Christie Brouillette - Publications

Chemistry University of Alabama, Birmingham, Birmingham, AL, United States 
Protein Structural Cooperativity and Energetics, Biophysics, Antibacterial Drug Discovery

43 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Wang C, Aleksandrov AA, Yang Z, Forouhar F, Proctor EA, Kota P, An J, Kaplan A, Khazanov N, Boël G, Stockwell BR, Senderowitz H, Dokholyan NV, Riordan JR, Brouillette CG, et al. Ligand binding to a remote site thermodynamically corrects the F508del mutation in the human cystic fibrosis transmembrane conductance regulator. The Journal of Biological Chemistry. PMID 29903914 DOI: 10.1074/jbc.RA117.000819  1
2018 Yang Z, Hildebrandt E, Jiang F, Aleksandrov AA, Khazanov N, Zhou Q, An J, Mezzell AT, Xavier BM, Ding H, Riordan JR, Senderowitz H, Kappes JC, Brouillette CG, Urbatsch IL. Structural stability of purified human CFTR is systematically improved by mutations in nucleotide binding domain 1. Biochimica Et Biophysica Acta. PMID 29425673 DOI: 10.1016/j.bbamem.2018.02.006  1
2017 Vernon RM, Chong PA, Lin H, Yang Z, Zhou Q, Aleksandrov AA, Dawson JE, Riordan JR, Brouillette CG, Thibodeau PH, Forman-Kay JD. Stabilization of a nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator yields insight into disease-causing mutations. The Journal of Biological Chemistry. PMID 28655774 DOI: 10.1074/jbc.M116.772335  1
2017 Hudson RP, Dawson JE, Chong PA, Yang Z, Millen L, Thomas PJ, Brouillette CG, Forman-Kay JD. Direct Binding of the Corrector VX-809 to human CFTR NBD1: Evidence of an Allosteric Coupling between the Binding Site and the NBD1:CL4 interface. Molecular Pharmacology. PMID 28546419 DOI: 10.1124/mol.117.108373  1
2016 Yang Z, Zhou Q, Mok L, Singh A, Swartz DJ, Urbatsch IL, Brouillette CG. Interactions and cooperativity between P-glycoprotein structural domains determined by thermal unfolding provides insights into its solution structure and function. Biochimica Et Biophysica Acta. PMID 27783926 DOI: 10.1016/j.bbamem.2016.10.009  1
2016 Yang Z, Brouillette CG. A Guide to Differential Scanning Calorimetry of Membrane and Soluble Proteins in Detergents. Methods in Enzymology. 567: 319-58. PMID 26794360 DOI: 10.1016/bs.mie.2015.08.014  1
2015 He L, Aleksandrov AA, An J, Cui L, Yang Z, Brouillette CG, Riordan JR. Restoration of NBD1 thermal stability is necessary and sufficient to correct ∆F508 CFTR folding and assembly. Journal of Molecular Biology. 427: 106-20. PMID 25083918 DOI: 10.1016/j.jmb.2014.07.026  1
2014 Yang Z, Wang C, Zhou Q, An J, Hildebrandt E, Aleksandrov LA, Kappes JC, DeLucas LJ, Riordan JR, Urbatsch IL, Hunt JF, Brouillette CG. Membrane protein stability can be compromised by detergent interactions with the extramembranous soluble domains. Protein Science : a Publication of the Protein Society. 23: 769-89. PMID 24652590 DOI: 10.1002/pro.2460  1
2012 Hudson RP, Chong PA, Protasevich II, Vernon R, Noy E, Bihler H, An JL, Kalid O, Sela-Culang I, Mense M, Senderowitz H, Brouillette CG, Forman-Kay JD. Conformational changes relevant to channel activity and folding within the first nucleotide binding domain of the cystic fibrosis transmembrane conductance regulator. The Journal of Biological Chemistry. 287: 28480-94. PMID 22722932 DOI: 10.1074/jbc.M112.371138  1
