| Year |
Citation |
Score |
| 2024 |
Zhang D, Zhang W, Ming C, Gao X, Yuan H, Lin X, Mao X, Wang C, Guo X, Du Y, Shao L, Yang R, Lin Z, Wu X, Huang TY, ... ... Xu H, et al. P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting p-tau217 with immunotherapy ameliorates murine tauopathy. Neuron. PMID 38513667 DOI: 10.1016/j.neuron.2024.02.017 |
0.722 |
|
| 2023 |
Cui Q, Liang S, Li H, Guo Y, Lv J, Wang X, Qin P, Xu H, Huang TY, Lu Y, Tian Q, Zhang T. SNX17 Mediates Dendritic Spine Maturation via p140Cap. Molecular Neurobiology. PMID 37704928 DOI: 10.1007/s12035-023-03620-4 |
0.656 |
|
| 2023 |
Lee CYD, De La Rocha AJ, Inouye K, Langfelder P, Daggett A, Gu X, Jiang LL, Pamonag Z, Vaca RG, Richman J, Kawaguchi R, Gao F, Xu H, Yang XW. BAC Transgenic Expression of Human TREM2-R47H Remodels Amyloid Plaques but Unable to Reprogram Plaque-associated Microglial Reactivity in 5xFAD Mice. Biorxiv : the Preprint Server For Biology. PMID 37577582 DOI: 10.1101/2023.08.03.551881 |
0.711 |
|
| 2023 |
Zhao Y, Zheng Q, Hong Y, Gao Y, Hu J, Lang M, Zhang H, Zhou Y, Luo H, Zhang X, Sun H, Yan XX, Huang TY, Wang YJ, Xu H, et al. β-Microglobulin coaggregates with Aβ and contributes to amyloid pathology and cognitive deficits in Alzheimer's disease model mice. Nature Neuroscience. PMID 37264159 DOI: 10.1038/s41593-023-01352-1 |
0.741 |
|
| 2023 |
Gao Y, Hong Y, Huang L, Zheng S, Zhang H, Wang S, Yao Y, Zhao Y, Zhu L, Xu Q, Chai X, Zeng Y, Zeng Y, Zheng L, Zhou Y, ... ... Xu H, et al. β2-microglobulin functions as an endogenous NMDAR antagonist to impair synaptic function. Cell. 186: 1026-1038.e20. PMID 36868208 DOI: 10.1016/j.cell.2023.01.021 |
0.635 |
|
| 2022 |
Leng L, Yuan Z, Pan R, Su X, Wang H, Xue J, Zhuang K, Gao J, Chen Z, Lin H, Xie W, Li H, Chen Z, Ren K, Zhang X, ... ... Xu H, et al. Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance. Nature Metabolism. PMID 36203054 DOI: 10.1038/s42255-022-00643-4 |
0.409 |
|
| 2022 |
Zhao P, Xu Y, Jiang L, Fan X, Li L, Li X, Arase H, Zhao Y, Cao W, Zheng H, Xu H, Tong Q, Zhang N, An Z. A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer's disease. Science Translational Medicine. 14: eabq0095. PMID 36070367 DOI: 10.1126/scitranslmed.abq0095 |
0.708 |
|
| 2022 |
Zhu B, Liu Y, Hwang S, Archuleta K, Huang H, Campos A, Murad R, Piña-Crespo J, Xu H, Huang TY. Trem2 deletion enhances tau dispersion and pathology through microglia exosomes. Molecular Neurodegeneration. 17: 58. PMID 36056435 DOI: 10.1186/s13024-022-00562-8 |
0.832 |
|
| 2022 |
Guo T, Pan X, Jiang G, Zhang D, Qi J, Shao L, Wang Z, Xu H, Zhao Y. Downregulating PTBP1 fails to convert astrocytes into hippocampal neurons and to alleviate symptoms in Alzheimer's mouse models. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 35944999 DOI: 10.1523/JNEUROSCI.1060-22.2022 |
0.375 |
|
| 2022 |
Wang C, Zhang Y, Zhao D, Huo Y, Xie J, Zhang X, Luo H, Xu H, Zhang YW. Phenazopyridine promotes RPS23RG1/Rps23rg1 transcription and ameliorates Alzheimer-associated phenotypes in mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 35821069 DOI: 10.1038/s41386-022-01373-7 |
0.366 |
|
| 2022 |
Zhao P, Xu Y, Jiang LL, Fan X, Ku Z, Li L, Liu X, Deng M, Arase H, Zhu JJ, Huang TY, Zhao Y, Zhang C, Xu H, Tong Q, et al. LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions. Molecular Neurodegeneration. 17: 44. PMID 35717259 DOI: 10.1186/s13024-022-00550-y |
0.77 |
|
| 2022 |
Shi D, Xie S, Li A, Wang Q, Guo H, Han Y, Xu H, Gan WB, Zhang L, Guo T. APOE-ε4 modulates the association among plasma Aβ/Aβ, vascular diseases, neurodegeneration and cognitive decline in non-demented elderly adults. Translational Psychiatry. 12: 128. PMID 35351867 DOI: 10.1038/s41398-022-01899-w |
0.309 |
|
| 2022 |
Zheng Q, Song B, Li G, Cai F, Wu M, Zhao Y, Jiang L, Guo T, Shen M, Hou H, Zhou Y, Zhao Y, Di A, Zhang L, Zeng F, ... ... Xu H, et al. USP25 inhibition ameliorates Alzheimer's pathology through the regulation of APP processing and Aβ generation. The Journal of Clinical Investigation. 132. PMID 35229730 DOI: 10.1172/JCI152170 |
0.808 |
|
| 2021 |
Sheng X, Yao Y, Huang R, Xu Y, Zhu Y, Chen L, Zhang L, Wang W, Zhuo R, Can D, Chang CF, Zhang YW, Xu H, Bu G, Zhong L, et al. Identification of the minimal active soluble TREM2 sequence for modulating microglial phenotypes and amyloid pathology. Journal of Neuroinflammation. 18: 286. PMID 34893068 DOI: 10.1186/s12974-021-02340-7 |
0.431 |
|
| 2021 |
Hu B, Duan S, Wang Z, Li X, Zhou Y, Zhang X, Zhang YW, Xu H, Zheng H. Insights Into the Role of CSF1R in the Central Nervous System and Neurological Disorders. Frontiers in Aging Neuroscience. 13: 789834. PMID 34867307 DOI: 10.3389/fnagi.2021.789834 |
0.348 |
|
| 2021 |
Xu P, Chang JC, Zhou X, Wang W, Bamkole M, Wong E, Bettayeb K, Jiang LL, Huang T, Luo W, Xu H, Nairn AC, Flajolet M, Ip NY, Li YM, et al. GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer's disease. The Journal of Experimental Medicine. 218. PMID 34156424 DOI: 10.1084/jem.20202446 |
0.832 |
|
| 2021 |
Cheng B, Li X, Dai K, Duan S, Rong Z, Chen Y, Lü L, Liu Z, Huang X, Xu H, Zhang YW, Zheng H. Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Interacts With Colony-Stimulating Factor 1 Receptor (CSF1R) but Is Not Necessary for CSF1/CSF1R-Mediated Microglial Survival. Frontiers in Immunology. 12: 633796. PMID 33841415 DOI: 10.3389/fimmu.2021.633796 |
0.309 |
|
| 2021 |
Zheng Q, Li G, Wang S, Zhou Y, Liu K, Gao Y, Zhou Y, Zheng L, Zhu L, Deng Q, Wu M, Di A, Zhang L, Zhao Y, Zhang H, ... ... Xu H, et al. Trisomy 21-induced dysregulation of microglial homeostasis in Alzheimer's brains is mediated by USP25. Science Advances. 7. PMID 33523861 DOI: 10.1126/sciadv.abe1340 |
0.363 |
|
| 2020 |
Meng J, Han L, Zheng N, Xu H, Liu Z, Zhang X, Luo H, Can D, Sun H, Xu H, Zhang YW. TMEM59 Haploinsufficiency Ameliorates the Pathology and Cognitive Impairment in the 5xFAD Mouse Model of Alzheimer's Disease. Frontiers in Cell and Developmental Biology. 8: 596030. PMID 33195275 DOI: 10.3389/fcell.2020.596030 |
0.446 |
|
| 2020 |
Liu T, Zhu B, Liu Y, Zhang X, Yin J, Li X, Jiang L, Hodges AP, Rosenthal SB, Zhou L, Yancey J, McQuade A, Blurton-Jones M, Tanzi RE, Huang TY, ... Xu H, et al. Multi-omic comparison of Alzheimer's variants in human ESC-derived microglia reveals convergence at APOE. The Journal of Experimental Medicine. 217. PMID 32941599 DOI: 10.1084/Jem.20200474 |
0.817 |
|
| 2020 |
Zhao D, Zhou Y, Huo Y, Meng J, Xiao X, Han L, Zhang X, Luo H, Can D, Sun H, Huang TY, Wang X, Zhang J, Liu FR, Xu H, et al. RPS23RG1 modulates tau phosphorylation and axon outgrowth through regulating p35 proteasomal degradation. Cell Death and Differentiation. PMID 32908202 DOI: 10.1038/S41418-020-00620-Y |
0.699 |
|
| 2020 |
