Year |
Citation |
Score |
2022 |
Eskandari R, Kim N, Mamakhanyan A, Saoi M, Zhang G, Berisaj M, Granlund KL, Poot AJ, Cross J, Thompson CB, Keshari KR. Hyperpolarized [5-C,4,4-H,5-N]-L-glutamine provides a means of annotating in vivo metabolic utilization of glutamine. Proceedings of the National Academy of Sciences of the United States of America. 119: e2120595119. PMID 35512101 DOI: 10.1073/pnas.2120595119 |
0.401 |
|
2021 |
Ge EJ, Bush AI, Casini A, Cobine PA, Cross JR, DeNicola GM, Dou QP, Franz KJ, Gohil VM, Gupta S, Kaler SG, Lutsenko S, Mittal V, Petris MJ, Polishchuk R, et al. Connecting copper and cancer: from transition metal signalling to metalloplasia. Nature Reviews. Cancer. PMID 34764459 DOI: 10.1038/s41568-021-00417-2 |
0.558 |
|
2021 |
Zhu J, Schwörer S, Berisa M, Kyung YJ, Ryu KW, Yi J, Jiang X, Cross JR, Thompson CB. Mitochondrial NADP(H) generation is essential for proline biosynthesis. Science (New York, N.Y.). PMID 33888598 DOI: 10.1126/science.abd5491 |
0.427 |
|
2020 |
Pavlova NN, King B, Josselsohn RH, Violante S, Macera VL, Vardhana SA, Cross JR, Thompson CB. Translation in amino acid-poor environments is limited by tRNA charging. Elife. 9. PMID 33289483 DOI: 10.7554/eLife.62307 |
0.411 |
|
2020 |
Vardhana SA, Hwee MA, Berisa M, Wells DK, Yost KE, King B, Smith M, Herrera PS, Chang HY, Satpathy AT, van den Brink MRM, Cross JR, Thompson CB. Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen. Nature Immunology. PMID 32661364 DOI: 10.1038/S41590-020-0725-2 |
0.477 |
|
2020 |
Campbell C, McKenney PT, Konstantinovsky D, Isaeva OI, Schizas M, Verter J, Mai C, Jin WB, Guo CJ, Violante S, Ramos RJ, Cross JR, Kadaveru K, Hambor J, Rudensky AY. Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells. Nature. 581: 475-479. PMID 32461639 DOI: 10.1038/S41586-020-2193-0 |
0.362 |
|
2020 |
Cai Y, Rattray NJW, Zhang Q, Mironova V, Santos-Neto A, Hsu KS, Rattray Z, Cross JR, Zhang Y, Paty PB, Khan SA, Johnson CH. Sex Differences in Colon Cancer Metabolism Reveal A Novel Subphenotype. Scientific Reports. 10: 4905. PMID 32184446 DOI: 10.1038/S41598-020-61851-0 |
0.316 |
|
2020 |
Schwörer S, Berisa M, Violante S, Qin W, Zhu J, Hendrickson RC, Cross JR, Thompson CB. Proline biosynthesis is a vent for TGFβ-induced mitochondrial redox stress. The Embo Journal. e103334. PMID 32134147 DOI: 10.15252/Embj.2019103334 |
0.486 |
|
2020 |
Chen CC, Li B, Millman SE, Chen C, Li X, Morris JP, Mayle A, Ho YJ, Loizou E, Liu H, Qin W, Shah H, Violante S, Cross JR, Lowe SW, et al. Vitamin B6 Addiction in Acute Myeloid Leukemia. Cancer Cell. 37: 71-84.e7. PMID 31935373 DOI: 10.1016/J.Ccell.2019.12.002 |
0.368 |
|
2019 |
Zhu J, Berisa M, Schwörer S, Qin W, Cross JR, Thompson CB. Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation. Cell Metabolism. PMID 31607565 DOI: 10.1016/J.Cmet.2019.09.009 |
0.542 |
|
2019 |
Li M, Chiang YL, Lyssiotis CA, Teater MR, Hong JY, Shen H, Wang L, Hu J, Jing H, Chen Z, Jain N, Duy C, Mistry SJ, Cerchietti L, Cross JR, et al. Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis. Cancer Cell. 35: 916-931.e9. PMID 31185214 DOI: 10.1016/J.Ccell.2019.05.002 |
