Jason M. Shearer, Ph.D. - Publications

Affiliations: 
Chemistry University of Nevada, Reno, Reno, NV, United States 
Area:
Bioinorganic Chemistry
Website:
http://www.chem.unr.edu/faculty/jms/

67 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Lee Y, Jeon IR, Abboud KA, García-Serres R, Shearer J, Murray LJ. A [3Fe-3S](3+) cluster with exclusively μ-sulfide donors. Chemical Communications (Cambridge, England). PMID 26603589 DOI: 10.1039/c5cc07813j  0.64
2015 Derrick JS, Kerr RA, Nam Y, Oh SB, Lee HJ, Earnest KG, Suh N, Peck KL, Ozbil M, Korshavn KJ, Ramamoorthy A, Prabhakar R, Merino EJ, Shearer J, Lee JY, et al. A Redox-Active, Compact Molecule for Cross-Linking Amyloidogenic Peptides into Nontoxic, Off-Pathway Aggregates: In Vitro and In Vivo Efficacy and Molecular Mechanisms. Journal of the American Chemical Society. 137: 14785-97. PMID 26575890 DOI: 10.1021/jacs.5b10043  0.64
2015 Gautam R, Loughrey JJ, Astashkin AV, Shearer J, Tomat E. Tripyrrindione as a Redox-Active Ligand: Palladium(II) Coordination in Three Redox States. Angewandte Chemie (International Ed. in English). PMID 26448632 DOI: 10.1002/anie.201507302  0.64
2015 Pushie MJ, Shaw K, Franz KJ, Shearer J, Haas KL. Model Peptide Studies Reveal a Mixed Histidine-Methionine Cu(I) Binding Site at the N-Terminus of Human Copper Transporter 1. Inorganic Chemistry. PMID 26258435 DOI: 10.1021/acs.inorgchem.5b01162  0.64
2015 Chen K, Shearer J, Catalano VJ. Subtle Modulation of Cu4X4L2 Phosphine Cluster Cores Leads to Changes in Luminescence. Inorganic Chemistry. PMID 26067759 DOI: 10.1021/acs.inorgchem.5b00443  0.64
2015 Ermert DM, Ghiviriga I, Catalano VJ, Shearer J, Murray LJ. An Air- and Water-Tolerant Zinc Hydride Cluster That Reacts Selectively With CO2. Angewandte Chemie (International Ed. in English). 54: 7047-50. PMID 25914385 DOI: 10.1002/anie.201501539  0.64
2015 Shearer J, Schmitt JC, Clewett HS. Adiabaticity of the proton-coupled electron-transfer step in the reduction of superoxide effected by nickel-containing superoxide dismutase metallopeptide-based mimics. The Journal of Physical Chemistry. B. 119: 5453-61. PMID 25850940 DOI: 10.1021/acs.jpcb.5b02640  0.64
2015 Gan L, Groy TL, Tarakeshwar P, Mazinani SK, Shearer J, Mujica V, Jones AK. A nickel phosphine complex as a fast and efficient hydrogen production catalyst. Journal of the American Chemical Society. 137: 1109-15. PMID 25562523 DOI: 10.1021/ja509779q  0.64
2014 Shearer J, Peck KL, Schmitt JC, Neupane KP. Cysteinate protonation and water hydrogen bonding at the active-site of a nickel superoxide dismutase metallopeptide-based mimic: implications for the mechanism of superoxide reduction. Journal of the American Chemical Society. 136: 16009-22. PMID 25322331 DOI: 10.1021/ja5079514  0.64
2014 Murray LJ, Weare WW, Shearer J, Mitchell AD, Abboud KA. Isolation of a (dinitrogen)tricopper(I) complex. Journal of the American Chemical Society. 136: 13502-5. PMID 25238198 DOI: 10.1021/ja506445d  0.64
