| Year |
Citation |
Score |
| 2019 |
McBride JW, Malcolm RK, Dias N, Cameron D, Offord RE, Hartley O, Kett VL, Devlin B, Boyd P. Development and pharmacokinetics of a combination vaginal ring for sustained release of dapivirine and the protein microbicide 5P12-RANTES. International Journal of Pharmaceutics. 564: 207-213. PMID 30999049 DOI: 10.1016/J.Ijpharm.2019.04.040 |
0.314 |
|
| 2019 |
McBride JW, Boyd P, Dias N, Cameron D, Offord RE, Hartley O, Kett VL, Malcolm RK. Vaginal rings with exposed cores for sustained delivery of the HIV CCR5 inhibitor 5P12-RANTES. Journal of Controlled Release : Official Journal of the Controlled Release Society. 298: 1-11. PMID 30731150 DOI: 10.1016/J.Jconrel.2019.02.003 |
0.337 |
|
| 2017 |
Cerini F, Offord RE, McGowan I, Hartley O. Stability of 5P12-RANTES, a candidate rectal microbicide, in human rectal lavage. Aids Research and Human Retroviruses. PMID 28177261 DOI: 10.1089/Aid.2016.0199 |
0.357 |
|
| 2015 |
Cerini F, Gaertner H, Madden K, Tolstorukov I, Brown S, Laukens B, Callewaert N, Harner JC, Oommen AM, Harms JT, Sump AR, Sealock RC, Peterson DJ, Johnson SK, Abramson SB, ... ... Offord R, et al. A scalable low-cost cGMP process for clinical grade production of the HIV inhibitor 5P12-RANTES in Pichia pastoris. Protein Expression and Purification. PMID 26506568 DOI: 10.1016/J.Pep.2015.10.011 |
0.344 |
|
| 2012 |
Choi WT, Nedellec R, Coetzer M, Colin P, Lagane B, Offord RE, Hartley O, Mosier DE. CCR5 mutations distinguish N-terminal modifications of RANTES (CCL5) with agonist versus antagonist activity. Journal of Virology. 86: 10218-20. PMID 22787219 DOI: 10.1128/Jvi.00353-12 |
0.324 |
|
| 2011 |
Pilch-Cooper HA, Sieg SF, Hope TJ, Koons A, Escola JM, Offord R, Veazey RS, Mosier DE, Clagett B, Medvik K, Jadlowsky JK, Chance MR, Kiselar JG, Hoxie JA, Collman RG, et al. Circulating human CD4 and CD8 T cells do not have large intracellular pools of CCR5. Blood. 118: 1015-9. PMID 21068438 DOI: 10.1182/Blood-2010-05-282509 |
0.309 |
|
| 2010 |
Nedellec R, Coetzer M, Lederman MM, Offord RE, Hartley O, Mosier DE. "Resistance" to PSC-RANTES revisited: two mutations in human immunodeficiency virus type 1 HIV-1 SF162 or simian-human immunodeficiency virus SHIV SF162-p3 do not confer resistance. Journal of Virology. 84: 5842-5. PMID 20335248 DOI: 10.1128/Jvi.01907-09 |
0.328 |
|
| 2009 |
Veazey RS, Ling B, Green LC, Ribka EP, Lifson JD, Piatak M, Lederman MM, Mosier D, Offord R, Hartley O. Topically applied recombinant chemokine analogues fully protect macaques from vaginal simian-human immunodeficiency virus challenge. The Journal of Infectious Diseases. 199: 1525-7. PMID 19331577 DOI: 10.1086/598685 |
0.331 |
|
| 2008 |
Gaertner HF, Cerini F, Escola J, Kuenzi G, Melotti A, Offord RE, Rossitto-Borlat I, Nedellec R, Salkowitz J, Gorochov G, Mosier D, Hartley O. Highly potent, fully recombinant anti-HIV chemokines: reengineering a low-cost microbicide. Proceedings of the National Academy of Sciences of the United States of America. 105: 17706-17711. PMID 19004761 DOI: 10.1073/Pnas.0805098105 |
0.388 |
|
| 2008 |
Cerini F, Landay A, Gichinga C, Lederman MM, Flyckt R, Starks D, Offord RE, Le Gal F, Hartley O. Chemokine analogues show suitable stability for development as microbicides. Journal of Acquired Immune Deficiency Syndromes (1999). 49: 472-6. PMID 18989226 DOI: 10.1097/Qai.0B013E31818C953F |
0.348 |
|
| 2008 |
Gaertner HF, Offord RE, Botti P, Kuenzi G, Hartley O. Semisynthetic analogues of PSC-RANTES, a potent anti-HIV protein. Bioconjugate Chemistry. 19: 480-489. PMID 18179159 DOI: 10.1021/Bc7003044 |
