Jean Zhao, Ph.D. - Related publications

Biological Chemistry and Molecular Pharmacology Harvard Medical School, Boston, MA, United States 
PI3K, malignant transformation
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Hua H, Zhang H, Chen J, Wang J, Liu J, Jiang Y. Targeting Akt in cancer for precision therapy. Journal of Hematology & Oncology. 14: 128. PMID 34419139 DOI: 10.1186/s13045-021-01137-8   
2021 Brägelmann J, Lorenz C, Borchmann S, Nishii K, Wegner J, Meder L, Ostendorp J, Ast DF, Heimsoeth A, Nakasuka T, Hirabae A, Okawa S, Dammert MA, Plenker D, Klein S, et al. MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I. Nature Communications. 12: 5505. PMID 34535668 DOI: 10.1038/s41467-021-25728-8   
2021 Wu SY, Lin KC, Lawal B, Wu ATH, Wu CZ. MXD3 as an onco-immunological biomarker encompassing the tumor microenvironment, disease staging, prognoses, and therapeutic responses in multiple cancer types. Computational and Structural Biotechnology Journal. 19: 4970-4983. PMID 34584637 DOI: 10.1016/j.csbj.2021.08.047   
2021 Uhlitz F, Bischoff P, Peidli S, Sieber A, Trinks A, Lüthen M, Obermayer B, Blanc E, Ruchiy Y, Sell T, Mamlouk S, Arsie R, Wei TT, Klotz-Noack K, Schwarz RF, et al. Mitogen-activated protein kinase activity drives cell trajectories in colorectal cancer. Embo Molecular Medicine. e14123. PMID 34409732 DOI: 10.15252/emmm.202114123   
2021 Castro J, Tornillo G, Ceada G, Ramos-Neble B, Bravo M, Ribó M, Vilanova M, Smalley MJ, Benito A. A Nuclear-Directed Ribonuclease Variant Targets Cancer Stem Cells and Inhibits Migration and Invasion of Breast Cancer Cells. Cancers. 13. PMID 34503160 DOI: 10.3390/cancers13174350   
2021 Ha J, Lee S, Park J, Seo J, Kang E, Yoon H, Kim BR, Lee HK, Ryu SE, Cho S. Identification of a novel inhibitor of liver cancer cell invasion and proliferation through regulation of Akt and Twist1. Scientific Reports. 11: 16765. PMID 34408201 DOI: 10.1038/s41598-021-95933-4   
2021 Melo CM, Vidotto T, Chaves LP, Lautert-Dutra W, Reis RBD, Squire JA. The Role of Somatic Mutations on the Immune Response of the Tumor Microenvironment in Prostate Cancer. International Journal of Molecular Sciences. 22. PMID 34502458 DOI: 10.3390/ijms22179550   
2021 Ding X, Chen T, Shi Q, Nan P, Wang X, Xie D, Li J. INTS6 promotes colorectal cancer progression by activating of AKT and ERK signaling. Experimental Cell Research. 112826. PMID 34508742 DOI: 10.1016/j.yexcr.2021.112826   
2021 Neophytou CM, Trougakos IP, Erin N, Papageorgis P. Apoptosis Deregulation and the Development of Cancer Multi-Drug Resistance. Cancers. 13. PMID 34503172 DOI: 10.3390/cancers13174363   
2021 Zhang H, Kong L, Zhang Y, Wang C, Sun L. Transcriptome and proteome analysis of the antitumor activity of maslinic acid against pancreatic cancer cells. Aging. 13. PMID 34637398 DOI: 10.18632/aging.203623   
2021 Wang W, Yin Q, Guo S, Wang J. contributes toward the carcinogenesis of liver cancer and regulates PI3K/Akt/mTOR signaling. Experimental and Therapeutic Medicine. 22: 1053. PMID 34434267 DOI: 10.3892/etm.2021.10487   
2021 Wang SP, Hsu YP, Chang CJ, Chan YC, Chen CH, Wang RH, Liu KK, Pan PY, Wu YH, Yang CM, Chen C, Yang JM, Liang MC, Wong KK, Chao JI. A novel EGFR inhibitor suppresses survivin expression and tumor growth in human gefitinib-resistant EGFR-wild type and -T790M non-small cell lung cancer. Biochemical Pharmacology. 114792. PMID 34597670 DOI: 10.1016/j.bcp.2021.114792   