Liu Z, Ning J, Zheng X, Meng J, Han L, Zheng H, Zhong L, Chen XF, Zhang X, Luo H, Can D, Xu H, Zhang YW. TMEM59 interacts with TREM2 and modulates TREM2-dependent microglial activities. Cell Death & Disease. 11: 678. PMID 32826884 DOI: 10.1038/S41419-020-02874-3 |
0.382 |
|
| 2020 |
Guo T, Zhang D, Zeng Y, Huang TY, Xu H, Zhao Y. Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease. Molecular Neurodegeneration. 15: 40. PMID 32677986 DOI: 10.1186/S13024-020-00391-7 |
0.752 |
|
| 2020 |
Stupack J, Xiong XP, Jiang LL, Zhang T, Zhou L, Campos A, Ranscht B, Mobley W, Pasquale EB, Xu H, Huang TY. Soluble SORLA enhances neurite outgrowth and regeneration through activation of the EGF Receptor/ERK signaling axis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 32601248 DOI: 10.1523/Jneurosci.0723-20.2020 |
0.76 |
|
| 2020 |
Zhang Z, Chen C, Jia S, Cao X, Liu M, Tian J, Hoffmann PR, Xu H, Ni J, Song G. Selenium restores synaptic deficits by modulating NMDA receptors and selenoprotein K in an Alzheimer's disease model. Antioxidants & Redox Signaling. PMID 32475153 DOI: 10.1089/ars.2019.7990 |
0.342 |
|
| 2020 |
Zhu Q, Jiang J, Gendron TF, McAlonis-Downes M, Jiang L, Taylor A, Diaz Garcia S, Ghosh Dastidar S, Rodriguez MJ, King P, Zhang Y, La Spada AR, Xu H, Petrucelli L, Ravits J, et al. Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72. Nature Neuroscience. PMID 32284607 DOI: 10.1038/S41593-020-0619-5 |
0.653 |
|
| 2020 |
Zhang F, Gannon M, Chen Y, Yan S, Zhang S, Feng W, Tao J, Sha B, Liu Z, Saito T, Saido T, Keene CD, Jiao K, Roberson ED, Xu H, et al. β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade. Science Translational Medicine. 12. PMID 31941827 DOI: 10.1126/Scitranslmed.Aay6931 |
0.463 |
|
| 2020 |
Liu FR, Yang LY, Zheng HF, Zhou Y, Chen BB, Xu H, Zhang YW, Shen DY. Plasma levels of Interleukin 18 but not amyloid-β or Tau are elevated in female depressive patients. Comprehensive Psychiatry. 97: 152159. PMID 31931428 DOI: 10.1016/J.Comppsych.2020.152159 |
0.421 |
|
| 2019 |
Zhou J, Chow HM, Liu Y, Wu D, Shi M, Li J, Wen L, Gao Y, Chen G, Zhuang K, Lin H, Zhang G, Xie W, Li H, Leng L, ... ... Xu H, et al. Cyclin-Dependent Kinase 5-Dependent BAG3 Degradation Modulates Synaptic Protein Turnover. Biological Psychiatry. PMID 31955914 DOI: 10.1016/J.Biopsych.2019.11.013 |
0.696 |
|
| 2019 |
Zeng F, Ma X, Zhu L, Xu Q, Zeng Y, Gao Y, Li G, Guo T, Zhang H, Tang X, Wang Z, Ye Z, Zheng L, Zhang H, Zheng Q, ... ... Xu H, et al. The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability. Plos Biology. 17: e3000525. PMID 31841517 DOI: 10.1371/Journal.Pbio.3000525 |
0.679 |
|
| 2019 |
Zhang C, Tan Z, Xie Y, Zhao Y, Huang TY, Lu Z, Luo H, Can D, Xu H, Zhang YW, Zhang X. Appoptosin Mediates Lesions Induced by Oxidative Stress Through the JNK-FoxO1 Pathway. Frontiers in Aging Neuroscience. 11: 243. PMID 31551758 DOI: 10.3389/Fnagi.2019.00243 |
0.672 |
|
| 2019 |
Xie Y, Niu M, Ji C, Huang TY, Zhang C, Tian Y, Shi Z, Wang C, Zhao Y, Luo H, Can D, Xu H, Zhang YW, Zhang X. SNX8 Enhances Non-amyloidogenic APP Trafficking and Attenuates Aβ Accumulation and Memory Deficits in an AD Mouse. Frontiers in Cellular Neuroscience. 13: 410. PMID 31551717 DOI: 10.3389/Fncel.2019.00410 |
0.764 |
|
| 2019 |
Huang TY, Xu H. Bringing Order out of Chaos: Establishing an Epistatic Relationship between CD33 and TREM2. Neuron. 103: 747-749. PMID 31487521 DOI: 10.1016/J.Neuron.2019.08.019 |
0.669 |
|
| 2019 |
Zhao S, Li Z, Zhang M, Zhang L, Zheng H, Ning J, Wang Y, Wang F, Zhang X, Gan H, Wang Y, Zhang X, Luo H, Bu G, Xu H, et al. A brain somatic RHEB doublet mutation causes focal cortical dysplasia type II. Experimental & Molecular Medicine. 51: 84. PMID 31337748 DOI: 10.1038/S12276-019-0277-4 |
0.342 |
|
| 2019 |
Zhong L, Xu Y, Zhuo R, Wang T, Wang K, Huang R, Wang D, Gao Y, Zhu Y, Sheng X, Chen K, Wang N, Zhu L, Can D, Marten Y, ... ... Xu H, et al. Author Correction: Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model. Nature Communications. 10: 2923. PMID 31266955 DOI: 10.1038/S41467-019-10950-2 |
0.322 |
|
| 2019 |
Jiang LL, Zhu B, Zhao Y, Li X, Liu T, Pina-Crespo J, Zhou L, Xu W, Rodriguez MJ, Yu H, Cleveland DW, Ravits J, Da Cruz S, Long T, Huang TY, ... Xu H, et al. Membralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment. The Journal of Clinical Investigation. 130. PMID 31112137 DOI: 10.1172/Jci127695 |
0.769 |
|
| 2019 |
Zhong L, Xu Y, Zhuo R, Wang T, Wang K, Huang R, Wang D, Gao Y, Zhu Y, Sheng X, Chen K, Wang N, Zhu L, Can D, Marten Y, ... ... Xu H, et al. Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model. Nature Communications. 10: 1365. PMID 30911003 DOI: 10.1038/S41467-019-09118-9 |
0.566 |
|
| 2018 |
Zeng Y, Wang N, Guo T, Zheng Q, Wang S, Wu S, Li X, Wu J, Chen Z, Xu H, Wang X, Lin B. Deletion Promotes Recovery From Spinal Cord Injury by Neuroprotection and Reduces Macrophage/Microglia Proliferation. Frontiers in Neurology. 9: 1059. PMID 30619032 DOI: 10.3389/Fneur.2018.01059 |
0.303 |
|
| 2018 |
Cockerill I, Oliver JA, Xu H, Fu BM, Zhu D. Blood-Brain Barrier Integrity and Clearance of Amyloid-β from the BBB. Advances in Experimental Medicine and Biology. 1097: 261-278. PMID 30315550 DOI: 10.1007/978-3-319-96445-4_14 |
0.41 |
|
| 2018 |
Zhao D, Meng J, Zhao Y, Huo Y, Liu Y, Zheng N, Zhang M, Gao Y, Chen Z, Sun H, Wang X, Jing C, Zhang T, Zhang X, Luo H, ... ... Xu H, et al. RPS23RG1 Is Required for Synaptic Integrity and Rescues Alzheimer's Disease-Associated Cognitive Deficits. Biological Psychiatry. PMID 30292394 DOI: 10.1016/J.Biopsych.2018.08.009 |
0.714 |
|
| 2018 |
Leng L, Zhuang K, Liu Z, Huang C, Gao Y, Chen G, Lin H, Hu Y, Wu D, Shi M, Xie W, Sun H, Shao Z, Li H, Zhang K, ... ... Xu H, et al. Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation. Neuron. PMID 30220511 DOI: 10.1016/J.Neuron.2018.08.031 |
0.648 |
|
| 2018 |
Simandi Z, Pajer K, Karolyi K, Sieler T, Jiang LL, Kolostyak Z, Sari Z, Fekecs Z, Pap A, Patsalos A, Contreras GA, Reho B, Papp Z, Guo X, Horvath A, ... ... Xu H, et al. Arginine methyltransferase PRMT8 provides cellular stress tolerance in aging motoneurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 30054395 DOI: 10.1523/Jneurosci.3389-17.2018 |
0.622 |
|
| 2018 |
Zhuang K, Huang C, Leng L, Zheng H, Gao Y, Chen G, Ji Z, Sun H, Hu Y, Wu D, Shi M, Li H, Zhao Y, Zhang Y, Xue M, ... ... Xu H, et al. Neuron-Specific Menin Deletion Leads to Synaptic Dysfunction and Cognitive Impairment by Modulating p35 Expression. Cell Reports. 24: 701-712. PMID 30021166 DOI: 10.1016/J.Celrep.2018.06.055 |
0.662 |
|
| 2018 |
Pan G, Chen Z, Zheng H, Zhang Y, Xu H, Bu G, Zheng H, Li Y. Compensatory Mechanisms Modulate the Neuronal Excitability in a Kainic Acid-Induced Epilepsy Mouse Model. Frontiers in Neural Circuits. 12: 48. PMID 30008664 DOI: 10.3389/Fncir.2018.00048 |