2011 Bai J, Swartz DJ, Protasevich II, Brouillette CG, Harrell PM, Hildebrandt E, Gasser B, Mattanovich D, Ward A, Chang G, Urbatsch IL. A gene optimization strategy that enhances production of fully functional P-glycoprotein in Pichia pastoris. Plos One. 6: e22577. PMID 21826197 DOI: 10.1371/journal.pone.0022577  1
2010 Wang C, Protasevich I, Yang Z, Seehausen D, Skalak T, Zhao X, Atwell S, Emtage JS, Wetmore DR, Brouillette CG, Hunt JF. Integrated biophysical studies implicate partial unfolding of NBD1 of CFTR in the molecular pathogenesis of F508del cystic fibrosis Protein Science. 19: 1932-1947. PMID 20687163 DOI: 10.1002/pro.480  1
2010 Protasevich I, Yang Z, Wang C, Atwell S, Zhao X, Emtage S, Wetmore D, Hunt JF, Brouillette CG. Thermal unfolding studies show the disease causing F508del mutation in CFTR thermodynamically destabilizes nucleotide-binding domain 1 Protein Science. 19: 1917-1931. PMID 20687133 DOI: 10.1002/pro.479  1
2010 Atwell S, Brouillette CG, Conners K, Emtage S, Gheyi T, Guggino WB, Hendle J, Hunt JF, Lewis HA, Lu F, Protasevich II, Rodgers LA, Romero R, Wasserman SR, Weber PC, et al. Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant. Protein Engineering, Design & Selection : Peds. 23: 375-84. PMID 20150177 DOI: 10.1093/protein/gzq004  1
2009 Moro WB, Yang Z, Kane TA, Zhou Q, Harville S, Brouillette CG, Brouillette WJ. SAR studies for a new class of antibacterial NAD biosynthesis inhibitors. Journal of Combinatorial Chemistry. 11: 617-25. PMID 19408950 DOI: 10.1021/cc9000357  1
2009 Moro WB, Yang Z, Kane TA, Brouillette CG, Brouillette WJ. Virtual screening to identify lead inhibitors for bacterial NAD synthetase (NADs). Bioorganic & Medicinal Chemistry Letters. 19: 2001-5. PMID 19249205 DOI: 10.1016/j.bmcl.2009.02.034  1
2008 Lu S, Smith CD, Yang Z, Pruett PS, Nagy L, McCombs D, Delucas LJ, Brouillette WJ, Brouillette CG. Structure of nicotinic acid mononucleotide adenylyltransferase from Bacillus anthracis. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 64: 893-8. PMID 18931430 DOI: 10.1107/S1744309108029102  1
2007 McDonald HM, Pruett PS, Deivanayagam C, Protasevich II, Carson WM, DeLucas LJ, Brouillette WJ, Brouillette CG. Structural adaptation of an interacting non-native C-terminal helical extension revealed in the crystal structure of NAD+ synthetase from Bacillus anthracis. Acta Crystallographica. Section D, Biological Crystallography. 63: 891-905. PMID 17642516 DOI: 10.1107/S0907444907029769  1
2007 Velu SE, Mou L, Luan CH, Yang ZW, DeLucas LJ, Brouillette CG, Brouillette WJ. Antibacterial nicotinamide adenine dinucleotide synthetase inhibitors: amide- and ether-linked tethered dimers with alpha-amino acid end groups. Journal of Medicinal Chemistry. 50: 2612-21. PMID 17489580 DOI: 10.1021/jm061349l  1
2007 Carson M, Johnson DH, McDonald H, Brouillette C, Delucas LJ. His-tag impact on structure. Acta Crystallographica. Section D, Biological Crystallography. 63: 295-301. PMID 17327666 DOI: 10.1107/S0907444906052024  1
