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David J. Hartshorne - Publications

Affiliations: 
Nutritional Sciences University of Arizona, Tucson, AZ 
Website:
https://nutrition.cals.arizona.edu/people/david-hartshorne-phd

141 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Taniguchi M, Okamoto R, Ito M, Goto I, Fujita S, Konishi K, Mizutani H, Dohi K, Hartshorne DJ, Itoh T. New Isoform of Cardiac Myosin Light Chain Kinase and the Role of Cardiac Myosin Phosphorylation in α1-Adrenoceptor Mediated Inotropic Response. Plos One. 10: e0141130. PMID 26512720 DOI: 10.1371/Journal.Pone.0141130  0.43
2010 Mizutani H, Okamoto R, Moriki N, Konishi K, Taniguchi M, Fujita S, Dohi K, Onishi K, Suzuki N, Satoh S, Makino N, Itoh T, Hartshorne DJ, Ito M. Overexpression of myosin phosphatase reduces Ca(2+) sensitivity of contraction and impairs cardiac function. Circulation Journal : Official Journal of the Japanese Circulation Society. 74: 120-8. PMID 19966500 DOI: 10.1253/Circj.Cj-09-0462  0.396
2009 Funabara D, Osawa R, Ueda M, Kanoh S, Hartshorne DJ, Watabe S. Myosin loop 2 is involved in the formation of a trimeric complex of twitchin, actin, and myosin Journal of Biological Chemistry. 284: 18015-18020. PMID 19439402 DOI: 10.1074/Jbc.M109.016485  0.398
2008 Kusaka M, Ikeda D, Funabara D, Hartshorne DJ, Watabe S. The occurrence of tissue-specific twitchin isoforms in the mussel Mytilus galloprovincialis. Fisheries Science : Fs. 74: 677-686. PMID 19777122 DOI: 10.1111/J.1444-2906.2008.01574.X  0.365
2008 Yamashiro S, Yamakita Y, Totsukawa G, Goto H, Kaibuchi K, Ito M, Hartshorne DJ, Matsumura F. Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1. Developmental Cell. 14: 787-97. PMID 18477460 DOI: 10.1016/J.Devcel.2008.02.013  0.491
2008 Matsumura F, Hartshorne DJ. Myosin phosphatase target subunit: Many roles in cell function. Biochemical and Biophysical Research Communications. 369: 149-56. PMID 18155661 DOI: 10.1016/J.Bbrc.2007.12.090  0.507
2007 Funabara D, Hamamoto C, Yamamoto K, Inoue A, Ueda M, Osawa R, Kanoh S, Hartshorne DJ, Suzuki S, Watabe S. Unphosphorylated twitchin forms a complex with actin and myosin that may contribute to tension maintenance in catch Journal of Experimental Biology. 210: 4399-4410. PMID 18055628 DOI: 10.1242/Jeb.008722  0.421
2006 Lubomirov LT, Reimann K, Metzler D, Hasse V, Stehle R, Ito M, Hartshorne DJ, Gagov H, Pfitzer G, Schubert R. Urocortin-induced decrease in Ca2+ sensitivity of contraction in mouse tail arteries is attributable to cAMP-dependent dephosphorylation of MYPT1 and activation of myosin light chain phosphatase. Circulation Research. 98: 1159-67. PMID 16574904 DOI: 10.1161/01.Res.0000219904.43852.3E  0.487
2006 Okamoto R, Kato T, Mizoguchi A, Takahashi N, Nakakuki T, Mizutani H, Isaka N, Imanaka-Yoshida K, Kaibuchi K, Lu Z, Mabuchi K, Tao T, Hartshorne DJ, Nakano T, Ito M. Characterization and function of MYPT2, a target subunit of myosin phosphatase in heart. Cellular Signalling. 18: 1408-16. PMID 16431080 DOI: 10.1016/J.Cellsig.2005.11.001  0.483
2005 Funabara D, Kanoh S, Siegman MJ, Butler TM, Hartshorne DJ, Watabe S. Twitchin as a regulator of catch contraction in molluscan smooth muscle Journal of Muscle Research and Cell Motility. 26: 455-460. PMID 16453161 DOI: 10.1007/S10974-005-9029-2  0.527
2005 Murányi A, Derkach D, Erdodi F, Kiss A, Ito M, Hartshorne DJ. Phosphorylation of Thr695 and Thr850 on the myosin phosphatase target subunit: inhibitory effects and occurrence in A7r5 cells. Febs Letters. 579: 6611-5. PMID 16297917 DOI: 10.1016/J.Febslet.2005.10.055  0.486
2005 Lontay B, Kiss A, Gergely P, Hartshorne DJ, Erdodi F. Okadaic acid induces phosphorylation and translocation of myosin phosphatase target subunit 1 influencing myosin phosphorylation, stress fiber assembly and cell migration in HepG2 cells. Cellular Signalling. 17: 1265-75. PMID 16038801 DOI: 10.1016/J.Cellsig.2005.01.008  0.464
2005 Wu Y, Murányi A, Erdodi F, Hartshorne DJ. Localization of myosin phosphatase target subunit and its mutants. Journal of Muscle Research and Cell Motility. 26: 123-34. PMID 15999227 DOI: 10.1007/S10974-005-2579-5  0.317
2004 Lontay B, Serfozo Z, Gergely P, Ito M, Hartshorne DJ, Erdodi F. Localization of myosin phosphatase target subunit 1 in rat brain and in primary cultures of neuronal cells. The Journal of Comparative Neurology. 478: 72-87. PMID 15334650 DOI: 10.1002/Cne.20273  0.331