0.312 |
|
| 2018 |
Li X, Cui XX, Chen YJ, Wu TT, Xu H, Yin H, Wu YC. Therapeutic Potential of a Prolyl Hydroxylase Inhibitor FG-4592 for Parkinson's Diseases and : Regulation of Redox Biology and Mitochondrial Function. Frontiers in Aging Neuroscience. 10: 121. PMID 29755339 DOI: 10.3389/Fnagi.2018.00121 |
0.323 |
|
| 2018 |
Du Y, Zhao Y, Li C, Zheng Q, Tian J, Li Z, Huang TY, Zhang W, Xu H. Inhibition of PKCδ reduces amyloid-β levels and reverses Alzheimer disease phenotypes. The Journal of Experimental Medicine. PMID 29739836 DOI: 10.1084/Jem.20171193 |
0.776 |
|
| 2018 |
Zhang H, Huang T, Hong Y, Yang W, Zhang X, Luo H, Xu H, Wang X. The Retromer Complex and Sorting Nexins in Neurodegenerative Diseases. Frontiers in Aging Neuroscience. 10: 79. PMID 29632483 DOI: 10.3389/Fnagi.2018.00079 |
0.754 |
|
| 2018 |
Zhong L, Wang Z, Wang D, Wang Z, Martens YA, Wu L, Xu Y, Wang K, Li J, Huang R, Can D, Xu H, Bu G, Chen XF. Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2). Molecular Neurodegeneration. 13: 15. PMID 29587871 DOI: 10.1186/S13024-018-0247-7 |
0.496 |
|
| 2018 |
Lee CYD, Daggett A, Gu X, Jiang LL, Langfelder P, Li X, Wang N, Zhao Y, Park CS, Cooper Y, Ferando I, Mody I, Coppola G, Xu H, Yang XW. Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models. Neuron. 97: 1032-1048.e5. PMID 29518357 DOI: 10.1016/J.Neuron.2018.02.002 |
0.737 |
|
| 2018 |
Zhao Y, Wu X, Li X, Jiang LL, Gui X, Liu Y, Sun Y, Zhu B, Piña-Crespo JC, Zhang M, Zhang N, Chen X, Bu G, An Z, Huang TY, ... Xu H, et al. TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function. Neuron. 97: 1023-1031.e7. PMID 29518356 DOI: 10.1016/J.Neuron.2018.01.031 |
0.836 |
|
| 2018 |
Zhu D, Su Y, Fu B, Xu H. Magnesium Reduces Blood-Brain Barrier Permeability and Regulates Amyloid-β Transcytosis. Molecular Neurobiology. PMID 29383689 DOI: 10.1007/S12035-018-0896-0 |
0.461 |
|
| 2017 |
Zhao Y, Li X, Huang T, Jiang LL, Tan Z, Zhang M, Cheng IH, Wang X, Bu G, Zhang YW, Wang Q, Xu H. Intracellular trafficking of TREM2 is regulated by presenilin 1. Experimental & Molecular Medicine. 49: e405. PMID 29611543 DOI: 10.1038/Emm.2017.200 |
0.831 |
|
| 2017 |
Wu XL, Piña-Crespo J, Zhang YW, Chen XC, Xu HX. Tau-mediated Neurodegeneration and Potential Implications in Diagnosis and Treatment of Alzheimer's Disease. Chinese Medical Journal. 130: 2978-2990. PMID 29237931 DOI: 10.4103/0366-6999.220313 |
0.773 |
|
| 2017 |
Zhu B, Jiang L, Huang T, Zhao Y, Liu T, Zhong Y, Li X, Campos A, Pomeroy K, Masliah E, Zhang D, Xu H. ER-associated degradation regulates Alzheimer's amyloid pathology and memory function by modulating γ-secretase activity. Nature Communications. 8: 1472. PMID 29133892 DOI: 10.1038/S41467-017-01799-4 |
0.832 |
|
| 2017 |
Tu S, Akhtar MW, Escorihuela RM, Amador-Arjona A, Swarup V, Parker J, Zaremba JD, Holland T, Bansal N, Holohan DR, Lopez K, Ryan SD, Chan SF, Yan L, Zhang X, ... ... Xu H, et al. NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism. Nature Communications. 8: 1488. PMID 29133852 DOI: 10.1038/S41467-017-01563-8 |
0.353 |
|
| 2017 |
Huang TY, Zhao Y, Jiang LL, Li X, Liu Y, Sun Y, Piña-Crespo JC, Zhu B, Masliah E, Willnow TE, Pasquale EB, Xu H. SORLA attenuates EphA4 signaling and amyloid β-induced neurodegeneration. The Journal of Experimental Medicine. PMID 29114064 DOI: 10.1084/Jem.20171413 |
0.841 |
|
| 2017 |
Li Y, Chen Z, Gao Y, Pan G, Zheng H, Zhang Y, Xu H, Bu G, Zheng H. Synaptic adhesion molecule Pcdh-γC5 mediates synaptic dysfunction in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28842416 DOI: 10.1523/Jneurosci.1051-17.2017 |
0.439 |
|
| 2017 |
Zhong L, Zhang ZL, Li X, Liao C, Mou P, Wang T, Wang Z, Wang Z, Wei M, Xu H, Bu G, Chen XF. TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway. Frontiers in Aging Neuroscience. 9: 204. PMID 28680398 DOI: 10.3389/Fnagi.2017.00204 |
0.417 |
|
| 2017 |
Zhong L, Chen XF, Wang T, Wang Z, Liao C, Wang Z, Huang R, Wang D, Li X, Wu L, Jia L, Zheng H, Painter M, Atagi Y, Liu CC, ... ... Xu H, et al. Soluble TREM2 induces inflammatory responses and enhances microglial survival. The Journal of Experimental Medicine. PMID 28209725 DOI: 10.1084/Jem.20160844 |
0.448 |
|
| 2017 |
Zheng H, Jia L, Liu CC, Li Zhong ZR, Yang L, Chen XF, Fryer JD, Wang X, Zhang YW, Xu H, Bu G. TREM2 promotes microglial survival by activating Wnt/β-catenin pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28077724 DOI: 10.1523/Jneurosci.2459-16.2017 |
0.48 |
|
| 2016 |
Zheng Q, Huang T, Zhang L, Zhou Y, Luo H, Xu H, Wang X. Dysregulation of Ubiquitin-Proteasome System in Neurodegenerative Diseases. Frontiers in Aging Neuroscience. 8: 303. PMID 28018215 DOI: 10.3389/Fnagi.2016.00303 |
0.693 |
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| 2016 |
Wang X, Zhou Y, Wang J, Tseng IC, Huang T, Zhao Y, Zheng Q, Gao Y, Luo H, Zhang X, Bu G, Hong W, Xu H. SNX27 Deletion Causes Hydrocephalus by Impairing Ependymal Cell Differentiation and Ciliogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 12586-12597. PMID 27974614 DOI: 10.1523/Jneurosci.1620-16.2016 |
0.683 |
|
| 2016 |
Yang L, Liu CC, Zheng H, Kanekiyo T, Atagi Y, Jia L, Wang D, N'songo A, Can D, Xu H, Chen XF, Bu G. LRP1 modulates the microglial immune response via regulation of JNK and NF-κB signaling pathways. Journal of Neuroinflammation. 13: 304. PMID 27931217 DOI: 10.1186/S12974-016-0772-7 |
0.475 |
|
| 2016 |
Huang TY, Zhao Y, Li X, Wang X, Tseng IC, Thompson R, Tu S, Willnow TE, Zhang YW, Xu H. SNX27 and SORLA Interact to Reduce Amyloidogenic Subcellular Distribution and Processing of Amyloid Precursor Protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 7996-8011. PMID 27466343 DOI: 10.1523/Jneurosci.0206-16.2016 |
0.784 |
|
| 2016 |
Wang C, Niu M, Zhou Z, Zheng X, Zhang L, Tian Y, Yu X, Bu G, Xu H, Ma Q, Zhang YW. VPS35 regulates cell surface recycling and signaling of dopamine receptor D1. Neurobiology of Aging. 46: 22-31. PMID 27460146 DOI: 10.1016/J.Neurobiolaging.2016.05.016 |
0.337 |
|
| 2016 |
Zheng Q, Zheng X, Zhang L, Luo H, Qian L, Fu X, Liu Y, Gao Y, Niu M, Meng J, Zhang M, Bu G, Xu H, Zhang YW. The Neuron-Specific Protein TMEM59L Mediates Oxidative Stress-Induced Cell Death. Molecular Neurobiology. PMID 27324899 DOI: 10.1007/S12035-016-9997-9 |
0.365 |
|
| 2016 |
Zheng H, Liu CC, Atagi Y, Chen XF, Jia L, Yang L, He W, Zhang X, Kang SS, Rosenberry TL, Fryer JD, Zhang YW, Xu H, Bu G. Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation. Neurobiology of Aging. 42: 132-41. PMID 27143430 DOI: 10.1016/J.Neurobiolaging.2016.03.004 |
0.514 |
|
| 2016 |