2005 Brouillette CG, Dong WJ, Yang ZW, Ray MJ, Protasevich II, Cheung HC, Engler JA. Förster resonance energy transfer measurements are consistent with a helical bundle model for lipid-free apolipoprotein A-I. Biochemistry. 44: 16413-25. PMID 16342934 DOI: 10.1021/bi051018v  1
2005 Velu SE, Luan CH, Delucas LJ, Brouillette CG, Brouillette WJ. Tethered dimer inhibitors of NAD synthetase: parallel synthesis of an aryl-substituted SAR library. Journal of Combinatorial Chemistry. 7: 898-904. PMID 16283799 DOI: 10.1021/cc050063j  1
2005 Ren X, Zhao L, Sivashanmugam A, Miao Y, Korando L, Yang Z, Reardon CA, Getz GS, Brouillette CG, Jerome WG, Wang J. Engineering mouse apolipoprotein A-I into a monomeric, active protein useful for structural determination. Biochemistry. 44: 14907-19. PMID 16274238 DOI: 10.1021/bi0508385  1
2004 Protasevich II, Brouillette CG, Snow ME, Dunham S, Rubin JR, Gogliotti R, Siegel K. Role of inhibitor aliphatic chain in the thermodynamics of inhibitor binding to Escherichia coli enoyl-ACP reductase and the Phe203Leu mutant: a proposed mechanism for drug resistance. Biochemistry. 43: 13380-9. PMID 15491144 DOI: 10.1021/bi0492509  1
2004 Yang ZW, Tendian SW, Carson WM, Brouillette WJ, Delucas LJ, Brouillette CG. Dimethyl sulfoxide at 2.5% (v/v) alters the structural cooperativity and unfolding mechanism of dimeric bacterial NAD+ synthetase. Protein Science : a Publication of the Protein Society. 13: 830-41. PMID 14978314 DOI: 10.1110/ps.03330104  1
2003 Chesnokova LS, Slepenkov SV, Protasevich II, Sehorn MG, Brouillette CG, Witt SN. Deletion of DnaK's lid strengthens binding to the nucleotide exchange factor, GrpE: a kinetic and thermodynamic analysis. Biochemistry. 42: 9028-40. PMID 12885236 DOI: 10.1021/bi0346493  1
2003 Velu SE, Cristofoli WA, Garcia GJ, Brouillette CG, Pierson MC, Luan CH, DeLucas LJ, Brouillette WJ. Tethered dimers as NAD synthetase inhibitors with antibacterial activity. Journal of Medicinal Chemistry. 46: 3371-81. PMID 12852767 DOI: 10.1021/jm030003x  1
2002 Symersky J, Devedjiev Y, Moore K, Brouillette C, DeLucas L. NH3-dependent NAD+ synthetase from Bacillus subtilis at 1 A resolution. Acta Crystallographica. Section D, Biological Crystallography. 58: 1138-46. PMID 12077433  1
2001 Parker MH, Brouillette CG, Prevelige PE. Kinetic and calorimetric evidence for two distinct scaffolding protein binding populations within the bacteriophage P22 procapsid Biochemistry. 40: 8962-8970. PMID 11467958 DOI: 10.1021/bi0026167  1
2001 Devedjiev Y, Symersky J, Singh R, Jedrzejas M, Brouillette C, Brouillette W, Muccio D, Chattopadhyay D, DeLucas L. Stabilization of active-site loops in NH3-dependent NAD+ synthetase from Bacillus subtilis. Acta Crystallographica. Section D, Biological Crystallography. 57: 806-12. PMID 11375500 DOI: 10.1107/S0907444901003523  1
2001 Brouillette CG, Anantharamaiah GM, Engler JA, Borhani DW. Structural models of human apolipoprotein A-I: a critical analysis and review. Biochimica Et Biophysica Acta. 1531: 4-46. PMID 11278170 DOI: 10.1016/S1388-1981(01)00081-6  1
2000 Parker MH, Ortwine DF, O'Brien PM, Lunney EA, Banotai CA, Mueller WT, McConnell P, Brouillette CG. Stereoselective binding of an enantiomeric pair of stromelysin-1 inhibitors caused by conformational entropy factors. Bioorganic & Medicinal Chemistry Letters. 10: 2427-30. PMID 11078193 DOI: 10.1016/S0960-894X(00)00495-9  1
