Robert Charles Hider, PhD - Publications

1967 Department of Biochemistry King's College London, London, UK 
 1968- Department of Physiology and Biochemistry University of Reading, Earley, England, United Kingdom 
 1980-1993 Department of Chemistry Essex University 
 1993- Institute of Pharmaceutical Science, Faculty of Life Science & Medicine King's College London, London, UK 
Iron Chelator, Chelator, Medicinal Chemistry, Chemical Biology, Amino Acid, Biosynthesis

138 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Chen W, Yuan X, Li Z, Lu Z, Kong S, Jiang H, Du H, Pan X, Nandi M, Kong X, Brown K, Liu Z, Zhang G, Hider RC, Yu Y. CN128, a new orally active hydroxypyridinone iron chelator. Journal of Medicinal Chemistry. PMID 32208614 DOI: 10.1021/acs.jmedchem.0c00137  1
2020 Poeschl A, Mountford DM, Hider RC, Cilibrizzi A. Synthetic Approaches for Piperidone-Based Templates as Scaffolds to Access Chirally Enriched Donepezil Analogues. Acs Omega. 5: 2378-2396. PMID 32064399 DOI: 10.1021/acsomega.9b03808  0.96
2019 Chuljerm H, Chen YL, Srichairatanakool S, Hider RC, Cilibrizzi A. Synthesis and iron coordination properties of schizokinen and its imide derivative. Dalton Transactions (Cambridge, England : 2003). PMID 31742278 DOI: 10.1039/c9dt02731a  1
2019 Yan H, Xiao XQ, Hider RC, Ma Y. A Simple Metal-Free Cyclization for the Synthesis of 4-Methylene-3-Substituted Quinazolinone and Quinazolinthione Derivatives: Experiment and Theory. Frontiers in Chemistry. 7: 584. PMID 31475141 DOI: 10.3389/fchem.2019.00584  1
2019 Shao LL, Zhou JM, Zhu Q, Wang XL, Hider RC, Zhou T. Enzymatic characteristics of polyphenoloxidase from shrimp () and its inhibition by a novel hydroxypyridinone derivative. Food Science and Biotechnology. 28: 1047-1055. PMID 31275704 DOI: 10.1007/s10068-018-00544-x  1
2019 Paradee N, Howes MR, Utama-Ang N, Chaikitwattna A, Hider RC, Srichairatanakool S. A chemically characterized ethanolic extract of Thai Perilla frutescens (L.) Britton fruits (nutlets) reduces oxidative stress and lipid peroxidation in human hepatoma (HuH7) cells. Phytotherapy Research : Ptr. PMID 31141248 DOI: 10.1002/ptr.6396  0.64
2019 Imberti C, Chen YL, Foley CA, Ma MT, Paterson BM, Wang Y, Young JD, Hider RC, Blower PJ. Tuning the properties of tris(hydroxypyridinone) ligands: efficient Ga chelators for PET imaging. Dalton Transactions (Cambridge, England : 2003). PMID 30860215 DOI: 10.1039/c8dt04454f  1
2019 Zhou T, Kong XL, Hider RC. Synthesis and iron chelating properties of hydroxypyridinone and hydroxypyranone hexadentate ligands. Dalton Transactions (Cambridge, England : 2003). PMID 30793715 DOI: 10.1039/c8dt05014g  1
2019 Reelfs O, Abbate V, Cilibrizzi A, Pook MA, Hider RC, Pourzand C. The role of mitochondrial labile iron in Friedreich's ataxia skin fibroblasts sensitivity to ultraviolet A. Metallomics : Integrated Biometal Science. PMID 30778428 DOI: 10.1039/c8mt00257f  0.96
2018 Zhou T, Battah S, Mazzacuva F, Hider RC, Dobbin PS, MacRobert AJ. Design of Bifunctional Dendritic 5-Aminolevulinic Acid and Hydroxypyridinone Conjugates for Photodynamic Therapy. Bioconjugate Chemistry. PMID 30249090 DOI: 10.1021/acs.bioconjchem.8b00574  1
2018 Mei KC, Ghazaryan A, Teoh EZ, Summers HD, Li Y, Ballesteros B, Piasecka J, Walters A, Hider RC, Mailänder V, Al-Jamal KT. Protein-Corona-by-Design in 2D: A Reliable Platform to Decode Bio-Nano Interactions for the Next-Generation Quality-by-Design Nanomedicines. Advanced Materials (Deerfield Beach, Fla.). e1802732. PMID 30144166 DOI: 10.1002/adma.201802732  0.76
2018 Cilibrizzi A, Abbate V, Chen YL, Ma Y, Zhou T, Hider RC. Hydroxypyridinone Journey into Metal Chelation. Chemical Reviews. PMID 30033720 DOI: 10.1021/acs.chemrev.8b00254  1
2018 Zhou T, Chen K, Kong LM, Liu MS, Ma YM, Xie YY, Hider RC. Synthesis, iron binding and antimicrobial properties of hexadentate 3-hydroxypyridinones-terminated dendrimers. Bioorganic & Medicinal Chemistry Letters. PMID 29886020 DOI: 10.1016/j.bmcl.2018.05.058  1
2018 Benaouda F, Jones SA, Chana J, Dal Corno BM, Barlow DJ, Hider RC, Page CP, Forbes B. Ion-pairing with spermine targets theophylline to the lungs via the polyamine transport system. Molecular Pharmaceutics. PMID 29307184 DOI: 10.1021/acs.molpharmaceut.7b00715  1
2018 Shao LL, Wang XL, Chen K, Dong XW, Kong LM, Zhao DY, Hider RC, Zhou T. Novel hydroxypyridinone derivatives containing an oxime ether moiety: Synthesis, inhibition on mushroom tyrosinase and application in anti-browning of fresh-cut apples. Food Chemistry. 242: 174-181. PMID 29037675 DOI: 10.1016/j.foodchem.2017.09.054  1