Zhang X, Hu J, Zhong L, Wang N, Yang L, Liu CC, Li H, Wang X, Zhou Y, Zhang Y, Xu H, Bu G, Zhuang J. Quercetin stabilizes apolipoprotein E and reduces brain Aβ levels in amyloid model mice. Neuropharmacology. PMID 27114256 DOI: 10.1016/J.Neuropharm.2016.04.032 |
0.516 |
|
| 2016 |
Li Y, Sun H, Chen Z, Xu H, Bu G, Zheng H. Implications of GABAergic Neurotransmission in Alzheimer's Disease. Frontiers in Aging Neuroscience. 8: 31. PMID 26941642 DOI: 10.3389/Fnagi.2016.00031 |
0.542 |
|
| 2016 |
Barini E, Antico O, Zhao Y, Asta F, Tucci V, Catelani T, Marotta R, Xu H, Gasparini L. Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy. Molecular Neurodegeneration. 11: 16. PMID 26858121 DOI: 10.1186/S13024-016-0082-7 |
0.433 |
|
| 2016 |
Zhang C, Shi Z, Zhang L, Zhou Z, Zheng X, Liu G, Bu G, Fraser PE, Xu H, Zhang YW. Appoptosin interacts with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology. Journal of Cell Science. PMID 26813789 DOI: 10.1242/Jcs.176792 |
0.307 |
|
| 2016 |
Yan L, Chen Y, Li W, Huang X, Badie H, Jian F, Huang T, Zhao Y, Cohen SN, Li L, Zhang YW, Luo H, Tu S, Xu H. RPS23RG1 reduces Aβ oligomer-induced synaptic and cognitive deficits. Scientific Reports. 6: 18668. PMID 26733416 DOI: 10.1038/Srep18668 |
0.743 |
|
| 2015 |
Atagi Y, Liu CC, Painter MM, Chen XF, Verbeeck C, Zheng H, Li X, Rademakers R, Kang SS, Xu H, Younkin S, Das P, Fryer JD, Bu G. Apolipoprotein E is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2). The Journal of Biological Chemistry. PMID 26374899 DOI: 10.1074/Jbc.M115.679043 |
0.492 |
|
| 2015 |
Painter MM, Atagi Y, Liu CC, Rademakers R, Xu H, Fryer JD, Bu G. TREM2 in CNS homeostasis and neurodegenerative disease. Molecular Neurodegeneration. 10: 43. PMID 26337043 DOI: 10.1186/S13024-015-0040-9 |
0.407 |
|
| 2015 |
Zhao Y, Tseng IC, Heyser CJ, Rockenstein E, Mante M, Adame A, Zheng Q, Huang T, Wang X, Arslan PE, Chakrabarty P, Wu C, Bu G, Mobley WC, Zhang YW, ... ... Xu H, et al. Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis. Neuron. 87: 963-75. PMID 26335643 DOI: 10.1016/J.Neuron.2015.08.020 |
0.714 |
|
| 2015 |
Feng T, Niu M, Ji C, Gao Y, Wen J, Bu G, Xu H, Zhang YW. SNX15 Regulates Cell Surface Recycling of APP and Aβ Generation. Molecular Neurobiology. PMID 26115702 DOI: 10.1007/S12035-015-9306-Z |
0.567 |
|
| 2015 |
Feng Y, Liu T, Dong SY, Guo YJ, Jankovic J, Xu H, Wu YC. Rotenone affects p53 transcriptional activity and apoptosis via targeting SIRT1 and H3K9 acetylation in SH-SY5Y cells. Journal of Neurochemistry. 134: 668-76. PMID 25991017 DOI: 10.1111/Jnc.13172 |
0.323 |
|
| 2015 |
Zhong L, Chen XF, Zhang ZL, Wang Z, Shi XZ, Xu K, Zhang YW, Xu H, Bu G. DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response. The Journal of Biological Chemistry. 290: 15866-77. PMID 25957402 DOI: 10.1074/Jbc.M115.645986 |
0.359 |
|
| 2015 |
Hu J, Liu CC, Chen XF, Zhang YW, Xu H, Bu G. Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice. Molecular Neurodegeneration. 10: 6. PMID 25871773 DOI: 10.1186/S13024-015-0001-3 |
0.493 |
|
| 2015 |
Zhou J, Li H, Li X, Zhang G, Niu Y, Yuan Z, Herrup K, Zhang YW, Bu G, Xu H, Zhang J. The roles of Cdk5-mediated subcellular localization of FOXO1 in neuronal death. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 2624-35. PMID 25673854 DOI: 10.1523/Jneurosci.3051-14.2015 |
0.392 |
|
| 2015 |
Hu J, Lin T, Gao Y, Xu J, Jiang C, Wang G, Bu G, Xu H, Chen H, Zhang YW. The resveratrol trimer miyabenol C inhibits β-secretase activity and β-amyloid generation. Plos One. 10: e0115973. PMID 25629409 DOI: 10.1371/Journal.Pone.0115973 |
0.475 |
|
| 2015 |
Hou P, Liu G, Zhao Y, Shi Z, Zheng Q, Bu G, Xu H, Zhang YW. The role of copper and the copper-related protein CUTA in mediating APP processing and Aβ generation. Neurobiology of Aging. 36: 1310-5. PMID 25557959 DOI: 10.1016/J.Neurobiolaging.2014.12.005 |
0.497 |
|
| 2015 |
Shukla M, Htoo HH, Wintachai P, Hernandez JF, Dubois C, Postina R, Xu H, Checler F, Smith DR, Govitrapong P, Vincent B. Melatonin stimulates the nonamyloidogenic processing of βAPP through the positive transcriptional regulation of ADAM10 and ADAM17. Journal of Pineal Research. 58: 151-65. PMID 25491598 DOI: 10.1111/Jpi.12200 |
0.485 |
|
| 2014 |
Zhang X, Li Y, Xu H, Zhang YW. The γ-secretase complex: from structure to function. Frontiers in Cellular Neuroscience. 8: 427. PMID 25565961 DOI: 10.3389/Fncel.2014.00427 |
0.444 |
|
| 2014 |
Wang X, Huang T, Zhao Y, Zheng Q, Thompson RC, Bu G, Zhang YW, Hong W, Xu H. Sorting nexin 27 regulates Aβ production through modulating γ-secretase activity. Cell Reports. 9: 1023-33. PMID 25437557 DOI: 10.1016/J.Celrep.2014.09.037 |
0.771 |
|
| 2014 |
Tu S, Okamoto S, Lipton SA, Xu H. Oligomeric Aβ-induced synaptic dysfunction in Alzheimer's disease. Molecular Neurodegeneration. 9: 48. PMID 25394486 DOI: 10.1186/1750-1326-9-48 |
0.492 |
|
| 2014 |
Liu CC, Tsai CW, Deak F, Rogers J, Penuliar M, Sung YM, Maher JN, Fu Y, Li X, Xu H, Estus S, Hoe HS, Fryer JD, Kanekiyo T, Bu G. Deficiency in LRP6-mediated Wnt signaling contributes to synaptic abnormalities and amyloid pathology in Alzheimer's disease. Neuron. 84: 63-77. PMID 25242217 DOI: 10.1016/J.Neuron.2014.08.048 |
0.554 |
|
| 2014 |
Wang X, Huang T, Bu G, Xu H. Dysregulation of protein trafficking in neurodegeneration. Molecular Neurodegeneration. 9: 31. PMID 25152012 DOI: 10.1186/1750-1326-9-31 |
0.759 |
|
| 2014 |
Jiang S, Li Y, Zhang C, Zhao Y, Bu G, Xu H, Zhang YW. M1 muscarinic acetylcholine receptor in Alzheimer's disease. Neuroscience Bulletin. 30: 295-307. PMID 24590577 DOI: 10.1007/S12264-013-1406-Z |
0.428 |
|
| 2014 |
Kanekiyo T, Xu H, Bu G. ApoE and Aβ in Alzheimer's disease: accidental encounters or partners? Neuron. 81: 740-54. PMID 24559670 DOI: 10.1016/J.Neuron.2014.01.045 |
0.503 |
|
| 2014 |
Chen Y, Wang B, Liu D, Li JJ, Xue Y, Sakata K, Zhu LQ, Heldt SA, Xu H, Liao FF. Hsp90 chaperone inhibitor 17-AAG attenuates Aβ-induced synaptic toxicity and memory impairment. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 2464-70. PMID 24523537 DOI: 10.1523/Jneurosci.0151-13.2014 |
0.447 |
|
| 2014 |
Jiang S, Li Y, Zhang X, Bu G, Xu H, Zhang YW. Trafficking regulation of proteins in Alzheimer's disease. Molecular Neurodegeneration. 9: 6. PMID 24410826 DOI: 10.1186/1750-1326-9-6 |
0.531 |
|
| 2013 |
Sun L, Zhao Y, Zhou K, Freeze HH, Zhang YW, Xu H. Insufficient ER-stress response causes selective mouse cerebellar granule cell degeneration resembling that seen in congenital disorders of glycosylation. Molecular Brain. 6: 52. PMID 24305089 DOI: 10.1186/1756-6606-6-52 |
0.342 |
|
| 2013 |
Zhang YW, Chen Y, Liu Y, Zhao Y, Liao F, Xu H. APP regulates NGF receptor trafficking and NGF-mediated neuronal differentiation and survival. Plos One. 8. PMID 24224055 DOI: 10.1371/Journal.Pone.0080571 |
0.435 |
|
| 2013 |
