David Segal, Ph.D. - Publications

Affiliations: 
UC Davis Genome Center UC Davis Genome Center 

52 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Fink KD, Deng P, Gutierrez J, Anderson JS, Torrest A, Komarla A, Kalomoiris S, Cary W, Anderson JD, Gruenloh W, Duffy A, Tempkin T, Wheelock V, Segal DJ, Nolta JA. Allele-specific reduction of the mutant huntingtin allele using transcription activator-like effectors in human Huntington's disease fibroblasts. Cell Transplantation. PMID 26850319 DOI: 10.3727/096368916X690863  0.8
2016 Tak YG, Hung Y, Yao L, Grimmer MR, Do A, Bhakta MS, O'Geen H, Segal DJ, Farnham PJ. Effects on the transcriptome upon deletion of a distal element cannot be predicted by the size of the H3K27Ac peak in human cells. Nucleic Acids Research. PMID 26743005 DOI: 10.1093/nar/gkv1530  0.8
2016 Bailus BJ, Pyles B, McAlister MM, O'Geen H, Lockwood SH, Adams AN, Nguyen JT, Yu A, Berman RF, Segal DJ. Protein Delivery of an Artificial Transcription Factor Restores Widespread Ube3a Expression in an Angelman Syndrome Mouse Brain. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 26727042 DOI: 10.1038/mt.2015.236  0.8
2015 O'Geen H, Yu AS, Segal DJ. How specific is CRISPR/Cas9 really? Current Opinion in Chemical Biology. 29: 72-78. PMID 26517564 DOI: 10.1016/j.cbpa.2015.10.001  0.8
2015 Frank AK, Tran DC, Qu RW, Stohr BA, Segal DJ, Xu L. The Shelterin TIN2 Subunit Mediates Recruitment of Telomerase to Telomeres. Plos Genetics. 11: e1005410. PMID 26230315 DOI: 10.1371/journal.pgen.1005410  0.8
2015 O'Geen H, Henry IM, Bhakta MS, Meckler JF, Segal DJ. A genome-wide analysis of Cas9 binding specificity using ChIP-seq and targeted sequence capture. Nucleic Acids Research. 43: 3389-404. PMID 25712100 DOI: 10.1093/nar/gkv137  0.8
2014 Rader C, Segal DJ, Shabat D. Carlos F. Barbas III (1964-2014): Visionary at the interface of chemistry and biology. Acs Chemical Biology. 9: 1645-6. PMID 25123302 DOI: 10.1021/cb5005993  1
2014 Vandevenne M, O'Connell MR, Helder S, Shepherd NE, Matthews JM, Kwan AH, Segal DJ, Mackay JP. Engineering specificity changes on a RanBP2 zinc finger that binds single-stranded RNA. Angewandte Chemie (International Ed. in English). 53: 7848-52. PMID 25044781 DOI: 10.1002/anie.201402980  0.8
2014 Barrilleaux BL, Burow D, Lockwood SH, Yu A, Segal DJ, Knoepfler PS. Miz-1 activates gene expression via a novel consensus DNA binding motif. Plos One. 9: e101151. PMID 24983942 DOI: 10.1371/journal.pone.0101151  0.8
2014 Lockwood SH, Guan A, Yu AS, Zhang C, Zykovich A, Korf I, Rannala B, Segal DJ. The functional significance of common polymorphisms in zinc finger transcription factors. G3 (Bethesda, Md.). 4: 1647-55. PMID 24970883 DOI: 10.1534/g3.114.012195  0.4
2014 Bailus BJ, Segal DJ. The prospect of molecular therapy for Angelman syndrome and other monogenic neurologic disorders. Bmc Neuroscience. 15: 76. PMID 24946931 DOI: 10.1186/1471-2202-15-76  0.8
2013 Mackay JP, Segal DJ, Crossley M. Is there a telltale RH fingerprint in zinc fingers that recognizes methylated CpG dinucleotides? Trends in Biochemical Sciences. 38: 421-2. PMID 23992945 DOI: 10.1016/j.tibs.2013.06.005  0.8
