Rodney Lyle Johnson - Publications

Affiliations: 
1979- Medicinal Chemistry University of Minnesota, Twin Cities, Minneapolis, MN 
Area:
Peptidomimetics, dopamine receptors, allosteric modulators
Website:
https://www.pharmacy.umn.edu/bio/cop-experts/rodney-johnson

45 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Maize KM, Kurbanov EK, Johnson RL, Amin EA, Finzel BC. Ligand-induced expansion of the S1' site in the anthrax toxin lethal factor. Febs Letters. PMID 26578066 DOI: 10.1016/j.febslet.2015.11.005  1
2015 Kurbanov EK, Chiu TL, Solberg J, Francis S, Maize KM, Fernandez J, Johnson RL, Hawkinson JE, Walters MA, Finzel BC, Amin EA. Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates. Journal of Medicinal Chemistry. PMID 26492514 DOI: 10.1021/acs.jmedchem.5b01446  1
2015 Basu D, Tian Y, Hui P, Bhandari J, Johnson RL, Mishra RK. Change in expression of vesicular protein synapsin II by chronic treatment with D2 allosteric modulator PAOPA. Peptides. 66: 58-62. PMID 25703303 DOI: 10.1016/j.peptides.2015.01.004  1
2014 Maize KM, Kurbanov EK, De La Mora-Rey T, Geders TW, Hwang DJ, Walters MA, Johnson RL, Amin EA, Finzel BC. Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding. Acta Crystallographica. Section D, Biological Crystallography. 70: 2813-22. PMID 25372673 DOI: 10.1107/S1399004714018161  1
2013 Basu D, Tian Y, Bhandari J, Jiang JR, Hui P, Johnson RL, Mishra RK. Effects of the dopamine D2 allosteric modulator, PAOPA, on the expression of GRK2, arrestin-3, ERK1/2, and on receptor internalization. Plos One. 8: e70736. PMID 23940634 DOI: 10.1371/journal.pone.0070736  1
2013 Tan ML, Basu D, Kwiecien JM, Johnson RL, Mishra RK. Preclinical pharmacokinetic and toxicological evaluation of MIF-1 peptidomimetic, PAOPA: examining the pharmacology of a selective dopamine D2 receptor allosteric modulator for the treatment of schizophrenia. Peptides. 42: 89-96. PMID 23416534 DOI: 10.1016/j.peptides.2013.02.004  1
2013 Bhagwanth S, Mishra RK, Johnson RL. Development of peptidomimetic ligands of Pro-Leu-Gly-NH(2) as allosteric modulators of the dopamine D(2) receptor. Beilstein Journal of Organic Chemistry. 9: 204-14. PMID 23400263 DOI: 10.3762/bjoc.9.24  1
2013 Beyaert MG, Daya RP, Dyck BA, Johnson RL, Mishra RK. PAOPA, a potent dopamine D2 receptor allosteric modulator, prevents and reverses behavioral and biochemical abnormalities in an amphetamine-sensitized preclinical animal model of schizophrenia. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 23: 253-62. PMID 22658400 DOI: 10.1016/j.euroneuro.2012.04.010  1
2012 Bhagwanth S, Mishra S, Daya R, Mah J, Mishra RK, Johnson RL. Transformation of Pro-Leu-Gly-NH2 peptidomimetic positive allosteric modulators of the dopamine D2 receptor into negative modulators. Acs Chemical Neuroscience. 3: 274-84. PMID 22860194 DOI: 10.1021/cn200096u  1
2010 Mann A, Verma V, Basu D, Skoblenick KJ, Beyaert MG, Fisher A, Thomas N, Johnson RL, Mishra RK. Specific binding of photoaffinity-labeling peptidomimetics of Pro-Leu-Gly-NH2 to the dopamine D2L receptor: evidence for the allosteric modulation of the dopamine receptor. European Journal of Pharmacology. 641: 96-101. PMID 20639138 DOI: 10.1016/j.ejphar.2010.05.018  1