2004 Wooldridge AA, MacDonald JA, Erdodi F, Ma C, Borman MA, Hartshorne DJ, Haystead TA. Smooth muscle phosphatase is regulated in vivo by exclusion of phosphorylation of threonine 696 of MYPT1 by phosphorylation of Serine 695 in response to cyclic nucleotides. The Journal of Biological Chemistry. 279: 34496-504. PMID 15194681 DOI: 10.1074/Jbc.M405957200  0.549
2004 Hartshorne DJ, Ito M, Erdödi F. Role of protein phosphatase type 1 in contractile functions: myosin phosphatase. The Journal of Biological Chemistry. 279: 37211-4. PMID 15136561 DOI: 10.1074/Jbc.R400018200  0.366
2004 Ito M, Nakano T, Erdodi F, Hartshorne DJ. Myosin phosphatase: structure, regulation and function. Molecular and Cellular Biochemistry. 259: 197-209. PMID 15124925 DOI: 10.1023/B:Mcbi.0000021373.14288.00  0.566
2004 Totsukawa G, Wu Y, Sasaki Y, Hartshorne DJ, Yamakita Y, Yamashiro S, Matsumura F. Distinct roles of MLCK and ROCK in the regulation of membrane protrusions and focal adhesion dynamics during cell migration of fibroblasts. The Journal of Cell Biology. 164: 427-39. PMID 14757754 DOI: 10.1083/Jcb.200306172  0.429
2003 Wu Y, Erdodi F, Murányi A, Nullmeyer KD, Lynch RM, Hartshorne DJ. Myosin phosphatase and myosin phosphorylation in differentiating C2C12 cells. Journal of Muscle Research and Cell Motility. 24: 499-511. PMID 14870965 DOI: 10.1023/B:Jure.0000009810.36038.53  0.489
2003 Erdodi F, Kiss E, Walsh MP, Stefansson B, Deng JT, Eto M, Brautigan DL, Hartshorne DJ. Phosphorylation of protein phosphatase type-1 inhibitory proteins by integrin-linked kinase and cyclic nucleotide-dependent protein kinases. Biochemical and Biophysical Research Communications. 306: 382-7. PMID 12804574 DOI: 10.1016/S0006-291X(03)00976-8  0.47
2003 Funabara D, Watabe S, Mooers SU, Narayan S, Dudas C, Hartshorne DJ, Siegman MJ, Butler TM. Twitchin from molluscan catch muscle: primary structure and relationship between site-specific phosphorylation and mechanical function. The Journal of Biological Chemistry. 278: 29308-16. PMID 12756258 DOI: 10.1074/Jbc.M303272200  0.46
2003 Seko T, Ito M, Kureishi Y, Okamoto R, Moriki N, Onishi K, Isaka N, Hartshorne DJ, Nakano T. Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle. Circulation Research. 92: 411-8. PMID 12600888 DOI: 10.1161/01.Res.0000059987.90200.44  0.445
2002 Murányi A, MacDonald JA, Deng JT, Wilson DP, Haystead TA, Walsh MP, Erdodi F, Kiss E, Wu Y, Hartshorne DJ. Phosphorylation of the myosin phosphatase target subunit by integrin-linked kinase. The Biochemical Journal. 366: 211-6. PMID 12030846 DOI: 10.1042/Bj20020401  0.517
2002 Borman MA, MacDonald JA, Murányi A, Hartshorne DJ, Haystead TA. Smooth muscle myosin phosphatase-associated kinase induces Ca2+ sensitization via myosin phosphatase inhibition. The Journal of Biological Chemistry. 277: 23441-6. PMID 11976330 DOI: 10.1074/Jbc.M201597200  0.439
2002 Kiss E, Murányi A, Csortos C, Gergely P, Ito M, Hartshorne DJ, Erdodi F. Integrin-linked kinase phosphorylates the myosin phosphatase target subunit at the inhibitory site in platelet cytoskeleton. The Biochemical Journal. 365: 79-87. PMID 11931630 DOI: 10.1042/Bj20011295  0.513
2002 Shin HM, Je HD, Gallant C, Tao TC, Hartshorne DJ, Ito M, Morgan KG. Differential association and localization of myosin phosphatase subunits during agonist-induced signal transduction in smooth muscle. Circulation Research. 90: 546-53. PMID 11909818 DOI: 10.1161/01.Res.0000012822.23273.Ec  0.55
2001 Yamawaki K, Ito M, Machida H, Moriki N, Okamoto R, Isaka N, Shimpo H, Kohda A, Okumura K, Hartshorne DJ, Nakano T. Identification of human CPI-17, an inhibitory phosphoprotein for myosin phosphatase. Biochemical and Biophysical Research Communications. 285: 1040-5. PMID 11467857 DOI: 10.1006/Bbrc.2001.5290  0.302
2001 Funabara D, Kinoshita S, Watabe S, Siegman MJ, Butler TM, Hartshorne DJ. Phosphorylation of molluscan twitchin by the cAMP-dependent protein kinase Biochemistry. 40: 2087-2095. PMID 11329277 DOI: 10.1021/Bi0022691  0.431
2001 Araki S, Ito M, Kureishi Y, Feng J, Machida H, Isaka N, Amano M, Kaibuchi K, Hartshorne DJ, Nakano T. Arachidonic acid-induced Ca2+ sensitization of smooth muscle contraction through activation of Rho-kinase. Pflã¼Gers Archiv : European Journal of Physiology. 441: 596-603. PMID 11294240 DOI: 10.1007/S004240000462  0.545
2001 Murányi A, Zhang R, Liu F, Hirano K, Ito M, Epstein HF, Hartshorne DJ. Myotonic dystrophy protein kinase phosphorylates the myosin phosphatase targeting subunit and inhibits myosin phosphatase activity. Febs Letters. 493: 80-4. PMID 11287000 DOI: 10.1016/S0014-5793(01)02283-9  0.514