2013 Owens JB, Mauro D, Stoytchev I, Bhakta MS, Kim MS, Segal DJ, Moisyadi S. Transcription activator like effector (TALE)-directed piggyBac transposition in human cells. Nucleic Acids Research. 41: 9197-207. PMID 23921635 DOI: 10.1093/nar/gkt677  0.8
2013 Segal DJ, Meckler JF. Genome engineering at the dawn of the golden age. Annual Review of Genomics and Human Genetics. 14: 135-58. PMID 23701416 DOI: 10.1146/annurev-genom-091212-153435  0.8
2013 Vandevenne M, Jacques DA, Artuz C, Nguyen CD, Kwan AH, Segal DJ, Matthews JM, Crossley M, Guss JM, Mackay JP. New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217. The Journal of Biological Chemistry. 288: 10616-27. PMID 23436653 DOI: 10.1074/jbc.M112.441451  0.8
2013 Meckler JF, Bhakta MS, Kim MS, Ovadia R, Habrian CH, Zykovich A, Yu A, Lockwood SH, Morbitzer R, Elsäesser J, Lahaye T, Segal DJ, Baldwin EP. Quantitative analysis of TALE-DNA interactions suggests polarity effects. Nucleic Acids Research. 41: 4118-28. PMID 23408851 DOI: 10.1093/nar/gkt085  0.8
2013 Segal DJ. Bacteria herald a new era of gene editing. Elife. 2: e00563. PMID 23386979 DOI: 10.7554/eLife.00563  0.8
2013 Bhakta MS, Henry IM, Ousterout DG, Das KT, Lockwood SH, Meckler JF, Wallen MC, Zykovich A, Yu Y, Leo H, Xu L, Gersbach CA, Segal DJ. Highly active zinc-finger nucleases by extended modular assembly. Genome Research. 23: 530-8. PMID 23222846 DOI: 10.1101/gr.143693.112  0.8
2012 Segal DJ. Beyond the genome and into the clinic. Genome Medicine. 4: 78. PMID 23114014 DOI: 10.1186/gm379  0.8
2012 Meier JL, Yu AS, Korf I, Segal DJ, Dervan PB. Guiding the design of synthetic DNA-binding molecules with massively parallel sequencing. Journal of the American Chemical Society. 134: 17814-22. PMID 23013524 DOI: 10.1021/ja308888c  0.8
2012 O'Connell MR, Vandevenne M, Nguyen CD, Matthews JM, Gamsjaeger R, Segal DJ, Mackay JP. Modular assembly of RanBP2-type zinc finger domains to target single-stranded RNA. Angewandte Chemie (International Ed. in English). 51: 5371-5. PMID 22517726 DOI: 10.1002/anie.201200866  0.8
2012 Owens JB, Urschitz J, Stoytchev I, Dang NC, Stoytcheva Z, Belcaid M, Maragathavally KJ, Coates CJ, Segal DJ, Moisyadi S. Chimeric piggyBac transposases for genomic targeting in human cells. Nucleic Acids Research. 40: 6978-91. PMID 22492708 DOI: 10.1093/nar/gks309  0.8
2011 Shimizu Y, Şöllü C, Meckler JF, Adriaenssens A, Zykovich A, Cathomen T, Segal DJ. Adding fingers to an engineered zinc finger nuclease can reduce activity. Biochemistry. 50: 5033-41. PMID 21528840 DOI: 10.1021/bi200393g  0.8
2011 Segal DJ. Zinc-finger nucleases transition to the CoDA. Nature Methods. 8: 53-5. PMID 21191373 DOI: 10.1038/nmeth0111-53  0.8
2011 Kim MS, Stybayeva G, Lee JY, Revzin A, Segal DJ. A zinc finger protein array for the visual detection of specific DNA sequences for diagnostic applications. Nucleic Acids Research. 39: e29. PMID 21134909 DOI: 10.1093/nar/gkq1214  0.8
2010 Furman JL, Badran AH, Ajulo O, Porter JR, Stains CI, Segal DJ, Ghosh I. Toward a general approach for RNA-templated hierarchical assembly of split-proteins. Journal of the American Chemical Society. 132: 11692-701. PMID 20681585 DOI: 10.1021/ja104395b  0.8