0.386 |
|
2019 |
Singh K, Lin J, Zhong Y, Burčul A, Mohan P, Jiang M, Sun L, Yong-Gonzalez V, Viale A, Cross JR, Hendrickson RC, Rätsch G, Ouyang Z, Wendel HG. c-MYC regulates mRNA translation efficiency and start-site selection in lymphoma. The Journal of Experimental Medicine. PMID 31142587 DOI: 10.1084/Jem.20181726 |
0.325 |
|
2019 |
Violante S, Berisa M, Thomas TH, Cross JR. Stable Isotope Tracers for Metabolic Pathway Analysis. Methods in Molecular Biology (Clifton, N.J.). 1978: 269-283. PMID 31119669 DOI: 10.1007/978-1-4939-9236-2_17 |
0.308 |
|
2018 |
Intlekofer AM, Shih AH, Wang B, Nazir A, Rustenburg AS, Albanese SK, Patel M, Famulare C, Correa FM, Takemoto N, Durani V, Liu H, Taylor J, Farnoud N, Papaemmanuil E, ... Cross JR, et al. Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations. Nature. PMID 29950729 DOI: 10.1038/S41586-018-0251-7 |
0.471 |
|
2017 |
Vitiello GA, Medina BD, Zeng S, Bowler TG, Zhang JQ, Loo JK, Param NJ, Liu M, Moral JA, Zhao JN, Rossi F, Antonescu CR, Balachandran VP, Cross JR, DeMatteo RP. Mitochondrial inhibition augments the efficacy of imatinib by resetting the metabolic phenotype of gastrointestinal stromal tumor. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 29246941 DOI: 10.1158/1078-0432.Ccr-17-2697 |
0.371 |
|
2017 |
Turcan S, Makarov V, Taranda J, Wang Y, Fabius AWM, Wu W, Zheng Y, El-Amine N, Haddock S, Nanjangud G, LeKaye HC, Brennan C, Cross J, Huse JT, Kelleher NL, et al. Mutant-IDH1-dependent chromatin state reprogramming, reversibility, and persistence. Nature Genetics. PMID 29180699 DOI: 10.1038/S41588-017-0001-Z |
0.486 |
|
2017 |
Salamanca-Cardona L, Shah H, Poot AJ, Correa FM, Di Gialleonardo V, Lui H, Miloushev VZ, Granlund KL, Tee SS, Cross JR, Thompson CB, Keshari KR. In Vivo Imaging of Glutamine Metabolism to the Oncometabolite 2-Hydroxyglutarate in IDH1/2 Mutant Tumors. Cell Metabolism. PMID 29056515 DOI: 10.1016/J.Cmet.2017.10.001 |
0.516 |
|
2017 |
Cohen LJ, Esterhazy D, Kim SH, Lemetre C, Aguilar RR, Gordon EA, Pickard AJ, Cross JR, Emiliano AB, Han SM, Chu J, Vila-Farres X, Kaplitt J, Rogoz A, Calle PY, et al. Commensal bacteria make GPCR ligands that mimic human signalling molecules. Nature. PMID 28854168 DOI: 10.1038/Nature23874 |
0.31 |
|
2017 |
Intlekofer AM, Wang B, Liu H, Shah H, Carmona-Fontaine C, Rustenburg AS, Salah S, Gunner MR, Chodera JD, Cross JR, Thompson CB. L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH. Nature Chemical Biology. PMID 28263965 DOI: 10.1038/Nchembio.2307 |
0.5 |
|
2017 |
Li M, Chiang Y, Lyssiotis C, Teater M, Shen H, Wang L, Hong JY, Jin H, Duy C, Mistry S, Cerchietti L, Cross J, Cantley L, Lin H, Melnick A. SIRT3 Is a Novel Metabolic Driver of and Therapeutic Target for Chemotherapy Resistant Dlbcls Blood. 130: 643-643. DOI: 10.1182/Blood.V130.Suppl_1.643.643 |
0.435 |
|
2016 |