Chen XF, Zhang YW, Xu H, Bu G. Transcriptional regulation and its misregulation in Alzheimer's disease. Molecular Brain. 6: 44. PMID 24144318 DOI: 10.1186/1756-6606-6-44 |
0.499 |
|
| 2013 |
Nakanishi N, Ryan SD, Zhang X, Khan A, Holland T, Cho EG, Huang X, Liao FF, Xu H, Lipton SA, Tu S. Synaptic protein α1-takusan mitigates amyloid-β-induced synaptic loss via interaction with tau and postsynaptic density-95 at postsynaptic sites. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 14170-83. PMID 23986251 DOI: 10.1523/Jneurosci.4646-10.2013 |
0.46 |
|
| 2013 |
Li X, Liu Y, Zheng Q, Yao G, Cheng P, Bu G, Xu H, Zhang YW. Ferritin light chain interacts with PEN-2 and affects γ-secretase activity. Neuroscience Letters. 548: 90-4. PMID 23685131 DOI: 10.1016/J.Neulet.2013.05.018 |
0.434 |
|
| 2013 |
Wang X, Zhao Y, Zhang X, Badie H, Zhou Y, Mu Y, Loo LS, Cai L, Thompson RC, Yang B, Chen Y, Johnson PF, Wu C, Bu G, Mobley WC, ... ... Xu H, et al. Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome. Nature Medicine. 19: 473-80. PMID 23524343 DOI: 10.1038/Nm.3117 |
0.372 |
|
| 2013 |
Liu CC, Liu CC, Kanekiyo T, Xu H, Bu G. Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy. Nature Reviews. Neurology. 9: 106-18. PMID 23296339 DOI: 10.1038/Nrneurol.2012.263 |
0.446 |
|
| 2013 |
Wang X, Zhao Y, Zhang X, Zhou Y, Ranscht B, Gage FH, Mobley WC, Zhang Y, Lipton SA, Hong W, Xu H. A novel mechanism underlying pathogenesis of Down syndrome Molecular Neurodegeneration. 8: O23. DOI: 10.1186/1750-1326-8-S1-O23 |
0.44 |
|
| 2013 |
Liu CC, Kanekiyo T, Xu H, Bu G. Erratum: Apolipoprotein e and Alzheimer disease: Risk, mechanisms and therapy (Nature Reviews Neurology (2013) 9 (106-118)) Nature Reviews Neurology. 9. DOI: 10.1038/Nrneurol2013.32 |
0.328 |
|
| 2012 |
Li J, Kanekiyo T, Shinohara M, Zhang Y, LaDu MJ, Xu H, Bu G. Differential regulation of amyloid-β endocytic trafficking and lysosomal degradation by apolipoprotein E isoforms. The Journal of Biological Chemistry. 287: 44593-601. PMID 23132858 DOI: 10.1074/Jbc.M112.420224 |
0.53 |
|
| 2012 |
Zhang H, Zhang YW, Chen Y, Huang X, Zhou F, Wang W, Xian B, Zhang X, Masliah E, Chen Q, Han JD, Bu G, Reed JC, Liao FF, Chen YG, ... Xu H, et al. Appoptosin is a novel pro-apoptotic protein and mediates cell death in neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 15565-76. PMID 23115192 DOI: 10.1523/Jneurosci.3668-12.2012 |
0.409 |
|
| 2012 |
Chen Y, Huang X, Zhang YW, Rockenstein E, Bu G, Golde TE, Masliah E, Xu H. Alzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 11390-5. PMID 22895721 DOI: 10.1523/Jneurosci.0757-12.2012 |
0.541 |
|
| 2012 |
Kwak YD, Wang B, Li JJ, Wang R, Deng Q, Diao S, Chen Y, Xu R, Masliah E, Xu H, Sung JJ, Liao FF. Upregulation of the E3 ligase NEDD4-1 by oxidative stress degrades IGF-1 receptor protein in neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 10971-81. PMID 22875931 DOI: 10.1523/Jneurosci.1836-12.2012 |
0.395 |
|
| 2012 |
Zhang H, Ma Q, Zhang YW, Xu H. Proteolytic processing of Alzheimer's β-amyloid precursor protein. Journal of Neurochemistry. 120: 9-21. PMID 22122372 DOI: 10.1111/J.1471-4159.2011.07519.X |
0.551 |
|
| 2012 |
Huang X, Chen Y, Zhang H, Ma Q, Zhang YW, Xu H. Salubrinal attenuates β-amyloid-induced neuronal death and microglial activation by inhibition of the NF-κB pathway. Neurobiology of Aging. 33: 1007.e9-17. PMID 22056200 DOI: 10.1016/J.Neurobiolaging.2011.10.007 |
0.497 |
|
| 2012 |
Zhang Y, Xu H. Identifying an APP-binding protein in neuronal cell death Molecular Neurodegeneration. 7: L22. DOI: 10.1186/1750-1326-7-S1-L22 |
0.369 |
|
| 2011 |
Kwak YD, Wang R, Li JJ, Zhang YW, Xu H, Liao FF. Differential regulation of BACE1 expression by oxidative and nitrosative signals. Molecular Neurodegeneration. 6: 17. PMID 21371311 DOI: 10.1186/1750-1326-6-17 |
0.495 |
|
| 2011 |
Zhang YW, Thompson R, Zhang H, Xu H. APP processing in Alzheimer's disease. Molecular Brain. 4: 3. PMID 21214928 DOI: 10.1186/1756-6606-4-3 |
0.545 |
|
| 2010 |
Kwak YD, Ma T, Diao S, Zhang X, Chen Y, Hsu J, Lipton SA, Masliah E, Xu H, Liao FF. NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration. Molecular Neurodegeneration. 5: 49. PMID 21067594 DOI: 10.1186/1750-1326-5-49 |
0.429 |
|
| 2010 |
Huang X, Chen Y, Li WB, Cohen SN, Liao FF, Li L, Xu H, Zhang YW. The Rps23rg gene family originated through retroposition of the ribosomal protein s23 mRNA and encodes proteins that decrease Alzheimer's β-amyloid level and tau phosphorylation Human Molecular Genetics. 19: 3835-3843. PMID 20650958 DOI: 10.1093/Hmg/Ddq302 |
0.491 |
|
| 2010 |
Zhang YW, Xu H. Substrate check of gamma-secretase. Nature Structural & Molecular Biology. 17: 140-1. PMID 20130572 DOI: 10.1038/Nsmb0210-140 |
0.485 |
|
| 2010 |
Kwak YD, Wang B, Pan W, Xu H, Jiang X, Liao FF. Functional interaction of phosphatase and tensin homologue (PTEN) with the E3 ligase NEDD4-1 during neuronal response to zinc. The Journal of Biological Chemistry. 285: 9847-57. PMID 20100827 DOI: 10.1074/Jbc.M109.091637 |
0.384 |
|
| 2010 |
Bulloj A, Leal MC, Xu H, Castaño EM, Morelli L. Insulin-Degrading Enzyme Sorting in Exosomes: A Secretory Pathway for a Key Brain Amyloid-β Degrading Protease Journal of Alzheimer's Disease. 19: 79-95. PMID 20061628 DOI: 10.3233/Jad-2010-1206 |
0.489 |
|
| 2010 |
Zhang Y, Huang X, Chen Y, Liao F, Li L, Xu H. P2-312: The Rps23r1 gene family regulates Alzheimer's beta-amyloid generation and tau phosphorylation Alzheimer's & Dementia. 6: S405-S405. DOI: 10.1016/J.Jalz.2010.05.1363 |
0.432 |
|
| 2010 |
Zhang H, Zhang Y, Huang X, Chen Y, Xu H. Appoptosin interacts with amyloid precursor protein and mediates neuronal toxicity via caspase depended pathway Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.1262 |
0.424 |
|
| 2009 |
Zhang YW, Liu S, Zhang X, Li WB, Chen Y, Huang X, Sun L, Luo W, Netzer WJ, Threadgill R, Wiegand G, Wang R, Cohen SN, Greengard P, Liao FF, ... ... Xu H, et al. A functional mouse retroposed gene Rps23r1 reduces Alzheimer's beta-amyloid levels and tau phosphorylation. Neuron. 64: 328-40. PMID 19914182 DOI: 10.1016/J.Neuron.2009.08.036 |
0.661 |
|
| 2009 |
Dunys J, Sevalle J, Giaime E, Pardossi-Piquard R, Vitek MP, Renbaum P, Levy-Lahad E, Zhang YW, Xu H, Checler F, da Costa CA. p53-dependent control of transactivation of the Pen2 promoter by presenilins. Journal of Cell Science. 122: 4003-8. PMID 19889971 DOI: 10.1242/Jcs.051169 |
0.442 |
|
| 2009 |
Ma T, Zhao Y, Kwak YD, Yang Z, Thompson R, Luo Z, Xu H, Liao FF. Statin's excitoprotection is mediated by sAPP and the subsequent attenuation of calpain-induced truncation events, likely via rho-ROCK signaling. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 11226-36. PMID 19741129 DOI: 10.1523/Jneurosci.6150-08.2009 |
