Leonard G Luyt - Publications

The University of Western Ontario (Canada) 
organic chemistry, medicinal chemistry, radiochemistry

49 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Hauser-Kawaguchi A, Tolg C, Peart T, Milne M, Turley EA, Luyt LG. Corrigendum to "A truncated RHAMM protein for discovering novel therapeutic peptides" [Bioorg. Med. Chem. 26 (2018) 5194-5203]. Bioorganic & Medicinal Chemistry. 115543. PMID 32423782 DOI: 10.1016/j.bmc.2020.115543  0.48
2020 Murrell E, Luyt LG. Incorporation of Fluorine into an OBOC Peptide Library by Copper-Free Click Chemistry toward the Discovery of PET Imaging Agents. Acs Combinatorial Science. PMID 32011850 DOI: 10.1021/acscombsci.9b00146  1
2019 Ghiassian S, Yu L, Gobbo P, Nazemi A, Romagnoli T, Luo W, Luyt LG, Workentin MS. Nitrone-Modified Gold Nanoparticles: Synthesis, Characterization, and Their Potential as F-Labeled Positron Emission Tomography Probes via I-SPANC. Acs Omega. 4: 19106-19115. PMID 31763533 DOI: 10.1021/acsomega.9b02322  0.44
2019 Turnbull WL, Murrell E, Bulcan-Gnirss M, Majeed M, Milne M, Luyt LG. A study of Tc/Re-tricarbonyl complexes of 4-amino-1,8-naphthalimides. Dalton Transactions (Cambridge, England : 2003). PMID 31490511 DOI: 10.1039/c9dt01752f  1
2019 Lalonde T, Hou J, Thibeault PE, Milne M, Dhanvantari S, Ramachandran R, Luyt LG. Single Amino Acid Replacement in G-7039 Leads to a 70-Fold Increase in Binding Towards GHS-R1a. Chemmedchem. PMID 31469937 DOI: 10.1002/cmdc.201900466  0.56
2019 LeSarge JC, Thibeault P, Milne M, Ramachandran R, Luyt LG. High Affinity Fluorescent Probe for Proteinase-Activated Receptor 2 (PAR2). Acs Medicinal Chemistry Letters. 10: 1045-1050. PMID 31312406 DOI: 10.1021/acsmedchemlett.9b00094  0.48
2019 Sullivan R, Randhawa VK, Stokes A, Wu D, Lalonde T, Kiaii B, Luyt L, Wisenberg G, Dhanvantari S. Dynamics of the Ghrelin/Growth Hormone Secretagogue Receptor System in the Human Heart Before and After Cardiac Transplantation. Journal of the Endocrine Society. 3: 748-762. PMID 30937420 DOI: 10.1210/js.2018-00393  0.44
2019 Yu L, Despotovic N, Kovacs MS, Pin CL, Luyt LG. F-Labeled PET Probe Targeting Enhancer of Zeste Homologue 2 (EZH2) for Cancer Imaging. Acs Medicinal Chemistry Letters. 10: 334-340. PMID 30891136 DOI: 10.1021/acsmedchemlett.8b00613  0.52
2018 Turnbull WL, Yu L, Murrell E, Milne M, Charron CL, Luyt LG. A dual modality Tc/Re(i)-labelled T140 analogue for imaging of CXCR4 expression. Organic & Biomolecular Chemistry. PMID 30574973 DOI: 10.1039/c8ob01947a  1
2018 Charron CL, McFarland MS, Dhanvantari S, Luyt LG. Development of a [Ga]-ghrelin analogue for PET imaging of the ghrelin receptor (GHS-R1a). Medchemcomm. 9: 1761-1767. PMID 30429981 DOI: 10.1039/c8md00210j  0.52
2018 Hauser-Kawaguchi A, Milne M, Li F, Lee TY, Luyt LG. The development of a near infrared inulin optical probe for measuring glomerular filtration rate. International Journal of Biological Macromolecules. PMID 30419331 DOI: 10.1016/j.ijbiomac.2018.11.034  0.48
2018 Abbas A, Yu L, Lalonde T, Wu D, Thiessen JD, Luyt LG, Dhanvantari S. Development and Characterization of an F-labeled Ghrelin Peptidomimetic for Imaging the Cardiac Growth Hormone Secretagogue Receptor. Molecular Imaging. 17: 1536012118809587. PMID 30394854 DOI: 10.1177/1536012118809587  0.44