2014 Lim SH, Schmitt JC, Shearer J, England KR, Olmstead MM, Balch AL. Formation and structure of two luminescent salts of [Au(SCSN3)2]- obtained through the [2 + 3] cyclization of carbon disulfide and azide ion. Dalton Transactions (Cambridge, England : 2003). 43: 13756-63. PMID 25104505 DOI: 10.1039/c4dt01902d  0.64
2014 Shearer J. Insight into the structure and mechanism of nickel-containing superoxide dismutase derived from peptide-based mimics. Accounts of Chemical Research. 47: 2332-41. PMID 24825124 DOI: 10.1021/ar500060s  0.64
2014 Fitzpatrick J, Kalyvas H, Filipovic MR, Ivanović-Burmazović I, MacDonald JC, Shearer J, Kim E. Transformation of a mononitrosyl iron complex to a [2Fe-2S] cluster by a cysteine analogue. Journal of the American Chemical Society. 136: 7229-32. PMID 24805884 DOI: 10.1021/ja5024207  0.64
2014 Linn D, Kieser J, Shearer J. The novel hydrogen-rich binuclear cobalt complex anion, [(CoH3)2H3](5-). Dalton Transactions (Cambridge, England : 2003). 43: 3412-5. PMID 24394621 DOI: 10.1039/c3dt53117a  0.64
2013 Shearer J. Dioxygen and superoxide stability of metallopeptide based mimics of nickel containing superoxide dismutase: the influence of amine/amidate vs. bis-amidate ligation. Journal of Inorganic Biochemistry. 129: 145-9. PMID 24121677 DOI: 10.1016/j.jinorgbio.2013.09.002  0.64
2013 Bellow JA, Fang D, Kovacevic N, Martin PD, Shearer J, Cisneros GA, Groysman S. Novel alkoxide cluster topologies featuring rare seesaw geometry at transition metal centers. Chemistry (Weinheim An Der Bergstrasse, Germany). 19: 12225-8. PMID 23934604 DOI: 10.1002/chem.201302558  0.64
2013 Fitzpatrick J, Kalyvas H, Shearer J, Kim E. Dioxygen mediated conversion of {Fe(NO)2}9 dinitrosyl iron complexes to Roussin's red esters. Chemical Communications (Cambridge, England). 49: 5550-2. PMID 23675584 DOI: 10.1039/c3cc40352a  0.64
2013 Peck KL, Clewett HS, Schmitt JC, Shearer J. Copper ligation to soluble oligomers of the English mutant of the amyloid-β peptide yields a linear Cu(I) site that is resistant to O2 oxidation. Chemical Communications (Cambridge, England). 49: 4797-9. PMID 23608950 DOI: 10.1039/c3cc40326b  0.64
2013 Dutta A, Flores M, Roy S, Schmitt JC, Hamilton GA, Hartnett HE, Shearer JM, Jones AK. Sequential oxidations of thiolates and the cobalt metallocenter in a synthetic metallopeptide: implications for the biosynthesis of nitrile hydratase. Inorganic Chemistry. 52: 5236-45. PMID 23587023 DOI: 10.1021/ic400171z  0.64
2013 Shearer J. Use of a metallopeptide-based mimic provides evidence for a proton-coupled electron-transfer mechanism for superoxide reduction by nickel-containing superoxide dismutase. Angewandte Chemie (International Ed. in English). 52: 2569-72. PMID 23341243 DOI: 10.1002/anie.201209746  0.64
2013 Lim SH, Schmitt JC, Shearer J, Jia J, Olmstead MM, Fettinger JC, Balch AL. Crystallographic and computational studies of luminescent, binuclear gold(I) complexes, Au(I)2(Ph2P(CH2)nPPh2)2I2 (n = 3-6). Inorganic Chemistry. 52: 823-31. PMID 23302018 DOI: 10.1021/ic301954n  0.64
2012 Coggins MK, Toledo S, Shaffer E, Kaminsky W, Shearer J, Kovacs JA. Characterization and dioxygen reactivity of a new series of coordinatively unsaturated thiolate-ligated manganese(II) complexes. Inorganic Chemistry. 51: 6633-44. PMID 22642272 DOI: 10.1021/ic300192q  0.44
