journal of Chemical Biology. 5: 685-90. PMID 15122641 DOI: 10.1002/Cbic.200300839  1
2004 Briggs CR, Allen MJ, O'Hagan D, Tozer DJ, Slawin AM, Goeta AE, Howard JA. The observation of a large gauche preference when 2-fluoroethylamine and 2-fluoroethanol become protonated. Organic & Biomolecular Chemistry. 2: 732-40. PMID 14985814 DOI: 10.1039/B312188G  1
2004 Cobb SL, Deng H, Hamilton JT, McGlinchey RP, O'Hagan D. Identification of 5-fluoro-5-deoxy-D-ribose-1-phosphate as an intermediate in fluorometabolite biosynthesis in Streptomyces cattleya. Chemical Communications (Cambridge, England). 592-3. PMID 14973623 DOI: 10.1039/B400754A  1
2004 Dong C, Huang F, Deng H, Schaffrath C, Spencer JB, O'Hagan D, Naismith JH. Crystal structure and mechanism of a bacterial fluorinating enzyme. Nature. 427: 561-5. PMID 14765200 DOI: 10.1038/Nature02280  1
2003 Schaffrath C, Deng H, O'Hagan D. Isolation and characterisation of 5'-fluorodeoxyadenosine synthase, a fluorination enzyme from Streptomyces cattleya. Febs Letters. 547: 111-4. PMID 12860396 DOI: 10.1016/S0014-5793(03)00688-4  1
2003 O'Hagan D, Goss RJ, Meddour A, Courtieu J. Assay for the enantiomeric analysis of [2H1]-fluoroacetic acid: insight into the stereochemical course of fluorination during fluorometabolite biosynthesis in streptomyces cattleya. Journal of the American Chemical Society. 125: 379-87. PMID 12517149 DOI: 10.1021/ja026654k  1
2002 Schaffrath C, Cobb SL, O'Hagan D. Cell-free biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomyces cattleya. Angewandte Chemie (International Ed. in English). 41: 3913-5. PMID 12386890 DOI: 10.1002/1521-3773(20021018)41:20<3913::Aid-Anie3913>3.0.Co;2-E  1
2002 Tavasli M, Courtieu J, Goss RJ, Meddour A, O'Hagan D. Extreme enantiomeric discrimination of fluoroalkanes using deuterium NMR in chiral liquid crystalline media. Chemical Communications (Cambridge, England). 844-5. PMID 12123007 DOI: 10.1039/B200992G  1
2002 Tavasli M, O'Hagan D, Pearson C, Petty MC. The fluorine gauche effect. Langmuir isotherms report the relative conformational stability of (+/-)-erythro- and (+/-)-threo-9,10-difluorostearic acids. Chemical Communications (Cambridge, England). 1226-7. PMID 12109094 DOI: 10.1039/B202891C  1
2002 O'Hagan D, Schaffrath C, Cobb SL, Hamilton JT, Murphy CD. Biochemistry: biosynthesis of an organofluorine molecule. Nature. 416: 279. PMID 11907567 DOI: 10.1038/416279A  1
2002 Nicoletti M, O'Hagan D, Slawin AMZ. The asymmetric Bischler–Napieralski reaction: preparation of 1,3,4-trisubstituted 1,2,3,4-tetrahydroisoquinolines Journal of the Chemical Society-Perkin Transactions 1. 116-121. DOI: 10.1039/B106942J  1
2001 Murphy CD, Moss SJ, O'Hagan D. Isolation of an aldehyde dehydrogenase involved in the oxidation of fluoroacetaldehyde to fluoroacetate in Streptomyces cattleya. Applied and Environmental Microbiology. 67: 4919-21. PMID 11571203 DOI: 10.1128/Aem.67.10.4919-4921  1
2001 Schaffrath C, Murphy CD, Hamilton JTG, O'Hagan D. Biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomyces cattleya. Incorporation of oxygen-18 from [2-2H,2-18O]-glycerol and the role of serine metabolites in fluoroacetaldehyde biosynthesis Journal of the Chemical Society-Perkin Transactions 1. 3100-3105. DOI: 10.1039/B108720G  1
2001 O'Hagan D, Sandford G. The taming of fluorine Chemistry in Britain. 37: 32-35.  1
2000 O'Hagan D, Bilton C, Howard JAK, Knight L, Tozer DJ. The preferred conformation of N-β-fluoroethylamides. Observation of the fluorine amide gauche effect Journal of the Chemical Society. Perkin Transactions 2. 605-607. DOI: 10.1039/B000205O  1
1999 Fowler DJ, Hamilton JTG, Humphrey AJ, O'Hagan D. Plant terpene biosynthesis. The biosynthesis of linalyl acetate in Mentha citrata Tetrahedron Letters. 40: 3803-3806. DOI: 10.1016/S0040-4039(99)00532-8  1
1998 Zabetakis I, Edwards R, Hamilton JTG, O'Hagan D. The biosynthetic relationship between littorine and hyoscyamine in transformed roots of Datura stramonium Plant Cell Reports. 18: 341-345. PMID 30744247 DOI: 10.1007/S002990050583  1