2017 Chen YL, Kong X, Xie Y, Hider RC. The interaction of pyridoxal isonicotinoyl hydrazone (PIH) and salicylaldehyde isonicotinoyl hydrazone (SIH) with iron. Journal of Inorganic Biochemistry. 180: 194-203. PMID 29329026 DOI: 10.1016/j.jinorgbio.2017.12.007  1
2017 Dubey RD, Klippstein R, Wang JT, Hodgins N, Mei KC, Sosabowski J, Hider RC, Abbate V, Gupta PN, Al-Jamal KT. Novel Hyaluronic Acid Conjugates for Dual Nuclear Imaging and Therapy in CD44-Expressing Tumors in Mice In Vivo. Nanotheranostics. 1: 59-79. PMID 29071179 DOI: 10.7150/ntno.17896  0.96
2017 Shao LL, Xu J, Shi MJ, Wang XL, Li YT, Kong LM, Hider RC, Zhou T. Preparation, antioxidant and antimicrobial evaluation of hydroxamated degraded polysaccharides from Enteromorpha prolifera. Food Chemistry. 237: 481-487. PMID 28764023 DOI: 10.1016/j.foodchem.2017.05.119  1
2017 Young JD, Abbate V, Imberti C, Meszaros LK, Ma MT, Terry SY, Hider RC, Mullen GE, Blower PJ. (68)Ga-THP-PSMA: a PET imaging agent for prostate cancer offering rapid, room temperature, one-step kit-based radiolabeling. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 28408532 DOI: 10.2967/jnumed.117.191882  0.96
2017 Battah S, Hider RC, MacRobert AJ, Dobbin PS, Zhou T. Hydroxypyridinone and 5-aminolaevulinic acid conjugates for photodynamic therapy. Journal of Medicinal Chemistry. PMID 28363026 DOI: 10.1021/acs.jmedchem.7b00346  1
2017 Cusnir R, Imberti C, Hider RC, Blower PJ, Ma MT. Hydroxypyridinone Chelators: From Iron Scavenging to Radiopharmaceuticals for PET Imaging with Gallium-68. International Journal of Molecular Sciences. 18. PMID 28075350 DOI: 10.3390/ijms18010116  0.32
2016 Srivastava S, Blower PJ, Aubdool AA, Hider RC, Mann GE, Siow RC. Cardioprotective effects of Cu((II))ATSM in human vascular smooth muscle cells and cardiomyocytes mediated by Nrf2 and DJ-1. Scientific Reports. 6: 7. PMID 28442712 DOI: 10.1038/s41598-016-0012-5  0.32
2016 Chen BJ, Shi MJ, Cui S, Hao SX, Hider RC, Zhou T. Improved antioxidant and anti-tyrosinase activity of polysaccharide from Sargassum fusiforme by degradation. International Journal of Biological Macromolecules. PMID 27471085 DOI: 10.1016/j.ijbiomac.2016.07.082  1
2016 Zhao DY, Zhang MX, Dong XW, Hu YZ, Dai XY, Wei X, Hider RC, Zhang JC, Zhou T. Design and synthesis of novel hydroxypyridinone derivatives as potential tyrosinase inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 27185329 DOI: 10.1016/j.bmcl.2016.05.006  1
2016 Reelfs O, Abbate V, Hider RC, Pourzand C. A Powerful Mitochondria-Targeted Iron Chelator Affords High Photoprotection against Solar Ultraviolet A Radiation. The Journal of Investigative Dermatology. 136: 1692-700. PMID 27109868 DOI: 10.1016/j.jid.2016.03.041  0.96
2016 Kulprachakarn K, Chen YL, Kong X, Arno MC, Hider RC, Srichairatanakool S, Bansal SS. Copper(II) binding properties of hepcidin. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. PMID 26883683 DOI: 10.1007/s00775-016-1342-2  1
2015 Li J, Lu Z, Kong X, Ma Y, Zhang X, Bansal SS, Abbate V, Hider RC. Design and synthesis of novel pegylated iron chelators with decreased metabolic rate. Future Medicinal Chemistry. 7: 2439-49. PMID 26670054 DOI: 10.4155/fmc.15.154  0.96
2015 Saghaie L, Liu D, Hider RC. Synthesis of polymers containing 3-hydroxypyridin-4-one bidentate ligands for treatment of iron overload. Research in Pharmaceutical Sciences. 10: 364-377. PMID 26600863  0.96
2015 Abbate V, Reelfs O, Kong X, Pourzand C, Hider RC. Dual selective iron chelating probes with a potential to monitor mitochondrial labile iron pools. Chemical Communications (Cambridge, England). PMID 26567874 DOI: 10.1039/c5cc06170a  1
2015 de Swart L, Hendriks JC, van der Vorm LN, Cabantchik ZI, Evans PJ, Hod EA, Brittenham GM, Furman Y, Wojczyk B, Janssen MC, Porter JB, Mattijssen VE, Biemond BJ, MacKenzie MA, Origa R, ... ... Hider RC, et al. Second International Round Robin for the Quantification of Serum Non-Transferrin-Bound Iron and Labile Plasma Iron in Patients with Iron-Overload Disorders. Haematologica. PMID 26385212 DOI: 10.3324/haematol.2015.133983  1
2015 Mei KC, Rubio N, Costa PM, Kafa H, Abbate V, Festy F, Bansal SS, Hider RC, Al-Jamal KT. Synthesis of double-clickable functionalised graphene oxide for biological applications. Chemical Communications (Cambridge, England). 51: 14981-4. PMID 26295072 DOI: 10.1039/c5cc05412e  0.96
2015 Bonaccorsi-Riani E, Danger R, Lozano JJ, Martinez-Picola M, Kodela E, Mas-Malavila R, Bruguera M, Collins HL, Hider RC, Martinez-Llordella M, Sanchez-Fueyo A. Iron Deficiency Impairs Intra-Hepatic Lymphocyte Mediated Immune Response. Plos One. 10: e0136106. PMID 26287688 DOI: 10.1371/journal.pone.0136106  0.4