2001 MacDonald JA, Borman MA, Murányi A, Somlyo AV, Hartshorne DJ, Haystead TAJ. Identification of the endogenous smooth muscle myosin phosphatase-associated kinase Proceedings of the National Academy of Sciences of the United States of America. 98: 2419-2424. PMID 11226254 DOI: 10.1073/Pnas.041331498  0.536
2001 Butler TM, Narayan SR, Mooers SU, Hartshorne DJ, Siegman MJ. The myosin cross-bridge cycle and its control by twitchin phosphorylation in catch muscle Biophysical Journal. 80: 415-426. PMID 11159412 DOI: 10.1016/S0006-3495(01)76024-9  0.466
2000 Tóth A, Kiss E, Gergely P, Walsh MP, Hartshorne DJ, Erdödi F. Phosphorylation of MYPT1 by protein kinase C attenuates interaction with PP1 catalytic subunit and the 20 kDa light chain of myosin. Febs Letters. 484: 113-7. PMID 11068043 DOI: 10.1016/S0014-5793(00)02138-4  0.522
2000 Totsukawa G, Yamakita Y, Yamashiro S, Hartshorne DJ, Sasaki Y, Matsumura F. Distinct roles of ROCK (Rho-kinase) and MLCK in spatial regulation of MLC phosphorylation for assembly of stress fibers and focal adhesions in 3T3 fibroblasts Journal of Cell Biology. 150: 797-806. PMID 10953004 DOI: 10.1083/Jcb.150.4.797  0.48
2000 Hamaguchi T, Ito M, Feng J, Seko T, Koyama M, Machida H, Takase K, Amano M, Kaibuchi K, Hartshorne DJ, Nakano T. Phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by protein kinase N. Biochemical and Biophysical Research Communications. 274: 825-30. PMID 10924361 DOI: 10.1006/Bbrc.2000.3225  0.558
2000 Koyama M, Ito M, Feng J, Seko T, Shiraki K, Takase K, Hartshorne DJ, Nakano T. Phosphorylation of CPI-17, an inhibitory phosphoprotein of smooth muscle myosin phosphatase, by Rho-kinase. Febs Letters. 475: 197-200. PMID 10869555 DOI: 10.1016/S0014-5793(00)01654-9  0.52
2000 Tóth A, Kiss E, Herberg FW, Gergely P, Hartshorne DJ, Erdödi F. Study of the subunit interactions in myosin phosphatase by surface plasmon resonance. European Journal of Biochemistry. 267: 1687-97. PMID 10712600 DOI: 10.1046/J.1432-1327.2000.01158.X  0.372
2000 Swärd K, Dreja K, Susnjar M, Hellstrand P, Hartshorne DJ, Walsh MP. Inhibition of Rho-associated kinase blocks agonist-induced Ca2+ sensitization of myosin phosphorylation and force in guinea-pig ileum. The Journal of Physiology. 522: 33-49. PMID 10618150 DOI: 10.1111/J.1469-7793.2000.0033M.X  0.533
1999 Feng J, Ito M, Ichikawa K, Isaka N, Nishikawa M, Hartshorne DJ, Nakano T. Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase. The Journal of Biological Chemistry. 274: 37385-90. PMID 10601309 DOI: 10.1074/Jbc.274.52.37385  0.512
1999 Feng J, Ito M, Nishikawa M, Okinaka T, Isaka N, Hartshorne DJ, Nakano T. Dephosphorylation of distinct sites on the 20 kDa myosin light chain by smooth muscle myosin phosphatase. Febs Letters. 448: 101-4. PMID 10217418 DOI: 10.1016/S0014-5793(99)00337-3  0.542
1999 Hartshorne DJ, Hirano K. Interactions of protein phosphatase type 1, with a focus on myosin phosphatase. Molecular and Cellular Biochemistry. 190: 79-84. PMID 10098973 DOI: 10.1023/A:1006917032557  0.495
1999 Totsukawa G, Yamakita Y, Yamashiro S, Hosoya H, Hartshorne DJ, Matsumura F. Activation of myosin phosphatase targeting subunit by mitosis-specific phosphorylation Journal of Cell Biology. 144: 735-744. PMID 10037794 DOI: 10.1083/Jcb.144.4.735  0.499
1999 Feng J, Ito M, Kureishi Y, Ichikawa K, Amano M, Isaka N, Okawa K, Iwamatsu A, Kaibuchi K, Hartshorne DJ, Nakano T. Rho-associated kinase of chicken gizzard smooth muscle. The Journal of Biological Chemistry. 274: 3744-52. PMID 9920927 DOI: 10.1074/Jbc.274.6.3744  0.566
1999 Hirano M, Niiro N, Hirano K, Nishimura J, Hartshorne DJ, Kanaide H. Expression, subcellular localization, and cloning of the 130-kDa regulatory subunit of myosin phosphatase in porcine aortic endothelial cells. Biochemical and Biophysical Research Communications. 254: 490-6. PMID 9918866 DOI: 10.1006/Bbrc.1998.9973  0.361
1998 Hartshorne DJ. Myosin phosphatase: subunits and interactions. Acta Physiologica Scandinavica. 164: 483-93. PMID 9887971 DOI: 10.1046/j.1365-201X.1998.00447.x  0.426
1998 Tanaka J, Ito M, Feng J, Ichikawa K, Hamaguchi T, Nakamura M, Hartshorne DJ, Nakano T. Interaction of myosin phosphatase target subunit 1 with the catalytic subunit of type 1 protein phosphatase. Biochemistry. 37: 16697-703. PMID 9843438 DOI: 10.1021/Bi980782X  0.376