Guryanova OA, Shank K, Spitzer B, Luciani L, Koche RP, Garrett-Bakelman FE, Ganzel C, Durham BH, Mohanty A, Hoermann G, Rivera SA, Chramiec AG, Pronier E, Bastian L, Keller MD, ... ... Cross JR, et al. DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling. Nature Medicine. PMID 27841873 DOI: 10.1038/Nm.4210 |
0.33 |
|
2016 |
Monticelli LA, Buck MD, Flamar AL, Saenz SA, Tait Wojno ED, Yudanin NA, Osborne LC, Hepworth MR, Tran SV, Rodewald HR, Shah H, Cross JR, Diamond JM, Cantu E, Christie JD, et al. Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation. Nature Immunology. PMID 27043409 DOI: 10.1038/Ni.3421 |
0.37 |
|
2015 |
Intlekofer AM, Dematteo RG, Venneti S, Finley LW, Lu C, Judkins AR, Rustenburg AS, Grinaway PB, Chodera JD, Cross JR, Thompson CB. Hypoxia Induces Production of L-2-Hydroxyglutarate. Cell Metabolism. PMID 26212717 DOI: 10.1016/J.Cmet.2015.06.023 |
0.483 |
|
2015 |
Su X, Yu Y, Zhong Y, Giannopoulou EG, Hu X, Liu H, Cross JR, Rätsch G, Rice CM, Ivashkiv LB. Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation. Nature Immunology. 16: 838-49. PMID 26147685 DOI: 10.1038/Ni.3205 |
0.308 |
|
2015 |
Venneti S, Dunphy MP, Zhang H, Pitter KL, Zanzonico P, Campos C, Carlin SD, La Rocca G, Lyashchenko S, Ploessl K, Rohle D, Omuro AM, Cross JR, Brennan CW, Weber WA, et al. Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo. Science Translational Medicine. 7: 274ra17. PMID 25673762 DOI: 10.1126/Scitranslmed.Aaa1009 |
0.45 |
|
2015 |
Pedicord VA, Cross JR, Montalvo-Ortiz W, Miller ML, Allison JP. Friends not foes: CTLA-4 blockade and mTOR inhibition cooperate during CD8+ T cell priming to promote memory formation and metabolic readiness. Journal of Immunology (Baltimore, Md. : 1950). 194: 2089-98. PMID 25624453 DOI: 10.4049/Jimmunol.1402390 |
0.3 |
|
2015 |
Carey BW, Finley LW, Cross JR, Allis CD, Thompson CB. Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells. Nature. 518: 413-6. PMID 25487152 DOI: 10.1038/Nature13981 |
0.527 |
|
2015 |
Thompson CB, Intlekofer AM, Dematteo RG, Venneti S, Finley LWS, Lu C, Rustenburg AS, Grinaway PB, Chodera JD, Cross JR, Judkins AR. Abstract SY43-01: Stereochemistry matters: L-2HG as a tumor response to hypoxia Cancer Research. 75. DOI: 10.1158/1538-7445.Am2015-Sy43-01 |
0.491 |
|
2015 |
Fuente MIdl, Young R, Rubel J, Tisnado J, Briggs S, Holodny AI, Deasy J, DeAngelis LM, Cross J, Mellinghoff IK, Thakur S. Abstract 1498: Feasibility of 2-hydroxyglutarate 1H-MR spectroscopy for routine clinical glioma imaging Cancer Research. 75: 1498-1498. DOI: 10.1158/1538-7445.Am2015-1498 |
0.307 |
|
2014 |
Zhang J, Fan J, Venneti S, Cross JR, Takagi T, Bhinder B, Djaballah H, Kanai M, Cheng EH, Judkins AR, Pawel B, Baggs J, Cherry S, Rabinowitz JD, Thompson CB. Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion. Molecular Cell. 56: 205-18. PMID 25242145 DOI: 10.1016/J.Molcel.2014.08.018 |
0.609 |
|
2014 |
Ye J, Fan J, Venneti S, Wan YW, Pawel BR, Zhang J, Finley LW, Lu C, Lindsten T, Cross JR, Qing G, Liu Z, Simon MC, Rabinowitz JD, Thompson CB. Serine catabolism regulates mitochondrial redox control during hypoxia. Cancer Discovery. 4: 1406-17. PMID 25186948 DOI: 10.1158/2159-8290.Cd-14-0250 |