2021 Sato A, Rahman NIA, Shimizu A, Ogita H. Cell-to-cell contact-mediated regulation of tumor behavior in the tumor microenvironment. Cancer Science. PMID 34420253 DOI: 10.1111/cas.15114   
2021 Song L, Qi S, Hu W, Fang Z, Yu D, Liu T, Wu J, Wu Y, Wu A, Feng L, Xie J, Zhang B, He W, Ning Z, Liu L, et al. Integrative analysis reveals clinically relevant molecular fingerprints in pancreatic cancer. Molecular Therapy. Nucleic Acids. 26: 11-21. PMID 34513290 DOI: 10.1016/j.omtn.2021.06.015   
2021 Buechel D, Sugiyama N, Rubinstein N, Saxena M, Kalathur RKR, Lüönd F, Vafaizadeh V, Valenta T, Hausmann G, Cantù C, Basler K, Christofori G. Parsing β-catenin's cell adhesion and Wnt signaling functions in malignant mammary tumor progression. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34408016 DOI: 10.1073/pnas.2020227118   
2021 Huang R, Chen H, Liang J, Li Y, Yang J, Luo C, Tang Y, Ding Y, Liu X, Yuan Q, Yu H, Ye Y, Xu W, Xie X. Dual Role of Reactive Oxygen Species and their Application in Cancer Therapy. Journal of Cancer. 12: 5543-5561. PMID 34405016 DOI: 10.7150/jca.54699   
2021 Qiao Q, Bai R, Song W, Gao H, Zhang M, Lu J, Hong M, Zhang X, Sun P, Zhang Q, Zhao P. Human α-Defensin 5 suppressed Colon Cancer Growth by Targeting PI3K pathway. Experimental Cell Research. 112809. PMID 34487729 DOI: 10.1016/j.yexcr.2021.112809   
2021 Liu J, Tian Z, Liu T, Wen D, Ma Z, Liu Y, Zhu J. CHSY1 is upregulated and acts as tumor promotor in gastric cancer through regulating cell proliferation, apoptosis, and migration. Cell Cycle (Georgetown, Tex.). 1-14. PMID 34412565 DOI: 10.1080/15384101.2021.1963553   
2021 Bhardwaj N, Tripathi N, Goel B, Jain SK. Anticancer Activity of Diosgenin and its Semi-synthetic Derivatives: Role in Autophagy Mediated Cell Death and Induction of Apoptosis. Mini Reviews in Medicinal Chemistry. PMID 33402081 DOI: 10.2174/1389557521666210105111224   
2021 Duan Y, Chen L, Shao J, Jiang C, Zhao Y, Li Y, Ke H, Zhang R, Zhu J, Yu M. Lanatoside C inhibits human cervical cancer cell proliferation and induces cell apoptosis by a reduction of the JAK2/STAT6/SOCS2 signaling pathway. Oncology Letters. 22: 740. PMID 34466152 DOI: 10.3892/ol.2021.13001   
2021 Zhu H, Hu X, Ye Y, Jian Z, Zhong Y, Gu L, Xiong X. Pan-Cancer Analysis of PIMREG as a Biomarker for the Prognostic and Immunological Role. Frontiers in Genetics. 12: 687778. PMID 34594356 DOI: 10.3389/fgene.2021.687778   
2021 Ashrafizadeh M, Zarrabi A, Mirzaei S, Hashemi F, Samarghandian S, Zabolian A, Hushmandi K, Ang HL, Sethi G, Kumar AP, Ahn KS, Nabavi N, Khan H, Makvandi P, Varma RS. Use of Gallic acid for cancer treatment: Molecular mechanisms and improvement of efficacy by nanoformulations. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 112576. PMID 34571052 DOI: 10.1016/j.fct.2021.112576   
2021 Li M, Li X, Goldsmith JR, Shi S, Zhang L, Zamani A, Wan L, Sun H, Li T, Yu J, Etwebi Z, Bou-Dargham MJ, Chen YH. Decoupling tumor cell metastasis from growth by cellular pilot protein TNFAIP8. Oncogene. PMID 34608264 DOI: 10.1038/s41388-021-02035-6   
2021 Lawal B, Tseng SH, Olugbodi JO, Iamsaard S, Ilesanmi OB, Mahmoud MH, Ahmed SH, Batiha GE, Wu ATH. Pan-Cancer Analysis of Immune Complement Signature C3/C5/C3AR1/C5AR1 in Association with Tumor Immune Evasion and Therapy Resistance. Cancers. 13. PMID 34439277 DOI: 10.3390/cancers13164124   