2012 Shearer J, Callan PE, Masitas CA, Grapperhaus CA. Influence of sequential thiolate oxidation on a nitrile hydratase mimic probed by multiedge X-ray absorption spectroscopy. Inorganic Chemistry. 51: 6032-45. PMID 22591049 DOI: 10.1021/ic202453c  0.64
2012 Chen K, Strasser CE, Schmitt JC, Shearer J, Catalano VJ. Modulation of luminescence by subtle anion-cation and anion-π interactions in a trigonal Au(I)···Cu(I) complex. Inorganic Chemistry. 51: 1207-9. PMID 22256886 DOI: 10.1021/ic2023192  0.64
2011 Shakya R, Allard MM, Johann M, Heeg MJ, Rentschler E, Shearer JM, McGarvey B, Verani CN. Modeling the geometric, electronic, and redox properties of iron(III)-containing amphiphiles with asymmetric [NN'O] headgroups. Inorganic Chemistry. 50: 8356-66. PMID 21805957 DOI: 10.1021/ic2009368  0.64
2011 Shearer J, Rosenkoetter KE, Callan PE, Pham C. One octarepeate expansion to the human prion protein alters both the Zn2+ and Cu2+ coordination environments within the octarepeate domain. Inorganic Chemistry. 50: 1173-5. PMID 21250682 DOI: 10.1021/ic102294u  0.64
2011 Tran NG, Kalyvas H, Skodje KM, Hayashi T, Moënne-Loccoz P, Callan PE, Shearer J, Kirschenbaum LJ, Kim E. Phenol nitration induced by an {Fe(NO)2}(10) dinitrosyl iron complex. Journal of the American Chemical Society. 133: 1184-7. PMID 21244001 DOI: 10.1021/ja108313u  0.64
2010 Shearer J, Callan PE, Tran T, Szalai VA. Cu K-edge X-ray absorption spectroscopy reveals differential copper coordination within amyloid-β oligomers compared to amyloid-β monomers. Chemical Communications (Cambridge, England). 46: 9137-9. PMID 21060917 DOI: 10.1039/c0cc02446e  0.64
2010 Shearer J, Callan PE, Amie J. Use of metallopeptide based mimics demonstrates that the metalloprotein nitrile hydratase requires two oxidized cysteinates for catalytic activity. Inorganic Chemistry. 49: 9064-77. PMID 20831172 DOI: 10.1021/ic101765h  0.64
2010 Lesh FD, Shanmugam R, Allard MM, Lanznaster M, Heeg MJ, Rodgers MT, Shearer JM, Verani CN. A modular approach to redox-active multimetallic hydrophobes of discoid topology. Inorganic Chemistry. 49: 7226-8. PMID 20690730 DOI: 10.1021/ic1009626  0.64
2010 Mathrubootham V, Thomas J, Staples R, McCraken J, Shearer J, Hegg EL. Bisamidate and mixed amine/amidate NiN2S2 complexes as models for nickel-containing acetyl coenzyme A synthase and superoxide dismutase: an experimental and computational study. Inorganic Chemistry. 49: 5393-406. PMID 20507077 DOI: 10.1021/ic9023053  0.64
2009 Catalano VJ, Moore AL, Shearer J, Kim J. Luminescent copper(I) halide butterfly dimers coordinated to [Au(CH3imCH2py)2]BF4 and [Au(CH3imCH2quin)2]BF4. Inorganic Chemistry. 48: 11362-75. PMID 19899779 DOI: 10.1021/ic901914n  0.64
2009 Shearer J, Neupane KP, Callan PE. Metallopeptide based mimics with substituted histidines approximate a key hydrogen bonding network in the metalloenzyme nickel superoxide dismutase. Inorganic Chemistry. 48: 10560-71. PMID 19894770 DOI: 10.1021/ic9010407  0.64