0.613 |
|
2014 |
Shi Y, Wang J, Chandarlapaty S, Cross J, Thompson C, Rosen N, Jiang X. PTEN is a protein tyrosine phosphatase for IRS1 Nature Structural and Molecular Biology. 21: 522-527. PMID 24814346 DOI: 10.1038/Nsmb.2828 |
0.448 |
|
2014 |
Intlekofer AM, Dematteo RG, Finley LW, Cross JR, Thompson CB. Leukemia-Associated Oncometabolite 2-Hydroxyglutarate Regulates Epigenetic Modifications in Response to Oxygen Availability in Cells without IDH1/2 Mutations Blood. 124: 872-872. DOI: 10.1182/Blood.V124.21.872.872 |
0.504 |
|
2014 |
Venneti S, Dunphy M, Zhang H, Pitter K, Campos C, Carlin S, Lyashchenko S, Ploessl C, Rohle D, Omuro A, Cross J, Brennan C, Weber W, Holland E, Mellinghoff I, et al. TM-15 * GLUTAMINE BASED PET IMAGING FACILITATES ENHANCED METABOLIC DETECTION OF GLIOMAS IN VIVO Neuro-Oncology. 16: v216-v216. DOI: 10.1093/Neuonc/Nou278.14 |
0.461 |
|
2013 |
Lee CH, Cross JR, Li Z, Chen Y, Neri B, Reuter VE, Motzer RJ, Russo P, Hsieh J. Global metabolic profiling of clear cell renal cell carcinoma. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 31: 379. PMID 28136900 DOI: 10.1200/Jco.2013.31.6_Suppl.379 |
0.304 |
|
2013 |
Piovan E, Yu J, Tosello V, Herranz D, Ambesi-Impiombato A, Da Silva AC, Sanchez-Martin M, Perez-Garcia A, Rigo I, Castillo M, Indraccolo S, Cross JR, de Stanchina E, Paietta E, Racevskis J, et al. Direct reversal of glucocorticoid resistance by AKT inhibition in acute lymphoblastic leukemia. Cancer Cell. 24: 766-76. PMID 24291004 DOI: 10.1016/J.Ccr.2013.10.022 |
0.316 |
|
2013 |
Arpaia N, Campbell C, Fan X, Dikiy S, van der Veeken J, deRoos P, Liu H, Cross JR, Pfeffer K, Coffer PJ, Rudensky AY. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature. 504: 451-5. PMID 24226773 DOI: 10.1038/Nature12726 |
0.35 |
|
2013 |
Lu C, Venneti S, Akalin A, Fang F, Ward PS, Dematteo RG, Intlekofer AM, Chen C, Ye J, Hameed M, Nafa K, Agaram NP, Cross JR, Khanin R, Mason CE, et al. Induction of sarcomas by mutant IDH2. Genes & Development. 27: 1986-98. PMID 24065766 DOI: 10.1101/Gad.226753.113 |
0.581 |
|
2013 |
Chen C, Liu Y, Lu C, Cross JR, Morris JP, Shroff AS, Ward PS, Bradner JE, Thompson C, Lowe SW. Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition. Genes & Development. 27: 1974-85. PMID 24065765 DOI: 10.1101/Gad.226613.113 |
0.514 |
|
2013 |
Kamphorst JJ, Cross JR, Fan J, de Stanchina E, Mathew R, White EP, Thompson CB, Rabinowitz JD. Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids. Proceedings of the National Academy of Sciences of the United States of America. 110: 8882-7. PMID 23671091 DOI: 10.1073/Pnas.1307237110 |
0.587 |
|
2013 |
Ward PS, Lu C, Cross JR, Abdel-Wahab O, Levine RL, Schwartz GK, Thompson CB. The potential for isocitrate dehydrogenase mutations to produce 2-hydroxyglutarate depends on allele specificity and subcellular compartmentalization. The Journal of Biological Chemistry. 288: 3804-15. PMID 23264629 DOI: 10.1074/Jbc.M112.435495 |