2010 Porter JR, Lockwood SH, Segal DJ, Ghosh I. Seeing genetic and epigenetic information without DNA denaturation using sequence-enabled reassembly (SEER). Methods in Molecular Biology (Clifton, N.J.). 649: 365-82. PMID 20680847 DOI: 10.1007/978-1-60761-753-2_23  0.8
2009 Zykovich A, Korf I, Segal DJ. Bind-n-Seq: high-throughput analysis of in vitro protein-DNA interactions using massively parallel sequencing. Nucleic Acids Research. 37: e151. PMID 19843614 DOI: 10.1093/nar/gkp802  0.8
2009 Furman JL, Badran AH, Shen S, Stains CI, Hannallah J, Segal DJ, Ghosh I. Systematic evaluation of split-fluorescent proteins for the direct detection of native and methylated DNA. Bioorganic & Medicinal Chemistry Letters. 19: 3748-51. PMID 19457665 DOI: 10.1016/j.bmcl.2009.04.141  0.8
2008 Camenisch TD, Brilliant MH, Segal DJ. Critical parameters for genome editing using zinc finger nucleases. Mini Reviews in Medicinal Chemistry. 8: 669-76. PMID 18537722 DOI: 10.2174/138955708784567458  0.8
2007 Porter JR, Stains CI, Segal DJ, Ghosh I. Split beta-lactamase sensor for the sequence-specific detection of DNA methylation. Analytical Chemistry. 79: 6702-8. PMID 17685552 DOI: 10.1021/ac071163+  0.8
2007 Hartsock WJ, Cohen JD, Segal DJ. Uranyl acetate as a direct inhibitor of DNA-binding proteins. Chemical Research in Toxicology. 20: 784-9. PMID 17432879 DOI: 10.1021/tx600347k  0.8
2007 Shinohara ET, Kaminski JM, Segal DJ, Pelczar P, Kolhe R, Ryan T, Coates CJ, Fraser MJ, Handler AM, Yanagimachi R, Moisyadi S. Active integration: new strategies for transgenesis. Transgenic Research. 16: 333-9. PMID 17340207 DOI: 10.1007/s11248-007-9077-z  0.8
2006 Carroll D, Morton JJ, Beumer KJ, Segal DJ. Design, construction and in vitro testing of zinc finger nucleases. Nature Protocols. 1: 1329-41. PMID 17406419 DOI: 10.1038/nprot.2006.231  0.8
2006 Ghosh I, Stains CI, Ooi AT, Segal DJ. Direct detection of double-stranded DNA: Molecular methods and applications for DNA diagnostics. Molecular Biosystems. 2: 551-60. PMID 17216036 DOI: 10.1039/b611169f  0.8
2006 Segal DJ, Crotty JW, Bhakta MS, Barbas CF, Horton NC. Structure of Aart, a designed six-finger zinc finger peptide, bound to DNA. Journal of Molecular Biology. 363: 405-21. PMID 16963084 DOI: 10.1016/j.jmb.2006.08.016  0.8
2006 Stains CI, Furman JL, Segal DJ, Ghosh I. Site-specific detection of DNA methylation utilizing mCpG-SEER. Journal of the American Chemical Society. 128: 9761-5. PMID 16866532 DOI: 10.1021/ja060681j  0.8
2006 Ooi AT, Stains CI, Ghosh I, Segal DJ. Sequence-enabled reassembly of beta-lactamase (SEER-LAC): a sensitive method for the detection of double-stranded DNA. Biochemistry. 45: 3620-5. PMID 16533044 DOI: 10.1021/bi0517032  0.8
2006 Eberhardy SR, Goncalves J, Coelho S, Segal DJ, Berkhout B, Barbas CF. Inhibition of human immunodeficiency virus type 1 replication with artificial transcription factors targeting the highly conserved primer-binding site. Journal of Virology. 80: 2873-83. PMID 16501096 DOI: 10.1128/JVI.80.6.2873-2883.2006  0.8
2005 Crotty JW, Etzkorn C, Barbas CF, Segal DJ, Horton NC. Crystallization and preliminary X-ray crystallographic analysis of Aart, a designed six-finger zinc-finger peptide, bound to DNA. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 61: 573-6. PMID 16511099 DOI: 10.1107/S1744309105014363  0.8