2015 Rubio N, Mei KC, Klippstein R, Costa PM, Hodgins N, Wang JT, Festy F, Abbate V, Hider RC, Chan KL, Al-Jamal KT. Solvent-Free Click-Mechanochemistry for the Preparation of Cancer Cell Targeting Graphene Oxide. Acs Applied Materials & Interfaces. 7: 18920-3. PMID 26278410 DOI: 10.1021/acsami.5b06250  0.96
2015 Mei KC, Guo Y, Bai J, Costa PM, Kafa H, Protti A, Hider RC, Al-Jamal KT. Organic Solvent-Free, One-Step Engineering of Graphene-Based Magnetic-Responsive Hybrids Using Design of Experiment-Driven Mechanochemistry. Acs Applied Materials & Interfaces. PMID 26101940 DOI: 10.1021/acsami.5b03577  0.76
2015 Abbate V, Reelfs O, Hider RC, Pourzand C. Design of novel fluorescent mitochondria-targeted peptides with iron-selective sensing activity. The Biochemical Journal. 469: 357-66. PMID 26008950 DOI: 10.1042/BJ20150149  0.96
2015 Ma Y, Zhou T, Hider RC. pFe(3+) determination of multidentate ligands by a fluorescence assay. The Analyst. 140: 3603-6. PMID 25857340 DOI: 10.1039/c5an00123d  1
2015 Zhou YJ, Liu MS, Osamah AR, Kong XL, Alsam S, Battah S, Xie YY, Hider RC, Zhou T. Hexadentate 3-hydroxypyridin-4-ones with high iron(III) affinity: design, synthesis and inhibition on methicillin resistant Staphylococcus aureus and Pseudomonas strains. European Journal of Medicinal Chemistry. 94: 8-21. PMID 25747496 DOI: 10.1016/j.ejmech.2015.02.050  1
2015 Hider RC, Kong X, Abbate V, Harland R, Conlon K, Luker T. Deferitazole, a new orally active iron chelator. Dalton Transactions (Cambridge, England : 2003). 44: 5197-204. PMID 25687725 DOI: 10.1039/c5dt00063g  1
2015 Pangjit K, Banjerdpongchai R, Phisalaphong C, Fucharoen S, Xie YY, Lu ZD, Hider RC, Srichairatanakool S. Characterisation of a novel oral iron chelator: 1-(N-Acetyl-6-Aminohexyl)-3-Hydroxy-2-Methylpyridin-4-one. The Journal of Pharmacy and Pharmacology. 67: 703-13. PMID 25627251 DOI: 10.1111/jphp.12373  0.88
2015 Zhou T, Hider RC, Kong X. Mode of iron(III) chelation by hexadentate hydroxypyridinones. Chemical Communications (Cambridge, England). 51: 5614-7. PMID 25611052 DOI: 10.1039/c4cc10339d  1
2015 Zhu CF, Battah S, Kong X, Reeder BJ, Hider RC, Zhou T. Design, synthesis and biological evaluation of 5-aminolaevulinic acid/3-hydroxypyridinone conjugates as potential photodynamic therapeutical agents. Bioorganic & Medicinal Chemistry Letters. 25: 558-61. PMID 25556100 DOI: 10.1016/j.bmcl.2014.12.018  1
2015 Ma MT, Meszaros LK, Paterson BM, Berry DJ, Cooper MS, Ma Y, Hider RC, Blower PJ. Tripodal tris(hydroxypyridinone) ligands for immunoconjugate PET imaging with (89)Zr(4+): comparison with desferrioxamine-B. Dalton Transactions (Cambridge, England : 2003). 44: 4884-900. PMID 25351250 DOI: 10.1039/c4dt02978j  1
2014 Ma Y, Kong X, Chen YL, Hider RC. Synthesis and characterizations of pyridazine-based iron chelators. Dalton Transactions (Cambridge, England : 2003). 43: 17120-8. PMID 25311299 DOI: 10.1039/c4dt02687j  1
2014 Kulprachakarn K, Chansiw N, Pangjit K, Phisalaphong C, Fucharoen S, Hider RC, Santitherakul S, Srichairatanakool S. Iron-chelating and anti-lipid peroxidation properties of 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) in long-term iron loading β-thalassemic mice. Asian Pacific Journal of Tropical Biomedicine. 4: 663-8. PMID 25183338 DOI: 10.12980/APJTB.4.2014APJTB-2014-0155  0.64
2014 Ma Y, Podinovskaia M, Evans PJ, Emma G, Schaible UE, Porter J, Hider RC. A novel method for non-transferrin-bound iron quantification by chelatable fluorescent beads based on flow cytometry. The Biochemical Journal. 463: 351-62. PMID 25093426 DOI: 10.1042/BJ20140795  1
2014 Zhang MX, Zhu CF, Zhou YJ, Kong XL, Hider RC, Zhou T. Design, synthesis, and antimicrobial evaluation of hexadentate hydroxypyridinones with high iron(III) affinity. Chemical Biology & Drug Design. 84: 659-68. PMID 24890019 DOI: 10.1111/cbdd.12358  1
2014 Zhou YJ, Zhang MX, Hider RC, Zhou T. In vitro antimicrobial activity of hydroxypyridinone hexadentate-based dendrimeric chelators alone and in combination with norfloxacin. Fems Microbiology Letters. 355: 124-30. PMID 24813898 DOI: 10.1111/1574-6968.12465  1
2014 Schmid NB, Giehl RF, Döll S, Mock HP, Strehmel N, Scheel D, Kong X, Hider RC, von Wirén N. Feruloyl-CoA 6'-Hydroxylase1-dependent coumarins mediate iron acquisition from alkaline substrates in Arabidopsis. Plant Physiology. 164: 160-72. PMID 24246380 DOI: 10.1104/pp.113.228544  1