2010 Wood RL, Young-Dixon BJ, Roy A, Gay BC, Johnson RL, Amin EA. Evaluation of Density Functionals, SCC-DFTB, Neglect of Diatomic Differential Overlap (NDDO) Models and Molecular Mechanics Methods for Prolyl-Leucyl-Glycinamide (PLG) and Structural Derivatives. Theochem. 944: 76-82. PMID 20401321 DOI: 10.1016/j.theochem.2009.12.026  1
2009 Raghavan B, Skoblenick KJ, Bhagwanth S, Argintaru N, Mishra RK, Johnson RL. Allosteric modulation of the dopamine D2 receptor by Pro-Leu-Gly-NH2 peptidomimetics constrained in either a polyproline II helix or a type II beta-turn conformation. Journal of Medicinal Chemistry. 52: 2043-51. PMID 19271750 DOI: 10.1021/jm801575w  1
2007 Vartak AP, Skoblenick K, Thomas N, Mishra RK, Johnson RL. Allosteric modulation of the dopamine receptor by conformationally constrained type VI beta-turn peptidomimetics of Pro-Leu-Gly-NH2. Journal of Medicinal Chemistry. 50: 6725-9. PMID 18052024 DOI: 10.1021/jm070895r  1
2007 Castellano JM, Batrynchuk J, Dolbeare K, Verma V, Mann A, Skoblenick KJ, Johnson RL, Mishra RK. MIF-1 and its peptidomimetic analogs attenuate haloperidol-induced vacuous chewing movements and modulate apomorphine-induced rotational behavior in 6-hydroxydopamine-lesioned rats. Peptides. 28: 2009-15. PMID 17766011 DOI: 10.1016/j.peptides.2007.07.026  1
2006 Raghavan B, Johnson RL. Short stereoselective synthesis of α-substituted γ-lactams Journal of Organic Chemistry. 71: 2151-2154. PMID 16497007 DOI: 10.1021/jo052212q  1
2006 Vartak AP, Johnson RL. Concerted synthesis of a spirobicyclic type-VI beta-turn mimic of Pro-Pro-Pro-NH2. Organic Letters. 8: 983-6. PMID 16494490 DOI: 10.1021/ol0600335  1
2006 Fisher A, Mann A, Verma V, Thomas N, Mishra RK, Johnson RL. Design and synthesis of photoaffinity-labeling ligands of the L-prolyl-L-leucylglycinamide binding site involved in the allosteric modulation of the dopamine receptor. Journal of Medicinal Chemistry. 49: 307-17. PMID 16392815 DOI: 10.1021/jm050644n  1
2005 Verma V, Mann A, Costain W, Pontoriero G, Castellano JM, Skoblenick K, Gupta SK, Pristupa Z, Niznik HB, Johnson RL, Nair VD, Mishra RK. Modulation of agonist binding to human dopamine receptor subtypes by L-prolyl-L-leucyl-glycinamide and a peptidomimetic analog. The Journal of Pharmacology and Experimental Therapeutics. 315: 1228-36. PMID 16126839 DOI: 10.1124/jpet.105.091256  1
2005 Somu RV, Johnson RL. Synthesis of pipecolic acid-based spiro bicyclic lactam scaffolds as beta-turn mimics. The Journal of Organic Chemistry. 70: 5954-63. PMID 16018691 DOI: 10.1021/jo050529k  0.01
2005 Vartak AP, Young VG, Johnson RL. Stereoselective synthesis of alpha,alpha'-biprolines. Organic Letters. 7: 35-8. PMID 15624971 DOI: 10.1021/ol047958+  1
2005 Johnson RL, Rao KS. 2,3-Ethylene- and 2,3-trimethylene-bridged analogues of the group III metabotropic glutamate receptor ligand 2-amino-4-phosphonobutanoic acid. Bioorganic & Medicinal Chemistry Letters. 15: 57-60. PMID 15582410 DOI: 10.1016/j.bmcl.2004.10.040  0.01
2003 Dolbeare K, Pontoriero GF, Gupta SK, Mishra RK, Johnson RL. Iso-lactam and reduced amide analogues of the peptidomimetic dopamine receptor modulator 3(R)-[(2(S)-pyrrolidinylcarbonyl)amino]-2-oxo-1-pyrrolidineacetamide. Bioorganic & Medicinal Chemistry. 11: 4103-12. PMID 12927872  1