1998 Hartshorne DJ, Ito M, Erdödi F. Myosin light chain phosphatase: subunit composition, interactions and regulation. Journal of Muscle Research and Cell Motility. 19: 325-41. PMID 9635276 DOI: 10.1023/A:1005385302064  0.583
1998 Fujioka M, Takahashi N, Odai H, Araki S, Ichikawa K, Feng J, Nakamura M, Kaibuchi K, Hartshorne DJ, Nakano T, Ito M. A new isoform of human myosin phosphatase targeting/regulatory subunit (MYPT2): cDNA cloning, tissue expression, and chromosomal mapping. Genomics. 49: 59-68. PMID 9570949 DOI: 10.1006/Geno.1998.5222  0.38
1998 Siegman MJ, Funabara D, Kinoshita S, Watabe S, Hartshorne DJ, Butler TM. Phosphorylation of a twitchin-related protein controls catch and calcium sensitivity of force production in invertebrate smooth muscle Proceedings of the National Academy of Sciences of the United States of America. 95: 5383-5388. PMID 9560285 DOI: 10.1073/Pnas.95.9.5383  0.488
1998 Murányi A, Erdodi F, Ito M, Gergely P, Hartshorne DJ. Identification and localization of myosin phosphatase in human platelets. The Biochemical Journal. 330: 225-31. PMID 9461514 DOI: 10.1042/Bj3300225  0.44
1997 Siegman MJ, Mooers SU, Li C, Narayan S, Trinkle-Mulcahy L, Watabe S, Hartshorne DJ, Butler TM. Phosphorylation of a high molecular weight (-600 kDa) protein regulates catch in invertebrate smooth muscle Journal of Muscle Research and Cell Motility. 18: 655-670. PMID 9429159 DOI: 10.1023/A:1018683823020  0.506
1997 Murata K, Hirano K, Villa-Moruzzi E, Hartshorne DJ, Brautigan DL. Differential localization of myosin and myosin phosphatase subunits in smooth muscle cells and migrating fibroblasts Molecular Biology of the Cell. 8: 663-673. PMID 9247646 DOI: 10.1091/Mbc.8.4.663  0.33
1997 Nishio H, Ichikawa K, Hartshorne DJ. Evidence for myosin-binding phosphatase in heart myofibrils. Biochemical and Biophysical Research Communications. 236: 570-5. PMID 9245690 DOI: 10.1006/Bbrc.1997.7005  0.401
1997 Ito M, Feng J, Tsujino S, Inagaki N, Inagaki M, Tanaka J, Ichikawa K, Hartshorne DJ, Nakano T. Interaction of smooth muscle myosin phosphatase with phospholipids. Biochemistry. 36: 7607-14. PMID 9200713 DOI: 10.1021/Bi9702647  0.512
1997 Hirano K, Hirano M, Hartshorne DJ. Cloning and characterization of a protein phosphatase type 1-binding subunit from smooth muscle similar to the glycogen-binding subunit of liver. Biochimica Et Biophysica Acta. 1339: 177-80. PMID 9187237 DOI: 10.1016/S0167-4838(97)00048-4  0.373
1997 Hirano K, Phan BC, Hartshorne DJ. Interactions of the subunits of smooth muscle myosin phosphatase. The Journal of Biological Chemistry. 272: 3683-8. PMID 9013623 DOI: 10.1074/Jbc.272.6.3683  0.397
1997 Nishiyama U, Ubukata M, Magae J, Kataoka T, Erdödi F, Hartshorne DJ, Isono K, Nagai K, Osada H. Structure-activity relationship within a series of degradation products of tautomycin. Bioscience, Biotechnology, and Biochemistry. 60: 103-7. PMID 8824829 DOI: 10.1271/BBB.60.103  0.325
1997 Tsuchiya T, Ikeda N, Obara K, Hartshorne DJ. A Type 2A Protein Phosphatase from Clam Smooth Muscle. Use of 4-Methylumbelliferyl Phosphate as Substrate Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. 118: 17-21. DOI: 10.1016/S0305-0491(97)00005-9  0.387
1996 Holden HM, Wesenberg G, Raynes DA, Hartshorne DJ, Guerriero V, Rayment I. Molecular structure of a proteolytic fragment of TLP20. Acta Crystallographica. Section D, Biological Crystallography. 52: 1153-60. PMID 15299576 DOI: 10.1107/S0907444996008128  0.383
1996 Hirano K, Erdödi F, Patton JG, Hartshorne DJ. Interaction of protein phosphatase type 1 with a splicing factor. Febs Letters. 389: 191-4. PMID 8766827 DOI: 10.1016/0014-5793(96)00577-7  0.383
1996 Ichikawa K, Hirano K, Ito M, Tanaka J, Nakano T, Hartshorne DJ. Interactions and properties of smooth muscle myosin phosphatase. Biochemistry. 35: 6313-20. PMID 8639575 DOI: 10.1021/Bi960208Q  0.485
1996 Ichikawa K, Ito M, Hartshorne DJ. Phosphorylation of the large subunit of myosin phosphatase and inhibition of phosphatase activity. The Journal of Biological Chemistry. 271: 4733-40. PMID 8617739 DOI: 10.1074/Jbc.271.9.4733  0.511
1995 Kurisaki T, Taylor RG, Hartshorne DJ. Effects of the protein phosphatase inhibitors, tautomycin and calyculin-A, on protein phosphorylation and cytoskeleton of human platelets. Cell Structure and Function. 20: 331-43. PMID 8581989 DOI: 10.1247/Csf.20.331  0.475