0.422 |
|
| 2008 |
Gaertner H, Lebeau O, Borlat I, Cerini F, Dufour B, Kuenzi G, Melotti A, Fish RJ, Offord R, Springael JY, Parmentier M, Hartley O. Highly potent HIV inhibition: engineering a key anti-HIV structure from PSC-RANTES into MIP-1 beta/CCL4. Protein Engineering, Design & Selection : Peds. 21: 65-72. PMID 18178567 DOI: 10.1093/Protein/Gzm079 |
0.351 |
|
| 2006 |
Lederman MM, Offord RE, Hartley O. Microbicides and other topical strategies to prevent vaginal transmission of HIV. Nature Reviews. Immunology. 6: 371-82. PMID 16639430 DOI: 10.1038/Nri1848 |
0.312 |
|
| 2005 |
Hartley O, Offord RE. Engineering chemokines to develop optimized HIV inhibitors. Current Protein & Peptide Science. 6: 207-19. PMID 15974948 DOI: 10.2174/1389203054065400 |
0.359 |
|
| 2004 |
Hartley O, Gaertner H, Wilken J, Thompson D, Fish R, Ramos A, Pastore C, Dufour B, Cerini F, Melotti A, Heveker N, Picard L, Alizon M, Mosier D, Kent S, ... Offord R, et al. Medicinal chemistry applied to a synthetic protein: Development of highly potent HIV entry inhibitors Proceedings of the National Academy of Sciences of the United States of America. 101: 16460-16465. PMID 15545608 DOI: 10.1073/Pnas.0404802101 |
0.376 |
|
| 2004 |
Lederman MM, Veazey RS, Offord RE, Mosier DE, Dufour J, Mefford M, Piatak M, Lifson JD, Salkowitz JR, Rodriguez B, Blauvelt A, Hartley O. Prevention of Vaginal SHIV Transmission in Rhesus Macaques Through Inhibition of CCR5 Science. 306: 485-487. PMID 15486300 DOI: 10.1126/Science.1099288 |
0.356 |
|
| 2004 |
Kawamura T, Bruse SE, Abraha A, Sugaya M, Hartley O, Offord RE, Arts EJ, Zimmerman PA, Blauvelt A, Bruce SE. PSC-RANTES blocks R5 human immunodeficiency virus infection of Langerhans cells isolated from individuals with a variety of CCR5 diplotypes. Journal of Virology. 78: 7602-9. PMID 15220435 DOI: 10.1128/Jvi.78.14.7602-7609.2004 |
0.346 |
|
| 2003 |
Hartley O, Dorgham K, Perez-Bercoff D, Cerini F, Heimann A, Gaertner H, Offord RE, Pancino G, Debré P, Gorochov G. Human immunodeficiency virus type 1 entry inhibitors selected on living cells from a library of phage chemokines. Journal of Virology. 77: 6637-44. PMID 12767983 DOI: 10.1128/Jvi.77.12.6637-6644.2003 |
0.353 |
|
| 2003 |
Chen J, Zeng W, Offord R, Rose K. A novel method for the rational construction of well-defined immunogens: the use of oximation to conjugate cholera toxin B subunit to a peptide-polyoxime complex. Bioconjugate Chemistry. 14: 614-618. PMID 12757387 DOI: 10.1021/Bc025651U |
0.338 |
|
| 2003 |
Pastore C, Picchio GR, Galimi F, Fish R, Hartley O, Offord RE, Mosier DE. Two mechanisms for human immunodeficiency virus type 1 inhibition by N-terminal modifications of RANTES. Antimicrobial Agents and Chemotherapy. 47: 509-17. PMID 12543651 DOI: 10.1128/Aac.47.2.509-517.2003 |
0.397 |
|
| 2001 |
Marozsan AJ, Torre VS, Johnson M, Ball SC, Cross JV, Templeton DJ, Quiñones-Mateu ME, Offord RE, Arts EJ. Mechanisms involved in stimulation of human immunodeficiency virus type 1 replication by aminooxypentane RANTES. Journal of Virology. 75: 8624-38. PMID 11507208 DOI: 10.1128/Jvi.75.18.8624-8638.2001 |
0.349 |
|
| 2001 |
Sabbe R, Picchio GR, Pastore C, Chaloin O, Hartley O, Offord RE, Mosier DE. Donor- and Ligand-Dependent Differences in C-C Chemokine Receptor 5 Reexpression Journal of Virology. 75: 661-671. PMID 11134280 DOI: 10.1128/Jvi.75.2.661-671.2001 |
0.374 |
|
| 2001 |