2008 Shearer J, Szalai VA. The amyloid-β peptide of Alzheimer's disease binds cu 1 in a linear bis-his coordination environment: Insight into a possible neuroprotective mechanism for the amyloid-β peptide Journal of the American Chemical Society. 130: 17826-17835. PMID 19035781 DOI: 10.1021/ja805940m  0.64
2008 Lugo-Mas P, Taylor W, Schweitzer D, Theisen RM, Xu L, Shearer J, Swartz RD, Gleaves MC, Dipasquale A, Kaminsky W, Kovacs JA. Properties of square-pyramidal alkyl-thiolate Fe(III) complexes, including an analogue of the unmodified form of nitrile hydratase. Inorganic Chemistry. 47: 11228-36. PMID 18989922 DOI: 10.1021/ic801704n  0.64
2008 Shearer J, Soh P, Lentz S. Both Met(109) and Met(112) are utilized for Cu(II) coordination by the amyloidogenic fragment of the human prion protein at physiological pH Journal of Inorganic Biochemistry. 102: 2103-2113. PMID 18778855 DOI: 10.1016/j.jinorgbio.2008.07.016  0.64
2008 Dupont CL, Neupane K, Shearer J, Palenik B. Diversity, function and evolution of genes coding for putative Ni-containing superoxide dismutases. Environmental Microbiology. 10: 1831-43. PMID 18412551 DOI: 10.1111/j.1462-2920.2008.01604.x  0.64
2008 Shearer J, Dehestani A, Abanda F. Probing variable amine/amide ligation in Ni(II)N2S2 complexes using sulfur K-edge and nickel L-edge X-ray absorption spectroscopies: implications for the active site of nickel superoxide dismutase. Inorganic Chemistry. 47: 2649-60. PMID 18330983 DOI: 10.1021/ic7019878  0.64
2008 Shearer J. Influence of sequential guanidinium methylation on the energetics of tye guanidinium guanine dimer and guanidinium guanine cytosine trimer implications for the control of protein DNA interactions by arginine methyltransferases Journal of Physical Chemistry B. 112: 16995-17002. DOI: 10.1021/jp808288p  0.64
2007 Neupane KP, Gearty K, Francis A, Shearer J. Probing variable axial ligation in nickel superoxide dismutase utilizing metallopeptide-based models: insight into the superoxide disproportionation mechanism. Journal of the American Chemical Society. 129: 14605-18. PMID 17985883 DOI: 10.1021/ja0731625  0.64
2007 Brines LM, Shearer J, Fender JK, Schweitzer D, Shoner SC, Barnhart D, Kaminsky W, Lovell S, Kovacs JA. Periodic trends within a series of five-coordinate thiolate-ligated [MII(SMe2N4(tren))]+ (M = Mn, Fe, Co, Ni, Cu, Zn) complexes, including a rare example of a stable CuII-thiolate. Inorganic Chemistry. 46: 9267-77. PMID 17867686 DOI: 10.1021/ic701433p  0.64
2007 Shearer J, Soh P. The copper(II) adduct of the unstructured region of the amyloidogenic fragment derived from the human prion protein is redox-active at physiological pH Inorganic Chemistry. 46: 710-719. PMID 17257012 DOI: 10.1021/ic061236s  0.64
2007 Shearer J, Soh P. Ni K-edge XAS suggests that coordination of NiII to the unstructured amyloidogenic region of the human prion protein produces a Ni2 bis-μ-hydroxo dimer Journal of Inorganic Biochemistry. 101: 370-373. PMID 17126907 DOI: 10.1016/j.jinorgbio.2006.09.032  0.64
2006 Neupane KP, Shearer J. The influence of amine/amide versus bisamide coordination in nickel superoxide dismutase. Inorganic Chemistry. 45: 10552-66. PMID 17173410 DOI: 10.1021/ic061156o  0.64