0.417 |
|
| 2009 |
You X, Zhang YW, Chen Y, Huang X, Xu R, Cao X, Chen J, Liu Y, Zhang X, Xu H. Retinoid X receptor-alpha mediates (R )-flurbiprofen's effect on the levels of Alzheimer's beta-amyloid. Journal of Neurochemistry. 111: 142-9. PMID 19659691 DOI: 10.1111/J.1471-4159.2009.06312.X |
0.47 |
|
| 2009 |
Liao F, Xu H. Insulin Signaling in Sporadic Alzheimer’s Disease Science Signaling. 2. PMID 19509405 DOI: 10.1126/Scisignal.274Pe36 |
0.462 |
|
| 2009 |
Liu Y, Zhang YW, Wang X, Zhang H, You X, Liao FF, Xu H. Intracellular trafficking of presenilin 1 is regulated by beta-amyloid precursor protein and phospholipase D1. The Journal of Biological Chemistry. 284: 12145-52. PMID 19276086 DOI: 10.1074/Jbc.M808497200 |
0.467 |
|
| 2009 |
Chen Y, Zhou K, Wang R, Liu Y, Kwak YD, Ma T, Thompson RC, Zhao Y, Smith L, Gasparini L, Luo Z, Xu H, Liao FF. Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription. Proceedings of the National Academy of Sciences of the United States of America. 106: 3907-12. PMID 19237574 DOI: 10.1073/Pnas.0807991106 |
0.456 |
|
| 2008 |
Bulloj A, Leal MC, Surace EI, Zhang X, Xu H, Ledesma MD, Castaño EM, Morelli L. Detergent resistant membrane-associated IDE in brain tissue and cultured cells: Relevance to Abeta and insulin degradation. Molecular Neurodegeneration. 3: 22. PMID 19117523 DOI: 10.1186/1750-1326-3-22 |
0.461 |
|
| 2008 |
Xiong H, Callaghan D, Jones A, Walker DG, Lue LF, Beach TG, Sue LI, Woulfe J, Xu H, Stanimirovic DB, Zhang W. Cholesterol retention in Alzheimer's brain is responsible for high beta- and gamma-secretase activities and Abeta production. Neurobiology of Disease. 29: 422-37. PMID 18086530 DOI: 10.1016/J.Nbd.2007.10.005 |
0.475 |
|
| 2008 |
Zhang YW, Xu H. Molecular and cellular mechanisms for Alzheimer's disease: understanding APP metabolism. Current Molecular Medicine. 7: 687-96. PMID 18045146 DOI: 10.2174/156652407782564462 |
0.42 |
|
| 2008 |
Zhang H, Liu R, Wang R, Hong S, Xu H, Zhang Y. Presenilins regulate the cellular level of the tumor suppressor PTEN. Neurobiology of Aging. 29: 653-660. PMID 17222949 DOI: 10.1016/J.Neurobiolaging.2006.11.020 |
0.547 |
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| 2008 |
Xu H, Greenfield JP, Cai D, Leung LW, Kassik K, Rodriguez-Boulan E, Greengard P. Hormonal control of cerebral amyloidogenesis in Alzheimer's diseases Journal of Neurochemistry. 81: 82-82. DOI: 10.1046/J.1471-4159.81.S1.129.X |
0.617 |
|
| 2008 |
Xu H. S4-01-04: Identification and characterization of a novel gene that inhibits GSK3 activity and Abeta production Alzheimer's & Dementia. 4: T177-T178. DOI: 10.1016/J.Jalz.2008.05.475 |
0.344 |
|
| 2008 |
Leal MC, Bulloj A, Xu H, Castaño EM, Morelli L. P1-464: Exosome-dependent trafficking of insulin degrading enzyme modulates amyloid beta clearance Alzheimer's & Dementia. 4: T355-T356. DOI: 10.1016/J.Jalz.2008.05.1047 |
0.321 |
|
| 2007 |
Gandy S, Zhang YW, Ikin A, Schmidt SD, Bogush A, Levy E, Sheffield R, Nixon RA, Liao FF, Mathews PM, Xu H, Ehrlich ME. Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo. Journal of Neurochemistry. 102: 619-26. PMID 17630980 DOI: 10.1111/J.1471-4159.2007.04587.X |
0.487 |
|
| 2007 |
Zhang YW, Wang R, Liu Q, Zhang H, Liao FF, Xu H. Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression. Proceedings of the National Academy of Sciences of the United States of America. 104: 10613-8. PMID 17556541 DOI: 10.1073/Pnas.0703903104 |
0.444 |
|
| 2007 |
Li HL, Wang HH, Liu SJ, Deng YQ, Zhang YJ, Tian Q, Wang XC, Chen XQ, Yang Y, Zhang JY, Wang Q, Xu H, Liao FF, Wang JZ. Phosphorylation of tau antagonizes apoptosis by stabilizing beta-catenin, a mechanism involved in Alzheimer's neurodegeneration. Proceedings of the National Academy of Sciences of the United States of America. 104: 3591-6. PMID 17360687 DOI: 10.1073/Pnas.0609303104 |
0.477 |
|
| 2007 |
Lin P, Li F, Zhang YW, Huang H, Tong G, Farquhar MG, Xu H. Calnuc binds to Alzheimer's beta-amyloid precursor protein and affects its biogenesis. Journal of Neurochemistry. 100: 1505-14. PMID 17348862 DOI: 10.1111/J.1471-4159.2006.04336.X |
0.534 |
|
| 2007 |
Zhang X, Zhou K, Wang R, Cui J, Lipton SA, Liao FF, Xu H, Zhang YW. Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation. The Journal of Biological Chemistry. 282: 10873-80. PMID 17303576 DOI: 10.1074/Jbc.M608856200 |
0.412 |
|
| 2007 |
Xu H, Wang R, Zhang YW, Zhang X. Estrogen, beta-amyloid metabolism/trafficking, and Alzheimer's disease. Annals of the New York Academy of Sciences. 1089: 324-42. PMID 17261779 DOI: 10.1196/Annals.1386.036 |
0.527 |
|
| 2007 |
Gandy S, Zhang YW, Ikin A, Schmidt SD, Bogush A, Levy E, Sheffield R, Nixon RA, Liao F, Mathews PM, Xu H, Ehrlich ME. Erratum: Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo (Journal of Neurochemistry (2007) 102, (619-626)) Journal of Neurochemistry. 103. DOI: 10.1111/J.1471-4159.2007.04950.X |
0.428 |
|
| 2006 |
He G, Qing H, Cai F, Kwok C, Xu H, Yu G, Bernstein A, Song W. Ubiquitin-proteasome pathway mediates degradation of APH-1. Journal of Neurochemistry. 99: 1403-12. PMID 17059559 DOI: 10.1111/J.1471-4159.2006.04184.X |
0.484 |
|
| 2006 |
Zhang X, Zhang YW, Liu S, Bulloj A, Tong GG, Zhang Z, Liao FF, Xu H. Tumor suppressor PTEN affects tau phosphorylation: deficiency in the phosphatase activity of PTEN increases aggregation of an FTDP-17 mutant Tau. Molecular Neurodegeneration. 1: 7. PMID 16930454 DOI: 10.1186/1750-1326-1-7 |
0.403 |
|
| 2006 |
Vetrivel KS, Zhang YW, Xu H, Thinakaran G. Pathological and physiological functions of presenilins. Molecular Neurodegeneration. 1: 4. PMID 16930451 DOI: 10.1186/1750-1326-1-4 |
0.499 |
|
| 2006 |
Wang ZF, Li HL, Li XC, Zhang Q, Tian Q, Wang Q, Xu H, Wang JZ. Effects of endogenous beta-amyloid overproduction on tau phosphorylation in cell culture. Journal of Neurochemistry. 98: 1167-75. PMID 16762022 DOI: 10.1111/J.1471-4159.2006.03956.X |
0.47 |
|
| 2006 |
Zhang X, Li F, Bulloj A, Zhang YW, Tong G, Zhang Z, Liao FF, Xu H. Tumor-suppressor PTEN affects tau phosphorylation, aggregation, and binding to microtubules. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 1272-4. PMID 16645045 DOI: 10.1096/Fj.06-5721Fje |
0.494 |
|
| 2006 |
Wang R, Zhang YW, Sun P, Liu R, Zhang X, Zhang X, Xia K, Xia J, Xu H, Zhang Z. Transcriptional regulation of PEN-2, a key component of the gamma-secretase complex, by CREB. Molecular and Cellular Biology. 26: 1347-54. PMID 16449647 DOI: 10.1128/Mcb.26.4.1347-1354.2006 |
0.387 |
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| 2006 |
Cai D, Netzer WJ, Zhong M, Lin Y, Du G, Frohman M, Foster DA, Sisodia SS, Xu H, Gorelick FS, Greengard P. Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation. Proceedings of the National Academy of Sciences of the United States of America. 103: 1941-6. PMID 16449386 DOI: 10.1073/Pnas.0510708103 |