2013 Hider RC, Kong X. Iron: effect of overload and deficiency. Metal Ions in Life Sciences. 13: 229-94. PMID 24470094 DOI: 10.1007/978-94-007-7500-8_8  1
2013 Arezes J, Costa M, Vieira I, Dias V, Kong XL, Fernandes R, Vos M, Carlsson A, Rikers Y, Porto G, Rangel M, Hider RC, Pinto JP. Non-transferrin-bound iron (NTBI) uptake by T lymphocytes: evidence for the selective acquisition of oligomeric ferric citrate species. Plos One. 8: e79870. PMID 24278199 DOI: 10.1371/journal.pone.0079870  1
2013 Zhou T, Hider RC, Jenner P, Campbell B, Hobbs CJ, Rose S, Jairaj M, Tayarani-Binazir KA, Syme A. Design, synthesis and biological evaluation of peptide derivatives of L-dopa as anti-parkinsonian agents. Bioorganic & Medicinal Chemistry Letters. 23: 5279-82. PMID 23973169 DOI: 10.1016/j.bmcl.2013.08.007  1
2013 Dürrenberger F, Abbate V, Ma Y, Arno MC, Jaiash D, Parmar A, Marshall V, Latunde-Dada GO, Zimmermann T, Senn D, Altermatt P, Manolova V, Hider RC, Bansal SS. Functional characterization of fluorescent hepcidin. Bioconjugate Chemistry. 24: 1527-32. PMID 23888876 DOI: 10.1021/bc400121x  1
2013 Li DF, Hu PP, Liu MS, Kong XL, Zhang JC, Hider RC, Zhou T. Design and synthesis of hydroxypyridinone-L-phenylalanine conjugates as potential tyrosinase inhibitors. Journal of Agricultural and Food Chemistry. 61: 6597-603. PMID 23802151 DOI: 10.1021/jf401585f  1
2013 Zhu CF, Qiu DH, Kong XL, Hider RC, Zhou T. Synthesis and in-vitro antimicrobial evaluation of a high-affinity iron chelator in combination with chloramphenicol. The Journal of Pharmacy and Pharmacology. 65: 512-20. PMID 23488779 DOI: 10.1111/jphp.12013  1
2013 Gehrke SS, Pinto EG, Steverding D, Pleban K, Tempone AG, Hider RC, Wagner GK. Conjugation to 4-aminoquinoline improves the anti-trypanosomal activity of Deferiprone-type iron chelators Bioorganic and Medicinal Chemistry. 21: 805-813. PMID 23266185 DOI: 10.1016/j.bmc.2012.11.009  1
2013 Hider RC, Kong X. Iron speciation in the cytosol: an overview. Dalton Transactions (Cambridge, England : 2003). 42: 3220-9. PMID 23232973 DOI: 10.1039/c2dt32149a  1
2013 Ma Y, Xie Y, Hider RC. A novel fluorescence method for determination of pFe3+. The Analyst. 138: 96-9. PMID 23085963 DOI: 10.1039/c2an36186h  1
2012 Chen YL, Doltsinis NL, Hider RC, Barlow DJ. Prediction of Absolute Hydroxyl pKa Values for 3-Hydroxypyridin-4-ones. The Journal of Physical Chemistry Letters. 3: 2980-5. PMID 26292237 DOI: 10.1021/jz301061m  1
2012 Zhao B, Moody SC, Hider RC, Lei L, Kelly SL, Waterman MR, Lamb DC. Structural analysis of cytochrome P450 105N1 involved in the biosynthesis of the zincophore, coelibactin. International Journal of Molecular Sciences. 13: 8500-13. PMID 22942716 DOI: 10.3390/ijms13078500  1
2012 Chen YL, Barlow DJ, Kong XL, Ma YM, Hider RC. Prediction of 3-hydroxypyridin-4-one (HPO) log K1 values for Fe(III). Dalton Transactions (Cambridge, England : 2003). 41: 10784-91. PMID 22854534 DOI: 10.1039/c2dt31254a  1
2012 Chen YL, Barlow DJ, Kong XL, Ma YM, Hider RC. Prediction of 3-hydroxypyridin-4-one (HPO) hydroxyl pKa values. Dalton Transactions (Cambridge, England : 2003). 41: 6549-57. PMID 22395734 DOI: 10.1039/c2dt12396g  1
2012 Zhou T, Ma Y, Kong X, Hider RC. Design of iron chelators with therapeutic application. Dalton Transactions (Cambridge, England : 2003). 41: 6371-89. PMID 22391807 DOI: 10.1039/c2dt12159j  1
2012 Ma Y, Roy S, Kong X, Chen Y, Liu D, Hider RC. Design and synthesis of fluorinated iron chelators for metabolic study and brain uptake. Journal of Medicinal Chemistry. 55: 2185-95. PMID 22339047 DOI: 10.1021/jm201475u  1
2012 Evans RW, Kong X, Hider RC. Iron mobilization from transferrin by therapeutic iron chelating agents. Biochimica Et Biophysica Acta. 1820: 282-90. PMID 22155077 DOI: 10.1016/j.bbagen.2011.11.007  1
2012 Lomer MC, Cook WB, Jan-Mohamed HJ, Hutchinson C, Liu DY, Hider RC, Powell JJ. Iron requirements based upon iron absorption tests are poorly predicted by haematological indices in patients with inactive inflammatory bowel disease. The British Journal of Nutrition. 107: 1806-11. PMID 22152498 DOI: 10.1017/S0007114511004971  0.8
2011 Xu B, Kong XL, Zhou T, Qiu DH, Chen YL, Liu MS, Yang RH, Hider RC. Synthesis, iron(III)-binding affinity and in vitro evaluation of 3-hydroxypyridin-4-one hexadentate ligands as potential antimicrobial agents. Bioorganic & Medicinal Chemistry Letters. 21: 6376-80. PMID 21937227 DOI: 10.1016/j.bmcl.2011.08.097  1
2011 Hider RC, Kong XL. Glutathione: a key component of the cytoplasmic labile iron pool. Biometals : An International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine. 24: 1179-87. PMID 21769609 DOI: 10.1007/s10534-011-9476-8  1