1995 Hirano K, Ito M, Hartshorne DJ. Interaction of the ribosomal protein, L5, with protein phosphatase type 1. The Journal of Biological Chemistry. 270: 19786-90. PMID 7649987 DOI: 10.1074/Jbc.270.34.19786  0.378
1995 Trinkle-Mulcahy L, Ichikawa K, Hartshorne DJ, Siegman MJ, Butler TM. Thiophosphorylation of the 130-kDa subunit is associated with a decreased activity of myosin light chain phosphatase in α-toxin-permeabilized smooth muscle Journal of Biological Chemistry. 270: 18191-18194. PMID 7629133 DOI: 10.1074/Jbc.270.31.18191  0.485
1994 Okubo S, Ito M, Takashiba Y, Ichikawa K, Miyahara M, Shimizu H, Konishi T, Shima H, Nagao M, Hartshorne DJ. A regulatory subunit of smooth muscle myosin bound phosphatase. Biochemical and Biophysical Research Communications. 200: 429-34. PMID 8166716 DOI: 10.1006/Bbrc.1994.1467  0.431
1994 Matsushima S, Huang YP, Dudas CV, Guerriero V, Hartshorne DJ. Mutants of smooth muscle myosin light chain kinase at tryptophan 800. Biochemical and Biophysical Research Communications. 202: 1329-36. PMID 8060310 DOI: 10.1006/Bbrc.1994.2076  0.435
1994 Raynes DA, Hartshorne DJ, Guerriero V. Sequence and expression of a baculovirus protein with antigenic similarity to telokin. The Journal of General Virology. 75: 1807-9. PMID 7517434 DOI: 10.1099/0022-1317-75-7-1807  0.328
1993 Kanoh S, Ito M, Niwa E, Kawano Y, Hartshorne DJ. Actin-binding peptide from smooth muscle myosin light chain kinase. Biochemistry. 32: 8902-7. PMID 8364036 DOI: 10.1021/Bi00085A023  0.46
1993 Hirano K, Hartshorne DJ. Phosphorylation of vimentin in the C-terminal domain after exposure to calyculin-A. European Journal of Cell Biology. 62: 59-65. PMID 8269979  0.359
1993 Ikebe M, Mitra S, Hartshorne DJ. Cleavage at site A, Glu-642 to Ser-643, of the gizzard myosin heavy chain decreases affinity for actin. The Journal of Biological Chemistry. 268: 25948-51. PMID 7902357  0.351
1992 Holden HM, Ito M, Hartshorne DJ, Rayment I. X-ray structure determination of telokin, the C-terminal domain of myosin light chain kinase, at 2.8 A resolution. Journal of Molecular Biology. 227: 840-51. PMID 1404391 DOI: 10.1016/0022-2836(92)90226-A  0.34
1992 Miki M, Walsh MP, Hartshorne DJ. The mechanism of inhibition of the actin-activated myosin MgATPase by calponin. Biochemical and Biophysical Research Communications. 187: 867-71. PMID 1388358 DOI: 10.1016/0006-291X(92)91277-W  0.435
1992 Hirano K, Chartier L, Taylor RG, Allen RE, Fusetani N, Karaki H, Hartshorne DJ. Changes in the cytoskeleton of 3T3 fibroblasts induced by the phosphatase inhibitor, calyculin-A Journal of Muscle Research and Cell Motility. 13: 341-353. PMID 1326568 DOI: 10.1007/Bf01766462  0.33
1992 Okubo S, Ito M, Ichikawa K, Konishi T, Nakano T, Kawamura T, Hartshorne DJ. Smooth muscle myosin light chain phosphatase. Japanese Journal of Pharmacology. 58: 267P. PMID 1324340 DOI: 10.1016/0022-2828(92)90587-P  0.414
1991 Ito M, Guerriero V, Chen XM, Hartshorne DJ. Definition of the inhibitory domain of smooth muscle myosin light chain kinase by site-directed mutagenesis. Biochemistry. 30: 3498-503. PMID 2012809 DOI: 10.1021/Bi00228A021  0.596
1991 Anderson TA, Ito M, Hartshorne DJ, Rayment I. Crystallization and preliminary analysis of telokin, the C-terminal domain of myosin light chain kinase Journal of Molecular Biology. 217: 621-623. PMID 2005615 DOI: 10.1016/0022-2836(91)90519-C  0.382
1991 Pearson RB, Ito M, Morrice NA, Smith AJ, Condron R, Wettenhall RE, Kemp BE, Hartshorne DJ. Proteolytic cleavage sites in smooth muscle myosin-light-chain kinase and their relation to structural and regulatory domains. European Journal of Biochemistry. 200: 723-30. PMID 1915344 DOI: 10.1111/J.1432-1033.1991.Tb16237.X  0.451
1991 Chartier L, Rankin LL, Allen RE, Kato Y, Fusetani N, Karaki H, Watabe S, Hartshorne DJ. Calyculin-A increases the level of protein phosphorylation and changes the shape of 3T3 fibroblasts. Cell Motility and the Cytoskeleton. 18: 26-40. PMID 1848484 DOI: 10.1002/Cm.970180104  0.42
1991 Ikebe M, Hewett TE, Martin AF, Chen M, Hartshorne DJ. Cleavage of a smooth muscle myosin heavy chain near its C terminus by alpha-chymotrypsin. Effect on the properties of myosin. The Journal of Biological Chemistry. 266: 7030-6. PMID 1826682  0.377
1991 Ito M, Guerriero V, Hartshorne DJ. Structure-function relationships in smooth muscle myosin light chain kinase. Advances in Experimental Medicine and Biology. 304: 3-10. PMID 1803904 DOI: 10.1007/978-1-4684-6003-2_2  0.543