2006 Shearer J, Zhao N. [Me4N](NiII(BEAAM)): A synthetic model for nickel superoxide dismutase that contains Ni in a mixed amine/amide coordination environment Inorganic Chemistry. 45: 9637-9639. PMID 17112256 DOI: 10.1021/ic061604s  0.64
2006 Frost BJ, Bautista CM, Huang R, Shearer J. Manganese complexes of 1,3,5-triaza-7-phosphaadamantane (PTA): the first nitrogen-bound transition-metal complex of PTA. Inorganic Chemistry. 45: 3481-3. PMID 16634574 DOI: 10.1021/ic060322p  0.64
2006 Shearer J, Long LM. A nickel superoxide dismutase maquette that reproduces the spectroscopic and functional properties of the metalloenzyme Inorganic Chemistry. 45: 2358-2360. PMID 16529443 DOI: 10.1021/ic0514344  0.64
2006 Frost BJ, Miller SB, Rove KO, Pearson DM, Korinek JD, Harkreader JL, Mebi CA, Shearer J. Synthesis, characterization, and crystal structure of a quadruply bonded dimolybdenum(II) complex containing the water-soluble phosphine 1,3,5-triaza-7-phosphaadamantane (PTA) Inorganica Chimica Acta. 359: 283-288. DOI: 10.1016/j.ica.2005.10.007  0.64
2005 Shearer J, Zhang CX, Zakharov LN, Rheingold AL, Karlin KD. Substrate oxidation by copper-dioxygen adducts: mechanistic considerations. Journal of the American Chemical Society. 127: 5469-83. PMID 15826184 DOI: 10.1021/ja045191a  0.64
2004 Theisen RM, Shearer J, Kaminsky W, Kovacs JA. Steric and electronic control over the reactivity of a thiolate-ligated Fe(II) complex with dioxygen and superoxide: reversible mu-oxo dimer formation. Inorganic Chemistry. 43: 7682-90. PMID 15554633 DOI: 10.1021/ic0491884  0.64
2004 Kim E, Shearer J, Lu S, Moënne-Loccoz P, Helton ME, Kaderli S, Zuberbühler AD, Karlin KD. Heme/Cu/O2 reactivity: change in FeIII-(O2 2-)-CuII unit peroxo binding geometry effected by tridentate copper chelation. Journal of the American Chemical Society. 126: 12716-7. PMID 15469233 DOI: 10.1021/ja045941g  0.64
2003 Shearer J, Zhang CX, Hatcher LQ, Karlin KD. Distinguishing rate-limiting electron versus H-atom transfers in Cu2O2-mediated oxidative N-dealkylations: application of inter- versus intramolecular kinetic isotope effects. Journal of the American Chemical Society. 125: 12670-1. PMID 14558790 DOI: 10.1021/ja0359409  0.64
2003 Shearer J, Kaminsky W, Kovacs JA. A chloride ion contained in a cobalt 'claw': [Co3(DADIT)3]Cl(PF6)2. Acta Crystallographica. Section C, Crystal Structure Communications. 59: m379-80. PMID 12944651  0.44
2003 Shearer J, Fitch SB, Kaminsky W, Benedict J, Scarrow RC, Kovacs JA. How does cyanide inhibit superoxide reductase? Insight from synthetic FeIIIN4S model complexes. Proceedings of the National Academy of Sciences of the United States of America. 100: 3671-6. PMID 12655068 DOI: 10.1073/pnas.0637029100  0.64
2003 Zhang CX, Liang HC, Kim EI, Shearer J, Helton ME, Kim E, Kaderli S, Incarvito CD, Zuberbühler AD, Rheingold AL, Karlin KD. Tuning copper-dioxygen reactivity and exogenous substrate oxidations via alterations in ligand electronics. Journal of the American Chemical Society. 125: 634-5. PMID 12526654 DOI: 10.1021/ja028779v  0.64