2011 Rahmioglu N, Heaton J, Clement G, Gill R, Surdulescu G, Zlobecka K, Hodgkiss D, Ma Y, Hider RC, Smith NW, Ahmadi KR. Genetic epidemiology of induced CYP3A4 activity. Pharmacogenetics and Genomics. 21: 642-51. PMID 21750469 DOI: 10.1097/FPC.0b013e3283498ecf  1
2011 Zhou T, Winkelmann G, Dai ZY, Hider RC. Design of clinically useful macromolecular iron chelators. The Journal of Pharmacy and Pharmacology. 63: 893-903. PMID 21635254 DOI: 10.1111/j.2042-7158.2011.01291.x  1
2011 Berry DJ, Ma Y, Ballinger JR, Tavaré R, Koers A, Sunassee K, Zhou T, Nawaz S, Mullen GE, Hider RC, Blower PJ. Efficient bifunctional gallium-68 chelators for positron emission tomography: tris(hydroxypyridinone) ligands. Chemical Communications (Cambridge, England). 47: 7068-70. PMID 21623436 DOI: 10.1039/c1cc12123e  1
2011 Baek JH, Reiter CE, Manalo DJ, Buehler PW, Hider RC, Alayash AI. Induction of hypoxia inducible factor (HIF-1α) in rat kidneys by iron chelation with the hydroxypyridinone, CP94. Biochimica Et Biophysica Acta. 1809: 262-8. PMID 21558026 DOI: 10.1016/j.bbagrm.2011.04.010  0.52
2011 Hider RC, Roy S, Ma YM, Le Kong X, Preston J. The potential application of iron chelators for the treatment of neurodegenerative diseases. Metallomics : Integrated Biometal Science. 3: 239-49. PMID 21344071 DOI: 10.1039/c0mt00087f  1
2011 Staff K, Brown MB, Chilcott RP, Hider RC, Jones SA, Kong XL. Ga(III) complexes-The effect of metal coordination on potential systemic absorption after topical exposure Toxicology Letters. 202: 155-160. PMID 21315140 DOI: 10.1016/j.toxlet.2011.01.017  1
2011 Gaeta A, Molina-Holgado F, Kong XL, Salvage S, Fakih S, Francis PT, Williams RJ, Hider RC. Synthesis, physical-chemical characterisation and biological evaluation of novel 2-amido-3-hydroxypyridin-4(1H)-ones: Iron chelators with the potential for treating Alzheimer's disease. Bioorganic & Medicinal Chemistry. 19: 1285-97. PMID 21236688 DOI: 10.1016/j.bmc.2010.12.007  1
2011 Qiu DH, Huang ZL, Zhou T, Shen C, Hider RC. In vitro inhibition of bacterial growth by iron chelators. Fems Microbiology Letters. 314: 107-11. PMID 21114684 DOI: 10.1111/j.1574-6968.2010.02153.x  1
2010 Macdougall IC, Malyszko J, Hider RC, Bansal SS. Current status of the measurement of blood hepcidin levels in chronic kidney disease. Clinical Journal of the American Society of Nephrology : Cjasn. 5: 1681-9. PMID 20724518 DOI: 10.2215/CJN.05990809  1
2010 Roy S, Preston JE, Hider RC, Ma YM. Glucosylated deferiprone and its brain uptake: implications for developing glucosylated hydroxypyridinone analogues intended to cross the blood-brain barrier. Journal of Medicinal Chemistry. 53: 5886-9. PMID 20684616 DOI: 10.1021/jm100380k  1
2010 Zhou T, Hider RC, Jenner P, Campbell B, Hobbs CJ, Rose S, Jairaj M, Tayarani-Binazir KA, Syme A. Design, synthesis and biological evaluation of L-dopa amide derivatives as potential prodrugs for the treatment of Parkinson's disease. European Journal of Medicinal Chemistry. 45: 4035-42. PMID 20646792 DOI: 10.1016/j.ejmech.2010.05.062  1
2010 Lan Y, Langlet-Bertin B, Abbate V, Vermeer LS, Kong X, Sullivan KE, Leborgne C, Scherman D, Hider RC, Drake AF, Bansal SS, Kichler A, Mason AJ. Incorporation of 2,3-diaminopropionic acid into linear cationic amphipathic peptides produces pH-sensitive vectors. Chembiochem : a European Journal of Chemical Biology. 11: 1266-72. PMID 20480482 DOI: 10.1002/cbic.201000073  1
2010 Piyamongkol S, Ma YM, Kong XL, Liu ZD, Aytemir MD, van der Helm D, Hider RC. Amido-3-hydroxypyridin-4-ones as iron(III) ligands. Chemistry (Weinheim An Der Bergstrasse, Germany). 16: 6374-81. PMID 20397153 DOI: 10.1002/chem.200902455  1
2010 Bansal SS, Abbate V, Bomford A, Halket JM, Macdougall IC, Thein SL, Hider RC. Quantitation of hepcidin in serum using ultra-high-pressure liquid chromatography and a linear ion trap mass spectrometer. Rapid Communications in Mass Spectrometry : Rcm. 24: 1251-9. PMID 20391595 DOI: 10.1002/rcm.4512  1
2010 Hider RC, Kong X. Chemistry and biology of siderophores. Natural Product Reports. 27: 637-57. PMID 20376388 DOI: 10.1039/b906679a  1
2010 Nunes A, Podinovskaia M, Leite A, Gameiro P, Zhou T, Ma Y, Kong X, Schaible UE, Hider RC, Rangel M. Fluorescent 3-hydroxy-4-pyridinone hexadentate iron chelators: intracellular distribution and the relevance to antimycobacterial properties. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 15: 861-77. PMID 20364296 DOI: 10.1007/s00775-010-0650-1  1