1991 Hori M, Magae J, Han YG, Hartshorne DJ, Karaki H. A novel protein phosphatase inhibitor, tautomycin. Effect on smooth muscle. Febs Letters. 285: 145-8. PMID 1648511 DOI: 10.1016/0014-5793(91)80745-O  0.504
1990 Sommerville LE, Henry GD, Sykes BD, Hartshorne DJ. Spin-echo 1H NMR studies of differential mobility in gizzard myosin and its subfragments. Biochemistry. 29: 10855-64. PMID 2271685 DOI: 10.1021/Bi00500A020  0.347
1990 Watabe S, Hartshorne DJ. Paramyosin and the catch mechanism. Comparative Biochemistry and Physiology. B, Comparative Biochemistry. 96: 639-46. PMID 2225769 DOI: 10.1016/0305-0491(90)90207-A  0.464
1990 Ito M, Hartshorne DJ. Phosphorylation of myosin as a regulatory mechanism in smooth muscle. Progress in Clinical and Biological Research. 327: 57-72. PMID 2181476  0.486
1990 Eriksson JE, Toivola D, Meriluoto JA, Karaki H, Han YG, Hartshorne D. Hepatocyte deformation induced by cyanobacterial toxins reflects inhibition of protein phosphatases. Biochemical and Biophysical Research Communications. 173: 1347-53. PMID 2176489 DOI: 10.1016/S0006-291X(05)80936-2  0.399
1989 Rüegg JC, Zeugner C, Strauss JD, Paul RJ, Kemp B, Chem M, Li AY, Hartshorne DJ. A calmodulin-binding peptide relaxes skinned muscle from guinea-pig taenia coli. PflüGers Archiv : European Journal of Physiology. 414: 282-5. PMID 2780212 DOI: 10.1007/Bf00584627  0.436
1989 Ito M, Dabrowska R, Guerriero V, Hartshorne DJ. Identification in turkey gizzard of an acidic protein related to the C-terminal portion of smooth muscle myosin light chain kinase. The Journal of Biological Chemistry. 264: 13971-4. PMID 2760053  0.432
1989 Hartshorne DJ, Ito M, Ikebe M. Myosin and contractile activity in smooth muscle. Advances in Experimental Medicine and Biology. 255: 269-77. PMID 2694808 DOI: 10.1007/978-1-4684-5679-0_30  0.544
1989 Abougou JC, Hagiwara M, Hachiya T, Terasawa M, Hidaka H, Hartshorne DJ. Phosphorylation of caldesmon. Febs Letters. 257: 408-10. PMID 2555223 DOI: 10.1016/0014-5793(89)81583-2  0.498
1989 Merkel L, Ikebe M, Hartshorne DJ. Interaction of smooth muscle tropomyosin and smooth muscle myosin. Effect on the properties of myosin. Biochemistry. 28: 2215-20. PMID 2541778 DOI: 10.1021/Bi00431A037  0.467
1989 Higashihara M, Hartshorne DJ, Craig R, Ikebe M. Correlation of enzymatic properties and conformation of bovine erythrocyte myosin. Biochemistry. 28: 1642-9. PMID 2541759 DOI: 10.1021/Bi00430A032  0.476
1989 Watabe S, Tsuchiya T, Hartshorne DJ. Phosphorylation of paramyosin. Comparative Biochemistry and Physiology. B, Comparative Biochemistry. 94: 813-21. PMID 2532591 DOI: 10.1016/0305-0491(89)90171-5  0.503
1989 Ito M, Pierce PR, Allen RE, Hartshorne DJ. Effect of monoclonal antibodies on the properties of smooth muscle myosin. Biochemistry. 28: 5567-72. PMID 2528373 DOI: 10.1021/Bi00439A034  0.376
1989 Itoh T, Ikebe M, Kargacin GJ, Hartshorne DJ, Kemp BE, Fay FS. Effects of modulators of myosin light-chain kinase activity in single smooth muscle cells. Nature. 338: 164-7. PMID 2493140 DOI: 10.1038/338164a0  0.367
1989 Hartshorne DJ. Tribute to Emil Bozler: frontiers in smooth muscle research, Emil Bozler international symposium Journal of Muscle Research and Cell Motility. 10: 399-402. DOI: 10.1007/Bf01771815  0.315
1988 Pearson RB, Wettenhall RE, Means AR, Hartshorne DJ, Kemp BE. Autoregulation of enzymes by pseudosubstrate prototopes: myosin light chain kinase. Science (New York, N.Y.). 241: 970-3. PMID 3406746 DOI: 10.1126/Science.3406746  0.447
1988 Ikebe M, Koretz J, Hartshorne DJ. Effects of phosphorylation of light chain residues threonine 18 and serine 19 on the properties and conformation of smooth muscle myosin Journal of Biological Chemistry. 263: 6432-6437. PMID 2966156  0.45
1987 Ikebe M, Stepinska M, Kemp BE, Means AR, Hartshorne DJ. Proteolysis of smooth muscle myosin light chain kinase. Formation of inactive and calmodulin-independent fragments. The Journal of Biological Chemistry. 262: 13828-34. PMID 3654638  0.468
1987 Barsotti RJ, Ikebe M, Hartshorne DJ. Effects of Ca2+, Mg2+, and myosin phosphorylation on skinned smooth muscle fibers. The American Journal of Physiology. 252: C543-54. PMID 3578506 DOI: 10.1152/ajpcell.1987.252.5.C543  0.31
1987 Ikebe M, Hartshorne DJ, Elzinga M. Phosphorylation of the 20,000-dalton light chain of smooth muscle myosin by the calcium-activated, phospholipid-dependent protein kinase. Phosphorylation sites and effects of phosphorylation Journal of Biological Chemistry. 262: 9569-9573. PMID 3036866  0.465