2018 Fowkes MM, Lalonde T, Yu L, Dhanvantari S, Kovacs MS, Luyt LG. Peptidomimetic growth hormone secretagogue derivatives for positron emission tomography imaging of the ghrelin receptor. European Journal of Medicinal Chemistry. 157: 1500-1511. PMID 30282322 DOI: 10.1016/j.ejmech.2018.08.062  0.52
2018 Hauser-Kawaguchi A, Tolg C, Peart T, Milne M, Turley EA, Luyt LG. A truncated RHAMM protein for discovering novel therapeutic peptides. Bioorganic & Medicinal Chemistry. PMID 30249497 DOI: 10.1016/j.bmc.2018.09.018  0.48
2018 Turnbull WL, Luyt LG. Amino-Substituted 2,2'-Bipyridine Ligands as Fluorescent Indicators for Zn(II) and Applications for Fluorescence Imaging of Prostate Cells. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 30051526 DOI: 10.1002/chem.201803051  0.48
2018 Murrell E, Kovacs MS, Luyt LG. A Compact and Synthetically Accessible Fluorine-18 Labelled Cyclooctyne Prosthetic Group for Labelling of Biomolecules by Copper-free Click Chemistry. Chemmedchem. PMID 29923326 DOI: 10.1002/cmdc.201800334  1
2018 Sullivan R, McGirr R, Hu S, Tan A, Wu D, Charron C, Lalonde T, Arany E, Chakrabarti S, Luyt L, Dhanvantari S. Changes in the Cardiac GHSR1a-Ghrelin System Correlate With Myocardial Dysfunction in Diabetic Cardiomyopathy in Mice. Journal of the Endocrine Society. 2: 178-189. PMID 29450407 DOI: 10.1210/js.2017-00433  0.44
2018 Hou JQ, Kovacs MS, Dhanvantari S, Luyt LG. Development of Candidates for PET Imaging of Ghrelin Receptor in Disease: Design, Synthesis and Evaluation of Fluorine-bearing Quinazolinone Derivatives. Journal of Medicinal Chemistry. PMID 29327929 DOI: 10.1021/acs.jmedchem.7b01754  0.52
2017 Cho CF, Yu L, Nsiama TK, Kadam AN, Raturi A, Shukla S, Amadei GA, Steinmetz NF, Luyt LG, Lewis JD. Viral nanoparticles decorated with novel EGFL7 ligands enable intravital imaging of tumor neovasculature. Nanoscale. PMID 28799610 DOI: 10.1039/c7nr02558k  0.44
2017 Charron CL, Hou JQ, McFarland MS, Dhanvantari S, Kovacs MS, Luyt LG. Structure-Activity Study of Ghrelin(1-8) Resulting in High Affinity Fluorine-bearing Ligands for the Ghrelin Receptor. Journal of Medicinal Chemistry. PMID 28719746 DOI: 10.1021/acs.jmedchem.7b00164  0.52
2017 Simpson EJ, Gobbo P, Bononi FC, Murrell E, Workentin MS, Luyt LG. Bombesin-functionalized water-soluble gold nanoparticles for targeting prostate cancer Journal of Interdisciplinary Nanomedicine. 2: 174-187. DOI: 10.1002/jin2.33  1
2016 Hou J, Charron CL, Fowkes MM, Luyt LG. Bridging computational modeling with amino acid replacements to investigate GHS-R1a-peptidomimetic recognition. European Journal of Medicinal Chemistry. 123: 822-833. PMID 27541265 DOI: 10.1016/j.ejmech.2016.07.078  0.8
2016 Cho CF, Lee K, Speranza MC, Bononi FC, Viapiano MS, Luyt LG, Weissleder R, Chiocca EA, Lee H, Lawler SE. Design of a microfluidic chip for magnetic-activated sorting of one-bead-one-compound libraries. Acs Combinatorial Science. PMID 27124678 DOI: 10.1021/acscombsci.5b00180  0.8
2016 Gavin CT, Ali SN, Tailly T, Olvera-Posada D, Alenezi H, Power NE, Hou J, St Amant AH, Luyt LG, Wood S, Wu C, Razvi H, Leong HS. Novel Methods of Determining Urinary Calculi Composition: Petrographic Thin Sectioning of Calculi and Nanoscale Flow Cytometry Urinalysis. Scientific Reports. 6: 19328. PMID 26771074 DOI: 10.1038/srep19328  0.8