2010 Fernandes SS, Nunes A, Gomes AR, de Castro B, Hider RC, Rangel M, Appelberg R, Gomes MS. Identification of a new hexadentate iron chelator capable of restricting the intramacrophagic growth of Mycobacterium avium. Microbes and Infection / Institut Pasteur. 12: 287-94. PMID 20097303 DOI: 10.1016/j.micinf.2010.01.003  0.64
2010 Kerkweg U, Pamp K, Fieker J, Petrat F, Hider RC, de Groot H. Release of redox-active iron by muscle crush trauma: no liberation into the circulation. Shock (Augusta, Ga.). 33: 513-8. PMID 19823114 DOI: 10.1097/SHK.0b013e3181c4f56e  0.6
2009 Kroot JJ, Kemna EH, Bansal SS, Busbridge M, Campostrini N, Girelli D, Hider RC, Koliaraki V, Mamalaki A, Olbina G, Tomosugi N, Tselepis C, Ward DG, Ganz T, Hendriks JC, et al. Results of the first international round robin for the quantification of urinary and plasma hepcidin assays: need for standardization. Haematologica. 94: 1748-52. PMID 19996119 DOI: 10.3324/haematol.2009.010322  1
2009 Ma YM, Hider RC. The selective quantification of iron by hexadentate fluorescent probes Bioorganic and Medicinal Chemistry. 17: 8093-8101. PMID 19853460 DOI: 10.1016/j.bmc.2009.09.052  1
2009 Silva AM, Kong X, Parkin MC, Cammack R, Hider RC. Iron(III) citrate speciation in aqueous solution. Dalton Transactions (Cambridge, England : 2003). 8616-25. PMID 19809738 DOI: 10.1039/b910970f  1
2009 Silva AM, Hider RC. Influence of non-enzymatic post-translation modifications on the ability of human serum albumin to bind iron. Implications for non-transferrin-bound iron speciation. Biochimica Et Biophysica Acta. 1794: 1449-58. PMID 19505594 DOI: 10.1016/j.bbapap.2009.06.003  0.56
2009 Bansal SS, Halket JM, Fusova J, Bomford A, Simpson RJ, Vasavda N, Thein SL, Hider RC. Quantification of hepcidin using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Rapid Communications in Mass Spectrometry : Rcm. 23: 1531-42. PMID 19399775 DOI: 10.1002/rcm.4033  1
2009 Silva AM, Kong X, Hider RC. Determination of the pKa value of the hydroxyl group in the alpha-hydroxycarboxylates citrate, malate and lactate by 13C NMR: implications for metal coordination in biological systems. Biometals : An International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine. 22: 771-8. PMID 19288211 DOI: 10.1007/s10534-009-9224-5  1
2009 Bansal SS, Halket JM, Bomford A, Simpson RJ, Vasavda N, Thein SL, Hider RC. Quantitation of hepcidin in human urine by liquid chromatography-mass spectrometry. Analytical Biochemistry. 384: 245-53. PMID 18951868 DOI: 10.1016/j.ab.2008.09.045  1
2009 Fakih S, Podinovskaia M, Kong X, Schaible UE, Collins HL, Hider RC. Monitoring intracellular labile iron pools: A novel fluorescent iron(III) sensor as a potential non-invasive diagnosis tool. Journal of Pharmaceutical Sciences. 98: 2212-26. PMID 18823046 DOI: 10.1002/jps.21583  1
2009 Laftah AH, Latunde-Dada GO, Fakih S, Hider RC, Simpson RJ, McKie AT. Haem and folate transport by proton-coupled folate transporter/haem carrier protein 1 (SLC46A1). The British Journal of Nutrition. 101: 1150-6. PMID 18782461 DOI: 10.1017/S0007114508066762  0.44
2008 Hider RC, Ma Y, Molina-Holgado F, Gaeta A, Roy S. Iron chelation as a potential therapy for neurodegenerative disease. Biochemical Society Transactions. 36: 1304-8. PMID 19021545 DOI: 10.1042/BST0361304  1
2008 Fakih S, Podinovskaia M, Kong X, Collins HL, Schaible UE, Hider RC. Targeting the lysosome: fluorescent iron(III) chelators to selectively monitor endosomal/lysosomal labile iron pools. Journal of Medicinal Chemistry. 51: 4539-52. PMID 18624421 DOI: 10.1021/jm8001247  1
2008 Zhou T, Kong XL, Liu ZD, Liu DY, Hider RC. Synthesis and iron(III)-chelating properties of novel 3-hydroxypyridin-4-one hexadentate ligand-containing copolymers. Biomacromolecules. 9: 1372-80. PMID 18373358 DOI: 10.1021/bm701122u  1
2008 Molina-Holgado F, Gaeta A, Francis PT, Williams RJ, Hider RC. Neuroprotective actions of deferiprone in cultured cortical neurones and SHSY-5Y cells. Journal of Neurochemistry. 105: 2466-76. PMID 18331585 DOI: 10.1111/j.1471-4159.2008.05332.x  0.6
2008 Kong X, Neubert H, Zhou T, Liu ZD, Hider RC. MALDI mass spectrometric determination of dendritic iron chelation stoichiometries and conditional affinity constants. Journal of Mass Spectrometry : Jms. 43: 617-22. PMID 18286664 DOI: 10.1002/jms.1357  1
2008 Hutchinson C, Conway RE, Bomford A, Hider RC, Powell JJ, Geissler CA. Post-prandial iron absorption in humans: comparison between HFE genotypes and iron deficiency anaemia. Clinical Nutrition (Edinburgh, Scotland). 27: 258-63. PMID 18276042 DOI: 10.1016/j.clnu.2007.12.007  0.36