0.556 |
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| 2006 |
Cai D, Zhong M, Wang R, Netzer WJ, Shields D, Zheng H, Sisodia SS, Foster DA, Gorelick FS, Xu H, Greengard P. Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons. Proceedings of the National Academy of Sciences of the United States of America. 103: 1936-40. PMID 16449385 DOI: 10.1073/Pnas.0510710103 |
0.768 |
|
| 2006 |
Bulloj A, Leal MC, Morelli L, Xu H, Castaño E. P1-223: Active insulin degrading enzyme in lipid rafts: Relevance for Aβ degradation in the brain Alzheimer's & Dementia. 2: S161-S162. DOI: 10.1016/J.Jalz.2006.05.600 |
0.317 |
|
| 2006 |
Gandy S, Zhang Y, Ikin A, Schmidt S, Sheffield R, Nixon R, Liao F, Matthews P, Xu H, Ehrlich M. S4-03-01: Evidence that aberrant post-TGN trafficking of Alzheimer's APP is sufficient to elevate brain A-beta 42 and may underlie mutant presenilin action Alzheimer's & Dementia. 2: S71-S71. DOI: 10.1016/J.Jalz.2006.05.277 |
0.411 |
|
| 2006 |
Xiong H, Callaghan D, Jones A, Yam Y, Pei K, Walker D, Lue L, Woulfe J, Beach TG, Sue L, Stanimiorovic D, Xu H, Zhang W. P4-057: ABCG1/ABCG4-mediated cellular cholesterol efflux affects β-and γ-secretase activities and β-amyloid production in N2a cells Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.1795 |
0.349 |
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| 2005 |
Han P, Dou F, Li F, Zhang X, Zhang YW, Zheng H, Lipton SA, Xu H, Liao FF. Suppression of cyclin-dependent kinase 5 activation by amyloid precursor protein: a novel excitoprotective mechanism involving modulation of tau phosphorylation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 11542-52. PMID 16354912 DOI: 10.1523/Jneurosci.3831-05.2005 |
0.527 |
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| 2005 |
Zhang YW, Luo WJ, Wang H, Lin P, Vetrivel KS, Liao F, Li F, Wong PC, Farquhar MG, Thinakaran G, Xu H. Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components. The Journal of Biological Chemistry. 280: 17020-6. PMID 15711015 DOI: 10.1074/Jbc.M409467200 |
0.399 |
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| 2005 |
Li Z, Wang W, Zhou F, Gao X, Peng G, Xu H, Chen Y. Interaction of stathmin-like 2 protein with the APP intracellular domain Tsinghua Science and Technology. 10: 484-488. DOI: 10.1016/S1007-0214(05)70104-8 |
0.468 |
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| 2004 |
Vetrivel KS, Cheng H, Lin W, Sakurai T, Li T, Nukina N, Wong PC, Xu H, Thinakaran G. Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes. The Journal of Biological Chemistry. 279: 44945-54. PMID 15322084 DOI: 10.1074/Jbc.M407986200 |
0.387 |
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| 2004 |
Wang H, Luo WJ, Zhang YW, Li YM, Thinakaran G, Greengard P, Xu H. Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components. The Journal of Biological Chemistry. 279: 40560-6. PMID 15247291 DOI: 10.1074/Jbc.M404345200 |
0.44 |
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| 2004 |
Gasparini L, Rusconi L, Xu H, del Soldato P, Ongini E. Modulation of beta-amyloid metabolism by non-steroidal anti-inflammatory drugs in neuronal cell cultures. Journal of Neurochemistry. 88: 337-48. PMID 14690522 DOI: 10.1111/J.1471-4159.2004.02154.X |
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| 2003 |
Liu SJ, Zhang AH, Li HL, Wang Q, Deng HM, Netzer WJ, Xu H, Wang JZ. Overactivation of glycogen synthase kinase-3 by inhibition of phosphoinositol-3 kinase and protein kinase C leads to hyperphosphorylation of tau and impairment of spatial memory. Journal of Neurochemistry. 87: 1333-44. PMID 14713290 DOI: 10.1046/J.1471-4159.2003.02070.X |
0.441 |
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| 2003 |
Netzer WJ, Dou F, Cai D, Veach D, Jean S, Li Y, Bornmann WG, Clarkson B, Xu H, Greengard P. Gleevec inhibits beta-amyloid production but not Notch cleavage. Proceedings of the National Academy of Sciences of the United States of America. 100: 12444-9. PMID 14523244 DOI: 10.1073/Pnas.1534745100 |
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| 2003 |
Gasparini L, Xu H. Potential roles of insulin and IGF-1 in Alzheimer's disease. Trends in Neurosciences. 26: 404-6. PMID 12900169 DOI: 10.1016/S0166-2236(03)00163-2 |
0.38 |
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| 2003 |
Dou F, Netzer WJ, Tanemura K, Li F, Hartl FU, Takashima A, Gouras GK, Greengard P, Xu H. Chaperones increase association of tau protein with microtubules. Proceedings of the National Academy of Sciences of the United States of America. 100: 721-6. PMID 12522269 DOI: 10.1073/Pnas.242720499 |
0.58 |
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| 2003 |
Luo WJ, Wang H, Li H, Kim BS, Shah S, Lee HJ, Thinakaran G, Kim TW, Yu G, Xu H. PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1. The Journal of Biological Chemistry. 278: 7850-4. PMID 12522139 DOI: 10.1074/Jbc.C200648200 |
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| 2003 |
Cai D, Leem JY, Greenfield JP, Wang P, Kim BS, Wang R, Lopes KO, Kim SH, Zheng H, Greengard P, Sisodia SS, Thinakaran G, Xu H. Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein. The Journal of Biological Chemistry. 278: 3446-54. PMID 12435726 DOI: 10.1074/Jbc.M209065200 |
0.542 |
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| 2002 |
Leem JY, Saura CA, Pietrzik C, Christianson J, Wanamaker C, King LT, Veselits ML, Tomita T, Gasparini L, Iwatsubo T, Xu H, Green WN, Koo EH, Thinakaran G. A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface. Neurobiology of Disease. 11: 64-82. PMID 12460547 DOI: 10.1006/Nbdi.2002.0546 |
0.422 |
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| 2002 |
Takahashi RH, Milner TA, Li F, Nam EE, Edgar MA, Yamaguchi H, Beal MF, Xu H, Greengard P, Gouras GK. Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology. The American Journal of Pathology. 161: 1869-79. PMID 12414533 DOI: 10.1016/S0002-9440(10)64463-X |
0.594 |
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| 2002 |
Luo Y, Smith JV, Paramasivam V, Burdick A, Curry KJ, Buford JP, Khan I, Netzer WJ, Xu H, Butko P. Inhibition of amyloid-beta aggregation and caspase-3 activation by the Ginkgo biloba extract EGb761. Proceedings of the National Academy of Sciences of the United States of America. 99: 12197-202. PMID 12213959 DOI: 10.1073/Pnas.182425199 |
0.52 |
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| 2002 |
Gasparini L, Netzer WJ, Greengard P, Xu H. Does insulin dysfunction play a role in Alzheimer's disease? Trends in Pharmacological Sciences. 23: 288-93. PMID 12084635 DOI: 10.1016/S0165-6147(02)02037-0 |