1986 Ikebe M, Hartshorne DJ. Proteolysis and actin-binding properties of 10S and 6S smooth muscle myosin: identification of a site protected from proteolysis in the 10S conformation and by the binding of actin. Biochemistry. 25: 6177-85. PMID 3790513  0.33
1986 Sommerville LE, Hartshorne DJ. Intracellular calcium and smooth muscle contraction. Cell Calcium. 7: 353-64. PMID 3545487 DOI: 10.1016/0143-4160(86)90038-2  0.401
1986 Ikebe M, Hartshorne DJ. Reverse reaction of smooth muscle myosin light chain kinase. Formation of ATP from phosphorylated light chain plus ADP. The Journal of Biological Chemistry. 261: 8249-53. PMID 3522566  0.372
1986 Ikebe M, Hartshorne DJ, Elzinga M. Identification, phosphorylation, and dephosphorylation of a second site for myosin light chain kinase on the 20,000-dalton light chain of smooth muscle myosin Journal of Biological Chemistry. 261: 36-39. PMID 3079756  0.399
1985 Ikebe M, Hartshorne DJ. The role of myosin phosphorylation in the contraction-relaxation cycle of smooth muscle. Experientia. 41: 1006-10. PMID 3160603 DOI: 10.1007/BF01952122  0.439
1985 Mrwa U, Güth K, Rüegg JC, Paul RJ, Boström S, Barsotti R, Hartshorne D. Mechanical and biochemical characterization of the contraction elicited by a calcium-independent myosin light chain kinase in chemically skinned smooth muscle. Experientia. 41: 1002-6. PMID 3160602 DOI: 10.1007/Bf01952121  0.344
1985 Ikebe M, Hartshorne DJ. Proteolysis of smooth muscle myosin by Staphylococcus aureus protease: preparation of heavy meromyosin and subfragment 1 with intact 20 000-dalton light chains. Biochemistry. 24: 2380-7. PMID 3158349 DOI: 10.1021/Bi00330A038  0.499
1985 Srivastava S, Ikebe M, Hartshorne DJ. Trinitrophenylation of smooth muscle myosin. Biochemical and Biophysical Research Communications. 126: 748-55. PMID 3156591 DOI: 10.1016/0006-291X(85)90248-7  0.52
1985 Ikebe M, Hartshorne DJ. Effects of Ca2+ on the conformation and enzymatic activity of smooth muscle myosin. The Journal of Biological Chemistry. 260: 13146-53. PMID 2932435  0.344
1984 Gagelmann M, Mrwa U, Bostrom S, Rüegg JC, Hartshorne D. Effect of Ca2+-independent myosin light chain kinase on different skinned smooth muscle fibers. Pflugers Archiv : European Journal of Physiology. 401: 107-9. PMID 6548012 DOI: 10.1007/Bf00581542  0.452
1984 Walsh MP, Hinkins S, Dabrowska R, Hartshorne DJ. Smooth muscle myosin light chain kinase. Methods in Enzymology. 99: 279-88. PMID 6358787 DOI: 10.1016/0076-6879(83)99063-8  0.502
1984 Ikebe M, Barsotti RJ, Hinkins S, Hartshorne DJ. Effects of magnesium chloride on smooth muscle actomyosin adenosine-5'-triphosphatase activity, myosin conformation, and tension development in glycerinated smooth muscle fibers. Biochemistry. 23: 5062-8. PMID 6238628 DOI: 10.1021/Bi00316A036  0.435
1983 Walsh MP, Hinkins S, Flink IL, Hartshorne DJ. Bovine stomach myosin light chain kinase: purification, characterization, and comparison with the turkey gizzard enzyme. Biochemistry. 21: 6890-6. PMID 6897613 DOI: 10.1021/Bi00269A041  0.436
1983 Walsh MP, Bridenbaugh R, Kerrick WG, Hartshorne DJ. Gizzard Ca2+-independent myosin light chain kinase: evidence in favor of the phosphorylation theory. Federation Proceedings. 42: 45-50. PMID 6848377  0.441
1983 Srivastava S, Hartshorne DJ. Conversion of a Ca2+-dependent myosin light chain kinase from skeletal muscle to a Ca2+-independent form. Biochemical and Biophysical Research Communications. 110: 701-8. PMID 6687681 DOI: 10.1016/0006-291X(83)91206-8  0.49
1983 Walsh MP, Hinkins S, Muguruma M, Hartshorne DJ. Identification of two forms of myosin light chain kinase in turkey gizzard. Febs Letters. 153: 156-60. PMID 6687459 DOI: 10.1016/0014-5793(83)80138-0  0.457
1983 Persechini A, Hartshorne DJ. Ordered phosphorylation of the two 20 000 molecular weight light chains of smooth muscle myosin. Biochemistry. 22: 470-6. PMID 6687432 DOI: 10.1021/bi00271a033  0.403
1983 Ikebe M, Hinkins S, Hartshorne DJ. Correlation of enzymatic properties and conformation of smooth muscle myosin. Biochemistry. 22: 4580-7. PMID 6138093 DOI: 10.1021/Bi00288A036  0.451
1983 HARTSHORNE DJ. CALMODULIN IN SKELETAL MUSCLE Journal of Food Biochemistry. 7: 211-221. DOI: 10.1111/J.1745-4514.1983.Tb00799.X  0.477
1982 Dabrowska R, Hinkins S, Walsh MP, Hartshorne DJ. The binding of smooth muscle myosin light chain kinase to actin. Biochemical and Biophysical Research Communications. 107: 1524-31. PMID 6982712 DOI: 10.1016/S0006-291X(82)80172-1  0.518