Lederman M, Mosier D, Arts E, Letvin N, Flexner C, Blauvelt A, Cairns S, Bridges S, Sarver N, Offord R. Rationale for testing chemokine inhibitors (Virustats) for prevention of HIV-1 transmission. Aids. 15: S57-S58. DOI: 10.1097/00002030-200102001-00081 |
0.314 |
|
| 2000 |
Kawamura T, Cohen SS, Borris DL, Aquilino EA, Glushakova S, Margolis LB, Orenstein JM, Offord RE, Neurath AR, Blauvelt A. Candidate microbicides block HIV-1 infection of human immature Langerhans cells within epithelial tissue explants. The Journal of Experimental Medicine. 192: 1491-500. PMID 11085750 DOI: 10.1084/Jem.192.10.1491 |
0.339 |
|
| 2000 |
Stöcklin R, Arrighi JF, Hoang-Van K, Vu L, Cerini F, Gilles N, Genet R, Markussen J, Offord RE, Rose K. Positive and negative labeling of human proinsulin, insulin, and C-peptide with stable isotopes. New tools for in vivo pharmacokinetic and metabolic studies. Methods in Molecular Biology (Clifton, N.J.). 146: 293-315. PMID 10948509 DOI: 10.1385/1-59259-045-4:293 |
0.332 |
|
| 2000 |
Torre VS, Marozsan AJ, Albright JL, Collins KR, Hartley O, Offord RE, Quiñones-Mateu ME, Arts EJ. Variable sensitivity of CCR5-tropic human immunodeficiency virus type 1 isolates to inhibition by RANTES analogs. Journal of Virology. 74: 4868-76. PMID 10775626 DOI: 10.1128/Jvi.74.10.4868-4876.2000 |
0.347 |
|
| 1999 |
Mosier DE, Picchio GR, Gulizia RJ, Sabbe R, Poignard P, Picard L, Offord RE, Thompson DA, Wilken J. Highly potent RANTES analogues either prevent CCR5-using human immunodeficiency virus type 1 infection in vivo or rapidly select for CXCR4- using variants Journal of Virology. 73: 3544-3550. PMID 10196243 DOI: 10.1128/Jvi.73.5.3544-3550.1999 |
0.383 |
|
| 1998 |
Kinter A, Catanzaro A, Monaco J, Ruiz M, Justement J, Moir S, Arthos J, Oliva A, Ehler L, Mizell S, Jackson R, Ostrowski M, Hoxie J, Offord R, Fauci AS. CC-chemokines enhance the replication of T-tropic strains of HIV-1 in CD4+ T cells: Role of signal transduction Proceedings of the National Academy of Sciences of the United States of America. 95: 11880-11885. PMID 9751759 DOI: 10.1073/Pnas.95.20.11880 |
0.31 |
|
| 1997 |
Kippen AD, Cerini F, Vadas L, Stöcklin R, Vu L, Offord RE, Rose K. Development of an isotope dilution assay for precise determination of insulin, C-peptide, and proinsulin levels in non-diabetic and type II diabetic individuals with comparison to immunoassay Journal of Biological Chemistry. 272: 12513-12522. PMID 9139702 DOI: 10.1074/Jbc.272.19.12513 |
0.316 |
|
| 1997 |
Simmons G, Clapham PR, Picard L, Offord RE, Rosenkilde MM, Schwartz TW, Buser R, Wells TNC, Proudfoot AEI. Potent Inhibition of HIV-1 Infectivity in Macrophages and Lymphocytes by a Novel CCR5 Antagonist Science. 276: 276-279. PMID 9092481 DOI: 10.1126/Science.276.5310.276 |
0.353 |
|
| 1996 |
Gaertner HF, Offord RE. Site-specific attachment of functionalized poly(ethylene glycol) to the amino terminus of proteins. Bioconjugate Chemistry. 7: 38-44. PMID 8741989 DOI: 10.1021/Bc950074D |
0.335 |
|
| 1996 |
Proudfoot AEI, Power CA, Hoogewerf AJ, Montjovent MO, Borlat F, Offord RE, Wells TNC. Extension of recombinant human RANTES by the retention of the initiating methionine produces a potent antagonist Journal of Biological Chemistry. 271: 2599-2603. PMID 8576227 DOI: 10.1074/Jbc.271.5.2599 |
0.315 |
|
| 1994 |
Mikolajczyk SD, Meyer DL, Starling JJ, Law KL, Rose K, Dufour B, Offord RE. High yield, site-specific coupling of N-terminally modified beta-lactamase to a proteolytically derived single-sulfhydryl murine Fab'. Bioconjugate Chemistry. 5: 636-46. PMID 7873667 DOI: 10.1021/Bc00030A020 |
0.359 |
|
| 1994 |