1998 Acsadi G, O'Hagan D, Lochmüller H, Prescott S, Larochelle N, Nalbantoglu J, Jani A, Karpati G. Interferons impair early transgene expression by adenovirus-mediated gene transfer in muscle cells Journal of Molecular Medicine. 76: 442-450. PMID 9625301 DOI: 10.1007/s001090050236  1
1998 Moore MC, Russell JC, Duffin GR, O'Hagan D. Synthesis and evaluation of a putative acyl tetramic acid intermediate in tenellin biosynthesis in Beauveria bassiana. A new role for tyrosine Tetrahedron. 54: 9195-9206. DOI: 10.1016/S0040-4020(98)00557-2  1
1997 Chesters NCJE, O'Hagan D. Biosynthesis of the fungal metabolite, piliformic acid(2-hexylidene-3-methylsuccinic acid) Journal of the Chemical Society-Perkin Transactions 1. 827-834. DOI: 10.1039/A606589I  1
1997 Bailey DJ, O'Hagan D, Tavasli M. A short synthesis of (S)-2-(diphenylmethyl) pyrrolidine, a chiral solvating agent for NMR analysis Tetrahedron Asymmetry. 8: 149-153. DOI: 10.1016/S0957-4166(96)00495-8  1
1996 Reineke N, Zaidi NA, Mitra M, O'Hagan D, Batsanov AS, Howard JAK, Naumov DY. A one-step photocatalytic synthesis of 2-(trifluoromethyl)butyrolactones Journal of the Chemical Society-Perkin Transactions 1. 147-150. DOI: 10.1039/P19960000147  1
1996 Chesters NCJE, Walker K, O'Hagan D, Floss HG. The biosynthesis of tropic acid: A reevaluation of the stereochemical course of the conversion of phenyllactate to tropate in Datura stramonium Journal of the American Chemical Society. 118: 925-926. DOI: 10.1021/Ja9531485  1
1995 O'Hagan D, Rogers SV, Duffin GR, Reynolds KA. The biosynthesis of monensin-A: Thymine, β-aminoisobutyrate and methacrylate metabolism in Streptomyces cinnamonensis Journal of Antibiotics. 48: 1280-1287. PMID 8557569 DOI: 10.7164/Antibiotics.48.1280  1
1995 Dasaradhi L, O'Hagan D, Petty MC, Pearson C. Synthesis and characterisation of selectively fluorinated stearic acids (octadecanoic acids) and their tristearins: the effect of introducing one and two fluorine atoms into a hydrocarbon chain Journal of the Chemical Society-Perkin Transactions 1. 221-225. DOI: 10.1039/P29950000221  1
1995 Robins RJ, Chesters NCJE, O'Hagan D, Parr AJ, Walton NJ, Woolley JG. The biosynthesis of hyoscyamine: the process by which littorine rearranges to hyoscyamine Journal of the Chemical Society-Perkin Transactions 1. 481-485. DOI: 10.1039/P19950000481  1
1995 Bridge CF, O'Hagan D, Reynolds KA, Wallace KK. Kinetic and stereoelectronic effects of a fluorine substituent on the reaction catalysed by an NADPH-dependent cyclohex-1-enylcarbonyl CoA reductase Journal of the Chemical Society, Chemical Communications. 2329-2330. DOI: 10.1039/C39950002329  1
1995 Nieschalk J, O'Hagan D. Monofluorophosphonates as phosphate mimics in bioorganic chemistry: a comparative study of CH2-, CHF- and CF2-phosphonate analogues of sn-glycerol-3-phosphate as substrates for sn-glycerol-3-phosphate dehydrogenase Journal of the Chemical Society, Chemical Communications. 719-720. DOI: 10.1039/C39950000719  0.01
1995 Chesters NCJE, O'Hagan D, Robins RJ, Kastelle A, Floss HG. The biosynthesis of tropic acid: The stereochemical course of the mutase involved in hyoscyamine biosynthesis in Datura stramonium Journal of the Chemical Society - Series Chemical Communications. 129-130. DOI: 10.1039/C39950000129  1
1995 Chesters NCJE, O'hagan D, Robins RJ. The biosynthesis of tropic acid: the (R)-D-phenyllactyl moiety is processed by the mutase involved in hyoscyamine biosynthesis in Datura stramonium Journal of the Chemical Society, Chemical Communications. 127-128. DOI: 10.1039/C39950000127  1
1994 O'Hagan D, Rzepa HS. Stereoelectronic influence of fluorine in enzyme resolutions of α-fluoroesters Journal of the Chemical Society-Perkin Transactions 1. 3-4. DOI: 10.1039/P29940000003  1
1994 Chesters NCJE, O'Hagan D, Robins RJ. The biosynthesis of tropic acid in plants: evidence for the direct rearrangement of 3-phenyllactate to tropate Journal of the Chemical Society-Perkin Transactions 1. 1159-1162. DOI: 10.1039/P19940001159  1
1994 O'Hagan D, Rzepa HS. Stereospecific control of the citrate synthase mediated synthesis of (2R,3R)-3-fluorocitrate by the relative stabilities of the intermediate fluoroenolates Journal of the Chemical Society, Chemical Communications. 2029-2030. DOI: 10.1039/C39940002029  1