0.498 |
|
2012 |
Ward PS, Cross JR, Lu C, Weigert O, Abel-Wahab O, Levine RL, Weinstock DM, Sharp KA, Thompson CB. Identification of additional IDH mutations associated with oncometabolite R(-)-2-hydroxyglutarate production. Oncogene. 31: 2491-8. PMID 21996744 DOI: 10.1038/Onc.2011.416 |
0.48 |
|
2012 |
Kamphorst JJ, Cross JR, Fan J, Lu W, White E, Thompson CB, Rabinowitz JD. Ras-driven cancer cells can scavenge exogenous lipids to support their proliferation Bmc Proceedings. 6. DOI: 10.1186/1753-6561-6-S3-P25 |
0.497 |
|
2011 |
Wise DR, Ward PS, Shay JE, Cross JR, Gruber JJ, Sachdeva UM, Platt JM, DeMatteo RG, Simon MC, Thompson CB. Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability. Proceedings of the National Academy of Sciences of the United States of America. 108: 19611-6. PMID 22106302 DOI: 10.1073/Pnas.1117773108 |
0.721 |
|
2010 |
Vento MT, Zazzu V, Loffreda A, Cross JR, Downward J, Stoppelli MP, Iaccarino I. Praf2 is a novel Bcl-xL/Bcl-2 interacting protein with the ability to modulate survival of cancer cells. Plos One. 5: e15636. PMID 21203533 DOI: 10.1371/Journal.Pone.0015636 |
0.482 |
|
2010 |
Krawczyk CM, Holowka T, Sun J, Blagih J, Amiel E, DeBerardinis RJ, Cross JR, Jung E, Thompson CB, Jones RG, Pearce EJ. Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation. Blood. 115: 4742-9. PMID 20351312 DOI: 10.1182/Blood-2009-10-249540 |
0.482 |
|
2010 |
Ward PS, Patel J, Wise DR, Abdel-Wahab O, Bennett BD, Coller HA, Cross JR, Fantin VR, Hedvat CV, Perl AE, Rabinowitz JD, Carroll M, Su SM, Sharp KA, Levine RL, et al. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell. 17: 225-34. PMID 20171147 DOI: 10.1016/J.Ccr.2010.01.020 |
0.478 |
|
2009 |
Wellen KE, Hatzivassiliou G, Sachdeva UM, Bui TV, Cross JR, Thompson CB. ATP-citrate lyase links cellular metabolism to histone acetylation. Science (New York, N.Y.). 324: 1076-80. PMID 19461003 DOI: 10.1126/Science.1164097 |
0.481 |
|
2008 |
Cross JR, Postigo A, Blight K, Downward J. Viral pro-survival proteins block separate stages in Bax activation but changes in mitochondrial ultrastructure still occur. Cell Death and Differentiation. 15: 997-1008. PMID 18274554 DOI: 10.1038/Cdd.2008.14 |
0.465 |
|
2006 |
Postigo A, Cross JR, Downward J, Way M. Interaction of F1L with the BH3 domain of Bak is responsible for inhibiting vaccinia-induced apoptosis Cell Death and Differentiation. 13: 1651-1662. PMID 16439990 DOI: 10.1038/Sj.Cdd.4401853 |
0.443 |
|
2004 |
Govek EE, Newey SE, Akerman CJ, Cross JR, Van der Veken L, Van Aelst L. The X-linked mental retardation protein oligophrenin-1 is required for dendritic spine morphogenesis. Nature Neuroscience. 7: 364-72. PMID 15034583 DOI: 10.1038/Nn1210 |
0.589 |
|
2000 |
Boettner B, Govek EE, Cross J, Van Aelst L. The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin. Proceedings of the National Academy of Sciences of the United States of America. 97: 9064-9. PMID 10922060 DOI: 10.1073/Pnas.97.16.9064 |
0.575 |
|
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