2003 Dolbeare K, Pontoriero GF, Gupta SK, Mishra RK, Johnson RL. Synthesis and dopamine receptor modulating activity of 3-substituted gamma-lactam peptidomimetics of L-prolyl-L-leucyl-glycinamide. Journal of Medicinal Chemistry. 46: 727-33. PMID 12593653 DOI: 10.1021/jm020441o  1
1999 Baures PW, Pradhan A, Ojala WH, Gleason WB, Mishra RK, Johnson RL. Synthesis and dopamine receptor modulating activity of unsubstituted and substituted triproline analogues of L-prolyl-L-leucyl-glycinamide (PLG). Bioorganic & Medicinal Chemistry Letters. 9: 2349-52. PMID 10476867 DOI: 10.1016/S0960-894X(99)00386-8  1
1999 Khalil EM, Pradhan A, Ojala WH, Gleason WB, Mishra RK, Johnson RL. Synthesis and dopamine receptor modulating activity of substituted bicyclic thiazolidine lactam peptidomimetics of L-prolyl-L-leucyl-glycinamide. Journal of Medicinal Chemistry. 42: 2977-87. PMID 10425107 DOI: 10.1021/jm990140n  1
1999 Littman L, Tokar C, Venkatraman S, Roon RJ, Koerner JF, Robinson MB, Johnson RL. Cyclobutane quisqualic acid analogues as selective mGluR5a metabotropic glutamic acid receptor ligands. Journal of Medicinal Chemistry. 42: 1639-47. PMID 10229632 DOI: 10.1021/jm9806897  1
1999 Evans MC, Pradhan A, Venkatraman S, Ojala WH, Gleason WB, Mishra RK, Johnson RL. Synthesis and dopamine receptor modulating activity of novel peptidomimetics of L-prolyl-L-leucyl-glycinamide featuring alpha,alpha-disubstituted amino acids. Journal of Medicinal Chemistry. 42: 1441-7. PMID 10212130 DOI: 10.1021/jm980656r  1
1999 Khalil EM, Ojala WH, Pradhan A, Nair VD, Gleason WB, Mishra RK, Johnson RL. Design, synthesis, and dopamine receptor modulating activity of spiro bicyclic peptidomimetics of L-prolyl-L-leucyl-glycinamide. Journal of Medicinal Chemistry. 42: 628-37. PMID 10052970 DOI: 10.1021/jm980525q  1
1997 Baures PW, Ojala WH, Costain WJ, Ott MC, Pradhan A, Gleason WB, Mishra RK, Johnson RL. Design, synthesis, and dopamine receptor modulating activity of diketopiperazine peptidomimetics of L-prolyl-L-leucylglycinamide. Journal of Medicinal Chemistry. 40: 3594-600. PMID 9357526 DOI: 10.1021/jm970328b  1
1997 Baures PW, Ojala WH, Gleason WB, Johnson RL. Conformational analysis of homochiral and heterochiral diprolines as beta-turn-forming peptidomimetics: unsubstituted and substituted models. The Journal of Peptide Research : Official Journal of the American Peptide Society. 50: 1-13. PMID 9273882  1
1994 Venkatraman S, Roon RJ, Schulte MK, Koerner JF, Johnson RL. Synthesis of oxadiazolidinedione derivatives as quisqualic acid analogues and their evaluation at a quisqualate-sensitized site in the rat hippocampus. Journal of Medicinal Chemistry. 37: 3939-46. PMID 7966155  1
1994 Baures PW, Ojala WH, Gleason WB, Mishra RK, Johnson RL. Design, synthesis, X-ray analysis, and dopamine receptor-modulating activity of mimics of the "C5" hydrogen-bonded conformation in the peptidomimetic 2-oxo-3(R)-[(2(S)-pyrrolidinylcarbonyl)amino]-1- pyrrolidineacetamide. Journal of Medicinal Chemistry. 37: 3677-83. PMID 7966127 DOI: 10.1021/jm00048a003  1