2000 Zaliauskiene L, Kang S, Brouillette CG, Lebowitz J, Arani RB, Collawn JF. Down-regulation of cell surface receptors is modulated by polar residues within the transmembrane domain. Molecular Biology of the Cell. 11: 2643-55. PMID 10930460  1
1999 Parker MH, Lunney EA, Ortwine DF, Pavlovsky AG, Humblet C, Brouillette CG. Analysis of the binding of hydroxamic acid and carboxylic acid inhibitors to the stromelysin-1 (matrix metalloproteinase-3) catalytic domain by isothermal titration calorimetry. Biochemistry. 38: 13592-601. PMID 10521266 DOI: 10.1021/BI991222G  1
1998 Rogers DP, Roberts LM, Lebowitz J, Datta G, Anantharamaiah GM, Engler JA, Brouillette CG. The lipid-free structure of apolipoprotein A-I: effects of amino-terminal deletions. Biochemistry. 37: 11714-25. PMID 9718294 DOI: 10.1021/bi973112k  1
1998 Rogers DP, Roberts LM, Lebowitz J, Engler JA, Brouillette CG. Structural analysis of apolipoprotein A-I: effects of amino- and carboxy-terminal deletions on the lipid-free structure. Biochemistry. 37: 945-55. PMID 9454585 DOI: 10.1021/bi9713512  1
1993 Kappes JC, Parkin JS, Conway JA, Kim J, Brouillette CG, Shaw GM, Hahn BH. Intracellular Transport and Virion Incorporation of vpx Requires Interaction with Other Virus Type-Specific Components Virology. 193: 222-233. PMID 8438567 DOI: 10.1006/viro.1993.1118  1
1992 Muccio DD, Waterhous DV, Fish F, Brouillette CG. Analysis of the two-state behavior of the thermal unfolding of serum retinol binding protein containing a single retinol ligand Biochemistry®. 31: 5560-5567. PMID 1610801  1
1990 Anantharamaiah GM, Venkatachalapathi YV, Brouillette CG, Segrest JP. Use of synthetic peptide analogues to localize lecithin:cholesterol acyltransferase activating domain in apolipoprotein A-I. Arteriosclerosis (Dallas, Tex.). 10: 95-105. PMID 2105091  1
1989 Brouillette CG, McMichens RB, Stern LJ, Khorana HG. Structure and thermal stability of monomeric bacteriorhodopsin in mixed phospholipid/detergent micelles. Proteins. 5: 38-46. PMID 2748571 DOI: 10.1002/prot.340050106  1
1989 Chung BH, Segrest JP, Smith K, Griffin FM, Brouillette CG. Lipolytic surface remnants of triglyceride-rich lipoproteins are cytotoxic to macrophages but not in the presence of high density lipoprotein. A possible mechanism of atherogenesis? The Journal of Clinical Investigation. 83: 1363-74. PMID 2703536 DOI: 10.1172/JCI114024  1
1987 Brouillette CG, Muccio DD, Finney TK. PH dependence of bacteriorhodopsin thermal unfolding Biochemistry. 26: 7431-7438. PMID 3427085  1
1979 Brouillette CB, Chang CT, Mertes MP. 5-(alpha-Bromoacetyl)-2'-deoxyuridine 5'-phosphate: an affinity label for thymidylate synthetase. Journal of Medicinal Chemistry. 22: 1541-4. PMID 119854  1
1979 Brouillette CB, Chang CT, Mertes MP. 5 (alpha-bromoacetyl)-2'=deoxyuridine 5'-phosphate: a mechanism based affinity label for thymidylate synthetase. Biochemical and Biophysical Research Communications. 87: 613-8. PMID 109088 DOI: 10.1016/0006-291X(79)91838-2  1
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