2016 Lu YJ, Deng Q, Hou JQ, Hu DP, Wang ZY, Zhang K, Luyt LG, Wong WL, Chow CF. Molecular Engineering of Thiazole Orange Dye: Change of Fluorescent Signaling from Universal to Specific upon Binding with Nucleic Acids in Bioassay. Acs Chemical Biology. PMID 26752011 DOI: 10.1021/acschembio.5b00987  0.8
2015 Esguerra KV, Tolg C, Akentieva N, Price M, Cho CF, Lewis JD, McCarthy JB, Turley EA, Luyt LG. Identification, design and synthesis of tubulin-derived peptides as novel hyaluronan mimetic ligands for the receptor for hyaluronan-mediated motility (RHAMM/HMMR). Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 26456171 DOI: 10.1039/c5ib00222b  0.8
2015 Maar RR, Barbon SM, Sharma N, Groom H, Luyt LG, Gilroy JB. Evaluation of Anisole-Substituted Boron Difluoride Formazanate Complexes for Fluorescence Cell Imaging. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 26397738 DOI: 10.1002/chem.201502821  0.8
2015 Behnam Azad B, Rota V, Yu L, McGirr R, St Amant AH, Lee TY, Dhanvantari S, Luyt LG. Synthesis and evaluation of optical and PET GLP-1 peptide analogues for GLP-1R imaging. Molecular Imaging. 14. PMID 25762192  0.44
2015 Bononi FC, Luyt LG. Synthesis and cell-based screening of one-bead-one-compound peptide libraries. Methods in Molecular Biology (Clifton, N.J.). 1248: 223-37. PMID 25616336 DOI: 10.1007/978-1-4939-2020-4_15  0.32
2015 Hickey JL, Simpson EJ, Hou J, Luyt LG. An integrated imaging probe design: the synthesis of (99m)Tc/Re-containing macrocyclic peptide scaffolds. Chemistry (Weinheim An Der Bergstrasse, Germany). 21: 568-78. PMID 25388204 DOI: 10.1002/chem.201404774  0.64
2014 Bruckman MA, Jiang K, Simpson EJ, Randolph LN, Luyt LG, Yu X, Steinmetz NF. Dual-modal magnetic resonance and fluorescence imaging of atherosclerotic plaques in vivo using VCAM-1 targeted tobacco mosaic virus. Nano Letters. 14: 1551-8. PMID 24499194 DOI: 10.1021/nl404816m  0.56
2014 Douglas GA, McGirr R, Charlton CL, Kagan DB, Hoffman LM, Luyt LG, Dhanvantari S. Characterization of a far-red analog of ghrelin for imaging GHS-R in P19-derived cardiomyocytes. Peptides. 54: 81-8. PMID 24468548 DOI: 10.1016/j.peptides.2014.01.011  0.8
2014 Cho CF, Shukla S, Simpson EJ, Steinmetz NF, Luyt LG, Lewis JD. Molecular targeted viral nanoparticles as tools for imaging cancer. Methods in Molecular Biology (Clifton, N.J.). 1108: 211-30. PMID 24243252 DOI: 10.1007/978-1-62703-751-8_16  0.8
2012 Cho CF, Amadei GA, Breadner D, Luyt LG, Lewis JD. Discovery of novel integrin ligands from combinatorial libraries using a multiplex "beads on a bead" approach. Nano Letters. 12: 5957-65. PMID 23094984 DOI: 10.1021/nl3034043  0.8
2012 Hickey JL, Luyt LG. Synthesis of rhenium-centric reverse turn mimics. Chemistry (Weinheim An Der Bergstrasse, Germany). 18: 12999-3007. PMID 22945687 DOI: 10.1002/chem.201201766  0.64
2012 Simpson EJ, Hickey JL, Breadner D, Luyt LG. Investigation of isomer formation upon coordination of bifunctional histidine analogues with 99mTc/Re(CO)3. Dalton Transactions (Cambridge, England : 2003). 41: 2950-8. PMID 22266949 DOI: 10.1039/c2dt11962e  0.64
2012 Veiseh M, Breadner D, Ma J, Akentieva N, Savani RC, Harrison R, Mikilus D, Collis L, Gustafson S, Lee TY, Koropatnick J, Luyt LG, Bissell MJ, Turley EA. Imaging of homeostatic, neoplastic, and injured tissues by HA-based probes. Biomacromolecules. 13: 12-22. PMID 22066590 DOI: 10.1021/bm201143c  0.8