1982 Walsh MP, Dabrowska R, Hinkins S, Hartshorne DJ. Calcium-independent myosin light chain kinase of smooth muscle. Preparation by limited chymotryptic digestion of the calcium ion dependent enzyme, purification, and characterization. Biochemistry. 21: 1919-25. PMID 6896283 DOI: 10.1021/Bi00537A034  0.481
1981 Walsh MP, Persechini A, Hinkins S, Hartshorne DJ. Is smooth muscle myosin a substrate for the cAMP-dependent protein kinase? Febs Letters. 126: 107-10. PMID 6894576 DOI: 10.1016/0014-5793(81)81044-7  0.563
1981 Persechini A, Hartshorne DJ. Phosphorylation of smooth muscle myosin: evidence for cooperativity between the myosin heads. Science (New York, N.Y.). 213: 1383-5. PMID 6455737 DOI: 10.1126/science.6455737  0.405
1981 Persechini A, Mrwa U, Hartshorne DJ. Effect of phosphorylation on the actin-activated ATPase activity of myosin. Biochemical and Biophysical Research Communications. 98: 800-5. PMID 6452877 DOI: 10.1016/0006-291X(81)91182-7  0.505
1981 Walsh MP, Hinkins S, Hartshorne DJ. Phosphorylation of smooth muscle actin by the catalytic subunit of the cAMP-dependent protein kinase. Biochemical and Biophysical Research Communications. 102: 149-57. PMID 6272789 DOI: 10.1016/0006-291X(81)91501-1  0.531
1980 Hartshorne DJ. Biochemical basis for contraction of vascular smooth muscle. Chest. 78: 140-9. PMID 6447058 DOI: 10.1378/Chest.78.1_Supplement.140  0.461
1979 Dabrowska R, Hartshorne DJ. A Ca2+-and modulator-dependent myosin light chain kinase from non-muscle cells. Biochemical and Biophysical Research Communications. 85: 1352-9. PMID 743302 DOI: 10.1016/0006-291X(78)91152-X  0.549
1979 Yerna MJ, Hartshorne DJ, Goldman RD. Isolation and characterization of baby hamster kidney (BHK-21) cell modulator protein. Biochemistry. 18: 673-8. PMID 217421 DOI: 10.1021/Bi00571A019  0.423
1979 Yerna MJ, Dabrowska R, Hartshorne DJ, Goldman RD. Calcium-sensitive regulation of actin-myosin interactions in baby hamster kidney (BHK-21) cells. Proceedings of the National Academy of Sciences of the United States of America. 76: 184-8. PMID 154671 DOI: 10.1073/Pnas.76.1.184  0.474
1978 Dabrowska R, Sherry JM, Aromatorio DK, Hartshorne DJ. Modulator protein as a component of the myosin light chain kinase from chicken gizzard. Biochemistry. 17: 253-8. PMID 202300 DOI: 10.1021/Bi00595A010  0.516
1978 Sherry JM, Górecka A, Aksoy MO, Dabrowska R, Hartshorne DJ. Roles of calcium and phosphorylation in the regulation of the activity of gizzard myosin. Biochemistry. 17: 4411-8. PMID 152641 DOI: 10.1021/Bi00614A009  0.408
1977 Dabrowska R, Aromatorio D, Sherry JM, Hartshorne DJ. Composition of the myosin light chain kinase from chicken gizzard. Biochemical and Biophysical Research Communications. 78: 1263-72. PMID 144501 DOI: 10.1016/0006-291X(77)91429-2  0.315
1976 Górecka A, Aksoy MO, Hartshorne DJ. The effect of phosphorylation of gizzard myosin on actin activation. Biochemical and Biophysical Research Communications. 71: 325-31. PMID 962924 DOI: 10.1016/0006-291X(76)90286-2  0.395
1967 Schaub MC, Perry SV, Hartshorne DJ. The effect of tropomyosin on the adenosine triphosphatase activity of desensitized actomyosin. The Biochemical Journal. 105: 1235-43. PMID 16742551  0.553
1967 Schaub MC, Hartshorne DJ, Perry SV. Effect of tropomyosin on the calcium-activated adenosine triphosphatase of actomyosin [28] Nature. 215: 635-636. PMID 4227837 DOI: 10.1038/215635a0  0.463
1967 Hartshorne DJ, Perry SV, Schaub MC. A protein factor inhibiting the magnesium-activated adenosine triphosphatase of desensitized actomyosin Biochemical Journal. 104: 907-913. PMID 4227823  0.548
1967 Schaub MC, Hartshorne DJ, Perry SV. The adeonosine-triphosphatase activity of desensitized actomyosin Biochemical Journal. 104: 263-269. PMID 4226811  0.54
1966 Hartshorne DJ, Perry SV, Davies V. A factor inhibiting the adenosine triphosphatase activity and the superprecipitation of actomyosin [21] Nature. 209: 1352-1353. PMID 4224839 DOI: 10.1038/2091352a0  0.485
1965 Hartshorne D, Morales M. Enzymatic modification of myosin by disulfide exchange Biochemistry. 4: 18-22. PMID 14285236 DOI: 10.1021/Bi00877A004  0.32
1962 HARTSHORNE DJ, PERRY SV. A chromatographic and electrophoretic study of sarcoplasm from adult--and foetal-rabbit muscles The Biochemical Journal. 85: 171-177. PMID 13953171  0.487
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