Ernst ter Haar, Ph.D. - Publications

Affiliations: 
Vertex Pharmaceuticals, Boston, MA, United States 
Area:
crystallography

22 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Capoferri L, Leth R, Ter Haar E, Mohanty AK, Grootenhuis PD, Vottero E, Commandeur JN, Vermeulen NP, Jørgensen FS, Olsen L, Geerke DP. Insights into regioselective metabolism of mefenamic acid by Cytochrome P450 BM3 mutants through crystallography, docking, molecular dynamics, and free energy calculations. Proteins. PMID 26757175 DOI: 10.1002/prot.24985  1
2010 ter Haar E, Koth CM, Abdul-Manan N, Swenson L, Coll JT, Lippke JA, Lepre CA, Garcia-Guzman M, Moore JM. Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism. Structure (London, England : 1993). 18: 1083-93. PMID 20826335 DOI: 10.1016/j.str.2010.05.014  1
2009 Aronov AM, Tang Q, Martinez-Botella G, Bemis GW, Cao J, Chen G, Ewing NP, Ford PJ, Germann UA, Green J, Hale MR, Jacobs M, Janetka JW, Maltais F, Markland W, ... ... ter Haar E, et al. Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control. Journal of Medicinal Chemistry. 52: 6362-8. PMID 19827834 DOI: 10.1021/jm900630q  1
2007 ter Haar E, Prabhakar P, Prabakhar P, Liu X, Lepre C. Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer. The Journal of Biological Chemistry. 282: 9733-9. PMID 17255097 DOI: 10.1074/jbc.M611165200  1
2006 Ter Haar E. The Crystal Structures of Glycogen Synthase Kinase 3 Glycogen Synthase Kinase 3 (Gsk-3) and Its Inhibitors: Drug Discovery and Development. 61-82. DOI: 10.1002/9780470052174.ch4  1
2005 Pierce AC, ter Haar E, Binch HM, Kay DP, Patel SR, Li P. CH...O and CH...N hydrogen bonds in ligand design: a novel quinazolin-4-ylthiazol-2-ylamine protein kinase inhibitor. Journal of Medicinal Chemistry. 48: 1278-81. PMID 15715498 DOI: 10.1021/jm0492249  1
2004 ter Haar E, Walters WP, Pazhanisamy S, Taslimi P, Pierce AC, Bemis GW, Salituro FG, Harbeson SL. Kinase chemogenomics: targeting the human kinome for target validation and drug discovery. Mini Reviews in Medicinal Chemistry. 4: 235-53. PMID 15032672 DOI: 10.2174/1389557043487367  1
2003 ter Haar E. Activating MAP KAP kinase 2. Structure (London, England : 1993). 11: 611-2. PMID 12791249 DOI: 10.1016/S0969-2126(03)00104-7  1
2001 ter Haar E, Coll JT, Austen DA, Hsiao HM, Swenson L, Jain J. Structure of GSK3beta reveals a primed phosphorylation mechanism. Nature Structural Biology. 8: 593-6. PMID 11427888 DOI: 10.1038/89624  1
2000 ter Haar E, Harrison SC, Kirchhausen T. Peptide-in-groove interactions link target proteins to the beta-propeller of clathrin. Proceedings of the National Academy of Sciences of the United States of America. 97: 1096-100. PMID 10655490 DOI: 10.1073/pnas.97.3.1096  1
1999 Balachandran R, ter Haar E, Yalowich JC, Welsh MJ, Grant SG, Day BW. Induction of human breast cancer cell apoptosis from G2/M preceded by stimulation into the cell cycle by Z-1,1-dichloro-2,3-diphenylcyclopropane. Biochemical Pharmacology. 57: 97-110. PMID 9920290 DOI: 10.1016/S0006-2952(98)00289-5  1
1998 ter Haar E, Musacchio A, Harrison SC, Kirchhausen T. Atomic structure of clathrin: a beta propeller terminal domain joins an alpha zigzag linker. Cell. 95: 563-73. PMID 9827808 DOI: 10.1016/S0092-8674(00)81623-2  1
1998 Balachandran R, ter Haar E, Welsh MJ, Grant SG, Day BW. The potent microtubule-stabilizing agent (+)-discodermolide induces apoptosis in human breast carcinoma cells--preliminary comparisons to paclitaxel. Anti-Cancer Drugs. 9: 67-76. PMID 9491794 DOI: 10.1097/00001813-199801000-00008  1
1998 ter Haar E. Taxanes and other microtubule stabilising agents Expert Opinion On Therapeutic Patents. 8: 571-586. DOI: 10.1517/13543776.8.5.571  1
1997 Cupers P, ter Haar E, Boll W, Kirchhausen T. Parallel dimers and anti-parallel tetramers formed by epidermal growth factor receptor pathway substrate clone 15. The Journal of Biological Chemistry. 272: 33430-4. PMID 9407139 DOI: 10.1074/jbc.272.52.33430  1
1997 ter Haar E, Hamel E, Balachandran R, Day BW. Cellular targets of the anti-breast cancer agent Z-1,1-dichloro-2,3-diphenylcyclopropane: type II estrogen binding sites and tubulin. Anticancer Research. 17: 1861-9. PMID 9216636  1
1997 Jonnalagadda SS, ter Haar E, Hamel E, Lin CM, Magarian RA, Day BW. Synthesis and biological evaluation of 1,1-dichloro-2,3-diarylcyclopropanes as antitubulin and anti-breast cancer agents. Bioorganic & Medicinal Chemistry. 5: 715-22. PMID 9158870 DOI: 10.1016/S0968-0896(97)00014-X  1
1996 ter Haar E, Rosenkranz HS, Hamel E, Day BW. Computational and molecular modeling evaluation of the structural basis for tubulin polymerization inhibition by colchicine site agents. Bioorganic & Medicinal Chemistry. 4: 1659-71. PMID 8931935 DOI: 10.1016/0968-0896(96)00158-7  1
1996 ter Haar E, Day BW. Cytostatic and cytotoxic action of Z-1, 1-dichloro-2,3-diphenylcyclopropane in three human breast cancer cell lines. Anticancer Research. 16: 1107-15. PMID 8702221  1
1996 ter Haar E, Day BW, Rosenkranz HS. Direct tubulin polymerization perturbation contributes significantly to the induction of micronuclei in vivo. Mutation Research. 350: 331-7. PMID 8600362 DOI: 10.1016/0027-5107(95)00175-1  1
1996 ter Haar E, Kowalski RJ, Hamel E, Lin CM, Longley RE, Gunasekera SP, Rosenkranz HS, Day BW. Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol. Biochemistry. 35: 243-50. PMID 8555181 DOI: 10.1021/bi9515127  1
1996 ter Haar E, van Woerkens CMCM. Thermal links in high fields and low temperatures Czechoslovak Journal of Physics. 46: 2731-2732. DOI: 10.1007/BF02570352  0.01
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