2002 Shearer J, Scarrow RC, Kovacs JA. Synthetic models for the cysteinate-ligated non-heme iron enzyme superoxide reductase: observation and structural characterization by XAS of an Fe(III)-OOH intermediate. Journal of the American Chemical Society. 124: 11709-17. PMID 12296737  0.44
2002 Shearer J, Jackson HL, Schweitzer D, Rittenberg DK, Leavy TM, Kaminsky W, Scarrow RC, Kovacs JA. The first example of a nitrile hydratase model complex that reversibly binds nitriles. Journal of the American Chemical Society. 124: 11417-28. PMID 12236756 DOI: 10.1021/ja012555f  0.64
2002 Schweitzer D, Shearer J, Rittenberg DK, Shoner SC, Ellison JJ, Loloee R, Lovell S, Barnhart D, Kovacs JA. Enhancing reactivity via structural distortion. Inorganic Chemistry. 41: 3128-36. PMID 12054991 DOI: 10.1021/ic0109187  0.64
2002 Shearer J, Lai J, Jacobs DL, Kovacs JA. Preparation and properties of [NiII(BEES)(Cl)](BPh4): A NiII complex in a mixed nitrogen/thioether coordination environment Inorganica Chimica Acta. 336: 61-64. DOI: 10.1016/S0020-1693(02)00878-2  0.64
2001 Shearer J, Nehring J, Lovell S, Kaminsky W, Kovacs JA. Modeling the reactivity of superoxide reducing metalloenzymes with a nitrogen and sulfur coordinated iron complex Inorganic Chemistry. 40: 5483-5484. PMID 11599942 DOI: 10.1021/ic010221l  0.64
2001 Dooley PA, Tsarouhtsis D, Korbel GA, Nechev LV, Shearer J, Zegar IS, Harris CM, Stone MP, Harris TM. Structural studies of an oligodeoxynucleotide containing a trimethylene interstrand cross-link in a 5'-(CpG) motif: model of a malondialdehyde cross-link. Journal of the American Chemical Society. 123: 1730-9. PMID 11456774 DOI: 10.1021/ja003163w  0.64
2001 Shearer J, Kung IY, Lovell S, Kaminsky W, Kovacs JA. Why is there an "inert" metal center in the active site of nitrile hydratase? Reactivity and ligand dissociation from a five-coordinate Co(III) nitrile hydratase model Journal of the American Chemical Society. 123: 463-468. PMID 11456548 DOI: 10.1021/ja002642s  0.64
2000 Shearer J, Kung IY, Lovell S, Kovacs JA. A Co(III) complex in a mixed sulfur/nitrogen ligand environment: Modeling the substrate- and product-bound forms of the metalloenzyme thiocyanate hydrolase Inorganic Chemistry. 39: 4998-4999. PMID 11233193 DOI: 10.1021/ic0005689  0.64
2000 Zhou X, Shearer J, Rokita SE. A Ni(salen)-biotin conjugate for rapid isolation of accessible DNA [11] Journal of the American Chemical Society. 122: 9046-9047. DOI: 10.1021/ja0018670  0.64
2000 Kung I, Schweitzer D, Shearer J, Taylor WD, Jackson HL, Lovell S, Kovacs JA. How do oxidized thiolate ligands affect the electronic and reactivity properties of a nitrile hydratase model compound? [1] Journal of the American Chemical Society. 122: 8299-8300. DOI: 10.1021/ja0017561  0.64
1999 Shearer JM, Rokita SE. Diamine preparation for synthesis of a water soluble Ni(II) salen complex. Bioorganic & Medicinal Chemistry Letters. 9: 501-4. PMID 10091710 DOI: 10.1016/S0960-894X(99)00020-7  0.64
1999 Pande P, Shearer J, Yang J, Greenberg WA, Rokita SE. Alkylation of nucleic acids by a model quinone methide Journal of the American Chemical Society. 121: 6773-6779. DOI: 10.1021/ja990456k  0.64
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