2021 Barcus CE, Hwang PY, Morikis V, Brenot A, Pence P, Clarke M, Longmore GD. Tyrosine kinase independent actions of DDR2 in tumor cells and CAFs influence tumor invasion, migration, and metastasis. Journal of Cell Science. PMID 34477203 DOI: 10.1242/jcs.258431   
2021 Sun Y, Xie J, Cai S, Wang Q, Feng Z, Li Y, Lu JJ, Chen W, Ye Z. Elevated expression of nuclear receptor-binding SET domain 3 promotes pancreatic cancer cell growth. Cell Death & Disease. 12: 913. PMID 34615858 DOI: 10.1038/s41419-021-04205-6   
2021 Chen L, Ren LQ, Liu Z, Liu X, Tu H, Huang XY. Bio-informatics and Experiments Reveal the Mechanism of Schisandrin A Against MDA-MB-231 cells. Bioengineered. PMID 34550868 DOI: 10.1080/21655979.2021.1982307   
2021 Tavares FM, Gomes AC, Assunção EM, de Medeiros JLS, Scotti MT, Scotti L, Ishiki HM. Virtual Screening and Molecular Docking: Discovering Novel c-KIT Inhibitors. Current Medicinal Chemistry. PMID 34525909 DOI: 10.2174/0929867328666210915102920   
2021 Jeong MS, Lee KW, Choi YJ, Kim YG, Hwang HH, Lee SY, Jung SE, Park SA, Lee JH, Joo YJ, Cho SG, Ko SG. Synergistic Antitumor Activity of SH003 and Docetaxel via EGFR Signaling Inhibition in Non-Small Cell Lung Cancer. International Journal of Molecular Sciences. 22. PMID 34445110 DOI: 10.3390/ijms22168405   
2021 Chen Y, Zhang Z, Henson ES, Cuddihy A, Haigh K, Wang R, Haigh JJ, Gibson SB. Autophagy inhibition by TSSC4 (tumor suppressing subtransferable candidate 4) contributes to sustainable cancer cell growth. Autophagy. 1-23. PMID 34530675 DOI: 10.1080/15548627.2021.1973338   
2021 Davoodvandi A, Farshadi M, Zare N, Akhlagh SA, Alipour Nosrani E, Mahjoubin-Tehran M, Kangari P, Sharafi SM, Khan H, Aschner M, Baniebrahimi G, Mirzaei H. Antimetastatic Effects of Curcumin in Oral and Gastrointestinal Cancers. Frontiers in Pharmacology. 12: 668567. PMID 34456716 DOI: 10.3389/fphar.2021.668567   
2021 Song KW, Edgar KA, Hanan EJ, Hafner M, Oeh J, Merchant M, Sampath D, Nannini MA, Hong R, Phu L, Forrest WF, Stawiski E, Schmidt S, Endres N, Guan J, et al. RTK-dependent inducible degradation of mutant PI3Kα drives GDC-0077 (Inavolisib) efficacy. Cancer Discovery. PMID 34544753 DOI: 10.1158/2159-8290.CD-21-0072   
2021 Wang K, Zhong H, Li N, Yu N, Wang Y, Chen L, Sun J. Discovery of Novel Anti-Breast-Cancer Inhibitors by Synergistically Antagonizing Microtubule Polymerization and Aryl Hydrocarbon Receptor Expression. Journal of Medicinal Chemistry. PMID 34428056 DOI: 10.1021/acs.jmedchem.1c01099   
2021 Xu Y, Xu W, Lu Z, Cheung MH, Lin M, Liang C, Lou J, Chen Y. Anti-Gastric Cancer Effect of Purified Protein via Regulating the JAK/STAT3 Signaling Pathway. Nutrition and Cancer. 1-12. PMID 34601984 DOI: 10.1080/01635581.2021.1960385   
2021 Wei H, Ge Q, Zhang LY, Xie J, Gan RH, Lu YG, Zheng DL. EGCG inhibits growth of tumoral lesions on lip and tongue of K-Ras transgenic mice through the Notch pathway. The Journal of Nutritional Biochemistry. 108843. PMID 34407449 DOI: 10.1016/j.jnutbio.2021.108843   
2021 He X, Yao Q, Hall DD, Song Z, Fan D, You Y, Lian W, Zhou Z, Duan L, Chen B. Levofloxacin exerts broad-spectrum anticancer activity via regulation of THBS1, LAPTM5, SRD5A3, MFAP5 and P4HA1. Anti-Cancer Drugs. PMID 34419964 DOI: 10.1097/CAD.0000000000001194   
2021 Kadry YA, Lee JY, Witze ES. Regulation of EGFR signalling by palmitoylation and its role in tumorigenesis. Open Biology. 11: 210033. PMID 34610265 DOI: 10.1098/rsob.210033   