2008 Reeder BJ, Cutruzzola F, Bigotti MG, Hider RC, Wilson MT. Tyrosine as a redox-active center in electron transfer to ferryl heme in globins. Free Radical Biology & Medicine. 44: 274-83. PMID 18215736 DOI: 10.1016/j.freeradbiomed.2007.06.030  0.6
2008 Reeder BJ, Hider RC, Wilson MT. Iron chelators can protect against oxidative stress through ferryl heme reduction Free Radical Biology and Medicine. 44: 264-273. PMID 18215735 DOI: 10.1016/j.freeradbiomed.2007.08.006  1
2008 Devanur LD, Evans RW, Evans PJ, Hider RC. Chelator-facilitated removal of iron from transferrin: relevance to combined chelation therapy. The Biochemical Journal. 409: 439-47. PMID 17919118 DOI: 10.1042/BJ20070823  0.96
2008 Evans RW, Rafique R, Zarea A, Rapisarda C, Cammack R, Evans PJ, Porter JB, Hider RC. Nature of non-transferrin-bound iron: studies on iron citrate complexes and thalassemic sera. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 13: 57-74. PMID 17906879 DOI: 10.1007/s00775-007-0297-8  0.96
2008 Dehkordi LS, Liu ZD, Hider RC. Basic 3-hydroxypyridin-4-ones: potential antimalarial agents. European Journal of Medicinal Chemistry. 43: 1035-47. PMID 17869385 DOI: 10.1016/j.ejmech.2007.07.011  1
2008 Devanur LD, Neubert H, Hider RC. The fenton activity of iron(III) in the presence of deferiprone. Journal of Pharmaceutical Sciences. 97: 1454-67. PMID 17724662 DOI: 10.1002/jps.21039  1
2007 Ma Y, Liu Z, Hider RC, Petrat F. Determination of the labile iron pool of human lymphocytes using the fluorescent probe, CP655. Analytical Chemistry Insights. 2: 61-7. PMID 19662178  1
2007 Kong X, Zhou T, Liu Z, Hider RC. pH indicator titration: a novel fast pKa determination method. Journal of Pharmaceutical Sciences. 96: 2777-83. PMID 17621680 DOI: 10.1002/jps.20959  1
2007 Lin Z, Liao Y, Venkatasamy R, Hider RC, Soumyanath A. Amides from Piper nigrum L. with dissimilar effects on melanocyte proliferation in-vitro. The Journal of Pharmacy and Pharmacology. 59: 529-36. PMID 17430636 DOI: 10.1211/jpp.59.4.0007  0.52
2007 Molina-Holgado F, Hider RC, Gaeta A, Williams R, Francis P. Metals ions and neurodegeneration. Biometals : An International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine. 20: 639-54. PMID 17294125 DOI: 10.1007/s10534-006-9033-z  0.6
2007 Diggle SP, Matthijs S, Wright VJ, Fletcher MP, Chhabra SR, Lamont IL, Kong X, Hider RC, Cornelis P, Cámara M, Williams P. The Pseudomonas aeruginosa 4-quinolone signal molecules HHQ and PQS play multifunctional roles in quorum sensing and iron entrapment. Chemistry & Biology. 14: 87-96. PMID 17254955 DOI: 10.1016/j.chembiol.2006.11.014  1
2006 Soumyanath A, Venkatasamy R, Joshi M, Faas L, Adejuyigbe B, Drake AF, Hider RC, Young AR. UV irradiation affects melanocyte stimulatory activity and protein binding of piperine. Photochemistry and Photobiology. 82: 1541-8. PMID 17387768  0.52
2006 Zhou T, Neubert H, Liu DY, Liu ZD, Ma YM, Kong XL, Luo W, Mark S, Hider RC. Iron binding dendrimers: a novel approach for the treatment of haemochromatosis. Journal of Medicinal Chemistry. 49: 4171-82. PMID 16821777 DOI: 10.1021/jm0600949  1
2006 Ren Y, Houghton P, Hider RC. Relevant activities of extracts and constituents of animals used in traditional Chinese medicine for central nervous system effects associated with Alzheimer's disease. The Journal of Pharmacy and Pharmacology. 58: 989-96. PMID 16805960 DOI: 10.1211/jpp.58.7.0015  0.36
2006 Kong X, Zhou T, Neubert H, Liu Z, Hider RC. 3-Hydroxy-2-(5-hydroxypentyl)-4H-chromen-4-one: a bidentate or tridentate iron(III) ligand? Journal of Medicinal Chemistry. 49: 3028-31. PMID 16686545 DOI: 10.1021/jm050905t  1
2006 Lee DH, Liu DY, Jacobs DR, Shin HR, Song K, Lee IK, Kim B, Hider RC. Common presence of non-transferrin-bound iron among patients with type 2 diabetes. Diabetes Care. 29: 1090-5. PMID 16644642 DOI: 10.2337/diacare.2951090  0.8
2006 Barral K, Balzarini J, Neyts J, De Clercq E, Hider RC, Camplo M. Synthesis and antiviral evaluation of cyclic and acyclic 2-methyl-3-hydroxy-4-pyridinone nucleoside derivatives. Journal of Medicinal Chemistry. 49: 43-50. PMID 16392791 DOI: 10.1021/jm0504306  0.64
2006 Ma Y, de Groot H, Liu Z, Hider RC, Petrat F. Chelation and determination of labile iron in primary hepatocytes by pyridinone fluorescent probes. The Biochemical Journal. 395: 49-55. PMID 16336208 DOI: 10.1042/BJ20051496  1
2005 Hider RC, Zhou T. The design of orally active iron chelators. Annals of the New York Academy of Sciences. 1054: 141-54. PMID 16339660 DOI: 10.1196/annals.1345.017  1