1994 O'Hagan D, Rogers SV, Reynolds KA, Duffin GR. The incorporation of thymine and β-aminoisobutyrate into the polyether antibiotic, monensin-A Journal of the Chemical Society, Chemical Communications. 1577-1578. DOI: 10.1039/C39940001577  1
1993 O'Hagan D, Zaidi NA. Polymerisation of 10-hydroxydecanoic acid with the lipase from Candida cylindracea Journal of the Chemical Society-Perkin Transactions 1. 2389-2390. DOI: 10.1039/P19930002389  1
1993 Casher O, O'Hagan D, Rosenkranz CA, Rzepa HS, Zaidi NA. Electronic effects in π-facially stereoselective epoxidation of phenyltrifluoromethylpropenol Journal of the Chemical Society, Chemical Communications. 1337-1340. DOI: 10.1039/C39930001337  1
1993 Mocek U, Zeng Z, O'Hagan D, Zhou P, Fan LDG, Beale JM, Floss HG. Biosynthesis of the modified peptide antibiotic thiostrepton in Streptomyces azureus and Streptomyces laurentii Journal of the American Chemical Society. 115: 7992-8001. DOI: 10.1021/Ja00071A009  1
1993 O'Hagan D, Perry R, Lock JM, Meyer JJM, Dasaradhi L, Hamilton JTG, Harper DB. High levels of monofluoroacetate in Dichapetalum braunii Phytochemistry. 33: 1043-1045. DOI: 10.1016/0031-9422(93)85020-R  1
1992 O'Hagan D, Zaidi NA. Hydrolytic resolution of tertiary acetylenic acetate esters with the lipase from Candida cylindracea Journal of the Chemical Society-Perkin Transactions 1. 947-949. DOI: 10.1039/P19920000947  1
1991 Cox RJ, O'Hagan D. Synthesis of isotopically labelled 3-amino-2-phenylpropionic acid and its role as a precursor in the biosynthesis of tenellin and tropic acid Journal of the Chemical Society-Perkin Transactions 1. 2537-2540. DOI: 10.1039/P19910002537  0.01
1990 Chambers RD, O'Hagan D, Lamont RB, Jaina SC. The difluoromethylenephosphonate moiety as a phosphate mimic: X-ray structure of 2-amino-1,1-difluoroethylphosphonic acid Journal of the Chemical Society, Chemical Communications. 1053-1054. DOI: 10.1039/C39900001053  1
1989 Zhou P, O'Hagan D, Mocek U, Zeng Z, Yuen LD, Frenzel T, Unkefer CJ, Beale JM, Floss HG. Biosynthesis of the antibiotic thiostrepton. Methylation of tryptophan in the formation of the quinaldic acid moiety by transfer of the methionine methyl group with net retention of configuration Journal of the American Chemical Society. 111: 7274-7276. DOI: 10.1021/Ja00200A065  1
1989 Chambers RD, Jaouhari R, O'Hagan D. Fluorine in enzyme chemistry part 2 The preparation of difluoromethylenephosphonate analogues of glycolytic phosphates. Approaching an isosteric and isoelectronic phosphate mimic Tetrahedron. 45: 5101-5108. DOI: 10.1016/S0040-4020(01)81089-9  1
1989 Chambers RD, Jaouhari R, O'Hagan D. Fluorine in enzyme Chemistry: Part 1. Synthesis of difluoromethylenephosphonate derivatives as phosphate mimics Journal of Fluorine Chemistry. 44: 275-284. DOI: 10.1016/S0022-1139(00)83944-5  1
1988 Reynolds KA, O'Hagan D, Gani D, Robinson JA. Butyrate metabolism in streptomycetes. Characterization of an intramolecular vicinal interchange rearrangement linking isobutyrate and butyrate in Streptomyces cinnamonensis Journal of the Chemical Society, Perkin Transactions 1. 3195-3207. DOI: 10.1039/P19880003195  1
1988 Chambers RD, Jaouhari R, O'Hagan D. Synthesis of a difluoromethylenephosphonate analogue of glycerol-3-phosphate. A substrate for NADH linked glycerol-3-phosphate dehydrogenase Journal of the Chemical Society, Chemical Communications. 1169-1170. DOI: 10.1039/C39880001169  1
1985 Gani D, O'Hagan D, Reynolds K, Robinson JA. Biosynthesis of the polyether antibiotic monensin-A: Stereochemical aspects of the incorporation and metabolism of isobutyrate Journal of the Chemical Society, Chemical Communications. 1002-1004. DOI: 10.1039/C39850001002  1
1983 O'Hagan D, Robinson JA, Turner DL. Biosynthesis of the macrolide antibiotic tylosin. Origin of the oxygen atoms in tylactone Journal of the Chemical Society, Chemical Communications. 1337-1340. DOI: 10.1039/C39830001337  1
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