2021 Jiang M, Chu Y, Yang T, Li W, Zhang Z, Sun H, Liang H, Yang F. Developing a Novel Indium(III) Agent Based on Liposomes to Overcome Cisplatin-Induced Resistance in Breast Cancer by Multitargeting the Tumor Microenvironment Components. Journal of Medicinal Chemistry. PMID 34609868 DOI: 10.1021/acs.jmedchem.1c01068   
2021 Stubbs CK, Biancucci M, Vidimar V, Satchell KJF. RAS specific protease induces irreversible growth arrest via p27 in several KRAS mutant colorectal cancer cell lines. Scientific Reports. 11: 17925. PMID 34504197 DOI: 10.1038/s41598-021-97422-0   
2021 Mehraj U, Ganai RA, Macha MA, Hamid A, Zargar MA, Bhat AA, Nasser MW, Haris M, Batra SK, Alshehri B, Al-Baradie RS, Mir MA, Wani NA. The tumor microenvironment as driver of stemness and therapeutic resistance in breast cancer: New challenges and therapeutic opportunities. Cellular Oncology (Dordrecht). PMID 34528143 DOI: 10.1007/s13402-021-00634-9   
2021 Huang TH, Mokgautsi N, Huang YJ, Wu ATH, Huang HS. Comprehensive Omics Analysis of a Novel Small-Molecule Inhibitor of Chemoresistant Oncogenic Signatures in Colorectal Cancer Cell with Antitumor Effects. Cells. 10. PMID 34440739 DOI: 10.3390/cells10081970   
2021 Mukha A, Kahya U, Dubrovska A. Targeting glutamine metabolism and autophagy: the combination for prostate cancer radiosensitization. Autophagy. 1-3. PMID 34486482 DOI: 10.1080/15548627.2021.1962682   
2021 Sakuma S, Raices M, Borlido J, Guglielmi V, Zhu EYS, D'Angelo MA. Inhibition of Nuclear Pore Complex Formation Selectively Induces Cancer Cell Death. Cancer Discovery. 11: 176-193. PMID 32988961 DOI: 10.1158/2159-8290.CD-20-0581   
2021 Qiu H, Shao Z, Wen X, Jiang J, Ma Q, Wang Y, Huang L, Ding X, Zhang L. TREM2: Keeping Pace With Immune Checkpoint Inhibitors in Cancer Immunotherapy. Frontiers in Immunology. 12: 716710. PMID 34539652 DOI: 10.3389/fimmu.2021.716710   
2021 Yan Y, Zhang Y, Li M, Zhang Y, Zhang X, Zhang X, Xu Y, Wei W, Wang J, Xu X, Song Q, Zhao C. C644-0303, A Small Molecule Inhibitor of Wnt/β-catenin Pathway, Suppresses Colorectal Cancer Growth. Cancer Science. PMID 34431598 DOI: 10.1111/cas.15118   
2021 Su X, Xu Y, Fox GC, Xiang J, Kwakwa KA, Davis JL, Belle JI, Lee WC, Wong WH, Fontana F, Hernandez-Aya L, Kobayashi T, Tomasson HM, Su J, Bakewell SJ, et al. Breast cancer derived GM-CSF regulates arginase 1 in myeloid cells to promote an immunosuppressive microenvironment. The Journal of Clinical Investigation. PMID 34520398 DOI: 10.1172/JCI145296   
2021 Lin X, Han T, Xia Q, Cui J, Zhuo M, Liang Y, Su W, Wang L, Wang L, Liu Z, Xiao X. CHPF promotes gastric cancer tumorigenesis through the activation of E2F1. Cell Death & Disease. 12: 876. PMID 34564711 DOI: 10.1038/s41419-021-04148-y   
2021 Fu X, Li M, Tang C, Huang Z, Najafi M. Targeting of cancer cell death mechanisms by resveratrol: a review. Apoptosis : An International Journal On Programmed Cell Death. PMID 34561763 DOI: 10.1007/s10495-021-01689-7   
2021 Yan Y, Liang Q, Xu Z, Yi Q. Integrative bioinformatics and experimental analysis revealed down-regulated CDC42EP3 as a novel prognostic target for ovarian cancer and its roles in immune infiltration. Peerj. 9: e12171. PMID 34616622 DOI: 10.7717/peerj.12171   
2021 Yu C, Yang B, Najafi M. Targeting of cancer cell death mechanisms by curcumin; implications to cancer therapy. Basic & Clinical Pharmacology & Toxicology. PMID 34473898 DOI: 10.1111/bcpt.13648