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| 2002 |
Lu Z, Murray JT, Luo W, Li H, Wu X, Xu H, Backer JM, Chen YG. Transforming growth factor β activates Smad2 in the absence of receptor endocytosis Journal of Biological Chemistry. 277: 29363-29368. PMID 12034739 DOI: 10.1074/Jbc.M203495200 |
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| 2002 |
Leem JY, Vijayan S, Han P, Cai D, Machura M, Lopes KO, Veselits ML, Xu H, Thinakaran G. Presenilin 1 is required for maturation and cell surface accumulation of nicastrin. The Journal of Biological Chemistry. 277: 19236-40. PMID 11943765 DOI: 10.1074/Jbc.C200148200 |
0.45 |
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| 2002 |
Greenfield JP, Leung LW, Cai D, Kaasik K, Gross RS, Rodriguez-Boulan E, Greengard P, Xu H. Estrogen lowers Alzheimer beta-amyloid generation by stimulating trans-Golgi network vesicle biogenesis. The Journal of Biological Chemistry. 277: 12128-36. PMID 11823458 DOI: 10.1074/Jbc.M110009200 |
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| 2001 |
Yu C, Kim SH, Ikeuchi T, Xu H, Gasparini L, Wang R, Sisodia SS. Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains. The Journal of Biological Chemistry. 276: 43756-60. PMID 11583985 DOI: 10.1074/Jbc.C100410200 |
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| 2001 |
Yan R, Han P, Miao H, Greengard P, Xu H. The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate. The Journal of Biological Chemistry. 276: 36788-96. PMID 11466313 DOI: 10.1074/Jbc.M104350200 |
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| 2001 |
Gasparini L, Gouras GK, Wang R, Gross RS, Beal MF, Greengard P, Xu H. Stimulation of β-Amyloid Precursor Protein Trafficking by Insulin Reduces Intraneuronal β-Amyloid and Requires Mitogen-Activated Protein Kinase Signaling The Journal of Neuroscience. 21: 2561-2570. DOI: 10.1523/Jneurosci.21-08-02561.2001 |
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| 2000 |
Gouras GK, Xu H, Gross RS, Greenfield JP, Hai B, Wang R, Greengard P. Testosterone reduces neuronal secretion of Alzheimer's beta-amyloid peptides. Proceedings of the National Academy of Sciences of the United States of America. 97: 1202-5. PMID 10655508 DOI: 10.1073/Pnas.97.3.1202 |
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| 2000 |
Gouras GK, Tsai J, Naslund J, Vincent B, Edgar M, Checler F, Greenfield JP, Haroutunian V, Buxbaum JD, Xu H, Greengard P, Relkin NR. Intraneuronal Abeta42 accumulation in human brain. The American Journal of Pathology. 156: 15-20. PMID 10623648 DOI: 10.1016/S0002-9440(10)64700-1 |
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Gouras GK, Gross RS, Netzer WJ, Greenfield JP, Greengard P, Xu H. Intraneuronal β-amyloid with aging and alzheimer's disease Neurobiology of Aging. 21: 207. DOI: 10.1016/S0197-4580(00)83260-1 |
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Gasparini L, Gouras GK, Wang R, Gross RS, Beal M, Greengard P, Xu H. Insulin-regulated β-amyloid protein trafficking: Stimulated secretion and reduced intracellular accumulation of Aβ in neuronal cell cultures Neurobiology of Aging. 21: 183. DOI: 10.1016/S0197-4580(00)82165-X |
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| 1999 |
Greenfield JP, Xu H, Greengard P, Gandy S, Seeger M. Generation of the amyloid-beta peptide N terminus in Saccharomyces cerevisiae expressing human Alzheimer's amyloid-beta precursor protein. The Journal of Biological Chemistry. 274: 33843-6. PMID 10567340 DOI: 10.1074/Jbc.274.48.33843 |
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Greenfield JP, Tsai J, Gouras GK, Hai B, Thinakaran G, Checler F, Sisodia SS, Greengard P, Xu H. Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides. Proceedings of the National Academy of Sciences of the United States of America. 96: 742-7. PMID 9892704 DOI: 10.1073/Pnas.96.2.742 |
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Gouras GK, Xu H, Jovanovic JN, Buxbaum JD, Wang R, Greengard P, Relkin NR, Gandy S. Generation and regulation of beta-amyloid peptide variants by neurons. Journal of Neurochemistry. 71: 1920-5. PMID 9798916 DOI: 10.1046/J.1471-4159.1998.71051920.X |
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Xu H, Gouras GK, Greenfield JP, Vincent B, Naslund J, Mazzarelli L, Fried G, Jovanovic JN, Seeger M, Relkin NR, Liao F, Checler F, Buxbaum JD, Chait BT, Thinakaran G, et al. Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides. Nature Medicine. 4: 447-51. PMID 9546791 DOI: 10.1038/Nm0498-447 |
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Xu H, Sweeney D, Wang R, Thinakaran G, Lo AC, Sisodia SS, Greengard P, Gandy S. Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation. Proceedings of the National Academy of Sciences of the United States of America. 94: 3748-52. PMID 9108049 DOI: 10.1073/Pnas.94.8.3748 |
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| 1996 |
Müsch A, Xu H, Shields D, Rodriguez-Boulan E. Transport of vesicular stomatitis virus G protein to the cell surface is signal mediated in polarized and nonpolarized cells. The Journal of Cell Biology. 133: 543-58. PMID 8636230 DOI: 10.1083/Jcb.133.3.543 |
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Xu H, Sweeney D, Greengard P, Gandy S. Metabolism of Alzheimer beta-amyloid precursor protein: regulation by protein kinase A in intact cells and in a cell-free system. Proceedings of the National Academy of Sciences of the United States of America. 93: 4081-4. PMID 8633020 DOI: 10.1073/Pnas.93.9.4081 |
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Xu H, Sweeney D, Wang R, Sisodia S, Grecngard P, Gandy S. 323 Regulation of Alzheimer β-amyloid protein precursor metabolism in cell-free systems Neurobiology of Aging. 17: S81. DOI: 10.1016/S0197-4580(96)80325-3 |
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Gandy S, Xu H, Seeger M, Desdouits F, Sweeney D, Jaffe A, Toran-Allerand D, Frail D, Greengard P. 21 Regulated cleavage of amyloid-β precursor: Basic and clinical aspects Neurobiology of Aging. 17: S6. DOI: 10.1016/S0197-4580(96)80023-6 |
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Xu H, Greengard P, Gandy S. Regulated formation of Golgi secretory vesicles containing Alzheimer beta-amyloid precursor protein. The Journal of Biological Chemistry. 270: 23243-5. PMID 7559474 DOI: 10.1074/Jbc.270.40.23243 |
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Xu H, Shields D. Prohormone processing in the trans-Golgi network: endoproteolytic cleavage of prosomatostatin and formation of nascent secretory vesicles in permeabilized cells. The Journal of Cell Biology. 122: 1169-84. PMID 8104189 DOI: 10.1083/Jcb.122.6.1169 |
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