2012 Lu C, McFarland MS, Nesbitt RL, Williams AK, Chan S, Gomez-Lemus J, Autran-Gomez AM, Al-Zahrani A, Chin JL, Izawa JI, Luyt LG, Lewis JD. Ghrelin receptor as a novel imaging target for prostatic neoplasms. The Prostate. 72: 825-33. PMID 21919027 DOI: 10.1002/pros.21484  0.8
2011 McGirr R, McFarland MS, McTavish J, Luyt LG, Dhanvantari S. Design and characterization of a fluorescent ghrelin analog for imaging the growth hormone secretagogue receptor 1a Regulatory Peptides. 172: 69-76. PMID 21893106 DOI: 10.1016/j.regpep.2011.08.011  0.8
2011 Steinmetz NF, Ablack AL, Hickey JL, Ablack J, Manocha B, Mymryk JS, Luyt LG, Lewis JD. Intravital imaging of human prostate cancer using viral nanoparticles targeted to gastrin-releasing Peptide receptors. Small (Weinheim An Der Bergstrasse, Germany). 7: 1664-72. PMID 21520408 DOI: 10.1002/smll.201000435  0.64
2010 Behnam Azad B, Rota VA, Breadner D, Dhanvantari S, Luyt LG. Design, synthesis and in vitro characterization of Glucagon-Like Peptide-1 derivatives for pancreatic beta cell imaging by SPECT. Bioorganic & Medicinal Chemistry. 18: 1265-72. PMID 20056547 DOI: 10.1016/j.bmc.2009.12.032  0.52
2010 Amadei GA, Cho CF, Lewis JD, Luyt LG. A fast, reproducible and low-cost method for sequence deconvolution of 'on-bead' peptides via 'on-target' maldi-TOF/TOF mass spectrometry. Journal of Mass Spectrometry : Jms. 45: 241-51. PMID 20041400 DOI: 10.1002/jms.1708  0.8
2009 Martin AL, Hickey JL, Ablack AL, Lewis JD, Luyt LG, Gillies ER. Synthesis of bombesin-functionalized iron oxide nanoparticles and their specific uptake in prostate cancer cells. Journal of Nanoparticle Research : An Interdisciplinary Forum For Nanoscale Science and Technology. 12: 1599-1608. PMID 22328862 DOI: 10.1007/s11051-009-9681-3  0.8
2009 Hamilton SR, Veiseh M, Tölg C, Tirona R, Richardson J, Brown R, Gonzalez M, Vanzieleghem M, Anderson P, Asculai S, Winnik F, Savani R, Freeman D, Luyt L, Koropatnick J, et al. Pharmacokinetics and pharmacodynamics of hyaluronan infused into healthy human volunteers Open Drug Metabolism Journal. 3: 43-55. DOI: 10.2174/1874073100903010043  0.8
2005 Bigott HM, Parent E, Luyt LG, Katzenellenbogen JA, Welch MJ. Design and synthesis of functionalized cyclopentadienyl tricarbonylmetal complexes for technetium-94m PET imaging of estrogen receptors. Bioconjugate Chemistry. 16: 255-64. PMID 15769078 DOI: 10.1021/bc049770g  0.8
2003 Luyt LG, Bigott HM, Welch MJ, Katzenellenbogen JA. 7alpha- and 17alpha-substituted estrogens containing tridentate tricarbonyl rhenium/technetium complexes: synthesis of estrogen receptor imaging agents and evaluation using microPET with technetium-94m. Bioorganic & Medicinal Chemistry. 11: 4977-89. PMID 14604660 DOI: 10.1016/j.bmc.2003.09.004  0.8
2002 Luyt LG, Katzenellenbogen JA. A trithiolate tripodal bifunctional ligand for the radiolabeling of peptides with gallium(III) Bioconjugate Chemistry. 13: 1140-1145. PMID 12236797 DOI: 10.1021/bc025552g  0.8
2000 Hunter DH, Luyt LG. Single isomer technetium-99m tamoxifen conjugates. Bioconjugate Chemistry. 11: 175-81. PMID 10725094 DOI: 10.1021/BC990110Z  0.52
1994 Dinescu L, Mezo A, Luyt LG, Lemieux RP. A convenient synthesis of 6,6′-dialkoxythioindigo dyes suitable for doping into a liquid crystal host Tetrahedron Letters. 35: 7549-7552. DOI: 10.1016/S0040-4039(00)78340-7  0.8
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