2005 Dreier B, Fuller RP, Segal DJ, Lund CV, Blancafort P, Huber A, Koksch B, Barbas CF. Development of zinc finger domains for recognition of the 5'-CNN-3' family DNA sequences and their use in the construction of artificial transcription factors. The Journal of Biological Chemistry. 280: 35588-97. PMID 16107335 DOI: 10.1074/jbc.M506654200  0.8
2005 Stains CI, Porter JR, Ooi AT, Segal DJ, Ghosh I. DNA sequence-enabled reassembly of the green fluorescent protein. Journal of the American Chemical Society. 127: 10782-3. PMID 16076155 DOI: 10.1021/ja051969w  0.8
2005 Alwin S, Gere MB, Guhl E, Effertz K, Barbas CF, Segal DJ, Weitzman MD, Cathomen T. Custom zinc-finger nucleases for use in human cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. 12: 610-7. PMID 16039907 DOI: 10.1016/j.ymthe.2005.06.094  0.8
2005 Coates CJ, Kaminski JM, Summers JB, Segal DJ, Miller AD, Kolb AF. Site-directed genome modification: derivatives of DNA-modifying enzymes as targeting tools. Trends in Biotechnology. 23: 407-19. PMID 15993503 DOI: 10.1016/j.tibtech.2005.06.009  0.8
2005 Kolb AF, Coates CJ, Kaminski JM, Summers JB, Miller AD, Segal DJ. Site-directed genome modification: nucleic acid and protein modules for targeted integration and gene correction. Trends in Biotechnology. 23: 399-406. PMID 15982766 DOI: 10.1016/j.tibtech.2005.06.005  0.8
2004 Blancafort P, Segal DJ, Barbas CF. Designing transcription factor architectures for drug discovery. Molecular Pharmacology. 66: 1361-71. PMID 15340042 DOI: 10.1124/mol.104.002758  0.8
2004 Segal DJ, Gonçalves J, Eberhardy S, Swan CH, Torbett BE, Li X, Barbas CF. Attenuation of HIV-1 Replication in Primary Human Cells with a Designed Zinc Finger Transcription Factor Journal of Biological Chemistry. 279: 14509-14519. PMID 14734553 DOI: 10.1074/jbc.M400349200  0.8
2004 Tan W, Zhu K, Segal DJ, Barbas CF, Chow SA. Fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc finger protein E2C direct integration of viral DNA into specific sites. Journal of Virology. 78: 1301-13. PMID 14722285 DOI: 10.1128/JVI.78.3.1301-1313.2004  0.8
2003 Segal DJ, Beerli RR, Blancafort P, Dreier B, Effertz K, Huber A, Koksch B, Lund CV, Magnenat L, Valente D, Barbas CF. Evaluation of a modular strategy for the construction of novel polydactyl zinc finger DNA-binding proteins. Biochemistry. 42: 2137-48. PMID 12590603 DOI: 10.1021/bi026806o  0.8
2002 Segal DJ. The use of zinc finger peptides to study the role of specific factor binding sites in the chromatin environment Methods. 26: 76-83. PMID 12054906 DOI: 10.1016/S1046-2023(02)00009-9  0.8
2002 Segal DJ, Barbas CF. Custom DNA-binding proteins come of age: polydactyl zinc-finger proteins. Current Opinion in Biotechnology. 12: 632-7. PMID 11849947 DOI: 10.1016/S0958-1669(01)00272-5  0.4
2000 Barbas CF, Rader C, Segal DJ, List B, Turner JM. From catalytic asymmetric synthesis to the transcriptional regulation of genes: in vivo and in vitro evolution of proteins. Advances in Protein Chemistry. 55: 317-66. PMID 11050938 DOI: 10.1016/S0065-3233(01)55008-1  0.8
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