1993 Subasinghe NL, Bontems RJ, McIntee E, Mishra RK, Johnson RL. Bicyclic thiazolidine lactam peptidomimetics of the dopamine receptor modulating peptide Pro-Leu-Gly-NH2. Journal of Medicinal Chemistry. 36: 2356-61. PMID 8103113  1
1993 Sreenivasan U, Mishra RK, Johnson RL. Synthesis and dopamine receptor modulating activity of lactam conformationally constrained analogues of Pro-Leu-Gly-NH2. Journal of Medicinal Chemistry. 36: 256-63. PMID 8093736  1
1993 Genin MJ, Mishra RK, Johnson RL. Dopamine receptor modulation by a highly rigid spiro bicyclic peptidomimetic of Pro-Leu-Gly-NH2. Journal of Medicinal Chemistry. 36: 3481-3. PMID 7901418  1
1992 Peterson NL, Kroona HB, Johnson RL, Koerner JF. Activity of the conformationally rigid 2-amino-4-phosphonobutanoic acid (AP4) analogue (RS)-1-amino-3-(phosphonomethylene)cyclobutane-1-carboxylic acid (cyclobutylene AP5) on evoked responses in the perforant pathway of rat hippocampus. Brain Research. 571: 162-4. PMID 1611490 DOI: 10.1016/0006-8993(92)90525-E  1
1992 Subasinghe N, Schulte M, Roon RJ, Koerner JF, Johnson RL. Quisqualic acid analogues: synthesis of beta-heterocyclic 2-aminopropanoic acid derivatives and their activity at a novel quisqualate-sensitized site. Journal of Medicinal Chemistry. 35: 4602-7. PMID 1469691  1
1991 Kroona HB, Peterson NL, Koerner JF, Johnson RL. Synthesis of the 2-amino-4-phosphonobutanoic acid analogues (E)- and (Z)-2-amino-2,3-methano-4-phosphonobutanoic acid and their evaluation as inhibitors of hippocampal excitatory neurotransmission. Journal of Medicinal Chemistry. 34: 1692-9. PMID 1674540  1
1991 Peterson NL, Thoreson WB, Johnson RL, Koerner JF, Miller RF. Characterization of retinal and hippocampal L-AP4 receptors using conformationally constrained AP4 analogues. Brain Research. 568: 15-23. PMID 1667614 DOI: 10.1016/0006-8993(91)91374-A  1
1990 Subasinghe N, Schulte M, Chan MY, Roon RJ, Koerner JF, Johnson RL. Synthesis of acyclic and dehydroaspartic acid analogues of Ac-Asp-Glu-OH and their inhibition of rat brain N-acetylated alpha-linked acidic dipeptidase (NAALA dipeptidase). Journal of Medicinal Chemistry. 33: 2734-44. PMID 2213826  1
1990 Johnson RL, Bontems RJ, Yang KE, Mishra RK. Synthesis and biological evaluation of analogues of Pro-Leu-Gly-NH2 modified at the leucyl residue. Journal of Medicinal Chemistry. 33: 1828-32. PMID 1971310  1
1988 Yu KL, Rajakumar G, Srivastava LK, Mishra RK, Johnson RL. Dopamine receptor modulation by conformationally constrained analogues of Pro-Leu-Gly-NH2. Journal of Medicinal Chemistry. 31: 1430-6. PMID 3385734  1
1988 Johnson RL, Koerner JF. Excitatory amino acid neurotransmission. Journal of Medicinal Chemistry. 31: 2057-66. PMID 2846835  1
1987 Clements JR, Madl JE, Johnson RL, Larson AA, Beitz AJ. Localization of glutamate, glutaminase, aspartate and aspartate aminotransferase in the rat midbrain periaqueductal gray. Experimental Brain Research. 67: 594-602. PMID 2888681 DOI: 10.1007/BF00247290  1
1978 Johnson RL, Smissman EE, Plotnikoff NP. Study of the structural requirements for dopa potentiation and oxotremorine antagonism by L-prolyl-L-leucylglycinamide. Journal of Medicinal Chemistry. 21: 165-9. PMID 23433  0.72
Show low-probability matches.