Werlen RC, Lankinen M, Rose K, Blakey D, Shuttleworth H, Melton R, Offord RE. Site-specific conjugation of an enzyme and an antibody fragment. Bioconjugate Chemistry. 5: 411-7. PMID 7849070 DOI: 10.1021/Bc00029A006 |
0.342 |
|
| 1994 |
Gaertner HF, Offord RE, Cotton R, Timms D, Camble R, Rose K. Site-specific religation of G-CSF fragments through a thioether bond. Bioconjugate Chemistry. 5: 333-8. PMID 7524688 DOI: 10.1021/Bc00028A009 |
0.361 |
|
| 1993 |
Vilaseca LA, Rose K, Werlen R, Meunier A, Offord RE, Nichols CL, Scott WL. Protein conjugates of defined structure: Synthesis and use of a new carrier molecule Bioconjugate Chemistry. 4: 515-520. PMID 8305521 DOI: 10.1021/Bc00024A014 |
0.325 |
|
| 1992 |
Fisch I, Künzi G, Rose K, Offord RE. Site-specific modification of a fragment of a chimeric monoclonal antibody using reverse proteolysis. Bioconjugate Chemistry. 3: 147-53. PMID 1515467 DOI: 10.1021/Bc00014A009 |
0.303 |
|
| 1992 |
Gaertner HF, Rose K, Cotton R, Timms D, Camble R, Offord RE. Construction of protein analogues by site-specific condensation of unprotected fragments. Bioconjugate Chemistry. 3: 262-8. PMID 1381617 DOI: 10.1021/Bc00015A010 |
0.396 |
|
| 1991 |
Rose K, Stöcklin R, Savoy LA, Regamey PO, Offord RE, Vuagnat P, Markussen J. Reaction mechanism of trypsin-catalysed semisynthesis of human insulin studied by fast atom bombardment mass spectrometry. Protein Engineering. 4: 409-12. PMID 1881866 DOI: 10.1093/Protein/4.4.409 |
0.331 |
|
| 1988 |
Varley JM, Davies JG, Shire D, Offord RE, Timmis KN. Engineered rat insulin I analogue having a B16 Tyr/Asp replacement exhibits unchanged susceptibility to cleavage by insulin proteinase. European Journal of Biochemistry. 171: 351-4. PMID 3276519 DOI: 10.1111/J.1432-1033.1988.Tb13797.X |
0.302 |
|
| 1988 |
Rose K, Herrero C, Proudfoot AE, Offord RE, Wallace CJ. Enzyme-assisted semisynthesis of polypeptide active esters and their use. The Biochemical Journal. 249: 83-8. PMID 2829852 DOI: 10.1042/Bj2490083 |
0.625 |
|
| 1987 |
Davies JG, Rose K, Bradshaw CG, Offord RE. Enzymatic semisynthesis of insulin specifically labelled with tritium at position B-30. Protein Engineering. 1: 407-11. PMID 3334095 DOI: 10.1093/Protein/1.5.407 |
0.316 |
|
| 1986 |
Proudfoot AE, Wallace CJ, Harris DE, Offord RE. A new non-covalent complex of semisynthetically modified tryptic fragments of cytochrome c. The Biochemical Journal. 239: 333-7. PMID 3028371 |
0.614 |
|
| 1984 |
Proudfoot AE, Offord RE, Rose K, Schmidt M, Wallace CJ. A case of spurious product formation during attempted resynthesis of proteins by reverse proteolysis. Some batches of 'pure' glycerol contain cross-linking agents. The Biochemical Journal. 221: 325-31. PMID 6089735 DOI: 10.1042/Bj2210325 |
0.623 |
|
| 1983 |
Rose K, Bairoch A, Offord RE. Amino acid sequence determination by gas chromatography-mass spectrometry of permethylated peptides. The application of capillary columns Journal of Chromatography A. 268: 197-206. DOI: 10.1016/S0021-9673(01)95406-8 |
0.335 |
|
| 1981 |
Rose K, Priddle JD, Offord RE. Affinity technique for the isolation of polypeptides containing arginine modified with cyclohexane-1,2-dione, and their analysis by combined gas-liquid chromatography-mass spectrometry Journal of Chromatography A. 210: 301-309. DOI: 10.1016/S0021-9673(00)97840-3 |
0.365 |
|
| 1979 |
Wallace CJ, Offord RE. The semisynthesis of fragments corresponding to residues 66-104 of horse heart cytochrome c. The Biochemical Journal. 179: 169-82. PMID 224859 |
0.629 |
|
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