2005 Gaeta A, Hider RC. The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy. British Journal of Pharmacology. 146: 1041-59. PMID 16205720 DOI: 10.1038/sj.bjp.0706416  0.6
2005 Zhou T, Liu ZD, Neubert H, Kong XL, Ma YM, Hider RC. High affinity iron(III) scavenging by a novel hexadentate 3-hydroxypyridin-4-one-based dendrimer: synthesis and characterization. Bioorganic & Medicinal Chemistry Letters. 15: 5007-11. PMID 16153843 DOI: 10.1016/j.bmcl.2005.08.008  1
2005 Shayeghi M, Latunde-Dada GO, Oakhill JS, Laftah AH, Takeuchi K, Halliday N, Khan Y, Warley A, McCann FE, Hider RC, Frazer DM, Anderson GJ, Vulpe CD, Simpson RJ, McKie AT. Identification of an intestinal heme transporter. Cell. 122: 789-801. PMID 16143108 DOI: 10.1016/j.cell.2005.06.025  1
2005 Berndt UE, Zhou T, Hider RC, Liu ZD, Neubert H. Structural characterization of chelator-terminated dendrimers and their synthetic intermediates by mass spectrometry. Journal of Mass Spectrometry : Jms. 40: 1203-14. PMID 16127663 DOI: 10.1002/jms.899  1
2005 Ma Y, Luo W, Camplo M, Liu Z, Hider RC. Novel iron-specific fluorescent probes. Bioorganic & Medicinal Chemistry Letters. 15: 3450-2. PMID 15950474 DOI: 10.1016/j.bmcl.2005.05.010  1
2005 Jacobs EM, Hendriks JC, van Tits BL, Evans PJ, Breuer W, Liu DY, Jansen EH, Jauhiainen K, Sturm B, Porter JB, Scheiber-Mojdehkar B, von Bonsdorff L, Cabantchik ZI, Hider RC, Swinkels DW. Results of an international round robin for the quantification of serum non-transferrin-bound iron: Need for defining standardization and a clinically relevant isoform. Analytical Biochemistry. 341: 241-50. PMID 15907869 DOI: 10.1016/j.ab.2005.03.008  0.8
2004 Ma Y, Luo W, Quinn PJ, Liu Z, Hider RC. Design, synthesis, physicochemical properties, and evaluation of novel iron chelators with fluorescent sensors. Journal of Medicinal Chemistry. 47: 6349-62. PMID 15566304 DOI: 10.1021/jm049751s  1
2004 Lewis EA, Khodr HH, Hider RC, Lindsay Smith JR, Walton PH. A manganese superoxide dismutase mimic based on cis,cis-1,3,5-triaminocyclohexane. Dalton Transactions (Cambridge, England : 2003). 187-8. PMID 15356711 DOI: 10.1039/b314955b  1
2004 Ren Y, Houghton PJ, Hider RC, Howes MJ. Novel diterpenoid acetylcholinesterase inhibitors from Salvia miltiorhiza. Planta Medica. 70: 201-4. PMID 15114495 DOI: 10.1055/s-2004-815535  0.36
2004 Luo W, Ma YM, Quinn PJ, Hider RC, Liu ZD. Design, synthesis and properties of novel iron(III)-specific fluorescent probes. The Journal of Pharmacy and Pharmacology. 56: 529-36. PMID 15099448 DOI: 10.1211/0022357023196  1
2004 Venkatasamy R, Faas L, Young AR, Raman A, Hider RC. Effects of piperine analogues on stimulation of melanocyte proliferation and melanocyte differentiation. Bioorganic & Medicinal Chemistry. 12: 1905-20. PMID 15051059 DOI: 10.1016/j.bmc.2004.01.036  0.52
2003 Barral K, Hider RC, Balzarini J, Neyts J, De Clercq E, Camplo M. Synthesis and antiviral evaluation of 3-hydroxy-2-methylpyridin-4-one dideoxynucleoside derivatives. Bioorganic & Medicinal Chemistry Letters. 13: 4371-4. PMID 14643328  0.64
2003 Hider RC, Liu ZD. Emerging understanding of the advantage of small molecules such as hydroxypyridinones in the treatment of iron overload. Current Medicinal Chemistry. 10: 1051-64. PMID 12678676  1
2002 Liu ZD, Liu DY, Hider RC. Iron chelator chemistry. Advances in Experimental Medicine and Biology. 509: 141-66. PMID 12572993  1
2002 Liu DY, Liu ZD, Hider RC. Oral iron chelators--development and application. Best Practice & Research. Clinical Haematology. 15: 369-84. PMID 12401312  1
2002 Loréal O, Turlin B, Pigeon C, Moisan A, Ropert M, Morice P, Gandon Y, Jouanolle AM, Vérin M, Hider RC, Yoshida K, Brissot P. Aceruloplasminemia: New clinical, pathophysiological and therapeutic insights Journal of Hepatology. 36: 851-856. PMID 12044538 DOI: 10.1016/S0168-8278(02)00042-9  1
2002 Moridani MY, Tilbrook GS, Khodr HH, Hider RC. Synthesis and physicochemical assessment of novel 2-substituted 3-hydroxypyridin-4-ones, novel iron chelators Journal of Pharmacy and Pharmacology. 54: 349-364. PMID 11902801 DOI: 10.1211/0022357021778592  1
2002 Liu ZD, Kayyali R, Hider RC, Porter JB, Theobald AE. Design, synthesis, and evaluation of novel 2-substituted 3-hydroxypyridin-4-ones: structure-activity investigation of metalloenzyme inhibition by iron chelators. Journal of Medicinal Chemistry. 45: 631-9. PMID 11806714  1
2002 Liu ZD, Hider RC. Design of clinically useful iron(III)-selective chelators. Medicinal Research Reviews. 22: 26-64. PMID 11746175 DOI: 10.1002/med.1027  1
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